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Conserved domains on  [gi|505384768|ref|WP_015571870|]
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MULTISPECIES: AraC family transcriptional regulator [Enterobacter]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12071870)

AraC family transcriptional regulator contains a helix-turn-helix DNA-binding motif and controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  9409145|8451183

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 28-171 1.58e-46

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


:

Pssm-ID: 461994  Cd Length: 152  Bit Score: 153.43  E-value: 1.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768   28 LPDIRLLYGTQPGTRTPVMYQPGIVFLFSGHKIGYINERVFRYDTNEYLLLTVPLPFECE-TFATEEVPLAGIRVNVDIL 106
Cdd:pfam06719   2 IPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEvTEASPEEPYLGLALDLDPA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505384768  107 QLQELLMEIGEDELfrPSMAASGINSATLSEEILCAIERLLDVMERPLDARILGKQIIREILYHV 171
Cdd:pfam06719  82 LLAELLLEAPPPGP--PPRAGRGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRL 144
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
207-288 1.96e-27

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 101.86  E-value: 1.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768   207 NLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTP 286
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 505384768   287 GE 288
Cdd:smart00342  81 SE 82
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 28-171 1.58e-46

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 153.43  E-value: 1.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768   28 LPDIRLLYGTQPGTRTPVMYQPGIVFLFSGHKIGYINERVFRYDTNEYLLLTVPLPFECE-TFATEEVPLAGIRVNVDIL 106
Cdd:pfam06719   2 IPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEvTEASPEEPYLGLALDLDPA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505384768  107 QLQELLMEIGEDELfrPSMAASGINSATLSEEILCAIERLLDVMERPLDARILGKQIIREILYHV 171
Cdd:pfam06719  82 LLAELLLEAPPPGP--PPRAGRGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRL 144
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
207-288 1.96e-27

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 101.86  E-value: 1.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768   207 NLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTP 286
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 505384768   287 GE 288
Cdd:smart00342  81 SE 82
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
139-294 2.63e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 101.78  E-value: 2.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 139 ILCAIERLLDVMERPLDARILGKQIIREILYHVLLGPGGGALLALVSRQTHFSLISRVLKRIESQYTENLSVDQLAAEAN 218
Cdd:COG2207  100 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELG 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505384768 219 MSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGEDASRIR 294
Cdd:COG2207  180 LSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLR 255
HTH_18 pfam12833
Helix-turn-helix domain;
213-288 4.70e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 87.65  E-value: 4.70e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505384768  213 LAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKAR-MLMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGE 288
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARrLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSE 77
ftrA PRK09393
transcriptional activator FtrA; Provisional
 193-287 3.03e-12

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 65.76  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 193 ISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESAS 272
Cdd:PRK09393 220 LGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEE 299

                         90
                 ....*....|....*
gi 505384768 273 QFSREFKRYFGVTPG 287
Cdd:PRK09393 300 SLRHHFRRRAATSPA 314
 
Name Accession Description Interval E-value
AraC_N pfam06719
AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of ...
 28-171 1.58e-46

AraC-type transcriptional regulator N-terminus; This family represents the N-terminus of bacterial ARAC-type transcriptional regulators. In E. coli, these regulate the L-arabinose operon through sensing the presence of arabinose, and when the sugar is present, transmitting this information from the arabinose-binding domains to the protein's DNA-binding domains. This family might represent the N-terminal arm of the protein, which binds to the C-terminal DNA binding domains to hold them in a state where the protein prefers to loop and remain non-activating. All family members contain the pfam00165 domain.


Pssm-ID: 461994  Cd Length: 152  Bit Score: 153.43  E-value: 1.58e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768   28 LPDIRLLYGTQPGTRTPVMYQPGIVFLFSGHKIGYINERVFRYDTNEYLLLTVPLPFECE-TFATEEVPLAGIRVNVDIL 106
Cdd:pfam06719   2 IPGLTLFRTSEPTEPTPVVYEPSLCIVAQGAKRVHLGDETYEYDPGEYLVVSVDLPVTGEvTEASPEEPYLGLALDLDPA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505384768  107 QLQELLMEIGEDELfrPSMAASGINSATLSEEILCAIERLLDVMERPLDARILGKQIIREILYHV 171
Cdd:pfam06719  82 LLAELLLEAPPPGP--PPRAGRGLAVSPLDEELLDAVLRLLRLLDTPEDIPVLAPLILREILYRL 144
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
207-288 1.96e-27

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 101.86  E-value: 1.96e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768   207 NLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTP 286
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ..
gi 505384768   287 GE 288
Cdd:smart00342  81 SE 82
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
139-294 2.63e-25

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 101.78  E-value: 2.63e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 139 ILCAIERLLDVMERPLDARILGKQIIREILYHVLLGPGGGALLALVSRQTHFSLISRVLKRIESQYTENLSVDQLAAEAN 218
Cdd:COG2207  100 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELG 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505384768 219 MSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGEDASRIR 294
Cdd:COG2207  180 LSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLR 255
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 184-299 5.43e-23

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 96.38  E-value: 5.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 184 VSRQTHFSLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAA 263
Cdd:COG4977  203 VPLGHRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIA 282

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 505384768 264 MRVGYESASQFSREFKRYFGVTPGEDASRIRTMQGA 299
Cdd:COG4977  283 AACGFGSASHFRRAFRRRFGVSPSAYRRRFRARAAA 318
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 192-288 1.94e-22

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 95.51  E-value: 1.94e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 192 LISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLmIHDGMKASAAAMRVGYESA 271
Cdd:COG2169   85 LVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQL-LQTGLSVTDAAYAAGFGSL 163

                         90
                 ....*....|....*..
gi 505384768 272 SQFSREFKRYFGVTPGE 288
Cdd:COG2169  164 SRFYEAFKKLLGMTPSA 180
HTH_18 pfam12833
Helix-turn-helix domain;
213-288 4.70e-22

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 87.65  E-value: 4.70e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505384768  213 LAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKAR-MLMIHDGMKASAAAMRVGYESASQFSREFKRYFGVTPGE 288
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARrLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSE 77
ftrA PRK09393
transcriptional activator FtrA; Provisional
 193-287 3.03e-12

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 65.76  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 193 ISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESAS 272
Cdd:PRK09393 220 LGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEE 299

                         90
                 ....*....|....*
gi 505384768 273 QFSREFKRYFGVTPG 287
Cdd:PRK09393 300 SLRHHFRRRAATSPA 314
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
193-288 1.29e-07

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 51.99  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 193 ISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESAS 272
Cdd:PRK13503 173 LNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSN 252

                         90
                 ....*....|....*.
gi 505384768 273 QFSREFKRYFGVTPGE 288
Cdd:PRK13503 253 HFSTLFRREFSWSPRD 268
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 194-288 1.89e-07

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 51.57  E-value: 1.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 194 SRVLKRI-ESQYTENLSVDQLAAEANMSVSAFHHNFkSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAA--AMRVGYES 270
Cdd:PRK09685 200 QKVVALIdQSIQEEILRPEWIAGELGISVRSLYRLF-AEQGLVVAQYIRNRRLDRCADDLRPAADDEKITsiAYKWGFSD 278

                         90
                 ....*....|....*...
gi 505384768 271 ASQFSREFKRYFGVTPGE 288
Cdd:PRK09685 279 SSHFSTAFKQRFGVSPGE 296
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
205-288 2.42e-07

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 51.13  E-value: 2.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 205 TENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESASQFSREFKRYFGV 284
Cdd:PRK10572 197 ASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGA 276


                 ....
gi 505384768 285 TPGE 288
Cdd:PRK10572 277 SPSE 280
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 200-241 5.18e-07

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 45.61  E-value: 5.18e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 505384768  200 IESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLK 241
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
191-288 1.49e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 48.94  E-value: 1.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 191 SLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYES 270
Cdd:PRK13500 206 TLLDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFED 285

                         90
                 ....*....|....*...
gi 505384768 271 ASQFSREFKRYFGVTPGE 288
Cdd:PRK13500 286 SNYFSVVFTRETGMTPSQ 303
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
188-286 5.04e-06

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 44.53  E-value: 5.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 188 THFSLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVG 267
Cdd:PRK10219   2 SHQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLG 81

                         90
                 ....*....|....*....
gi 505384768 268 YESASQFSREFKRYFGVTP 286
Cdd:PRK10219  82 YVSQQTFSRVFRRQFDRTP 100
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 189-288 6.48e-06

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 46.84  E-value: 6.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 189 HFSLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSvTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGY 268
Cdd:PRK09978 140 QPNMRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLRE-EETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGY 218

                         90       100
                 ....*....|....*....|
gi 505384768 269 ESASQFSREFKRYFGVTPGE 288
Cdd:PRK09978 219 HSVSYFIYVFRNYYGMTPTE 238
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
188-288 1.12e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 46.20  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 188 THFSLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVG 267
Cdd:PRK13502 173 SRETLLDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCG 252

                         90       100
                 ....*....|....*....|.
gi 505384768 268 YESASQFSREFKRYFGVTPGE 288
Cdd:PRK13502 253 FEDSNYFSVVFTRETGMTPSQ 273
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
186-298 1.62e-05

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 43.55  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 186 RQTHFSLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMR 265
Cdd:PRK11511   4 RNTDAITIHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAER 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 505384768 266 VGYESASQFSREFKRYFGVTPGEdaSRIRTMQG 298
Cdd:PRK11511  84 YGFESQQTLTRTFKNYFDVPPHK--YRMTNMQG 114
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
208-286 2.08e-05

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 45.55  E-value: 2.08e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384768 208 LSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHdGMKASAAAMRVGYESASQFSREFKRYFGVTP 286
Cdd:PRK15435 100 VTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAK-GESVTTSILNAGFPDSSSYYRKADETLGMTA 177
PRK10371 PRK10371
transcriptional regulator MelR;
184-286 5.16e-05

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 44.04  E-value: 5.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 184 VSRQTHFsLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAA 263
Cdd:PRK10371 185 VSRHAQF-YVSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIA 263

                         90       100
                 ....*....|....*....|...
gi 505384768 264 MRVGYESASQFSREFKRYFGVTP 286
Cdd:PRK10371 264 LTAGFRSSSRFYSTFGKYVGMSP 286
PRK10130 PRK10130
HTH-type transcriptional regulator EutR;
184-286 1.12e-04

HTH-type transcriptional regulator EutR;


Pssm-ID: 182258 [Multi-domain]  Cd Length: 350  Bit Score: 43.37  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 184 VSRQTHFSLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASA-- 261
Cdd:PRK10130 233 ISHQSYRRLLSRAREYVLENMSEPVTVLDLCNQLHVSRRTLQNAFHAILGIGPNAWLKRIRLNAVRRELISPWSQSTTvk 312

                         90       100
                 ....*....|....*....|....*.
gi 505384768 262 -AAMRVGYESASQFSREFKRYFGVTP 286
Cdd:PRK10130 313 dAAMQWGFWHLGQFATDYQQLFAEKP 338
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 184-286 1.29e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 43.06  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 184 VSRQTHFSLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLkTYRLHKARMLMIHDGMKASAAA 263
Cdd:PRK15185 199 ILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYL-SARMNQAAKLLRIGNHNVNAVA 277

                         90       100
                 ....*....|....*....|...
gi 505384768 264 MRVGYESASQFSREFKRYFGVTP 286
Cdd:PRK15185 278 LKCGYDSTSYFIQCFKKYFKTTP 300
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
196-286 7.23e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 40.66  E-value: 7.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 196 VLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTYRLHKARMLMIHDGMKASAAAMRVGYESASQFS 275
Cdd:PRK13501 181 IMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFS 260

                         90
                 ....*....|.
gi 505384768 276 REFKRYFGVTP 286
Cdd:PRK13501 261 AVFTREAGMTP 271
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 253-288 7.75e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 36.36  E-value: 7.75e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 505384768  253 IHDGMKASAAAMRVGYeSASQFSREFKRYFGVTPGE 288
Cdd:pfam00165   5 LSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQ 39
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 191-288 4.03e-03

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 38.12  E-value: 4.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384768 191 SLISRVLKRIESQYTENLSVDQLAAEANMSVSAFHHNFKSVTSTSPLQYLKTyRLHKARMLMIHDGMKASAAAMRVGYES 270
Cdd:PRK15186 181 TLAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNA-RMNKATKLLRNSEYNITRVAYMCGYDS 259

                         90
                 ....*....|....*...
gi 505384768 271 ASQFSREFKRYFGVTPGE 288
Cdd:PRK15186 260 ASYFTCVFKKHFKTTPSE 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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