|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
17-412 |
2.46e-122 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 360.88 E-value: 2.46e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 17 LGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAG 96
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 97 SWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFA 176
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 177 WAMAWLIFYKHPRDQKKLSDEERDYIINGQ----ESQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPL 252
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGllaeQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 253 FMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWfGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALL 332
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRR-GKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 333 CIGGFAHQsLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIG-FSPLFAVLAIFDLMGAVVIWTV 411
Cdd:TIGR00893 320 ALGFFGLG-AGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVVAALALIGALSYLLL 398
|
.
gi 505384840 412 L 412
Cdd:TIGR00893 399 V 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
8-411 |
1.05e-89 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 275.99 E-value: 1.05e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAV 87
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 168 IISGVLSFAWAMAWLIFYkhprdqkklsdeerdyiingqesqhqtdngkkmsvwqilgtRQFWGIALPRFLAEPAWGTFN 247
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL-----------------------------------------RQVWGLALGYFGINYALYGLL 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWfgvnliVSRKMVVTMGALLMIGPGMIGLFTSPYV 327
Cdd:cd17319 200 TWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG------ARRLVIIIGLLLAAVGLLLAYLTTSPVV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 328 AIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALAD-TIGFSPLFAVLAIFDLMGAV 406
Cdd:cd17319 274 AVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAAFLFLAAVALLAAL 353
|
....*
gi 505384840 407 VIWTV 411
Cdd:cd17319 354 LVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-413 |
1.21e-64 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 211.65 E-value: 1.21e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 1 MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAF 80
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 81 FAVAWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 161 HSWQMAFIISGVLSFAWAMAwlifykhprdqkklsdeerdyiingqesqhqtdngkkmsvwqilgtrQFWGIALPRFLAE 240
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL-----------------------------------------------RFWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 241 PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnliVSRKMVVTMGALLMIGPGMIG 320
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR-------RRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 321 LFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIF 400
Cdd:COG2271 267 LLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
410
....*....|...
gi 505384840 401 DLMGAVVIWTVLK 413
Cdd:COG2271 347 ALLAALLALLLLR 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-413 |
6.31e-43 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 155.04 E-value: 6.31e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAV 87
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 168 IISGVLSFAWAMAWLIFYKHPrdqkklsdeerdyiingQESQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFN 247
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDP-----------------PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 248 AWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKMVVTMGALLMIGPGMIGLFT-SPY 326
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG---------RRVLLIVFALMALGLLLLALALgSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 327 VAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIG-FSPLFAVLAIFDLMGA 405
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVAL 376
|
....*...
gi 505384840 406 VVIWTVLK 413
Cdd:COG2223 377 VLTLLLYR 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-376 |
2.22e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 128.17 E-value: 2.22e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 1 MRKIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAF 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 81 FAVAWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 161 HSWQMAFIISGVLSFAwAMAWLIFYKHprdqkklsdeerdyiingqESQHQTDNGKKMSVWQILGTRQFWGIALPRFLAE 240
Cdd:COG2814 161 FGWRWVFLVNAVLALL-ALLLLLRLLP-------------------ESRPAARARLRGSLRELLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 241 PAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKMVVTMGALLMIGPGMIG 320
Cdd:COG2814 221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR---------RRLLLIGLLLLALGLLLLA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 505384840 321 LFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTL 376
Cdd:COG2814 292 LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-378 |
3.49e-31 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 122.14 E-value: 3.49e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 15 VTLGTVLGYLTRNTVAAAAP-TLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 94 LAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVL 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 174 SFAWAMAWLIFYKHPRDQKKLSDEERDYIIngqesqhqtdngkkMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLF 253
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSL--------------IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 254 MfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLmigpgmIGLFTSPYVAIALLC 333
Cdd:pfam07690 227 Q-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL------LSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 505384840 334 IGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFA 378
Cdd:pfam07690 300 LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
34-409 |
6.24e-31 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 121.91 E-value: 6.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEA 113
Cdd:cd17325 20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAwAMAWLIFYKHPRdqkk 193
Cdd:cd17325 100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL-ALVLALLLLPEP---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 194 lsdeerdyiINGQESQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPM 273
Cdd:cd17325 175 ---------RPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 274 LFADLGCIVGGYLPplfqRWFGvnlivsRKMVVTMGALLM-IGPGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSD 352
Cdd:cd17325 246 LASALSQPPAGKLS----DRIG------RKPLILIGLLLSaVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 505384840 353 VFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIFDLMGAVVIW 409
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
16-394 |
8.53e-29 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 116.32 E-value: 8.53e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 16 TLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALA 95
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 96 GSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH-SWQMAFIISGVLS 174
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 175 FAWAMAWLIFYKHPRDQKKLSDEERDYIINGQESQHQTDNG---KKMSVWQILGTRQFWGIALPR-FLAEPAWGtFNAWI 250
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEEltkKQIFLQYVLLNKVLWYISLGYvFVYVVRTG-ILDWS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 251 PLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLF--QRWFGVNLIVSRKMVVTMGALLMIgpgmigLFTSPYVA 328
Cdd:TIGR00881 240 PLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLN------PAANPLMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384840 329 IALLCIGGF---AHQSLSGaliTLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLF 394
Cdd:TIGR00881 314 LICLFALGFlvyGPQMLIG---VIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-409 |
3.68e-27 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 111.75 E-value: 3.68e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATAL 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAI--VMHSWQMAFIISGV 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 173 LSFAWAMAWLIFYKHPRDQKKLSDEERDYIINGQesqhqtdngkkmSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPL 252
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLK------------LLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 253 FMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGylpplfqrWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALL 332
Cdd:cd06174 229 FLLDLGGLSVAVAGLLLSLFGLAGALGSLLLG--------LLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505384840 333 CIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALAD-TIGFSPLFAVLAIFDLMGAVVIW 409
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
11-409 |
6.46e-24 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 102.70 E-value: 6.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 11 MIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCG 90
Cdd:cd17318 22 IVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 91 ATALA--GSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFI 168
Cdd:cd17318 102 LTPLAarGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFY 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 169 ISGVLSFAWAMAWLIFykhprdqkklsdeerdyiingqesqhqtdngkkmsvwqilgTRQFWGIALPRFLAEPAWGTFNA 248
Cdd:cd17318 182 IFGGLGLLWCLLWFFL-----------------------------------------VLPVWAIVVAHFGHNWGFYTLLT 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 249 WIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMG----ALLMIGPGMIGlfTS 324
Cdd:cd17318 221 ELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFTSIGflgpGVFLIALGYLG--SN 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 325 PYVAIALLCI----GGFAHQSLSGALITLSSDVFGrnevaTANGLTGMAAWTASTLFALVVGAL---ADTIG-FSPLFAV 396
Cdd:cd17318 299 ATLAVVFLTLsvglSGACYSGFLVNHLDLAPNYAG-----TLMGITNTAATIAGIISPLIVGAIvknDQTIGqWRIVFFI 373
|
410
....*....|...
gi 505384840 397 LAIFDLMGAVVIW 409
Cdd:cd17318 374 SAAIYILGAIFYL 386
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
5-418 |
1.48e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 101.47 E-value: 1.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 5 KGLRWYMIALVTLGTVLGYLTrNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVA 84
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFAT-ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 85 WAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIaVGYFNVGSSIGAMIAPPLVVWAIVMH--- 161
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASR-LNLLHAFFSLGALLGPLLGGLLILLGlsl 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 162 SWQMAFIISGVLSFAwAMAWLIFYKHPRDQKKLSDEErdyiingqesqhqtdnGKKMSVWQILGTRQFWGIALPRFLAEP 241
Cdd:COG0738 162 SWHLPYLILAVLLLL-LALLFLRSKLPEIEEEEEEAA----------------GSAASLKSLLKNPRLLLGGLAIFLYVG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 242 AWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGPGMIGL 321
Cdd:COG0738 225 AEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFL---------LKRFGPVRLLRLSALLAAVGLLLALL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 322 FTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAwTASTLFALVVGALADTIGFSPLFAVLAIFD 401
Cdd:COG0738 296 APGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCY 374
|
410
....*....|....*..
gi 505384840 402 LMGAVVIWTVLKSKSAD 418
Cdd:COG0738 375 LLILLLALALKRKRRKK 391
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
12-407 |
4.79e-21 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 93.77 E-value: 4.79e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGA 91
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 92 TALAGSWG--GLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFII 169
Cdd:cd17380 81 TPLLAYSSlpLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 170 SGVLSFAWAMAWLIFYkhprdqkklsdeerdyiingqesqhqtdngkkmsvwqilgtRQFWGIALPRFLAepAWGTFN-- 247
Cdd:cd17380 161 FGLLGLLWALVWLIYL-----------------------------------------PPVWAIIVAHFCM--NWGFYIll 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 248 AWIPLFmFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwFGVNLIVSRKMVVTMGallMIGPGM----IGLFT 323
Cdd:cd17380 198 SWLPTY-FHEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLIS-RGWTVTSVRKLMQSIG---FLGPALflllLSHTD 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 324 SPYVAIALLCIG-GFAHQSLSGALITL-------SSDVFG-RNEVATANGLTGMAawtastlfalVVGALADTIG-FSPL 393
Cdd:cd17380 273 SFSLALLCMSVAlGLSAFSSSGVLVNHqdiapnyAGIVFGiSNTAGTIPGIVGVY----------LTGYILEATGsWSLV 342
|
410
....*....|....
gi 505384840 394 FAVLAIFDLMGAVV 407
Cdd:cd17380 343 FVLAAVVNLVGAVV 356
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
13-385 |
3.41e-20 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 91.91 E-value: 3.41e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 13 ALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGAT 92
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 93 ALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAppLVVWAIVMH---SWQMAFII 169
Cdd:cd17328 82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLG--YVVGGLVAQatgGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 170 SGVLSFAWAMAWLIFYKHPRdqKKLSDEERDyiingqesQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAW 249
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPP--RGAAEGGVM--------AKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 250 IPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMI---GPGMIGLFTSPY 326
Cdd:cd17328 230 APTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAApflFLALVLALSNLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 327 VAIALLCIGGFAH-----------------------------------QSLSGALITLSSDVFGRNEVATANGLTGMAAW 371
Cdd:cd17328 310 LAWVLLFLGEFLLslnwapvfaillyvviptrrstasaiqillshllgDAGSPYLIGLISDLLRQNKDSPLAEAASLQYA 389
|
410
....*....|....
gi 505384840 372 TASTLFALVVGALA 385
Cdd:cd17328 390 LLLCSFVLVLGGFF 403
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
49-412 |
1.14e-19 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 90.96 E-value: 1.14e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 49 YIIAAYSAAYTVMQPVAGYVLDILGTK--IGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEW 126
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKwsIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 127 FPAKERSIAVGYFNVGSSIGAMIAPPLVVW-AIVMHSWQMAFIISGVLSFAWAMAWLIF-YKHPRDQKKLSDEERDYiIN 204
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWlCESWGGWPMIFYVFGIVGCAWSLLWFVFpADDPSIHPCISKFEKKY-IN 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 205 GQESQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGG 284
Cdd:TIGR00894 239 SSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAG 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 285 YLPPLFQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSP--YVAIALLCI-GGFAHQSLSGALItLSSDVFGRnevat 361
Cdd:TIGR00894 319 YLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAafYLTIIILTLaNAVSSGPLAGVLI-NSLDLAPR----- 392
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 505384840 362 ANGLTGMAAWTASTLFALVVGALADTI-GFSPLFAVLAIFDLMGAVVIWTVL 412
Cdd:TIGR00894 393 FLGFIKGITGLPGFIGGLIASTLAGNIlSQDSKNVWLIVFLIMAFVNILCVI 444
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
8-400 |
1.27e-19 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 90.38 E-value: 1.27e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----IGYAFFAV 83
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKrflaIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 84 AWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM--- 160
Cdd:cd17345 81 INILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIfgd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 161 HSWQMAFIISGVLSFAWAMAWLiFYKHPRDQKKLSDEERDYIINGQESQHQTDNGKKMSVWQI-----LGTRQFWGIALP 235
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVL-FLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAWEIfvkyvLKNKLLWYIAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 236 R-FLAEPAWGTFNaWIPLFMFKVYGFNLKE----IAMFAWMpmlfADLGCIVGGYLPPLFQRwfgvnlivSRKMVVTMGA 310
Cdd:cd17345 240 NvFVYLVRYGILD-WAPTYLSEVKGFSKAQamwaFSLFEWA----AIPGTLLAGWLSDKLFK--------GRRAPTGIIF 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 311 LLMIGPGMIGLFTSPYV---AIALLCIGGFAHQSLsgALITLSS-DVFGRNEVATANGLTGMAAWTASTLFA-LVVGALA 385
Cdd:cd17345 307 MILVIVALIVYWLAPNVlvdLIALIALGFLIYGPV--MLIGLQAlELVPKKAAGTAAGLTGLFGYLGGSVLAtALIGIIV 384
|
410
....*....|....*
gi 505384840 386 DTIGFSPLFAVLAIF 400
Cdd:cd17345 385 DHFGWNGGFIVLLAS 399
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-411 |
3.51e-19 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 88.40 E-value: 3.51e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGA 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 92 TALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGaMIAPPLVVWAIVMHSWQMAFIISG 171
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLG-IAVGPLLGGLLAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 172 VLSFAWAMAWLIFYKHPRdqkklsdeerdyiingqESQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17474 160 ALIPVAFLAILFLLPEPK-----------------EKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFqrwfgvnliVSRKMVVTMGALLM-IGPGMIGLFTSPYVAIA 330
Cdd:cd17474 223 FLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKR---------FGARRILVIGLLLYaLSLLLLGFVPSLALLLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 331 LLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIFDLMGAVVIWT 410
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
.
gi 505384840 411 V 411
Cdd:cd17474 374 L 374
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-370 |
2.81e-18 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 86.15 E-value: 2.81e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLM-EELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAV 87
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMkEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIApPLVVWAIV-------M 160
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLAYGVFkilgvggL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 161 HSWQMAFIISGVLSFAWAMAwlIFYKHPRDQKK---LSDEERDYIINGQESQHQTDNGKKMS---VWQILGTRQFWGIAL 234
Cdd:cd17327 163 AGWRWLFIIEGLITIIIGLV--IFFWLPDNPSKawfLTEEEKELAVERLRANQTGKGDQKFKwkqIKEAFKDPRTWLLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 235 PRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQrwfgvnlivsRKMVVTMGALLMI 314
Cdd:cd17327 241 FFFCSQITNNGISNFLPLIL-KSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFK----------KRGLFAIFACVLA 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505384840 315 GPGMIGLFTSP-----YVAIALLCIGGFAHQSLSGALItlSSDVFGRNEVATANGLTGMAA 370
Cdd:cd17327 310 LVGSIILLAAPnppgaYFAAYILGGGSYAGFPILLSWI--SSNCAGYTKRATVLAIMLIFY 368
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-409 |
1.22e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 83.75 E-value: 1.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEA 113
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFawAMAWLIFYKHPRDQkk 193
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLLPSLP-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 194 lsdeerdyiingqeSQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFawmpM 273
Cdd:cd17324 179 --------------PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL----L 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 274 LFADLGCIVGGylpPLFQRWfgVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDV 353
Cdd:cd17324 241 LLFGVAGVVGS---PLAGRL--ADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 505384840 354 FGRNeVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIFDLMGAVVIW 409
Cdd:cd17324 316 APEA-RGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
8-412 |
1.25e-17 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 83.86 E-value: 1.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIgyafFAVAWAV 87
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRR----FMSAGLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGG----LALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSW 163
Cdd:cd17312 77 LSALANIFMGFSTslwfFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 164 QMAFIISGVLSFAWAmawLIFYKHPRDQKKLsdeerdyiingqesqhqtdngkkmsvwqilgtrqFWGIALPRFLAEPAW 243
Cdd:cd17312 157 RAAFLVPGIVGLVVA---IILFFFLRDSPPY----------------------------------VWVLSLAYAFVYIVR 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 244 GTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPplfQRWFGVNlivSRKMVVTMGALLMIGPGMIGLFT 323
Cdd:cd17312 200 YACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLS---DKLFGGR---RAPIAVIYMLLMTLSLALFWFFP 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 324 SPYV--AIALLCIGGF--AHQSLSGALItlSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAI 399
Cdd:cd17312 274 HNKLlsIVLLFLIGFFvgGPINLIGGAA--AQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLIS 351
|
410
....*....|...
gi 505384840 400 FDLMGAVVIWTVL 412
Cdd:cd17312 352 AALLSVLLLLSLW 364
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-409 |
1.29e-17 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 83.76 E-value: 1.29e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAV 108
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 109 GAAEAAMIPAGLKASSEwFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIV---MHSWQMAFIISGVLSFAWAMAWLIFY 185
Cdd:cd17478 95 GIGSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVAlfgGLGLLILLIIPGLAVALLLLRLRPLK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 186 KHPRDQKKLSDEERDYIingqesqhQTDNGKKMSVWQILGTRQFWGIALPRFLAepawgtfnawiplFMFKVYGFNLKEI 265
Cdd:cd17478 174 KPEAKKAAAKSSARSTL--------KGVWRALLLLLIIVFLRSWVLSSLTTFLP-------------FYLVQRGYSLVFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 266 AMFAWMPMLFADLGCIVGGYLPPLFqrwfgvnlivSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQSLSGA 345
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRF----------GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPV 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505384840 346 LITLSSDVFGRNeVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIFDLMGAVVIW 409
Cdd:cd17478 303 TVVLAQELLPGN-VGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
8-419 |
8.15e-17 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 81.84 E-value: 8.15e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAV 87
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 168 IISGVLSFAWAMAWLIFYKHPRdqkklsdeerdyiingqesQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFN 247
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRP-------------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 248 AWIPLfMFKVYGFNLkeiAMFAWMPMLFADLGCIVGGYLPPLFQRWFGVnlivsRKMVVTMGALLMIGPGMIGLF--TSP 325
Cdd:COG2807 236 AWLPP-ILRDAGLSA---ATAGLLLSLFQLAGIPGSLLVPLLADRLGDR-----RPLLLLLGLLGLAGLLGLLLApgSLP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 326 YVAIALLCIGGFAHQSLSGALITLSSDvfGRNEVATANGLTGMAAWTASTLFALVVGALAD-TIGFSPLFAVLAIFDLMG 404
Cdd:COG2807 307 WLWAVLLGLGQGGLFPLALTLIGLRAR--TPAEAAALSGMAQSVGYLLAALGPLLVGALHDaTGSWTAALLLLAALAVLM 384
|
410
....*....|....*
gi 505384840 405 AVVIWTVLKSKSADE 419
Cdd:COG2807 385 LVAGLLAGRPYVEDA 399
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
16-409 |
3.90e-16 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 79.59 E-value: 3.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 16 TLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALA 95
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 96 GSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGY----FNVGSSIGAMIAPPLVvwaiVMHSWQMAFIISG 171
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIrqtgVPLGGALAAALLPPLA----LHYGWRAAFVVAG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 172 VLSFAWAMAWLIFYKHPRDQKklsdeerdyiingqeSQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17475 158 LVSILAAVLFWLFYREPPAAS---------------AATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPplfQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIAL 331
Cdd:cd17475 223 LFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVS---DRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLL 299
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384840 332 LCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALAD-TIGFSPLFAVLAIFDLMGAVVIW 409
Cdd:cd17475 300 LILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
8-177 |
3.21e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 75.62 E-value: 3.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAV 87
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170
....*....|
gi 505384840 168 IISGVLSFAW 177
Cdd:COG0477 172 LINAPLGLLA 181
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-384 |
7.88e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 69.51 E-value: 7.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----IGYAFFAVAwavfCG 90
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKrvflIGLALFGLA----SL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 91 ATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS 170
Cdd:cd17321 77 LCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 171 GVLSFAwamawlifykhprdqkklsdeerdyiingqesqhqtdngkkmsvwQILGTRQFWGIALPRFLAEPAWGTFNAWI 250
Cdd:cd17321 157 VPIGLV---------------------------------------------ALLLARTFSGAVLAAFLLGAALGGLLFLL 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 251 PLFMFKVYGFNLKEIAMFawmpMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIgpGMIGLFTSPYVAIA 330
Cdd:cd17321 192 PLYLQGVLGYSPLQAGLA----LLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLL--ALLGADSSVWLLLP 265
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 505384840 331 LLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGAL 384
Cdd:cd17321 266 GLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
8-411 |
1.66e-12 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 68.41 E-value: 1.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAV 87
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAG-LKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMA 166
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITpVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 167 FIISGVLSFAWAMAWLIFYKHPRDQKKLSDEERDyiingqeSQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTF 246
Cdd:cd17353 160 FLILGIIFLIIIVIGAFLIRDPPKGWVPPGVDPL-------ANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLML 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 247 NAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFqrwfgvnlivSRKMVVTMgALLMIGPGMIGLFTSPY 326
Cdd:cd17353 233 IGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI----------GRKNTLSI-AFLIQGVAMFLLPFIGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 327 VAIALL---CIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIFDLM 403
Cdd:cd17353 302 VAVLFVlgvALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLV 381
|
....*...
gi 505384840 404 GAVVIWTV 411
Cdd:cd17353 382 ALALALLL 389
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-176 |
4.82e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 67.22 E-value: 4.82e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKigyAFFAVAWAVFCGAT-- 92
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTR---RLFLTALALFTLGSll 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 93 -ALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS- 170
Cdd:cd17503 78 cGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINl 157
|
....*...
gi 505384840 171 --GVLSFA 176
Cdd:cd17503 158 piGILALL 165
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-409 |
4.88e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 66.85 E-value: 4.88e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 15 VTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATAL 94
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLS 174
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 175 F-AWAMAWLIFYKHPRdqkklsdeerdyiingqesqHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLF 253
Cdd:cd17489 161 LlALLLVFLVKDPPPV--------------------AAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 254 MFKVygfNLKEIAMFawmpMLFADLGCIVGGYLPPLFQRWFGvnlivsRKMVVTMGALLM-IGPGMIGLFTSPYVAIALL 332
Cdd:cd17489 221 AAER---GISNAGLF----FTVYAIALLLSRPFSGKLSDRKG------PKTVIIPGLLLLaLGLLLLSFAGSPWMLLLAA 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505384840 333 CIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIFDLMGAVVIW 409
Cdd:cd17489 288 VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
14-412 |
1.57e-11 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 65.35 E-value: 1.57e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 14 LVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATA 93
Cdd:cd17341 3 LSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 94 LAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKER----SIAVGYFNVGSSIGAMIAPPLVVWAIVMHS---WQMA 166
Cdd:cd17341 83 LAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIggaaGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGfvgWRNA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 167 FIISGVLSFAWAMAWLIFYKHPRDQKKLSDEerdyiingqesqhqtdngKKMSVWQILGTRQFWGIALPRFLAEPAWGTF 246
Cdd:cd17341 163 FFVPGILLAIAAVLVLLFGDDLPTGKASALE------------------FLKVQLAVLKNYRTWILSLLYGVTFGSFVGF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 247 NAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLF--QRWFGVNLIVsrkMVVTMGALLMIGPGMIGLFTs 324
Cdd:cd17341 225 SNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFggRRRLWWLFIV---MTIGAALLSLSLPTSGTNLV- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 325 pyVAIALLCIGGFAHQSLSGALITLSSDVFgRNEVATANGLTGMAAWTASTLFALVVGALADTIGfSPLFAVLAIFDLMG 404
Cdd:cd17341 301 --LFLALFVALGLGAGAGNGSVFRMVPFIF-RRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTG-SGVGAFSLFGVLAV 376
|
....*...
gi 505384840 405 AVVIWTVL 412
Cdd:cd17341 377 ACTLLVWL 384
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
36-411 |
3.87e-11 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 64.21 E-value: 3.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 36 LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEAAM 115
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 116 IPAGLKAS-SEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAM-AWLIFYKHPRDQKK 193
Cdd:cd17355 109 LAAVAFATvAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVpVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 194 LSDEERDYIINGqesqhqtdngkkMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPM 273
Cdd:cd17355 189 RAYDDASPASPG------------STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL-ADRGISPAAAAVALALIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 274 LFADLGCIVGGYlppLFQRWFgvnlivSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIG-GFAHQSLSGALITLSSD 352
Cdd:cd17355 256 LFNIVGRLLSGW---LGDRYS------PRRLLAASYALRALGLALLLLLPFPPLALLLFAALfGLGWGATVPLTAALAAR 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 353 VFGRNEVATANGLTGMAAWTASTLFALVVGALADTIG-FSPLFAVLAIFDLMGAVVIWTV 411
Cdd:cd17355 327 YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
7-185 |
2.25e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.82 E-value: 2.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 7 LRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEEL-HISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAW 85
Cdd:cd17325 196 LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 86 AVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQM 165
Cdd:cd17325 276 AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355
|
170 180
....*....|....*....|
gi 505384840 166 AFIISGVLSFAWAMAWLIFY 185
Cdd:cd17325 356 PFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-409 |
6.82e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 60.31 E-value: 6.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELhiSTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIG----YAFFAVAWAV 87
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF--SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGrkkaLILTLLLFGL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPpLVVWAIVMH-----S 162
Cdd:cd17316 79 ATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAA-LVASLLIPLlsgdwG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 163 WQMAFIISGVLSFawaMAWLIFykhprdqkklsdeerdyiingqesqhqtdngkkmsvwqilgtRQFWGIALPRFLAEPA 242
Cdd:cd17316 158 WRILFLIGALPAL---LALLLR------------------------------------------RRTLLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 243 WGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKMVVTM--GALLMIGPGMIG 320
Cdd:cd17316 193 YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR---------KKTLVIGliLSGILALPLFYL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 321 LFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIF 400
Cdd:cd17316 264 LSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
....*....
gi 505384840 401 DLMGAVVIW 409
Cdd:cd17316 344 LAIVALIVA 352
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-189 |
3.02e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 3.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 9 WYMIALVTLGTVLGYLTRNTVAAAAPT-LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILG--TKIGYAFFAVAW 85
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 86 AVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQM 165
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|....
gi 505384840 166 AFIISGVLSFAWAMAWLIFYKHPR 189
Cdd:COG2271 339 AFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
15-409 |
6.26e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 57.19 E-value: 6.26e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 15 VTLGTVLGYLTRNTVAAAAPTLMEELHiSTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATAL 94
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 95 AGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS---G 171
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINlpiG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 172 VLSFAwamawlifykhprdqkklsdeerdyiingqesqhqtdngkkmsvwqilGTRQFWGIALPRFLAEPAWGTFNAWIP 251
Cdd:cd17502 160 GLALA------------------------------------------------LLRTILLSSIFGFLFGGALFGLIYYLP 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 252 LFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYlppLFQRWFGV-NLIVSRKMVVTMGALLMIgpgMIGLFTSPYVAIA 330
Cdd:cd17502 192 LYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGA---LISKTGRYkPLIVIGTILMSVGAGLLT---TLTLDTSKWLLIG 265
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384840 331 LLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFalvvgaladtIGFSPLFAVLAIFDLMGAVVIW 409
Cdd:cd17502 266 YLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG----------VAITDVFLVALALAALAFLLSL 334
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
9-364 |
9.13e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.98 E-value: 9.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVF 88
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 89 CGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFI 168
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 169 ISGVLSFAwaMAWLIFYKHPRDQKKL---SDEERDYIINGQESQHQTDNGKKMSVwQILGTRQFWGIALPRFLAEPAWGT 245
Cdd:TIGR00895 176 VGGIAPLL--LLLLLMRFLPESIDFLvskRPETVRRIVNAIAPQMQAEAQSALPE-QKSTQGTKRSVFKALFQGKTARIT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 246 FNAWIPLFM--FKVYGFNlkeiamfAWMPMLFADLG------------CIVGGYLPPLFqrwFGVNLIVSRKMVVTMGAL 311
Cdd:TIGR00895 253 VLLWLLYFMllVGVYFLT-------NWLPKLMVELGfslslaatggalFNFGGVIGSII---FGWLADRLGPRVTALLLL 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 505384840 312 L--MIGPGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANG 364
Cdd:TIGR00895 323 LgaVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVG 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
227-424 |
4.61e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 54.89 E-value: 4.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 227 RQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvnlivsRKMVV 306
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYLWSVLAPPLA-EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP---------RRVLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 307 TMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALAD 386
Cdd:COG2223 75 IGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA 154
|
170 180 190
....*....|....*....|....*....|....*...
gi 505384840 387 TIGFSPLFAVLAIFDLMGAVVIWTVLKSKSADELAKES 424
Cdd:COG2223 155 AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK 192
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
29-408 |
1.21e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 53.36 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAV 108
Cdd:cd17365 18 MGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 109 GAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAMAwlifykhp 188
Cdd:cd17365 98 GLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL-------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 189 rdqkklsdeerdyiingqesqhqtdngkkmsvwqILGTRQFWGIAlprFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMF 268
Cdd:cd17365 170 ----------------------------------LRGTLLLWVTF---FMGLLLVYLLNSWLPKLM-VEAGYSLSQALTI 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 269 AWMPMLFADLGCIVGGYLpplfQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSpYVAIALLCIGGFAHQSLsgaLIT 348
Cdd:cd17365 212 TLLLNIGGVIGSLLLGWL----ADRFGPKRVLALFFALGAVSLALLGVSPASLVLL-YVLVFLAGACVNGAQVG---LYA 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505384840 349 LSSDVFGRNEVATANGLTGMAAWTASTLFALVVGAL-ADTIGFSPLFAVLAIFDLMGAVVI 408
Cdd:cd17365 284 LAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLlAAGLGPESVFLALAIPAALGALAV 344
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-410 |
1.89e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.61 E-value: 1.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 38 EELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEAAMIP 117
Cdd:cd17329 28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 118 AGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWaIVMHSWQMAFIISGVLSFAwAMAWLIFYKHPRdqkklsde 197
Cdd:cd17329 108 ASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL-LLLYSFRLLFLAAAVLFLL-AALVLLFLLPET-------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 198 erdyiINGQESQHQTDNGKkmSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKeiaMFAWMPMLFAD 277
Cdd:cd17329 178 -----RPKRRAAEKTEILR--GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES---LLGLLLALNAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 278 LGCIVGGYLPPLFQRWfgvnlivSRKMVVTMGALLM-IGPGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGR 356
Cdd:cd17329 248 LIVLLQFPVARLVERF-------RLRKILMIGILLFaIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 505384840 357 NEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIFDLMGAVVIWT 410
Cdd:cd17329 321 DKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLG 374
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
12-176 |
1.95e-07 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 52.58 E-value: 1.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGA 91
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 92 TALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISG 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
....*
gi 505384840 172 VLSFA 176
Cdd:cd17323 161 IISGF 165
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
9-182 |
2.17e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.60 E-value: 2.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 9 WYMIALVTLGTVLGYLTRNTVAAAAPTLMEE-LHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAV 87
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGL--KASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIV-MHSWQ 164
Cdd:cd17316 256 LALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAlyAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAsTGGTG 335
|
170
....*....|....*...
gi 505384840 165 MAFIISGVLSFAWAMAWL 182
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
49-391 |
3.24e-07 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 52.09 E-value: 3.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 49 YIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGG--LALARGAVGAAEAAMIPAGLKASSEW 126
Cdd:cd17381 69 WILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAVRALEGLGEGVTFPAMHAMWASW 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 127 FPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAMAWLIFykhprdqkklsdeerdyiingq 206
Cdd:cd17381 149 APPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWL---------------------- 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 207 esqhqtdngkkmsvwqilgTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYL 286
Cdd:cd17381 207 -------------------VMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 287 PPLFQRWFGVNLIVSRKMVVTMGallMIGPGMIGL---FTSPYVAIALlciggfAHQSLSGALITLSSDVFGRNEVATAN 363
Cdd:cd17381 268 ADNLREKQNFSTVCVRKIFTLIG---MIGPAVFLLaagFTGCNYSLAV------AFLTISSTLGGFSASGFNINHLDIAP 338
|
330 340
....*....|....*....|....*...
gi 505384840 364 GLTGMAAWTASTlFALVVGALADTIGFS 391
Cdd:cd17381 339 SYAGILLGITNT-FATIPGMVGPVIAKS 365
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
10-386 |
6.10e-07 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 51.59 E-value: 6.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 10 YMIALVTLGTVlgYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK--IGYAFFAVAWAV 87
Cdd:PRK09556 31 YLVVFIGYLTM--YLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKqfLPFLLILSAICM 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAG---SWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVW-AIVMHSW 163
Cdd:PRK09556 109 LGFGASLGSgsvSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWgANYFFDG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 164 QMA--FIISGVLSFAWAMAWLIFYKHPRDQKKLSDEERDYIINGQESQHQTDNgKKMSVWQI-----LGTRQFWGIALPR 236
Cdd:PRK09556 189 HVIgmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETES-TDMTKWQIfveyvLKNPVIWLLCFAN 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 237 FLAEPAWGTFNAWIPLFMFKVYGFNlKEIAMfawMPMLFADLGCIVG----GYLPplfqrwfgvNLIVSRKMVVTMGALL 312
Cdd:PRK09556 268 IFLYIVRIGIDNWSPVYAFQELGFS-KEDAI---NTFTLFEIGALVGsllwGWLS---------DLANGRRALVACIALA 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 313 MIGpGMIGLF---TSPYVAIALLCIGG---FAHQSLSG-ALITLSSdvfgRNEVATANGLTGMAAWTASTLFALV-VGAL 384
Cdd:PRK09556 335 LII-FTLGVYqhaTSEYMYLASLFALGflvFGPQLLIGvAAVGFVP----KKAIGVANGIKGTFAYLFGDSFAKVgLGMI 409
|
..
gi 505384840 385 AD 386
Cdd:PRK09556 410 AD 411
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
65-408 |
9.63e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 50.76 E-value: 9.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 65 AGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSS 144
Cdd:cd17371 54 GGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 145 IGAMIA----PPLVVWAIVMHSWQMAFIISGVLSFawaMAWLIfykhprdQKKLSDEERdyiinGQESQHQTDNGKKMSV 220
Cdd:cd17371 134 VGWLLAtllaALLFPLLPPEIAWRVLFLLGALPAL---LVLFI-------RRFVKEPPQ-----WQAARAARRHFADRPS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 221 WQILGTRQFWGIALPRFL----AEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgv 296
Cdd:cd17371 199 LRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGR---- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 297 nlivsRKMVVTMGALLMIG-PGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTAST 375
Cdd:cd17371 275 -----RNNFALFALGSAISiLLYFFLPLSPTLILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGA 349
|
330 340 350
....*....|....*....|....*....|...
gi 505384840 376 LFALVVGALADTIGFSPLFAVLAIFDLMGAVVI 408
Cdd:cd17371 350 LFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVL 382
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-192 |
1.23e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 50.26 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTrntVAAAAPT-LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGY-AFFAVAW 85
Cdd:COG2223 206 RFWLLSLLYFGTFGSFIG---FSSWLPPyLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLlIVFALMA 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 86 AVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM-HSWQ 164
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtGSYT 362
|
170 180
....*....|....*....|....*...
gi 505384840 165 MAFIISGVLSFAWAMAWLIFYKHPRDQK 192
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
32-410 |
1.61e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 32 AAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----IGYAFFAVAWAVFCGATALAG-SWGGLALARG 106
Cdd:cd06173 21 ALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRrlliLADLLRALLAAVLALLALLGSlSLWLLLVLAF 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 107 AVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSF-AWAMAWLIFY 185
Cdd:cd06173 101 LLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLlSALLLLFIRR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 186 KHPRDQKKLSDEERDYIINGqesqhqtdngkkmsVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLkei 265
Cdd:cd06173 181 PPPAAPGESSSLLLRDLREG--------------LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGA--- 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 266 AMFAWMPMLFAdLGCIVGGYLPPLFQRWFGvnlivSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQSLSGA 345
Cdd:cd06173 244 AGYGLLLAAFG-VGALLGALLLGRLSKRRR-----RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVP 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505384840 346 LITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIFDLMGAVVIWT 410
Cdd:cd06173 318 LNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
8-186 |
4.25e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 48.48 E-value: 4.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK-------IGYAF 80
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARwlfssglVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 81 FAVAWAVFCGATALAGSWGGLALARGAVGAAEAAMipagLKAsseWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM 160
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKI----LRK---WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALS 153
|
170 180
....*....|....*....|....*.
gi 505384840 161 HSWQMAFIISGVLSFAWAMAWLIFYK 186
Cdd:cd17343 154 YGWRSTLSISGTVAVVMSVVCLLFIK 179
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
9-408 |
4.51e-06 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 48.78 E-value: 4.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 9 WYMIALVTLGTVLGYLTRNTVAaaaPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIG----------- 77
Cdd:cd17313 1 LFLLGFGFFGIEFGWALENSYV---PPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGrrrpfilvgap 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 78 ---YAFFAVAWA-VFCGATALAGSWGGLALARGAVG----AAEAAMIPAglKA-SSEWFPAKERSIAVGYFN-------- 140
Cdd:cd17313 78 laaLGLILIPNAaDIGLALGDGPRTWALVLFVLGIVlldfAMNVCQGPV--RAlLPDLVPPEQRSKANGIINfmgglggv 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 141 VGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLsFAWAMAWLIFYkhprdqkklSDEERDYIINGQESQHQTDNGKKMSV 220
Cdd:cd17313 156 LGYLLGAILWDHNWFGFALGGNLKVPFYIGAII-LLVCVLVTLFF---------VKEPPLSPEAGEHSENPSLGEVLKSL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 221 WQILGT--RQFWGIALPRFLAEPAWGTFNAWIPLFM-FKVYGFNLKEIA-------MFAWMPMLFAdLGCIVGGYLPPLF 290
Cdd:cd17313 226 LKLLKImpRSLLRLLLVIFFWWIAFFPFELFFTDYMgEEVYHGTSAASShygagvrMGAWGLLIFS-LAFLIFSLPIGKL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 291 QRWFGvnlivsRKMVVTMGALLM-IGPGMIGLFTSPYVAIALLCIGG---FAHQSLSGALITLSSDVFGRNEvATANGLT 366
Cdd:cd17313 305 GKKIG------RKKVYLIGLVLFaVGMALMALVHNVTVALVLFALGGigwATININPYPLVSDYHSESGRGQ-GTDTGLL 377
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 505384840 367 GMAAWTASTLFALVVGALADTIGFSPLFAVLAIFDLMGAVVI 408
Cdd:cd17313 378 NLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGA 419
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
218-413 |
6.33e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.05 E-value: 6.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 218 MSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMfKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLPPLFQRwfgvn 297
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIA-ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGR----- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 298 livsRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLF 377
Cdd:COG2814 75 ----RRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALG 150
|
170 180 190
....*....|....*....|....*....|....*.
gi 505384840 378 ALVVGALADTIGFSPLFAVLAIFDLMGAVVIWTVLK 413
Cdd:COG2814 151 PLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
60-392 |
6.95e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 6.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 60 VMQPVAGYVLDILGTKIGY-----AFFAVAWAVFCGATALAGSWGG------LALARGAVGAAEAAMIPAGLKASSEWFP 128
Cdd:COG2211 61 ITDPLIGALSDRTRTRWGRrrpwiLIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 129 -AKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM------HSWQMAFIISGVLSFAwAMAWLIFYKHPRDQKKlsdeerdy 201
Cdd:COG2211 141 dYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLL-AFLLTFFGTKERPVPE-------- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 202 iingqesqhQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLkeiAMFAWMPMLFAdLGCI 281
Cdd:COG2211 212 ---------EEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSA---ALVGLLLALYF-LAAL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 282 VGGYLPPLFQRWFGvnlivsRKMVVTMGALLMIGpGMIGLF----TSPYVAIALLCIGGFAHQSLSGALITLSSDV---- 353
Cdd:COG2211 279 LGAPLWPRLAKRFG------KKKAFIIGLLLAAL-GLLLLFflgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdyd 351
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 505384840 354 ---FGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSP 392
Cdd:COG2211 352 ewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA 393
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
48-412 |
8.25e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 8.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 48 SYIIAAYSAAYTVMQPVAGYVLDILGTK----IGYAFFAvawavfcgataLAGSWGGLA-------LARGAVGAAEAAMI 116
Cdd:cd17473 38 PLLLTLPALFIALFAPLAGWLADRFGRKrlliAGLLLYG-----------IGGVAGLFLdslyallASRALLGIGVAGIM 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 117 PAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIApPLVVWAIVMHSWQMAFIISGVLSFAWAMAWLiFYKHPRDQKKlsd 196
Cdd:cd17473 107 TLATALIGDYFEGEERAKMLGLQSAAMSLGGVVF-LLLGGALAEIGWRAPFLVYLLALPVLILVLL-FLPEPARKSK--- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 197 eerdyiingqesqhqTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFA 276
Cdd:cd17473 182 ---------------SAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 277 dlgcIVGGYLPPLFQRWFGVnlivsRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAhqslSGALITLSSDVFGR 356
Cdd:cd17473 247 ----AIGALLFGRLKRRLGK-----RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLG----FGLLLPTLNSWAMS 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505384840 357 NEVATANGLtGMAAWTASTLFA-----LVVGALADTI-GFSPLFAVLAIFDLMGAVVIWTVL 412
Cdd:cd17473 314 LVPPELRGR-AMGIVTSAFFLGqflspLVLGPLVNLTgGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
3-184 |
1.06e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 3 KIKGLRWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHI-STQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFF 81
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 82 AVAWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM- 160
Cdd:cd17473 270 FALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLt 349
|
170 180
....*....|....*....|....
gi 505384840 161 HSWQMAFIISGVLSFAWAMAWLIF 184
Cdd:cd17473 350 GGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
23-411 |
1.57e-05 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 46.88 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 23 YLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLD-ILGTKIG---YAFFAVAWAVFCGATALAGSW 98
Cdd:cd17340 12 YFCYDNPAALQKQFIEDMDINTSQFMLLYSVYSWPNVVLCFFGGFLIDrVFGIRLGtiiFSLLVLIGQLIFALGALTNLF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 99 GGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIA----VGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF------- 167
Cdd:cd17340 92 WLMLVGRFIFGIGGESLAVAQNTYAVSWFKGKELNLVfglqLSFARIGSTVNFNVMPPIYKRISDFYSGYKSLgvalwig 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 168 IISGVLSFAWAMAWLIFykhprdqkklsDEERDYIINGQESQhqtdNGKKMSVWQILGTR-QFWGIALPRFLAEPAWGTF 246
Cdd:cd17340 172 AITCLFSLICAIILGLL-----------DKRAERILKKESNK----TGEVIKLSDVKDFPlSFWLICIICVFYYVAVFPF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 247 NAWIPLFMFKVYGFNLKEIAmfAWMPMLFadlgcIVGGYLPPLFQrwFGVNLIVSRKMVVTMGALLMIGPGMIGLFTS-- 324
Cdd:cd17340 237 IGLGTVFFEEKYGFSPSEAA--AVNSIVY-----IISAAASPVFG--FLVDKVGRNILWVLIALVITLLGHLLLAFTFvn 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 325 PYVAIallCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPL---FAVLAIFD 401
Cdd:cd17340 308 PLIAM---VIMGIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSILDKKGYLLLevfFIACLCVS 384
|
410
....*....|
gi 505384840 402 LMGAVVIWTV 411
Cdd:cd17340 385 LIALIILYLV 394
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
63-187 |
2.12e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.03 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 63 PVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVG 142
Cdd:cd17317 43 LLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLF 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 505384840 143 SSIGAMIAPplvVWAIVMHSWQM-AFIISG----VLSFAWAMAWLIFYKH 187
Cdd:cd17317 123 WALGYMLLA---LLAYLIRDWRWlQLAISLpgllFLLLLWWLPRRTIIVG 169
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
8-184 |
2.52e-05 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 46.24 E-value: 2.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAV 87
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAF 167
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170
....*....|....*..
gi 505384840 168 IISGVLSFAWAMaWLIF 184
Cdd:cd17488 161 YVPGIIAILMGI-VLCW 176
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
24-408 |
2.70e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.16 E-value: 2.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 24 LTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWG---- 99
Cdd:cd17333 10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYlfvv 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 100 GLALARGAVGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIvmhSWQMAFIISGVLSFAWAM 179
Cdd:cd17333 90 LMFLAGLGAGILDTGANTFVGALFEESSATR-LNVLHGFFGLGALIGPLIATSLLTSEL---SWSWAYLIIGLIYLLLAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 180 AWLIFykhprdqkKLSDEERDYIINGQESQHQTDNGKKmsvwqiLGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYG 259
Cdd:cd17333 166 LILLT--------LFPELPSARNPQQSVGAFSASASRL------LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 260 FNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAH 339
Cdd:cd17333 232 VSDGLAGYLLSGFWVGITIGRLLGGPI---------SRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384840 340 QSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALvVGALADTIGfspLFAVLAIFDLMGAVVI 408
Cdd:cd17333 303 AALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFI-MGFIAEAVG---IQTAMLLITILYAIIF 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
237-409 |
3.04e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 45.87 E-value: 3.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 237 FLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFAWMPMLFADLGCIVGGYLpplfqrwfgVNLIVSRKMVVTMGALLMIGP 316
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRL---------SDRFGRRRVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 317 GMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAV 396
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170
....*....|...
gi 505384840 397 LAIFDLMGAVVIW 409
Cdd:pfam07690 157 LAILSLLAAVLLL 169
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
29-176 |
4.82e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 45.26 E-value: 4.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAV 108
Cdd:cd17504 15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ 94
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 505384840 109 GAAeAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFA 176
Cdd:cd17504 95 GIG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL 161
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
30-204 |
4.87e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 45.70 E-value: 4.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 30 AAAAPTLMEELHISTQqYSYIIAAYSAAYTVMQPVAGYVLDILGTK---IGYAFFAVAWAVFCGAtalAGSWGGLALARG 106
Cdd:cd06179 18 AAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRwffIGGNLLGVVGSIVAGT---AKSVNMLIGGQA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 107 AVGAAeAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPpLVVWAIVMH---SWQMAFIISGVLSFAWAMAWLI 183
Cdd:cd06179 94 LIGIG-AGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGP-LIAGALVEAnaaGWRWIFYINAIFNALALILLFF 171
|
170 180
....*....|....*....|.
gi 505384840 184 FYKHPRDQKKLSDEERDYIIN 204
Cdd:cd06179 172 FYHPPPRPQLHGSSTRQKLKR 192
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
29-189 |
4.96e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 45.33 E-value: 4.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 29 VAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAV 108
Cdd:cd17476 17 VIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQ 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 109 GAAEAAMIPAGLKASSEWF-PAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAMAwLIFYKH 187
Cdd:cd17476 97 GLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVA-AIFWTS 175
|
..
gi 505384840 188 PR 189
Cdd:cd17476 176 PS 177
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
37-183 |
8.02e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 8.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 37 MEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----IGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAE 112
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKklliLGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505384840 113 AAMipagLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAwAMAWLI 183
Cdd:cd17370 306 SIE----RAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALI-ALLLLL 371
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
35-271 |
1.59e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 43.44 E-value: 1.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 35 TLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAG-SWGGLALARGAVGAAEA 113
Cdd:TIGR00886 27 LIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVqSYSVLLLIRLFIGIAGG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 114 AMIPAgLKASSEWFPAKER----SIAVGYFNVGSSIGAMIAPPLVVWAI------VMHSWQMAFIIsGVLSFAWAMAWLI 183
Cdd:TIGR00886 107 SFASC-MPWISFFFPKKIQgtalGLAAGWGNMGGGVAQFVMPPIIGSLIfgggqpAHLAWGWAFVI-VPAGILLLPALLI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 184 FY---KHPRDQKKlsdeerdyiingqesqhqTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGF 260
Cdd:TIGR00886 185 FFvgaDTPPGKPA------------------TGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGL 246
|
250
....*....|.
gi 505384840 261 NLKEIAMFAWM 271
Cdd:TIGR00886 247 SKVQAGAYASL 257
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-387 |
2.57e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.95 E-value: 2.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 12 IALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTK----IGYAFFAVAwAV 87
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRpvllAGLLLFILA-SL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCgatALAGSWGGLALAR---GAVGAAEAAMIPAGLKASsewFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQ 164
Cdd:cd17320 80 LC---ALASSIEQLLIARflqGLGAAAGSVVARAIVRDL---YSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 165 MAFI---ISGVLSFAWAMAWLifyKHPRDQKKLSDEERDYIINGQEsqhqtdngkkmsvwqILGTRQFWGIALPRFLAEP 241
Cdd:cd17320 154 AIFVflaLLGLLLLLLVLLFL---PETLPEEKRKPLLSSLLRAYKR---------------VLKNRRFLGYALALGLSFA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 242 AWGTFNAWIPLFMFKVYGFNlkeIAMFAWMpMLFADLGCIVGGYLPPLFQRWFGVNLIVSRKMVVTMGALLMIGPGMIGL 321
Cdd:cd17320 216 GLFAYLAAAPFIYIEQLGLS---PAQFGLL-FALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLG 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505384840 322 FTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRnEVATANGLTGMAAWTASTLFALVVGALADT 387
Cdd:cd17320 292 GLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPH-VAGTASALLGFLQFLIGALAGALVGLLPNG 356
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
34-411 |
3.07e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.59 E-value: 3.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARgAVGAAEA 113
Cdd:cd17331 24 PYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 114 AMiPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFA-WAMAWLIfykhPRDQK 192
Cdd:cd17331 103 AM-QAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLsIVLVILL----IPSNT 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 193 KLSDEERDyiiNGQESQHQTDNGKKMSVwqILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVYGFNLKEIAMFawMP 272
Cdd:cd17331 178 KSKREKEA---KESASPPSVFNLKEILR--LLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYL--MS 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 273 MLFAdLGCIVGGYLPPLFQRWFGvnlivSRKMVVTMGALLMIG-PGMIGLFTSP--YVAIALLCIGGFAHQSLSGALITL 349
Cdd:cd17331 251 YAGV-LGMVVQGLLVGPLTKRFG-----ERSLLKLSVALLAIGyLLLAFVTTVWqlLVLLLPLVIGGSVLYTVITSLLTK 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505384840 350 SSDvfgRNEVATANGLTgMAAWTASTLFA-LVVGALADTIGFsPLFAVLAIFDLMGAVVIWTV 411
Cdd:cd17331 325 AVP---PEDTGTALGLS-HALFSLVRTVSpTIGGALLQAYGF-PSFGLLGAAINGLLTVYLLL 382
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-400 |
3.89e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.55 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEA 113
Cdd:cd17477 20 SLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMhSWQMAFIISGVLSFAWAMAWLIFYKHPRdqkk 193
Cdd:cd17477 100 GLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GALPFLIAAVLLLLALVPLLLTRRAAPE---- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 194 lsdeerdyiingqesqhqTDNGKKMSVWQILgtRQFWGIALPRFLAEPAWGTFNAWIPLFMFKVyGFNLKEIAMFAWMPM 273
Cdd:cd17477 175 ------------------IEEAESISLRRLL--RIAPLALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 274 LFADLGCIVGGYLPPLFQRwfgvnlivSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDV 353
Cdd:cd17477 234 LGGLLLQWPLGWLADRFDR--------RRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDR 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 505384840 354 FGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSPLFAVLAIF 400
Cdd:cd17477 306 LPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAV 352
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
36-175 |
4.02e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.15 E-value: 4.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 36 LMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEAAM 115
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGVLGGLGLGL 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505384840 116 I-PAGLKASSEWFpAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSF 175
Cdd:cd17352 109 IySPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCL 168
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
8-407 |
4.30e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 42.40 E-value: 4.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAV 87
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 88 FCGATALAGSWGGLALARGA-VGAAEAAMIPAGLKASSEWFPAKeRSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMA 166
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVfIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 167 FIISGVLsfAWAMAWLIFYKHPRDQKKLSDEErdyiingqesqhQTDNGKKMSVWQILGTRQFWGIALPRFLaepawgTF 246
Cdd:cd17314 160 YTILGIL--AAIVLSVVSLLGFKEPPDNQARL------------HVQKKKTQTMGEIFRDKVFWILFIAIFL------VL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 247 NAWIPLFMFKV-YGFNLKEIAMFAWMPML-FADLGCIVGGYLPPLFQRWFGVNLivsRKMVVTMG-ALLMIGPGMIGLFT 323
Cdd:cd17314 220 IGGFLFIANMAsLVRSLQLDAPSFVTKLMsIYGLFNAFGRLLWGIVADFFGGRL---STLSILLTiLGLGLCAFLFLLKM 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 324 SPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVVGALAD-TIGFSPLFAVLAIFDL 402
Cdd:cd17314 297 TPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDrTPSYISAVYIYAVIVF 376
|
....*
gi 505384840 403 MGAVV 407
Cdd:cd17314 377 LASAI 381
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
34-183 |
6.53e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.77 E-value: 6.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFA--VAWAVFCGATALAGSWGGLALARGAVGAA 111
Cdd:cd17352 207 PSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFtlLILGLSLLAFPLATTYVGLIVFSVLFGFC 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 505384840 112 EAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVM-HSWQMAFIISGVLSFAWAMAWLI 183
Cdd:cd17352 287 SGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYtGDYDAAFYFCGACLLLSGVLLFL 359
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
127-409 |
9.63e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 41.06 E-value: 9.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 127 FPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIisgVLSFAWAMAWLIFYKHPRDQKKlsdeerdyiinGQ 206
Cdd:cd17485 121 LTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLL---SLAALYLLLLLPVLFLRELELP-----------QQ 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 207 ESQHQTDNGKKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFMFKvYGFNLKEIAM-FAWMPMLFADLGCIVGGY 285
Cdd:cd17485 187 PPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVD-RGFSLSQIGLlSGVGGSLVSIAGSLLGGY 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 286 LpplFQRWFGVNLIVSRKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVAT---- 361
Cdd:cd17485 266 L---LKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGMITTALFTLMMDCSQQAQAGTdytl 342
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 505384840 362 ---ANGLTGMaawtastLFALVVGALADTIGFSPLFAVLAIFDLMGAVVIW 409
Cdd:cd17485 343 latVEVLGKL-------LFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
91-182 |
1.16e-03 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 40.79 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 91 ATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIIS 170
Cdd:cd17382 97 PIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVY 176
|
90
....*....|..
gi 505384840 171 GVLSFAWAMAWL 182
Cdd:cd17382 177 GVFGIIWYMFWM 188
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
302-413 |
1.33e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 40.64 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 302 RKMVVTMGALLMIGPGMIGLFTSPYVAIALLCIGGFAHQSLSGALITLSSDVFGRNEVATANGLTGMAAWTASTLFALVV 381
Cdd:cd17325 61 KRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG 140
|
90 100 110
....*....|....*....|....*....|..
gi 505384840 382 GALADTIGFSPLFAVLAIFDLMGAVVIWTVLK 413
Cdd:cd17325 141 GLLADALGYRAPFLVCAALALLALVLALLLLP 172
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-151 |
1.92e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 9 WYMIALVTLGTVLGYLTrntvaAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVF 88
Cdd:pfam07690 204 WLLLALLLFGFAFFGLL-----TYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505384840 89 CGATALAGSWGGLALARGA---VGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAP 151
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLAlllLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
34-181 |
3.13e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 3.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAV-GAAE 112
Cdd:cd17477 212 PLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLwGGAA 291
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505384840 113 AAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGVLSFAWAMAW 181
Cdd:cd17477 292 GPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
130-392 |
3.30e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 39.51 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 130 KERSIAVGYFNVGSSIGAMI----APPLVVWA---IVMHSWQMAFIISGVLSFAWAmawLIFYKHPRdqkklsdeERDYI 202
Cdd:cd17332 132 EERTSLTSWRMFFATIGGLLvtvlPPPLVAYFgggNASRGYFLTALIIGIIGIILL---LICFFGTR--------ERVVP 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 203 INGQESQHQTdngkKMSVWQILGTRQFWGIALPRFLAEPAWGTFNAWIPLFmfkvYGFNLKEIAMFAWMPMLFAdLGCIV 282
Cdd:cd17332 201 PEEEKSKLPL----LKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYY----FKYVLGGRAELVLLLLLIL-SGALL 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 283 GGYLPPLFQRWFGvnlivsRKMVVTMGALLMIgPGMIGLFTSPY----VAIALLCIGGFAHQSLSGALITLSSDV----- 353
Cdd:cd17332 272 ALLPWPPLKKRFG------KKKAFFIGLLLAI-LGLLLLFFLPPgnlvLILVLAVLAGIGYGGANLLPWAMLADVidyge 344
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 505384840 354 --FGRNEVATANGLTGMAAWTASTLFALVVGALADTIGFSP 392
Cdd:cd17332 345 lkTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVA 385
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
63-189 |
4.00e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 39.23 E-value: 4.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 63 PVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVG 142
Cdd:TIGR00898 145 FVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVF 224
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 505384840 143 SSIGAMIApPLVVWAIvmHSWQMAFIISGVLSFAWAMAWLIFYKHPR 189
Cdd:TIGR00898 225 FSLGLVLL-PLVAYFI--PDWRWLQLAVSLPTFLFFLLSWFVPESPR 268
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
34-191 |
4.14e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.21 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 34 PTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAVGAAEA 113
Cdd:cd06180 23 PLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 114 AMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH-SWQMAFIISGVLSFAWA-MAWLIFYKHPRDQ 191
Cdd:cd06180 103 FVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGlSWRAGWLALALLSAVLLlLSFLLLRRGPSAP 182
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
32-169 |
4.74e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 39.33 E-value: 4.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 32 AAPTLMEELHISTQQYSYIIAAYSaayTVMqpvAGYVLDI--LGTKIGYAFFAVAWAVFCG----ATALAGSWGGLALAR 105
Cdd:PRK14995 28 AAPTLSMTLGASGNELLWIIDIYS---LVM---AGMVLPMgaLGDRIGFKRLLMLGGTLFGlaslAAAFSPTASWLIATR 101
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505384840 106 GAVGAAEAAMIPAGLKASSEWF-PAKERSIAVGYFNVGSSIGAMIApPLVVWAIVMH-SWQMAFII 169
Cdd:PRK14995 102 ALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFG-PLVGGILLEHfYWGSVFLI 166
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
8-155 |
7.07e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 38.54 E-value: 7.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 8 RWYMIALVTLGTVLGYLTRNTVAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGY---AFFAVA 84
Cdd:cd17334 2 RWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVligAALNAL 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505384840 85 WAVF-CGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIG---AMIAPPLVV 155
Cdd:cd17334 82 GSVLkCIPLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGcaiGFLLPPVVV 156
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
32-197 |
7.21e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.40 E-value: 7.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 32 AAPTLMEELHISTQQYSYiiaAYSAAYTVMQPVA---GYVLDILGTKIGYAFFAVAWAVFCGATALAGSWGGLALARGAV 108
Cdd:PRK11551 37 AAPRMAQEFGLDVAQMGW---AFSAGILGLLPGAllgGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 109 GAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMHSWQMAFIISGV---LSFAWAMAWLIFY 185
Cdd:PRK11551 114 GVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVgplLLVPLLMRWLPES 193
|
170
....*....|..
gi 505384840 186 KHPRDQKKLSDE 197
Cdd:PRK11551 194 RAFAQAAGAGKQ 205
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-184 |
8.49e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.37 E-value: 8.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 2 RKIKGLRWYMIALVTLGTVLGYLTrntvAAAAPTLMEELHISTQQYSYIIAAYSAAYTVMQPVAGYVLDILGTKIGYAFF 81
Cdd:cd06173 205 RRSPLLRLLLLALALFALLGGALT----VLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505384840 82 AVAWAVFCGATALAGSWGGLALARGAVGAAEAAMIPAGLKASSEWFPAKERSIAVGYFNVGSSIGAMIAPPLVVWAIVMH 161
Cdd:cd06173 281 ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
170 180
....*....|....*....|...
gi 505384840 162 SWQMAFIISGVLSFAWAMAWLIF 184
Cdd:cd06173 361 GLSAVFLLAGALLLLAALLLLLL 383
|
|
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