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Conserved domains on  [gi|505402481|ref|WP_015589583|]
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MULTISPECIES: amino acid permease [Salmonella]

Protein Classification

amino acid permease( domain architecture ID 11435282)

amino acid permease similar to Schizosaccharomyces pombe vacuolar amino acid transporter 5 that is involved in the vacuolar uptake of histidine, glutamate, tyrosine, arginine, lysine, and serine, and required for sporulation

Gene Ontology:  GO:0006865

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
SdaC COG0814
Amino acid permease [Amino acid transport and metabolism];
1-409 1.44e-90

Amino acid permease [Amino acid transport and metabolism];


:

Pssm-ID: 440576  Cd Length: 401  Bit Score: 278.95  E-value: 1.44e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   1 MSKIWSKDETLWSFALYGTAVGAGTLFLPIRLGSAGAIVLFITALVAWPLTYWPHKALCQFILSSKtsAGEGITGAVTHY 80
Cdd:COG0814    4 KAMKWRKSDLGWVLLIAGTAIGAGMLALPIAAGGGGFWPSLLLLLLAWPLMYLSHLLLLEVNLSSP--PGADITTVVEEY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481  81 YGKKIGNIITTLYFIAFFVVVLIYAVAITNSLTEQLAKHIQIDIrIRMAVSFGVVLILNMIFLMGRHATLRVMGFLVFPL 160
Cdd:COG0814   82 LGKGGGILIGLLYFFLLYPLLLAYISGGGNILASFLVNQLGLTI-PRWLLSLIFILVLGAIVWLGTRLVDRVNRILVFPK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 161 IAYFLFLSLYLTGSWQPSLLTGqmSLDSHTLHQVWISIPVMVFAFSHTPIISTFAIDRRENfgdqaMDKCKKIMKVAYLI 240
Cdd:COG0814  161 IIAFLLLSLYLIPHWNLANLLN--SALPSYLKYLWLALPVLLTSFGFHPIIPSLVKYYRKD-----AKKLRRAILIGSLI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 241 ICLSVLFFVFSCLLSIPPSYIEDARNEGVTILSALSMMPNAPaWLSISGIIVAVVAMSKSFLGTYFGVIEGATEMVRttl 320
Cdd:COG0814  234 PLVIYLFWVFSCLGSLPPEEFAEAKAQNISLLSALANVFNSP-LISYLGPLFAFFAIATSFLGVYLGLFDFLADLFK--- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 321 qqvgvKKSRAFNRALSIMLVSGITFIICCINPNAISMIYAISGPLIAMILFIMPTLSTYLIPALKP--YRSVG----NFI 394
Cdd:COG0814  310 -----KKKSKKGRLKTALLTFLPPWIVALLNPSIFILALGYAGPIIAILLFILPALLVWKVRARFPlkYRVPGgklsLIF 384

                        410
                 ....*....|....*
gi 505402481 395 TLVVGLLCVSVMFFG 409
Cdd:COG0814  385 VILFGLLAISAQILS 399
 
Name Accession Description Interval E-value
SdaC COG0814
Amino acid permease [Amino acid transport and metabolism];
1-409 1.44e-90

Amino acid permease [Amino acid transport and metabolism];


Pssm-ID: 440576  Cd Length: 401  Bit Score: 278.95  E-value: 1.44e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   1 MSKIWSKDETLWSFALYGTAVGAGTLFLPIRLGSAGAIVLFITALVAWPLTYWPHKALCQFILSSKtsAGEGITGAVTHY 80
Cdd:COG0814    4 KAMKWRKSDLGWVLLIAGTAIGAGMLALPIAAGGGGFWPSLLLLLLAWPLMYLSHLLLLEVNLSSP--PGADITTVVEEY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481  81 YGKKIGNIITTLYFIAFFVVVLIYAVAITNSLTEQLAKHIQIDIrIRMAVSFGVVLILNMIFLMGRHATLRVMGFLVFPL 160
Cdd:COG0814   82 LGKGGGILIGLLYFFLLYPLLLAYISGGGNILASFLVNQLGLTI-PRWLLSLIFILVLGAIVWLGTRLVDRVNRILVFPK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 161 IAYFLFLSLYLTGSWQPSLLTGqmSLDSHTLHQVWISIPVMVFAFSHTPIISTFAIDRRENfgdqaMDKCKKIMKVAYLI 240
Cdd:COG0814  161 IIAFLLLSLYLIPHWNLANLLN--SALPSYLKYLWLALPVLLTSFGFHPIIPSLVKYYRKD-----AKKLRRAILIGSLI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 241 ICLSVLFFVFSCLLSIPPSYIEDARNEGVTILSALSMMPNAPaWLSISGIIVAVVAMSKSFLGTYFGVIEGATEMVRttl 320
Cdd:COG0814  234 PLVIYLFWVFSCLGSLPPEEFAEAKAQNISLLSALANVFNSP-LISYLGPLFAFFAIATSFLGVYLGLFDFLADLFK--- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 321 qqvgvKKSRAFNRALSIMLVSGITFIICCINPNAISMIYAISGPLIAMILFIMPTLSTYLIPALKP--YRSVG----NFI 394
Cdd:COG0814  310 -----KKKSKKGRLKTALLTFLPPWIVALLNPSIFILALGYAGPIIAILLFILPALLVWKVRARFPlkYRVPGgklsLIF 384

                        410
                 ....*....|....*
gi 505402481 395 TLVVGLLCVSVMFFG 409
Cdd:COG0814  385 VILFGLLAISAQILS 399
PRK13629 PRK13629
threonine/serine transporter TdcC; Provisional
 5-403 1.15e-61

threonine/serine transporter TdcC; Provisional


Pssm-ID: 184191  Cd Length: 443  Bit Score: 205.47  E-value: 1.15e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   5 WSKDETLWSFALYGTAVGAGTLFLPIRLGSAGAIVLFITALVAWPLTYWPHKALCQFILSSKTSAGEgITGAVTHYYGKK 84
Cdd:PRK13629  17 WRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGN-ITETVEEHFGKT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481  85 IGNIITTLYFIAFFVVVLIYAVAITNSLTEQLAKHIQIDIRIRMAVSFGVVLILNMIFLMGRHATLRVMGFLVFPLIAYF 164
Cdd:PRK13629  96 GGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 165 LFLSLYLTGSWQPSLLT----GQMSLDSH--TLHQVWISIPVMVFAFSHTPIISTFAIDRRE----NFG-DQAMDKCKKI 233
Cdd:PRK13629 176 VLISLSLIPYWNSAVIDqvdlGSLSLTGHdgILVTVWLGISIMVFSFNFSPIVSSFVVSKREeyekDFGrDFTERKCSQI 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 234 MKVAYLIICLSVLFFVFSCLLSIPPSYIEDARNEGVTILSAL-----SMMPNAPAW---LSISGIIVAVVAMSKSFLGTY 305
Cdd:PRK13629 256 ISRASMLMVAVVMFFAFSCLFTLSPQNMAEAKAQNIPVLSYLanhfaSMTGTKSTFaitLEYAASIIALVAIFKSFFGHY 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 306 FGVIEGATEMV-----RTTLQQVGVKKSrafnRALSIMLVSGITFIICCINPNAISMIYAISGPLIAMILFIMPTLSTYL 380
Cdd:PRK13629 336 LGTLEGLNGLIlkfgyKGDKTKVSLGKL----NTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRK 411

                        410       420
                 ....*....|....*....|....
gi 505402481 381 IPALKPYRS-VGNFITLVVGLLCV 403
Cdd:PRK13629 412 APSLAKYRGrLDNVFVTVIGLLTI 435
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
 13-253 1.50e-03

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 40.37  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   13 SFALYGTAVGAGTLFLPIRLGSAGAIVLFITALVAWPLTYWPHKALCQFILSSKTSAGEGIT--GAVTHYYGKKIGNIIT 90
Cdd:pfam01490   9 VFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVTGKRNKSygDLGYRLLGPKGRLLIL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   91 TLYFIAFFVVVLIYAVAITNSL---TEQLAKHIQIDIRIRMAVSFGVVLILNMIFLMgrhATLRVMGFLVFPLIAYFLFL 167
Cdd:pfam01490  89 FAILLNLFGVCISYLIFAGDNLpaiFDSFFDTCPISLVYFIIIFGLIFIPLSFIPNL---SALSILSLLAAVSSLYYIVI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481  168 SLYLTGSWQPSLLTGQMSLDSHTLHQVW---ISIPVMVFAFSHTPIISTFAIDRRENfgdQAMDKCKKIMKVAYLIICls 244
Cdd:pfam01490 166 LVLSVAEGIVLTAQGVGHLGSKTNIKLAgtfLAIGIIVFAFEGHAVLLPIQNEMKNP---SKFKAMTKILLTAIIIAT-- 240


                  ....*....
gi 505402481  245 VLFFVFSCL 253
Cdd:pfam01490 241 VLYILIGLV 249
 
Name Accession Description Interval E-value
SdaC COG0814
Amino acid permease [Amino acid transport and metabolism];
1-409 1.44e-90

Amino acid permease [Amino acid transport and metabolism];


Pssm-ID: 440576  Cd Length: 401  Bit Score: 278.95  E-value: 1.44e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   1 MSKIWSKDETLWSFALYGTAVGAGTLFLPIRLGSAGAIVLFITALVAWPLTYWPHKALCQFILSSKtsAGEGITGAVTHY 80
Cdd:COG0814    4 KAMKWRKSDLGWVLLIAGTAIGAGMLALPIAAGGGGFWPSLLLLLLAWPLMYLSHLLLLEVNLSSP--PGADITTVVEEY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481  81 YGKKIGNIITTLYFIAFFVVVLIYAVAITNSLTEQLAKHIQIDIrIRMAVSFGVVLILNMIFLMGRHATLRVMGFLVFPL 160
Cdd:COG0814   82 LGKGGGILIGLLYFFLLYPLLLAYISGGGNILASFLVNQLGLTI-PRWLLSLIFILVLGAIVWLGTRLVDRVNRILVFPK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 161 IAYFLFLSLYLTGSWQPSLLTGqmSLDSHTLHQVWISIPVMVFAFSHTPIISTFAIDRRENfgdqaMDKCKKIMKVAYLI 240
Cdd:COG0814  161 IIAFLLLSLYLIPHWNLANLLN--SALPSYLKYLWLALPVLLTSFGFHPIIPSLVKYYRKD-----AKKLRRAILIGSLI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 241 ICLSVLFFVFSCLLSIPPSYIEDARNEGVTILSALSMMPNAPaWLSISGIIVAVVAMSKSFLGTYFGVIEGATEMVRttl 320
Cdd:COG0814  234 PLVIYLFWVFSCLGSLPPEEFAEAKAQNISLLSALANVFNSP-LISYLGPLFAFFAIATSFLGVYLGLFDFLADLFK--- 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 321 qqvgvKKSRAFNRALSIMLVSGITFIICCINPNAISMIYAISGPLIAMILFIMPTLSTYLIPALKP--YRSVG----NFI 394
Cdd:COG0814  310 -----KKKSKKGRLKTALLTFLPPWIVALLNPSIFILALGYAGPIIAILLFILPALLVWKVRARFPlkYRVPGgklsLIF 384

                        410
                 ....*....|....*
gi 505402481 395 TLVVGLLCVSVMFFG 409
Cdd:COG0814  385 VILFGLLAISAQILS 399
PRK13629 PRK13629
threonine/serine transporter TdcC; Provisional
 5-403 1.15e-61

threonine/serine transporter TdcC; Provisional


Pssm-ID: 184191  Cd Length: 443  Bit Score: 205.47  E-value: 1.15e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   5 WSKDETLWSFALYGTAVGAGTLFLPIRLGSAGAIVLFITALVAWPLTYWPHKALCQFILSSKTSAGEgITGAVTHYYGKK 84
Cdd:PRK13629  17 WRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALARLCLSGSNPSGN-ITETVEEHFGKT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481  85 IGNIITTLYFIAFFVVVLIYAVAITNSLTEQLAKHIQIDIRIRMAVSFGVVLILNMIFLMGRHATLRVMGFLVFPLIAYF 164
Cdd:PRK13629  96 GGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLGFAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 165 LFLSLYLTGSWQPSLLT----GQMSLDSH--TLHQVWISIPVMVFAFSHTPIISTFAIDRRE----NFG-DQAMDKCKKI 233
Cdd:PRK13629 176 VLISLSLIPYWNSAVIDqvdlGSLSLTGHdgILVTVWLGISIMVFSFNFSPIVSSFVVSKREeyekDFGrDFTERKCSQI 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 234 MKVAYLIICLSVLFFVFSCLLSIPPSYIEDARNEGVTILSAL-----SMMPNAPAW---LSISGIIVAVVAMSKSFLGTY 305
Cdd:PRK13629 256 ISRASMLMVAVVMFFAFSCLFTLSPQNMAEAKAQNIPVLSYLanhfaSMTGTKSTFaitLEYAASIIALVAIFKSFFGHY 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481 306 FGVIEGATEMV-----RTTLQQVGVKKSrafnRALSIMLVSGITFIICCINPNAISMIYAISGPLIAMILFIMPTLSTYL 380
Cdd:PRK13629 336 LGTLEGLNGLIlkfgyKGDKTKVSLGKL----NTISMIFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRK 411

                        410       420
                 ....*....|....*....|....
gi 505402481 381 IPALKPYRS-VGNFITLVVGLLCV 403
Cdd:PRK13629 412 APSLAKYRGrLDNVFVTVIGLLTI 435
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
 13-253 1.50e-03

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 40.37  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   13 SFALYGTAVGAGTLFLPIRLGSAGAIVLFITALVAWPLTYWPHKALCQFILSSKTSAGEGIT--GAVTHYYGKKIGNIIT 90
Cdd:pfam01490   9 VFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCSKEVPVTGKRNKSygDLGYRLLGPKGRLLIL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   91 TLYFIAFFVVVLIYAVAITNSL---TEQLAKHIQIDIRIRMAVSFGVVLILNMIFLMgrhATLRVMGFLVFPLIAYFLFL 167
Cdd:pfam01490  89 FAILLNLFGVCISYLIFAGDNLpaiFDSFFDTCPISLVYFIIIFGLIFIPLSFIPNL---SALSILSLLAAVSSLYYIVI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481  168 SLYLTGSWQPSLLTGQMSLDSHTLHQVW---ISIPVMVFAFSHTPIISTFAIDRRENfgdQAMDKCKKIMKVAYLIICls 244
Cdd:pfam01490 166 LVLSVAEGIVLTAQGVGHLGSKTNIKLAgtfLAIGIIVFAFEGHAVLLPIQNEMKNP---SKFKAMTKILLTAIIIAT-- 240


                  ....*....
gi 505402481  245 VLFFVFSCL 253
Cdd:pfam01490 241 VLYILIGLV 249
Trp_Tyr_perm pfam03222
Tryptophan/tyrosine permease family;
18-310 2.13e-03

Tryptophan/tyrosine permease family;


Pssm-ID: 367404  Cd Length: 393  Bit Score: 39.96  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   18 GTAVGAGTLFLPIRLGSAGAIVLFITALVAWPLTYwpHKALCQFILSSKTSAGEGITGAVTHYYGKKIGNIITTLYFIAF 97
Cdd:pfam03222  14 GTAIGAGMLALPVATAGAGFIPSLLLLILSWFLML--ASGLLLLEVYLWYPEGASFNTLAKDLLGKKGNIIAGLVYAFLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481   98 FVVVLIYAVAITNSLTEQLAKHIQIDIrIRMAVSFGVVLILNMIFLMGRHATLRVMGFLVFPLIAYFLFLSLYLTGSWQP 177
Cdd:pfam03222  92 YILTYAYISGGGSILSRVIPEMFGIPW-SARAAPLIFTLLFGPFVWAGTKAVDRINRVLIFGKIIAFALVFSGLLPKIKG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505402481  178 SLLTGqmSLDSHTLHQVWISIPVMVFAFSHTPIISTFAidrreNFGDQAMDKCKKIMKVAYLIICLSVLFFVFSCLLSIP 257
Cdd:pfam03222 171 DLLLD--ALDTSYWPYILMALPVFFTSFGFHGNVPSLY-----KYYGGNVKKVRKAILIGTAIPLVLYILWQLATLGNLP 243

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 505402481  258 PSYIEDARNEGV---TILSALSMMPNAPAwLSISGIIVAVVAMSKSFLGTYFGVIE 310
Cdd:pfam03222 244 REEFAPIIAKGGnldTLVEALLGVLKSPS-FELALELFSFFALATSFLGVALGLFD 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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