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Conserved domains on  [gi|505445363|ref|WP_015632465|]
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MULTISPECIES: type II toxin-antitoxin system antitoxin CcdA [Enterobacterales]

Protein Classification

type II toxin-antitoxin system antitoxin CcdA( domain architecture ID 10014361)

type II toxin-antitoxin (TA) system antitoxin CcdA is the antitoxin component of the TA system that inhibits the post-segregational killing of plasmid-free cells; binds to and blocks the activity of the toxin CcdB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13710 PRK13710
type II toxin-antitoxin system antitoxin CcdA;
1-72 1.53e-35

type II toxin-antitoxin system antitoxin CcdA;


:

Pssm-ID: 184266  Cd Length: 72  Bit Score: 114.60  E-value: 1.53e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505445363  1 MKHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW 72
Cdd:PRK13710  1 MKQRITVTVDSDSYQLLKAADVNISGLVNTAMQNEARRLRAERWKAENREGMAEVARFIEMNGSFADENRNW 72
 
Name Accession Description Interval E-value
PRK13710 PRK13710
type II toxin-antitoxin system antitoxin CcdA;
1-72 1.53e-35

type II toxin-antitoxin system antitoxin CcdA;


Pssm-ID: 184266  Cd Length: 72  Bit Score: 114.60  E-value: 1.53e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505445363  1 MKHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW 72
Cdd:PRK13710  1 MKQRITVTVDSDSYQLLKAADVNISGLVNTAMQNEARRLRAERWKAENREGMAEVARFIEMNGSFADENRNW 72
CcdA pfam07362
Post-segregation antitoxin CcdA; This family consists of several Enterobacterial ...
 2-72 2.00e-24

Post-segregation antitoxin CcdA; This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein.


Pssm-ID: 429428  Cd Length: 71  Bit Score: 86.11  E-value: 2.00e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505445363   2 KHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW 72
Cdd:pfam07362  1 KKATNLSLNADLLAEARALGINLSATLEEALAEEVRRRKAERWKEENREAIEAYNRFIEKHGLFADEYRSF 71
COG5302 COG5302
Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: ...
 2-72 6.78e-22

Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: prophages, transposons];


Pssm-ID: 444102  Cd Length: 80  Bit Score: 80.32  E-value: 6.78e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505445363  2 KHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW 72
Cdd:COG5302  10 KKATNVSLDADLLAEARALGINLSAALEEALAEAVREAKAERWLEENAEAIEAYNRFVEEHGLPLDEYRSF 80
 
Name Accession Description Interval E-value
PRK13710 PRK13710
type II toxin-antitoxin system antitoxin CcdA;
1-72 1.53e-35

type II toxin-antitoxin system antitoxin CcdA;


Pssm-ID: 184266  Cd Length: 72  Bit Score: 114.60  E-value: 1.53e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505445363  1 MKHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW 72
Cdd:PRK13710  1 MKQRITVTVDSDSYQLLKAADVNISGLVNTAMQNEARRLRAERWKAENREGMAEVARFIEMNGSFADENRNW 72
CcdA pfam07362
Post-segregation antitoxin CcdA; This family consists of several Enterobacterial ...
 2-72 2.00e-24

Post-segregation antitoxin CcdA; This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein.


Pssm-ID: 429428  Cd Length: 71  Bit Score: 86.11  E-value: 2.00e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505445363   2 KHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW 72
Cdd:pfam07362  1 KKATNLSLNADLLAEARALGINLSATLEEALAEEVRRRKAERWKEENREAIEAYNRFIEKHGLFADEYRSF 71
COG5302 COG5302
Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: ...
 2-72 6.78e-22

Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: prophages, transposons];


Pssm-ID: 444102  Cd Length: 80  Bit Score: 80.32  E-value: 6.78e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505445363  2 KHRASVTVDKEHYLELLAAGVNISGLVNEAIGREARRIQAERWKAENREGMEEVANFIAQHGSFADENRSW 72
Cdd:COG5302  10 KKATNVSLDADLLAEARALGINLSAALEEALAEAVREAKAERWLEENAEAIEAYNRFVEEHGLPLDEYRSF 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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