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Conserved domains on  [gi|505448635|ref|WP_015635737|]
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MULTISPECIES: ABC transporter permease [Pseudomonas]

Protein Classification

ABC transporter permease( domain architecture ID 11427288)

ABC transporter permease is the transmembrane subunit (TM) found in periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporters which generally bind type 2 PBPs

Gene Ontology:  GO:0022857|GO:0005524
PubMed:  35642569

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
18-233 1.84e-45

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 152.61  E-value: 1.84e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  18 IGGWEYLSRQDAAGAYAFVPLSTIASALLELLGNGELPVNLLASLGRASGGLLLGTLAGVMLGALMALSTLANRLIGPLF 97
Cdd:COG0600   23 LALWELAARLGLVPPFLLPSPSAVLAALVELLASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  98 HSIRQVPMLGWIPLIAMWFGNGEFSKMLIVSLAAFYPMVLNTYQGFCQVERRYREVGQVLVLNPAQRLRHILLPAALPSI 177
Cdd:COG0600  103 VFLRPIPPLALAPLLILWFGIGEASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYI 182
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505448635 178 ATGLLQALAFAWVTAVGSElFLSSGAGLGNLMMNAEAGSRMEVIVLCVLCIGLCGY 233
Cdd:COG0600  183 FTGLRIALGLAWIGLVVAE-LLGASSGLGYLILDARQLLDTDLVFAAILVIGLLGL 237
 
Name Accession Description Interval E-value
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
18-233 1.84e-45

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 152.61  E-value: 1.84e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  18 IGGWEYLSRQDAAGAYAFVPLSTIASALLELLGNGELPVNLLASLGRASGGLLLGTLAGVMLGALMALSTLANRLIGPLF 97
Cdd:COG0600   23 LALWELAARLGLVPPFLLPSPSAVLAALVELLASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  98 HSIRQVPMLGWIPLIAMWFGNGEFSKMLIVSLAAFYPMVLNTYQGFCQVERRYREVGQVLVLNPAQRLRHILLPAALPSI 177
Cdd:COG0600  103 VFLRPIPPLALAPLLILWFGIGEASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYI 182
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505448635 178 ATGLLQALAFAWVTAVGSElFLSSGAGLGNLMMNAEAGSRMEVIVLCVLCIGLCGY 233
Cdd:COG0600  183 FTGLRIALGLAWIGLVVAE-LLGASSGLGYLILDARQLLDTDLVFAAILVIGLLGL 237
ssuC PRK11365
aliphatic sulfonate ABC transporter permease SsuC;
77-232 7.46e-22

aliphatic sulfonate ABC transporter permease SsuC;


Pssm-ID: 183100  Cd Length: 263  Bit Score: 91.15  E-value: 7.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  77 VMLGALMALSTLANRLIGPLFHSIRQVPMLGWIPLIAMWFGNGEFSKMLIVSLAAFYPMVLNTYQGFCQVERRYREVGQV 156
Cdd:PRK11365  81 LILGLISGLSRWGERLLDTSIQMLRNVPHLALIPLVILWFGIDESAKIFLVALGTLFPIYINTWHGIRNIDRGLVEMARS 160
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505448635 157 LVLNPAQRLRHILLPAALPSIATGLLQALAFAWVTAVGSELfLSSGAGLGNLMMNAEAGSRMEVIVLCVLCIGLCG 232
Cdd:PRK11365 161 YGLSGIPLFIHVILPGALPSIMVGVRFALGLMWLTLIVAET-ISANSGIGYLAMNAREFLQTDVVVVAIILYALLG 235
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
77-231 1.14e-10

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 58.85  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635   77 VMLGALMAL--STLANRLIGPLFHSIRQVPMLGWIPLIAM-----WFGNGEFSKMLIVSLAAFYPMVLNTYQGFCQVERR 149
Cdd:pfam00528   2 IPLGIIAALrrGRRLDRLLRPLIDLLQALPSFVLAILLVViailsILGHGILPAIILALLGWAGYARLIRRAALRSLPSD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  150 YREVGQVLVLNPAQRLRHILLPAALPSIATGLLQALAFAWVTAVGSELFLSSGaGLGNLMMNAEAGSRMEVIVLCVLCIG 229
Cdd:pfam00528  82 LVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWP-GLGLLLIEAILGYDYPEIQGPVLAAA 160

                  ..
gi 505448635  230 LC 231
Cdd:pfam00528 161 LI 162
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
77-230 1.14e-06

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 47.66  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  77 VMLGALMALST-LANRLIGPLFHSIRQVPMLGWIPLIAMWFGNGEFSK---------MLIVSLAAFYPMVLNTYQGFCQV 146
Cdd:cd06261   20 LLLGIILARKRgKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGilpglglpaLILALLLIAPFARLIRRAALESI 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635 147 ERRYREVGQVLVLNPAQRLRHILLPAALPSIATGLLQALAFAWVTAVGSELFLSSGAGLGNLMMNAEAGSRMEVIVLCVL 226
Cdd:cd06261  100 PKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLGVAA 179

                 ....
gi 505448635 227 CIGL 230
Cdd:cd06261  180 AVAL 183
 
Name Accession Description Interval E-value
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
18-233 1.84e-45

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 152.61  E-value: 1.84e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  18 IGGWEYLSRQDAAGAYAFVPLSTIASALLELLGNGELPVNLLASLGRASGGLLLGTLAGVMLGALMALSTLANRLIGPLF 97
Cdd:COG0600   23 LALWELAARLGLVPPFLLPSPSAVLAALVELLASGELWEHLLASLLRVLLGFALAALLGVPLGLLLGLSRLLRRLLDPLL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  98 HSIRQVPMLGWIPLIAMWFGNGEFSKMLIVSLAAFYPMVLNTYQGFCQVERRYREVGQVLVLNPAQRLRHILLPAALPSI 177
Cdd:COG0600  103 VFLRPIPPLALAPLLILWFGIGEASKIFVIFLGAFFPILLNTAAGVRSVDPELLELARSLGASRWQILRKVVLPAALPYI 182
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505448635 178 ATGLLQALAFAWVTAVGSElFLSSGAGLGNLMMNAEAGSRMEVIVLCVLCIGLCGY 233
Cdd:COG0600  183 FTGLRIALGLAWIGLVVAE-LLGASSGLGYLILDARQLLDTDLVFAAILVIGLLGL 237
ssuC PRK11365
aliphatic sulfonate ABC transporter permease SsuC;
77-232 7.46e-22

aliphatic sulfonate ABC transporter permease SsuC;


Pssm-ID: 183100  Cd Length: 263  Bit Score: 91.15  E-value: 7.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  77 VMLGALMALSTLANRLIGPLFHSIRQVPMLGWIPLIAMWFGNGEFSKMLIVSLAAFYPMVLNTYQGFCQVERRYREVGQV 156
Cdd:PRK11365  81 LILGLISGLSRWGERLLDTSIQMLRNVPHLALIPLVILWFGIDESAKIFLVALGTLFPIYINTWHGIRNIDRGLVEMARS 160
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505448635 157 LVLNPAQRLRHILLPAALPSIATGLLQALAFAWVTAVGSELfLSSGAGLGNLMMNAEAGSRMEVIVLCVLCIGLCG 232
Cdd:PRK11365 161 YGLSGIPLFIHVILPGALPSIMVGVRFALGLMWLTLIVAET-ISANSGIGYLAMNAREFLQTDVVVVAIILYALLG 235
PRK10160 PRK10160
taurine ABC transporter permease TauC;
58-212 2.17e-18

taurine ABC transporter permease TauC;


Pssm-ID: 182276  Cd Length: 275  Bit Score: 82.14  E-value: 2.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  58 LLASLGRASGGLLLGTLAGVMLGALMALSTLANRLIGPLFHSIRQVPMLGWIPLIAMWFGNGEFSKMLIVSLAAFYPMVL 137
Cdd:PRK10160  80 LAASLTRIVLALLAAVVIGIPVGIAMGLSPTVRGILDPLIELYRPVPPLAYLPLMVIWFGIGETSKILLIYLAIFAPVAM 159
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505448635 138 NTYQGFCQVERRYREVGQVLVLNPAQRLRHILLPAALPSIATGLLQALAFAWVTAVGSELfLSSGAGLGNLMMNA 212
Cdd:PRK10160 160 SALAGVKSAQQVRIRAAQSLGASRAQVLWFVILPGALPEILTGLRIGLGVGWSTLVAAEL-IAATRGLGFMVQSA 233
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
77-231 1.14e-10

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 58.85  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635   77 VMLGALMAL--STLANRLIGPLFHSIRQVPMLGWIPLIAM-----WFGNGEFSKMLIVSLAAFYPMVLNTYQGFCQVERR 149
Cdd:pfam00528   2 IPLGIIAALrrGRRLDRLLRPLIDLLQALPSFVLAILLVViailsILGHGILPAIILALLGWAGYARLIRRAALRSLPSD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  150 YREVGQVLVLNPAQRLRHILLPAALPSIATGLLQALAFAWVTAVGSELFLSSGaGLGNLMMNAEAGSRMEVIVLCVLCIG 229
Cdd:pfam00528  82 LVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWP-GLGLLLIEAILGYDYPEIQGPVLAAA 160

                  ..
gi 505448635  230 LC 231
Cdd:pfam00528 161 LI 162
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
77-230 1.14e-06

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 47.66  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  77 VMLGALMALST-LANRLIGPLFHSIRQVPMLGWIPLIAMWFGNGEFSK---------MLIVSLAAFYPMVLNTYQGFCQV 146
Cdd:cd06261   20 LLLGIILARKRgKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGilpglglpaLILALLLIAPFARLIRRAALESI 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635 147 ERRYREVGQVLVLNPAQRLRHILLPAALPSIATGLLQALAFAWVTAVGSELFLSSGAGLGNLMMNAEAGSRMEVIVLCVL 226
Cdd:cd06261  100 PKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPGTGLLLIFAILFPGDLGVAA 179

                 ....
gi 505448635 227 CIGL 230
Cdd:cd06261  180 AVAL 183
OpuBB COG1174
ABC-type proline/glycine betaine transport system, permease component [Amino acid transport ...
100-230 4.05e-06

ABC-type proline/glycine betaine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440787 [Multi-domain]  Cd Length: 212  Bit Score: 46.20  E-value: 4.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635 100 IRQVPMLGWIPLIAMWFGNGEFSKMLIVSLAAFYPMVLNTYQGFCQVERRYREVGQVLVLNPAQRLRHILLPAALPSIAT 179
Cdd:COG1174   62 LQTIPSLALLALLIPLLGIGPAPAIIALVLYALLPILRNTYTGLRSVDPAVVEAARGMGMTPWQRLWRVELPLALPVILA 141
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 505448635 180 GL----LQALAFAWVTAvgselfLSSGAGLGNLMMNAEAGSRMEVIVL-CVLCIGL 230
Cdd:COG1174  142 GIrtaaVQNIGTATLAA------LIGAGGLGDLIFDGLQLNNTALILAgAILVALL 191
PRK10952 PRK10952
proline/glycine betaine ABC transporter permease ProW;
79-188 2.33e-04

proline/glycine betaine ABC transporter permease ProW;


Pssm-ID: 236805  Cd Length: 355  Bit Score: 41.62  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505448635  79 LGALMALSTLANRLIGPLFHSIRQVPMLGWIPLIAMWFGNGEFSKMLIVSLAAFYPMVLNTYQGFCQVERRYREVGQVLV 158
Cdd:PRK10952 167 LGIWLARSPRAAKIIRPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPPIVRLTILGINQVPADLIEASRSFG 246
                         90       100       110
                 ....*....|....*....|....*....|
gi 505448635 159 LNPAQRLRHILLPAALPSIATGLLQALAFA 188
Cdd:PRK10952 247 ASPRQMLFKVQLPLAMPTIMAGVNQTLMLA 276
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
124-194 5.88e-03

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 37.45  E-value: 5.88e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 505448635 124 MLIVSLAAFYPMVLNTYQ-GFCQVERRYREVGQVLVLNPAQRLRHILLPAALPsiatGLLQALAFAWVTAVG 194
Cdd:COG1178  414 LVLAYVVRFLPFALRSLEaALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRP----GLLAAALLVFVTSMK 481
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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