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Conserved domains on  [gi|505582115|ref|WP_015674803|]
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DUF4867 family protein [Escherichia coli]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4867 super family cl24668
Domain of unknown function (DUF4867); This family consists of uncharacterized proteins around ...
 10-188 4.18e-65

Domain of unknown function (DUF4867); This family consists of uncharacterized proteins around 220 residues in length and is mainly found in various human gut Firmicutes and a few eubacteria species. It is also amply represented in human gut metagenomic datasets. Distant homology analysis and marginal HMM overlaps suggest this family is a distant homolog of Ureidoglycolate hydrolase pfam04115, but this prediction is not verified by experiment, therefore the function of this family is still unknown.


The actual alignment was detected with superfamily member pfam16161:

Pssm-ID: 435181  Cd Length: 199  Bit Score: 199.33  E-value: 4.18e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582115   10 SIHSDEFRPYGNVISAINVDSLLKYLkEEISVPEDqVAYVRSDERLKQYPAVSDIQRQIYGGMPVQAGYVCGVNTTQDGF 89
Cdd:pfam16161   1 SVTDPAFKKYGRVLTGYDFSELLKAM-EKTPLPEG-VIYVPSVPELEALPVAKELQDRVYGGLPIQIGYCNGHNTKLNAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582115   90 EYHQGSEVIIAASDFFLFLGKRELMQGD-TFNGERAEPFFIPAKSVIELYSTTLHYCPMSINAQPFSAAIILLDGTNEDI 168
Cdd:pfam16161  79 EYHRSSEINIAVTDLILLLGKQQDIEEDfTYDTSKVEAFFVPAGTAVEVYATTLHYAPCGVDGKGFKCIVVLPKGTNTPL 158

                         170       180
                  ....*....|....*....|....
gi 505582115  169 DGKNKPT----ILSKRNTWFIAHE 188
Cdd:pfam16161 159 PEPTGKNgedkLLFAKNKWLIAHP 182
 
Name Accession Description Interval E-value
DUF4867 pfam16161
Domain of unknown function (DUF4867); This family consists of uncharacterized proteins around ...
 10-188 4.18e-65

Domain of unknown function (DUF4867); This family consists of uncharacterized proteins around 220 residues in length and is mainly found in various human gut Firmicutes and a few eubacteria species. It is also amply represented in human gut metagenomic datasets. Distant homology analysis and marginal HMM overlaps suggest this family is a distant homolog of Ureidoglycolate hydrolase pfam04115, but this prediction is not verified by experiment, therefore the function of this family is still unknown.


Pssm-ID: 435181  Cd Length: 199  Bit Score: 199.33  E-value: 4.18e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582115   10 SIHSDEFRPYGNVISAINVDSLLKYLkEEISVPEDqVAYVRSDERLKQYPAVSDIQRQIYGGMPVQAGYVCGVNTTQDGF 89
Cdd:pfam16161   1 SVTDPAFKKYGRVLTGYDFSELLKAM-EKTPLPEG-VIYVPSVPELEALPVAKELQDRVYGGLPIQIGYCNGHNTKLNAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582115   90 EYHQGSEVIIAASDFFLFLGKRELMQGD-TFNGERAEPFFIPAKSVIELYSTTLHYCPMSINAQPFSAAIILLDGTNEDI 168
Cdd:pfam16161  79 EYHRSSEINIAVTDLILLLGKQQDIEEDfTYDTSKVEAFFVPAGTAVEVYATTLHYAPCGVDGKGFKCIVVLPKGTNTPL 158

                         170       180
                  ....*....|....*....|....
gi 505582115  169 DGKNKPT----ILSKRNTWFIAHE 188
Cdd:pfam16161 159 PEPTGKNgedkLLFAKNKWLIAHP 182
 
Name Accession Description Interval E-value
DUF4867 pfam16161
Domain of unknown function (DUF4867); This family consists of uncharacterized proteins around ...
 10-188 4.18e-65

Domain of unknown function (DUF4867); This family consists of uncharacterized proteins around 220 residues in length and is mainly found in various human gut Firmicutes and a few eubacteria species. It is also amply represented in human gut metagenomic datasets. Distant homology analysis and marginal HMM overlaps suggest this family is a distant homolog of Ureidoglycolate hydrolase pfam04115, but this prediction is not verified by experiment, therefore the function of this family is still unknown.


Pssm-ID: 435181  Cd Length: 199  Bit Score: 199.33  E-value: 4.18e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582115   10 SIHSDEFRPYGNVISAINVDSLLKYLkEEISVPEDqVAYVRSDERLKQYPAVSDIQRQIYGGMPVQAGYVCGVNTTQDGF 89
Cdd:pfam16161   1 SVTDPAFKKYGRVLTGYDFSELLKAM-EKTPLPEG-VIYVPSVPELEALPVAKELQDRVYGGLPIQIGYCNGHNTKLNAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505582115   90 EYHQGSEVIIAASDFFLFLGKRELMQGD-TFNGERAEPFFIPAKSVIELYSTTLHYCPMSINAQPFSAAIILLDGTNEDI 168
Cdd:pfam16161  79 EYHRSSEINIAVTDLILLLGKQQDIEEDfTYDTSKVEAFFVPAGTAVEVYATTLHYAPCGVDGKGFKCIVVLPKGTNTPL 158

                         170       180
                  ....*....|....*....|....
gi 505582115  169 DGKNKPT----ILSKRNTWFIAHE 188
Cdd:pfam16161 159 PEPTGKNgedkLLFAKNKWLIAHP 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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