NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|505807087|ref|WP_015704842|]
View 

serine-type D-Ala-D-Ala carboxypeptidase [Klebsiella aerogenes]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK10001 super family cl32450
serine-type D-Ala-D-Ala carboxypeptidase;
1-400 0e+00

serine-type D-Ala-D-Ala carboxypeptidase;


The actual alignment was detected with superfamily member PRK10001:

Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 804.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087   1 MTHDAFSLRGLAAGCALLLLVAPAVQAADQLPDAPSIDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQAL 80
Cdd:PRK10001   1 MTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  81 KAGKIKLTDTVTVGRDAWATGNPALRGSSVMFLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQ 160
Cdd:PRK10001  81 KADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 161 KIGLTNTTFKTVHGLDAPGQFSTARDMALLTKAMIHDVPEEYAVHKEKEFTFNKIRQPNRNRLLWSTNLNADGVKTGTTA 240
Cdd:PRK10001 161 KLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 241 GAGYNLVSSATQGDMRLIAVVLGTKTDRIRFNESEKLLTWGFRFYETVTPIKPDATFISQRVWFGDSNEVKLGAGEAGSV 320
Cdd:PRK10001 241 GAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 321 TIPRGQLKNLKASYNLTEPQLTAPLAKGQVVGTIDFKLNDKTIEQRPLIVMEDVKEGGFFSRIVDFVLMKLHGWFGSWFS 400
Cdd:PRK10001 321 TIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFSRMWDFVMMKFHQWFGSWFS 400
 
Name Accession Description Interval E-value
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
1-400 0e+00

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 804.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087   1 MTHDAFSLRGLAAGCALLLLVAPAVQAADQLPDAPSIDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQAL 80
Cdd:PRK10001   1 MTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  81 KAGKIKLTDTVTVGRDAWATGNPALRGSSVMFLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQ 160
Cdd:PRK10001  81 KADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 161 KIGLTNTTFKTVHGLDAPGQFSTARDMALLTKAMIHDVPEEYAVHKEKEFTFNKIRQPNRNRLLWSTNLNADGVKTGTTA 240
Cdd:PRK10001 161 KLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 241 GAGYNLVSSATQGDMRLIAVVLGTKTDRIRFNESEKLLTWGFRFYETVTPIKPDATFISQRVWFGDSNEVKLGAGEAGSV 320
Cdd:PRK10001 241 GAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 321 TIPRGQLKNLKASYNLTEPQLTAPLAKGQVVGTIDFKLNDKTIEQRPLIVMEDVKEGGFFSRIVDFVLMKLHGWFGSWFS 400
Cdd:PRK10001 321 TIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFSRMWDFVMMKFHQWFGSWFS 400
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
24-382 5.26e-143

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 409.61  E-value: 5.26e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  24 AVQAADQLPDAPSIDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQALKAGKIKLTDTVTVGRDAWATGnp 103
Cdd:COG1686   13 LAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKISLDDKVTVSEEAARTG-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 104 alrgSSVMFLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQKIGLTNTTFKTVHGLDAPGQFST 183
Cdd:COG1686   91 ----GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNTHFVNPTGLPDPGHYST 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 184 ARDMALLTKAMIHDVPEEYAVHKEKEFTFN---KIRQPNRNRLLWSTNlNADGVKTGTTAGAGYNLVSSATQGDMRLIAV 260
Cdd:COG1686  167 ARDLALLARAAIKDYPEFYEIFSTKEFTFPngrGITLRNTNRLLGRYP-GVDGLKTGYTDAAGYCLVASAKRGGRRLIAV 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 261 VLGTKTDRIRFNESEKLLTWGFrfyetvtpikpdatfisqrvwfgdsnevklgageagsvtiPRGQlkNLKASYNLTEPq 340
Cdd:COG1686  246 VLGAPSEKARFADAAKLLDYGF----------------------------------------PKGE--ALKAEVVLDGP- 282

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 505807087 341 LTAPLAKGQVVGTIDFKLNDKTIEQRPLIVMEDVKEGGFFSR 382
Cdd:COG1686  283 LKAPVKKGQVVGTLVVTLDGKTIAEVPLVAAEDVEKAGFFSR 324
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
32-265 8.58e-123

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 354.77  E-value: 8.58e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087   32 PDAPSIDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQALKAGKIKLTDTVTVGRDAWATGNPalrGSSVM 111
Cdd:pfam00768   1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP---GSSNI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  112 FLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQKIGLTNTTFKTVHGLDAPGQFSTARDMALLT 191
Cdd:pfam00768  78 FLKPGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHGQYSSARDMAILA 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505807087  192 KAMIHDVPEEYAVHKEKEFTF---NKIRQPNRNRLLWSTNLNADGVKTGTTAGAGYNLVSSATQGDMRLIAVVLGTK 265
Cdd:pfam00768 158 KALIKDLPEELSITKEKSFTFrgiNKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATKGGMRLISVVMGAF 234
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 285-376 5.58e-31

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 113.47  E-value: 5.58e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087   285 YETVTPIKPDATFISQRVWFGDSNEVKLGAGEAGSVTIPRGQLKNLKASYNLTEPQLTAPLAKGQVVGTIDFKLNDKTIE 364
Cdd:smart00936   1 FETVKLYKKGQVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVTLDGKLIG 80

                           90
                   ....*....|..
gi 505807087   365 QRPLIVMEDVKE 376
Cdd:smart00936  81 EVPLVALEDVEK 92
 
Name Accession Description Interval E-value
PRK10001 PRK10001
serine-type D-Ala-D-Ala carboxypeptidase;
1-400 0e+00

serine-type D-Ala-D-Ala carboxypeptidase;


Pssm-ID: 182189 [Multi-domain]  Cd Length: 400  Bit Score: 804.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087   1 MTHDAFSLRGLAAGCALLLLVAPAVQAADQLPDAPSIDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQAL 80
Cdd:PRK10001   1 MTQYSSLLRGLAAGSAFLFLFAPTAFAAEQTVEAPSVDARAWILMDYASGKVLAEGNADEKLDPASLTKIMTSYVVGQAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  81 KAGKIKLTDTVTVGRDAWATGNPALRGSSVMFLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQ 160
Cdd:PRK10001  81 KADKIKLTDMVTVGKDAWATGNPALRGSSVMFLKPGDQVSVADLNKGVIIQSGNDACIALADYVAGSQESFIGLMNGYAK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 161 KIGLTNTTFKTVHGLDAPGQFSTARDMALLTKAMIHDVPEEYAVHKEKEFTFNKIRQPNRNRLLWSTNLNADGVKTGTTA 240
Cdd:PRK10001 161 KLGLTNTTFQTVHGLDAPGQFSTARDMALLGKALIHDVPEEYAIHKEKEFTFNKIRQPNRNRLLWSSNLNVDGMKTGTTA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 241 GAGYNLVSSATQGDMRLIAVVLGTKTDRIRFNESEKLLTWGFRFYETVTPIKPDATFISQRVWFGDSNEVKLGAGEAGSV 320
Cdd:PRK10001 241 GAGYNLVASATQGDMRLISVVLGAKTDRIRFNESEKLLTWGFRFFETVTPIKPDATFVTQRVWFGDKSEVNLGAGEAGSV 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 321 TIPRGQLKNLKASYNLTEPQLTAPLAKGQVVGTIDFKLNDKTIEQRPLIVMEDVKEGGFFSRIVDFVLMKLHGWFGSWFS 400
Cdd:PRK10001 321 TIPRGQLKNLKASYTLTEPQLTAPLKKGQVVGTIDFQLNGKSIEQRPLIVMENVEEGGFFSRMWDFVMMKFHQWFGSWFS 400
PRK10793 PRK10793
D-alanyl-D-alanine carboxypeptidase fraction A; Provisional
 31-396 0e+00

D-alanyl-D-alanine carboxypeptidase fraction A; Provisional


Pssm-ID: 182736 [Multi-domain]  Cd Length: 403  Bit Score: 568.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  31 LPDAPSIDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQALKAGKIKLTDTVTVGRDAWATGNPALRGSSV 110
Cdd:PRK10793  38 IPGVPQIDAESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMKAGKFKETDLVTVGNDAWATGNPVFKGSSL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 111 MFLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQKIGLTNTTFKTVHGLDAPGQFSTARDMALL 190
Cdd:PRK10793 118 MFLKPGMQVPVSQLIRGINLQSGNDACVAMADYVAGSQDAFVGLMNSYVNALGLKNTHFQTVHGLDADGQYSSARDMALI 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 191 TKAMIHDVPEEYAVHKEKEFTFNKIRQPNRNRLLWSTNLNADGVKTGTTAGAGYNLVSSATQGDMRLIAVVLGTKTDRIR 270
Cdd:PRK10793 198 GQALIRDVPNEYAIYKEKEFTFNGIRQLNRNGLLWDNSLNVDGIKTGHTDKAGYNLVASATEGQMRLISAVMGGRTFKGR 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 271 FNESEKLLTWGFRFYETVTPIKPDATFISQRVWFGDSNEVKLGAGEAGSVTIPRGQLKNLKASYNLTEPQLTAPLAKGQV 350
Cdd:PRK10793 278 ETESKKLLTWGFRFFETVNPLKVGKEFASEPVWFGDSDRASLGVDKDVYLTIPRGRMKDLKASYVLNTSELHAPLQKNQV 357

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 505807087 351 VGTIDFKLNDKTIEQRPLIVMEDVKEGGFFSRIVDFVLMKLHGWFG 396
Cdd:PRK10793 358 VGTINFQLDGKTIEQRPLVVLQEIPEGNFFGKIIDYIKLMFHHWFG 403
dacD PRK11397
serine-type D-Ala-D-Ala carboxypeptidase DacD;
24-391 7.99e-158

serine-type D-Ala-D-Ala carboxypeptidase DacD;


Pssm-ID: 183117 [Multi-domain]  Cd Length: 388  Bit Score: 449.66  E-value: 7.99e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  24 AVQAADQLPDAPSIDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQALKAGKIKLTDTVTVGRDAWATGNP 103
Cdd:PRK11397  21 AAENIPFSPQPPAIDAGSWVLMDYTTGQILTAGNEHQQRNPASLTKLMTGYVVDRAIDSHRITPDDIVTVGRDAWAKDNP 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 104 ALRGSSVMFLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQKIGLTNTTFKTVHGLDAPGQFST 183
Cdd:PRK11397 101 VFVGSSLMFLKEGDRVSVRDLSRGLIVDSGNDACVALADYIAGGQRQFVEMMNNYVEKLHLKDTHFETVHGLDAPGQHSS 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 184 ARDMALLTKAMIHDVPEEYAVHKEKEFTFNKIRQPNRNRLLWSTNLNADGVKTGTTAGAGYNLVSSATQGDMRLIAVVLG 263
Cdd:PRK11397 181 AYDLAVLSRAIIHGEPEFYHMYSEKSLTWNGITQQNRNGLLWDKTMNVDGLKTGHTSGAGFNLIASAVDGQRRLIAVVMG 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 264 TKTDRIRFNESEKLLTWGFRFYETVTPIKPDATFISQRVWFGDSNEVKLGAGEAGSVTIPRGQLKNLKASYNLTEPQLTA 343
Cdd:PRK11397 261 ADSAKGREEQARKLLRWGQQNFTTVQILHRGKKVGTERIWYGDKENIALGTEQDFWMVLPKAEIPHIKAKYVLDGKELEA 340

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 505807087 344 PLAKGQVVGTIDFKLNDKTIEQRPLIVMEDVKEGGFFSRIVDFVLMKL 391
Cdd:PRK11397 341 PISAHQRVGEIELYDRDKQVAHWPLVTLESVGEGGMFSRLSDYFHHKA 388
DacC COG1686
D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];
24-382 5.26e-143

D-alanyl-D-alanine carboxypeptidase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441292 [Multi-domain]  Cd Length: 324  Bit Score: 409.61  E-value: 5.26e-143
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  24 AVQAADQLPDAPSIDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQALKAGKIKLTDTVTVGRDAWATGnp 103
Cdd:COG1686   13 LAAAAAAPAAPPDIAAKSAILIDADTGQVLYEKNADERLPPASLTKLMTAYVVLEALKAGKISLDDKVTVSEEAARTG-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 104 alrgSSVMFLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQKIGLTNTTFKTVHGLDAPGQFST 183
Cdd:COG1686   91 ----GSKMGLKPGEQVTVEDLLKGLLLQSGNDAAVALAEHIAGSEEAFVALMNAKAKELGMTNTHFVNPTGLPDPGHYST 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 184 ARDMALLTKAMIHDVPEEYAVHKEKEFTFN---KIRQPNRNRLLWSTNlNADGVKTGTTAGAGYNLVSSATQGDMRLIAV 260
Cdd:COG1686  167 ARDLALLARAAIKDYPEFYEIFSTKEFTFPngrGITLRNTNRLLGRYP-GVDGLKTGYTDAAGYCLVASAKRGGRRLIAV 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 261 VLGTKTDRIRFNESEKLLTWGFrfyetvtpikpdatfisqrvwfgdsnevklgageagsvtiPRGQlkNLKASYNLTEPq 340
Cdd:COG1686  246 VLGAPSEKARFADAAKLLDYGF----------------------------------------PKGE--ALKAEVVLDGP- 282

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 505807087 341 LTAPLAKGQVVGTIDFKLNDKTIEQRPLIVMEDVKEGGFFSR 382
Cdd:COG1686  283 LKAPVKKGQVVGTLVVTLDGKTIAEVPLVAAEDVEKAGFFSR 324
Peptidase_S11 pfam00768
D-alanyl-D-alanine carboxypeptidase;
32-265 8.58e-123

D-alanyl-D-alanine carboxypeptidase;


Pssm-ID: 425859 [Multi-domain]  Cd Length: 234  Bit Score: 354.77  E-value: 8.58e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087   32 PDAPSIDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQALKAGKIKLTDTVTVGRDAWATGNPalrGSSVM 111
Cdd:pfam00768   1 VSAPEIAAKSAILVDYNTGKVLYEKNPDQVRPIASITKLMTAYVVLEALKAGKIKEDDMVTISEDAWATGNP---GSSNI 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  112 FLKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQKIGLTNTTFKTVHGLDAPGQFSTARDMALLT 191
Cdd:pfam00768  78 FLKPGSQVSVKDLLRGALVSSGNDAAVALAEHIAGSEKAFVK*MNAKAKELGLKNTRFVNPTGLDAHGQYSSARDMAILA 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505807087  192 KAMIHDVPEEYAVHKEKEFTF---NKIRQPNRNRLLWSTNLNADGVKTGTTAGAGYNLVSSATQGDMRLIAVVLGTK 265
Cdd:pfam00768 158 KALIKDLPEELSITKEKSFTFrgiNKINQRNRNGLLWDKTWNVDGLKTGYTNEAGYCLVASATKGGMRLISVVMGAF 234
PBP5_C smart00936
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 285-376 5.58e-31

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 198004 [Multi-domain]  Cd Length: 92  Bit Score: 113.47  E-value: 5.58e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087   285 YETVTPIKPDATFISQRVWFGDSNEVKLGAGEAGSVTIPRGQLKNLKASYNLTEPQLTAPLAKGQVVGTIDFKLNDKTIE 364
Cdd:smart00936   1 FETVKLYKKGQVVGTVKVWKGKEKTVKLGAKEDVYVTLPKGEKKKLKAKVVLDKPELEAPIKKGQVVGTLVVTLDGKLIG 80

                           90
                   ....*....|..
gi 505807087   365 QRPLIVMEDVKE 376
Cdd:smart00936  81 EVPLVALEDVEK 92
PBP5_C pfam07943
Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. ...
 285-376 9.46e-29

Penicillin-binding protein 5, C-terminal domain; Penicillin-binding protein 5 expressed by E. coli functions as a D-alanyl-D-alanine carboxypeptidase. It is composed of two domains that are oriented at approximately right angles to each other. The N-terminal domain (pfam00768) is the catalytic domain. The C-terminal domain featured in this family is organized into a sandwich of two anti-parallel beta-sheets, and has a relatively hydrophobic surface as compared to the N-terminal domain. Its precise function is unknown; it may mediate interactions with other cell wall-synthesising enzymes, thus allowing the protein to be recruited to areas of active cell wall synthesis. It may also function as a linker domain that positions the active site in the catalytic domain closer to the peptidoglycan layer, to allow it to interact with cell wall peptides.


Pssm-ID: 429749 [Multi-domain]  Cd Length: 91  Bit Score: 107.68  E-value: 9.46e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  285 YETVTPIKPDATFISQRVWFGDSNEVKLGAGEAGSVTIPRGQLKNLKASYNLTEPqLTAPLAKGQVVGTIDFKLNDKTIE 364
Cdd:pfam07943   1 FETKKLYKKGDVVKKVKVWKGKKKTVPLGAKEDVYVTVPKGEKKKLKAKVTLKKP-LEAPIKKGQVVGKLEVYLDGKLIG 79

                          90
                  ....*....|..
gi 505807087  365 QRPLIVMEDVKE 376
Cdd:pfam07943  80 EVPLVAKEDVEE 91
pbpG PRK11669
D-alanyl-D-alanine endopeptidase; Provisional
 23-295 1.62e-17

D-alanyl-D-alanine endopeptidase; Provisional


Pssm-ID: 236952  Cd Length: 306  Bit Score: 82.42  E-value: 1.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  23 PAVQAADQLPDAPS----IDARAWILMDYASGKVLSEGNADEKLDPASLTKIMTSYVVGQAlkagKIKLTDTVTVGrdaw 98
Cdd:PRK11669  21 PQAVAKTAAATTASqpqeIASGSAMVVDLNTNKVIYSSNPDLVVPIASITKLMTAMVVLDA----KLPLDEKLKVD---- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  99 ATGNPALRG--SSVmflKPGMQVSVEDLNKGVIIQSGNDASIAIADYVAGSQDSFVNLMNGYAQKIGLTNTTFKTVHGLd 176
Cdd:PRK11669  93 ISQTPEMKGvySRV---RLNSEISRKDMLLLALMSSENRAAASLAHHYPGGYKAFIKAMNAKAKALGMTNTRYVEPTGL- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087 177 APGQFSTARDMALLTKAMiHDVP--EEYAVHKEKEFTFnkiRQP-------NRNRLLWSTNLNADGVKTGTTAGAGYNLV 247
Cdd:PRK11669 169 SIHNVSTARDLTKLLIAS-KQYPliGQLSTTREKTATF---RKPnytlpfrNTNHLVYRDNWNIQLTKTGFTNAAGHCLV 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 505807087 248 SSaTQGDMRLIA-VVLGTKTDRIRFNESEKLLTWgfrfYET--VTPIKPDA 295
Cdd:PRK11669 245 MR-TVINNRPVAlVVLDAFGKYTHFADASRLRTW----IETgkVTPVPAAA 290
Beta-lactamase2 pfam13354
Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is ...
 44-197 8.15e-13

Beta-lactamase enzyme family; This is the catalytic domain of class A beta-lactamases. It is closely related to Beta-lactamase, pfam00144, the serine beta-lactamase-like superfamily, which contains the distantly related pfam00905 and PF00768 D-alanyl-D-alanine carboxypeptidase.


Pssm-ID: 463854 [Multi-domain]  Cd Length: 215  Bit Score: 66.91  E-value: 8.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087   44 LMDYASGKVLSEgNADEKLDPASLTKIMTSYVVGQALKAGKIKLTDTVTVGRDAWATGNPALRgssvmFLKPGMQVSVED 123
Cdd:pfam13354   4 VRDLDTGEELGI-NGDRSFPAASTIKVPILLAVLEQVDEGKLSLDERLTVTAEDKVGGSGILQ-----YLPDGSQLSLRD 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505807087  124 LNKGVIIQSGNDASIAIADYVAGSQdsfvnlMNGYAQKIGLTNTTF----KTVHGLDAPGQ-FSTARDMALLTKAMIHD 197
Cdd:pfam13354  78 LLTLMIAVSDNTATNLLIDRLGLEA------VNARLRALGLRDTRLrrklPDLRAADKGGTnTTTARDMAKLLEALYRG 150
PenP COG2367
Beta-lactamase class A [Defense mechanisms];
38-190 4.41e-10

Beta-lactamase class A [Defense mechanisms];


Pssm-ID: 441934 [Multi-domain]  Cd Length: 276  Bit Score: 59.91  E-value: 4.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505807087  38 DARAWI-LMDYASGKVLSEgNADEKLDPASLTKIMTSYVVGQALKAGKIKLTDTVTVGRDAWATGNPALRgssvmFLKPG 116
Cdd:COG2367   32 GGRVGVyVLDLDTGETVGI-NADERFPAASTFKLPVLAAVLRQVDAGKLSLDERVTLTPEDLVGGSGILQ-----KLPDG 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 505807087 117 MQVSVEDLNKGVIIQSGNDASIAIADYVAGSQdsfvnlMNGYAQKIGLTNTTF--KTVHGLDAPGQF---STARDMALL 190
Cdd:COG2367  106 TGLTLRELAELMITVSDNTATNLLLRLLGPDA------VNAFLRSLGLTDTRLdrKEPDLNELPGDGrntTTPRDMARL 178
AmpC COG1680
CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];
65-92 6.13e-03

CubicO group peptidase, beta-lactamase class C family [Defense mechanisms];


Pssm-ID: 441286 [Multi-domain]  Cd Length: 355  Bit Score: 38.51  E-value: 6.13e-03
                         10        20
                 ....*....|....*....|....*...
gi 505807087  65 ASLTKIMTSYVVGQALKAGKIKLTDTVT 92
Cdd:COG1680   71 ASVTKSFTATAVLQLVEEGKLDLDDPVS 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH