|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
21-451 |
4.56e-73 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 234.37 E-value: 4.56e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 21 IVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICAL 100
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 101 SRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLG 180
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 181 IISIFLAmrflppnssaskitrfdlpsammnaltfgllitalggfaqgqsgylvlaeviamliigfffvrrqlrmpvpll 260
Cdd:cd17321 161 LVALLLA------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 261 pvdllriPIFSLSICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMG 340
Cdd:cd17321 168 -------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 341 LLIMACGLFGLALLPSSPSDLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALLF 420
Cdd:cd17321 241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
410 420 430
....*....|....*....|....*....|.
gi 505808183 421 NLAGNSGTHTALLLAGSLAVIAAAISGLRVT 451
Cdd:cd17321 321 TAGLSANLGDSGVAALLSAAAAAFAAGFHLA 351
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
17-416 |
2.12e-56 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 194.13 E-value: 2.12e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 17 AILTIVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSL 96
Cdd:TIGR00711 3 LTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 97 ICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLIN 176
Cdd:TIGR00711 83 LCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLIN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 177 VPLGIISIFLAMRFLPPNSSASKItRFDLPSAMMNALTFGLLitaLGGFAQGQS-GYLVLAEVIAMLIIGF----FFVRR 251
Cdd:TIGR00711 163 VPIGIIVVVVAFFILPRDKPAASE-NFDFLGLLLLSVGLGSL---LYGLSEGPErGWFDSNEILILSITGLvaiiAFVVW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 252 QLRMPVPLLPVDLLRIPIFSLSICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKV 331
Cdd:TIGR00711 239 ELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 332 HAGLLGAMGLLIMA--CGLFGLALLPSSPSdLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQ 409
Cdd:TIGR00711 319 DPRKLVTIGLILYAvgFYWRAFTFTPDTPF-LAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGG 397
|
....*..
gi 505808183 410 SSGAALV 416
Cdd:TIGR00711 398 SIGTALI 404
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
21-451 |
6.11e-55 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 187.40 E-value: 6.11e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 21 IVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICAL 100
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 101 SRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLG 180
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 181 IISIFLAmrflppnssaskitrfdlpsammnaltfgllitalggfaqgqsgylvlaeviamliigfffvrrqlrmpvPLL 260
Cdd:cd17503 161 ILALLLA----------------------------------------------------------------------PLL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 261 PVDLLRIPIFSLSICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMG 340
Cdd:cd17503 171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 341 LLIMACGLFGLALLPSSPSDLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALLF 420
Cdd:cd17503 251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330
|
410 420 430
....*....|....*....|....*....|.
gi 505808183 421 NLAGNSGTHTALLLAGSLAVIAAAISGLRVT 451
Cdd:cd17503 331 TNRTQFHHSRLSELLAQQVQKQALIIAFNDA 361
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
23-415 |
4.70e-37 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 138.47 E-value: 4.70e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 23 LGLTMAVLDGAIANVALPTIATDLNASPASSiWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSR 102
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 103 SLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGII 182
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 183 SIFLamrflppnssaskitrfdlpsammnaltfgllitalggfaqgqsgylvlaeviamliigfffvrrqlrmpvpllpv 262
Cdd:cd17502 162 ALAL---------------------------------------------------------------------------- 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 263 dllrIPIFSLSICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEK-VHAGLLGAMGL 341
Cdd:cd17502 166 ----LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKtGRYKPLIVIGT 241
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505808183 342 LIMACGLFGLALLPSSPSDLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAAL 415
Cdd:cd17502 242 ILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-410 |
5.87e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 138.57 E-value: 5.87e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 10 PVPQRYGAILTIVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLV 89
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 90 VFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASW 169
Cdd:COG2814 84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 170 QWLFLINVPLGIISIFLAMRFLPPnssaskitrfdlpsammnaltfgllitalggfaqgqsgylvlaeviamliigfffV 249
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLLPE-------------------------------------------------------S 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 250 RRQLRMPVPLLPVDLLRIPIFSLSICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIE 329
Cdd:COG2814 189 RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 330 KVHAGLLGAMGLLIMACGLFGLALLPSSPSdldIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQ 409
Cdd:COG2814 269 RFGRRRLLLIGLLLLALGLLLLALAGSLWL---LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
.
gi 505808183 410 S 410
Cdd:COG2814 346 P 346
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
17-419 |
1.76e-30 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 123.30 E-value: 1.76e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 17 AILTIVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSL 96
Cdd:PRK14995 7 TLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 97 ICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIY-PKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLI 175
Cdd:PRK14995 87 AAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 176 NVPLGIISIFLAMRFLPPNSSASKITrFDLPSAMMNALTFGLLITALggfAQGQSGYLVLAEVIAMLIIG----FFFVRR 251
Cdd:PRK14995 167 NVPIVLVVMGLTARYVPRQAGRRDQP-LNLGHALMLIVAILLLVYSA---KTALKGFLSLWVTSLTLLTGalllGLFIRT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 252 QLRMPVPLLPVDLLRIPIFSLSICTSicsfcaqMLAMVSLPFF-------LQTVIGRSEVETGLLLTPWPLATMVMAPLA 324
Cdd:PRK14995 243 QLAASRPMIDMRLFTHRIILSGVVMA-------MTAMITLVGFellmaqeLQFVHGLSPLEAGMFMLPVMVASGFSGPIA 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 325 GYLIEKVHAGLLGAMGLLIMACGLFGLALLPSSPSDLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTA 404
Cdd:PRK14995 316 GILVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMA 395
|
410
....*....|....*
gi 505808183 405 RLLGQSSGAALVALL 419
Cdd:PRK14995 396 YELGAGLGIAIFGLL 410
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
38-446 |
5.20e-30 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 119.99 E-value: 5.20e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 38 ALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLG 117
Cdd:cd17504 18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 118 GAALmSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLamrflppnssa 197
Cdd:cd17504 98 GAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL----------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 198 skitrfdlpsammnaltfgllitalggfaqgqsgylvlaeviamliigfffvrrqlrmpVPLLPVDLLRIPIFSLSICTS 277
Cdd:cd17504 166 -----------------------------------------------------------VPLIDLRLLRRRNVLLANITA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 278 ICSFCAQMLAMVSLPFFLQ----TVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFGLAL 353
Cdd:cd17504 187 LLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLAL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 354 LPSSPsdLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALL----------FNLA 423
Cdd:cd17504 267 LHSSL--WALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsGGVP 344
|
410 420
....*....|....*....|...
gi 505808183 424 GNSGTHTALLLAGSLAVIAAAIS 446
Cdd:cd17504 345 TEGAYVLAFLIGAALALAALLLS 367
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
21-320 |
2.10e-28 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 117.14 E-value: 2.10e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 21 IVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICAL 100
Cdd:PRK10504 15 VAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 101 SRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLG 180
Cdd:PRK10504 95 SGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 181 IISIfLAMRFLPPNSSASKiTRFDLPSAMMNALTFGLLITALGGF-AQGQSGYLVLAEVIAMLIIGFFFVRRQLRMPVPL 259
Cdd:PRK10504 175 IIGA-IATLMLMPNYTMQT-RRFDLSGFLLLAVGMATLTLALDGSkGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRAL 252
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 505808183 260 LPVDLLRIPIFSLSICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVM 320
Cdd:PRK10504 253 FSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGM 313
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-274 |
6.09e-28 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 112.60 E-value: 6.09e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 6 LDGLPVPQRYGAILTIVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYK 85
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 86 IGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILS 165
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 166 LASWQWLFLINVPLGIISIFLAMRFLPPNSSASKITRFDLPSAMMNALTFGLLITALGGFAQGQSGYLVLAEVIAMLIIG 245
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
250 260
....*....|....*....|....*....
gi 505808183 246 FFFVRRQLRMPVPLLPVDLLRIPIFSLSI 274
Cdd:COG0477 244 ALLLLALLLLLALLLLAALLLLLLLLLLL 272
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
27-445 |
6.64e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 111.12 E-value: 6.64e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 27 MAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEM 106
Cdd:cd17474 10 LAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 107 LTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPtIAAAILSLASWQWLFLInVPLGIISIFL 186
Cdd:cd17474 90 LLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGP-LLGGLLAAISWRYPFFL-LAALIPVAFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 187 AMRFLPPNSSASKITRFDLPSAMMnaltfgllitalgGFAQGQSGYLVLAEVIAMLIIGFFFVrrqlrmpvpllpvdllr 266
Cdd:cd17474 168 AILFLLPEPKEKAKSSSATKLRDL-------------KKALRGRGLLTFLVSAFLYFFLYFAF----------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 267 ipifslsictsicsfcaqmlaMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEK-VHAGLLGAMGLLIMA 345
Cdd:cd17474 218 ---------------------LTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYA 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 346 CGLFGLALLPSSPSDLDIIwrmALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALlfnLAGN 425
Cdd:cd17474 277 LSLLLLGFVPSLALLLIAI---VLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGL---LLEI 350
|
410 420
....*....|....*....|
gi 505808183 426 SGTHTALLLAGSLAVIAAAI 445
Cdd:cd17474 351 FGLSAPFLVGAAIALAAAVL 370
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-450 |
1.22e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 107.66 E-value: 1.22e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 21 IVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICAL 100
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 101 SRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLG 180
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 181 IISIFLAMRFLPPNSSASKITrfdlpsammnaltfgllitalggfaqgqsgylvlaeviamliigfffvRRQLRMPVPLL 260
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKR------------------------------------------------AVSAARLRSGL 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 261 PVDLLRIPIFSLSICTSICSFCAQMLAMVsLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMG 340
Cdd:cd17325 193 RLLLRDRRLLALFLAIFVLAFAFGALEPF-LPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 341 LLIMAcglFGLALLPSSPSDLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALLF 420
Cdd:cd17325 272 LLLSA---VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLY 348
|
410 420 430
....*....|....*....|....*....|
gi 505808183 421 NLAGNSgthTALLLAGSLAVIAAAISGLRV 450
Cdd:cd17325 349 DAFGFA---TPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
38-445 |
2.05e-24 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 104.19 E-value: 2.05e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 38 ALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLG 117
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 118 GAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPNSSA 197
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPE 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 198 SKITRFdlpsammnaltfglLITALGGFAQgqsgylvlaeviamliigfffvrrqlrmpvpllpvdLLRIPIFSLSICTS 277
Cdd:cd17320 181 EKRKPL--------------LSSLLRAYKR------------------------------------VLKNRRFLGYALAL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 278 ICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFGLAL--LP 355
Cdd:cd17320 211 GLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLaaLL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 356 SSPSDLDIIWRMALCGAGFGlFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALLFNlAGNSGTHTALLLA 435
Cdd:cd17320 291 GGLSLWPLVAPLFLIFFGFG-LIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN-GTALPMGLLILVL 368
|
410
....*....|
gi 505808183 436 GSLAVIAAAI 445
Cdd:cd17320 369 GLLALLLLIL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-413 |
6.29e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.11 E-value: 6.29e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 21 IVLGLTMAVLDGAIANVALP-TIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICA 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 100 LSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPL 179
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 180 GIISIFLAMRFLPPNSSASKITRFDLPsammnaltfgllitalggfaqgqsgylvlaeviamliigfffvrrqlrmPVPL 259
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEAR-------------------------------------------------LSLI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 260 LPVDLLRIPIFSLSICTSICSFCAQMLAMVSLPFFlQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAM 339
Cdd:pfam07690 192 VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505808183 340 GLLIMACGLFGLALLPSSPSDLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGA 413
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-448 |
1.84e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 101.10 E-value: 1.84e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 7 DGLPVPQRYGAILTIVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKI 86
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 87 GLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSL 166
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 167 ASWQWLFLINVPLGIIsiflamrflppnssaskitrfdlpsammnaltfgllitalggfaqgqsgyLVLAEVIAMLIIGF 246
Cdd:COG2271 161 FGWRAAFLILGLPGLL--------------------------------------------------LALLRFWLLALAYF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 247 FFVrrqlrmpvpllpvdllripifslsictsicsfCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGY 326
Cdd:COG2271 191 LVY--------------------------------FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGW 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 327 LIEKVHAGLLGAMgLLIMACGLFGLALLPSSPSDLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARL 406
Cdd:COG2271 239 LSDRLGRRRKLVL-AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF 317
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 505808183 407 LGQSSGAALVALLFNLagnSGTHTALLLAGSLAVIAAAISGL 448
Cdd:COG2271 318 LGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
39-446 |
4.30e-23 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 100.32 E-value: 4.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 39 LPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGG 118
Cdd:cd17324 22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 119 AALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPNSSAS 198
Cdd:cd17324 102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 199 KITRFDLPSammnaltfgllitalggfaqgqsgylvlaeviamliigfffvrrqlrmpvpllPVDLLRIPIFSLSICTSI 278
Cdd:cd17324 182 PGSLGLLSS-----------------------------------------------------LLLLLRNPRLRLAYLITF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 279 CSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFGLALLPSSP 358
Cdd:cd17324 209 LLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 359 SdldIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRsGGASGMLGTARLLGQSSGAALVALLFNLAGNSGThtaLLLAGSL 438
Cdd:cd17324 289 L---LLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGV---GWVGAAL 361
|
....*...
gi 505808183 439 AVIAAAIS 446
Cdd:cd17324 362 LLLALLLA 369
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
19-449 |
9.80e-22 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 96.10 E-value: 9.80e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 19 LTIVLGLTMAVLDGAIANVALPTIATDLNASPASSI-WIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLI 97
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVpLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 98 CALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLaSWQWLFLINV 177
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 178 pLGIISIFLAMRFLP---PNSSASKITRFDLPSAMMNALTFGLLITALGGFaqgqsgylvlaeviamliIGFFFVrrqlr 254
Cdd:cd17473 161 -LALPVLILVLLFLPepaRKSKSAASPGAATAAALPWKRVLPIYFLAFLAM------------------LLFYVI----- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 255 mpvpllpvdllripifslsictsicsfcaqmlaMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAG 334
Cdd:cd17473 217 ---------------------------------PIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKR 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 335 LLGAMGLLIMACGLFGLALLPSSPSdldIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAA 414
Cdd:cd17473 264 RLLAIGFALMALGFLLLALASGLWV---VLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
|
410 420 430
....*....|....*....|....*....|....*
gi 505808183 415 LVALLFNLAGnsGTHTALLLAGSLAVIAAAISGLR 449
Cdd:cd17473 341 VLGPLVNLTG--GLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
23-421 |
2.44e-19 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 90.38 E-value: 2.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 23 LGLTMAVLDGAIANVALPTIATDLNA---SPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICA 99
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVAdlgPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 100 LSRSLEMLTLARVAQGLGGAALMSVNtALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAIL--SLASWQWLFLINV 177
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTQGLGA-AVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVeaNAAGWRWIFYINA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 178 PLGIISIFLAMRFL-PPN-------SSASKITRFDLPSammnaltFGLLITALG----GFAQGQSGY-LVLAEVIAMLII 244
Cdd:cd06179 160 IFNALALILLFFFYhPPPrpqlhgsSTRQKLKRLDWVG-------LFLLIAGLVlfllGLSWGGNPYpWSSAHVIAPLVI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 245 GFF----FVRRQLRMPV--PLLPVDLLRIPIFSLSIctsICSFCAQMLAMVSLPFFLQTVIGRSE---VETGLLLTPWPL 315
Cdd:cd06179 233 GGVlliaFGLYEWKGTKdgLLPPRLLFRGRNFALIL---IVAFVEGMIFYSLNIFWPQQISLLFTtdpLKAGLYQLPFGL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 316 ATMVMAPLAGYLIEK---VHAGLLGAMGLLIMACGLFGLallpSSPSDLDIIWRM-ALCGAGFGLFQSPNNHTIVSSAPG 391
Cdd:cd06179 310 GTLFGAILAGLLLTKikhIKWQLVAGFVLFTAFLALLAL----ITPDNKALAIAFsVLAGIGIGGPLVLAIVIVQLSVPP 385
|
410 420 430
....*....|....*....|....*....|
gi 505808183 392 HRSGGASGMLGTARLLGQSSGAALVALLFN 421
Cdd:cd06179 386 EDIGTASGLLGSARALGGAVGTAIFTSILS 415
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-456 |
1.14e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 87.63 E-value: 1.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 14 RYGAILTIVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTI 93
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 94 TSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLF 173
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 174 LINVPLGIISIFLAMRFLPpnssaskitrfDLPSAMMNALTFGLlitalggfaqgqSGYLVLAEVIAMLIIGFFFvrrql 253
Cdd:COG2223 163 LILGILLLVVAVLAWLFLR-----------DPPAGAAAAAKASL------------RDQLEALRDPRFWLLSLLY----- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 254 rmpvpllpvdllripifslsictsICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHA 333
Cdd:COG2223 215 ------------------------FGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 334 GLLGAMGLLIMACGLFGLALLPSSPSDLdiIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGA 413
Cdd:COG2223 271 RRVLLIVFALMALGLLLLALALGSLWLF--LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGP 348
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 505808183 414 ALVALLFNLAGNsgTHTALLLAGSLAVIAAAISGLRVTQPRAA 456
Cdd:COG2223 349 LLFGALLDATGS--YTAAFLVFAVLALVALVLTLLLYRRPRRA 389
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
38-419 |
7.93e-18 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 84.74 E-value: 7.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 38 ALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLG 117
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 118 GAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPNSSA 197
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 198 SKITRfdlpsAMMNALTFGLLITALGGFaqgqsGYlvlaeviaMLIIGFFFvrrqlrmpvpllpvdllripifslsicts 277
Cdd:TIGR00710 187 EARIQ-----ISTYFETFLLLLKSKMFW-----GY--------ALIYGASF----------------------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 278 icsfcAQMLAMVSL-PFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFGLAL--L 354
Cdd:TIGR00710 220 -----GGFFAFFSGaPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEItaI 294
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505808183 355 PSSPSDLDIIWRMALCGAGFGLFqSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALL 419
Cdd:TIGR00710 295 LGLGSWAMIIGPMMFVGIGNSMI-SSIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLI 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
34-445 |
1.23e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 81.10 E-value: 1.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 34 IANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVA 113
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 114 QGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPP 193
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 194 NSSASKITR--FDLPSAMMN-ALTFGLLITALGGFAQGqsgylvlaeviamlIIGFFfvrrqlrmpvpllpvdllrIPIF 270
Cdd:cd17489 174 PPVAAEEAEagTRAFRRLVEkKVLPPALILFLASIAYG--------------AISTF-------------------LPLY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 271 SLSictsicsfcaqmlamvslpfflqtvigRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFG 350
Cdd:cd17489 221 AAE---------------------------RGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 351 LALLPSSPSdldIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALLFNLAGNSGTHt 430
Cdd:cd17489 274 LSFAGSPWM---LLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF- 349
|
410
....*....|....*
gi 505808183 431 alLLAGSLAVIAAAI 445
Cdd:cd17489 350 --LLAAVVVLLALVL 362
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
38-214 |
5.58e-16 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 79.19 E-value: 5.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 38 ALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLG 117
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 118 GAALMSVNTALIRLIYPKRQLGRGMginSFVVAVSSAA---GPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPN 194
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMM---SFVTLVMTIApllAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPET 169
|
170 180
....*....|....*....|
gi 505808183 195 SSASKITRFDLPSAMMNALT 214
Cdd:PRK11102 170 LPKERRQPFHLRTTIRNFAS 189
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
32-255 |
1.88e-15 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 77.62 E-value: 1.88e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 32 GAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLAR 111
Cdd:cd17323 15 SSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 112 VAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFL 191
Cdd:cd17323 95 FLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFL 174
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 192 PPnssaskITRFDLPSAMMNALTFGLLIT------ALGGFAQGQSGYLVLAEVIAMlIIGFFFVRRQLRM 255
Cdd:cd17323 175 PI------VLLLGLYVGLVYAILYLFLTAfpyvfgEVYGFSPGEVGLMYLPIGIGA-LIGSIIGGRLSDY 237
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
55-193 |
7.98e-15 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 71.14 E-value: 7.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 55 WIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYP 134
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 505808183 135 KRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPP 193
Cdd:TIGR00880 82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
17-193 |
2.21e-14 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 74.22 E-value: 2.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 17 AILTIVLGLTMAVLDGAIanVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSL 96
Cdd:cd17476 1 ATISGAQLLNQAGLGSVI--VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 97 ICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLgrgmgiNSFVVAVSSAAGPT-------IAAAILSLASW 169
Cdd:cd17476 79 IAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPR------KNIVFSLFGATAPLgfalggvFGGLFAQLAWW 152
|
170 180
....*....|....*....|....*...
gi 505808183 170 QWLF----LINVPLGIISIFLAMRFLPP 193
Cdd:cd17476 153 PWIFwflaILAAIVAVAAIFWTSPSFIA 180
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-445 |
2.55e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 74.14 E-value: 2.55e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 14 RYGAILTIVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTI 93
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 94 TSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLF 173
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 174 LInvpLGIISIFLAMrflppnssaskITRFDLPSAMMNALTFGLLITALGGFaqgqsgylvlaeviamliigfffvrrql 253
Cdd:cd17319 161 II---EGLLGLLLAV-----------LWWFYLRQVWGLALGYFGINYALYGL---------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 254 rmpvpllpvdllripifslsictsicsfcaqmlaMVSLPFFLQTVIGRSEVETGLLLT-PWPLATMVMApLAGYLIEKVH 332
Cdd:cd17319 199 ----------------------------------LTWLPTYLKQARGFSLKQVGLLAAiPFLAGAIGMI-LGGRLSDRLL 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 333 AGLLGAMGLLIMACGLFGLALLPSSPSDLDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSG 412
Cdd:cd17319 244 RGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVA 323
|
410 420 430
....*....|....*....|....*....|...
gi 505808183 413 AALVALLFNLAGnsGTHTALLLAGSLAVIAAAI 445
Cdd:cd17319 324 PLLIGYLVDATG--SYTAAFLFLAAVALLAALL 354
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-446 |
6.16e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 72.84 E-value: 6.16e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 21 IVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICAL 100
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 101 SRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILS--LASWQWLFLINVP 178
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 179 LGIISIFLAMRFLPPNSSASKITRFDLPSAMmnaltfgllitalggfaqgqsgylvlaeviamliigfffvrrqlrmpVP 258
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKS-----------------------------------------------VL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 259 LLPVDLLRIPIFSLSICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGL-LG 337
Cdd:cd06174 194 KLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 338 AMGLLIMACGLFGLALLPSSPSdldIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVA 417
Cdd:cd06174 274 LIGLLLMALGLALLLLAPSLLL---LLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG 350
|
410 420
....*....|....*....|....*....
gi 505808183 418 LLFNLAGnsGTHTALLLAGSLAVIAAAIS 446
Cdd:cd06174 351 FLLAATF--GLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
34-446 |
1.39e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 62.63 E-value: 1.39e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 34 IANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTL---- 109
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLwlll 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 110 -ARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAM 188
Cdd:cd06173 97 vLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 189 rFLPPNSSASKITRFDLPsammnaltfgllitalggfaqgqsgylvlaevIAMLIIGFFFVRRQlrmpvpllpvdllriP 268
Cdd:cd06173 177 -FIRRPPPAAPGESSSLL--------------------------------LRDLREGLRYLRRS---------------P 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 269 IFSLSICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGL 348
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 349 FGLALLPSSPsdLDIIWrMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALLFNLAgnsGT 428
Cdd:cd06173 289 LVLGLSPSLW--LLLAA-LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL---GL 362
|
410
....*....|....*...
gi 505808183 429 HTALLLAGSLAVIAAAIS 446
Cdd:cd06173 363 SAVFLLAGALLLLAALLL 380
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-192 |
1.90e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.37 E-value: 1.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 18 ILTIVLGLTMAVLDG---AIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTIT 94
Cdd:TIGR00895 16 WRAIILSFLIMLMDGydlAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 95 SLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFL 174
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170
....*....|....*...
gi 505808183 175 INVPLGIISIFLAMRFLP 192
Cdd:TIGR00895 176 VGGIAPLLLLLLLMRFLP 193
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
23-201 |
2.78e-10 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 61.97 E-value: 2.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 23 LGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSR 102
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 103 SLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGII 182
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170
....*....|....*....
gi 505808183 183 SIFLAMRFLPPNSSASKIT 201
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWL 179
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
21-186 |
6.37e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 60.29 E-value: 6.37e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 21 IVLGLTMAVLDG---AIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLI 97
Cdd:cd17365 1 LALCFLIIVLDGfdlAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 98 CALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLIN- 176
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGg 160
|
170
....*....|
gi 505808183 177 VPLGIISIFL 186
Cdd:cd17365 161 VPPLILLPLL 170
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
17-448 |
7.07e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.56 E-value: 7.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 17 AILTIVLGLTMAVLDgaianVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSL 96
Cdd:COG0738 14 YLLFFLWGFATALWG-----PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 97 ICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQlGRGMGINSFVVAVSSAAGPTIAAAILSL---ASWQWLF 173
Cdd:COG0738 89 LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 174 LINVPLGIISIFLAMRFLPPNSSASKITRFDLPSAMMNALTFGLLitalggfaqgqsgylvlaevIAMLIIGFFFVrrql 253
Cdd:COG0738 168 LILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRL--------------------LLGGLAIFLYV---- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 254 rmpvpllpvdllripifslsictsicsfCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHA 333
Cdd:COG0738 224 ----------------------------GAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 334 GLLGAMGLLIMACGLFGLALLPSSPSdldIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTArllgqSSGA 413
Cdd:COG0738 276 VRLLRLSALLAAVGLLLALLAPGPWL---ALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-----IVGG 347
|
410 420 430
....*....|....*....|....*....|....*.
gi 505808183 414 ALVALLFN-LAGNSGTHTALLLAGSLAVIAAAISGL 448
Cdd:COG0738 348 AIGPPLIGfLADAFGLRAAFLVPLVCYLLILLLALA 383
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
69-194 |
4.67e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.91 E-value: 4.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 69 LPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGgaALMSVNTALIRLIYPKRQLGRGMGINSFV 148
Cdd:cd17472 50 IPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG--AISSVVMALLADLTREENRTKAMALIGAS 127
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 505808183 149 VAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPN 194
Cdd:cd17472 128 IGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDP 173
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-428 |
5.36e-08 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 54.69 E-value: 5.36e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 36 NVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQG 115
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 116 LGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILS-LASWQWLFLINVPLGIISIFLAMRFLPPN 194
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 195 SSASKITRFDL---PSAMMNALTFGLLITALGGFAQgqsgYLVLAEVIAMLIIGFFFVrrqlrmpvpllpvdllripIFS 271
Cdd:TIGR00881 175 PQSCGLPPAEEmpnEEPDGDAEKKEEELTKKQIFLQ----YVLLNKVLWYISLGYVFV-------------------YVV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 272 LSICTSIcsfcaqmlamvsLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMA---CGL 348
Cdd:TIGR00881 232 RTGILDW------------SPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMAliiVSL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 349 FGLALLPSSPSDLDIIWRMALCGAGFGlFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALLFNLAGNSGT 428
Cdd:TIGR00881 300 LVYWLNPAANPLMDLICLFALGFLVYG-PQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGA 378
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
30-193 |
1.45e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.39 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 30 LDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTL 109
Cdd:cd17328 13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 110 ARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSA----AGPTIAAAILslaSWQWLFLINVPLGIISIF 185
Cdd:cd17328 93 FRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGlgyvVGGLVAQATG---GWRWAFRVTGVLGVLLAI 169
|
....*...
gi 505808183 186 LAMRFLPP 193
Cdd:cd17328 170 LLLLFVRE 177
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
43-186 |
2.12e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.93 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 43 ATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALM 122
Cdd:cd17370 226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505808183 123 SVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFL 186
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-454 |
2.28e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.57 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 1 MEKKLLDGLPVPQRYGAILTIVLGLTMAVLDGAIANVA--LPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMV 78
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 79 GYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRqLGRGMGINSFVVAVSSAAGPT 158
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 159 IAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPNSSASKITrfdlpsammnaltfgllitalggfAQGQSGYLVLAEV 238
Cdd:COG2807 160 LTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAA------------------------PAAASLRSLWRSP 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 239 IAMLIIGFFFVrrqlrmpvpllpvdllripifslsictsicsFCAQMLAMVS-LPFFLQTvIGRSEVETGLLLTPWPLAT 317
Cdd:COG2807 216 LAWLLTLFFGL-------------------------------QSLLYYAVVAwLPPILRD-AGLSAATAGLLLSLFQLAG 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 318 MVMAPLAGYLIEKVHAglLGAMGLLIMACGLFGLALLPSSPSDLDIIWrMALCGAGFGLFQSPNNHTIVSSAPGHRSGGA 397
Cdd:COG2807 264 IPGSLLVPLLADRLGD--RRPLLLLLGLLGLAGLLGLLLAPGSLPWLW-AVLLGLGQGGLFPLALTLIGLRARTPAEAAA 340
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 505808183 398 -SGMLGTARLLGQSSGAALVALLFNLagnSGTHTALLLAGSLAVIAAAISGLRVTQPR 454
Cdd:COG2807 341 lSGMAQSVGYLLAALGPLLVGALHDA---TGSWTAALLLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
23-191 |
3.89e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.83 E-value: 3.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 23 LGLTMAVLDGAIANVALPTIATDLN--ASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICAL 100
Cdd:cd17316 6 LGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 101 SRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLAS----WQWLFLIN 176
Cdd:cd17316 86 LPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFLIG 165
|
170
....*....|....*
gi 505808183 177 VPLGIISIFLAMRFL 191
Cdd:cd17316 166 ALPALLALLLRRRTL 180
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
37-223 |
9.06e-07 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 50.79 E-value: 9.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 37 VALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGL 116
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 117 GGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPNSS 196
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETRP 183
|
170 180 190
....*....|....*....|....*....|..
gi 505808183 197 ASKITRFDLPSAMMNALTFG-----LLITALG 223
Cdd:PRK10473 184 ARAPAASSKPRENSESLLNRfflsrLVITTLS 215
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
38-192 |
1.01e-06 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 50.71 E-value: 1.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 38 ALPTIATDLNASPAssiWI---VNAYQI-AIVIALL--PLSflgDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLAR 111
Cdd:PRK15402 35 GMLAVVEDFNAGAE---WVptsMTAYLAgGMFLQWLlgPLS---DRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLR 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 112 VAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFL 191
Cdd:PRK15402 109 FLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAM 188
|
.
gi 505808183 192 P 192
Cdd:PRK15402 189 P 189
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
43-254 |
1.85e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 49.88 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 43 ATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALm 122
Cdd:cd17330 26 FNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 123 SVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPNSSASKITR 202
Cdd:cd17330 105 SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRLLLVYF 184
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 505808183 203 FDLPSAMMNALTFGLLITALGGFAQGQSGYLVLAEVIAMLIIGFFFVRRQLR 254
Cdd:cd17330 185 LIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAK 236
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
212-424 |
4.34e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 4.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 212 ALTFGLLITALGGfaQGQSGYLVLAEVIA-----MLIIGFFFVRRQLRMPVPLLPV-----DLLRIPIFSLSICTSICSF 281
Cdd:COG2211 164 SVLPPPLVAAFGG--DAALGYRLTALIFAvlgllAFLLTFFGTKERPVPEEEKVSLkeslkALLKNRPFLLLLLAYLLFF 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 282 CAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFGLALLPSSPSDL 361
Cdd:COG2211 242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWL 321
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 362 DIIWrMALCGAGFGLFQSPNNHTIVSSAP-------GHRSGGASGMLGTARLLGQSSGAALVALLFNLAG 424
Cdd:COG2211 322 LLVL-AALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
14-190 |
4.49e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 48.77 E-value: 4.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 14 RYGAILTIVLGLTMAVLDGAIANVALPTIATD-LNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFT 92
Cdd:cd06173 206 RSPLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 93 ITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWL 172
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAV 365
|
170
....*....|....*...
gi 505808183 173 FLINVPLGIISIFLAMRF 190
Cdd:cd06173 366 FLLAGALLLLAALLLLLL 383
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
38-192 |
6.67e-06 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 47.98 E-value: 6.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 38 ALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLG 117
Cdd:PRK11652 30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 505808183 118 GAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLP 192
Cdd:PRK11652 110 TGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMP 184
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
49-193 |
8.45e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.56 E-value: 8.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 49 SPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRR--IYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNT 126
Cdd:COG2271 214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505808183 127 ALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPP 193
Cdd:COG2271 294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
33-196 |
8.45e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 48.01 E-value: 8.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 33 AIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARV 112
Cdd:cd17327 23 NISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 113 AQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAIL------SLASWQWLFLINvplGIISIFL 186
Cdd:cd17327 103 FLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFkilgvgGLAGWRWLFIIE---GLITIII 179
|
170
....*....|...
gi 505808183 187 AM---RFLPPNSS 196
Cdd:cd17327 180 GLvifFWLPDNPS 192
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-248 |
9.77e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 47.55 E-value: 9.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 21 IVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICAL 100
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 101 SRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAIlSLASWQWLFLINV--P 178
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV-GTAGALPFLIAAVllL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 179 LGIISIFLAMRFLPPNSSASKITRFDL----PSAMMNALTFGLLITALG----------GFAQGQSGYLVLAEVIAMLII 244
Cdd:cd17477 160 LALVPLLLTRRAAPEIEEAESISLRRLlriaPLALLGAFVAGFLEGAFYsllplyglrlGLSVAQAALLLAAFVLGGLLL 239
|
....
gi 505808183 245 GFFF 248
Cdd:cd17477 240 QWPL 243
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
52-414 |
1.02e-05 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 47.69 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 52 SSIWIVNAYqIAIVIALlPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRL 131
Cdd:cd17322 40 STINVVNNI-VSAVSQP-PYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILAD 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 132 IYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQW---LFLINVPLGIISIFLAMRFLPPNSSASKITR------ 202
Cdd:cd17322 118 FSSLKNRGFASAIPSLPYIITTWIGGNIAQAALPNSNWRWgygMWAIILPLSSLPLVLCLLYMQRKARKDGEIKelknqe 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 203 ------------------FDLPSAMMNALTFGLL---ITALGGFAQGQSGYLVLAEVIAMLIIGFFFVRRQLRM-PVPLL 260
Cdd:cd17322 198 teeqtgglsqnlvklfwkLDIFGVILLTAGLGLIlvpLTLAGGAKSKWKNSSIIAMIVLGGVLLVAFLLWEAKFaKYPFL 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 261 PVDLLRIPIFSLSICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMG 340
Cdd:cd17322 278 PFRLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVII 357
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 505808183 341 LLIMACGLFGLALLPSSPSD--LDIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAA 414
Cdd:cd17322 358 GVPLYIVGMGLLIRYRGGSGshGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAA 433
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
23-192 |
1.56e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 46.91 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 23 LGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSR 102
Cdd:cd17371 6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 103 SLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLAS----WQWLFLINVP 178
Cdd:cd17371 86 NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLFLLGAL 165
|
170
....*....|....
gi 505808183 179 LGIISIFLAmRFLP 192
Cdd:cd17371 166 PALLVLFIR-RFVK 178
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
11-192 |
2.50e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 46.49 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 11 VPQRYGAILTIVLGLTMAVLDG---AIANVALPTIATDLNASPASSIWIVNAYqiaiVIALLPLSFLG----DMVGYRRI 83
Cdd:PRK11551 7 SASSSRLALTIGLCFLVALLEGldlQSAGVAAPRMAQEFGLDVAQMGWAFSAG----ILGLLPGALLGgrlaDRIGRKRI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 84 YKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAI 163
Cdd:PRK11551 83 LIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLA 162
|
170 180
....*....|....*....|....*....
gi 505808183 164 LSLASWQWLFLINVPLGIISIFLAMRFLP 192
Cdd:PRK11551 163 AGDAAWRHIFYVGGVGPLLLVPLLMRWLP 191
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
31-192 |
3.11e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 46.02 E-value: 3.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 31 DGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLA 110
Cdd:cd17359 16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 111 RVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVV--------AVSSAAGPTIAAAILSLASWQWLFLINVPLGII 182
Cdd:cd17359 96 RIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIvfgqllayIVNYLIANAGGADWLGAEGWRWMLGLEAIPAIL 175
|
170
....*....|
gi 505808183 183 sIFLAMRFLP 192
Cdd:cd17359 176 -FLLGMLFIP 184
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
46-167 |
4.01e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 4.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 46 LNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSR--SLEMLTLARVAQGLGGAALMS 123
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILV 338
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 505808183 124 VNTALI-------RLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLA 167
Cdd:COG2211 339 LPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
19-195 |
4.85e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 45.73 E-value: 4.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 19 LTIVLGLTMAVLDGAIANVALPTIA-----------TDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIG 87
Cdd:pfam00083 3 LVAALGGFLFGYDTGVIGAFLTLIDffknfglsksvSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 88 LVVFTITSLICALS---RSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAI- 163
Cdd:pfam00083 83 NVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLn 162
|
170 180 190
....*....|....*....|....*....|..
gi 505808183 164 LSLASWQWLFLINVPLGIISIFLAMRFLPPNS 195
Cdd:pfam00083 163 KTSNSDGWRIPLGLQLVPALLLIIGLLFLPES 194
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
291-456 |
5.25e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 45.31 E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 291 LPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFGLALLPSSPSDLDIiwrMALC 370
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVL---LFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 371 GAGFGLFQSPNNHTIVSSAPGHRSGGASGMlgtaRLLGQSSGAALVALLF-NLAGNSGTHTALLLAGSLAVIAAAISGLR 449
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGI----RQTGVPLGGALAAALLpPLALHYGWRAAFVVAGLVSILAAVLFWLF 170
|
....*..
gi 505808183 450 VTQPRAA 456
Cdd:cd17475 171 YREPPAA 177
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
78-190 |
8.46e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.48 E-value: 8.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 78 VGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLG-GAALMSVNTALIRLIyPKRQLGRGMGINSFVVAVSSAAG 156
Cdd:cd17474 262 FGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGlGLNLPLLTTLVTELA-PEEERGTASSLYNFVRFLGQAVG 340
|
90 100 110
....*....|....*....|....*....|....
gi 505808183 157 PTIAAAILSLASWQWLFLINVPLGIISIFLAMRF 190
Cdd:cd17474 341 PLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
36-443 |
8.65e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.57 E-value: 8.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 36 NVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQG 115
Cdd:cd17312 23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 116 LGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLInvplgiisiflamrflppns 195
Cdd:cd17312 103 LFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLV-------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 196 saskitrfdlPSAMMnaltfgllitalggfaqgqsgylvlaevIAMLIIGFFFVRRqlRMPVpllpVDLLRIPIFSLSIC 275
Cdd:cd17312 163 ----------PGIVG----------------------------LVVAIILFFFLRD--SPPY----VWVLSLAYAFVYIV 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 276 TSICSFCAqmlamvslPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFGLALLP 355
Cdd:cd17312 199 RYACLDWG--------PLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFW 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 356 SSPSDLDI-IWRMALCgaGFGLFQSPNNHTIVSSAPGHRS---GGASGMLGTARLLGQSSGAALVALLFNLAGNSGTHTA 431
Cdd:cd17312 271 FFPHNKLLsIVLLFLI--GFFVGGPINLIGGAAAQDIGRKeaaGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYF 348
|
410
....*....|..
gi 505808183 432 LLLAGSLAVIAA 443
Cdd:cd17312 349 LISAALLSVLLL 360
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
74-192 |
1.06e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 44.43 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 74 LGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSS 153
Cdd:PRK15403 74 LSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAP 153
|
90 100 110
....*....|....*....|....*....|....*....
gi 505808183 154 AAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLP 192
Cdd:PRK15403 154 IIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMP 192
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
74-191 |
1.07e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.18 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 74 LGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSS 153
Cdd:cd17391 263 LGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGN 342
|
90 100 110
....*....|....*....|....*....|....*...
gi 505808183 154 AAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFL 191
Cdd:cd17391 343 VAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
37-199 |
3.21e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.61 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 37 VALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGL 116
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 117 GGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFL--PPN 194
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYrePPA 176
|
....*
gi 505808183 195 SSASK 199
Cdd:cd17475 177 ASAAT 181
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
31-192 |
4.37e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.18 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 31 DGAIANVALPTIATDLNASPASSI--WIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLT 108
Cdd:cd17315 12 DLGVINGALLYIAKDLGFGLSTSLqgLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 109 LARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSF--VVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIIsIFL 186
Cdd:cd17315 92 VGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLmiTFGILLAYLLGLALSLSPPGWWRLMFALAAVPALL-QLL 170
|
....*.
gi 505808183 187 AMRFLP 192
Cdd:cd17315 171 LMFFLP 176
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-203 |
4.62e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.16 E-value: 4.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 37 VALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGL 116
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 117 GGAALMSVNTALIRLIYPKRQlGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPNSS 196
Cdd:cd17478 97 GSAAFHPEGARLASQAAGGRR-GLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
....*..
gi 505808183 197 ASKITRF 203
Cdd:cd17478 176 EAKKAAA 182
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
274-455 |
4.81e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 4.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 274 ICTSICSFCAQMLAMVSLPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFGLAL 353
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 354 LPSSPSdldIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALlfnLAGNSGTHTALL 433
Cdd:pfam07690 82 ASSLWL---LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL---LASLFGWRAAFL 155
|
170 180
....*....|....*....|..
gi 505808183 434 LAGSLAVIAAAISGLRVTQPRA 455
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPES 177
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
62-189 |
5.16e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 5.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 62 IAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRG 141
Cdd:cd17330 222 AGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKA 301
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 505808183 142 MGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMR 189
Cdd:cd17330 302 QGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
23-188 |
1.10e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.22 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 23 LGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSR 102
Cdd:PRK03893 27 LGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 103 SLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMG--INSFVVAVSSAAgpTIAAAILSLASWQWLFLInvplG 180
Cdd:PRK03893 107 GYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGflISGFSIGAVVAA--QVYSLVVPVWGWRALFFI----G 180
|
....*...
gi 505808183 181 IISIFLAM 188
Cdd:PRK03893 181 ILPIIFAL 188
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
12-177 |
1.20e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 41.27 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 12 PQRYGAILTIVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVF 91
Cdd:pfam05977 6 PLRQGVFRVIWIASLASNLGTLMQDVAASWLMTSLSASPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 92 TITSLICALSRSLEMLTLARV-----AQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSL 166
Cdd:pfam05977 86 ALVSTLLTLLAGLGLLSPWLLlgltfLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAA 165
|
170
....*....|.
gi 505808183 167 ASWQWLFLINV 177
Cdd:pfam05977 166 FGPAFTFALNA 176
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
78-196 |
1.22e-03 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 41.02 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 78 VGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPK-RQLGRGMGINSFVVAVSSAAG 156
Cdd:cd17384 58 IGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDdKERGKAMGIALGGLALGVLVG 137
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 505808183 157 PTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPNSS 196
Cdd:cd17384 138 PPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSVK 177
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-155 |
1.36e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 3 KKLLDGLPVPQRYGAILTIVLGLTMAVLDGAIANVALPTIATD-LNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYR 81
Cdd:COG2814 194 ARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 505808183 82 RIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAA 155
Cdd:COG2814 274 RLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
38-197 |
1.82e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 40.81 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 38 ALPTIATDLNASPASSIWiVNAYQIAIVIALLPLSFLGDMVGYRRI----YKIGLVVFTITSLICALSRSLEMLTLARVA 113
Cdd:pfam06609 66 ALPNILQDIGQSENQGLF-STLWTMGQAVSILMMGRLTDRFGRRPFviatHIIGLVGAIVGCTANKFNTLLAAMTLLGVA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 114 QGLGGAA------LMSVNTALIrliypkrqlgrGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLA 187
Cdd:pfam06609 145 AGPAGASplfigeLMSNKTKFL-----------GLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVLLI 213
|
170
....*....|
gi 505808183 188 MRFLPPNSSA 197
Cdd:pfam06609 214 IIWYHPPSFA 223
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
21-191 |
2.08e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.28 E-value: 2.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 21 IVLGLTMAVLDGAIanvalPTIATDLNASPASSIWIVNAYQI-AIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICA 99
Cdd:cd17490 205 LQQMITFSTTFGFT-----PLIAKQLGASSFQLGLLSIIYLLpNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIP 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 100 LSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPL 179
Cdd:cd17490 280 FAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVI 359
|
170
....*....|..
gi 505808183 180 GIISIFLAMRFL 191
Cdd:cd17490 360 ALLAAILSLAYY 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
266-456 |
2.72e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.96 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 266 RIPIFSLSICTSICSFCAQMLAMVSLPFfLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMA 345
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 346 CGLFGLALLPSSPSdldIIWRMALCGAGFGLFQSPNNHTIVSSAPGHRSGGASGMLGTARLLGQSSGAALVALlfnLAGN 425
Cdd:COG2814 87 LGSLLCALAPSLWL---LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL---LADL 160
|
170 180 190
....*....|....*....|....*....|.
gi 505808183 426 SGTHTALLLAGSLAVIAAAISGLRVTQPRAA 456
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPA 191
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
73-445 |
2.93e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 2.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 73 FLGDMVG-YRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAV 151
Cdd:cd17370 56 YLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 152 SSAAGPTIAAAILSLA--SWQWLFLINVPLGIISIF--LAMRFLPPNSSASKITRFDLPSAMMNAltfgllitalggfaq 227
Cdd:cd17370 136 GAVLGPLLAALLLYLLggNYRTIFLLAAIPALLALLilLFVVKEYPRPPKLRKKSKKTSLKKLPK--------------- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 228 gqsgylvlaEVIAMLIIGFFFvrrqlrmpvpllpvdllripifslsictsicsfcaqMLAMVSLPFFLQTV--IGRSEVE 305
Cdd:cd17370 201 ---------AFWLYLLAVALF------------------------------------ALGNFSFAFLILRAqeLGLSAAL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 306 TGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMGLLIMACGLFGLALLPSSPSdldIIWRMALCGAGFGLFQSPNNHTI 385
Cdd:cd17370 236 IPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWL---LLLGFILWGLYMGAQESIERAAV 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 386 VSSAPGHRSGGASGMLGTARLLGQSSGAALVALLFNLAgnsGTHTALLLAGSLAVIAAAI 445
Cdd:cd17370 313 ADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI---SPSAAFLFSAVLALIALLL 369
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
39-197 |
4.09e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.23 E-value: 4.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 39 LPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGG 118
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 119 AALMSVNTALIRLIYPKRQlGRGMGINSFVVAVSSAAGPTIAAAIL-SLASWQWLFLInvpLGIISIFLAMRFLPPNSSA 197
Cdd:cd17333 99 GILDTGANTFVGALFEESS-ATRLNVLHGFFGLGALIGPLIATSLLtSELSWSWAYLI---IGLIYLLLAILILLTLFPE 174
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
74-205 |
4.98e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 39.11 E-value: 4.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 74 LGDMVGYRRIYKIGLVVFTITSLICALSRSLEMLTLARVAQGLGGAALMSVNTALIRLIYPKRQLGRGMGINSFVVAVSS 153
Cdd:PRK11043 64 LSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSP 143
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 505808183 154 AAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPP----NSSASKITRFDL 205
Cdd:PRK11043 144 ALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSkkarKQSQDALTFKQL 199
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
33-402 |
5.15e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 38.82 E-value: 5.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 33 AIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSLICALS-RSLEMLTLAR 111
Cdd:TIGR00886 19 AFSPLAVFLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIR 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 112 VAQGLGGAALmSVNTALIRLIYPKRQLGRGMGINS----FVVAVSSAAGPTIAAAILSLA------SWQWLFLInVPLGI 181
Cdd:TIGR00886 99 LFIGIAGGSF-ASCMPWISFFFPKKIQGTALGLAAgwgnMGGGVAQFVMPPIIGSLIFGGgqpahlAWGWAFVI-VPAGI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 182 IsiflamrflppnssaskitrfdlpsammnALTFGLLITALGGFAQGQSGYLVLAEVIAMLIIGFffvrrqlrmpvpllp 261
Cdd:TIGR00886 177 L-----------------------------LLPALLIFFVGADTPPGKPATGKLSFKEALKVFGN--------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 262 vdlLRIPIFSLSICTSICSFcaqmLAMVS-LPFFLQTVIGRSEVETGLLLTPWPLATMVMAPLAGYLIEKVHAGLLGAMG 340
Cdd:TIGR00886 213 ---RHTWILALLYSVTFGSF----LGVSSiFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMN 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 505808183 341 LLIMACGLFGLALLPSSPSDLD-----IIWRMALCGAGFGLfqspnNHTIVSSAPGHRSGGASGMLG 402
Cdd:TIGR00886 286 FLGVAMGAFLVVLGLVSDGSLAafivlFVALFFFAGAGNGS-----TFALVPHIFRRATGAVSGLIG 347
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
17-192 |
6.18e-03 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 38.74 E-value: 6.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 17 AILTIVLGLTMAVLDGAIANVALPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIYKIGLVVFTITSL 96
Cdd:cd17332 222 PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLL 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 97 ICAL--SRSLEMLTLARVAQGLGGAALMSVNTALI-------RLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLA 167
Cdd:cd17332 302 LLFFlpPGNLVLILVLAVLAGIGYGGANLLPWAMLadvidygELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLA 381
|
170 180
....*....|....*....|....*
gi 505808183 168 SWQWLFLINVPLGIISIFLAMRFLP 192
Cdd:cd17332 382 GYVANAAAQSASALNGIRLLIAVLP 406
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
39-201 |
7.75e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.36 E-value: 7.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 39 LPTIATDLNASPASSIWIVNAYQIAIVIALLPLSFLGDMVGYRRIY-KIGLVVFTITSLICALSRSLEMLTLARVAQGLG 117
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFiIIGLLFTVLASLIMILFPSPWGLLIARFLSGIA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 505808183 118 GAALMSVnTALIRLIYPKRQLGRGMGINSFVVAVSSAAGPTIAAAILSLASWQWLFLINVPLGIISIFLAMRFLPPNSSA 197
Cdd:cd17490 99 AATWVSF-TVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREK 177
|
....
gi 505808183 198 SKIT 201
Cdd:cd17490 178 KPVL 181
|
|
| |
