Conserved domains on
[gi|506292893|ref|WP_015812668|]
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alpha-2-macroglobulin [Dyadobacter fermentans]
Protein Classification
alpha-2-macroglobulin family protein( domain architecture ID 11457182)
immunoglobulin (Ig)-like domain-containing alpha-2-macroglobulin family protein may be a broad-spectrum protease inhibitor, similar to alpha-2-macroglobulin from Escherichia coli (A2MG, YfhM) and similar proteins from proteobacteria
CATH: 2.60.40.10
SCOP: 2000051
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||||||||||||||||||||
| YfaS | COG2373 | Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
226-2020 | 0e+00 | ||||||||||||||||||||||||
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]; : Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 717.63 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||||||||||||||||||||
| YfaS | COG2373 | Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
226-2020 | 0e+00 | ||||||||||||||||||||||||
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]; Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 717.63 E-value: 0e+00
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| bMG10 | pfam17973 | Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
1885-2009 | 1.91e-40 | ||||||||||||||||||||||||
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9. Pssm-ID: 465598 Cd Length: 128 Bit Score: 146.29 E-value: 1.91e-40
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| A2M_like | cd02891 | Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1467-1796 | 1.45e-04 | ||||||||||||||||||||||||
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond. Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 45.84 E-value: 1.45e-04
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| Name | Accession | Description | Interval | E-value | ||||||||||||||||||||||||
| YfaS | COG2373 | Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
226-2020 | 0e+00 | ||||||||||||||||||||||||
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only]; Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 717.63 E-value: 0e+00
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| bMG10 | pfam17973 | Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
1885-2009 | 1.91e-40 | ||||||||||||||||||||||||
Bacterial Alpha-2-macroglobulin MG10 domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. Bacterial A2Ms are located in the periplasm where they are believed to provide protection to the cell by trapping external proteases through a covalent interaction with an activated thioester. This domain is found on the C-terminal region in A2Ms in bacteria. Structure analysis of Salmonella enterica ser A2Ms (SA-A2Ms) show that they are composed of 13 domains, all of which fold as variants of beta sandwiches with the exception of the TED, which consists of 14 alpha helices. Most of the beta sandwich domains appear to serve a structural role and are referred to as the macroglobulin-like (MG) domains. This is the MG10 domain. MG10 is markedly different from the other MG domains in that it has more beta strands and an alpha helix. The position of MG10 is stabilized by, in addition to other hydrogen bonds, the formation of a beta sheet with MG9. Pssm-ID: 465598 Cd Length: 128 Bit Score: 146.29 E-value: 1.91e-40
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| A2M | pfam00207 | Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
1252-1342 | 3.05e-23 | ||||||||||||||||||||||||
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family. Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 95.73 E-value: 3.05e-23
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| MG2 | pfam01835 | MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
600-690 | 8.65e-16 | ||||||||||||||||||||||||
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4. Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 74.66 E-value: 8.65e-16
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| A2M_like | cd02891 | Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
1467-1796 | 1.45e-04 | ||||||||||||||||||||||||
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond. Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 45.84 E-value: 1.45e-04
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| bMG3 | pfam11974 | Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial ... |
491-576 | 2.47e-04 | ||||||||||||||||||||||||
Bacterial alpha-2-macroglobulin MG3 domain; This is the MG3 domain from bacterial alpha2-macroglobulins. Pssm-ID: 432232 [Multi-domain] Cd Length: 102 Bit Score: 42.20 E-value: 2.47e-04
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| CarboxypepD_reg | pfam13620 | Carboxypeptidase regulatory-like domain; |
509-580 | 5.82e-04 | ||||||||||||||||||||||||
Carboxypeptidase regulatory-like domain; Pssm-ID: 433354 [Multi-domain] Cd Length: 81 Bit Score: 40.34 E-value: 5.82e-04
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