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Conserved domains on  [gi|506314133|ref|WP_015833908|]
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MULTISPECIES: MdtB/MuxB family multidrug efflux RND transporter permease subunit [Photorhabdus]

Protein Classification

multidrug transporter subunit MdtB( domain architecture ID 11484747)

multidrug transporter subunit MdtB is a component of the MdtABC tripartite complex that confers resistance against novobiocin and deoxycholate; MdtABC requires TolC for its function

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
1-1040 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


:

Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 1961.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    1 MQVSAQIPGGGPSRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQL 80
Cdd:PRK10503    1 MQVLPPSSTGGPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   81 GQMSGLKQMASQSSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIYNKVNPADPPILTLAVTSDAMPM 160
Cdd:PRK10503   81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  161 TQIQDMVETRVAQKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSA 240
Cdd:PRK10503  161 TQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  241 NDQMKSVDDYRKLIIAYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSL 320
Cdd:PRK10503  241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  321 PKSVDIKILTDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMA 400
Cdd:PRK10503  321 PKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMA 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  401 LTIATGFVVDDAIVVIENISRYIEQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAI 480
Cdd:PRK10503  401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  481 LISAVVSLTLTPMMCARMLKSESQVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKG 560
Cdd:PRK10503  481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKG 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  561 FFPLQDNGLIQGTLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGVDGSNPTLNNGRLQITLKPINQRNDRIAEI 640
Cdd:PRK10503  561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  641 IPRLQGKMASIPDVKLYLQPMQDLTIDTQVTRNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYI 720
Cdd:PRK10503  641 IARLQTAVAKVPGVDLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYV 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  721 KVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQ 800
Cdd:PRK10503  721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQ 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  801 RFGPLAINHLAQFPATTFSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIV 880
Cdd:PRK10503  801 RFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  881 LGILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLPPYEAIYQA 960
Cdd:PRK10503  881 LGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA 960
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  961 CLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDKLARYRRNRKPGELDNS 1040
Cdd:PRK10503  961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEEA 1040
 
Name Accession Description Interval E-value
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
1-1040 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 1961.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    1 MQVSAQIPGGGPSRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQL 80
Cdd:PRK10503    1 MQVLPPSSTGGPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   81 GQMSGLKQMASQSSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIYNKVNPADPPILTLAVTSDAMPM 160
Cdd:PRK10503   81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  161 TQIQDMVETRVAQKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSA 240
Cdd:PRK10503  161 TQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  241 NDQMKSVDDYRKLIIAYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSL 320
Cdd:PRK10503  241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  321 PKSVDIKILTDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMA 400
Cdd:PRK10503  321 PKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMA 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  401 LTIATGFVVDDAIVVIENISRYIEQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAI 480
Cdd:PRK10503  401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  481 LISAVVSLTLTPMMCARMLKSESQVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKG 560
Cdd:PRK10503  481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKG 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  561 FFPLQDNGLIQGTLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGVDGSNPTLNNGRLQITLKPINQRNDRIAEI 640
Cdd:PRK10503  561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  641 IPRLQGKMASIPDVKLYLQPMQDLTIDTQVTRNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYI 720
Cdd:PRK10503  641 IARLQTAVAKVPGVDLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYV 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  721 KVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQ 800
Cdd:PRK10503  721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQ 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  801 RFGPLAINHLAQFPATTFSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIV 880
Cdd:PRK10503  801 RFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  881 LGILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLPPYEAIYQA 960
Cdd:PRK10503  881 LGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA 960
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  961 CLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDKLARYRRNRKPGELDNS 1040
Cdd:PRK10503  961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEEA 1040
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
13-1024 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1308.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   13 SRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQ 92
Cdd:NF033617    1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIYNKVNPADPPILTLAVTSDAMPMTQIQDMVETRVA 172
Cdd:NF033617   81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  173 QKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDDYRK 252
Cdd:NF033617  161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  253 LIIAYK-NGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKILTD 331
Cdd:NF033617  241 LVIKYAdNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  332 RTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDD 411
Cdd:NF033617  321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  412 AIVVIENISRYIEQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISAVVSLTLT 491
Cdd:NF033617  401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  492 PMMCARMLKSEsqVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKGFFPLQDNGLIQ 571
Cdd:NF033617  481 PMMCSRLLKAN--EKPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVIF 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  572 GTLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGVdGSNPTLNNGRLQITLKPINQRNDRIAEIIPRLQGKMASI 651
Cdd:NF033617  559 GMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGV-GGNPGDNTGFGIINLKPWDERDVSAQEIIDRLRPKLAKV 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  652 PDVKLYLQPMQDLTIDTQVTRNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYIKVDRDIASRLG 731
Cdd:NF033617  638 PGMDLFLFPLQDLPGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLG 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  732 ISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQRFGPLAINHLA 811
Cdd:NF033617  718 ISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFN 797
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  812 QFPATTFSFNVSGNASLEQSVNAVRNAAQLIeMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIVLGILYESFIHP 891
Cdd:NF033617  798 QFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDP 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  892 VTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLPPYEAIYQACLLRFRPILMT 971
Cdd:NF033617  877 LTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMT 956
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|...
gi 506314133  972 TMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDK 1024
Cdd:NF033617  957 TLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
13-1029 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1107.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   13 SRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQ 92
Cdd:COG0841     4 SRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITST 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLpYPPIYNKVNPADPPILTLAVTSDAMPMTQIQDMVETRVA 172
Cdd:COG0841    84 SSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDV-EPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERNIK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  173 QKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDDYRK 252
Cdd:COG0841   163 DRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFEN 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  253 LIIAYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKILTDR 332
Cdd:COG0841   243 IVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVYDQ 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  333 TTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDDA 412
Cdd:COG0841   323 SEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDA 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  413 IVVIENISRYIEQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISAVVSLTLTP 492
Cdd:COG0841   403 IVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTLTP 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  493 MMCARMLKSESQVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKGFFPLQDNGLIQG 572
Cdd:COG0841   483 ALCARLLKPHPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIV 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  573 TLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGVDGSNPTLNNGRLQITLKPINQRNDRIAEIIPRLQGKMASIP 652
Cdd:COG0841   563 SVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSNSGTIFVTLKPWDERDRSADEIIARLREKLAKIP 642
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  653 DVKLYLQPMQDltiDTQVTRNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYIKVDRDIASRLGI 732
Cdd:COG0841   643 GARVFVFQPPA---GGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAALGV 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  733 SMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQRFGPLAINHLAQ 812
Cdd:COG0841   720 TVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINRYNG 799
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  813 FPATTFSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIVLGILYESFIHPV 892
Cdd:COG0841   800 QRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPL 879
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  893 TILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALaAEREQGLPPYEAIYQACLLRFRPILMTT 972
Cdd:COG0841   880 IILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFAN-QLREEGMSLREAILEAARLRLRPILMTS 958
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 506314133  973 MAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDKLARYR 1029
Cdd:COG0841   959 LATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRRL 1015
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
12-1023 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1072.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    12 PSRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMAS 91
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    92 QSSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLpYPPIYNKVNPADPPILTLAVTSD--AMPMTQIQDMVET 169
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGV-QRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   170 RVAQKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDD 249
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   250 YRKLIIAYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKIL 329
Cdd:pfam00873  240 FEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   330 TDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVV 409
Cdd:pfam00873  320 YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   410 DDAIVVIENISRYI-EQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISAVVSL 488
Cdd:pfam00873  400 DDAIVVVENIERVLeENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   489 TLTPMMCARMLKSESQVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKGFFPLQDNG 568
Cdd:pfam00873  480 TLTPALCATLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   569 LIQGTLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGV--DGSNPTLNNGRLQITLKPINQR---NDRIAEIIPR 643
Cdd:pfam00873  560 VFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFafSGDNNGPNSGDAFISLKPWKERpgpEKSVQALIER 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   644 LQGKMASIPDVKLYLQPMQDLTIDTQVT--RNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYIK 721
Cdd:pfam00873  640 LRKALKQIPGANVFLFQPIQLRGLGTISgfRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVN 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   722 VDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQR 801
Cdd:pfam00873  720 IDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   802 FGPLAINHLAQFPATTFSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIVL 881
Cdd:pfam00873  800 YGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   882 GILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLPPYEAIYQAC 961
Cdd:pfam00873  880 AALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEAC 959
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506314133   962 LLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFD 1023
Cdd:pfam00873  960 RLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
13-1025 6.71e-167

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 518.13  E-value: 6.71e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    13 SRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQ 92
Cdd:TIGR00915    2 AKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSS 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    93 SSG-GASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIynKVNPA-DPPILTLAVTSDAMPMTQ--IQDMVE 168
Cdd:TIGR00915   82 SDSdGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGV--RVEKAsSNFLMVIGLVSDDGSMTKedLSDYAA 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   169 TRVAQKISQVNGVGLVTLAGGQRpAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSL------DGPTRSVTLSAND 242
Cdd:TIGR00915  160 SNMVDPLSRLEGVGDVQLFGSQY-AMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglpavPGQQLNATIIAQT 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   243 QMKSVDDYRKLII-AYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLP 321
Cdd:TIGR00915  239 RLQTPEQFENILLkVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   322 KSVDIKILTDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMAL 401
Cdd:TIGR00915  319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   402 TIATGFVVDDAIVVIENISRYI-EQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAI 480
Cdd:TIGR00915  399 VLAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   481 LISAVVSLTLTPMMCARMLKSESQVKHNrfEQASEHF------FKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLY 554
Cdd:TIGR00915  479 ALSVLVALILTPALCATMLKPIEKGEHH--EKKGGFFgwfnrmFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLF 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   555 IIIPKGFFPLQDNGLIQGTLEAPQSISFSAMADKQRQVSSLLLQDPA--VENVTTFVGVDGSNPTLNNGRLQITLKPINQ 632
Cdd:TIGR00915  557 VRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKanVESVFTVNGFSFAGRGQNMGMAFIRLKDWEE 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   633 R---NDRIAEIIPRLQGKMASIPD---VKLYLQPMQDLTidtqvTRNQYQFTLQA---TSLDELSIWVPKLLAELKQRSE 703
Cdd:TIGR00915  637 RtgkENSVFAIAGRATGHFMQIKDamvIAFVPPAILELG-----NATGFDFFLQDragLGHEALLQARNQLLGLAAQNPA 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   704 LVDISSDWQARGLIAYIKVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLN 783
Cdd:TIGR00915  712 LTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVR 791
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   784 GTDGNIVPLSTIATVEQRFGPLAINHLAQFPATTFSFNVSGNASLEQSVNAVRNAAQliEMPKDmtIKFQGTTLAFESAL 863
Cdd:TIGR00915  792 NASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQ--KLPPG--FGFSWTGMSYEERL 867
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   864 --GNTLWLIAAAVTAMYIVLGILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDF 941
Cdd:TIGR00915  868 sgSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEF 947
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   942 AlAAEREQGLPPYEAIYQACLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLL 1021
Cdd:TIGR00915  948 A-KELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVV 1026

                   ....
gi 506314133  1022 FDKL 1025
Cdd:TIGR00915 1027 VRRL 1030
 
Name Accession Description Interval E-value
PRK10503 PRK10503
MdtB/MuxB family multidrug efflux RND transporter permease subunit;
1-1040 0e+00

MdtB/MuxB family multidrug efflux RND transporter permease subunit;


Pssm-ID: 182501 [Multi-domain]  Cd Length: 1040  Bit Score: 1961.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    1 MQVSAQIPGGGPSRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQL 80
Cdd:PRK10503    1 MQVLPPSSTGGPSRLFILRPVATTLLMVAILLAGIIGYRALPVSALPEVDYPTIQVVTLYPGASPDVMTSAVTAPLERQF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   81 GQMSGLKQMASQSSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIYNKVNPADPPILTLAVTSDAMPM 160
Cdd:PRK10503   81 GQMSGLKQMSSQSSGGASVITLQFQLTLPLDVAEQEVQAAINAATNLLPSDLPNPPVYSKVNPADPPIMTLAVTSTAMPM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  161 TQIQDMVETRVAQKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSA 240
Cdd:PRK10503  161 TQVEDMVETRVAQKISQVSGVGLVTLSGGQRPAVRVKLNAQAIAALGLTSETVRTAITGANVNSAKGSLDGPTRAVTLSA 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  241 NDQMKSVDDYRKLIIAYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSL 320
Cdd:PRK10503  241 NDQMQSAEEYRQLIIAYQNGAPIRLGDVATVEQGAENSWLGAWANKQQAIVMNVQRQPGANIIATADSIRQMLPQLTESL 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  321 PKSVDIKILTDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMA 400
Cdd:PRK10503  321 PKSVKVTVLSDRTTNIRASVDDTQFELMLAIALVVMIIYLFLRNIPATIIPGVAVPLSLIGTFAVMVFLDFSINNLTLMA 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  401 LTIATGFVVDDAIVVIENISRYIEQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAI 480
Cdd:PRK10503  401 LTIATGFVVDDAIVVIENISRYIEKGEKPLAAALKGAGEIGFTIISLTFSLIAVLIPLLFMGDIVGRLFREFAVTLAVAI 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  481 LISAVVSLTLTPMMCARMLKSESQVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKG 560
Cdd:PRK10503  481 LISAVVSLTLTPMMCARMLSQESLRKQNRFSRASERMFDRVIAAYGRGLAKVLNHPWLTLSVALSTLLLTVLLWIFIPKG 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  561 FFPLQDNGLIQGTLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGVDGSNPTLNNGRLQITLKPINQRNDRIAEI 640
Cdd:PRK10503  561 FFPVQDNGIIQGTLQAPQSSSFANMAQRQRQVADVILQDPAVQSLTSFVGVDGTNPSLNSARLQINLKPLDERDDRVQKV 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  641 IPRLQGKMASIPDVKLYLQPMQDLTIDTQVTRNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYI 720
Cdd:PRK10503  641 IARLQTAVAKVPGVDLYLQPTQDLTIDTQVSRTQYQFTLQATSLDALSTWVPKLMEKLQQLPQLSDVSSDWQDKGLVAYV 720
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  721 KVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQ 800
Cdd:PRK10503  721 NVDRDSASRLGISMADVDNALYNAFGQRLISTIYTQANQYRVVLEHNTENTPGLAALDTIRLTSSDGGVVPLSSIATIEQ 800
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  801 RFGPLAINHLAQFPATTFSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIV 880
Cdd:PRK10503  801 RFGPLSINHLDQFPSTTISFNVPDGYSLGDAVQAIMDTEKTLNLPADITTQFQGSTLAFQSALGSTVWLIVAAVVAMYIV 880
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  881 LGILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLPPYEAIYQA 960
Cdd:PRK10503  881 LGVLYESFIHPITILSTLPTAGVGALLALMIAGSELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGMSPRDAIYQA 960
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  961 CLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDKLARYRRNRKPGELDNS 1040
Cdd:PRK10503  961 CLLRFRPILMTTLAALLGALPLMLSTGVGAELRRPLGICMVGGLIVSQVLTLFTTPVIYLLFDRLALYTKSRFPRHEEEA 1040
RND_permease_2 NF033617
multidrug efflux RND transporter permease subunit;
13-1024 0e+00

multidrug efflux RND transporter permease subunit;


Pssm-ID: 411236 [Multi-domain]  Cd Length: 1009  Bit Score: 1308.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   13 SRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQ 92
Cdd:NF033617    1 SDVFIKRPVATLLLSLLILLLGLLAFRKLPVREYPEVDFPTITVSTSYPGASPELMQSSITQPLEQQLAQIEGIDEMTSQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIYNKVNPADPPILTLAVTSDAMPMTQIQDMVETRVA 172
Cdd:NF033617   81 SSLGYSTITLQFRLGTDLDVALSEVQAAINAAQSLLPSEAPDPPVYRKANSADTPIMYIGLTSEEMPRGQLTDYAERVLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  173 QKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDDYRK 252
Cdd:NF033617  161 PKLSQINGVGSVDVSGGQRPAMRVWLDPEKMAARGLTADDVRSALNSNNVNSPKGAVRGDSVVSTVRANDQLKTAEDYED 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  253 LIIAYK-NGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKILTD 331
Cdd:NF033617  241 LVIKYAdNGAPVRLGDVATVELGAENVRNRAWANGVPAVVLGINRQPGANPIEVADEIRALLPELQETLPKNIKVNVLYD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  332 RTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDD 411
Cdd:NF033617  321 RTRFIRASIDEVESTLLEAVALVILVVFLFLRNLRATLIPAVTVPLSLIGTFAVMYLFGFSINLLTLMALVLAIGLVVDD 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  412 AIVVIENISRYIEQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISAVVSLTLT 491
Cdd:NF033617  401 AIVVVENIHRHIEEGESPLEAALKGAREIGFTVIAMTLTLVAVYLPILFMGGLTGRLFREFAVTLAGAVIISGIVALTLT 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  492 PMMCARMLKSEsqVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKGFFPLQDNGLIQ 571
Cdd:NF033617  481 PMMCSRLLKAN--EKPGRFARAVDRFFDGLTARYGRGLKWVLKHRPLTLVVALATLALLPLLYVFIPKELAPSEDRGVIF 558
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  572 GTLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGVdGSNPTLNNGRLQITLKPINQRNDRIAEIIPRLQGKMASI 651
Cdd:NF033617  559 GMIQAPQSISLDYMSAKMRDVEKILSSDPEVQSLTSFNGV-GGNPGDNTGFGIINLKPWDERDVSAQEIIDRLRPKLAKV 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  652 PDVKLYLQPMQDLTIDTQVTRNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYIKVDRDIASRLG 731
Cdd:NF033617  638 PGMDLFLFPLQDLPGGAGSSLPQYQVTLTPSDYDSLFTWAEKLKEKLRKSPQFADVDSDLQDKGPELNVDIDRDKAARLG 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  732 ISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQRFGPLAINHLA 811
Cdd:NF033617  718 ISMQDIGSTLEVAFGQRQVNTIYTDGNQYKVVLEVDRRYRLNPEALNQIYVRSNDGKLVPLSTLAKIEERAAPLSLNHFN 797
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  812 QFPATTFSFNVSGNASLEQSVNAVRNAAQLIeMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIVLGILYESFIHP 891
Cdd:NF033617  798 QFNSATLSFNLAPGVSLGEAIEALDQAAKEL-LPSGISGSFQGAARAFQEEGSSLLFLFLLALAAIYLVLAIQYESFVDP 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  892 VTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLPPYEAIYQACLLRFRPILMT 971
Cdd:NF033617  877 LTILSTVPLAGCGALLALALGGQSMNIYAQIGLITLIGLVKKNGILMVEFANELQRHQGLSRREAIYQAAALRLRPILMT 956
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|...
gi 506314133  972 TMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDK 1024
Cdd:NF033617  957 TLAMLLGAIPLMLSTGAGAESRFPLGIVIVGGLGVGTLFTLFVLPVVYLLLAR 1009
AcrB COG0841
Multidrug efflux pump subunit AcrB [Defense mechanisms];
13-1029 0e+00

Multidrug efflux pump subunit AcrB [Defense mechanisms];


Pssm-ID: 440603 [Multi-domain]  Cd Length: 1015  Bit Score: 1107.48  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   13 SRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQ 92
Cdd:COG0841     4 SRFFIRRPVAAIVLSLLILLAGLLAYLRLPVEQFPDIDPPTVTVSTTYPGASPEEVESTVTTPIEEALNGVEGIKYITST 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLpYPPIYNKVNPADPPILTLAVTSDAMPMTQIQDMVETRVA 172
Cdd:COG0841    84 SSEGSSSITVEFELGTDIDEALVDVQNAVDRARSDLPEDV-EPPGVTKVNPSDFPVMVLALSSDDLDELELSDYAERNIK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  173 QKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDDYRK 252
Cdd:COG0841   163 DRLERVPGVGQVQIFGGREREIRIWLDPDKLAAYGLTLADVANAIRAQNVDVPAGRIGGGDREYTVRTNGRLKTPEEFEN 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  253 LIIAYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKILTDR 332
Cdd:COG0841   243 IVIRTNDGSVVRLGDVARVEDGAEDYRSIARLNGKPAVGLAIQKQPGANALEVADAVRAKLEELQASLPEGVELTIVYDQ 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  333 TTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDDA 412
Cdd:COG0841   323 SEFIRASIEEVVKTLLEAILLVVLVVFLFLRSWRATLIPAVAIPVSLIGTFAVMYLLGFSLNILTLFALVLAIGIVVDDA 402
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  413 IVVIENISRYIEQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISAVVSLTLTP 492
Cdd:COG0841   403 IVVVENIERHMEEGLSPLEAAIKGAREVAGAVIASTLTLVAVFLPLAFMGGITGQLFRQFALTVAIALLISLFVALTLTP 482
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  493 MMCARMLKSESQVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKGFFPLQDNGLIQG 572
Cdd:COG0841   483 ALCARLLKPHPKGKKGRFFRAFNRGFDRLTRGYGRLLRWALRHRKLTLLVALALLALSVLLFGRLPTEFFPEEDQGQIIV 562
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  573 TLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGVDGSNPTLNNGRLQITLKPINQRNDRIAEIIPRLQGKMASIP 652
Cdd:COG0841   563 SVQLPPGTSLERTEAVVRQVEEILLEVPEVESVFSVVGFSGGGSGSNSGTIFVTLKPWDERDRSADEIIARLREKLAKIP 642
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  653 DVKLYLQPMQDltiDTQVTRNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYIKVDRDIASRLGI 732
Cdd:COG0841   643 GARVFVFQPPA---GGLGSGAPIEVQLQGDDLEELAAAAEKLLAALRQIPGLVDVRSDLQLGKPELQLDIDREKAAALGV 719
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  733 SMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQRFGPLAINHLAQ 812
Cdd:COG0841   720 TVADVASTLRAALGGRYVNDFNRGGREYDVRVQAPEEDRNSPEDLENLYVRTPDGEMVPLSSVATIEEGTGPSSINRYNG 799
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  813 FPATTFSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIVLGILYESFIHPV 892
Cdd:COG0841   800 QRSVTVSANLAPGVSLGEALAAIEELAAELKLPPGVSIEFTGQAEEEQESFSSLGLAFLLALLLVYLVLAAQFESFIQPL 879
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  893 TILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALaAEREQGLPPYEAIYQACLLRFRPILMTT 972
Cdd:COG0841   880 IILLTVPLALIGALLGLLLTGTPLNIYSQIGLIMLIGIVVKNAILLVDFAN-QLREEGMSLREAILEAARLRLRPILMTS 958
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 506314133  973 MAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDKLARYR 1029
Cdd:COG0841   959 LATILGLLPLALGTGAGAEFRQPLGIAVIGGLLFSTLLTLFVVPVLYVLLDRLRRRL 1015
ACR_tran pfam00873
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ...
12-1023 0e+00

AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.


Pssm-ID: 395701 [Multi-domain]  Cd Length: 1021  Bit Score: 1072.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    12 PSRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMAS 91
Cdd:pfam00873    1 MSKFFIRRPIFTLVLAIAILLAGILSFFSLPVDAFPEIAPPTVQVSTSYPGASPEEVEDTVTQPIEQAMNGLDGLKYMSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    92 QSSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLpYPPIYNKVNPADPPILTLAVTSD--AMPMTQIQDMVET 169
Cdd:pfam00873   81 QSSYGLSSITLTFELGTDIDIARQDVQNRLQLATPLLPEGV-QRPGISVIKTSLGPIMVLAVTSPdgSYTQTDLRDYADT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   170 RVAQKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDD 249
Cdd:pfam00873  160 NIKPQLSRVPGVGDVQLFGGSEYAMRIWLDPQKLARYGLTLTDVVSALKEQNVNIGAGQLEGQGLQALIRAQGQLQSAED 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   250 YRKLIIAYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKIL 329
Cdd:pfam00873  240 FEKIIVKNQDGSPVRLRDVATVELGSELYRGFATFNGKPAVGLGVQKLPGANAIETADAVRAKLAELKPTFPQGVEIVVV 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   330 TDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVV 409
Cdd:pfam00873  320 YDTTPFIRASIEEVVKTLLEAIVLVILVMFLFLQNWRATLIPAIAIPLSLLGTFAVMKAFGFSINTLTLGGLVLAIGLVV 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   410 DDAIVVIENISRYI-EQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISAVVSL 488
Cdd:pfam00873  400 DDAIVVVENIERVLeENGLKPLEAAYKSMGEIGGALVAIALVLSAVFLPILFLGGLTGRIFRQFAITIVLAILLSVLVAL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   489 TLTPMMCARMLKSESQVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKGFFPLQDNG 568
Cdd:pfam00873  480 TLTPALCATLLKPRREPKHGGFFRWFNRMFDRLTRGYAKLLAKVLRHTAVVLLVALLLVVGSVWLFVRIPTEFLPEEDEG 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   569 LIQGTLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGV--DGSNPTLNNGRLQITLKPINQR---NDRIAEIIPR 643
Cdd:pfam00873  560 VFVTSAQLPPGVSLDQTQRVMKQVEKILKEKPEVESVFAVTGFafSGDNNGPNSGDAFISLKPWKERpgpEKSVQALIER 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   644 LQGKMASIPDVKLYLQPMQDLTIDTQVT--RNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYIK 721
Cdd:pfam00873  640 LRKALKQIPGANVFLFQPIQLRGLGTISgfRSDLQVKIFGDDLDALDEARNQILAALAQLPGLSDVRSDGQEDQPQLQVN 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   722 VDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQR 801
Cdd:pfam00873  720 IDREKAARLGVSIQDINDTLSTALGGSYVNDFPEGGRVYDVVVQLPEDFRSSPEDIGQLYVRNPYGKMIPLSAFAKIEWG 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   802 FGPLAINHLAQFPATTFSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIVL 881
Cdd:pfam00873  800 YGPPSINRYNGFRSIVISGNVAAGDSLGDAMEAMAQIAKQVKLPPGYGYTWTGQFEQEQLAGNSLPILIALALLVVFLVL 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   882 GILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLPPYEAIYQAC 961
Cdd:pfam00873  880 AALYESWSDPLSIMLTVPLALVGALLALWLRGLPNSVYAQVGLILLIGLAVKNAILMVEFANELREQEGKSLEEAILEAC 959
                          970       980       990      1000      1010      1020
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506314133   962 LLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFD 1023
Cdd:pfam00873  960 RLRLRPILMTALAAILGVLPLALSTGAGSELQQPLGIVVFGGLVTSTVLTLLVVPVFYVLFH 1021
PRK10614 PRK10614
multidrug efflux system subunit MdtC; Provisional
16-1034 0e+00

multidrug efflux system subunit MdtC; Provisional


Pssm-ID: 182589 [Multi-domain]  Cd Length: 1025  Bit Score: 1060.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   16 FILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQSSG 95
Cdd:PRK10614    7 FIYRPVATILLSLAITLCGILGFRLLPVAPLPQVDFPVIMVSASLPGASPETMASSVATPLERSLGRIAGVNEMTSSSSL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   96 GASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIYNKVNPADPPILTLAVTSDAMPMTQIQDMVETRVAQKI 175
Cdd:PRK10614   87 GSTRIILQFDFDRDINGAARDVQAAINAAQSLLPSGMPSRPTYRKANPSDAPIMILTLTSDTYSQGQLYDFASTQLAQTI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  176 SQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDDYRKLII 255
Cdd:PRK10614  167 SQIDGVGDVDVGGSSLPAVRVGLNPQALFNQGVSLDDVRQAISNANVRRPQGAVEDGTHRWQIQTNDELKTAAEYQPLII 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  256 AYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKILTDRTTT 335
Cdd:PRK10614  247 HYNNGAAVRLGDVATVTDSVQDVRNAGMTNAKPAILLMIRKLPEANIIQTVDRIRAKLPELRETIPAAIDLQIAQDRSPT 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  336 IRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDDAIVV 415
Cdd:PRK10614  327 IRASLEEVEQTLAISVALVILVVFLFLRSGRATLIPAVAVPVSLIGTFAAMYLCGFSLNNLSLMALTIATGFVVDDAIVV 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  416 IENISRYIEQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISAVVSLTLTPMMC 495
Cdd:PRK10614  407 LENISRHLEAGMKPLQAALQGVREVGFTVLSMSLSLVAVFLPLLLMGGLPGRLFREFAVTLSVAIGISLLVSLTLTPMMC 486
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  496 ARMLKSesqvkHNRFEQASEHFFKRIIA----GYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKGFFPLQDNGLIQ 571
Cdd:PRK10614  487 AWLLKS-----SKPREQKRLRGFGRMLValqqGYGRSLKWVLNHTRWVGVVLLGTIALNVWLYISIPKTFFPEQDTGRLM 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  572 GTLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGvdGSNptLNNGRLQITLKPINQRNDRIAEIIPRLQGKMASI 651
Cdd:PRK10614  562 GFIQADQSISFQAMRGKLQDFMKIIRDDPAVDNVTGFTG--GSR--VNSGMMFITLKPLSERSETAQQVIDRLRVKLAKE 637
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  652 PDVKLYLQPMQDLTIDTQVTRNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDISSDWQARGLIAYIKVDRDIASRLG 731
Cdd:PRK10614  638 PGANLFLMAVQDIRVGGRQSNASYQYTLLSDDLAALREWEPKIRKALAALPELADVNSDQQDKGAEMALTYDRDTMARLG 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  732 ISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPLSTIATVEQRFGPLAINHLA 811
Cdd:PRK10614  718 IDVQAANSLLNNAFGQRQISTIYQPLNQYKVVMEVDPRYTQDISALEKMFVINNEGKAIPLSYFAKWQPANAPLSVNHQG 797
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  812 QFPATTFSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESALGNTLWLIAAAVTAMYIVLGILYESFIHP 891
Cdd:PRK10614  798 LSAASTISFNLPTGKSLSDASAAIERAMTQLGVPSTVRGSFAGTAQVFQETMNSQLILILAAIATVYIVLGILYESYVHP 877
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  892 VTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLPPYEAIYQACLLRFRPILMT 971
Cdd:PRK10614  878 LTILSTLPSAGVGALLALELFNAPFSLIALIGIMLLIGIVKKNAIMMVDFALEAQRNGNLTAQEAIFQACLLRFRPIMMT 957
                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 506314133  972 TMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDKLaRYRRNRKP 1034
Cdd:PRK10614  958 TLAALFGALPLVLSGGDGAELRQPLGITIVGGLVMSQLLTLYTTPVVYLFFDRL-RLRFSRKP 1019
2A0602 TIGR00915
The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins ...
13-1025 6.71e-167

The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Unknown substrate]


Pssm-ID: 273335 [Multi-domain]  Cd Length: 1044  Bit Score: 518.13  E-value: 6.71e-167
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    13 SRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQ 92
Cdd:TIGR00915    2 AKFFIDRPIFAWVIAIIIMLAGTLSILSLPVSQYPSIAPPAITVSASYPGASAQTVQDTVTQVIEQNMNGIDGLRYMSSS 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    93 SSG-GASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIynKVNPA-DPPILTLAVTSDAMPMTQ--IQDMVE 168
Cdd:TIGR00915   82 SDSdGSMTITLTFEQGTDPDIAQVQVQNKLQLATPLLPQEVQRQGV--RVEKAsSNFLMVIGLVSDDGSMTKedLSDYAA 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   169 TRVAQKISQVNGVGLVTLAGGQRpAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSL------DGPTRSVTLSAND 242
Cdd:TIGR00915  160 SNMVDPLSRLEGVGDVQLFGSQY-AMRIWLDPAKLNSYQLTPADVISAISAQNAQISAGQLgglpavPGQQLNATIIAQT 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   243 QMKSVDDYRKLII-AYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLP 321
Cdd:TIGR00915  239 RLQTPEQFENILLkVNTDGSQVRLKDVARVELGGENYSISARFNGKPASGLAIKLATGANALDTAKAVKAELAVLEPFFP 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   322 KSVDIKILTDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMAL 401
Cdd:TIGR00915  319 QGMKYVYPYDTTPFVEASIEEVVHTLIEAIVLVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFAM 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   402 TIATGFVVDDAIVVIENISRYI-EQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAI 480
Cdd:TIGR00915  399 VLAIGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAM 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   481 LISAVVSLTLTPMMCARMLKSESQVKHNrfEQASEHF------FKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLY 554
Cdd:TIGR00915  479 ALSVLVALILTPALCATMLKPIEKGEHH--EKKGGFFgwfnrmFDSSTHGYENGVGKILRRRGRYLLVYVLLVGGMVFLF 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   555 IIIPKGFFPLQDNGLIQGTLEAPQSISFSAMADKQRQVSSLLLQDPA--VENVTTFVGVDGSNPTLNNGRLQITLKPINQ 632
Cdd:TIGR00915  557 VRLPTSFLPDEDQGVFMTIVQLPAGATAERTQAVLAQVTKYLLAKEKanVESVFTVNGFSFAGRGQNMGMAFIRLKDWEE 636
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   633 R---NDRIAEIIPRLQGKMASIPD---VKLYLQPMQDLTidtqvTRNQYQFTLQA---TSLDELSIWVPKLLAELKQRSE 703
Cdd:TIGR00915  637 RtgkENSVFAIAGRATGHFMQIKDamvIAFVPPAILELG-----NATGFDFFLQDragLGHEALLQARNQLLGLAAQNPA 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   704 LVDISSDWQARGLIAYIKVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLN 783
Cdd:TIGR00915  712 LTRVRPNGLEDEPQLKIDIDREKAQALGVSIADINTTLSTAWGSSYVNDFIDRGRVKRVYVQAEEDARMSPEDINKWYVR 791
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   784 GTDGNIVPLSTIATVEQRFGPLAINHLAQFPATTFSFNVSGNASLEQSVNAVRNAAQliEMPKDmtIKFQGTTLAFESAL 863
Cdd:TIGR00915  792 NASGEMVPFSAFATVRWEYGSPQLERYNGLPSMEILGSAAPGVSTGQAMAAMEAIAQ--KLPPG--FGFSWTGMSYEERL 867
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   864 --GNTLWLIAAAVTAMYIVLGILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDF 941
Cdd:TIGR00915  868 sgSQAPALYALSLLVVFLCLAALYESWSIPVSVMLVVPLGIIGALLATTLRGLSNDVYFQVGLLTTIGLSAKNAILIVEF 947
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   942 AlAAEREQGLPPYEAIYQACLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLL 1021
Cdd:TIGR00915  948 A-KELMAQGKSIVEAALEAARLRLRPILMTSLAFILGVVPLAISTGAGSGSQHAIGTGVFGGMVTATVLAIFFVPLFYVV 1026

                   ....
gi 506314133  1022 FDKL 1025
Cdd:TIGR00915 1027 VRRL 1030
CusA COG3696
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
25-1032 2.96e-134

Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];


Pssm-ID: 442911 [Multi-domain]  Cd Length: 1031  Bit Score: 431.76  E-value: 2.96e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   25 LFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQSSGGASVITLQF 104
Cdd:COG3696    18 LLTLLLAAAGIYSLRRLPIDAFPDITNVQVQVITEAPGLSPEEVEQQVTYPIETALNGLPGVKEVRSISRFGLSVVTVIF 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  105 QLTLPLDVAEQEVQAAINAASNLLPNDlpyppiynkVNPADPPILT-------LAVTSDAMPMTQ-----IQDMVetrVA 172
Cdd:COG3696    98 EDGTDIYWARQLVLERLQQVREQLPAG---------VTPELGPISTglgeiyqYTLESDPGKYSLmelrtLQDWV---IR 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  173 QKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDDYRK 252
Cdd:COG3696   166 PQLRSVPGVAEVNSFGGFVKQYQVLVDPAKLRAYGLTLDDVIEALERNNANVGGGYIERGGQEYLVRGIGLIRSLEDIEN 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  253 LIIAYKNGAPVRLQDVATIEQGAENsKLGAWA-NGKQAIVI-NVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKILT 330
Cdd:COG3696   246 IVVKTRNGTPVLLRDVAEVRIGPAP-RRGAATlNGEGEVVGgIVLMLKGENALEVIEAVKAKLAELKPSLPEGVKIVPFY 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  331 DRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVD 410
Cdd:COG3696   325 DRSDLIDRAIHTVTKNLLEGALLVILVLFLFLGNLRAALIVALAIPLSLLFAFIVMRLFGISANLMSLGGLAIDFGIIVD 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  411 DAIVVIENISRYIEQ------GEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISA 484
Cdd:COG3696   405 GAVVMVENILRRLEEnraagtPRERLEVVLEAAREVRRPIFFATLIIILVFLPIFTLEGVEGKLFRPMALTVIFALLGAL 484
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  485 VVSLTLTPMMCARMLKSESQVKHNRfeqasehFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKGFFPL 564
Cdd:COG3696   485 LLSLTLVPVLASLLLRGKVPEKENP-------LVRWLKRLYRPLLRWALRHPKLVLAVALVLLVLALALFPRLGSEFLPE 557
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  565 QDNG--LIQGTLeaPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGV--DGSNPT-LNNGRLQITLKPINQRNDRI-- 637
Cdd:COG3696   558 LDEGdlLVMATL--PPGISLEESVELGQQVERILKSFPEVESVVSRTGRaeDATDPMgVNMSETFVILKPRSEWRSGRtk 635
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  638 AEIIPRLQGKMASIPDVKL-YLQPMQD-----LT-IDTQVtrnqyqftlqA-----TSLDELSIWVPKLLAELKQRSELV 705
Cdd:COG3696   636 EELIAEMREALEQIPGVNFnFSQPIQMrvdelLSgVRADV----------AvkifgDDLDVLRRLAEQIEAVLKTVPGAA 705
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  706 DISSDWQARGLIAYIKVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQY--RVVLEHDMKSTPglAAFDNIRLN 783
Cdd:COG3696   706 DVQVERVTGLPQLDIRIDRDAAARYGLNVADVQDVVETAIGGKAVGQVYEGERRFdiVVRLPEELRDDP--EAIRNLPIP 783
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  784 GTDGNIVPLSTIATVEQRFGPLAINHLAQFPATTFSFNVSGnASLEQSVNAVRNA-AQLIEMPKDMTIKFQGTTLAFESA 862
Cdd:COG3696   784 TPSGAQVPLSQVADIEVVEGPNQISRENGRRRIVVQANVRG-RDLGSFVAEAQAKvAEQVKLPPGYYIEWGGQFENLQRA 862
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  863 LGNTLWLIAAAVTAMYIVLGILYESFIHPVTILSTLPTAGVGALLALMMTGQEL--------------DVIaiigiilli 928
Cdd:COG3696   863 TARLAIVVPLALLLIFLLLYLAFGSVRDALLILLNVPFALIGGVLALWLRGMPLsvsagvgfialfgvAVL--------- 933
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  929 givkkNAIMMIDFALAAeREQGLPPYEAIYQACLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQ 1008
Cdd:COG3696   934 -----NGVVLVSYINQL-RAEGLDLREAIIEGALERLRPVLMTALVAALGLLPMALSTGPGSEVQRPLATVVIGGLITST 1007
                        1050      1060
                  ....*....|....*....|....
gi 506314133 1009 ILTLFTTPVVYLLFDKLARYRRNR 1032
Cdd:COG3696  1008 LLTLLVLPALYLLFGRRRLRRAAA 1031
PRK09579 PRK09579
multidrug efflux RND transporter permease subunit;
16-1024 1.13e-132

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169983 [Multi-domain]  Cd Length: 1017  Bit Score: 427.33  E-value: 1.13e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   16 FILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQSSG 95
Cdd:PRK09579    7 FIRRPVLASVVSLLIVLLGFQAWSKLQIRQYPQMENALITVTTAYPGANAETIQGYITQPLQQSLASAEGIDYMTSVSRQ 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   96 GASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPyPPIYNKVNPADPPILTLAVTSDAMPMTQIQDMVETRVAQKI 175
Cdd:PRK09579   87 NFSIISIYARIGADSDRLFTELLAKANEVKNQLPQDAE-DPVLSKEAADASALMYISFYSEEMSNPQITDYLSRVIQPKL 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  176 SQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDDYRKLII 255
Cdd:PRK09579  166 ATLPGMAEAEILGNQVFAMRLWLDPVKLAGFGLSAGDVTQAVRRYNFLSAAGEVKGEYVVTSINASTELKSAEAFAAIPV 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  256 AYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKILTDRTTT 335
Cdd:PRK09579  246 KTSGDSRVLLGDVARVEMGAENYDSISSFDGIPSVYIGIKATPSANPLDVIKEVRAIMPELESQLPPNLKVSIAYDATLF 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  336 IRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDDAIVV 415
Cdd:PRK09579  326 IQASIDEVVKTLGEAVLIVIVVVFLFLGALRSVLIPVVTIPLSMIGVLFFMQMMGYSINLLTLLAMVLAIGLVVDDAIVV 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  416 IENISRYIEQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISAVVSLTLTPMMC 495
Cdd:PRK09579  406 VENIHRHIEEGKSPFDAALEGAREIAMPVVSMTITLAAVYAPIGFLTGLTGALFKEFALTLAGAVIISGIVALTLSPMMC 485
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  496 ARMLKSESQVKHnrFEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKGFFPLQDNGLIQGTLE 575
Cdd:PRK09579  486 ALLLRHEENPSG--LAHRLDRLFERLKQRYQRALHGTLNTRPVVLVFAVIVLALIPVLLKFTQSELAPEEDQGIIFMMSS 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  576 APQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGVDGsnptLNNGRLQITLKPINQRNDRIAEIIPRLQGKMASIPDVK 655
Cdd:PRK09579  564 SPQPANLDYLNAYTDEFTPIFKSFPEYYSSFQINGFNG----VQSGIGGFLLKPWNERERTQMELLPLVQAKLEEIPGLQ 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  656 LYLQPMQDLTIDTQVTrnQYQFTLQATSLDELSIWVPKLLAELKQRS---ELVDISSDWQARGLIayIKVDRDIASRLGI 732
Cdd:PRK09579  640 IFGFNLPSLPGTGEGL--PFQFVINTANDYESLLQVAQRVKQRAQESgkfAFLDIDLAFDKPEVV--VDIDRAKAAQMGV 715
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  733 SMAAIDNALYNAFGQRLISTIYTQANQYRVV--LEHDMKSTPGLaaFDNIRLNGTDGNIVPLSTIATVEQRFGPLAINHL 810
Cdd:PRK09579  716 SMQDLGGTLATLLGEGEINRFTIDGRSYKVIaqVERPYRDNPGW--LNNYYVKNEQGQLLPLSTLITLSDRARPRQLNQF 793
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  811 AQFPATTFS-FNVsgnASLEQSVNAVRNAAQLiEMPKDMTIKFQGTTLAFESAlGNTLWL-IAAAVTAMYIVLGILYESF 888
Cdd:PRK09579  794 QQLNSAIISgFPI---VSMGEAIETVQQIARE-EAPEGFAFDYAGASRQYVQE-GSALWVtFGLALAIIFLVLAAQFESF 868
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  889 IHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQGLPPYEAIYQACLLRFRPI 968
Cdd:PRK09579  869 RDPLVILVTVPLSICGALIPLFLGVSSMNIYTQVGLVTLIGLISKHGILIVEFANQLRHEQGLSRREAIEEAAAIRLRPV 948
                         970       980       990      1000      1010
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 506314133  969 LMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDK 1024
Cdd:PRK09579  949 LMTTAAMVFGMVPLILATGAGAVSRFDIGLVIATGMSIGTLFTLFVLPCIYTLLAK 1004
PRK09577 PRK09577
multidrug efflux RND transporter permease subunit;
13-1032 8.39e-126

multidrug efflux RND transporter permease subunit;


Pssm-ID: 169981 [Multi-domain]  Cd Length: 1032  Bit Score: 409.24  E-value: 8.39e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   13 SRQFILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQ 92
Cdd:PRK09577    2 ARFFIDRPVFAWVISLFIMLGGIFAIRALPVAQYPDIAPPVVSIYATYPGASAQVVEESVTALIEREMNGAPGLLYTSAT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   93 SSGGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIYNKvNPADPPILTLAVTSDAMPMTQIQ--DMVETR 170
Cdd:PRK09577   82 SSAGQASLSLTFKQGVNADLAAVEVQNRLKTVEARLPEPVRRDGIQVE-KAADNIQLIVSLTSDDGRLTGVElgEYASAN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  171 VAQKISQVNGVGLVTLAGGQRpAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSL------DGPTRSVTLSANDQM 244
Cdd:PRK09577  161 VLQALRRVEGVGKVQFWGAEY-AMRIWPDPVKLAALGLTASDIASAVRAHNARVTIGDIgrsavpDSAPIAATVFADAPL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  245 KSVDDYRKLIIAYK-NGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKS 323
Cdd:PRK09577  240 KTPEDFGAIALRARaDGSALYLRDVARIEFGGNDYNYPSYVNGKTATGMGIKLAPGSNAVATEKRVRATMDELSRYFPPG 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  324 VDIKILTDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTI 403
Cdd:PRK09577  320 VKYQIPYETSSFVRVSMNKVVTTLIEAGVLVFLVMFLFMQNFRATLIPTLVVPVALLGTFGVMLAAGFSINVLTMFGMVL 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  404 ATGFVVDDAIVVIENISRYI-EQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILI 482
Cdd:PRK09577  400 AIGILVDDAIVVVENVERLMvEEGLSPYDATVKAMKQISGAIVGITVVLTSVFVPMAFFGGAVGNIYRQFALSLAVSIGF 479
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  483 SAVVSLTLTPMMCARMLKSESQVKHNR--FEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKG 560
Cdd:PRK09577  480 SAFLALSLTPALCATLLKPVDGDHHEKrgFFGWFNRFVARSTQRYATRVGAILKRPLRWLVVYGALTAAAALLFTRLPTA 559
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  561 FFPLQDNGLIQGTLEAPQSISFSAMADKQRQVSSLLLQDPAVENVTTFVGVDGSNPTLNNGRLQITLKPINQR---NDRI 637
Cdd:PRK09577  560 FLPDEDQGNFMVMVIRPQGTPLAETMQSVREVESYLRRHEPVAYTFALGGFNLYGEGPNGGMIFVTLKDWKERkaaRDHV 639
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  638 AEIIPRLQGKMASIPDVKLY---LQPMQDLTidtqvTRNQYQFTLQ---ATSLDELSIWVPKLLAELKQRSELVDISSDW 711
Cdd:PRK09577  640 QAIVARINERFAGTPNTTVFamnSPALPDLG-----STSGFDFRLQdrgGLGYAAFVAAREQLLAEGAKDPALTDLMFAG 714
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  712 QARGLIAYIKVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVP 791
Cdd:PRK09577  715 TQDAPQLKLDIDRAKASALGVSMDEINTTLAVMFGSDYIGDFMHGSQVRRVIVQADGRHRLDPDDVKKLRVRNAQGEMVP 794
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  792 LSTIATVEQRFGPLAINHLAQFPattfSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESALGNTL--WL 869
Cdd:PRK09577  795 LAAFATLHWTLGPPQLTRYNGYP----SFTINGSAAPGHSSGEAMAAIERIAATLPAGIGYAWSGQSFEERLSGAQapML 870
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  870 IAAAVTAMYIVLGILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFA--LAAer 947
Cdd:PRK09577  871 FALSVLVVFLALAALYESWSIPFAVMLVVPLGVIGAVLGVTLRGMPNDIYFKVGLIATIGLSAKNAILIVEVAkdLVA-- 948
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  948 eQGLPPYEAIYQACLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFDKLAR 1027
Cdd:PRK09577  949 -QRMSLADAALEAARLRLRPIVMTSLAFGVGVLPLAFASGAASGAQIAIGTGVLGGVITATVLAVFLVPLFFVVVGRLFD 1027

                  ....*
gi 506314133 1028 YRRNR 1032
Cdd:PRK09577 1028 VGPRR 1032
PRK15127 PRK15127
multidrug efflux RND transporter permease subunit AcrB;
16-1040 3.44e-114

multidrug efflux RND transporter permease subunit AcrB;


Pssm-ID: 185081 [Multi-domain]  Cd Length: 1049  Bit Score: 378.09  E-value: 3.44e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   16 FILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQS-S 94
Cdd:PRK15127    5 FIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSdS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   95 GGASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIynKVNPADPPILTLA-VTSDAMPMTQ--IQDMVETRV 171
Cdd:PRK15127   85 TGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQEVQQQGV--SVEKSSSSFLMVVgVINTDGTMTQedISDYVAANM 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  172 AQKISQVNGVGLVTLAGGQRpAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDG--PTRSVTLSAN----DQMK 245
Cdd:PRK15127  163 KDPISRTSGVGDVQLFGSQY-AMRIWMNPNELNKFQLTPVDVINAIKAQNAQVAAGQLGGtpPVKGQQLNASiiaqTRLT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  246 SVDDYRKLIIAY-KNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSV 324
Cdd:PRK15127  242 STEEFGKILLKVnQDGSRVRLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANALDTAAAIRAELAKMEPFFPSGL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  325 DIKILTDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIA 404
Cdd:PRK15127  322 KIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLA 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  405 TGFVVDDAIVVIENISRYI-EQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILIS 483
Cdd:PRK15127  402 IGLLVDDAIVVVENVERVMaEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMALS 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  484 AVVSLTLTPMMCARMLKSESQVKHNRFEQASEHFFKRIIAGYTVWLKKALNHPLITLG----IALSTLALTALLYIIIPK 559
Cdd:PRK15127  482 VLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGNILRSTGrylvLYLIIVVGMAYLFVRLPS 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  560 GFFPLQDNGLIQGTLEAPQSISFSAMADKQRQVSSLLL--QDPAVENVTTFVGVDGSNPTLNNGRLQITLKPINQR---N 634
Cdd:PRK15127  562 SFLPDEDQGVFLTMVQLPAGATQERTQKVLNEVTDYYLtkEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRpgeE 641
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  635 DRIAEIIPRLQGKMASIPDVKLYLQPMQDLTIDTQVTRNQYQFTLQAT-SLDELSIWVPKLLAELKQRSE-LVDISSDWQ 712
Cdd:PRK15127  642 NKVEAITMRATRAFSQIKDAMVFAFNLPAIVELGTATGFDFELIDQAGlGHEKLTQARNQLLGEAAKHPDmLVGVRPNGL 721
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  713 ARGLIAYIKVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVPL 792
Cdd:PRK15127  722 EDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPF 801
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  793 STIATVEQRFGPLAINHLAQFPattfSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESAL-GNTL-WLI 870
Cdd:PRK15127  802 SAFSSSRWEYGSPRLERYNGLP----SMEILGQAAPGKSTGEAMELMEELASKLPTGVGYDWTGMSYQERLsGNQApALY 877
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  871 AAAVTAMYIVLGILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFALAAEREQG 950
Cdd:PRK15127  878 AISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEG 957
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  951 LPPYEAIYQACLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLlfdkLARYRR 1030
Cdd:PRK15127  958 KGLIEATLEAVRMRLRPILMTSLAFILGVMPLVISSGAGSGAQNAVGTGVMGGMVTATVLAIFFVPVFFV----VVRRRF 1033
                        1050
                  ....*....|
gi 506314133 1031 NRKPGELDNS 1040
Cdd:PRK15127 1034 SRKNEDIEHS 1043
PRK10555 PRK10555
multidrug efflux RND transporter permease AcrD;
16-1021 1.11e-109

multidrug efflux RND transporter permease AcrD;


Pssm-ID: 182544 [Multi-domain]  Cd Length: 1037  Bit Score: 365.69  E-value: 1.11e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   16 FILRPVATTLFMVAILLAGIIGYRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQSSG 95
Cdd:PRK10555    5 FIDRPIFAWVLAILLCLTGTLAIFSLPVEQYPDLAPPNVRITANYPGASAQTLENTVTQVIEQNMTGLDNLMYMSSQSSG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   96 -GASVITLQFQLTLPLDVAEQEVQAAINAASNLLPNDLPYPPIyNKVNPADPPILTLA-VTSD-AMPMTQIQDMVETRVA 172
Cdd:PRK10555   85 tGQASVTLSFKAGTDPDEAVQQVQNQLQSAMRKLPQAVQNQGV-TVRKTGDTNILTIAfVSTDgSMDKQDIADYVASNIQ 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  173 QKISQVNGVGLVTLAGGQRpAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGpTRSV-------TLSANDQMK 245
Cdd:PRK10555  164 DPLSRVNGVGDIDAYGSQY-SMRIWLDPAKLNSFQMTTKDVTDAIESQNAQIAVGQLGG-TPSVdkqalnaTINAQSLLQ 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  246 SVDDYRKLII-AYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSV 324
Cdd:PRK10555  242 TPEQFRDITLrVNQDGSEVTLGDVATVELGAEKYDYLSRFNGKPASGLGVKLASGANEMATAKLVLNRLDELAQYFPHGL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  325 DIKILTDRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIA 404
Cdd:PRK10555  322 EYKVAYETTSFVKASIEDVVKTLLEAIALVFLVMYLFLQNFRATLIPTIAVPVVLMGTFSVLYAFGYSINTLTMFAMVLA 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  405 TGFVVDDAIVVIENISRYI-EQGEKPMAAALKGAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILIS 483
Cdd:PRK10555  402 IGLLVDDAIVVVENVERIMsEEGLTPREATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGTTGAIYRQFSITIVSAMVLS 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  484 AVVSLTLTPMMCARMLKSESQVKHNR---FEQASEHFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKG 560
Cdd:PRK10555  482 VLVAMILTPALCATLLKPLKKGEHHGqkgFFGWFNRMFNRNAERYEKGVAKILHRSLRWILIYVLLLGGMVFLFLRLPTS 561
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  561 FFPLQDNGLIQGTLEAPQSISFSAMADKQRQVSSLLLQDPAvENVTTFVGVDGSNPTLNN---GRLQITLKPINQR---N 634
Cdd:PRK10555  562 FLPLEDRGMFTTSVQLPSGSTQQQTLKVVEKVEKYYFTHEK-DNVMSVFATVGSGPGGNGqnvARMFIRLKDWDERdskT 640
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  635 DRIAEIIPRLQGKMASIPDVKLYLQpmQDLTIDTQVTRNQYQFTLQ---ATSLDELSIWVPKLLAELKQRSELVDISSDW 711
Cdd:PRK10555  641 GTSFAIIERATKAFNKIKEARVIAS--SPPAISGLGSSAGFDMELQdhaGAGHDALMAARNQLLALAAKNPELTRVRHNG 718
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  712 QARGLIAYIKVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRLNGTDGNIVP 791
Cdd:PRK10555  719 LDDSPQLQIDIDQRKAQALGVSIDDINDTLQTAWGSSYVNDFMDRGRVKKVYVQAAAPYRMLPDDINLWYVRNKDGGMVP 798
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  792 LSTIATVEQRFGPLAINHLAQFPATTFSFNVSGNASLEQSVNAVRNAAQliEMPKDMTIKFQGTTLAFESALGNTLWLIA 871
Cdd:PRK10555  799 FSAFATSRWETGSPRLERYNGYSAVEIVGEAAPGVSTGTAMDIMESLVK--QLPNGFGLEWTAMSYQERLSGAQAPALYA 876
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  872 AAVTAMYIVLGILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFAlAAEREQGL 951
Cdd:PRK10555  877 ISLLVVFLCLAALYESWSVPFSVMLVVPLGVIGALLATWMRGLENDVYFQVGLLTVIGLSAKNAILIVEFA-NEMNQKGH 955
                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  952 PPYEAIYQACLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLL 1021
Cdd:PRK10555  956 DLFEATLHASRQRLRPILMTSLAFIFGVLPMATSTGAGSGSQHAVGTGVMGGMISATILAIFFVPLFFVL 1025
2A0601 TIGR00914
heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation ...
25-1038 2.14e-82

heavy metal efflux pump, CzcA family; This model represents a family of H+/heavy metal cation antiporters. This family is one of several subfamilies within the scope of pfam00873. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 129992 [Multi-domain]  Cd Length: 1051  Bit Score: 289.74  E-value: 2.14e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133    25 LFMVAILLAGIIG---YRMLPVSALPAVDYPTIQVVTFYPGASPDVMTSAVTAPLERQLGQMSGLKQMASQSSGGASVIT 101
Cdd:TIGR00914   15 LVLLATLVMAILGiwsYNRLPIDAVPDITNVQVQINTSAPGYSPLEVEQRVTYPIETAMAGLPGLETTRSLSRYGLSQVT 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   102 LQFQLTLPLDVAEQEVQAAINAASNLLPNDLP--YPPI---------YNKVNPADPPILTLAVtSDAMPMTQIQDMVetr 170
Cdd:TIGR00914   95 VIFKDGTDLYFARQLVNERLQQARDNLPEGVSpeMGPIstglgeiflYTVEAEEGARKKDGGA-YTLTDLRTIQDWI--- 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   171 VAQKISQVNGVGLVTLAGGQRPAVRVKLNAQAVAAQGLDSETIRTAINSANVNSAKGSLDGPTRSVTLSANDQMKSVDDY 250
Cdd:TIGR00914  171 IRPQLRTVPGVAEVNSIGGYVKQFLVAPDPEKLAAYGLSLADVVNALERNNQNVGAGYIERRGEQYLVRAPGQVQSMDDI 250
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   251 RKLIIAYKNGAPVRLQDVATIEQGAENSKLGAWANGKQAIVINVQRQPGVNVIETTDNIRQMLPELISSLPKSVDIKILT 330
Cdd:TIGR00914  251 RNIVIATGEGVPIRIRDVARVQIGKELRTGAATENGKEVVLGTVFMLIGENSRTVAQAVGDKLETINKTLPEGVEIVTTY 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   331 DRTTTIRASVKDVQFELLLAVVLVVMVIYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALtiATGFVVD 410
Cdd:TIGR00914  331 DRSQLVDAAIATVKKNLLEGALLVIVILFLFLGNIRAALIAATVIPLSLLITFIGMVFQGISANLMSLGAL--DFGLIVD 408
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   411 DAIVVIENISRYIEQGEKPMAAALK----------GAGEIGFTIISLTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAI 480
Cdd:TIGR00914  409 GAVVIVENAHRRLAEAQHHHGRQLTlkerlhevfaASREVRRPLIFGQLIITLVFLPIFTLTGVEGKMFHPMAFTVVLAL 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   481 LISAVVSLTLTPMMCARMLKSESQVKHNRfeqasehFFKRIIAGYTVWLKKALNHPLITLGIALSTLALTALLYIIIPKG 560
Cdd:TIGR00914  489 AGAMILSLTFVPAAVALFIRGKVAEKENR-------LMRVLKRRYEPLLERVLAWPAVVLGAAAVSIVLVVWIASRVGGE 561
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   561 FFPLQDNG-LIQGTLEAPqSISFSAMADKQRQVSSLLLQDPAVENV-----TTFVGVDGSNPTLNNGrlQITLKPINQRN 634
Cdd:TIGR00914  562 FIPSLNEGdLAYQALRIP-GTSLAQSVAMQQTLEKLIKSFPEVARVfaktgTAEIATDPMPPNASDT--YIILKPESQWP 638
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   635 DRI---AEIIPRLQGKMASIP-DVKLYLQPMQdLTIDTQVT--RNQYQFTLQATSLDELSIWVPKLLAELKQRSELVDIS 708
Cdd:TIGR00914  639 EGKktkEDLIEEIQEATVRIPgNNYEFTQPIQ-MRFNELISgvRSDVAVKVFGDDLDDLDATAEKISAVLKGVPGAADVK 717
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   709 SDWQARGLIAYIKVDRDIASRLGISMAAIDNALYNAFGQRLISTIYTQANQYRVVLEHDMKSTPGLAAFDNIRL-----N 783
Cdd:TIGR00914  718 VEQTTGLPYLTVEIDREKAARYGLTVGDVQDTVATAVGGRMSGETFEGDRRFDIVIRLPESLRESPQALRQLPIplplsE 797
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   784 GTDGNIVPLSTIATVEQRFGPLAINHLAQFPATTFSFNVSGNASLEQSVNAVRNAAQLIEMPKDMTIKFQGTTLAFESAL 863
Cdd:TIGR00914  798 DARKQFIPLSDVADLRVSPGPNQISRENGKRRVVVSANVRGRDLGSFVDDAKKAIAEQVKLPPGYWITWGGQFEQLQSAT 877
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   864 GNTLWLIAAAVTAMYIVLGILYESFIHPVTILSTLPTAGVGALLALMMTGQELDVIAIIGIILLIGIVKKNAIMMIDFaL 943
Cdd:TIGR00914  878 KRLQIVVPVTLLLIFVLLYAAFGNVKDALLVFTGIPFALTGGVFALWLRGIPLSISAAVGFIALSGVAVLNGLVMISF-I 956
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   944 AAEREQGLPPYEAIYQACLLRFRPILMTTMAALFGALPLMLSAGVGAELRRPLGICMVGGLIMSQILTLFTTPVVYLLFd 1023
Cdd:TIGR00914  957 RKLLEEGPSLDEAVYEGALTRVRPVLMTALVASLGFVPMAIATGTGAEVQRPLATVVIGGIITATLLTLFVLPALYRLV- 1035
                         1050
                   ....*....|....*
gi 506314133  1024 kLARYRRNRKPGELD 1038
Cdd:TIGR00914 1036 -HRRRHKGRKEHEPL 1049
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
358-542 1.48e-13

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 75.28  E-value: 1.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  358 IYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDDAIVVIENISRYIEQGEKPMAAALKGA 437
Cdd:COG1033   235 LFLFFRSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKGLDKREALREAL 314
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  438 GEIGFTIISLTFSLIAVLIPLFFMgDIvgRLFREFAITLAIAILISAVVSLTLTPMMCARMLKSESQVKHNRFEQASEHF 517
Cdd:COG1033   315 RKLGPPVLLTSLTTAIGFLSLLFS-DI--PPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPELGRL 391
                         170       180
                  ....*....|....*....|....*
gi 506314133  518 FKRIIagytvwlKKALNHPLITLGI 542
Cdd:COG1033   392 LAKLA-------RFVLRRPKVILVV 409
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
358-492 1.77e-11

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 68.35  E-value: 1.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  358 IYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDDAIVVIENISRYIEQGEKPMAAALKGA 437
Cdd:COG1033   622 LLLAFRSLRLGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERRKGGDLEEAIRRAL 701
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 506314133  438 GEIGFTIISLTFSLIAVLIPLFFmGDIVGrlFREFAITLAIAILISAVVSLTLTP 492
Cdd:COG1033   702 RTTGKAILFTSLTLAAGFGVLLF-SSFPP--LADFGLLLALGLLVALLAALLLLP 753
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
362-496 7.31e-07

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 52.29  E-value: 7.31e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   362 LRSGIATLIPSIAVPLSLVGTFAIMYFC----GFSINNLT---LMALTIATGfvVDDAIVVIENISRYIEQGEKPMAAAL 434
Cdd:pfam03176  163 YRSVVAALLPLLTVGLSLGAAQGLVAILahilGIGLSTFAlnlLVVLLIAVG--TDYALFLVSRYREELRAGEDREEAVI 240
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506314133   435 KGAGEIGFTIislTFSLIAVLIPLFFMGDIVGRLFREFAITLAIAILISAVVSLTLTPMMCA 496
Cdd:pfam03176  241 RAVRGTGKVV---TAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLA 299
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
360-492 5.96e-06

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 50.53  E-value: 5.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  360 LFLRSGIATLIPSIAVPLSLVGTFAIMYFCG--FSINNLT---LMALTIATGfvVDDAIVVIeniSRYIEQ---GEKP-- 429
Cdd:COG2409   188 LVFRSLVAALLPLLTAGLAVGVALGLLALLAafTDVSSFApnlLTMLGLGVG--IDYALFLV---SRYREElraGEDRee 262
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506314133  430 -MAAALKGAGEI----GFTIIsltfslIAvLIPLFFMGDivgRLFREFAITLAIAILISAVVSLTLTP 492
Cdd:COG2409   263 aVARAVATAGRAvlfsGLTVA------IA-LLGLLLAGL---PFLRSMGPAAAIGVAVAVLAALTLLP 320
secD PRK05812
preprotein translocase subunit SecD; Reviewed
358-494 1.50e-05

preprotein translocase subunit SecD; Reviewed


Pssm-ID: 235615 [Multi-domain]  Cd Length: 462  Bit Score: 48.68  E-value: 1.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  358 IYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSinnLTL-----MALTIatGFVVDdAIVVI-ENISRYIEQGEKPMA 431
Cdd:PRK05812  312 LFMILYYRLFGLIANIALVANLVLILAVLSLLGAT---LTLpgiagIVLTI--GMAVD-ANVLIfERIREELREGRSLRS 385
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  432 AAlkgagEIGF-----TIIS--LTfSLIAVLIpLFFMGdiVGrLFREFAITLAIAILISAVVSLTLTPMM 494
Cdd:PRK05812  386 AI-----EAGFkrafsTILDsnIT-TLIAAII-LYALG--TG-PVKGFAVTLGIGILTSMFTAITVTRAL 445
secD TIGR01129
protein-export membrane protein SecD; Members of this family are highly variable in length ...
358-491 3.01e-05

protein-export membrane protein SecD; Members of this family are highly variable in length immediately after the well-conserved motif LGLGLXGG at the amino-terminal end of this model. Archaeal homologs are not included in the seed and score between the trusted and noise cutoffs. SecD from Mycobacterium tuberculosis has a long Pro-rich insert. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273456 [Multi-domain]  Cd Length: 397  Bit Score: 47.67  E-value: 3.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   358 IYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSinnLTL-----MALTIatGFVVDDAIVVIENISRYIEQGEKPMAA 432
Cdd:TIGR01129  263 VFMILYYRLFGLIAAIALVINIVLILAILSAFGAT---LTLpgiagLILTI--GMAVDANVLIYERIKEELRLGKSVRQA 337
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506314133   433 AlkgagEIGF-----TIIS--LTfSLIAVLIpLFFMGdiVGrLFREFAITLAIAILISAVVSLTLT 491
Cdd:TIGR01129  338 I-----EAGFerafsTIFDanIT-TLIAALI-LYVFG--TG-PVKGFAVTLAIGIIASLFTALVFT 393
SecD COG0342
Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular ...
358-494 3.69e-05

Preprotein translocase subunit SecD [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440111 [Multi-domain]  Cd Length: 434  Bit Score: 47.42  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  358 IYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFsinNLTL-----MALTIATGfvVDDAIVVIEnisRYIEQGE--KPM 430
Cdd:COG0342   286 LFMLLYYRLPGLVANIALALNVVLLLGVLSLLGA---TLTLpgiagIILTIGMA--VDANVLIFE---RIREELRagRSL 357
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 506314133  431 AAALkgagEIGF-----TIIS--LTfSLIAVLIpLFFMGdiVGRLfREFAITLAIAILISAVVSLTLTPMM 494
Cdd:COG0342   358 RAAI----EAGFkrafsTILDanVT-TLIAAVV-LFVLG--TGPV-KGFAVTLILGILISMFTAVPVTRPL 419
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
822-1039 4.94e-05

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 47.55  E-value: 4.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  822 VSGNASLEQSVNAVRNAAQLIEmPKDMTIKFQGT---TLAFESALGNTL-WLIAAAVTAMYIVLGILYESFIHPVTILST 897
Cdd:COG1033   173 LSSDLDRKEVVAEIRAIIAKYE-DPGVEVYLTGFpvlRGDIAEAIQSDLaIFFPLALLLILLLLFLFFRSLRGVLLPLLV 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  898 LpTAGVGALLALM-MTGQELDVIAiigiilligivkkNAIMMIDFALA------------AEREQGLPPYEAIYQACLLR 964
Cdd:COG1033   252 V-LLAVIWTLGLMgLLGIPLSPLT-------------ILVPPLLLAIGidygihllnryrEERRKGLDKREALREALRKL 317
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 506314133  965 FRPILMTTMAALFGALPLMLSA-GVGAELrrplGICMVGGLIMSQILTLFTTPVVYLLFDKL-ARYRRNRKPGELDN 1039
Cdd:COG1033   318 GPPVLLTSLTTAIGFLSLLFSDiPPIRDF----GIVAAIGVLLAFLTSLTLLPALLSLLPRPkPKTRRLKKPPELGR 390
PRK13024 PRK13024
bifunctional preprotein translocase subunit SecD/SecF; Reviewed
358-501 5.45e-05

bifunctional preprotein translocase subunit SecD/SecF; Reviewed


Pssm-ID: 237276 [Multi-domain]  Cd Length: 755  Bit Score: 47.15  E-value: 5.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  358 IYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDDAIVVIENISRYIEQGEKPMAAALKGA 437
Cdd:PRK13024  281 LFMLVYYGLPGLIANIALLLYIFLTLGALSSLGAVLTLPGIAGLVLGIGMAVDANVLIFERIKEELRKGKSLKKAFKKGF 360
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506314133  438 GEIGFTII--SLTfSLIAVLIpLFFMGDIvgrLFREFAITLAIAILISAVVSLTLTPMMCARMLKS 501
Cdd:PRK13024  361 KNAFSTILdsNIT-TLIAAAI-LFFFGTG---PVKGFATTLIIGILASLFTAVFLTRLLLELLVKR 421
2A0604s01 TIGR00916
protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY ...
358-488 2.77e-04

protein-export membrane protein, SecD/SecF family; The SecA,SecB,SecD,SecE,SecF,SecG and SecY proteins form the protein translocation appartus in prokaryotes. This family is specific for the SecD and SecF proteins. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 273336 [Multi-domain]  Cd Length: 192  Bit Score: 43.01  E-value: 2.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133   358 IYLFLRSGIATLIPSIAVPLS-LVGTFAIMYFCGFSINNLTLMALTIATGFVVDDAIVVIENISryiEQGEKPMAAALKG 436
Cdd:TIGR00916   62 LYMLLRYEWRGAIAAIAALVHdVILILGVLSLFGATLTLPGIAGLLTIIGYSVDDTVVIFDRIR---EELRKYKGRTFRE 138
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 506314133   437 AGEIGF------TIISLTFSLIAVLIPLFFMGDIVgrlfREFAITLAIAILISAVVSL 488
Cdd:TIGR00916  139 AINLGInqtlsrIIDTNVTTLLAVLALYVFGGGAI----KGFALTLGIGVIAGTYSSI 192
PRK13023 PRK13023
protein translocase subunit SecDF;
358-501 2.19e-03

protein translocase subunit SecDF;


Pssm-ID: 171842 [Multi-domain]  Cd Length: 758  Bit Score: 41.91  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  358 IYLFLRSGIATLIPSIAVPLSLVGTFAIMYFCGFSINNLTLMALTIATGFVVDDAIVVIENISRYIEQGEKPMAAALKGA 437
Cdd:PRK13023  293 LFMVLSYGILGVIALVALVVNIIILTAVLSLIGASISLASIAGLVLTIGLAVDAHILIYERVREDRRKGYSVVQAMESGF 372
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 506314133  438 GEIGFTIISLTFSLIAVLIPLFFMGDivgRLFREFAITLAIAILISAVVSLTLTPMMCARMLKS 501
Cdd:PRK13023  373 YRALSTIVDANLTTLIAALVLFLLGS---GTVHGFALTVAIGIGTTLFTTLTFTRLLIAQWVRT 433
PRK14726 PRK14726
protein translocase subunit SecDF;
365-496 5.32e-03

protein translocase subunit SecDF;


Pssm-ID: 237805 [Multi-domain]  Cd Length: 855  Bit Score: 40.86  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506314133  365 GIATLIPSIAVPLSLVGTFAIMYFCGFSinnLTL-----MALTIatGFVVDDAIVVIENIsRYIEQGEKPMAAALkgagE 439
Cdd:PRK14726  394 GFLGVIAVIALIVNVVLIIAVLSLLGAT---LTLpgiagIVLTI--GMAVDSNVLIYERI-REEEKTGHSLIQAL----D 463
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 506314133  440 IGF-----TIISLTFSLIAVLIPLFFMGDivgRLFREFAITLAIAILISAVVSLTLTPMMCA 496
Cdd:PRK14726  464 RGFsralaTIVDANVTILIAAVILFFLGS---GAVRGFAVTLAVGILTTVFTAFTLTRSLVA 522
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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