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Conserved domains on  [gi|506352238|ref|WP_015871957|]
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carboxymuconolactone decarboxylase family protein [Edwardsiella ictaluri]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 11450212)

carboxymuconolactone decarboxylase family protein similar to Escherichia coli protein YnjA and Bacillus subtilis protein YdfG

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4002925

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 45-180 7.66e-38

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


:

Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 127.30  E-value: 7.66e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506352238  45 PRLFWLMALFVGYLeRRRATLSPGLRALVMTRVSQRCDCAFCIDANGLRLAQRCGSLDKVLAVATWQEADCFDAMERAAL 124
Cdd:COG2128    3 PELLKAFLALSGAL-MAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 506352238 125 AYADAVSATPPQVSAALKAELRRHFDDCALTELTALVAFQNLSARFNAALDIPAQG 180
Cdd:COG2128   82 AFAEALTRTPGGVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGTPPDP 137
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 45-180 7.66e-38

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 127.30  E-value: 7.66e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506352238  45 PRLFWLMALFVGYLeRRRATLSPGLRALVMTRVSQRCDCAFCIDANGLRLAQRCGSLDKVLAVATWQEADCFDAMERAAL 124
Cdd:COG2128    3 PELLKAFLALSGAL-MAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 506352238 125 AYADAVSATPPQVSAALKAELRRHFDDCALTELTALVAFQNLSARFNAALDIPAQG 180
Cdd:COG2128   82 AFAEALTRTPGGVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGTPPDP 137
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 65-177 4.97e-09

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 53.18  E-value: 4.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506352238   65 LSPGLRALVMTRVSQRCDCAFCIDANGLRLAQRCGSLDKVLAVATWQEADCFDAMERAALAYADAVSATPPQVSAALKAE 144
Cdd:TIGR01926  60 LSRAERELIAVVVSRANGCVYCAAVHGAALRQLSGDPDLADAVAVNFRDADLSPRERAMLDFAVKLTATPAKVNEADFAA 139

                          90       100       110
                  ....*....|....*....|....*....|....
gi 506352238  145 LRRH-FDDCALTELTALVAFQNLSARFNAALDIP 177
Cdd:TIGR01926 140 LRAAgFSDLDILDLIHSVAFFNWANRLMLALGEP 173
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 45-129 1.21e-05

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 41.91  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506352238   45 PRLFWLMALFVGYLeRRRATLSPGLRALVMTRVSQRCDCAFCIDANgLRLAQRCG-SLDKVLAVATWQEADCFDAMERAA 123
Cdd:pfam02627   1 PELLAALTALAFGL-LWDGGLDPKTRELIALAVSAANGCAYCLDAH-TRAALKAGvTEEEIAEVLAWAAAYAGGPAARAA 78


                  ....*.
gi 506352238  124 LAYADA 129
Cdd:pfam02627  79 LAAAEE 84
 
Name Accession Description Interval E-value
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 45-180 7.66e-38

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 127.30  E-value: 7.66e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506352238  45 PRLFWLMALFVGYLeRRRATLSPGLRALVMTRVSQRCDCAFCIDANGLRLAQRCGSLDKVLAVATWQEADCFDAMERAAL 124
Cdd:COG2128    3 PELLKAFLALSGAL-MAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERIDALRAWRESPLFDPRERAAL 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 506352238 125 AYADAVSATPPQVSAALKAELRRHFDDCALTELTALVAFQNLSARFNAALDIPAQG 180
Cdd:COG2128   82 AFAEALTRTPGGVSDADVAALRAGFSDAEIVELVLAIALFNMSNRLNNALGTPPDP 137
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 65-177 4.97e-09

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 53.18  E-value: 4.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506352238   65 LSPGLRALVMTRVSQRCDCAFCIDANGLRLAQRCGSLDKVLAVATWQEADCFDAMERAALAYADAVSATPPQVSAALKAE 144
Cdd:TIGR01926  60 LSRAERELIAVVVSRANGCVYCAAVHGAALRQLSGDPDLADAVAVNFRDADLSPRERAMLDFAVKLTATPAKVNEADFAA 139

                          90       100       110
                  ....*....|....*....|....*....|....
gi 506352238  145 LRRH-FDDCALTELTALVAFQNLSARFNAALDIP 177
Cdd:TIGR01926 140 LRAAgFSDLDILDLIHSVAFFNWANRLMLALGEP 173
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 45-129 1.21e-05

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 41.91  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506352238   45 PRLFWLMALFVGYLeRRRATLSPGLRALVMTRVSQRCDCAFCIDANgLRLAQRCG-SLDKVLAVATWQEADCFDAMERAA 123
Cdd:pfam02627   1 PELLAALTALAFGL-LWDGGLDPKTRELIALAVSAANGCAYCLDAH-TRAALKAGvTEEEIAEVLAWAAAYAGGPAARAA 78


                  ....*.
gi 506352238  124 LAYADA 129
Cdd:pfam02627  79 LAAAEE 84
perox_Avi_7169 TIGR04030
alkylhydroperoxidase domain protein, Avi_7169 family; Members of this family represent a ...
 70-177 3.68e-04

alkylhydroperoxidase domain protein, Avi_7169 family; Members of this family represent a narrow clade that falls within a family of alkylhydroperoxidase-related proteins, fused to or adjacent to a sequence described by TIGR04029. These two partners occur almost always in the context of a putative FMN-dependent luciferase-like monooxygenase (LLM) (TIGR04027), and an ABC transporter in which TIGR04028 models the substrate-binding protein.


Pssm-ID: 188545  Cd Length: 185  Bit Score: 39.77  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506352238   70 RALVMTRVSQRCDCAFCIDANGLRLAQRCGSLDKV---LAVATwqEADCFDAMERAALAYADAVSATPPQVSAALKAELR 146
Cdd:TIGR04030  76 RELAATVTSRYNGCIYCASVHARKASQLSKRRDDVqrlLDVGP--GADLGSERWQAIIDAAAALSATPAAFNAAHVAALR 153

                          90       100       110
                  ....*....|....*....|....*....|..
gi 506352238  147 RH-FDDCALTELTALVAFQNLSARFNAALDIP 177
Cdd:TIGR04030 154 AQgLDDLAIVDLIQSAAFFNWANRLMLTLGEP 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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