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Conserved domains on  [gi|506355101|ref|WP_015874820|]
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MULTISPECIES: helix-turn-helix domain-containing protein [Klebsiella]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 14398448)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 30-125 3.08e-23

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 90.32  E-value: 3.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101  30 AISYQRGEADPPHHHVEGQLLFATRGVMLVQTESDRWVIPPQRALWLPPLHIHSYHLLSQTDLRAIYFSSSLIAECtsft 109
Cdd:cd06124    5 AADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAGL---- 80

                         90
                 ....*....|....*.
gi 506355101 110 kSQQVHVITATPLVKE 125
Cdd:cd06124   81 -PAEPCVLAVSPLLRE 95
HTH_18 pfam12833
Helix-turn-helix domain;
189-264 5.49e-18

Helix-turn-helix domain;


:

Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 76.09  E-value: 5.49e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506355101  189 LAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLAN--GVPIKQVAYQLGFSCPAAFTAAFRCILGATPRDY 264
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEY 78
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 30-125 3.08e-23

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 90.32  E-value: 3.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101  30 AISYQRGEADPPHHHVEGQLLFATRGVMLVQTESDRWVIPPQRALWLPPLHIHSYHLLSQTDLRAIYFSSSLIAECtsft 109
Cdd:cd06124    5 AADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAGL---- 80

                         90
                 ....*....|....*.
gi 506355101 110 kSQQVHVITATPLVKE 125
Cdd:cd06124   81 -PAEPCVLAVSPLLRE 95
HTH_18 pfam12833
Helix-turn-helix domain;
189-264 5.49e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 76.09  E-value: 5.49e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506355101  189 LAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLAN--GVPIKQVAYQLGFSCPAAFTAAFRCILGATPRDY 264
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEY 78
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-264 7.75e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 76.05  E-value: 7.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101   185 SLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLANG-VPIKQVAYQLGFSCPAAFTAAFRCILGATPRD 263
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   .
gi 506355101   264 Y 264
Cdd:smart00342  83 Y 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
17-264 1.43e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.82  E-value: 1.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101  17 APRHDEATGWSSTAISYQRGEADPPHHHVEGQLLFATRGVMLVQTESDRWVIPPQRALWLPPLHIHSYHLLSQTDLRAIY 96
Cdd:COG2207   15 ALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101  97 FSSSLIAECTSFTKSQQVHVITATPLVKELIAGLFSEDYARPSQRKIALLLLEILSEAPPLtmalpmpnderlfSAARSL 176
Cdd:COG2207   95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLL-------------LLLLLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 177 LVNQRWEASLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLANG-VPIKQVAYQLGFSCPAAFTAAFRC 255
Cdd:COG2207  162 LLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSRAFKK 241


                 ....*....
gi 506355101 256 ILGATPRDY 264
Cdd:COG2207  242 RFGVTPSEY 250
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 185-264 1.58e-15

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 74.81  E-value: 1.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 185 SLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLANG-VPIKQVAYQLGFSCPAAFTAAFRCILGATPRD 263
Cdd:COG4977  228 SVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLSIEEIAAACGFGSASHFRRAFRRRFGVSPSA 307


                 .
gi 506355101 264 Y 264
Cdd:COG4977  308 Y 308
ftrA PRK09393
transcriptional activator FtrA; Provisional
 162-264 2.65e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 62.67  E-value: 2.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 162 PMPNDER-----LFSAARSLLVNqrwEASLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLL-ANGVPIK 235
Cdd:PRK09393 211 PVASRESdrlgpLIDWMRAHLAE---PHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSID 287

                         90       100
                 ....*....|....*....|....*....
gi 506355101 236 QVAYQLGFSCPAAFTAAFRCILGATPRDY 264
Cdd:PRK09393 288 QIAERAGFGSEESLRHHFRRRAATSPAAY 316
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 40-151 4.45e-08

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 50.90  E-value: 4.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101   40 PPHHHVEGQLLFATRGVMLVQTESDRWVIPPQRALWLPPLHIHSYHLLSQTDL--RAIYFSSSLIAEC---TSFTKSQ-- 112
Cdd:pfam02311  17 PPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWryRWLYFEPELLERIladISILAGGpl 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 506355101  113 -QVHVITATPLVKELIAGLfsEDYARPSQRKIALLLLEIL 151
Cdd:pfam02311  97 pLLRDPELAALLRALFRLL--EEAGRSDDLLAEALLYQLL 134
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 30-125 3.08e-23

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 90.32  E-value: 3.08e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101  30 AISYQRGEADPPHHHVEGQLLFATRGVMLVQTESDRWVIPPQRALWLPPLHIHSYHLLSQTDLRAIYFSSSLIAECtsft 109
Cdd:cd06124    5 AADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAGL---- 80

                         90
                 ....*....|....*.
gi 506355101 110 kSQQVHVITATPLVKE 125
Cdd:cd06124   81 -PAEPCVLAVSPLLRE 95
HTH_18 pfam12833
Helix-turn-helix domain;
189-264 5.49e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 76.09  E-value: 5.49e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506355101  189 LAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLAN--GVPIKQVAYQLGFSCPAAFTAAFRCILGATPRDY 264
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEdtGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEY 78
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-264 7.75e-18

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 76.05  E-value: 7.75e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101   185 SLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLANG-VPIKQVAYQLGFSCPAAFTAAFRCILGATPRD 263
Cdd:smart00342   3 TLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTdLSVTEIALRVGFSSQSYFSRAFKKLFGVTPSE 82


                   .
gi 506355101   264 Y 264
Cdd:smart00342  83 Y 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
17-264 1.43e-17

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 79.82  E-value: 1.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101  17 APRHDEATGWSSTAISYQRGEADPPHHHVEGQLLFATRGVMLVQTESDRWVIPPQRALWLPPLHIHSYHLLSQTDLRAIY 96
Cdd:COG2207   15 ALLLLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101  97 FSSSLIAECTSFTKSQQVHVITATPLVKELIAGLFSEDYARPSQRKIALLLLEILSEAPPLtmalpmpnderlfSAARSL 176
Cdd:COG2207   95 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLL-------------LLLLLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 177 LVNQRWEASLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLANG-VPIKQVAYQLGFSCPAAFTAAFRC 255
Cdd:COG2207  162 LLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETdLSISEIAYELGFSSQSHFSRAFKK 241


                 ....*....
gi 506355101 256 ILGATPRDY 264
Cdd:COG2207  242 RFGVTPSEY 250
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 185-264 1.58e-15

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 74.81  E-value: 1.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 185 SLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLANG-VPIKQVAYQLGFSCPAAFTAAFRCILGATPRD 263
Cdd:COG4977  228 SVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTdLSIEEIAAACGFGSASHFRRAFRRRFGVSPSA 307


                 .
gi 506355101 264 Y 264
Cdd:COG4977  308 Y 308
ftrA PRK09393
transcriptional activator FtrA; Provisional
 162-264 2.65e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 62.67  E-value: 2.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 162 PMPNDER-----LFSAARSLLVNqrwEASLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLL-ANGVPIK 235
Cdd:PRK09393 211 PVASRESdrlgpLIDWMRAHLAE---PHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLeSSALSID 287

                         90       100
                 ....*....|....*....|....*....
gi 506355101 236 QVAYQLGFSCPAAFTAAFRCILGATPRDY 264
Cdd:PRK09393 288 QIAERAGFGSEESLRHHFRRRAATSPAAY 316
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 185-264 3.26e-11

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 62.76  E-value: 3.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 185 SLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLANGVPIKQVAYQLGFSCPAAFTAAFRCILGATPRDY 264
Cdd:COG2169  102 SLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAAYAAGFGSLSRFYEAFKKLLGMTPSAY 181
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
31-99 3.20e-08

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 50.23  E-value: 3.20e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 506355101  31 ISYQRGEADPPHHHVEGQLLFATRGVMLVQTESDRWVIPPQRALWLPPLHIHSYHLLSQTDLRAIYFSS 99
Cdd:COG1917   28 VTFEPGARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVLLVVFS 96
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 40-151 4.45e-08

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 50.90  E-value: 4.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101   40 PPHHHVEGQLLFATRGVMLVQTESDRWVIPPQRALWLPPLHIHSYHLLSQTDL--RAIYFSSSLIAEC---TSFTKSQ-- 112
Cdd:pfam02311  17 PPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWryRWLYFEPELLERIladISILAGGpl 96

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 506355101  113 -QVHVITATPLVKELIAGLfsEDYARPSQRKIALLLLEIL 151
Cdd:pfam02311  97 pLLRDPELAALLRALFRLL--EEAGRSDDLLAEALLYQLL 134
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
131-264 5.77e-06

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 46.51  E-value: 5.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 131 FSEDyarpsqrkIALLLLEIL----SEAPPLTMALPMpnDERLFSAARSLLVNQRWEASLSELAFMSAMSERTFSRLFMK 206
Cdd:PRK10572 153 YSEL--------LAMNLLERLllrcMEAIPESLHPPM--DPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQ 222

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 506355101 207 DTGFSFRTWKQRARI-CASLDLLANGVPIKQVAYQLGFSCPAAFTAAFRCILGATPRDY 264
Cdd:PRK10572 223 QLGISVLRWREDQRIsRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEF 281
PRK15435 PRK15435
bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;
164-264 1.30e-04

bifunctional DNA-binding transcriptional regulator/O6-methylguanine-DNA methyltransferase Ada;


Pssm-ID: 185333 [Multi-domain]  Cd Length: 353  Bit Score: 42.86  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 164 PNDERLFSAARSL-LVNQRWEASLSELAFMSAMSERTFSRLFMKDTGFSFRTWKQRARICASLDLLANGVPIKQVAYQLG 242
Cdd:PRK15435  79 PQQHRLDKITHACrLLEQETPVTLEALADQVAMSPFHLHRLFKATTGMTPKAWQQAWRARRLREALAKGESVTTSILNAG 158

                         90       100
                 ....*....|....*....|..
gi 506355101 243 FSCPAAFTAAFRCILGATPRDY 264
Cdd:PRK15435 159 FPDSSSYYRKADETLGMTAKQF 180
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 164-264 5.47e-04

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 40.78  E-value: 5.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506355101 164 PNDERLFSAARSLLVNQRWEASLSE--LAFMSAMSERTFSRLFMKDtGFSFRTWKQRARI---CASLDLLANGVPIKQVA 238
Cdd:PRK09685 193 PRRERQFQKVVALIDQSIQEEILRPewIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLdrcADDLRPAADDEKITSIA 271

                         90       100
                 ....*....|....*....|....*.
gi 506355101 239 YQLGFSCPAAFTAAFRCILGATPRDY 264
Cdd:PRK09685 272 YKWGFSDSSHFSTAFKQRFGVSPGEY 297
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 40-98 7.80e-04

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 37.46  E-value: 7.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 506355101  40 PPHHHVEG-QLLFATRGVMLVQTESDRWV-IPPQRALWLPPLHIHSYHLLSQTDLRAIYFS 98
Cdd:cd02208   13 PPHWHPEQdEIFYVLSGEGELTLDDGETVeLKAGDIVLIPPGVPHSFVNTSDEPAVFLVVS 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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