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Conserved domains on  [gi|506379259|ref|WP_015898978|]
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MULTISPECIES: rhodanese-like domain-containing protein [Persephonella]

Protein Classification

rhodanese-like domain-containing protein( domain architecture ID 10001806)

rhodanese-like domain-containing protein may have sulfurtransferase activity if an active site cysteine is present

CATH:  3.40.250.10
PubMed:  12151332|17454295

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PspE COG0607
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; ...
 12-116 1.28e-41

Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Rhodanese-related sulfurtransferase is part of the Pathway/BioSystem: Urea cycle


:

Pssm-ID: 440372 [Multi-domain]  Cd Length: 106  Bit Score: 132.78  E-value: 1.28e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  12 HISVNELKEKIDSgEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKG 91
Cdd:COG0607    5 EISPAELAELLES-EDAVLLDVREPEEFAAGHI--PGAINIPLGELAERLDELPKDKPIVVYCASGGRSAQAAALLRRAG 81

                         90       100
                 ....*....|....*....|....*
gi 506379259  92 FKNVKNVEGGILAWSEFIDPTVPQY 116
Cdd:COG0607   82 YTNVYNLAGGIEAWKAAGLPVEKGK 106
 
Name Accession Description Interval E-value
PspE COG0607
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; ...
 12-116 1.28e-41

Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Rhodanese-related sulfurtransferase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440372 [Multi-domain]  Cd Length: 106  Bit Score: 132.78  E-value: 1.28e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  12 HISVNELKEKIDSgEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKG 91
Cdd:COG0607    5 EISPAELAELLES-EDAVLLDVREPEEFAAGHI--PGAINIPLGELAERLDELPKDKPIVVYCASGGRSAQAAALLRRAG 81

                         90       100
                 ....*....|....*....|....*
gi 506379259  92 FKNVKNVEGGILAWSEFIDPTVPQY 116
Cdd:COG0607   82 YTNVYNLAGGIEAWKAAGLPVEKGK 106
RHOD_2 cd01528
Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes ...
 13-110 6.21e-32

Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains.


Pssm-ID: 238786 [Multi-domain]  Cd Length: 101  Bit Score: 108.25  E-value: 6.21e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSG-EDFILLDVREPQEYEFSRIREkeAMLIPLMKLP---AVIDKLPKDKPIYIICRSGNRSLQATLWLM 88
Cdd:cd01528    2 ISVAELAEWLADErEEPVLIDVREPEELEIAFLPG--FLHLPMSEIPersKELDSDNPDKDIVVLCHHGGRSMQVAQWLL 79

                         90       100
                 ....*....|....*....|..
gi 506379259  89 EKGFKNVKNVEGGILAWSEFID 110
Cdd:cd01528   80 RQGFENVYNLQGGIDAWSLEVD 101
PRK07878 PRK07878
molybdopterin biosynthesis-like protein MoeZ; Validated
 13-116 5.11e-26

molybdopterin biosynthesis-like protein MoeZ; Validated


Pssm-ID: 181156 [Multi-domain]  Cd Length: 392  Bit Score: 99.78  E-value: 5.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSGEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPA--VIDKLPKDKPIYIICRSGNRSLQATLWLMEK 90
Cdd:PRK07878 289 ITPRELKEWLDSGKKIALIDVREPVEWDIVHI--PGAQLIPKSEILSgeALAKLPQDRTIVLYCKTGVRSAEALAALKKA 366

                         90       100
                 ....*....|....*....|....*.
gi 506379259  91 GFKNVKNVEGGILAWSEFIDPTVPQY 116
Cdd:PRK07878 367 GFSDAVHLQGGVVAWAKQVDPSLPMY 392
RHOD smart00450
Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The ...
 24-111 1.71e-21

Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The the Cysteine containing enzymatically active version of the domain is also found in the CDC25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and stress proteins such as Senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions with a loss of the cysteine are also seen in Dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases. These are likely to play a role in protein interactions.


Pssm-ID: 197731 [Multi-domain]  Cd Length: 100  Bit Score: 81.74  E-value: 1.71e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259    24 SGEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPA--------------VIDKLPKDKPIYIICRSGNRSLQATLWLME 89
Cdd:smart00450   1 NDEKVVLLDVRSPEEYEGGHI--PGAVNIPLSELLDrrgeldilefeellKRLGLDKDKPVVVYCRSGNRSAKAAWLLRE 78

                           90       100
                   ....*....|....*....|..
gi 506379259    90 KGFKNVKNVEGGILAWSEFIDP 111
Cdd:smart00450  79 LGFKNVYLLDGGYKEWSAAGPP 100
Rhodanese pfam00581
Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single ...
 25-106 9.90e-20

Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.


Pssm-ID: 425764 [Multi-domain]  Cd Length: 92  Bit Score: 76.75  E-value: 9.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259   25 GEDFILLDVREPQEYEFSRIreKEAMLIP----------LMKLPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKGFKN 94
Cdd:pfam00581   3 DGKVVLIDVRPPEEYAKGHI--PGAVNVPlsslslpplpLLELLEKLLELLKDKPIVVYCNSGNRAAAAAALLKALGYKN 80

                          90
                  ....*....|..
gi 506379259   95 VKNVEGGILAWS 106
Cdd:pfam00581  81 VYVLDGGFEAWK 92
 
Name Accession Description Interval E-value
PspE COG0607
Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; ...
 12-116 1.28e-41

Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Rhodanese-related sulfurtransferase is part of the Pathway/BioSystem: Urea cycle


Pssm-ID: 440372 [Multi-domain]  Cd Length: 106  Bit Score: 132.78  E-value: 1.28e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  12 HISVNELKEKIDSgEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKG 91
Cdd:COG0607    5 EISPAELAELLES-EDAVLLDVREPEEFAAGHI--PGAINIPLGELAERLDELPKDKPIVVYCASGGRSAQAAALLRRAG 81

                         90       100
                 ....*....|....*....|....*
gi 506379259  92 FKNVKNVEGGILAWSEFIDPTVPQY 116
Cdd:COG0607   82 YTNVYNLAGGIEAWKAAGLPVEKGK 106
RHOD_2 cd01528
Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes ...
 13-110 6.21e-32

Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains.


Pssm-ID: 238786 [Multi-domain]  Cd Length: 101  Bit Score: 108.25  E-value: 6.21e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSG-EDFILLDVREPQEYEFSRIREkeAMLIPLMKLP---AVIDKLPKDKPIYIICRSGNRSLQATLWLM 88
Cdd:cd01528    2 ISVAELAEWLADErEEPVLIDVREPEELEIAFLPG--FLHLPMSEIPersKELDSDNPDKDIVVLCHHGGRSMQVAQWLL 79

                         90       100
                 ....*....|....*....|..
gi 506379259  89 EKGFKNVKNVEGGILAWSEFID 110
Cdd:cd01528   80 RQGFENVYNLQGGIDAWSLEVD 101
RHOD cd00158
Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese ...
 17-105 1.53e-31

Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and certain stress proteins such as senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions (no active site cysteine) are also seen in dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases, where they are believed to play a regulatory role in multidomain proteins.


Pssm-ID: 238089 [Multi-domain]  Cd Length: 89  Bit Score: 106.61  E-value: 1.53e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  17 ELKEKIDsGEDFILLDVREPQEYEFSRIreKEAMLIPLMKLP--AVIDKLPKDKPIYIICRSGNRSLQATLWLMEKGFKN 94
Cdd:cd00158    1 ELKELLD-DEDAVLLDVREPEEYAAGHI--PGAINIPLSELEerAALLELDKDKPIVVYCRSGNRSARAAKLLRKAGGTN 77

                         90
                 ....*....|.
gi 506379259  95 VKNVEGGILAW 105
Cdd:cd00158   78 VYNLEGGMLAW 88
PRK07878 PRK07878
molybdopterin biosynthesis-like protein MoeZ; Validated
 13-116 5.11e-26

molybdopterin biosynthesis-like protein MoeZ; Validated


Pssm-ID: 181156 [Multi-domain]  Cd Length: 392  Bit Score: 99.78  E-value: 5.11e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSGEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPA--VIDKLPKDKPIYIICRSGNRSLQATLWLMEK 90
Cdd:PRK07878 289 ITPRELKEWLDSGKKIALIDVREPVEWDIVHI--PGAQLIPKSEILSgeALAKLPQDRTIVLYCKTGVRSAEALAALKKA 366

                         90       100
                 ....*....|....*....|....*.
gi 506379259  91 GFKNVKNVEGGILAWSEFIDPTVPQY 116
Cdd:PRK07878 367 GFSDAVHLQGGVVAWAKQVDPSLPMY 392
RHOD_ThiF cd01526
Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ...
 13-116 1.17e-25

Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein 3 (MOCS3) of Homo sapiens. These rhodanese-like domains are found C-terminal of the ThiF and MoeZ_MoeB domains.


Pssm-ID: 238784 [Multi-domain]  Cd Length: 122  Bit Score: 92.76  E-value: 1.17e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSGEDFILLDVREPQEYE-----------FSRIREKEAMLIPLMKLPAVIDklpKDKPIYIICRSGNRSL 81
Cdd:cd01526   10 VSVKDYKNILQAGKKHVLLDVRPKVHFEicrlpeainipLSELLSKAAELKSLQELPLDND---KDSPIYVVCRRGNDSQ 86

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 506379259  82 QATLWLMEKGFK-NVKNVEGGILAWSEFIDPTVPQY 116
Cdd:cd01526   87 TAVRKLKELGLErFVRDIIGGLKAWADKVDPTFPLY 122
PRK07411 PRK07411
molybdopterin-synthase adenylyltransferase MoeB;
13-116 5.37e-22

molybdopterin-synthase adenylyltransferase MoeB;


Pssm-ID: 180967 [Multi-domain]  Cd Length: 390  Bit Score: 88.64  E-value: 5.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSG-EDFILLDVREPQEYEFSRIreKEAMLIPLMKL---PAV--IDKLPKDKPIYIICRSGNRSLQATLW 86
Cdd:PRK07411 284 MTVTELKALLDSGaDDFVLIDVRNPNEYEIARI--PGSVLVPLPDIengPGVekVKELLNGHRLIAHCKMGGRSAKALGI 361

                         90       100       110
                 ....*....|....*....|....*....|
gi 506379259  87 LMEKGFKNvKNVEGGILAWSEFIDPTVPQY 116
Cdd:PRK07411 362 LKEAGIEG-TNVKGGITAWSREVDPSVPQY 390
RHOD smart00450
Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The ...
 24-111 1.71e-21

Rhodanese Homology Domain; An alpha beta fold found duplicated in the Rhodanese protein. The the Cysteine containing enzymatically active version of the domain is also found in the CDC25 class of protein phosphatases and a variety of proteins such as sulfide dehydrogenases and stress proteins such as Senesence specific protein 1 in plants, PspE and GlpE in bacteria and cyanide and arsenate resistance proteins. Inactive versions with a loss of the cysteine are also seen in Dual specificity phosphatases, ubiquitin hydrolases from yeast and in sulfuryltransferases. These are likely to play a role in protein interactions.


Pssm-ID: 197731 [Multi-domain]  Cd Length: 100  Bit Score: 81.74  E-value: 1.71e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259    24 SGEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPA--------------VIDKLPKDKPIYIICRSGNRSLQATLWLME 89
Cdd:smart00450   1 NDEKVVLLDVRSPEEYEGGHI--PGAVNIPLSELLDrrgeldilefeellKRLGLDKDKPVVVYCRSGNRSAKAAWLLRE 78

                           90       100
                   ....*....|....*....|..
gi 506379259    90 KGFKNVKNVEGGILAWSEFIDP 111
Cdd:smart00450  79 LGFKNVYLLDGGYKEWSAAGPP 100
Rhodanese pfam00581
Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single ...
 25-106 9.90e-20

Rhodanese-like domain; Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.


Pssm-ID: 425764 [Multi-domain]  Cd Length: 92  Bit Score: 76.75  E-value: 9.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259   25 GEDFILLDVREPQEYEFSRIreKEAMLIP----------LMKLPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKGFKN 94
Cdd:pfam00581   3 DGKVVLIDVRPPEEYAKGHI--PGAVNVPlsslslpplpLLELLEKLLELLKDKPIVVYCNSGNRAAAAAALLKALGYKN 80

                          90
                  ....*....|..
gi 506379259   95 VKNVEGGILAWS 106
Cdd:pfam00581  81 VYVLDGGFEAWK 92
RHOD_Pyr_redox cd01524
Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus ...
 25-106 1.84e-17

Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar rhodanese-like domains found C-terminal of the pyridine nucleotide-disulphide oxidoreductase (Pyr-redox) domain and the Pyr-redox dimerization domain.


Pssm-ID: 238782 [Multi-domain]  Cd Length: 90  Bit Score: 71.14  E-value: 1.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  25 GEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKGFKnVKNVEGGILA 104
Cdd:cd01524   11 ADGVTLIDVRTPQEFEKGHI--KGAINIPLDELRDRLNELPKDKEIIVYCAVGLRGYIAARILTQNGFK-VKNLDGGYKT 87


                 ..
gi 506379259 105 WS 106
Cdd:cd01524   88 YS 89
GlpE_ST cd01444
GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain ...
 12-105 5.02e-17

GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a catalytically active cysteine.


Pssm-ID: 238721 [Multi-domain]  Cd Length: 96  Bit Score: 69.98  E-value: 5.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  12 HISVNELKEKIDSGEDFILLDVREPQEYEFSRIREKEAMLIPLMKLPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKG 91
Cdd:cd01444    1 RISVDELAELLAAGEAPVLLDVRDPASYAALPDHIPGAIHLDEDSLDDWLGDLDRDRPVVVYCYHGNSSAQLAQALREAG 80

                         90
                 ....*....|....
gi 506379259  92 FKNVKNVEGGILAW 105
Cdd:cd01444   81 FTDVRSLAGGFEAW 94
PRK08762 PRK08762
molybdopterin-synthase adenylyltransferase MoeB;
13-107 8.74e-17

molybdopterin-synthase adenylyltransferase MoeB;


Pssm-ID: 236337 [Multi-domain]  Cd Length: 376  Bit Score: 74.28  E-value: 8.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSGedFILLDVREPQEYEFSRIreKEAMLIPLMKLPAVI-DKLP-KDKPIYIICRSGNRSLQATLWLMEK 90
Cdd:PRK08762   5 ISPAEARARAAQG--AVLIDVREAHERASGQA--EGALRIPRGFLELRIeTHLPdRDREIVLICASGTRSAHAAATLREL 80

                         90
                 ....*....|....*..
gi 506379259  91 GFKNVKNVEGGILAWSE 107
Cdd:PRK08762  81 GYTRVASVAGGFSAWKD 97
Polysulfide_ST cd01447
Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as ...
 13-107 2.18e-13

Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a terminal electron acceptor. The active site contains the same conserved cysteine that is the catalytic residue in other Rhodanese Homology Domain proteins.


Pssm-ID: 238724 [Multi-domain]  Cd Length: 103  Bit Score: 60.90  E-value: 2.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSgEDFILLDVREPQEYEfSRIREKEAMLIPLMKLPAVIDK--------LPKDKPIYIICRSGNRSLQAT 84
Cdd:cd01447    1 LSPEDARALLGS-PGVLLVDVRDPRELE-RTGMIPGAFHAPRGMLEFWADPdspyhkpaFAEDKPFVFYCASGWRSALAG 78

                         90       100
                 ....*....|....*....|...
gi 506379259  85 LWLMEKGFKNVKNVEGGILAWSE 107
Cdd:cd01447   79 KTLQDMGLKPVYNIEGGFKDWKE 101
RHOD_HSP67B2 cd01519
Member of the Rhodanese Homology Domain superfamily. This CD includes the heat shock protein ...
 14-107 2.85e-12

Member of the Rhodanese Homology Domain superfamily. This CD includes the heat shock protein 67B2 of Drosophila melanogaster and other similar proteins, many of which are uncharacterized.


Pssm-ID: 238777 [Multi-domain]  Cd Length: 106  Bit Score: 58.05  E-value: 2.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  14 SVNELKEKIDSGEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPAV-------------IDKLPKDKPIYIICRSGNRS 80
Cdd:cd01519    2 SFEEVKNLPNPHPNKVLIDVREPEELKTGKI--PGAINIPLSSLPDAlalseeefekkygFPKPSKDKELIFYCKAGVRS 79

                         90       100
                 ....*....|....*....|....*..
gi 506379259  81 LQATLWLMEKGFKNVKNVEGGILAWSE 107
Cdd:cd01519   80 KAAAELARSLGYENVGNYPGSWLDWAA 106
RHOD_YceA cd01518
Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, ...
 11-107 3.60e-10

Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins.


Pssm-ID: 238776 [Multi-domain]  Cd Length: 101  Bit Score: 52.58  E-value: 3.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  11 IHISVNELKEKIDsGEDFILLDVREPQEYEFSRIreKEAMLIPLMK---LPAVID---KLPKDKPIYIICRSGNRSLQAT 84
Cdd:cd01518    2 TYLSPAEWNELLE-DPEVVLLDVRNDYEYDIGHF--KGAVNPDVDTfreFPFWLDenlDLLKGKKVLMYCTGGIRCEKAS 78

                         90       100
                 ....*....|....*....|...
gi 506379259  85 LWLMEKGFKNVKNVEGGILAWSE 107
Cdd:cd01518   79 AYLKERGFKNVYQLKGGILKYLE 101
RHOD_YgaP cd01527
Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, ...
 13-105 8.13e-10

Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases.


Pssm-ID: 238785 [Multi-domain]  Cd Length: 99  Bit Score: 51.72  E-value: 8.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSGEdfILLDVREPQEYEFSRIREkeAMLIPLMKLPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKGF 92
Cdd:cd01527    4 ISPNDACELLAQGA--VLVDIREPDEYLRERIPG--ARLVPLSQLESEGLPLVGANAIIFHCRSGMRTQQNAERLAAISA 79

                         90
                 ....*....|...
gi 506379259  93 KNVKNVEGGILAW 105
Cdd:cd01527   80 GEAYVLEGGLDAW 92
PRK00142 PRK00142
rhodanese-related sulfurtransferase;
12-107 1.70e-09

rhodanese-related sulfurtransferase;


Pssm-ID: 234663 [Multi-domain]  Cd Length: 314  Bit Score: 53.31  E-value: 1.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  12 HISVNELKEKIDSgEDFILLDVREPQEYEFSRIreKEAMLIPlMK-----LPAVIDKL--PKDKPIYIICRSGNRSLQAT 84
Cdd:PRK00142 113 YLKPKEVNELLDD-PDVVFIDMRNDYEYEIGHF--ENAIEPD-IEtfrefPPWVEENLdpLKDKKVVMYCTGGIRCEKAS 188

                         90       100
                 ....*....|....*....|...
gi 506379259  85 LWLMEKGFKNVKNVEGGILAWSE 107
Cdd:PRK00142 189 AWMKHEGFKEVYQLEGGIITYGE 211
RHOD_Lact_B cd01523
Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with ...
 13-107 4.25e-09

Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain.


Pssm-ID: 238781 [Multi-domain]  Cd Length: 100  Bit Score: 49.80  E-value: 4.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSGEDFILLDVREPQEYEFSRIREKeaMLIPLMKLP--------AVIDKLPKDKPIYIICRSGNRSLQAT 84
Cdd:cd01523    1 LDPEDLYARLLAGQPLFILDVRNESDYERWKIDGE--NNTPYFDPYfdfleieeDILDQLPDDQEVTVICAKEGSSQFVA 78

                         90       100
                 ....*....|....*....|...
gi 506379259  85 LWLMEKGFKnVKNVEGGILAWSE 107
Cdd:cd01523   79 ELLAERGYD-VDYLAGGMKAWSE 100
glpE PRK00162
thiosulfate sulfurtransferase GlpE;
12-105 4.37e-09

thiosulfate sulfurtransferase GlpE;


Pssm-ID: 178908 [Multi-domain]  Cd Length: 108  Bit Score: 50.02  E-value: 4.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  12 HISVNELKEKIDSGeDFILLDVREPQEYEFSRIreKEAMLIPLMKLPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKG 91
Cdd:PRK00162   6 CINVEQAHQKLQEG-GAVLVDIRDPQSFAMGHA--PGAFHLTNDSLGAFMRQADFDTPVMVMCYHGNSSQGAAQYLLQQG 82

                         90
                 ....*....|....
gi 506379259  92 FKNVKNVEGGILAW 105
Cdd:PRK00162  83 FDVVYSIDGGFEAW 96
RHOD_1 cd01522
Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative ...
 57-100 4.38e-09

Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins.


Pssm-ID: 238780 [Multi-domain]  Cd Length: 117  Bit Score: 50.02  E-value: 4.38e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 506379259  57 LPAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKGFKNVKNV-EG 100
Cdd:cd01522   54 LAELEEKVGKDRPVLLLCRSGNRSIAAAEAAAQAGFTNVYNVlEG 98
PLN02160 PLN02160
thiosulfate sulfurtransferase
 11-105 2.29e-08

thiosulfate sulfurtransferase


Pssm-ID: 177819 [Multi-domain]  Cd Length: 136  Bit Score: 48.93  E-value: 2.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  11 IHISVNELKEKIDSGEDFilLDVREPQEYEFSRIREKEAMLIPLMK------------LPAVIDKLPKDKPIYIICRSGN 78
Cdd:PLN02160  15 VSVDVSQAKTLLQSGHQY--LDVRTQDEFRRGHCEAAKIVNIPYMLntpqgrvknqefLEQVSSLLNPADDILVGCQSGA 92

                         90       100
                 ....*....|....*....|....*..
gi 506379259  79 RSLQATLWLMEKGFKNVKNVEGGILAW 105
Cdd:PLN02160  93 RSLKATTELVAAGYKKVRNKGGGYLAW 119
PRK05597 PRK05597
molybdopterin biosynthesis protein MoeB; Validated
 26-107 4.49e-08

molybdopterin biosynthesis protein MoeB; Validated


Pssm-ID: 235526 [Multi-domain]  Cd Length: 355  Bit Score: 49.49  E-value: 4.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  26 EDFILLDVREPQEYEFSRIreKEAMLIPLMKL--PAVIDKLPKDKPIYIICRSGNRSLQATLWLMEKGFKNVKNVEGGIL 103
Cdd:PRK05597 273 DGVTLIDVREPSEFAAYSI--PGAHNVPLSAIreGANPPSVSAGDEVVVYCAAGVRSAQAVAILERAGYTGMSSLDGGIE 350


                 ....
gi 506379259 104 AWSE 107
Cdd:PRK05597 351 GWLD 354
TST_Repeat_2 cd01449
Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of ...
 13-107 8.81e-08

Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue.


Pssm-ID: 238726 [Multi-domain]  Cd Length: 118  Bit Score: 46.86  E-value: 8.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSGeDFILLDVREPQEY----------------------EFSRIREKEAMLIPLMKLPAVIDKLPK--DK 68
Cdd:cd01449    1 VTAEEVLANLDSG-DVQLVDARSPERFrgevpeprpglrsghipgavniPWTSLLDEDGTFKSPEELRALFAALGItpDK 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 506379259  69 PIYIICRSGNRSlqATLWLM--EKGFKNVKNVEGGilaWSE 107
Cdd:cd01449   80 PVIVYCGSGVTA--CVLLLAleLLGYKNVRLYDGS---WSE 115
SseA COG2897
3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion ...
 13-114 2.62e-07

3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism];


Pssm-ID: 442142 [Multi-domain]  Cd Length: 262  Bit Score: 47.09  E-value: 2.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  13 ISVNELKEKIDSGeDFILLDVREPQEY--------------------EFSRIREKEAMLIPLMKLPAVIDKL--PKDKPI 70
Cdd:COG2897  140 ADADEVLAALGDP-DAVLVDARSPERYrgevepidpraghipgavnlPWTDLLDEDGTFKSAEELRALFAALgiDPDKPV 218

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 506379259  71 YIICRSGNRSlqATLWL-MEK-GFKNVKNVEGGilaWSEFI-DPTVP 114
Cdd:COG2897  219 ITYCGSGVRA--AHTWLaLELlGYPNVRLYDGS---WSEWGsDPDLP 260
TrhO COG1054
tRNA U34 5'-hydroxylase TrhO, rhodanese family [Translation, ribosomal structure and ...
 12-103 1.70e-06

tRNA U34 5'-hydroxylase TrhO, rhodanese family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440674 [Multi-domain]  Cd Length: 304  Bit Score: 44.75  E-value: 1.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  12 HISVNELKEKIDsGEDFILLDVREPQEYE---FSR-I-------REkeamliplmkLPAVIDKLP---KDKPIYIICRSG 77
Cdd:COG1054  112 YLSPEEWNALIE-DPDVVVIDTRNDYEVEigtFKGaIdpdtdtfRE----------FPEWVEENLddlKDKKVAMYCTGG 180

                         90       100
                 ....*....|....*....|....*.
gi 506379259  78 NRSLQATLWLMEKGFKNVKNVEGGIL 103
Cdd:COG1054  181 IRCEKASAYLKEQGFEEVYQLEGGIL 206
RHOD_PspE2 cd01521
Member of the Rhodanese Homology Domain superfamily. This CD includes the putative ...
 24-107 5.53e-06

Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins.


Pssm-ID: 238779 [Multi-domain]  Cd Length: 110  Bit Score: 41.95  E-value: 5.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  24 SGEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPA-VIDKLPKDKPIYIICRS--GNRSLQATLWLMEKGFKnVKNVEG 100
Cdd:cd01521   22 GKPDFVLVDVRSAEAYARGHV--PGAINLPHREICEnATAKLDKEKLFVVYCDGpgCNGATKAALKLAELGFP-VKEMIG 98


                 ....*..
gi 506379259 101 GILAWSE 107
Cdd:cd01521   99 GLDWWKR 105
4RHOD_Repeats cd01529
Member of the Rhodanese Homology Domain superfamily. This CD includes putative ...
 30-105 6.50e-06

Member of the Rhodanese Homology Domain superfamily. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. Only the second and most of the fourth repeats contain the putative catalytic Cys residue. This CD aligns the 1st , 2nd, 3rd, and 4th repeats.


Pssm-ID: 238787 [Multi-domain]  Cd Length: 96  Bit Score: 41.51  E-value: 6.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  30 LLDVREPQEYEFSRIREKEAmlIPLMKLPAVIDKLP------KDKPIYIICRSGNRSLQATLWLMEKGFKNVKNVEGGIL 103
Cdd:cd01529   15 LLDVRAEDEYAAGHLPGKRS--IPGAALVLRSQELQaleapgRATRYVLTCDGSLLARFAAQELLALGGKPVALLDGGTS 92


                 ..
gi 506379259 104 AW 105
Cdd:cd01529   93 AW 94
4RHOD_Repeat_2 cd01533
Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative ...
 12-105 7.84e-06

Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic Cys residue.


Pssm-ID: 238791 [Multi-domain]  Cd Length: 109  Bit Score: 41.68  E-value: 7.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  12 HISVNELKEKIDSGEDFILLDVREPQEYEFSRIreKEAMLIPLMKLPAVIDKL-PKDK-PIYIICRSGNRSLQATLWLME 89
Cdd:cd01533   11 SVSADELAALQARGAPLVVLDGRRFDEYRKMTI--PGSVSCPGAELVLRVGELaPDPRtPIVVNCAGRTRSIIGAQSLIN 88

                         90
                 ....*....|....*..
gi 506379259  90 KGFKN-VKNVEGGILAW 105
Cdd:cd01533   89 AGLPNpVAALRNGTQGW 105
PRK05320 PRK05320
rhodanese superfamily protein; Provisional
 18-107 1.77e-05

rhodanese superfamily protein; Provisional


Pssm-ID: 235405 [Multi-domain]  Cd Length: 257  Bit Score: 41.94  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506379259  18 LKEKIDSGED-----FILLDVREPQEYEFSRIREkeAMLIPLMK---LPAVI----DKLpKDKPIYIICRSGNRSLQATL 85
Cdd:PRK05320 117 LKRWLDQGHDdagrpVVMLDTRNAFEVDVGTFDG--ALDYRIDKfteFPEALaahrADL-AGKTVVSFCTGGIRCEKAAI 193

                         90       100
                 ....*....|....*....|..
gi 506379259  86 WLMEKGFKNVKNVEGGILAWSE 107
Cdd:PRK05320 194 HMQEVGIDNVYQLEGGILKYFE 215
COG3453 COG3453
Predicted phosphohydrolase, protein tyrosine phosphatase (PTP) superfamily, DUF442 family ...
 59-88 7.22e-03

Predicted phosphohydrolase, protein tyrosine phosphatase (PTP) superfamily, DUF442 family [General function prediction only];


Pssm-ID: 442676 [Multi-domain]  Cd Length: 125  Bit Score: 33.65  E-value: 7.22e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 506379259  59 AVIDKLPKdkPIYIICRSGNRSlqATLWLM 88
Cdd:COG3453   79 AALAAAPG--PVLAHCRSGTRS--SALWAL 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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