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Conserved domains on  [gi|506991095|ref|WP_016081689|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Bacillus cereus group]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
27-145 2.00e-12

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 60.37  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506991095  27 KSSEFTHLEQHVVEYIAQQKvPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVDKRAILISLTEKAEKV---HY 103
Cdd:COG1846   32 AELGLTPAQFRVLAALAEAG-GLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALleeAR 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 506991095 104 ERWKQIYNNFtvnLEKLSEEDRRDLTyglyktnTMLSKMLNN 145
Cdd:COG1846  111 PALEALLAEL---LAGLSEEELEALL-------RLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
27-145 2.00e-12

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 60.37  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506991095  27 KSSEFTHLEQHVVEYIAQQKvPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVDKRAILISLTEKAEKV---HY 103
Cdd:COG1846   32 AELGLTPAQFRVLAALAEAG-GLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALleeAR 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 506991095 104 ERWKQIYNNFtvnLEKLSEEDRRDLTyglyktnTMLSKMLNN 145
Cdd:COG1846  111 PALEALLAEL---LAGLSEEELEALL-------RLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
35-125 4.42e-10

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 53.37  E-value: 4.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506991095    35 EQHVVEYIAQQKVPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVDKRAILISLTEKAEKVH---YERWKQIYN 111
Cdd:smart00347  11 TQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIeqlLEARSETLA 90

                           90
                   ....*....|....
gi 506991095   112 NFtvnLEKLSEEDR 125
Cdd:smart00347  91 EL---LAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-89 1.05e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 40.65  E-value: 1.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 506991095   38 VVEYIAQQKvPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVDKRA 89
Cdd:pfam12802  10 VLLALARNP-GLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 8-112 6.89e-04

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 36.85  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506991095    8 NEYMNLLLNMSGTFKLLsEKSSEFTHLEQHVVEYIA---QQKVPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDM 84
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYL-KKEFNLSLEELLILYYLGkleNNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSE 79

                          90       100
                  ....*....|....*....|....*...
gi 506991095   85 VDKRAILISLTEKAEKVHYERWKQIYNN 112
Cdd:TIGR01889  80 DDERKVIISINKEQRSKIESLISEIEQI 107
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
27-145 2.00e-12

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 60.37  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506991095  27 KSSEFTHLEQHVVEYIAQQKvPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVDKRAILISLTEKAEKV---HY 103
Cdd:COG1846   32 AELGLTPAQFRVLAALAEAG-GLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRLTEKGRALleeAR 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 506991095 104 ERWKQIYNNFtvnLEKLSEEDRRDLTyglyktnTMLSKMLNN 145
Cdd:COG1846  111 PALEALLAEL---LAGLSEEELEALL-------RLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
35-125 4.42e-10

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 53.37  E-value: 4.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506991095    35 EQHVVEYIAQQKVPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVDKRAILISLTEKAEKVH---YERWKQIYN 111
Cdd:smart00347  11 TQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIeqlLEARSETLA 90

                           90
                   ....*....|....
gi 506991095   112 NFtvnLEKLSEEDR 125
Cdd:smart00347  91 EL---LAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-89 1.05e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 40.65  E-value: 1.05e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 506991095   38 VVEYIAQQKvPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVDKRA 89
Cdd:pfam12802  10 VLLALARNP-GLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_27 pfam13463
Winged helix DNA-binding domain;
31-98 2.64e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 37.27  E-value: 2.64e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 506991095   31 FTHLEQHVVEYIAQQKVPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVDKRAILISLTEKA 98
Cdd:pfam13463   1 LTRLEALILHNIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
29-101 5.55e-04

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 37.49  E-value: 5.55e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 506991095  29 SEFTHLEQHVVEYIA---QQKVPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVdkrailISLTEKAEKV 101
Cdd:COG1321    2 MMLSESEEDYLKAIYelsEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGG------ITLTEEGREL 71
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 8-112 6.89e-04

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 36.85  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 506991095    8 NEYMNLLLNMSGTFKLLsEKSSEFTHLEQHVVEYIA---QQKVPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDM 84
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYL-KKEFNLSLEELLILYYLGkleNNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSE 79

                          90       100
                  ....*....|....*....|....*...
gi 506991095   85 VDKRAILISLTEKAEKVHYERWKQIYNN 112
Cdd:TIGR01889  80 DDERKVIISINKEQRSKIESLISEIEQI 107
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-90 8.88e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 35.60  E-value: 8.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 506991095   31 FTHLEQHVVEYIAQQKvPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQDMVDKRAI 90
Cdd:pfam01047   1 LTLTQFHILRILYEHG-PLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 30-100 6.23e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 33.73  E-value: 6.23e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 506991095  30 EFTHLEQHVVEYIAQQKVPVNLKMIASYLNIPKQQLSVTVRNLEQNGYIIKKQdmvDKRAILISLTEKAEK 100
Cdd:COG2512   12 ELLEDERRVLELLRENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKER---VGRENVVELPEDEPE 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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