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Conserved domains on  [gi|507051323|ref|WP_016122316|]
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MULTISPECIES: MFS transporter [Bacillus]

Protein Classification

MFS transporter( domain architecture ID 13022956)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 17-422 2.30e-94

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 292.54  E-value: 2.30e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  17 GFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSIS 96
Cdd:cd17321    4 AVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  97 LETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIA 176
Cdd:cd17321   84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 177 CVLVlilfkesydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekkskypilpl 256
Cdd:cd17321  164 LLLA---------------------------------------------------------------------------- 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 257 wlfnnRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGML 336
Cdd:cd17321  168 -----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 337 LLAVTTYSFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALLNN 416
Cdd:cd17321  243 LTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTA 322


                 ....*.
gi 507051323 417 QLESQL 422
Cdd:cd17321  323 GLSANL 328
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 17-422 2.30e-94

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 292.54  E-value: 2.30e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  17 GFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSIS 96
Cdd:cd17321    4 AVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  97 LETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIA 176
Cdd:cd17321   84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 177 CVLVlilfkesydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekkskypilpl 256
Cdd:cd17321  164 LLLA---------------------------------------------------------------------------- 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 257 wlfnnRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGML 336
Cdd:cd17321  168 -----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 337 LLAVTTYSFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALLNN 416
Cdd:cd17321  243 LTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTA 322


                 ....*.
gi 507051323 417 QLESQL 422
Cdd:cd17321  323 GLSANL 328
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 9-416 1.54e-76

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 249.99  E-value: 1.54e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323    9 FALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   89 LLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFI 168
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  169 NIPIGLIACVLVLILFKESYDELSeKKIDWLGVLLSSLFLFTLVLALLKVNDDSW-NKEYIILLFVISIISFISFINIEK 247
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAAS-ENFDFLGLLLLSVGLGSLLYGLSEGPERGWfDSNEILILSITGLVAIIAFVVWEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  248 KSKYPILPLWLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGS 327
Cdd:TIGR00711 241 TDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  328 RWIGMAGMLLLAVTTYSFT-TMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:TIGR00711 321 RKLVTIGLILYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIG 400

                         410
                  ....*....|
gi 507051323  407 VAVLVALLNN 416
Cdd:TIGR00711 401 TALITTILTN 410
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-405 2.77e-63

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 210.99  E-value: 2.77e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  89 LLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFI 168
Cdd:COG2814   90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 169 NIPIGLIACVLVLILFKESYDELSEKKIDWLGVllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekk 248
Cdd:COG2814  170 NAVLALLALLLLLRLLPESRPAARARLRGSLRE----------------------------------------------- 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 249 skypilplwLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSR 328
Cdd:COG2814  203 ---------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507051323 329 WIGMAGMLLLAVttySFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSIL 405
Cdd:COG2814  274 RLLLIGLLLLAL---GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
14-406 6.61e-46

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 164.51  E-value: 6.61e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   14 LISGFFMAILDSNIVNIVLPE-MTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCG 92
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   93 LSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPI 172
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  173 GLIACVLVLILFKESYDELSEKkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniEKKSKYP 252
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP---------------------------------------------------AEEARLS 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  253 ILPLWLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGM 332
Cdd:pfam07690 190 LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507051323  333 AGMLLLAVTTYSFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
PRK10504 PRK10504
putative transporter; Provisional
 17-345 1.03e-39

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 150.65  E-value: 1.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  17 GFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSIS 96
Cdd:PRK10504  18 GFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGT 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  97 LETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKqgiiggIMGAF------GGLAAAIGPALGGILSDQLSWKWIFFINI 170
Cdd:PRK10504  98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQ------YMAAMtfvtlpGQVGPLLGPALGGLLVEYASWHWIFLINI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 171 PIGLIACVLVLILFKESydELSEKKIDWLGVLLSSLFLFTLVLALLKVNDDSWNKEYIILLFVISIISFISFINIEKKSK 250
Cdd:PRK10504 172 PVGIIGAIATLMLMPNY--TMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNN 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 251 YPILPLWLFNNRQFSVGNL--LLFIVGMGMMNiiFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSR 328
Cdd:PRK10504 250 RALFSLKLFRTRTFSLGLAgsFAGRIGSGMLP--FMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYR 327

                        330
                 ....*....|....*..
gi 507051323 329 WIGMAGMLLLAVTTYSF 345
Cdd:PRK10504 328 RVLVATTLGLALVSLLF 344
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 17-422 2.30e-94

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 292.54  E-value: 2.30e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  17 GFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSIS 96
Cdd:cd17321    4 AVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  97 LETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIA 176
Cdd:cd17321   84 LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 177 CVLVlilfkesydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekkskypilpl 256
Cdd:cd17321  164 LLLA---------------------------------------------------------------------------- 167

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 257 wlfnnRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGML 336
Cdd:cd17321  168 -----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 337 LLAVTTYSFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALLNN 416
Cdd:cd17321  243 LTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTA 322


                 ....*.
gi 507051323 417 QLESQL 422
Cdd:cd17321  323 GLSANL 328
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 14-417 2.00e-81

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 259.43  E-value: 2.00e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  14 LISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGL 93
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  94 SISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIG 173
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 174 LIACVLVlilfkesydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekkskyPI 253
Cdd:cd17503  161 ILALLLA-----------------------------------------------------------------------PL 169

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 254 LPLWLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMA 333
Cdd:cd17503  170 LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 334 GMLLLAVTTYSFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVAL 413
Cdd:cd17503  250 GLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329


                 ....
gi 507051323 414 LNNQ 417
Cdd:cd17503  330 LTNR 333
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 9-416 1.54e-76

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 249.99  E-value: 1.54e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323    9 FALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   89 LLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFI 168
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  169 NIPIGLIACVLVLILFKESYDELSeKKIDWLGVLLSSLFLFTLVLALLKVNDDSW-NKEYIILLFVISIISFISFINIEK 247
Cdd:TIGR00711 162 NVPIGIIVVVVAFFILPRDKPAAS-ENFDFLGLLLLSVGLGSLLYGLSEGPERGWfDSNEILILSITGLVAIIAFVVWEL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  248 KSKYPILPLWLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGS 327
Cdd:TIGR00711 241 TDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  328 RWIGMAGMLLLAVTTYSFT-TMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:TIGR00711 321 RKLVTIGLILYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIG 400

                         410
                  ....*....|
gi 507051323  407 VAVLVALLNN 416
Cdd:TIGR00711 401 TALITTILTN 410
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
9-405 2.77e-63

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 210.99  E-value: 2.77e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  89 LLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFI 168
Cdd:COG2814   90 LLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 169 NIPIGLIACVLVLILFKESYDELSEKKIDWLGVllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekk 248
Cdd:COG2814  170 NAVLALLALLLLLRLLPESRPAARARLRGSLRE----------------------------------------------- 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 249 skypilplwLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSR 328
Cdd:COG2814  203 ---------LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR 273

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507051323 329 WIGMAGMLLLAVttySFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSIL 405
Cdd:COG2814  274 RLLLIGLLLLAL---GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 14-412 4.78e-53

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 183.53  E-value: 4.78e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  14 LISGFFMAILDSNIVNIVLPEMTISFNtSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGL 93
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  94 SISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIG 173
Cdd:cd17502   80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 174 LIACVLVlilfkesydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekkskypi 253
Cdd:cd17502  160 GLALALL------------------------------------------------------------------------- 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 254 lplwlfnnRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIfSMIVTTIMTPIATKKGSR--WIG 331
Cdd:cd17502  167 --------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLII-GLVIGSIISGALISKTGRykPLI 237

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 332 MAGMLLLAVTTYSFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLV 411
Cdd:cd17502  238 VIGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITD 317


                 .
gi 507051323 412 A 412
Cdd:cd17502  318 V 318
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 7-183 4.45e-50

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 174.23  E-value: 4.45e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   7 HSFALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTI 86
Cdd:COG0477   12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  87 SSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIF 166
Cdd:COG0477   92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171

                        170
                 ....*....|....*..
gi 507051323 167 FINIPIGLIACVLVLIL 183
Cdd:COG0477  172 LINAPLGLLALVLRLRL 188
MFS_1 pfam07690
Major Facilitator Superfamily;
14-406 6.61e-46

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 164.51  E-value: 6.61e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   14 LISGFFMAILDSNIVNIVLPE-MTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCG 92
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   93 LSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPI 172
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  173 GLIACVLVLILFKESYDELSEKkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniEKKSKYP 252
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKP---------------------------------------------------AEEARLS 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  253 ILPLWLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGM 332
Cdd:pfam07690 190 LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507051323  333 AGMLLLAVTTYSFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 31-414 2.06e-42

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 155.81  E-value: 2.06e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  31 VLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGIS 110
Cdd:cd17504   18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 111 AAiIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVlilfkesyde 190
Cdd:cd17504   98 GA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALV---------- 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 191 lsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekkskyPILPLWLFNNRQFSVGNLL 270
Cdd:cd17504  167 -------------------------------------------------------------PLIDLRLLRRRNVLLANIT 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 271 LFIVGMGMMNIIFLLSFFLTQVQ----GISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYSFT 346
Cdd:cd17504  186 ALLAGFGMFMVFQLLPQLLQLPTptgfGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLA 265

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507051323 347 TMSTdfTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALL 414
Cdd:cd17504  266 LLHS--SLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 14-406 3.18e-42

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 155.43  E-value: 3.18e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  14 LISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGL 93
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  94 SISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIG 173
Cdd:cd17325   81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 174 LIACVLVLILFKESYDELSEKKIDWLGVLLSSlflftlvlallkvnddswnkeyiillfvisiisfisfiniekkskypi 253
Cdd:cd17325  161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGL------------------------------------------------ 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 254 lpLWLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMA 333
Cdd:cd17325  193 --RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILI 270

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507051323 334 GMLLLAVTTYSFTTMSTdFTSLdyIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:cd17325  271 GLLLSAVALLLLPLATS-FWLL--LLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
PRK10504 PRK10504
putative transporter; Provisional
 17-345 1.03e-39

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 150.65  E-value: 1.03e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  17 GFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSIS 96
Cdd:PRK10504  18 GFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGT 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  97 LETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKqgiiggIMGAF------GGLAAAIGPALGGILSDQLSWKWIFFINI 170
Cdd:PRK10504  98 LNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQ------YMAAMtfvtlpGQVGPLLGPALGGLLVEYASWHWIFLINI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 171 PIGLIACVLVLILFKESydELSEKKIDWLGVLLSSLFLFTLVLALLKVNDDSWNKEYIILLFVISIISFISFINIEKKSK 250
Cdd:PRK10504 172 PVGIIGAIATLMLMPNY--TMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNN 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 251 YPILPLWLFNNRQFSVGNL--LLFIVGMGMMNiiFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSR 328
Cdd:PRK10504 250 RALFSLKLFRTRTFSLGLAgsFAGRIGSGMLP--FMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYR 327

                        330
                 ....*....|....*..
gi 507051323 329 WIGMAGMLLLAVTTYSF 345
Cdd:PRK10504 328 RVLVATTLGLALVSLLF 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
9-414 7.18e-38

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 143.09  E-value: 7.18e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  89 LLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFI 168
Cdd:COG2271   90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 169 NIPIGLIACVLVLILfkesydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekk 248
Cdd:COG2271  170 LGLPGLLLALLRFWL----------------------------------------------------------------- 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 249 skypilpLWLFNnrqfsvgnlllFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSR 328
Cdd:COG2271  185 -------LALAY-----------FLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR 246

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 329 --WIGMAGMLLLAVTTYSFTTMSTdfTSLDYIWrVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:COG2271  247 rkLVLAIGLLLAALALLLLALLPS--PALAIAL-LFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALG 323


                 ....*...
gi 507051323 407 VAVLVALL 414
Cdd:COG2271  324 PLLVGYLL 331
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 12-422 7.12e-34

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 135.06  E-value: 7.12e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  12 FALISGFFMAILDSNIVNIVLPEMTISFNTSVEhISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLC 91
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSN-STWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  92 GLSISLETIVLFRVIQGISAAIIVPVAmPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGIL--SDQLSWKWIFFIN 169
Cdd:cd06179   80 GTAKSVNMLIGGQALIGIGAGTQGLGA-AVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYIN 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 170 IPIGLIACVLVLILF--KESYDELSE------KKIDWLGVLLSSLFLFTLVLALLKV-NDDSWNKEYIILLFVISIISFI 240
Cdd:cd06179  159 AIFNALALILLFFFYhpPPRPQLHGSstrqklKRLDWVGLFLLIAGLVLFLLGLSWGgNPYPWSSAHVIAPLVIGGVLLI 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 241 SFINIE-KKSKYPILPLWLF-NNRQFSvgnLLLFIVGMGMMNIIFLLSFFLTQVQGISE---LKAGLIISVLAIFSMIVT 315
Cdd:cd06179  239 AFGLYEwKGTKDGLLPPRLLfRGRNFA---LILIVAFVEGMIFYSLNIFWPQQISLLFTtdpLKAGLYQLPFGLGTLFGA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 316 TIMTPIATK-KGSRW-------IGMAGMLLLAVTTYSFTTMSTDFtsldyiwrVAVGGVGTGCTLAPISTTAILSVPVNK 387
Cdd:cd06179  316 ILAGLLLTKiKHIKWqlvagfvLFTAFLALLALITPDNKALAIAF--------SVLAGIGIGGPLVLAIVIVQLSVPPED 387

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 507051323 388 SGMASSITNISRTIGSILGVAVLVALLNNQLESQL 422
Cdd:cd06179  388 IGTASGLLGSARALGGAVGTAIFTSILSNRLSKNL 422
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 11-406 7.17e-34

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 132.31  E-value: 7.17e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLL 90
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  91 CGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDqLSWKWIFFINI 170
Cdd:cd17474   81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 171 PIGLIACVLVLILFKESydelSEKKIDWLGVLLSSLFLFTLVLALLKVnddswnkeYIIllfvisiisfisfiniekksk 250
Cdd:cd17474  160 ALIPVAFLAILFLLPEP----KEKAKSSSATKLRDLKKALRGRGLLTF--------LVS--------------------- 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 251 ypilplwlfnnrqFSVGNLLLFIvgmgmmnIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKK-GSRW 329
Cdd:cd17474  207 -------------AFLYFFLYFA-------FLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRfGARR 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 330 IGMAGMLLLAVTTYSFttmstdFTSLDYIWRV---AVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:cd17474  267 ILVIGLLLYALSLLLL------GFVPSLALLLiaiVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 14-415 2.78e-31

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 124.85  E-value: 2.78e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  14 LISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGL 93
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  94 SISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQL--SWKWIFFINIP 171
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 172 IGLIACVLVLILFKESYDELSEKKIdwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniEKKSKY 251
Cdd:cd06174  161 LALLAAILLLLVVPDPPESARAKNE-------------------------------------------------EASSKS 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 252 PILPLW-LFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWI 330
Cdd:cd06174  192 VLKLLKrVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 331 GMAGMLLLAVTTYSFTTMSTDFTSLdyIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVL 410
Cdd:cd06174  272 LLLIGLLLMALGLALLLLAPSLLLL--LLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA 349


                 ....*
gi 507051323 411 VALLN 415
Cdd:cd06174  350 GFLLA 354
PRK14995 PRK14995
SmvA family efflux MFS transporter;
23-414 1.64e-30

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 124.84  E-value: 1.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  23 LDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVL 102
Cdd:PRK14995  20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIA 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 103 FRVIQGISAAIIVPVAMPLGLELVPKEKQGIIG-GIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVL 181
Cdd:PRK14995 100 TRALLAIGAAMIVPATLAGIRATFTEEKQRNMAlGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 182 ILFKESyDELSEKKIDWLGVLLSSLFLFTLVLAL---LKVNDDSWnkeYIILLFVISIISFISFINIEKKSKYPILPLWL 258
Cdd:PRK14995 180 RYVPRQ-AGRRDQPLNLGHALMLIVAILLLVYSAktaLKGFLSLW---VTSLTLLTGALLLGLFIRTQLAASRPMIDMRL 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 259 FNNRQFSVGnlllfiVGMGMMNIIFLLSF--FLTQ----VQGISELKAGLIIsvlaIFSMIVTTIMTPIA----TKKGSR 328
Cdd:PRK14995 256 FTHRIILSG------VVMAMTAMITLVGFelLMAQelqfVHGLSPLEAGMFM----LPVMVASGFSGPIAgilvSRLGLR 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 329 WIGMAGMLLLAVTTYSFTTmsTDFTS---LDYIWRVAVGGVGTGCTLApiSTTAILS-VPVNKSGMASSITNISRTIGSI 404
Cdd:PRK14995 326 LVATGGMALSALSFYGLAM--TDFSTqqwQAWGLMALLGFSAASALLA--STSAIMAaAPPEKAAAAGAIETMAYELGAG 401

                        410
                 ....*....|
gi 507051323 405 LGVAVLVALL 414
Cdd:PRK14995 402 LGIAIFGLLL 411
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
10-409 5.16e-30

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 121.53  E-value: 5.16e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSL 89
Cdd:COG2223    6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  90 LCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFIN 169
Cdd:COG2223   86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 170 IPIGLIACVLVLILFKESYDELSEKKidwlgvllssLFLFTLVLALLKvnddswnkeyiillfvisiisfisfiniekks 249
Cdd:COG2223  166 GILLLVVAVLAWLFLRDPPAGAAAAA----------KASLRDQLEALR-------------------------------- 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 250 kypilplwlfnNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRW 329
Cdd:COG2223  204 -----------DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 330 IGMAGMLLLAVTTYSFTTMSTDFTSldYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNisrTIGSILGVAV 409
Cdd:COG2223  273 VLLIVFALMALGLLLLALALGSLWL--FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVG---AAGGLGGFLG 347
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 12-426 7.12e-29

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 117.75  E-value: 7.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  12 FALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLC 91
Cdd:cd17476    1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  92 GLSISLETIVLFRVIQGISAAIIVPVAMP-LGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINI 170
Cdd:cd17476   81 GFSPNFIFFIICRALQGLGPAFLLPNAMAlLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 171 piglIACVLVLILFkesydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekksk 250
Cdd:cd17476  161 ----ILAAIVAVAA------------------------------------------------------------------ 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 251 ypilplWLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWI 330
Cdd:cd17476  171 ------IFWTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYI 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 331 GMAGMLLLAVTTYSFTTMSTDFTSLDYI-WRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAV 409
Cdd:cd17476  245 MAISMVAFLVGPILFATMPVHQTYWAQAfPAMIVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGI 324

                        410
                 ....*....|....*..
gi 507051323 410 LVALLNNQLESQLNLVK 426
Cdd:cd17476  325 AGTVETSVNEDGADLLK 341
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 11-406 3.12e-27

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 113.03  E-value: 3.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLL 90
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  91 CGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMgaFGGLAAAI--GPALGGILSDQLSWKWIFFI 168
Cdd:cd17324   81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLV--FSGLTLGLvlGRPLGGLLGQLLGWRAAFLA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 169 nipIGLIACVLVLILFKesydelsekkidwlgvllsslflftlvlaLLKVNDDSwnkeyiillfvisiisfisfiniEKK 248
Cdd:cd17324  159 ---IAVLALLAALLLWR-----------------------------LLPSLPPK-----------------------KPG 183

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 249 SKYPILPLW-LFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGS 327
Cdd:cd17324  184 SLGLLSSLLlLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGR 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 328 RWIgMAGMLLLAVTTYSFTTMSTdftsldYIWRVAVG----GVGTGCTLAPISTTAILSVPVNK---SGMASSITNISRT 400
Cdd:cd17324  264 RAL-LIALLLLAAALLLLTLLGP------SPLLLLVGlvlwGLGFFAAHSALQTRVLRLAPEARglaSSLYLAAYNLGGA 336


                 ....*.
gi 507051323 401 IGSILG 406
Cdd:cd17324  337 LGAALG 342
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 32-415 1.40e-26

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 111.51  E-value: 1.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  32 LPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISA 111
Cdd:cd17320   22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 112 AIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKESYDEL 191
Cdd:cd17320  102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEE 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 192 SEKKIDWlgvllsslflftlvlALLKVnddswnkeYIILLFvisiisfisfiniekkskypilplwlfnNRQFsVGNLLL 271
Cdd:cd17320  182 KRKPLLS---------------SLLRA--------YKRVLK----------------------------NRRF-LGYALA 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 272 FIVGMGMMNI-IFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYSF--TTM 348
Cdd:cd17320  210 LGLSFAGLFAyLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLllAAL 289

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507051323 349 STDFTSLDYIWRVAVGGVGTGCTLaPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALLN 415
Cdd:cd17320  290 LGGLSLWPLVAPLFLIFFGFGLIF-PNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN 355
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 9-410 7.04e-25

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 106.14  E-value: 7.04e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISGFFMAIldsnivnIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:cd17489    3 LANFFFFLSFYLLL-------PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALAT 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  89 LLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFI 168
Cdd:cd17489   76 LLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 169 NIPIGLIACVLVLILfkesYDELSEKKidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniEKK 248
Cdd:cd17489  156 AAVLALLALLLVFLV----KDPPPVAA--------------------------------------------------EEA 181

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 249 SKYPILPLWLFNNRQFSVGNLLLFIvGMGMMNIIFLLSFFLTQvQGISelKAGLIISVLAIFSMIVTTIMTPIATKKGSR 328
Cdd:cd17489  182 EAGTRAFRRLVEKKVLPPALILFLA-SIAYGAISTFLPLYAAE-RGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPK 257

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 329 WIGMAGMLLLAVTTYSFTTMstdftslDYIWRVAVGGVGTGC---TLAPISTTAILS-VPVNKSGMASSITNISRTIGSI 404
Cdd:cd17489  258 TVIIPGLLLLALGLLLLSFA-------GSPWMLLLAAVLYGLgfgLLFPALQALAVDlVPPHRRGAANGTFFIFFDLGIG 330


                 ....*.
gi 507051323 405 LGVAVL 410
Cdd:cd17489  331 LGGLLL 336
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 11-415 1.08e-24

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 105.73  E-value: 1.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIVLPEMTISFNTSVEH-ISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSL 89
Cdd:cd17473    1 LITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELlVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  90 LCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDqLSWKWIFFIN 169
Cdd:cd17473   81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 170 IpIGLIACVLVLILFKESYDELSEKKIdwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfINIEKKS 249
Cdd:cd17473  160 L-LALPVLILVLLFLPEPARKSKSAAS----------------------------------------------PGAATAA 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 250 KYPILPLWLFnnrqfsvgNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRW 329
Cdd:cd17473  193 ALPWKRVLPI--------YFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 330 IGMAGMLLLAVttySFTTMStdfTSLDYIWRVA---VGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:cd17473  265 LLAIGFALMAL---GFLLLA---LASGLWVVLLgaiLAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLS 338


                 ....*....
gi 507051323 407 VAVLVALLN 415
Cdd:cd17473  339 PLVLGPLVN 347
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 11-416 1.60e-21

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 96.13  E-value: 1.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIVLPEM--TISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLaaEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  89 LLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGG----LAAAIGPALGGILSDQLSWKW 164
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSGDWGWRI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 165 IFFinipIGLIACVLVLILFKesydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfin 244
Cdd:cd17316  161 LFL----IGALPALLALLLRR----------------------------------------------------------- 177

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 245 iekkskyPILPLWLFNnrqfsvgnlllFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATK 324
Cdd:cd17316  178 -------RTLLLILLW-----------FFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 325 KGSRWIGMAGMLLLAVTTY-SFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSiTNISRTIGS 403
Cdd:cd17316  240 IGRKKTLVIGLILSGILALpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLS-YNLGRLGGG 318

                        410
                 ....*....|...
gi 507051323 404 ILGVAVLVALLNN 416
Cdd:cd17316  319 GAPPLIALLLAST 331
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 9-184 2.55e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 95.72  E-value: 2.55e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISGFFMAIldsNIVNIVLP-EMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTIS 87
Cdd:cd17325  202 LALFLAIFVLAFAF---GALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVA 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  88 SLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFF 167
Cdd:cd17325  279 LLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358

                        170
                 ....*....|....*..
gi 507051323 168 INIPIGLIACVLVLILF 184
Cdd:cd17325  359 AAAALLLLAAVLFLLLR 375
2_A_01_02 TIGR00880
Multidrug resistance protein;
47-187 3.16e-21

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 90.02  E-value: 3.16e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   47 SWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELV 126
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323  127 PKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKES 187
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-410 1.92e-20

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 93.38  E-value: 1.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   1 MNNKlTHSFALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIG 80
Cdd:COG0738    1 MSKK-NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  81 LFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIgGIMGAFGGLAAAIGPALGGIL---S 157
Cdd:COG0738   80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLillG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 158 DQLSWKWIFFInipIGLIACVLVLILFKESYDELSEKKidwlgvllsslflftlvlallkvnddswnkeyiillfvisii 237
Cdd:COG0738  159 LSLSWHLPYLI---LAVLLLLLALLFLRSKLPEIEEEE------------------------------------------ 193

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 238 sfisfiniEKKSKYPILPLWLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTI 317
Cdd:COG0738  194 --------EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFL 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 318 MTPIATKKGSRWIGMAGMLLLAVTTYSFTTMSTDFTSLdyiWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSItni 397
Cdd:COG0738  266 GGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLAL---IGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAV--- 339

                        410
                 ....*....|...
gi 507051323 398 srTIGSILGVAVL 410
Cdd:COG0738  340 --LIMGIVGGAIG 350
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 9-184 5.34e-19

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 88.79  E-value: 5.34e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISgfFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:cd17323    1 VFIISFLT--FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQ 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  89 LLCGLSISLETIVLFRVIQGI-SAAIIVPVAMPLGlELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFF 167
Cdd:cd17323   79 IGCALAPNIAMLIILRFLQGFfGSSPLAIGAGTIA-DLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFW 157

                        170
                 ....*....|....*..
gi 507051323 168 INIPIGliACVLVLILF 184
Cdd:cd17323  158 FLAIIS--GFCLILIFL 172
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 17-414 4.64e-18

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 85.70  E-value: 4.64e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  17 GFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSIS 96
Cdd:cd17319   11 AYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATS 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  97 LETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFInipIGLIA 176
Cdd:cd17319   91 LTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII---EGLLG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 177 CVLVLilfkesydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekkskypilpL 256
Cdd:cd17319  168 LLLAV--------------------------------------------------------------------------L 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 257 WLFNNRQFsvgnLLLFIVGMGMMNIIFLLSF----FLTQVQGISELKAGLIIS---VLAIFSMIVTTIMTPIATKKGSRW 329
Cdd:cd17319  174 WWFYLRQV----WGLALGYFGINYALYGLLTwlptYLKQARGFSLKQVGLLAAipfLAGAIGMILGGRLSDRLLRGARRL 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 330 IGMAGMLLLAVTTYSFTTMSTDFTSLdyIWrVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAV 409
Cdd:cd17319  250 VIIIGLLLAAVGLLLAYLTTSPVVAV--IL-LSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLL 326


                 ....*
gi 507051323 410 LVALL 414
Cdd:cd17319  327 IGYLV 331
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 8-187 1.79e-17

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 84.36  E-value: 1.79e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323    8 SFALFALISGFFM-AILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTI 86
Cdd:TIGR00710   3 AKAFALLLGCLSIlGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   87 SSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIF 166
Cdd:TIGR00710  83 SSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIF 162

                         170       180
                  ....*....|....*....|.
gi 507051323  167 FINIPIGLIACVLVLILFKES 187
Cdd:TIGR00710 163 AFLSLAGILLSALIFFILPET 183
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 53-187 3.29e-16

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 80.34  E-value: 3.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  53 YNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAaiIVPVAMPLGLELVPKEKQG 132
Cdd:cd17472   41 YGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALLADLTREENRT 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 507051323 133 IIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKES 187
Cdd:cd17472  119 KAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDP 173
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
42-188 4.46e-16

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 79.91  E-value: 4.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  42 SVEHISWVINSYNLAFAVCLLPMAKLADRFGR--KKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAM 119
Cdd:COG2271  214 SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW 293

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507051323 120 PLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKESY 188
Cdd:COG2271  294 ALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 23-186 6.93e-15

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 76.51  E-value: 6.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  23 LDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVL 102
Cdd:cd17328   13 MDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 103 FRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQ-LSWKWIFFINIPIGLIACVLVL 181
Cdd:cd17328   93 FRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLL 172


                 ....*
gi 507051323 182 ILFKE 186
Cdd:cd17328  173 LFVRE 177
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 4-287 2.42e-14

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 75.86  E-value: 2.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323    4 KLTHSFALFAL--ISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSynlafAVCLLPMAKLADRFGRKKFYVIGL 81
Cdd:pfam06609  41 RIIASFAAFSLnvCATYFVLQASASALPNILQDIGQSENQGLFSTLWTMGQ-----AVSILMMGRLTDRFGRRPFVIATH 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   82 FVFTISSLLCGLSISLETIVLFRVIQGISAAiivPV-AMPLGLELVPKEKQGIIGGIMGAFGGLA-AAIGPALGGILSDQ 159
Cdd:pfam06609 116 IIGLVGAIVGCTANKFNTLLAAMTLLGVAAG---PAgASPLFIGELMSNKTKFLGLLIVSAPTIAmNGAGPYFGQRLAIQ 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  160 LSWKWIFFINIPIGLIACVLVLILF-KESYDELSEK---------KIDWLGVLLSSLFLFtlvLALLKVN-----DDSWN 224
Cdd:pfam06609 193 GNWRWIFYIYIIMSAIAVLLIIIWYhPPSFAQLHGKkarkrdelaKLDWIGIFLVIAGTS---LFLLGVSwggkpNNPWN 269

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507051323  225 KEYIILLFVISIISFISFINIE--KKSKYPILPLWLFNNRQFSVGNLLLFIVgMGMMNIIFLLSF 287
Cdd:pfam06609 270 SAKIIGLISSGAGSLVIFALYEvfGKPEQPIIPPALFKDTRGFVCILIISSI-MGAMHLCLTIIY 333
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 1-197 1.22e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 72.77  E-value: 1.22e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323    1 MNNKLTHSFALFALISgfFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIG 80
Cdd:TIGR00895  11 LSRYQWRAIILSFLIM--LMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   81 LFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQL 160
Cdd:TIGR00895  89 ILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF 168

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 507051323  161 SWKWIFFINIPIGLIACVLVLILFKESYDELSEKKID 197
Cdd:TIGR00895 169 GWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPE 205
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
55-394 2.12e-13

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 72.21  E-value: 2.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  55 LAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKeKQGII 134
Cdd:COG2807   64 LAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLM 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 135 GGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKESydelsekkidwlgvllsslflftlvla 214
Cdd:COG2807  143 TGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR--------------------------- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 215 llkvnddswnkeyiillfvisiisfisfINIEKKSKYPILPLWLFNNRQFsvgnlLLFIVGMGMMNIIFLLSF-----FL 289
Cdd:COG2807  196 ----------------------------PAAAAAAPAAASLRSLWRSPLA-----WLLTLFFGLQSLLYYAVVawlppIL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 290 TQvQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTtySFTTMSTDFTSLDYIWrVAVGGVGTG 369
Cdd:COG2807  243 RD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLA--GLLGLLLAPGSLPWLW-AVLLGLGQG 318

                        330       340       350
                 ....*....|....*....|....*....|
gi 507051323 370 CTLAPISTTAILSVPVNK-----SGMASSI 394
Cdd:COG2807  319 GLFPLALTLIGLRARTPAeaaalSGMAQSV 348
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 14-184 2.18e-13

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 71.46  E-value: 2.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  14 LISGFFMAILDS---NIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLL 90
Cdd:cd17365    1 LALCFLIIVLDGfdlAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  91 CGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFini 170
Cdd:cd17365   81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL--- 157

                        170
                 ....*....|....
gi 507051323 171 pIGLIACVLVLILF 184
Cdd:cd17365  158 -LGGVPPLILLPLL 170
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 24-183 2.47e-13

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 71.83  E-value: 2.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  24 DSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLF 103
Cdd:cd17359   16 DTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 104 RVIQGI---SAAIIVPVAMPlglELVPKEKQG---------IIGGIMGAFgGLAAAIGPALGGILSDQLSWKWIFFINIP 171
Cdd:cd17359   96 RIIGGLavgGASALVPMYIA---EVAPAEIRGrlvslnqlmIVFGQLLAY-IVNYLIANAGGADWLGAEGWRWMLGLEAI 171

                        170
                 ....*....|..
gi 507051323 172 IGLIACVLVLIL 183
Cdd:cd17359  172 PAILFLLGMLFI 183
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
32-187 3.53e-13

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 71.10  E-value: 3.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  32 LPEM-TIS--FNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQG 108
Cdd:PRK11102  11 LPALpVIAadFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 109 ISAAIIVPVAMPLGLELVPKEK----QGIIGGIMgafgGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILF 184
Cdd:PRK11102  91 LAAAAASVVINALMRDMFPKEEfsrmMSFVTLVM----TIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFI 166


                 ...
gi 507051323 185 KES 187
Cdd:PRK11102 167 PET 169
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 31-409 4.96e-13

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 70.30  E-value: 4.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  31 VLPEMTISFNT---SVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQ 107
Cdd:cd17330   18 VLPFYVREFNKlgaSGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLD 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 108 GISAAIIVPVAMPLGlELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLilfkes 187
Cdd:cd17330   98 GLTGGNVSVAQAYIA-DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVL------ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 188 ydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekkskypilpLWLFNNRQFSVG 267
Cdd:cd17330  171 --------------------------------------------------------------------FFLPPLRRLLLV 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 268 NLLLFIVGMGMMNIiflLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYSFTT 347
Cdd:cd17330  183 YFLIALAFAGLESV---FSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLP 259

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507051323 348 MSTDFTSLdyIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAV 409
Cdd:cd17330  260 FASSVPLL--VLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLL 319
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 10-181 2.83e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 68.61  E-value: 2.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADR-FGRKKFYVIGLFVFTISS 88
Cdd:cd06174  205 LWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  89 LLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQ-LSWKWIFF 167
Cdd:cd06174  285 ALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFL 364

                        170
                 ....*....|....
gi 507051323 168 INIPIGLIACVLVL 181
Cdd:cd06174  365 VLAVLLLLAAILLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
5-148 3.89e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.69  E-value: 3.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   5 LTHSFALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVF 84
Cdd:COG2814  204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507051323  85 TISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAI 148
Cdd:COG2814  284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 11-183 4.81e-12

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 67.71  E-value: 4.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIVLPEMTISFNtsvehisWVINSYNLAFAVCLLPMA-------KLADRFGRKKFYVIGLFV 83
Cdd:cd17371    1 FWAAFLGWALDGFDLLLLGLVLPALIAEFG-------LDEAEAGLLGTVTLAGGAiggilggILADRFGRVRVLVITILL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  84 FTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAF----GGLAAAIGPALGGILSDQ 159
Cdd:cd17371   74 FAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGwavgWLLATLLAALLFPLLPPE 153

                        170       180
                 ....*....|....*....|....
gi 507051323 160 LSWKWIFFinipIGLIACVLVLIL 183
Cdd:cd17371  154 IAWRVLFL----LGALPALLVLFI 173
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 17-413 5.39e-12

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 67.75  E-value: 5.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   17 GFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSIS 96
Cdd:TIGR00893   2 VTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   97 LETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFInipIGLIA 176
Cdd:TIGR00893  82 YVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFII---EGVLG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  177 CVLVLILFKESYDELSEKKIdwlgvllsslflftlvlalLKVNDDSWnkeyiillfvisiisFISFINIEKKSKYPILPL 256
Cdd:TIGR00893 159 IIWGVLWLKFIPDPPQKAKW-------------------LTEEEKYI---------------VVGGLLAEQQGKGPSTPK 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  257 W-----LFNNRQFsvgnLLLFIvGMGMMNII--FLLSFF---LTQVQGISELKAGLIISVLAIF---SMIVTTIMTPIAT 323
Cdd:TIGR00893 205 KyqikeLLKDRRV----WGLAL-GQFLVNIGlgFFLTWFptyLVQERGLSILEAGFMASLPGIVgfiGMILGGRLSDLLL 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  324 KKG-----SRWIGMAGMLLLAVTTYSFTTMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAilsvPVNKSGMASSITNIS 398
Cdd:TIGR00893 280 RRGkslvfARKTAIIAGLVLSLLMFATNYVNIPYAALALVALGFFGLGAGAIGWALISDNA----PGNIAGLTGGLINSL 355

                         410
                  ....*....|....*
gi 507051323  399 RTIGSILGVAVLVAL 413
Cdd:TIGR00893 356 GNLGGIVGPIVIGAI 370
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 9-183 5.86e-12

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 67.21  E-value: 5.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISGFFMAILDSNIVniVLPE-MTISFNTSVEHISWVINSYNLAFAVCLLPMAK-LADRFGRKKFYVIGLFVFTI 86
Cdd:cd17474  200 LLTFLVSAFLYFFLYFAFLT--YLPFlLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARRILVIGLLLYAL 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  87 SSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIF 166
Cdd:cd17474  278 SLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF 357

                        170
                 ....*....|....*..
gi 507051323 167 FINIPIGLIACVLVLIL 183
Cdd:cd17474  358 LVGAAIALAAAVLLALL 374
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 17-410 7.23e-12

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 67.02  E-value: 7.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   17 GFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSIS 96
Cdd:TIGR00881   3 GYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   97 LETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQL-SWKWIFFINipiGLI 175
Cdd:TIGR00881  83 LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVP---GII 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  176 ACVLVLILFKESYDELSEKKIDwlgvllsslflftlvlallkvNDDSWNKEYiillfvisiISFISFINIEKKSKYPILP 255
Cdd:TIGR00881 160 AIIVSLICFLLLRDSPQSCGLP---------------------PAEEMPNEE---------PDGDAEKKEEELTKKQIFL 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  256 LWLFNNRQ---FSVGNLLLFIVGMGMMNiifLLSFFLTQVQGISELKAGLIISVL---AIFSMIVTTIMTPIATKKGSRW 329
Cdd:TIGR00881 210 QYVLLNKVlwyISLGYVFVYVVRTGILD---WSPLYLTQEKGFSKEKASWAFTLYelgGLVGTLLAGWLSDKLFNGRRGP 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  330 IGMAGMLLLAVTTYSFTTMSTDFTSLDYIWRVAVGGVGTGcTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAV 409
Cdd:TIGR00881 287 LAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYG-PQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLP 365


                  .
gi 507051323  410 L 410
Cdd:TIGR00881 366 L 366
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 7-184 1.27e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 66.48  E-value: 1.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   7 HSFALFALISGFFMAILDSNIVNIVLpEMTISFNTSVEHISWVInSYNLAFAVCL-LPMAKLADRFGRKKFYVIGLFVFT 85
Cdd:cd17329  200 RAFLLFLLASFLISLIYFQLESTLPV-YVVEILGLGESLLGLLL-ALNALLIVLLqFPVARLVERFRLRKILMIGILLFA 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  86 ISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWI 165
Cdd:cd17329  278 IGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLP 357

                        170
                 ....*....|....*....
gi 507051323 166 FFINIPIGLIACVLVLILF 184
Cdd:cd17329  358 WLILAALGLIAAALLLGLQ 376
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 66-183 2.06e-11

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 66.19  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   66 KLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLA 145
Cdd:TIGR00898 149 YLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLG 228

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 507051323  146 AAIGPALGGILSDqlsWKWIFF-INIPiGLIACVLVLIL 183
Cdd:TIGR00898 229 LVLLPLVAYFIPD---WRWLQLaVSLP-TFLFFLLSWFV 263
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 16-196 2.60e-11

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 65.42  E-value: 2.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  16 SGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSI 95
Cdd:cd17333    3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  96 SLETIVLFRVIQGISAAIIVPVAMPLGLELVPkEKQGIIGGIMGAFGGLAAAIGPALGG-ILSDQLSWKWIFFInipIGL 174
Cdd:cd17333   83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLI---IGL 158

                        170       180
                 ....*....|....*....|..
gi 507051323 175 IACVLVLILFKESYDELSEKKI 196
Cdd:cd17333  159 IYLLLAILILLTLFPELPSARN 180
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 53-181 3.08e-11

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 65.26  E-value: 3.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  53 YNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQG 132
Cdd:cd17370  243 FNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 507051323 133 IIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVL 181
Cdd:cd17370  323 TAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
9-184 3.29e-11

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 65.31  E-value: 3.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISGFFMAILDSnivnIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:COG2211  233 LLLAYLLFFLALALVAA----LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  89 LLCGLSI--SLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQ-------GIIGGIMGAFGGLAAAIGPALGGILSDQ 159
Cdd:COG2211  309 LLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLAL 388

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 507051323 160 -------------LSWKWIFFINIPIGLIACVLVLILF 184
Cdd:COG2211  389 fgyvagaaqspsaLTGIRLLFFLLPAVLLLLAALLLLF 426
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
35-184 5.79e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 64.49  E-value: 5.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  35 MTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAII 114
Cdd:COG0738  237 LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLM 316

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 115 VPVAMPLGLELVPKEKQGIIGGIMgAFGGLAAAIGPALGGILSDQLSWKWIFFInipigLIACVLVLILF 184
Cdd:COG0738  317 FPTIFSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLADAFGLRAAFLV-----PLVCYLLILLL 380
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
8-414 1.31e-10

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 63.77  E-value: 1.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   8 SFALFALISGFFMAILDSNIVNIvlpeMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLAD----RFGRKKFYV-IGLF 82
Cdd:COG2211   14 AYGLGDLGLNLAFGLLSAYLLYF----YTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWIlIGAI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  83 VFTISSLLCGLSISLETIVLF------RVIQGISAAIIVPVAMPLGLELVPKEKQ-GIIGGIMGAFGGLAAAIGPALGGI 155
Cdd:COG2211   90 PLALSFVLLFTAPDLSPTGKLiyalvtYLLLGLAYTLVNIPYSALGAELTPDYEErTRLSSWRFAFAGLGGLLASVLPPP 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 156 L------SDQLSWKWIFFInipIGLIACVLVLILFKesydelsekkidwlgvllsslflftlvlallkvnddsWNKEYII 229
Cdd:COG2211  170 LvaafggDAALGYRLTALI---FAVLGLLAFLLTFF-------------------------------------GTKERPV 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 230 llfvisiisfisfiniEKKSKYPILPLW--LFNNRQFS--VGNLLLFIVGMGMMNIIFLlsFFLTQVQGISELKAGLIIS 305
Cdd:COG2211  210 ----------------PEEEKVSLKESLkaLLKNRPFLllLLAYLLFFLALALVAALLL--YYFKYVLGLSAALVGLLLA 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 306 VLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYSFTtmstdFTSLDYIWRVAVGGVGTGCTLAPISTT--AILS- 382
Cdd:COG2211  272 LYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF-----FLGPGNLWLLLVLAALAGIGLGAILVLpwAMLAd 346

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 507051323 383 -VP-------VNKSGMASSITNISRTIGSILGVAVLVALL 414
Cdd:COG2211  347 vVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLL 386
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 11-187 1.56e-10

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 63.06  E-value: 1.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFfmailDSNIVNIVLPEMTISFNTSVEHISWVINsynlAFAVCLLPMA----KLADRFGRKKFYVIGLFVFTI 86
Cdd:PRK11551  22 LVALLEGL-----DLQSAGVAAPRMAQEFGLDVAQMGWAFS----AGILGLLPGAllggRLADRIGRKRILIVSVALFGL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  87 SSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGA---FGG-LAAAIGPALGGilsdQLSW 162
Cdd:PRK11551  93 FSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCgvpFGGaLASVIGVLAAG----DAAW 168

                        170       180
                 ....*....|....*....|....*.
gi 507051323 163 KWIFFINiPIGLIACVLVLILF-KES 187
Cdd:PRK11551 169 RHIFYVG-GVGPLLLVPLLMRWlPES 193
Sugar_tr pfam00083
Sugar (and other) transporter;
12-183 2.05e-10

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 63.06  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   12 FALISGFfmAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLC 91
Cdd:pfam00083  16 TGVIGAF--LTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQ 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   92 GLSI---SLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGI---MGAFGGLAAAIGPALGGILSDQLSWKWI 165
Cdd:pfam00083  94 GAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLyqlAITFGILLAYIFGLGLNKTSNSDGWRIP 173

                         170
                  ....*....|....*...
gi 507051323  166 FFINIPIGLIACVLVLIL 183
Cdd:pfam00083 174 LGLQLVPALLLIIGLLFL 191
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 45-184 2.93e-10

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 61.83  E-value: 2.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  45 HISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLE 124
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 125 LVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDqlsWKWIFFInipIGLIACVLVLILF 184
Cdd:cd17317  106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLA---ISLPGLLFLLLLW 159
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 11-414 5.68e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 61.48  E-value: 5.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVI-----GLFVFT 85
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  86 ISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWI 165
Cdd:cd06173   81 LALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 166 FFINIpIGLIACVLVLILFKESYDELSEKKIDWLGVLLSSLFlftlvlallkvnddswnkeyiillfvisiisfisfini 245
Cdd:cd06173  161 FAINA-LSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGL-------------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 246 ekkskypilpLWLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKK 325
Cdd:cd06173  202 ----------RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 326 GSRWIGMAGMLLLAVTTYSFTTMSTDFTSLdyIWrVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSIL 405
Cdd:cd06173  272 RRGRLLLIGALLLGLALLVLGLSPSLWLLL--AA-LFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348


                 ....*....
gi 507051323 406 GvAVLVALL 414
Cdd:cd06173  349 G-ALLAGLL 356
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 64-185 6.05e-10

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 61.09  E-value: 6.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  64 MAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGG 143
Cdd:cd06173  264 LGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS 343

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 507051323 144 LAAAIGPALGGILSDQLSWKWIFFInipIGLIACVLVLILFK 185
Cdd:cd06173  344 GAMPLGALLAGLLADALGLSAVFLL---AGALLLLAALLLLL 382
MFS_1 pfam07690
Major Facilitator Superfamily;
11-150 6.40e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.89  E-value: 6.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   11 LFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLL 90
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507051323   91 CGLSISLETIVLFR---VIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGP 150
Cdd:pfam07690 282 LLLLSLTLSSLWLLlalLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 44-184 7.28e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 60.69  E-value: 7.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  44 EHISWVINSYNLAFAVCLLPM----AKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAM 119
Cdd:cd17489  223 ERGISNAGLFFTVYAIALLLSrpfsGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQ 302

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507051323 120 PLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILF 184
Cdd:cd17489  303 ALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 55-195 8.70e-10

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 60.74  E-value: 8.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  55 LAFAVCLLPMA-------KLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIvPVAMPLGLELVP 127
Cdd:cd17391   40 LAFSSTFLVSAifspiwgRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQTP 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507051323 128 KEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKESYDELSEKK 195
Cdd:cd17391  119 KEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKK 186
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 25-413 1.19e-09

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 60.26  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  25 SNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFR 104
Cdd:cd17478   12 QGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 105 VIQGISAAIIVPVAMPLgLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILF 184
Cdd:cd17478   92 ALAGIGSAAFHPEGARL-ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 185 KESYDELSEKKidwlgvllsslflftlvlallkvnddswnkeyiillfvisiiSFISFINIEKKSKYPILPLWlfnnrqf 264
Cdd:cd17478  171 PLKKPEAKKAA------------------------------------------AKSSARSTLKGVWRALLLLL------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 265 svgnLLLFIVGMGMMNIIFLLSFFLTQvQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYS 344
Cdd:cd17478  202 ----IIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLL 276

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507051323 345 FTtmstdFTSLdyIWRVAVGGVGTGCTLAPISTTAILS---VPvNKSGMASSITN-ISRTIGSIlGVAVLVAL 413
Cdd:cd17478  277 FL-----LTPG--IWSYILLVLAGFLLFASFPVTVVLAqelLP-GNVGLASGLMMgLSFGLGGI-GAPVLGAL 340
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 14-420 1.25e-09

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 60.36  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  14 LISGFFMAILDSNIVN---IVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLL 90
Cdd:cd17355    5 LAVTFLILILSWGIRYyfgVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  91 CGLSISL-ETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIF-FI 168
Cdd:cd17355   85 LALATSLwQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALlVL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 169 NIPIGLIACVLVLILFKESYDELSEkkidwlgvllsslflfTLVLALLKVNDDSWNKeyiillfvisiisfisfiniekk 248
Cdd:cd17355  165 ALLALLVLVPVLLLLRRRPADLALR----------------AYDDASPASPGSTLKE----------------------- 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 249 skypilplwLFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQvQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSR 328
Cdd:cd17355  206 ---------ALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPR 275

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 329 WIGMAGMLLLAVTTYSFttMSTDFTSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGvA 408
Cdd:cd17355  276 RLLAASYALRALGLALL--LLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALG-P 352

                        410
                 ....*....|..
gi 507051323 409 VLVALLNNQLES 420
Cdd:cd17355  353 WLGGLLYDRTGS 364
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 67-187 1.74e-09

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 59.97  E-value: 1.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLF---RVIQGISAAIIVpVAMPLGL-ELVPKEKQGIIG---GIMG 139
Cdd:cd17357   72 LANRFGRKNGLLISNALLVVSSLLMFLSKSAKSPELLifgRFLVGIACGLST-GFVPMYLqEISPSELRGALGsltQIGV 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 507051323 140 AFGGLAAAIgPALGGILSDQLSWKWIFFINIPIGLIaCVLVLILFKES 187
Cdd:cd17357  151 TLGILLGQV-FGLPSVLGTETLWPYLLFFPGIPALL-QLAALPFFPES 196
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 38-183 1.99e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 59.51  E-value: 1.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  38 SFNTSVEHISWVINSYNLAFAVCLLPMAKLADRF---GRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAII 114
Cdd:cd17319  209 ARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrgARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAA 288

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 115 VPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQL-SWKWIFFINIPIGLIACVLVLIL 183
Cdd:cd17319  289 SPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATgSYTAAFLFLAAVALLAALLVLLL 358
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
10-183 2.01e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 59.50  E-value: 2.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFALISGFFMAildsniVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSL 89
Cdd:COG2807  222 LFFGLQSLLYYA------VVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGL 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  90 LCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQ-GIIGGIMGAFGGLAAAIGPALGGILSDQL-SWKWIFF 167
Cdd:COG2807  296 LGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATgSWTAALL 375

                        170
                 ....*....|....*.
gi 507051323 168 INIPIGLIACVLVLIL 183
Cdd:COG2807  376 LLAALAVLMLVAGLLA 391
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
269-416 3.12e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 58.73  E-value: 3.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 269 LLLFIVGMGMMNIIFLLSFFLTQVQ---GISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYsF 345
Cdd:COG2271   13 ALLFLAYFLNYLDRSNLSVAAPPLQadlGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL-L 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323 346 TTMSTDFTSLdYIWRVAVGgVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALLNN 416
Cdd:COG2271   92 FGFATSFWQL-LLLRFLLG-LGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
MFS_1 pfam07690
Major Facilitator Superfamily;
269-414 3.18e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 58.58  E-value: 3.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  269 LLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYSFTTM 348
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507051323  349 STDFTSLdyIWRVaVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALL 414
Cdd:pfam07690  83 SSLWLLL--VLRV-LQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA 145
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 11-183 4.81e-09

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 58.42  E-value: 4.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLL 90
Cdd:cd17341    1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  91 CGLSI-SLETIVLFRVIQGISAAIIVpVAMPLGLELVPKEKQG----IIGGIMGAFGGLAAAIGPALGGILSDQLS---W 162
Cdd:cd17341   81 LALAVsSYWGLLVLGFLLGFAGANFA-SGQPWASFWFPKEKIGgaagGIAGAGNMGVAVSQLLAPLIAGAIVFDGGfvgW 159

                        170       180
                 ....*....|....*....|.
gi 507051323 163 KWIFFINIPIGLIACVLVLIL 183
Cdd:cd17341  160 RNAFFVPGILLAIAAVLVLLF 180
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 10-406 1.19e-08

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 57.18  E-value: 1.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFALISGFFMAILDSNIVNIVLPEMTISFNTSvehiswvinSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSL 89
Cdd:cd17477    6 ALLGLGSGLLLPLLSLRLEREGVSTALIGLVAS---------AYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  90 LCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILsDQLSWKWiFFIN 169
Cdd:cd17477   77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV-GTAGALP-FLIA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 170 IPIGLIACVLVLILFKESYDELSEKKIDWLGVllsslflftlvlallkvnddswnkeyiillfvisiisfisfiniekks 249
Cdd:cd17477  155 AVLLLLALVPLLLTRRAAPEIEEAESISLRRL------------------------------------------------ 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 250 kYPILPLwlfnnrqfsvGNLLLFIVGMGMMNIIFLLSFFLTQVqGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRW 329
Cdd:cd17477  187 -LRIAPL----------ALLGAFVAGFLEGAFYSLLPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRR 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 330 IGMAGMLLLAVTtySFTTMSTDFTSldyiWRVAVGGVGTGCTLAPISTTAIL----SVPVNKSGMASSITNISRTIGSIL 405
Cdd:cd17477  255 VLLGCALLGALA--ALLLPLVPGLP----LALLVLLFLWGGAAGPLYTLALAlagdRLPGDELVAANAALLLLYGLGSVI 328


                 .
gi 507051323 406 G 406
Cdd:cd17477  329 G 329
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
269-415 1.46e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.52  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 269 LLLFIVGMGMMNIIFLLSFfLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTySFTTM 348
Cdd:COG2814   17 LGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGS-LLCAL 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507051323 349 STDFTSLdYIWRVaVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALLN 415
Cdd:COG2814   95 APSLWLL-LAARF-LQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
PRK03545 PRK03545
putative arabinose transporter; Provisional
 32-185 1.57e-08

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 56.82  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  32 LPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISA 111
Cdd:PRK03545  32 LSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAH 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507051323 112 AIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFInipIGLIACVLVLILFK 185
Cdd:PRK03545 112 AIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLA---IGGGALITLLLLIK 182
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 29-185 1.57e-08

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 56.51  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  29 NIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQG 108
Cdd:cd17312   23 SVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNG 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 109 ISAAIIVPvamPLGLELVP---KEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINipiGLIACVLVLILFK 185
Cdd:cd17312  103 LFQSMGWP---PCVKLLGNwfsKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVP---GIVGLVVAIILFF 176
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 11-181 2.21e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 56.40  E-value: 2.21e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLL 90
Cdd:cd17324  201 RLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLL 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  91 CGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPkEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINI 170
Cdd:cd17324  281 TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGA 359

                        170
                 ....*....|.
gi 507051323 171 PIGLIACVLVL 181
Cdd:cd17324  360 ALLLLALLLAL 370
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 10-184 2.25e-08

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 56.04  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFALISGFFMAILdSNIVNIVLPEMTISFNTSVEhiSWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSL 89
Cdd:cd17315    3 ALGGLLFGYDLGVI-NGALLYIAKDLGFGLSTSLQ--GLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGAL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  90 LCGLSISLETIVLFRVIQGISAAIIVPVAmPLGL-ELVPKEKQGIIGGI---MGAFGGLAAAIgpaLGGILSDQLSWKWI 165
Cdd:cd17315   80 LSALAPNVWVLIVGRFLLGLGVGLASVLV-PLYIsEIAPAKIRGALGTLnqlMITFGILLAYL---LGLALSLSPPGWWR 155

                        170
                 ....*....|....*....
gi 507051323 166 FFINIPIGLIACVLVLILF 184
Cdd:cd17315  156 LMFALAAVPALLQLLLMFF 174
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
31-166 2.47e-08

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 56.10  E-value: 2.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  31 VLPEM---TISFNTSVEHISWVINSYnLAFAVCL-LPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVI 106
Cdd:PRK15402  32 IQPGMlavVEDFNAGAEWVPTSMTAY-LAGGMFLqWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFL 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323 107 QGISAAIIVPVAMPlGLELVPKEKQGI-IGGIMGAFGGLAAAIGPALGGILSDQLSWKWIF 166
Cdd:PRK15402 111 QGIGLCFIGAVGYA-AIQESFEEADAIkITALMANVALLAPLLGPLVGAALIHVLPWRGMF 170
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 14-410 2.72e-08

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 56.08  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  14 LISGFFMAILDSnivnIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMA----KLADRFGRKKFYVIGLFVFTISSL 89
Cdd:cd17329    5 LIGSFLNRLGFF----MVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASliggRLADRFGRKPVMLAGLLLRALGFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  90 LCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSdQLSWKWIFFIN 169
Cdd:cd17329   81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 170 IPIGLIACVLVLILFKESydelsekkidwlgvllsslflftlvlallkvnddswnkeyiillfvisIISFISFINIEKKS 249
Cdd:cd17329  160 AVLFLLAALVLLFLLPET------------------------------------------------RPKRRAAEKTEILR 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 250 KYPIlplwLFNNRQFsvgnLLLFIVGMGMMNIIFLLSF----FLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKK 325
Cdd:cd17329  192 GYKI----VLRDRAF----LLFLLASFLISLIYFQLEStlpvYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERF 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 326 GSRWIGMAGMLLLAVtTYSFTTMSTDFTSLdyIWRVAVGGVGTgCTLAPISTTAILS-VPVNK----SGMASSITNISRT 400
Cdd:cd17329  264 RLRKILMIGILLFAI-GFAVLAFANTLAVL--ILAMIVLTLGE-MLVFPAVQTLVAAlAPPDKrgsyMGFYALAWGLGRA 339

                        410
                 ....*....|
gi 507051323 401 IGSILGVAVL 410
Cdd:cd17329  340 IGPLVGGLLL 349
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 38-186 2.75e-08

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 56.08  E-value: 2.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  38 SFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFG-RKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVp 116
Cdd:cd17490   25 SLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWV- 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 117 VAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLvLILFKE 186
Cdd:cd17490  104 SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFIL-SLFIKE 172
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
67-196 5.54e-08

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 55.31  E-value: 5.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIvPVAMPLGLELVPKEKQGIIGGIMGAFGGLAA 146
Cdd:PRK09874  77 LADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFV-PNANALIATQVPRNKSGWALGTLSTGGVSGA 155

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 507051323 147 AIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKESYDELSEKKI 196
Cdd:PRK09874 156 LLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRENFQPVSKKEM 205
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 66-184 5.85e-08

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 54.92  E-value: 5.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  66 KLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLA 145
Cdd:cd17490  253 LFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALG 332

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 507051323 146 AAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILF 184
Cdd:cd17490  333 MFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
55-185 6.12e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.89  E-value: 6.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  55 LAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLcgLSISLETIVLFrviqgISAAIIVPVAMPLGL--------ELV 126
Cdd:COG2223  252 LLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL--LALALGSLWLF-----LVLFLLLGLALGGGNgavfalvpDIF 324

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 127 PKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQL-SWKWIFFINIPIGLIACVLVLILFK 185
Cdd:COG2223  325 PTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYR 384
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 6-183 7.08e-08

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 54.58  E-value: 7.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   6 THSFALFALisGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFT 85
Cdd:cd17355  209 SASFWLLAL--AFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRA 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  86 ISSLLCGLSISLETIVL-FRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQL-SWK 163
Cdd:cd17355  287 LGLALLLLLPFPPLALLlFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTgSYT 366

                        170       180
                 ....*....|....*....|
gi 507051323 164 WIFFINIPIGLIACVLVLIL 183
Cdd:cd17355  367 AAWALAVALGLIAALLVLPI 386
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
55-188 7.36e-08

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 54.64  E-value: 7.36e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  55 LAFAVCLLPMA-------KLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVP 127
Cdd:PRK10473  42 IAFSVYLAGMAaamlfagKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLD 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323 128 KEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKESY 188
Cdd:PRK10473 122 DRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGILVLLLSLFILKETR 182
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
35-181 7.43e-08

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 54.90  E-value: 7.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  35 MTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGI---SA 111
Cdd:PRK11043  32 IQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVgvcSA 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323 112 AIIvpvAMPLGLELVPKEK-QGIIGGIMgAFGGLAAAIGPALGGILSDQLSWKWIFFInipIGLIACVLVL 181
Cdd:PRK11043 112 AVI---WQALVIDRYPAQKaNRVFATIM-PLVALSPALAPLLGAWLLNHFGWQAIFAT---LFAITLLLIL 175
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 3-184 7.76e-08

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 54.58  E-value: 7.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   3 NKLTHSFALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISW----VINSYNLAFAVCLLPMAKLADRFGRKKFYV 78
Cdd:cd17391  195 NSVPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFisglVFSATGVSSLLSAPRLGKLGDRIGHHRILL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  79 IGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSD 158
Cdd:cd17391  275 GALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAA 354

                        170       180
                 ....*....|....*....|....*.
gi 507051323 159 QLSWKWIFFINIPIGLIACVLVLILF 184
Cdd:cd17391  355 HFGYRAVFVVTALLVLLNAIWSFIFL 380
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 31-187 8.39e-08

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 54.56  E-value: 8.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  31 VLPEMTISFNTSVE----HISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVI 106
Cdd:cd17388   21 VLPTLLREFVGDSAdaatHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRII 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 107 QGISAAiIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSdQLSWKWIFFINIPIGLIACVLVLILFKE 186
Cdd:cd17388  101 AGITGA-TGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLGLFVLPE 178


                 .
gi 507051323 187 S 187
Cdd:cd17388  179 S 179
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 35-182 1.68e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 53.37  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  35 MTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLE--TIVLFRVIQGISAA 112
Cdd:cd17316  204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSptLLLLLLFILSFFVG 283

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 113 IIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLI 182
Cdd:cd17316  284 GVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 67-406 1.80e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 53.32  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFG-RKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPV--AMpLGlELVPKEKQGIIGGIMGAFGG 143
Cdd:cd17370   57 LSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPrdAL-LA-DATPPSGRGKAFGLHRALDT 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 144 LAAAIGPALGGIL--SDQLSWKWIFFINIPIGLIAcVLVLILFKESYDELSEKKidwlgvllsslflftlvlallkvndd 221
Cdd:cd17370  135 LGAVLGPLLAALLlyLLGGNYRTIFLLAAIPALLA-LLILLFVVKEYPRPPKLR-------------------------- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 222 swnkeyiillfvisiisfISFINIEKKSKYPILPLWLFnnrqfsvgnlLLFIVGMGMMNIIFLLsfFLTQVQGISelkAG 301
Cdd:cd17370  188 ------------------KKSKKTSLKKLPKAFWLYLL----------AVALFALGNFSFAFLI--LRAQELGLS---AA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 302 LIISVLAIFsMIVTTIMTPIA----TKKGSRWIGMAGMLLLAVTTYSFttmsTDFTSLDYIW-RVAVGGVGTGCTLAPIS 376
Cdd:cd17370  235 LIPLLYALF-NLVYALAAYPAgrlsDRIGRKKLLILGYLSLALAYLGF----ALGSSLWLLLlGFILWGLYMGAQESIER 309

                        330       340       350
                 ....*....|....*....|....*....|
gi 507051323 377 TTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:cd17370  310 AAVADLVPAELRGTAYGLFNTVVGIGWLLA 339
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 9-184 2.10e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 53.35  E-value: 2.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISGFFMaildsniVNIVLPE-MTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTIS 87
Cdd:cd17473  204 FLAFLAMLLFYV-------IPIQLPFlLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  88 SLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFF 167
Cdd:cd17473  277 FLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAF 356

                        170
                 ....*....|....*..
gi 507051323 168 INIPIGLIACVLVLILF 184
Cdd:cd17473  357 LILGVLALVLAIVLLLL 373
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 13-183 2.91e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 52.56  E-value: 2.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  13 ALISGFFMAILDSNIVNIvLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCG 92
Cdd:cd17477  193 ALLGAFVAGFLEGAFYSL-LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLP 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  93 LSI--SLETIVLFRVIqGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFIni 170
Cdd:cd17477  272 LVPglPLALLVLLFLW-GGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLF-- 348

                        170
                 ....*....|...
gi 507051323 171 pIGLIACVLVLIL 183
Cdd:cd17477  349 -LAAVALLFLLFL 360
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 9-157 3.08e-07

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 53.01  E-value: 3.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   9 FALFALISGFFMAILDSNIVNIVLpemTIS--FNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTI 86
Cdd:cd17336    4 FVVLLCLLGLLQGAVVSYFVSTIT---TIEkrFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323  87 SSLLCGLsisLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILS 157
Cdd:cd17336   81 GCFLLAL---PHFLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLL 148
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
67-187 3.20e-07

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 52.91  E-value: 3.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAA 146
Cdd:PRK15403  74 LSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAP 153

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 507051323 147 AIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKES 187
Cdd:PRK15403 154 IIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPET 194
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 31-184 3.51e-07

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 52.58  E-value: 3.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  31 VLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGIS 110
Cdd:cd17358   28 LMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFG 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507051323 111 AAII-VPVAMPLGlELVPKEkqgiIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFinipIGLIACVLVLILF 184
Cdd:cd17358  108 GGAAsVVVPVYIA-EIAPKN----VRGALGSLNQLLVNIGILLGYVLGSFLPWRTLAL----IGAIPPVVFLILL 173
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 39-184 3.58e-07

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 52.62  E-value: 3.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  39 FNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFvftISSLLCGL-----SISLETIVLFRVIQGISAAI 113
Cdd:cd17318   51 FDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSIL---ITALLTLLtplaaRGGYGALIVLRILQGLAQGV 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323 114 IVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILF 184
Cdd:cd17318  128 TFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV 198
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 64-192 1.10e-06

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 50.69  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  64 MAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGI-------SAAIIVpvamplglELVPKEKQGIIGG 136
Cdd:cd17390   51 VGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIfkhtqslCKAYLS--------DLVSEQERSRVLG 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 507051323 137 IMGAFGGLAAAIGPALGGILS-DQLSWKWIFFINIPIGLIACVLVLILFKESYDELS 192
Cdd:cd17390  123 RFNAASSLGFILGPVVGGHLAeTDGGFYYVALLCSAIFILNAGLVWFLLSKLWDLLL 179
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 68-183 1.58e-06

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 50.45  E-value: 1.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  68 ADRFGRKKFYVIGLFVFTISSLLCGLSISLETI--------VLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMG 139
Cdd:cd17368   64 ADRIGRKPAMTLTLAIMALGTLLIALAPTYATIgiaapllvLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQS 143

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 507051323 140 AFGGLAAAIGPALGGILS-----DQLS---WKWIFFINIPIGLIACVLVLIL 183
Cdd:cd17368  144 ASQQVAIVAGALVGYLLSltltaEALAewgWRIPFFIGLLIIPLGLWLRRSL 195
MFS_FucP_like cd17394
Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; ...
 11-156 1.60e-06

Fucose permease and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of L-fucose permease (also called L-fucose-proton symporter) and similar proteins such as glucose/galactose transporter and N-acetyl glucosamine transporter NagP. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. Glucose/galactose transporter functions in the uptake of of glucose and galactose. The FucP-like subfamily belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340952 [Multi-domain]  Cd Length: 401  Bit Score: 50.68  E-value: 1.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLL 90
Cdd:cd17394    1 LALVTSLFFLWGFATNLNDILIPQFKNIFDLSNFQASLVQFAFFGAYFIMAIPAGMLIKRYGYKKGILLGLGLYAIGALL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507051323  91 CGLSISLETIVLFRV---IQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGIL 156
Cdd:cd17394   81 FIPAASLRTYGLFLIalfVLASGLALLQTAANPYVTVLGPEETAARRLNLAQAFNSLGSTIAPLFGSYL 149
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 33-158 1.72e-06

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 50.32  E-value: 1.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  33 PEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAA 112
Cdd:cd17313  270 SAASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWA 349

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 507051323 113 IIVPVAMPLGLELVPK--EKQGIIGGIMGAFGGLAAAIGPALGGILSD 158
Cdd:cd17313  350 TININPYPLVSDYHSEsgRGQGTDTGLLNLAISLAQILVSLLAGPIID 397
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 269-409 1.87e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 269 LLLFIVGMGMMNIIFLLSFFLTQVqGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYSFTtM 348
Cdd:cd17325    3 LALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA-F 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323 349 STDFTSLdYIWRVaVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAV 409
Cdd:cd17325   81 ATSYWQL-LLARF-LQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL 139
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
265-415 2.83e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 49.88  E-value: 2.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 265 SVGNLLLFIVGMGMM---NIIFLLSFFLTQVQ---GISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLL 338
Cdd:COG2223    1 SGRWRVLLLATLAFFlafGVWYLWSVLAPPLAeefGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507051323 339 AVTTYsFTTMSTDFTSLdYIWRVaVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALLN 415
Cdd:COG2223   81 GIGLL-LLALAVSYWLL-LLLGL-LLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA 154
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 67-181 2.84e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 49.48  E-value: 2.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFrVIQGISAAIIVPVAMPLGLELVPkEKQGIIGGIMGAFGGLAA 146
Cdd:cd17478  253 LSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVVLAQELLP-GNVGLASGLMMGLSFGLG 330

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 507051323 147 AIGPALGGILSDQLSWKWIFFINIPIGLIACVLVL 181
Cdd:cd17478  331 GIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 69-414 5.08e-06

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 49.06  E-value: 5.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  69 DRFGRKKFYVIGLFVFTISSLLCGLSISLETI--------VLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGI--M 138
Cdd:cd17369   69 DRIGRKKTLVLTLLLMGIATFLIGLLPTYAQIgilapillVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFpqL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 139 GAFGGLAAAIG--PALGGILSDQ--LSWKWiffiNIPIgLIACVLVLI-LF-----KES--YDELSEKkidwlgvllssl 206
Cdd:cd17369  149 GAPVGLLLATGvfLLLSALLSDEafLSWGW----RIPF-LLSAVLVAVgLYirlrlEETpvFRRAKEA------------ 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 207 flftlvlallkvnddswnkeyiillfvisiisfisfiniEKKSKYPILPLWLFNNRQFSVGNLLLF-IVGMGMMNIIFLL 285
Cdd:cd17369  212 ---------------------------------------GQVVRAPLVEVLRRHWRALLLAIGLRLaENVLFYLFTTFAL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 286 SfFLTQVQGISE---LKAGLIISVLAIFSMIVTTIMtpiATKKGSRWIGMAGMLLLAVTTYS-FTTMSTDFTSLDYIWRV 361
Cdd:cd17369  253 S-YATQTLGVDRstvLLAVLIASVVAAITIPLFGWL---SDRVGRRPVYLAGALLAALFAFPfFWLLDTGSTWLIVLAAV 328

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 507051323 362 AVGGVGTGCTLAPIST--TAILSVPVNKSGMAssitnISRTIGSIL--GVAVLVALL 414
Cdd:cd17369  329 VVLGVLHGMMYGPQAAflAELFPTRVRYTGAS-----LGYQLGAILggGFAPLIATA 380
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 13-184 5.30e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 48.73  E-value: 5.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  13 ALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVC-LLPMAKLADRFGRKKFYVIGLFVFTISSLLC 91
Cdd:cd17330  179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  92 GLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFfinip 171
Cdd:cd17330  259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF----- 333

                        170
                 ....*....|...
gi 507051323 172 igLIACVLVLILF 184
Cdd:cd17330  334 --LLAAGLLLIAL 344
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 10-156 6.25e-06

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 48.79  E-value: 6.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFAL-ISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:cd17403    4 FLFFLcIFAFLQGMVVNGFVNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGIGS 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507051323  89 LLCGLSislETIVLF--RVIQGISAAIIVpvamPLGL----ELVPKEKQGIIGGIMGAFGGLAAAIGPALGGIL 156
Cdd:cd17403   84 LVFALP---HFTVFIlaQLLHGAGATPLY----TLGVtyldENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFL 150
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 66-188 6.34e-06

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 48.72  E-value: 6.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  66 KLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGiiGGIMG-AFGGL 144
Cdd:cd17384   53 PLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAGMGMLASLYPDDKER--GKAMGiALGGL 130

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 507051323 145 AAA--IGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKESY 188
Cdd:cd17384  131 ALGvlVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQPSV 176
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 10-184 7.17e-06

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 48.45  E-value: 7.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   10 ALFALISGFFMAILDSNIVNIVLPEM-TISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:TIGR00886   2 NLFFSWFGFFLSFLVWFAFSPLAVFLiKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPC 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   89 LLCGLS-ISLETIVLFRVIQGISAAIIVPvAMPLGLELVPKEKQGIIGGIMGAFG----GLAAAIGPAL------GGILS 157
Cdd:TIGR00886  82 LWAGLAvQSYSVLLLIRLFIGIAGGSFAS-CMPWISFFFPKKIQGTALGLAAGWGnmggGVAQFVMPPIigslifGGGQP 160

                         170       180
                  ....*....|....*....|....*..
gi 507051323  158 DQLSWKWIFFInIPIGLIACVLVLILF 184
Cdd:TIGR00886 161 AHLAWGWAFVI-VPAGILLLPALLIFF 186
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 39-187 8.73e-06

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 48.00  E-value: 8.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  39 FNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVA 118
Cdd:cd17475   26 LHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGG 105

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507051323 119 MPLGLELVPKEKQGIIGGI------MGafGGLAAAIGPALGGilsdQLSWKWIFFINIPIGLIACVLVLILFKES 187
Cdd:cd17475  106 GRAIMRWFPPRERGLAMGIrqtgvpLG--GALAAALLPPLAL----HYGWRAAFVVAGLVSILAAVLFWLFYREP 174
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 6-156 9.89e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 47.96  E-value: 9.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   6 THSFALFALISGFFMAILDSniVNIVLPEMT-ISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVF 84
Cdd:cd17503  177 DRNFTLGLLLSFLLGLGLFG--AMFLLPLYLqNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLL 254

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507051323  85 TISSLLCGL---SISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGIL 156
Cdd:cd17503  255 ALGTLLLAFltpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 10-185 1.35e-05

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 47.60  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSL 89
Cdd:cd17332  222 PFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLL 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  90 LCGL--SISLETIVLFRVIQGISAAIIVPVAMPL-------GLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGIL---- 156
Cdd:cd17332  302 LLFFlpPGNLVLILVLAVLAGIGYGGANLLPWAMladvidyGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLIlsla 381

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 507051323 157 ------SDQLSWK----WIFFINIPIGLIACVLVLILFK 185
Cdd:cd17332  382 gyvanaAAQSASAlngiRLLIAVLPAVLLLLALILMSFY 420
MFS_ProP cd17366
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ...
 67-176 1.80e-05

Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340924 [Multi-domain]  Cd Length: 377  Bit Score: 46.97  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGLSISLETI--------VLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGI- 137
Cdd:cd17366   63 LGDKYGRQKVLAITIILMAASTFCIGLLPTYATIgvwapillLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWl 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 507051323 138 -MGAFGG--LAAAIGPALGGILSDQ--LSWKW--IFFINIPIGLIA 176
Cdd:cd17366  143 eFGTLAGfiLGAGLVTLLTLLLTEAqmLDWGWriPFLIAAPLGLVG 188
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 10-175 6.25e-05

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 45.42  E-value: 6.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFALISGFFMAILDSNIVNIVLPEM--TISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTIS 87
Cdd:cd17362    3 ALGGLLFGYDIGATSGALLSITSPALsgTDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  88 SLLCGLSISLETIVLFRVIQGIS---AAIIVPVAMPlglELVPKEKQG---------IIGGIMGAFgGLAAAIGPALGGi 155
Cdd:cd17362   83 SLVTGLAPSYPVLLVGRLIYGVGiglAMHAAPVYIA---ETSPSHIRGllvslkelfIVLGILLGY-VSGYAFADVVGG- 157

                        170       180
                 ....*....|....*....|
gi 507051323 156 lsdqlsWKWIFFINIPIGLI 175
Cdd:cd17362  158 ------WRYMYGLAAPPALL 171
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 12-185 6.33e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 45.24  E-value: 6.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  12 FALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLC 91
Cdd:cd17380    2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  92 GLSI--SLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFIN 169
Cdd:cd17380   82 PLLAysSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFF 161

                        170
                 ....*....|....*.
gi 507051323 170 IPIGLIACVLVLILFK 185
Cdd:cd17380  162 GLLGLLWALVWLIYLP 177
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 52-165 7.58e-05

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 45.03  E-value: 7.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  52 SYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQ 131
Cdd:cd17379   41 SLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYR 120

                         90       100       110
                 ....*....|....*....|....*....|....
gi 507051323 132 GIIGGIMGAFGGLAAAIGPALGGILSdqlSWKWI 165
Cdd:cd17379  121 RTVGIVYQMFFTLGLLILPGIAYFIP---HWRWL 151
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 42-183 9.03e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.99  E-value: 9.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  42 SVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLL-CGLSISLETIVLFRVIQGISAAIIVPVAMP 120
Cdd:cd17371  243 SFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLyFFLPLSPTLILILGFPLGFFASGPFSGMGA 322

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507051323 121 LGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFInipIGLIACVLVLIL 183
Cdd:cd17371  323 YLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAV---FAAVYYIAGLVL 382
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 10-172 1.06e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 45.07  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFALISGFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSL 89
Cdd:PRK03893  21 AFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  90 LCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGG--IMG-AFGGLAAA-----IGPALGgilsdqls 161
Cdd:PRK03893 101 ACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGflISGfSIGAVVAAqvyslVVPVWG-------- 172

                        170
                 ....*....|..
gi 507051323 162 WKWIFFINI-PI 172
Cdd:PRK03893 173 WRALFFIGIlPI 184
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 17-183 1.12e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 44.50  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  17 GFFMAILDSNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFyVIGLFVFTISSLLCGLSIS 96
Cdd:cd17365  179 TFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRV-LALFFALGAVSLALLGVSP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  97 LETIVLFRVIQGISAAIIVPVAMPLGL--ELVPKEKQGIIGGIMGAFGGLAAAIGPALGG-ILSDQLSWKWIFFINIPIG 173
Cdd:cd17365  258 ASLVLLYVLVFLAGACVNGAQVGLYALaaRFYPTEVRATGVGWALGVGRLGAILGPLLGGlLLAAGLGPESVFLALAIPA 337

                        170
                 ....*....|
gi 507051323 174 LIACVLVLIL 183
Cdd:cd17365  338 ALGALAVLLL 347
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 64-183 1.32e-04

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 44.59  E-value: 1.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  64 MAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETI--------VLFRVIQGISAAIIVPVAMPLGLELVPKEKQG--- 132
Cdd:cd17367   60 FGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATIgiwapiilLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGfys 139

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 133 ------IIGGIMgafggLAAAIGPALGGILS-DQL-SWKW-IFFInipIGLIACVLVLIL 183
Cdd:cd17367  140 sfqyvtLIGGQL-----LALGVLLVLQHTLGeDQMaAWGWrIPFL---LGGVLAVVVLWL 191
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 67-184 1.85e-04

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 44.13  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKK-FYVIGLFVFTISSLLCG------LSISLETIVLFRVIQGISAAI-IVPVaMPLGLELVPK-------EKQ 131
Cdd:cd17385  259 LSDKKKIPKwLMVIGSIITGVGFLLLGpapllpIKSELWMVIIGLVLLGLSLGAaLVPT-FPELLNCAREygfpdnlSTY 337

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 507051323 132 GIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILF 184
Cdd:cd17385  338 GLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 269-407 3.06e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 43.31  E-value: 3.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 269 LLLFIVGMGMMNIIFLLSFFLTQVQ---GISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTySF 345
Cdd:cd17324    2 LALALAAFAIGTTEYVIQGLLPDIArdfGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN-LL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507051323 346 TTMSTDFTSLdYIWRVAVGGVGTGCTlAPISTTAILSVPVNKSGMASSITNISRTIGSILGV 407
Cdd:cd17324   81 AALAPSFALL-LLARALAGLAHGGFW-AIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGR 140
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 272-416 3.19e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.97  E-value: 3.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 272 FIVGMGMMNIIFLLSFFLTQVQGiSELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYSFTTmSTD 351
Cdd:cd17489    6 FFFFLSFYLLLPVLPLYAHDLGG-SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL-ATS 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507051323 352 FTSLdYIWRVaVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALLNN 416
Cdd:cd17489   84 VALL-LVLRL-IHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQH 146
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 12-184 3.80e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 43.03  E-value: 3.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  12 FALISGFFMAiLDSNIVNIVLPEMTISFNTSVEHISW---VINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISS 88
Cdd:cd17360    1 FAGIGGFLFG-YDTGVISGALLYIKDDLGEVVLSTGWqelIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  89 LLCGLSISLETIVLFRVIQGIS---AAIIVPVAMPlglELVPKEKQG---IIGGIMGAFGGLAAAIgpaLGGILS-DQLS 161
Cdd:cd17360   80 IVMAAAPNKEVLIVGRVLVGLGvgiASMTVPLYIA---EAAPPRIRGrlvTINVLFITGGQFVAYV---INGAFSyLPGG 153

                        170       180
                 ....*....|....*....|...
gi 507051323 162 WKWIFfiniPIGLIACVLVLILF 184
Cdd:cd17360  154 WRWML----GLAAVPAVLQFIGL 172
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 269-380 4.44e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 42.53  E-value: 4.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 269 LLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSR-WIGMAGMLLLAVTTYSFTT 347
Cdd:cd17471    3 LATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRkPLILLALLAGALGYLLFAF 82

                         90       100       110
                 ....*....|....*....|....*....|...
gi 507051323 348 MStdftslDYIWRVAVggvgtGCTLAPISTTAI 380
Cdd:cd17471   83 LR------NYWVLLLV-----GVVLLSLGAAAF 104
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 67-187 4.83e-04

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 42.60  E-value: 4.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIG-LFVFtISSLLCGLSI---SLETIVLFRVIQGISAAI---IVPvaMPLGlELVPKEKQGIIGGIMG 139
Cdd:cd17432   73 LVIRLGRKGTLLLNnIFAI-VAAILMGLSKiakSFEMIIVGRFLVGINAGIslnVVP--MYLG-ESAPKNLRGAVGLVPA 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 507051323 140 AFGGLAAAIGPALG--GILSDQLSWKWIF-FINIPIGLIacVLVLILFKES 187
Cdd:cd17432  149 IFITLGILLGQVLGlrELLGNEEGWPLLLaLTGVPALLQ--LLTLPFFPES 197
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
 37-188 4.98e-04

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 42.72  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  37 ISFNTSVEHISWvinsYNLAFAVCLLPMAKLADRFGRKKFYVI--GLFVFTISSLLCGLSISLETIVLFRVIQGISAAII 114
Cdd:cd17396  235 MGEAESLKLISY----YSMGSLVCVFITAVLLKRYVRPIWILVlyPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGV 310

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507051323 115 VPVAMPLGLELVPKEKqGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKESY 188
Cdd:cd17396  311 LQLGLTLMAEFFPKGK-GKVTGIYMIASSLANFVIPLITGIIASAIGIAYIFLFDFGIALLGLLLAIFVFIRYR 383
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 258-406 5.12e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 42.54  E-value: 5.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 258 LFNNRQFSVGNLLLFIVGMGMMNIIFLLSFFLTQvQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLL 337
Cdd:cd17352  179 LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKS-LGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTL 257

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 338 LAVTTYSFT-TMSTDFTSLdYIWRVAVgGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILG 406
Cdd:cd17352  258 LILGLSLLAfPLATTYVGL-IVFSVLF-GFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVG 325
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 10-423 5.26e-04

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 42.68  E-value: 5.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  10 ALFALISGFFMAILDSNIVNIVLPEMTISFN-----TSVEHISWVINsynlafAVCLLPMAKLADRFGRKKFYVIGLFVF 84
Cdd:cd17322    4 LFFSLFLCGFAIGLDGQIRYSYQAYATSSFSkhsllSTINVVNNIVS------AVSQPPYAKLSDVFGRLELFLVSLLLY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  85 TIssllcGLSISLETivlfRVIQGISAAIIVPVAMPLGLELVpkeKQGIIG--------GIMGAFGGLAAAIGPALGGIL 156
Cdd:cd17322   78 VV-----GTIIMAAS----TNVQTYAAGSVFYNAGYTGLNLL---LTLILAdfsslknrGFASAIPSLPYIITTWIGGNI 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 157 SD----QLSWKW---IFFINIPIGLIACVLVLILFK------ESYDELSEK------------------KIDWLGVLLSS 205
Cdd:cd17322  146 AQaalpNSNWRWgygMWAIILPLSSLPLVLCLLYMQrkarkdGEIKELKNQeteeqtgglsqnlvklfwKLDIFGVILLT 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 206 LFLFTLVLALLKVNDDS--WNKEYIILLFVISIISFISFINIE-KKSKYPILPLWLFNNRQFSVGNLLLFIVGMGM-MNI 281
Cdd:cd17322  226 AGLGLILVPLTLAGGAKskWKNSSIIAMIVLGGVLLVAFLLWEaKFAKYPFLPFRLLKDRTILAACLIDFFYFFSYyIFS 305

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 282 IFLLSfFLTQVQGISELKAGLIISVLAiFSMIVTTIMTPIATKKGSRW---------IGMAGMLLLavttYSFTTMSTdf 352
Cdd:cd17322  306 DYLYT-VLQVAVGESITSATRITNLYS-FVSTVAGIFVGFLIRKTRRYkvlviigvpLYIVGMGLL----IRYRGGSG-- 377

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323 353 TSLDYIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALLNNQLESQLN 423
Cdd:cd17322  378 SHGGIIGALILIGIGGGLFTYPVQVSVQASVSHQEMAVVTALLLTVYSIGGAVGAAISGAIWTQTLPKKLL 448
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 246-414 5.30e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 42.59  E-value: 5.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 246 EKKSKYPILPLW--LFNNRQF---SVGNLLLFIVGMGMMNIIFllsFFLTQVQGiSELKAGLIISVLAIFSMIVTTIMTP 320
Cdd:cd17332  203 EEKSKLPLLKSLkaLLKNRPFlilLLAYLLYFLAFNIVNTVLV---YYFKYVLG-GRAELVLLLLLILSGALLALLPWPP 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 321 IATKKGSRWIGMAGMLLLAVTTYSFTTMSTDFTSLDYIWRVAVG-GVGTGCTLAPISTTAI-----LSVPVNKSGMASSI 394
Cdd:cd17332  279 LKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGiGYGGANLLPWAMLADVidygeLKTGKRREGIFYSV 358

                        170       180
                 ....*....|....*....|
gi 507051323 395 TNISRTIGSILGVAVLVALL 414
Cdd:cd17332  359 MTFFRKLGLALAGALVGLIL 378
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 65-183 5.70e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.18  E-value: 5.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  65 AKLADRFGRKKFYVIGLFVFTISSLLCGL-SISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGG 143
Cdd:cd17504  238 GRLIARVGPRRVLLIGLVISAVGLLLLALlHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRT 317

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 507051323 144 LAAAIGPALGGILSDQLSwKWIFFINIP----------IGLIACVLVLIL 183
Cdd:cd17504  318 IGSAIGPAIAGAILTTYT-VSITSGGVPtegayvlaflIGAALALAALLL 366
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 46-184 5.87e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 42.19  E-value: 5.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  46 ISWVINSynLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLEL 125
Cdd:cd17335  237 LLWTVGV--VSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAA 314

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 126 VPKEKQGIIGGIMGA-FGGLAAAIGPALGGILSDQLSWKWIFFINipigLIACVLVLILF 184
Cdd:cd17335  315 APPGLRATAQGLLQGlYFGLGGGLGSLIGGYLYEAFGARTTFRFF----AIAALAGLLAF 370
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 269-417 6.73e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.16  E-value: 6.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 269 LLLFIVGMGMMNIifLLSFFLTQvQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGMAGMLLLAVTTYSFTTm 348
Cdd:cd17477    5 VALLGLGSGLLLP--LLSLRLER-EGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL- 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 349 sTDFTSLDYIWRvAVGGVGTGCTLApISTTAILSVPVNKS-GMASSITNISRTIGSILGvAVLVALLNNQ 417
Cdd:cd17477   81 -TDSPWVWFLLR-FVMGIGLAGLFV-VSESWLNALATNENrGRVLGLYSTVLGLGFALG-PLLLALVGTA 146
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 265-410 7.23e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 42.21  E-value: 7.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 265 SVGNLLLF--IVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIATKKGSRWIGM-AGMLLLAVT 341
Cdd:cd17331  208 GVAFLLLVklLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLkLSVALLAIG 287

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507051323 342 TYSFTTMSTDFTSLdyiwrVAVGGVGTGCTLAPISTTAILSVPVNKS------GMASSITNISRTIGSILGVAVL 410
Cdd:cd17331  288 YLLLAFVTTVWQLL-----VLLLPLVIGGSVLYTVITSLLTKAVPPEdtgtalGLSHALFSLVRTVSPTIGGALL 357
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 47-183 8.26e-04

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 41.94  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   47 SWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSI---SLETIVLFRVIQGISAAIIVPVAMPLGL 123
Cdd:TIGR00879  74 GLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAfalSVEMLIVGRVLLGIGVGIASALVPMYLS 153

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507051323  124 ELVPKEKQGIIGGI---MGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLIL 183
Cdd:TIGR00879 154 EIAPKALRGALTSLyqlAITFGILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFL 216
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 17-109 8.74e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 41.88  E-value: 8.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  17 GFFMAILDSNIVNIVLPEMTISFNTSVEHI-----SWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLC 91
Cdd:cd17364    7 GFFTDAYDLFSISLVTKILGRLYYGGKGSLpsgvsGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILS 86

                         90       100
                 ....*....|....*....|....
gi 507051323  92 GLSIS------LETIVLFRVIQGI 109
Cdd:cd17364   87 ALSPGstplgvMGWLIFFRFLLGI 110
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 64-406 8.93e-04

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 41.76  E-value: 8.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  64 MAKLADR-FGRKKFYVIGLFVFTISSLLCGLSISLETIVLFR-VIQGISAAIIvPVAMPLGLELV---PKEKQGIIGGIM 138
Cdd:cd17471   52 LGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGvVLLSLGAAAF-PQLFALAREYAdrsSGRDATLFNSVL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 139 GAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLILFKESYDELSEKKidwlgvllsslflftlvlallkv 218
Cdd:cd17471  131 RAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKAT----------------------- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 219 nddswnkeyiillfvisiisfisfINIEKKSKYPILPLWLfnnrqFSVGNLLLFIV-GMGMMNiiflLSFFLTQVQGISE 297
Cdd:cd17471  188 ------------------------PASSLVKAPVNRRLLL-----LFAAFTLLFAAnSMYIIA----MPLYVTNELGGSE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 298 LKAGLIISVLA---IFSMIVTTIMtpiATKKGSRWIGMAGMlLLAVTTYSFTTMSTdftsldYIWRVAVGGVGTGCTLAP 374
Cdd:cd17471  235 SWVGLLFGLAAaleIPIMLLAGLL---AKRFGKRRLLLAGF-LAGVLFYLGLALAT------SLWQLIALQLLNAIFIGI 304

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 507051323 375 ISTTAIL----SVPvNKSGMASSITNISRTIGSILG 406
Cdd:cd17471  305 TAGLGISyfqdLMP-GQPGLATTLYSNASRIGSLLG 339
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 49-190 8.96e-04

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 42.04  E-value: 8.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   49 VINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLS--ISLETIVLFRVIQGISAAIIVPVAMPLGLELV 126
Cdd:TIGR00894  81 ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAagGGIALVVFCRVIQGLAQGSVSPATHKIIVKWA 160

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507051323  127 PKEKQGIIGGIMGAfgglAAAIGPALGGILSDQLSWKW-----IFFInipIGLIACVLVLILFKESYDE 190
Cdd:TIGR00894 161 PPKERSRLLGMSTS----GFQLGTFIFLPISGWLCESWggwpmIFYV---FGIVGCAWSLLWFVFPADD 222
emrD PRK11652
multidrug transporter EmrD;
31-187 8.97e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 41.82  E-value: 8.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  31 VLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGIS 110
Cdd:PRK11652  30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 111 AAI------IVPVAMPLGLELVpKEKQGIIGGIMgaFGGLAAaigPALGGILSDQLSWKWIFFINIPIGLIACVLVLILF 184
Cdd:PRK11652 110 TGVggvmarTLPRDLYEGTQLR-HANSLLNMGIL--VSPLLA---PLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWM 183


                 ...
gi 507051323 185 KES 187
Cdd:PRK11652 184 PET 186
PRK10642 PRK10642
proline/glycine betaine transporter ProP;
67-179 1.06e-03

proline/glycine betaine transporter ProP;


Pssm-ID: 182611 [Multi-domain]  Cd Length: 490  Bit Score: 41.62  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGLSISLETI--------VLFRVIQGIS-------AAIIVPvamplglELVPKEKQ 131
Cdd:PRK10642  80 LGDKYGRQKILAITIVIMSISTFCIGLIPSYATIgiwapillLLCKMAQGFSvggeytgASIFVA-------EYSPDRKR 152

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 507051323 132 G----------IIGGIMGAfgGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVL 179
Cdd:PRK10642 153 GfmgswldfgsIAGFVLGA--GVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYL 208
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 67-188 1.30e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 41.12  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAA 146
Cdd:cd17374   58 LSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQ 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 507051323 147 AIGPALGGILSDqlsWKWIFF-INIPIGL----------IACVLVLILFKESY 188
Cdd:cd17374  138 MLLAGLAYAIRD---WRLLQLvVSVPFFLfflyswwlpkRTLILSFVWFANSF 187
MFS_4 pfam06779
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ...
 5-161 1.41e-03

Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.


Pssm-ID: 399632 [Multi-domain]  Cd Length: 365  Bit Score: 41.20  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323    5 LTHSFALFALISGFFMAILDSNIVNIVLPEM--TISFNTSVEHISWVInsYNLAFAVCLLPMAKLADRFGRKKFYVIGLF 82
Cdd:pfam06779 189 LQRSLPLWILTLAYGLAGFGYIITATFLPAMarDGFGGPAAAALFWSL--FGLAAALGVLVWLRAAKRWGTRPALTAALL 266

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507051323   83 VFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFgGLAAAIGPALGGILSDQLS 161
Cdd:pfam06779 267 IQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAPRRLLGLMTASF-GIGQILGPLLASLLTAATG 344
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 7-184 1.51e-03

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 41.42  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323    7 HSFALF--ALISGFFmaildsnivNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVF 84
Cdd:pfam03137   6 LSLLGLaqALVSGYF---------NSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLM 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323   85 TISSLLCGLsisLETIVLF--RVIQGISAAIIvpvaMPLGL----ELVPKEKQGIIGGIMGAFGGLAAAIGPALGGIL-- 156
Cdd:pfam03137  77 GLGSLLFAL---PHFLSFFlgQLLLGIGGTPI----YTLGIsyidDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLClr 149

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 507051323  157 ------SDQLS-----------WkWIFFinIPIGLIACVLVLILF 184
Cdd:pfam03137 150 iyvdigKVSITltpkdprwvgaW-WLGF--LIAGLLLLLTAIPFF 191
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 285-413 1.65e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 41.07  E-value: 1.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 285 LSFFLTQVQGISELKAGLIISVLAIfSMIVTTIMTPIATKK-GSRWIGMAGMLLLAVTTYSfTTMSTDFTSLDYIwrVAV 363
Cdd:cd17475   18 LAPFLQEDLHLSLAQVGLLLSALNL-GVAVSMLPAGWLLDRfGERRVLAVGLLLMGAAALL-MALVGSYPVLLVL--LFL 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 507051323 364 GGVGTGCTLaPISTTAILS-VPVNKSGMASSITNISRTIGSILGVAVLVAL 413
Cdd:cd17475   94 VGAGYGSVQ-PGGGRAIMRwFPPRERGLAMGIRQTGVPLGGALAAALLPPL 143
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 67-182 1.79e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 40.67  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAA 146
Cdd:cd17331  267 LTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVR 346

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 507051323 147 AIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLI 182
Cdd:cd17331  347 TVSPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
260-415 1.82e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.04  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 260 NNRQFSVGNLLLFIVGMGMMNIIF-----LLSFFLTQVQGISELKAGLIISVLAIFSMIVTTIMTPIA----TKKGSR-- 328
Cdd:COG2211    3 AKKKLSLKEKLAYGLGDLGLNLAFgllsaYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSdrtrTRWGRRrp 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 329 WIgMAGMLLLAVTTY-SFTTMSTDFTSLD---YIWRVAVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSI 404
Cdd:COG2211   83 WI-LIGAIPLALSFVlLFTAPDLSPTGKLiyaLVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGL 161

                        170
                 ....*....|.
gi 507051323 405 LGVAVLVALLN 415
Cdd:COG2211  162 LASVLPPPLVA 172
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 67-201 1.96e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 40.72  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAiIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAA 146
Cdd:cd17389   87 ASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKG-NVSLSTAIVADVTSPKKRSKGMALIGVAFSLGF 165

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 507051323 147 AIGPALGGILSDQLSWKWIFFINIP----IGLIACVLVLILFKesYDELSEKKIDWLGV 201
Cdd:cd17389  166 IIGPMIGAYFASFTRSLGEVFFSMPalfaLVLALADLLFIFFF--LPETLPSNLRRLGL 222
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 11-181 2.05e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 40.47  E-value: 2.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  11 LFALISGFFMAILDSNIVNIvlpemtiSFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKkfYVIGLFVFTISSL- 89
Cdd:cd17314  216 FLVLIGGFLFIANMASLVRS-------LQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGR--LSTLSILLTILGLg 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  90 LCGLSISLE----TIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQL-SWKW 164
Cdd:cd17314  287 LCAFLFLLKmtpvGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTpSYIS 366

                        170
                 ....*....|....*..
gi 507051323 165 IFFINIPIGLIACVLVL 181
Cdd:cd17314  367 AVYIYAVIVFLASAILL 383
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 25-183 2.96e-03

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 40.15  E-value: 2.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  25 SNIVNIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLF- 103
Cdd:cd17381   46 SSSPSVEHNETGKKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIa 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 104 -RVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLI 182
Cdd:cd17381  126 vRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIW 205


                 .
gi 507051323 183 L 183
Cdd:cd17381  206 L 206
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 29-183 3.18e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 39.90  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  29 NIVLPEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVL-FRVIQ 107
Cdd:cd17353   23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLgYGVLG 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507051323 108 GISAAIIVPVAMPLGLELVPkEKQGIIGGIMGAFGGLAAAIGPALGGILSDQLSWKWIFFInipIGLIACVLVLIL 183
Cdd:cd17353  103 GIGAGIGYITPVSTAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLI---LGIIFLIIIVIG 174
PRK10489 PRK10489
enterobactin transporter EntS;
67-156 3.37e-03

enterobactin transporter EntS;


Pssm-ID: 236700 [Multi-domain]  Cd Length: 417  Bit Score: 39.96  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYV-------IGLFVFTISSLLCglSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMG 139
Cdd:PRK10489  75 LADRYDRKKLILlargtcgLGFIGLALNAFLP--EPSLLAIYLLGLWDGFFGSLGVTALLAATPALVGRENLMQAGAITM 152

                         90
                 ....*....|....*..
gi 507051323 140 AFGGLAAAIGPALGGIL 156
Cdd:PRK10489 153 LTVRLGSVISPALGGLL 169
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 67-183 5.20e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 39.46  E-value: 5.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADR--FGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGGL 144
Cdd:cd17352  241 LADKprIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGL 320

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 507051323 145 AAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLIL 183
Cdd:cd17352  321 AALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFL 359
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
269-415 5.37e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.47  E-value: 5.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 269 LLLFIVGMGMMNIIFLLSFFLTQVQ---GISELKAGLIISvLAIFSMIVTTIMTPIATKK-GSRWIGMAGMLLLAVTTYS 344
Cdd:COG2807   21 LAIVLVALNLRPAITSVGPLLPEIRadlGLSATQAGLLTT-LPLLAFGLFAPLAPRLARRfGLERTLLLALLLLAAGLLL 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323 345 FtTMSTDFTSLdYIWRvAVGGVGTGCTLAPISTTAILSVPvNKSGMASSITNISRTIGSILGVAVLVALLN 415
Cdd:COG2807  100 R-SLAPSVALL-LAGT-ALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAA 166
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
 16-183 5.77e-03

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 39.25  E-value: 5.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  16 SGFFMAILDSNIVNIVL----PEMTISFNTSVEHISWVINSYNLAFAVCLLPMAKLADRFGRKKFYVIGLFVFTISSLLC 91
Cdd:cd17396    3 LGLYFNYFVHGMGVIILaqnmSSLSEKWHTDVAGVAYVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  92 GLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKeKQGIIGGIMGAFGGLAAAIGPAL-GGILSDQLSWKWIFFinI 170
Cdd:cd17396   83 LFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPK-ASGSANILVKAFVSFGQFLLPFIiAFLAANNLWYGWSFI--V 159

                        170
                 ....*....|...
gi 507051323 171 PIGLIACVLVLIL 183
Cdd:cd17396  160 PAAVLVLNALLLL 172
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 269-414 7.08e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 7.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323 269 LLLFIVGMGMMNIIFLLSFFLTQVQGISELKAGLIISVLAI-FSMIVTTIMTPIA----TKKGSRWIGMAGMLLLAVTTY 343
Cdd:cd17355    4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFtVGLLAFGLAQPFVgrllDRFGPRRVMLLGLLLLAAGLV 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507051323 344 SFTTMSTDFtSLDYIWRVaVGGVGTGCTLAPISTTAILSVPVNKSGMASSITNISRTIGSILGVAVLVALL 414
Cdd:cd17355   84 LLALATSLW-QLYLLWGL-LGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALI 152
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 67-183 7.13e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 38.79  E-value: 7.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  67 LADRFGRKKFYVIGLFVFTISSLLCGL-----SISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAF 141
Cdd:cd17312  242 LSDKLFGGRRAPIAVIYMLLMTLSLALfwffpHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLF 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 507051323 142 GGLAAAIGPALGGILSDQLSWKWIFFINIPIGLIACVLVLIL 183
Cdd:cd17312  322 GYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSL 363
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 65-185 9.83e-03

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 38.49  E-value: 9.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  65 AKLAD-RFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGIMGAFGG 143
Cdd:cd17378   54 GHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFV 133

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 507051323 144 LAAAIGPALGGILSDqlSWKWIFFINIPIGLIACVLVLILFK 185
Cdd:cd17378  134 LGFMSLPGIAYLNGS--SWRVLYFWTSIPALIYCILVYLFAR 173
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 66-156 9.87e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 38.22  E-value: 9.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507051323  66 KLADRFGRKKFYVIGLFVFTISSLLCGLSISLETIVLFRVIQGISAAIIVPVAMPLGLELVPKEKQGIIGGImgafGGLA 145
Cdd:cd17377   61 QLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLVAFVLLNECVGKSYWALAGSL----GGLF 136

                         90
                 ....*....|.
gi 507051323 146 AAIGPALGGIL 156
Cdd:cd17377  137 FAVGIAQYALL 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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