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Conserved domains on  [gi|507080596|ref|WP_016151350|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Enterobacterales]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-91 1.99e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 78.39  E-value: 1.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080596   6 AAMVLKELGHTTRLDIYKTLVkagRQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRTLFCHACYDNLAALIA 85
Cdd:COG0640   10 LAELFKALADPTRLRILRLLA---EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                 ....*.
gi 507080596  86 FLTEEC 91
Cdd:COG0640   87 WLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-91 1.99e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 78.39  E-value: 1.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080596   6 AAMVLKELGHTTRLDIYKTLVkagRQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRTLFCHACYDNLAALIA 85
Cdd:COG0640   10 LAELFKALADPTRLRILRLLA---EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                 ....*.
gi 507080596  86 FLTEEC 91
Cdd:COG0640   87 WLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-84 1.07e-15

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 65.94  E-value: 1.07e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507080596   6 AAMVLKELGHTTRLDIYKTLVkagRQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRTLFCHACYDNLAALI 84
Cdd:NF033788   1 LAELFKALADPTRLRILELLA---EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-69 2.36e-12

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 56.78  E-value: 2.36e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507080596    7 AMVLKELGHTTRLDIYKTLVkaGRQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGR 69
Cdd:pfam12840   1 DDVAEALADPTRLRILRALV--GDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-70 2.96e-11

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 54.61  E-value: 2.96e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507080596  10 LKELGHTTRLDIYKTLVKagrQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRT 70
Cdd:cd00090    1 LKALSDPTRLRILRLLLE---GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRR 58
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-72 4.17e-07

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 43.74  E-value: 4.17e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 507080596    30 RQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRTLF 72
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVY 50
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-91 1.99e-20

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 78.39  E-value: 1.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080596   6 AAMVLKELGHTTRLDIYKTLVkagRQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRTLFCHACYDNLAALIA 85
Cdd:COG0640   10 LAELFKALADPTRLRILRLLA---EGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAELLE 86


                 ....*.
gi 507080596  86 FLTEEC 91
Cdd:COG0640   87 WLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 6-84 1.07e-15

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 65.94  E-value: 1.07e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507080596   6 AAMVLKELGHTTRLDIYKTLVkagRQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRTLFCHACYDNLAALI 84
Cdd:NF033788   1 LAELFKALADPTRLRILELLA---EGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 7-69 2.36e-12

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 56.78  E-value: 2.36e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507080596    7 AMVLKELGHTTRLDIYKTLVkaGRQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGR 69
Cdd:pfam12840   1 DDVAEALADPTRLRILRALV--GDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
9-80 1.66e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 55.74  E-value: 1.66e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507080596   9 VLKELGHTTRLDIYKTLVkagRQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQ----GRTLFCHACYDNL 80
Cdd:COG4189   12 VLKALASETRLRILRLLA---EEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKpgkrGRQKICYLRVDKI 84
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 10-70 2.96e-11

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 54.61  E-value: 2.96e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507080596  10 LKELGHTTRLDIYKTLVKagrQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRT 70
Cdd:cd00090    1 LKALSDPTRLRILRLLLE---GPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRR 58
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
30-72 4.17e-07

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 43.74  E-value: 4.17e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 507080596    30 RQGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRTLF 72
Cdd:smart00418   8 EGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVY 50
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
2-70 2.28e-05

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 40.63  E-value: 2.28e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507080596   2 ELKIAAMVLKElghTTRlDIYKTLVKAGrqGLPVGELQQHLAIPASTLSHHLSSLISVSLVRQERQGRT 70
Cdd:COG3398   87 EKKILAYLRRE---TPR-RILLYLLENP--GATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRN 149
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
13-90 1.22e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 36.44  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080596  13 LGHTTRLDIYKTLVKAGRQGlpVGELQQHLAIPASTLSHHLSSLISVSLVRQER----------------QGRTLFCHAc 76
Cdd:COG2345   10 LADPTRRRILELLKRAGPVT--AAELAEALGLTPNAVRRHLDALEEEGLVERETerrgrgrpaklyrlteAGRARFPRA- 86

                         90
                 ....*....|....*
gi 507080596  77 YDNLA-ALIAFLTEE 90
Cdd:COG2345   87 YDDLAvALLDALREL 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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