|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
14-411 |
1.24e-89 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 277.87 E-value: 1.24e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 14 KTLTLAALGGALEFYDFIIFVFFAAVV-GELFFPADIPEwLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLS 92
Cdd:cd17369 2 RVALASLVGTAIEWYDFFIYGTAAALVfNKLFFPAVDPA-AGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 93 ILLMAIPTLAIGLLPTYASMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVV 172
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 173 ATLVNTSLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKAlAQELPVKSVVSKHKKAVVISMLLTWL 252
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQ-VVRAPLVEVLRRHWRALLLAIGLRLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 253 LSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFYHLTGSHP 332
Cdd:cd17369 240 ENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGS 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 333 QHLFLLYGLVGLCVG---VVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIAVTMLMSV--SPMAPAWYVLALS 407
Cdd:cd17369 320 TWLIVLAAVVVLGVLhgmMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAAtgSWWPVALYLAALA 399
|
....
gi 507080879 408 LVGL 411
Cdd:cd17369 400 VISL 403
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
22-411 |
4.43e-85 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 265.68 E-value: 4.43e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 22 GGALEFYDFIIFVFFAAVVGELFFPADIPEWLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTL 101
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 102 AIGLLPTYASMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSLT 181
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 182 QQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKALAqELPVKSVVSKHKKAVVISMLLTWLLSAGIVVVI 261
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKK-RGPIAETLTKHRKPFLLGLGLVIATTTTFYLIT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 262 LMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSW-FFYHLTGSHPQHLFLLYG 340
Cdd:TIGR00883 240 TYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVpLLMALLDSGSFTLFFFLV 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507080879 341 LVGLCVG--VVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIAVTML--MSVSPMAPAWYVLALSLVGL 411
Cdd:TIGR00883 320 LGMALIGgmYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALvaMTGDWYAIGYYLAALALIGL 394
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
19-411 |
1.24e-72 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 233.81 E-value: 1.24e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 19 AALGGALEFYDFIIFVFFAAVVGELFFPADiPEWLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAI 98
Cdd:cd17368 4 ATSGNALEFFDFGVYGFFAVYIGRLFFPSG-SEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 99 PTLAIGLLPTYASMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNT 178
Cdd:cd17368 83 GTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 179 SLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMqQRKALAQELpvKSVVSKHKKAVVISMLLTWLLSAGIV 258
Cdd:cd17368 163 TLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLER-KARPTRREL--FALLANNRRIILLGMLLVAGSTVTFY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 259 VVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFYHLTGSHPQHLFLL 338
Cdd:cd17368 240 FTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFGRLL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507080879 339 YGLVGLCV---GVVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIAVTMLMSV--SPMAPAWYVLALSLVGL 411
Cdd:cd17368 320 LVLLVLSFffgMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELtgSPLAPAWYLMGAALLGL 397
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
16-415 |
1.94e-68 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 221.32 E-value: 1.94e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 16 LTLAALGGALEFYDFIIFVFFAAVVGELFfpadiPEWLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILL 95
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 96 MAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATL 175
Cdd:cd17316 76 FGLATLLIGLLPTPILLLVL--------RFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 176 VNTSLTQqavhDYGWRIPFLLGGVFGLVAMYLRRWlqetpiflemqqrkalaqelpvksvvskhkkaVVISMLLTWLLSA 255
Cdd:cd17316 148 LIPLLSG----DWGWRILFLIGALPALLALLLRRR--------------------------------TLLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 256 GIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSW-FFYHLTGSHPQH 334
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALpLFYLLSGSPTLL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 335 LFLLYGLVGLCVGVVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIAVTMLMSV-SPMAPAWYVLALSLVGLGL 413
Cdd:cd17316 272 LLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTgGTGVPALILALLAIVALIV 351
|
..
gi 507080879 414 GI 415
Cdd:cd17316 352 AL 353
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
19-411 |
1.00e-66 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 218.32 E-value: 1.00e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 19 AALGGALEFYDFIIFVFFAAVVGELFFPADIPEwLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAI 98
Cdd:cd17367 4 GSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPT-VALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 99 PTLAIGLLPTYASMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNT 178
Cdd:cd17367 83 GSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQH 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 179 SLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKAlAQELPVKSVVsKHKKAVVISMLLTWLLSAGIV 258
Cdd:cd17367 163 TLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNE-ASAGTLRELR-RHPRELLLVVGLTAGGTLAFY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 259 VVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFYHLTGSHPQHLFLL 338
Cdd:cd17367 241 TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAF 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507080879 339 YG-LVGLCVGVVGAVPYVMVRA--FPAEVRFTGISFSYNVSYAIFGGLTP-IAVTMLMSVSPMAPAWYVLALSLVGL 411
Cdd:cd17367 321 ALvLVGLVFLSGYTSINAVVKAelFPTHVRALGVGLPYALAVAIFGGTAPyVALWLKSIGHEWVFFWYVAGLIAISL 397
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
19-419 |
8.78e-65 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 212.60 E-value: 8.78e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 19 AALGGALEFYDFIIFVFFAAVVGELFFPADIPEWlRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAI 98
Cdd:cd17366 4 AALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTA-QLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 99 PTLAIGLLPTYASMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNT 178
Cdd:cd17366 83 STFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 179 SLTQQAVHDYGWRIPFLLGGVFGLVAMYLRR-WLQETPIFLEMQqrkalaqelpvksvvskhkkaVVISMLLTWLlsagi 257
Cdd:cd17366 163 LLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRpLLICIGLVLVFN---------------------VTNYMLLSYM----- 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 258 vvvilmsPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFYHLTGShpQHLFL 337
Cdd:cd17366 217 -------PSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLMNS--GSIAA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 338 LygLVGLCVGVVGAVPYVMVRA------FPAEVRFTGISFSYNVSYAIFGGLTPIAVTMLMSVS--PMAPAWYVLALSLV 409
Cdd:cd17366 288 I--FIGLLVLGLLLSCYTATMAstlpalFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATgnPLMPAYYLMVAAVV 365
|
410
....*....|
gi 507080879 410 GLGLGIWLRQ 419
Cdd:cd17366 366 GLVAVLFLTE 375
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
14-419 |
8.42e-62 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 208.03 E-value: 8.42e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 14 KTLTLAALGGALEFYDFIIFVFFAAVVGELFFPADIPEwLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSI 93
Cdd:PRK10642 16 KAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPS-VQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 94 LLMAIPTLAIGLLPTYASMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVA 173
Cdd:PRK10642 95 VIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 174 TLVNTSLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIF------LEMQQRKALA--QELPVKSVVSKHKKA--- 242
Cdd:PRK10642 175 VLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFqqhvdkLEQGDREGLQdgPKVSFKEIATKHWRSllt 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 243 ---VVIS------MLLTWLlsagivvvilmsPVWLQKQYGFApaltlQANSVATIM-LCVGCLLA----GFIVDRVGASK 308
Cdd:PRK10642 255 cigLVIAtnvtyyMLLTYM------------PSYLSHNLHYS-----EDHGVLIIIaIMIGMLFVqpvmGLLSDRFGRRP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 309 TFIVGSLLLACSSWFFYHLTGSHPQHLfLLYGLVGLCVGV---VGAVPYVMVRAFPAEVRFTGISFSYNVSYAIfGGLTP 385
Cdd:PRK10642 318 FVILGSVALFVLAIPAFILINSNVIGL-IFAGLLMLAVILncfTGVMASTLPAMFPTHIRYSALAAAFNISVLV-AGLTP 395
|
410 420 430
....*....|....*....|....*....|....*.
gi 507080879 386 IAVTMLMSVSP--MAPAWYVLALSLVGLGLGIWLRQ 419
Cdd:PRK10642 396 TLAAWLVESTQnlMMPAYYLMVVAVIGLITGVTMKE 431
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
22-410 |
6.12e-47 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 167.22 E-value: 6.12e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 22 GGALEFYDFIIFVFFAAVV-GELFFPADIPEwLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPT 100
Cdd:PRK09952 30 GAVVDWYDFLLYGITAALVfNREFFPQVSPA-MGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMGIAT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 101 LAIGLLPTYASMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSL 180
Cdd:PRK09952 109 ALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMT 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 181 TQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKALAQ-ELPVKSVVSKHKKA--VVISMLLTWLLSAGI 257
Cdd:PRK09952 189 TDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKkRIPVIEALLRHPGAflKIIALRLCELLTMYI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 258 VVVILMSpvWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSW-FFYHL-TGSHPQHL 335
Cdd:PRK09952 269 VTAFALN--YSTQNLGLPRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRRVYITGALIGTLSAFpFFMALeAQSIFWIV 346
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507080879 336 FLLYGLVGLCVGVVGAVPYVM-VRAFPAEVRFTGISFSYNVSYAIFGGLTPIAVTMLMSVSpmAPAWYVLALSLVG 410
Cdd:PRK09952 347 FFSIMLANIAHDMVVCVQQPMfTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALVTYF--GGSWHSVAIYLLA 420
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
22-431 |
3.33e-46 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 165.12 E-value: 3.33e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 22 GGALEFYDFIIFVFFAAVVGELFFPADiPEWLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTL 101
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAIAKTFFPAG-NEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 102 AIGLLPTYASMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSLT 181
Cdd:PRK15075 102 LIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQWLS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 182 QQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKALAQelpVKSVVSKHKKAVVISMLLTWLLSAGIVVVI 261
Cdd:PRK15075 182 PAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMRE---IFRSLAANWRIVLAGMLMVAMTTVSFYLIT 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 262 LMSPVwlqkqYGFApALTLQANSVATIMLCVGCL------LAGFIVDRVGASKTFIVGSLLLACSSWFFYHLTGSHPQHL 335
Cdd:PRK15075 259 VYTPT-----FGKT-VLHLSAADSLLVTLCVGVSnfiwlpIGGALSDRIGRRPVLIAFTVLAILTAYPALSWLVAAPSFA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 336 FLLYGLVGLCV-------GVVGAVPYVMvrafPAEVRFTGISFSYNVSYAIFGGLTPIAVTMLMSVS--PMAPAWYVLAL 406
Cdd:PRK15075 333 RMLAVELWLSFlygsyngAMVVALTEVM----PAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTgdKAAPGYWLSFA 408
|
410 420
....*....|....*....|....*
gi 507080879 407 SLVGLGLGIWLRQDLYHRDSSVQAE 431
Cdd:PRK15075 409 AVCGLIATLVLYRRRGARLQAAEAA 433
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
19-413 |
3.66e-38 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 143.41 E-value: 3.66e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 19 AALGGALEFYDFIIFVFFAAVVGELFFPADIPEwLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAI 98
Cdd:PRK10406 27 ASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTT-TQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMMCF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 99 PTLAIGLLPTYASMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNT 178
Cdd:PRK10406 106 GSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQQ 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 179 SLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETpiflEMQQRKALAQELPVKSvVSKHKKAVVISMLLTwllsAGIV 258
Cdd:PRK10406 186 TLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET----SQQETRALKEAGSLKG-LWRNRRAFIMVLGFT----AAGS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 259 VVILMSPVWLQKQYGFAPALTLQ-ANSVATIMLCVGCLLA---GFIVDRVG-ASKTFIVGSLLLACSSWFFYHLTG-SHP 332
Cdd:PRK10406 257 LCFYTFTTYMQKYLVNTAGMHANvASGIMTAALFVFMLIQpliGALSDKIGrRTSMLCFGSLAALFTVPILSALQNvSSP 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 333 QHLFLLYGLVGLCVGVVGAVPYVM-VRAFPAEVRFTGISFSYNVSYAIFGGLTPIAVTMLMSV-SPMAPAWYVLALS--- 407
Cdd:PRK10406 337 YAAFGLVMCALLIVSFYTSISGILkAEMFPAQVRALGVGLSYAVANALFGGSAEYVALSLKSIgMETAFFWYVTLMAvva 416
|
....*..
gi 507080879 408 -LVGLGL 413
Cdd:PRK10406 417 fLVSLML 423
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
18-415 |
2.21e-32 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 126.65 E-value: 2.21e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 18 LAALGGALEFYDFIIFVFFAavvgelffPADIPEW-LRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLM 96
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVL--------PALIAEFgLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLF 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 97 AIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLgsvvATLV 176
Cdd:cd17371 75 AVFTLLCGFAQNYWQLLIL--------RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLL----ATLL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 177 NTSLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKALAQELPVKSVV--SKHKKAVVISMLLTWLLS 254
Cdd:cd17371 143 AALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELfsPPLLRTTLLASLLATGAL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 255 AGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACS--SWFFYHLTgshP 332
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISilLYFFLPLS---P 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 333 QHLFLLYGLVGLCV-GVVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIfGGLTPIAVTMLMSVSPMAPAWYVLALSLVGL 411
Cdd:cd17371 300 TLILILGFPLGFFAsGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFLATSGSLGTAIAVFAAVYYIA 378
|
....
gi 507080879 412 GLGI 415
Cdd:cd17371 379 GLVL 382
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-418 |
1.58e-30 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 121.53 E-value: 1.58e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 13 YKTLTLAALGGALEFYDFIIFVFFAAVVGELFfpadipeWLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLS 92
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-------GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 93 ILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVV 172
Cdd:COG2223 77 LLLLGIGLLLLALAVSYWLLLLL--------GLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 173 ATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYL-RRWLQETPIFLEMQQRKALAQELpvksVVSKHKKAVVISMLLTw 251
Cdd:COG2223 149 APLL--------IAAFGWRNAFLILGILLLVVAVLaWLFLRDPPAGAAAAAKASLRDQL----EALRDPRFWLLSLLYF- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 252 LLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFYHLTGSH 331
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 332 PQHLFLLYGLVGLCVGVVGAVPYVMVRAFPAEVRFTGISFSYnVSYAIFGGLTPIAVTMLMSV--SPMAPAWYVLALSLV 409
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVG-AAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALV 374
|
....*....
gi 507080879 410 GLGLGIWLR 418
Cdd:COG2223 375 ALVLTLLLY 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-417 |
1.96e-27 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 112.27 E-value: 1.96e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 5 TRPLNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVGELFFpadipewLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVG 84
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLG-------LSAAQLGLLASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 85 RKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTV 164
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGFATSFWQLLLL--------RFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 165 GILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYLRRWLqetpiflemqqrkalaqelpvksvvskhkkavv 244
Cdd:COG2271 146 GGALAPPLLGWL--------LAAFGWRAAFLILGLPGLLLALLRFWL--------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 245 isMLLTWLLSAGIVVVILM-SPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGAS-KTFIVGSLLLACSSW 322
Cdd:COG2271 185 --LALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALAL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 323 FFYHLTGSHPQhLFLLYGLVGLCVGVVGAVPYVMVR-AFPAEVRFTGISFsYNVSYAIFGGLTPIAVTMLMSVSPMAPAW 401
Cdd:COG2271 263 LLLALLPSPAL-AIALLFLAGFGLGGAFGLLWALAAeLFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
410
....*....|....*.
gi 507080879 402 YVLALSLVGLGLGIWL 417
Cdd:COG2271 341 LLLAALALLAALLALL 356
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-318 |
1.48e-25 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 105.66 E-value: 1.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 1 MSQHTRPLNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVGELFFPAdipewLRQVQTfgIFAAGYLARPLGGIIMAHFG 80
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGAS-----SAQLGW--IVSAYLLGRAIGLLLFGRLG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 81 DLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTA 160
Cdd:COG0477 74 DRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAA--------RALQGIGAGGLMPGALALIAELFPARERGRALGLWGA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 161 GLTVGILLGSVVATLVNTSLtqqavhdyGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKALAQELPVKSVVSkhk 240
Cdd:COG0477 146 AIGLGLALGPLLGGLLVAAL--------GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALA--- 214
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507080879 241 KAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLA 318
Cdd:COG0477 215 LLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
61-378 |
9.15e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 104.29 E-value: 9.15e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWV 140
Cdd:COG2814 50 VVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAA--------RFLQGLGAGALFPAALA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYL-RRWLQETPIFLE 219
Cdd:COG2814 122 LIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL--------ADLFGWRWVFLVNAVLALLALLLlLRLLPESRPAAR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 220 MQQRKALAQELpvksvvskHKKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGF 299
Cdd:COG2814 194 ARLRGSLRELL--------RRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 300 IVDRVGASKTFIVGSLLLACSSWFFyhLTGSHPQHLFLLYGLVGLCVGVVGAVPYVMV-RAFPAEVRFTGISFSYNVSYA 378
Cdd:COG2814 266 LADRFGRRRLLLIGLLLLALGLLLL--ALAGSLWLLLLALFLLGFGFGLLFPLLQALVaELAPPEARGRASGLYNSAFFL 343
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
3-375 |
3.57e-24 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 103.59 E-value: 3.57e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 3 QHTRPLNRQDYKTLTLAALGGALEFYDFIIFVFFAavvgelffPADIPEWLRQVQTFG-IFAAGYLARPLGGIIMAHFGD 81
Cdd:TIGR00895 6 IRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAA--------PAISAEWGLDPVQLGfLFSAGLIGMAFGALFFGPLAD 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 82 LVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAG 161
Cdd:TIGR00895 78 RIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL--------RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 162 LTVGILLGSVVATLvntsltqqAVHDYGWRIPFLLGGVFGLV-AMYLRRWLQETPIFLEMQQRKALAQ------------ 228
Cdd:TIGR00895 150 YPIGAAVGGFLAGW--------LIPVFGWRSLFYVGGIAPLLlLLLLMRFLPESIDFLVSKRPETVRRivnaiapqmqae 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 229 ---ELPVKSVVSKHKKAVV---------ISMLLTWLLSAGIVVVILMSPVW---LQKQYGFAPALTLQANSVATIMLCVG 293
Cdd:TIGR00895 222 aqsALPEQKSTQGTKRSVFkalfqgktaRITVLLWLLYFMLLVGVYFLTNWlpkLMVELGFSLSLAATGGALFNFGGVIG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 294 CLLAGFIVDRVGASKTFIVgsLLLACSSWFFYHLTGSHPQHLFLLYGLVGLCV-GVVGAVPYVMVRAFPAEVRFTGISFS 372
Cdd:TIGR00895 302 SIIFGWLADRLGPRVTALL--LLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVnGGQSGLYALMALFYPTAIRATGVGWA 379
|
...
gi 507080879 373 YNV 375
Cdd:TIGR00895 380 IGI 382
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
6-431 |
8.48e-24 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 103.24 E-value: 8.48e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 6 RPLNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVGELFfpadipeWLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGR 85
Cdd:PRK03893 12 RHLNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEF-------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 86 KKMFTLSILLMAIPTLAIGLLPTYASMGIlaplllllMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVG 165
Cdd:PRK03893 85 RLAMVISIVLFSVGTLACGFAPGYWTLFI--------ARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 166 ILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKAlaqelPVKSVVSK--HKKAV 243
Cdd:PRK03893 157 AVVAAQVYSLV--------VPVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKHAGKA-----PVRTMVDIlyRGEHR 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 244 VISMLLT-------------------------------------------WLLSAGIVVVILMS-----------PVWLQ 269
Cdd:PRK03893 224 IINILLTlaaaaalwfcfagnlqnaaivavlgllcaaifisfmvqssgkrWPTGVMLMVVVLFAflyswpiqallPTYLK 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 270 KQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFYHLTGSHPQHL-FLLYGLVGLCVGV 348
Cdd:PRK03893 304 TDLGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGANVWVLgLLLFFQQMLGQGI 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 349 VGAVPYVMVRAFPAEVRFTGISFSYNVSyAIFGGLTPIAVTMLMSVSPMAPAWYVLALSL-----VGLGLGIWLRQDLYH 423
Cdd:PRK03893 384 SGLLPKLIGGYFDTEQRAAGLGFTYNVG-ALGGALAPILGALIAQRLDLGTALASLSFSLtfvviLLIGLDMPSRVQRWL 462
|
....*...
gi 507080879 424 RDSSVQAE 431
Cdd:PRK03893 463 RPEALRTH 470
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
61-418 |
6.59e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.49 E-value: 6.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWV 140
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA--------RFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSltqqavhdYGWRIPFLLGGVFGLVAMYLRRWLQETPIfLEM 220
Cdd:cd17325 108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRAPFLVCAALALLALVLALLLLPEPR-PPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 221 QQRKALAQELPVKSVVSKHKKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFI 300
Cdd:cd17325 179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 301 VDRVGASKTFIVGSLLLACSSWFFYHLTGshPQHLFLLYGLVGLCVGVVGAVPYVMV-RAFPAEVRFTGISFsYNVSYAI 379
Cdd:cd17325 259 SDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLGLGLVFPATLALLaDIVPPEGRGTAMGL-FNTAFSL 335
|
330 340 350
....*....|....*....|....*....|....*....
gi 507080879 380 FGGLTPIAVTMLMSVSPMAPAWYVLALSLVGLGLGIWLR 418
Cdd:cd17325 336 GMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
61-385 |
1.26e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 83.62 E-value: 1.26e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWV 140
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVL--------RVLQGLGAGALFPAALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSltqqavhdYGWRIPFLLGGVFGLVAMYLrrWLQETPIFLEM 220
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--------FGWRAAFLILAILSLLAAVL--LLLPRPPPESK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 221 QQRKALAQELPVKSVVSKHKKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFI 300
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 301 VDRVGASKTFIVGSLLLACSSWFFYHLTGSHPQHLFLL-YGLVGLCVGVV-GAVPYVMVRAFPAEVRFTGISFsYNVSYA 378
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLaLLLLGFGFGLVfPALNALVSDLAPKEERGTASGL-YNTAGS 337
|
....*..
gi 507080879 379 IFGGLTP 385
Cdd:pfam07690 338 LGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
57-417 |
1.27e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 83.75 E-value: 1.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 57 QTFGIFAAGYLarpLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVP 136
Cdd:cd17324 38 LLVSAYALGYA---LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA--------RALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 137 GAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSLtqqavhdyGWRIPFLLGGVFGLVAMY-LRRWLQETP 215
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL--------GWRAAFLAIAVLALLAALlLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 216 IFLEMQQRKALAQELPVKSvvskhkKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCL 295
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRN------PRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 296 LAGFIVDRVGASKTFIVGSLLLACSSWffyhLTGSHPQHLFLLYGLVGLCVGVVGAVPYVMVRAFPAEVRFTGISFS-YN 374
Cdd:cd17324 253 LAGRLADRGGRRALLIALLLLAAALLL----LTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSlYL 328
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 507080879 375 VSYAIFGGLTPIAVTMLMSVSPMAPAWYVLALsLVGLGLGIWL 417
Cdd:cd17324 329 AAYNLGGALGAALGGLVLDHGGWAGVGWVGAA-LLLLALLLAL 370
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
17-405 |
2.23e-16 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 80.78 E-value: 2.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 17 TLAALGGALEFYDFIIFVFFAAVVGEL-FFPADIPEW---LRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLS 92
Cdd:pfam00083 3 LVAALGGFLFGYDTGVIGAFLTLIDFFkNFGLSKSVSslaALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 93 ILLMAIPTLAIGLLPTYASMGILApllllLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVV 172
Cdd:pfam00083 83 NVLFVIGAVLQGAAKGKWSVYQLI-----VGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 173 ATLVNTSltqqaVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKALAQE----------------------- 229
Cdd:pfam00083 158 GLGLNKT-----SNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREvlaklrgvpdvdreldeikdsle 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 230 ----------LPVKSVVSKHKKAVVISMLLTWLLSAGIVVVILMSPVwLQKQYGFAPalTLQANSVATIMLCVGCLLAGF 299
Cdd:pfam00083 233 agqeaekaswKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTT-IFENLGLSD--SFLVTIIVGVVNFVFTFIAIF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 300 IVDRVGASKTFIVGSLLLACSSWF----FYHLTGSHPQHLFLLygLVGLCVGV------VGAVPYVMV-RAFPAEVRFTG 368
Cdd:pfam00083 310 LVDRFGRRPLLLLGAAGMAICFVIlgivALLGVSKSDWAGIVA--IVFIALFIaffamgWGPVPWVIVsELFPLSVRSKA 387
|
410 420 430
....*....|....*....|....*....|....*..
gi 507080879 369 ISFSYNVSYaIFGGLTPIAVTMLMSVSPMAPAWYVLA 405
Cdd:pfam00083 388 MALATAANW-LANFLIGFLFPIITDAIGLGYTFFIFA 423
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
74-415 |
8.42e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 78.37 E-value: 8.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 74 IIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMgILAplllllmRILQGAAIGGEVPGAWVFVAEHVPERRIGI 153
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAA-------RALQGIGAAAIMPASLALIAATFPGERRGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 154 ACGTLTAGLTVGILLGSVVATLVNTSLtqqavhdyGWRIPFLLGGVFGLVAMYLRRwlqetpiflemqqrkalaqelpvk 233
Cdd:cd17321 121 ALGLWGAVVGIGAALGPLLGGLLLELF--------GWRWIFLINVPIGLVALLLAR------------------------ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 234 svvskhkkAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVG 313
Cdd:cd17321 169 --------TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 314 SLLLACSSWFFYHLTGSHPQHLFLL-YGLVGLCVG-VVGAVPYVMVRAFPAE-----------VRFTGISFSYNVSYAIF 380
Cdd:cd17321 241 LLLTAVGLLLLALLGADSSVWLLLPgLVLLGLGLGlFATPLTNAALSSVPKEkagaasgilntARQLGGALGVALLGALL 320
|
330 340 350
....*....|....*....|....*....|....*..
gi 507080879 381 GGLTP--IAVTMLMSVSPMAPAWYVLALSLVGLGLGI 415
Cdd:cd17321 321 TAGLSanLGDSGVAALLSAAAAAFAAGFHLAFLVAAA 357
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
8-413 |
1.38e-15 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 78.43 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 8 LNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVgelffPADIPewLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKK 87
Cdd:PRK12307 12 ITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLI-----KADLG--LTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 88 MFTLSILLMAIPTlaiGLLPTYASMGILApllllLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGil 167
Cdd:PRK12307 85 LMMWSIVAYSVGT---GLSGLASGVIMLT-----LSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIG-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 168 lgsvvaTLVNTSLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKALAQELPVKSVVSKHKKAVVISM 247
Cdd:PRK12307 155 ------NIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 248 LLTWLLSAGIVVVILMSPVW----LQKQY----GFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVG---SLL 316
Cdd:PRK12307 229 QFPLTLCVFIVLFSIFGANWpifgLLPTYlageGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGllmSFL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 317 LACSSWFF----YHLTGShpqhlfLLYGLVGLCVGVVGAVPYVMVRAFPAEVRFTGISFSYNVSyAIFGGLTPIAVTML- 391
Cdd:PRK12307 309 FIFPLFRIpqdnYLLLGA------CLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLA-ATSGTFNSMAATWLg 381
|
410 420
....*....|....*....|....*...
gi 507080879 392 ------MSVSPMAPAWYVLALSLVGLGL 413
Cdd:PRK12307 382 itmglgAALTFIVAFWTATILLIIGLSI 409
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
61-415 |
3.89e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 76.70 E-value: 3.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWV 140
Cdd:cd06174 36 LFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG--------RFLLGLGSGLIDPAVLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSLTqqavhdYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEM 220
Cdd:cd06174 108 LIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG------FGWRAVFLIAAALALLAAILLLLVVPDPPESAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 221 QQRKALAQELPVKSVVSKHK-KAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGF 299
Cdd:cd06174 182 AKNEEASSKSVLKLLKRVLKnPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 300 IVDRVGASKTFIVGSLLLACSSWFFYHLTGSHPQhLFLLYGLVGLCVGVVGAVPYVMV-RAFPAEVRFTGISFsYNVSYA 378
Cdd:cd06174 262 LSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLL-LLLLLLLLGFGLGGLLPLSFALIaELFPPEIRGTAFGL-LNTFGF 339
|
330 340 350
....*....|....*....|....*....|....*..
gi 507080879 379 IFGGLTPIAVTMLMSVSPMAPAWYVLALSLVGLGLGI 415
Cdd:cd06174 340 LGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
45-411 |
4.60e-14 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 73.00 E-value: 4.60e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 45 FPADIPEWLRQVQTFG-IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllm 123
Cdd:cd17365 22 APALAQDWGLSPAQLGpVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL-------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 124 RILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLV 203
Cdd:cd17365 94 RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAAL--------IPAFGWRSVFLLGGVPPLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 204 AMYLrrwlqetpiflemqqrkalaqelpvksvvskhkkavVISMLLTWLLSAGIVVVILMSPVWLQKQYGfAPALTLQAN 283
Cdd:cd17365 166 LLPL------------------------------------LRGTLLLWVTFFMGLLLVYLLNSWLPKLMV-EAGYSLSQA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 284 SVATIML----CVGCLLAGFIVDRVGASKTFIVGSLLLAcsswFFYHLTGSHPQHLFLLYGLV---GLCV-GVVGAVPYV 355
Cdd:cd17365 209 LTITLLLniggVIGSLLLGWLADRFGPKRVLALFFALGA----VSLALLGVSPASLVLLYVLVflaGACVnGAQVGLYAL 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 507080879 356 MVRAFPAEVRFTGISFSYNVSY--AIFGgltPIAVTMLMSvSPMAPAWYVLALSLVGL 411
Cdd:cd17365 285 AARFYPTEVRATGVGWALGVGRlgAILG---PLLGGLLLA-AGLGPESVFLALAIPAA 338
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
59-418 |
3.79e-12 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 67.21 E-value: 3.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 59 FGIFAAGYLarpLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGA 138
Cdd:cd17319 44 ASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVL--------RFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 139 WVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLvntsltqqAVHDYGWRIPFLLGGVFGLVA-----MYLRRWLQE 213
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGW--------LLLLFGWRWAFIIEGLLGLLLavlwwFYLRQVWGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 214 TPIFLEMQqrkalaqelpvksvvskhkkaVVISMLLTWLlsagivvvilmsPVWLQKQYGFAPALTLQANSVATIMLCVG 293
Cdd:cd17319 185 ALGYFGIN---------------------YALYGLLTWL------------PTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 294 CLLAGFIVDRV--GASKTFIVGSLLLACSSWFFYHLTGSHPQHLFLLYGLVGLCVGVVGAVPYVMVRAFPAEVRFTGISF 371
Cdd:cd17319 232 MILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 507080879 372 sYNVSYAIFGGLTPIAVTMLMSVS-PMAPAWYVLALSLVgLGLGIWLR 418
Cdd:cd17319 312 -INSGGNLGGFVAPLLIGYLVDATgSYTAAFLFLAAVAL-LAALLVLL 357
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
61-369 |
5.91e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 66.91 E-value: 5.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMgilaplllLLMRILQGAAIGGEVPGAWV 140
Cdd:PRK11551 55 AFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSL--------LVARLLTGVGLGGALPNLIA 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLvntsltqqAVHDYGWRIPFLLGGVFGLVAM-YLRRWLQETPIFLe 219
Cdd:PRK11551 127 LTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVL--------AAGDAAWRHIFYVGGVGPLLLVpLLMRWLPESRAFA- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 220 mQQRKALAQELPVKSVVSKHKKAVVISMLLTWLLSAGIVVVILMS--PVWLQKQyGFAPAltlQANSVaTIML----CVG 293
Cdd:PRK11551 198 -QAAGAGKQRAPVLRALFGEGRATATLLLWISYFFTLIVLYFLLNwlPSLLVGQ-GLSRS---QAGLV-QIAFniggALG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 294 CLLAGFIVDRVGASKTFI---VGSLL-LACsswffyhLTGSHPQHLFLLYGLV-GLCVGVVGAVPYVMVRAF-PAEVRFT 367
Cdd:PRK11551 272 SLLIGALMDRLRPRRVVLliyAGILAsLAA-------LAAAPSFAGMLLAGFAaGLFVVGGQSVLYALAPLFyPTQVRGT 344
|
..
gi 507080879 368 GI 369
Cdd:PRK11551 345 GV 346
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
71-372 |
6.54e-12 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 66.82 E-value: 6.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 71 LGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGIlaplllllMRILQGAAIGGEVPGAWVFVAEHVPERR 150
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFII--------ARIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 151 IGIACGTLTAGLTVGILLGSVVATLVNTSLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLemqqrkalaqel 230
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWL------------ 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 231 pvksvVSKHKKAVVISMLLTWLLSA-GIVVVILMSPVWLQKQyGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKT 309
Cdd:cd17359 191 -----VSKGKPILIIGIGLAIFQQFvGINVIFYYGPEIFQNA-GFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPL 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507080879 310 FIVGSLLLACS----SWFFYHLTGSHPQH---LFLLYGLVGLCVGVVGAVPYVMV-RAFPAEVRFTGISFS 372
Cdd:cd17359 265 LLIGSIGMAISllliGTAFYFAPGSQASGivaLVLILLFVAFFAMSWGPVTWVLLsEIFPNRIRGLAMGIA 335
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
75-395 |
1.17e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 65.68 E-value: 1.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 75 IMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAiGGEVPGAWVFVAEHVPERRIGIA 154
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG--------RALQGIG-GAVFPLAFALVREEFPPERVPVA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 155 CGTLTAGLTVGILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYLrrwlqeTPIFlemqQRKALAQelpvks 234
Cdd:cd17504 121 QGILSATFGIGAGIGLPLGGWI--------VQHLGWRWIFWTAAPVAVLLAAL------VPLI----DLRLLRR------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 235 vvskhkKAVVISMLLTWLLSAGIVVVILMSPVWLQ--KQYGF-----APALTLQANSVATImlcVGCLLAGFIVDRVGAS 307
Cdd:cd17504 177 ------RNVLLANITALLAGFGMFMVFQLLPQLLQlpTPTGFglgitEAGLLLLPGALVML---IAGPLAGRLIARVGPR 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 308 KTFIVGSLLLACsSWFFYHLTGSHPQHLFLLYGLVGLCVG-VVGAVPYVMVRAFPAEvrFTGISFSYN-VSYAIFGGLTP 385
Cdd:cd17504 248 RVLLIGLVISAV-GLLLLALLHSSLWALVVALLLIGIGLGlAFASLPNIVVESVPPD--RTGIATGMNtVLRTIGSAIGP 324
|
330
....*....|
gi 507080879 386 IAVTMLMSVS 395
Cdd:cd17504 325 AIAGAILTTY 334
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
5-215 |
3.44e-10 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 61.67 E-value: 3.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 5 TRPLNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVGELFFPADIPewLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVG 84
Cdd:TIGR00887 7 TAPFGWQHFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGP--LPSSVSAAVNGSASIGTLAGQLFFGWLADKLG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 85 RKKMFTLSILLMAIPTLAIGLLPTYASMGILAplLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTV 164
Cdd:TIGR00887 85 RKRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGAMMAAVFAMQGF 162
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507080879 165 GILLGSVVATLVN----------------TSLTQQAVhDYGWRIPFLLGGVFGLVAMYLRRWLQETP 215
Cdd:TIGR00887 163 GILAGAIVALIVLagfkhsleaaadeascTGSCVPAV-DYMWRILIGFGAVPALLALYFRLTIPETP 228
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
79-349 |
4.52e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 61.05 E-value: 4.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 79 FGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMgILAplllllmRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTL 158
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASL-IIF-------RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 159 TAGLTVGILLGSVVATLVNTSltqqavhdYGWRIPFLLGGVFGLVAMYLrrwlqeTPIflemqqrkalaqeLPVKsvVSK 238
Cdd:cd17503 126 GLVILLAPAIGPTLGGWLTDN--------LSWRWIFYINLPIGILALLL------APL-------------LDLR--LFK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 239 HkKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLA 318
Cdd:cd17503 177 D-RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLA 255
|
250 260 270
....*....|....*....|....*....|..
gi 507080879 319 CSSWFFYHLT-GSHPQHLFLLYGLVGLCVGVV 349
Cdd:cd17503 256 LGTLLLAFLTpDTSLWLIILPLFIRGLGMGLV 287
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
58-376 |
1.78e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 59.20 E-value: 1.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 58 TFGI-FAAGYLARPLGGIimahFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAaIGGEVP 136
Cdd:cd17391 41 AFSStFLVSAIFSPIWGR----LADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLIL--------RLLQGV-FSGYVP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 137 GAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSltqqavhdYGWRIPFLLGGVFGLVAMYLrrwlqetPI 216
Cdd:cd17391 108 NATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADL--------FGIRNVFFITGGLLFLAFLL-------TL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 217 FL--EMQQRKALAQELPVKSVVS--KHKKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCV 292
Cdd:cd17391 173 FFvkEDFKPVEKKKMVSTKEVWNsvPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVS 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 293 GCLLAGF---IVDRVGASKTFIVGslLLACSSWFFYHLTGSHPQHLFLLYGLVGLCVGV-VGAVPYVMVRAFPAEVrfTG 368
Cdd:cd17391 253 SLLSAPRlgkLGDRIGHHRILLGA--LLASALLYIPQAFVQTPWQLGILRFLLGLATGGlLPAINSLLAKITPKEV--AG 328
|
....*...
gi 507080879 369 ISFSYNVS 376
Cdd:cd17391 329 RIFGYNQS 336
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
61-413 |
2.54e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 2.54e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILAplllllmrILQGAAIGGEVPGAWV 140
Cdd:COG0738 48 LLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL--------FLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPE---RRIGIACGTLTAGLTVGILLGSVVATLVntsltqqavHDYGWRIPFLLGGVFGLVAMYLRRWLQetpif 217
Cdd:COG0738 120 YVAALGPEtaaSRLNLLHAFFSLGALLGPLLGGLLILLG---------LSLSWHLPYLILAVLLLLLALLFLRSK----- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 218 LEMQQRKALAQELPVKSVVSKHKKAVVISMLLTWLLSAGI-VVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLL 296
Cdd:COG0738 186 LPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAeGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 297 AGFIVDRVGASKTFIVGSLLLACSSWFFyhLTGSHPQHLFLLYGLVGLCVGVVgaVPYVMVRAFPAEVRFTGISFSYNVS 376
Cdd:COG0738 266 GGFLLKRFGPVRLLRLSALLAAVGLLLA--LLAPGPWLALIGLALVGLGLSLM--FPTIFSLALDGLGKRTAAAVSAVLI 341
|
330 340 350
....*....|....*....|....*....|....*...
gi 507080879 377 YAIFGGLT-PIAVTMLMSVSPMAPAWYVLALSLVGLGL 413
Cdd:COG0738 342 MGIVGGAIgPPLIGFLADAFGLRAAFLVPLVCYLLILL 379
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
72-211 |
2.76e-09 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 58.44 E-value: 2.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 72 GGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILAplLLLLMRILQGAAIGGEVPGAWVFVAEHVPERRI 151
Cdd:cd17364 55 GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRR 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 507080879 152 GIACGTLTAGLTVGILLGSVVATLV----NTSLTQQAVH--DYGWRIPFLLGGVFGLVAMYLRRWL 211
Cdd:cd17364 133 GALIAAVFAMQGFGILAGAIVTLILsaifEHPLPAGTYHhaDLVWRIVLGLGAIPALSVLYFRKHL 198
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
57-417 |
7.43e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 57.20 E-value: 7.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 57 QTFGIFAAGYLarpLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVP 136
Cdd:cd17320 38 LTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIA--------RFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 137 GAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSLtqqavhdyGWRIPFLLGGVFG-LVAMYLRRWLQETp 215
Cdd:cd17320 107 VARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF--------GWRAIFVFLALLGlLLLLLVLLFLPET- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 216 ifLEMQQRKALAQELPVKSVVSKHKKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCL 295
Cdd:cd17320 178 --LPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 296 LAGFIVDRVGASKTFIVGSLLLACSS--WFFYHLTGSHPQHLFLLY-GLVGLCVGVVGAVPYVMVRAFPAEVRFTGISFs 372
Cdd:cd17320 256 LNGRLVRRFGPRRLLRLGLLLLLAAAlvLLLAALLGGLSLWPLVAPlFLIFFGFGLIFPNATSLALEPFPHVAGTASAL- 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 507080879 373 YNVSYAIFGGLTPIAVTMLMSVSPMAPAWYVLALSLVGLGLGIWL 417
Cdd:cd17320 335 LGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
159-417 |
1.43e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.45 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 159 TAGLTVGILLGSVVATLVNTSLTQQAVHdyGWRIPFLLGGVFGLVAMYL-RRWLQETPIflEMQQRKALAQELpvkSVVS 237
Cdd:COG2211 153 FAFAGLGGLLASVLPPPLVAAFGGDAAL--GYRLTALIFAVLGLLAFLLtFFGTKERPV--PEEEKVSLKESL---KALL 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 238 KHK--KAVVISMLLTWLlsaGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSL 315
Cdd:COG2211 226 KNRpfLLLLLAYLLFFL---ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLL 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 316 LLACSSWFFYHLTGSHPQHLFLLYGLVGLCVGVVGAVPYVMV------RAFPAEVRFTGISFS-YNVSYAIFGGLTPIAV 388
Cdd:COG2211 303 LAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdyDEWKTGRRREGLYFGiFTFAIKLGQALAGALA 382
|
250 260
....*....|....*....|....*....
gi 507080879 389 TMLMSVSPMAPAWYVLALSLVGLGLGIWL 417
Cdd:COG2211 383 GLLLALFGYVAGAAQSPSALTGIRLLFFL 411
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
67-372 |
4.44e-08 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 54.89 E-value: 4.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 67 LARPLGGIIMAHFGDLVGRKKmftlSILLMAIPTLAIGLLPTYASMgilaPLLLLLMRILQGAAIGGEVPGAWVFVAEHV 146
Cdd:cd17358 52 LGALIGALLSGKLADRIGRKR----TLLISAIPCILGWLLIAFAKD----VWMLYLGRFLAGFGGGAASVVVPVYIAEIA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 147 PERRIGIACGTLTAGLTVGILLGSVVATLVNtsltqqavhdygWRIPFLLGGVFGLVAMYLRRWLQETPIFL-------- 218
Cdd:cd17358 124 PKNVRGALGSLNQLLVNIGILLGYVLGSFLP------------WRTLALIGAIPPVVFLILLFFIPESPRWLakkgreee 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 219 --------------------EMQQRKALAQELPVKSVVS-----KHKKAVVISMLLTWL--LSaGIVVVIL-MSPVwlqk 270
Cdd:cd17358 192 aekslqflrgkdadiskeaaEIQEELAELEKEAKESSFSdlfqrKYLKPLVIGLGLMLFqqLS-GINAVIFyASSI---- 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 271 qygFAPALTLQANSVATIMLCV----GCLLAGFIVDRVG------ASKTFI-VGSLLLACSSWFFYHLTGSHPQHLFLLY 339
Cdd:cd17358 267 ---FDEAGSGLDPNTATIIIGVvqvvGTLVATLLVDRLGrrplllVSAIGMgIGLLALGLYFYLQEHGALLSSVSWLPLV 343
|
330 340 350
....*....|....*....|....*....|....*..
gi 507080879 340 GLVGLCVGV---VGAVPYV-MVRAFPAEVRFTGISFS 372
Cdd:cd17358 344 GLVIYIISFsigLGPLPWViMSEIFPAKIKGLAGSLV 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-418 |
2.29e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.60 E-value: 2.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 62 FAAGYLARPLGGIIMahfgDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVF 141
Cdd:cd17489 41 TLAALLARPFAGRLL----DRFGRKRLLLIGLLIFALATLLYLLATSVALLLVL--------RLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 142 VAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPiflemQ 221
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFL--------YQHLGFAVLFIVAAVLALLALLLVFLVKDPP-----P 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 222 QRKALAQELPVKSVVSKHKKAVVISMLLTwLLSAGIVVVILMSPVWLQKQYGFAPALTLqanSVATIMLCVGCLLAGFIV 301
Cdd:cd17489 176 VAAEEAEAGTRAFRRLVEKKVLPPALILF-LASIAYGAISTFLPLYAAERGISNAGLFF---TVYAIALLLSRPFSGKLS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 302 DRVGASKTFIVGSLLLACSSWFFYHLTGshPQHLFLLYGLVGLCVG-VVGAVPYVMVRAFPAEVRFTGISfSYNVSYAIF 380
Cdd:cd17489 252 DRKGPKTVIIPGLLLLALGLLLLSFAGS--PWMLLLAAVLYGLGFGlLFPALQALAVDLVPPHRRGAANG-TFFIFFDLG 328
|
330 340 350
....*....|....*....|....*....|....*....
gi 507080879 381 GGLTPIAVTMLMSVSPMAPAWYVLA-LSLVGLGLGIWLR 418
Cdd:cd17489 329 IGLGGLLLGLVAELFGYRAMFLLAAvVVLLALVLYIFLL 367
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
71-419 |
1.89e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 1.89e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 71 LGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVFVAEH-VPER 149
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS--------RALLGIGVAGIMTLATALIGDYfEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 150 R---IGIACGTLTAGLTVGILLGSVVATLvntsltqqavhdyGWRIPFLLGG----VFGLVAMYLRrwlqetpiflEMQQ 222
Cdd:cd17473 122 RakmLGLQSAAMSLGGVVFLLLGGALAEI-------------GWRAPFLVYLlalpVLILVLLFLP----------EPAR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 223 RKALAQELPVKSVVSKHKKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVD 302
Cdd:cd17473 179 KSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 303 RVGASKTFIVGSLLLACsSWFFYHLTGSHPQhLFLLYGLVGLCVGVVgaVPYVMVRAF---PAEVRFTGISFsynVSYAI 379
Cdd:cd17473 259 RLGKRRLLAIGFALMAL-GFLLLALASGLWV-VLLGAILAGLGFGLL--LPTLNSWAMslvPPELRGRAMGI---VTSAF 331
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 507080879 380 FGG--LTPIAVTMLMSVSP-MAPAWYVLALSLVGLGLGIWLRQ 419
Cdd:cd17473 332 FLGqfLSPLVLGPLVNLTGgLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
58-357 |
2.29e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.48 E-value: 2.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 58 TFGIFAAgyLARPLGGIimahFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILAplllllmrILQGAAIGGEVPG 137
Cdd:cd17478 39 VFSITSS--LLQPLFGY----LADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--------ALAGIGSAAFHPE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 138 AWVFVAeHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSLTqqavhDYGWRIPFLLGGVFGLVAMYLRRWLQetpif 217
Cdd:cd17478 105 GARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFG-----GLGLLILLIIPGLAVALLLLRLRPLK----- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 218 leMQQRKALAQELPVKSVVSKHKKAVVISMLLTWLLSAGIVVVILMSPVWLqKQYGFAPALTLQANSVATIMLCVGCLLA 297
Cdd:cd17478 174 --KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYL-VQRGYSLVFAGLLLSLFLFAGAIGTLIG 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 298 GFIVDRVGASKTFIVGSLLLACSSWFFYHLTGshpQHLFLLYGLVGLCVGVVGAVPYVMV 357
Cdd:cd17478 251 GPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG---IWSYILLVLAGFLLFASFPVTVVLA 307
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
71-420 |
5.64e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.33 E-value: 5.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 71 LGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILAplllllmrILQGAAIGGEVPGAWVFVAEHVPeRR 150
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT--------ALIGAGIAVGNVLLPGLIKRWFP-DR 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 151 IGIACGTLTAGLTVGILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYLrrWLqetPIFLEMQQRKALAQEL 230
Cdd:COG2807 139 VGLMTGLYTAAMGLGAALAAGLTVPL--------AAALGWRGALAVWALLALLALLL--WL---PLLRRRPAAAAAAPAA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 231 PVKSVVSKHKKAVVISMLLTwLLSAGIVVVILMSPVWLQkQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTF 310
Cdd:COG2807 206 ASLRSLWRSPLAWLLTLFFG-LQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 311 IVGSLLLACSSWFFYHLTgshPQHLFLLY-GLVGLCVGvvGAVPYVMV----RAFPAEVRFTGISFSYNVSYAIfGGLTP 385
Cdd:COG2807 284 LLLLGLLGLAGLLGLLLA---PGSLPWLWaVLLGLGQG--GLFPLALTliglRARTPAEAAALSGMAQSVGYLL-AALGP 357
|
330 340 350
....*....|....*....|....*....|....*..
gi 507080879 386 IAVTMLMSV--SPMAPAWYVLALSLVGLGLGIWLRQD 420
Cdd:COG2807 358 LLVGALHDAtgSWTAALLLLAALAVLMLVAGLLAGRP 394
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
17-387 |
7.14e-06 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 48.10 E-value: 7.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 17 TLAALGGALEFYD-FIIFVFFAAVVGELFFPADIPEWLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILL 95
Cdd:TIGR00879 31 LIAAIGGLMFGYDtGVIGGALALPAFEFKFTSANSDSYSSSLWGLVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 96 MAIPTLAIGLLPTYASMGILApllllLMRILQGAAIGGEVPGAWVFVAEHVPE--RrigiacGTLTAGLTVGILLGSVVA 173
Cdd:TIGR00879 111 FVIGAILMGLAAFALSVEMLI-----VGRVLLGIGVGIASALVPMYLSEIAPKalR------GALTSLYQLAITFGILVA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 174 TLVNtSLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQR------------------KALAQELPVKSV 235
Cdd:TIGR00879 180 YGFG-SGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRveearkslarlrgtsgedKELLDELELIDI 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 236 VSKHKK-------------------AVVISMLLTWLLSA-GIVVVILMSPVWLQkQYGFAPALTLQANSVATIMLCVGCL 295
Cdd:TIGR00879 259 KRSIEKrsvqpswgslfsstrrirrRLFLGVVLQWFQQFtGINAIMYYSPTIFE-NAGVSTDHAFLVSIIVGAVNFAFTF 337
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 296 LAGFIVDRVGASKTFIVGSLLLACSSWFFYHLTGS--HPQHLFLLYG-LVGLCVGV------VGAVPYVMV-RAFPAEVR 365
Cdd:TIGR00879 338 VAIFLVDRFGRRPLLLIGAAGMAICLFVLGILGASfvTGSSKSSGNVaIVFILLFIaffamgWGPVPWVIVsEIFPLSLR 417
|
410 420
....*....|....*....|....*
gi 507080879 366 FTGISFS---YNVSYAIFGGLTPIA 387
Cdd:TIGR00879 418 PKGISIAvaaNWLANFIVGFLFPTM 442
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
144-395 |
2.24e-05 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 46.44 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 144 EHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSLtqqavhdyGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQR 223
Cdd:cd17486 118 EALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSL--------SWSAVYLIMAALMGPGILATLFAPEPPRTDPPANS 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 224 KALAQELPVKSVVSKHKKAVVISMLLTWLL--SAGIVVVILMSPVWLQKQYgFAPALTLQANSVATIMLCVGCLLAGFIV 301
Cdd:cd17486 190 LSETVVAFFAPFKDFFGQPGALLILAFILLykLGDAMLGAMATPFLLDLGF-TKTEIGAVYKTVGLIATIVGGLLGGFLM 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 302 DRVGASKTFIVGSLLLACSSWFFYHLTgSHPQHLFLLYGLVG---LCVGVVGA--VPYVMVRAFPaevRFTGisfsynVS 376
Cdd:cd17486 269 SRLGLKRSLWLFGILQALSNLGFIYLA-HAGPNLTLLVAAVAvenFGGGLGTTafVAYLMSLCNG---EFTA------TQ 338
|
250
....*....|....*....
gi 507080879 377 YAIFGGLTPIAVTMLMSVS 395
Cdd:cd17486 339 YALLSSLMALGRMVLGAPS 357
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
73-306 |
2.31e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 46.46 E-value: 2.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 73 GIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMgilaplllLLMRILQGAAIGGEVPGAWVFVAEHVPERRIG 152
Cdd:cd17328 51 SPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQL--------LLFRALVGIGEASYSPIAPTIIADLFPKEKRT 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 153 IACGTLTAGLTVGILLGSVVATLVntsltqqAVHDYGWRIPFLLGGVFGLVAMYLRRWlqetpiFLEMQQRKALAQELPV 232
Cdd:cd17328 123 RALGVFYFAIPLGSGLGYVVGGLV-------AQATGGWRWAFRVTGVLGVLLAILLLL------FVREPPRGAAEGGVMA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 233 KSVVSKH---------KKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPA----LTLQANSVATIMLCVGCLLAGF 299
Cdd:cd17328 190 KSTATSFladlkalakNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLssadVGLIFGAITCIAGVLGVLLGGI 269
|
....*..
gi 507080879 300 IVDRVGA 306
Cdd:cd17328 270 LADRLRR 276
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
74-418 |
2.85e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.02 E-value: 2.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 74 IIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVFVAEHVPERRIGI 153
Cdd:cd17474 52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG--------RALQGIGAAGLGPLALTLIGDLFEGGERAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 154 ACGTLTAGLTVGILLGSVVATLVNtsltqqavhDYGWRIPFLLGGVFGLVAMYLRRWLQETPiFLEMQQRKALAQELPVK 233
Cdd:cd17474 124 AMGLYEAALGLGIAVGPLLGGLLA---------AISWRYPFFLLAALIPVAFLAILFLLPEP-KEKAKSSSATKLRDLKK 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 234 SVvskHKKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVD-RVGASKTFIV 312
Cdd:cd17474 194 AL---RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 313 GSLLLACSswFFYHLTGSHPQHLFLLYGLVGLCVGVV-GAVPYVMVRAFPAEVRFTGISFsYNVSYAIFGGLTPIAVTML 391
Cdd:cd17474 271 GLLLYALS--LLLLGFVPSLALLLIAIVLFGLGLGLNlPLLTTLVTELAPEEERGTASSL-YNFVRFLGQAVGPLLFGLL 347
|
330 340
....*....|....*....|....*..
gi 507080879 392 MSVSPMAPAWYVLALSLVGLGLGIWLR 418
Cdd:cd17474 348 LEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
124-320 |
3.57e-05 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 45.70 E-value: 3.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 124 RILQGAAIGGEVPGAWVFVAEHVPERrigiACGTLTAGLTVGILLGSVVATLVNTSLtqQAVHDYGWRIPFLLGGVFGLV 203
Cdd:cd17361 111 RILLGFGVGFGNQAVPLYLSEMAPAK----LRGALNIGFQLAITIGILIANLINYGT--SKIKPNGWRLSLGLAAVPALI 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 204 AMYLRRWLQETPIFLEMqqrkalaqelpvksVVskhkkAVVISMLLTWllsAGIVVVILMSPVWLQkQYGFAPALTLQAN 283
Cdd:cd17361 185 LLLGSLFLPETPNSPQL--------------VI-----AILIPFFQQL---TGINVIMFYAPVLFQ-TLGFGSDASLISA 241
|
170 180 190
....*....|....*....|....*....|....*..
gi 507080879 284 SVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACS 320
Cdd:cd17361 242 VITGAVNVVSTLVSIYLVDRFGRRFLLLEGGVQMLAS 278
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
79-418 |
5.08e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 45.25 E-value: 5.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 79 FGDLVGRKKMFTLSILLMAIPTLAIGLLPtyaSMGILaplllLLMRILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTL 158
Cdd:cd17502 53 LSDLFGRKWVLLIAIVIFELGSLLCGLAP---NMTML-----IVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 159 TAGLTVGILLGSVVATLVNTSLTqqavhdygWRIPFLLGGVFGLVAMYLRRwlqetpiflemqqrkalaqelpvksvvsk 238
Cdd:cd17502 125 GAVFGIASVAGPLIGGAFTDHLS--------WRWCFYINLPIGGLALALLR----------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 239 hkkAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIV-GSLLL 317
Cdd:cd17502 168 ---TILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIViGTILM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 318 ACSSWFFYHLTGSHPQHLFLLY-GLVGLCVGVVGAVPYVMVR-AFPAEVRFTGISFSY---NVSYAIFGGLTPIavtmlm 392
Cdd:cd17502 245 SVGAGLLTTLTLDTSKWLLIGYlILLGLGLGIGFQQPLVAVQnAVPPADVGVATATNTffrSLGGTLGVAITDV------ 318
|
330 340
....*....|....*....|....*.
gi 507080879 393 svspmapAWYVLALSLVGLGLGIWLR 418
Cdd:cd17502 319 -------FLVALALAALAFLLSLFLP 337
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
61-417 |
1.28e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 43.72 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLarpLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWV 140
Cdd:cd17317 33 IFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVL--------RFLVGVTSAGIFTVGFV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTsltqqavhdygWRIPFLLGGVFGLVAMYLRRWlqetpiflem 220
Cdd:cd17317 102 LGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD-----------WRWLQLAISLPGLLFLLLLWW---------- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 221 qqrkalaqeLPVKSVVskhkkavvisMLLTWLLSAGIVVVILMSPVWLqkqyGFAPALTLQANSVATIMlcvGCLLAGFI 300
Cdd:cd17317 161 ---------LPRRTII----------VGLIWFVTSLVYYGLSLNSSNL----GGNLYLNFFLSGLVEIP---AYFLALLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 301 VDRVGaSKTFIVGSLLLACSSWFFYHLTGSHPQHLFLLYGLVG-LCVGVVGAVPYV-MVRAFPAEVRFTGISFSynVSYA 378
Cdd:cd17317 215 LDRLG-RRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGkFAISAAFSVIYLyTAELYPTVVRNTGVGLC--STVA 291
|
330 340 350
....*....|....*....|....*....|....*....
gi 507080879 379 IFGGLTPIAVTMLMSVSPMAPAWYVLALSLVGLGLGIWL 417
Cdd:cd17317 292 RVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLL 330
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
60-214 |
1.55e-04 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 41.48 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 60 GIFAAGYLARPL-GGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGIlaplllllMRILQGAAIGGEVPGA 138
Cdd:TIGR00880 1 GLLLAGYALGQLiYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII--------ARFLQGFGAAFALVAG 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507080879 139 WVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSltqqavhdYGWRIPFLLGGVFGLVAMYLR-RWLQET 214
Cdd:TIGR00880 73 AALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQF--------LGWRAPFLFLAILALAAFILLaFLLPET 141
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
71-248 |
1.57e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.85 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 71 LGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAAIGGEVPGAWVFVAEHVPeRR 150
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--------RLLVGMGIGGIWVQAVVLNTEFLP-KK 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 151 IGIACGTL-TAGLTVGILLGSVVATLVNtsltqqavhdyGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQRKALAQE 229
Cdd:TIGR00898 213 QRAIVGTLiQVFFSLGLVLLPLVAYFIP-----------DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALK 281
|
170
....*....|....*....
gi 507080879 230 LpVKSVVSKHKKAVVISML 248
Cdd:TIGR00898 282 I-LQRIAKINGKKLPAEVL 299
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
71-372 |
2.42e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.95 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 71 LGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMgilaplllLLMRILQGAAIGGEVPGAWVFVAEHVP-ER 149
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVL--------IVGRFLLGLGVGLASVLVPLYISEIAPaKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 150 RigiacGTLTAGLTVGILLGSVVATLVNTSLTQQAVHdyGWRIPFLLGGVFGLVAMYLRRWLQETpiflemqqrkalaqe 229
Cdd:cd17315 121 R-----GALGTLNQLMITFGILLAYLLGLALSLSPPG--WWRLMFALAAVPALLQLLLMFFLPES--------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 230 lpvksvvskhkKAVVISMLLTWLLS-AGIVVVILMSPVWLQKQYGFAPALTlqANSVATIMLCVGCLLAGFIVDRVGaSK 308
Cdd:cd17315 179 -----------RALLVGVGLQLLQQlTGINAVMYYAPTIFKSAGGGTASIL--ASIIVGVVNLLATLVAIRLVDKVG-RR 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507080879 309 TFIVGSLLLACSSWFFYHLTGSHPQHLFLLYGL--VGLCVGV------VGAVPYVMV-RAFPAEVRFTGISFS 372
Cdd:cd17315 245 PLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLalLGILLYIaafamgAGPVPWLLLsEIFPLRIRGKGMAIA 317
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
168-347 |
3.79e-04 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 42.45 E-value: 3.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 168 LGSVVATLVNTSLTQQA----VHDYGW--RIPFLLGGV-FGLVAMYLRRWLQETPIFLEMQQRKALAQELP-VKSVVS-- 237
Cdd:COG2270 155 LGGVLLLLINLALFLKPeafgLPDAGEavRISFLLTALwWLLFALPLFLFLPERPRPGPAPPRGAVRAGFReLRRTLRel 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 238 KHKKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLL 317
Cdd:COG2270 235 RRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIW 314
|
170 180 190
....*....|....*....|....*....|.
gi 507080879 318 ACSSWFFYhltGSHPQHLFLLYG-LVGLCVG 347
Cdd:COG2270 315 IVVCLAAY---FLTTALAFWILGlLIGLVMG 342
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
61-409 |
4.29e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 4.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMgilaplllLLMRILQGAAiGGEVPGAWV 140
Cdd:cd17330 39 LQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLL--------FLARFLDGLT-GGNVSVAQA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVA-MYLRRWLqetpifle 219
Cdd:cd17330 110 YIADITDEEERAKAFGIISAAFGLGFILGPALGGFL--------STPYGYALPFLVAAALALLNlVLVLFFL-------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 220 mqqrkalaqelpvksvvskhkKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGF 299
Cdd:cd17330 174 ---------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 300 IVDRVGASKTFIVGSLLLACSSWFFYhLTGSHPQHLFLLYGLVGLCVGVVGAVPYVMV-RAFPAEVRFTGISFSYNVSyA 378
Cdd:cd17330 233 RLAKRLGERKLLRLGLLLAIIGLLLL-PFASSVPLLVLAAAILAFGTGIVFPALSALLsKSVPSKEQGKAQGIIQSLQ-S 310
|
330 340 350
....*....|....*....|....*....|.
gi 507080879 379 IFGGLTPIAVTMLMSVSPMAPAWYVLALSLV 409
Cdd:cd17330 311 LARIIGPLLAGPLYSFLGPGVPFLLAAGLLL 341
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
61-418 |
4.42e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 4.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILAPLLLLLMRILQGAAIGgevPGAWV 140
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFG---PARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEM 220
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLL--------VALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 221 QQRKALAQELPVKSVVSKHKKAVVISMLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFI 300
Cdd:cd06173 188 ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 301 VDRVGASKTFIVGSLLLACSSWFFYhLTGSHPQhLFLLYGLVGLCVGVVGAVPYVMV-RAFPAEVRFTGISFsYNVSYAI 379
Cdd:cd06173 268 SKRRRRGRLLLIGALLLGLALLVLG-LSPSLWL-LLAALFLLGLAGGLFNVPLNTLLqLRVPDELRGRVFSV-YNALNSG 344
|
330 340 350
....*....|....*....|....*....|....*....
gi 507080879 380 FGGLTPIAVTMLMSVSPMAPAWYVLALSLVGLGLGIWLR 418
Cdd:cd06173 345 AMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
79-410 |
5.29e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 5.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 79 FGDLVGRKKMFTLS-ILLMAIPTLAIGLLPTyasmgilaPLLLLLMRILQGAAIGGEVPgAWVFVAEHVPERRIGIACGT 157
Cdd:cd17490 54 LSDRIGKRKLFIIIgLLFTVLASLIMILFPS--------PWGLLIARFLSGIAAATWVS-FTVLYASYFPPDEAAKAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 158 LTAGLTVGILLGSVVATLVNTSltqqavhdYGWRIPFLLGGVFGLVAMYLRRWLQETPiflemqqrkalAQELPVKSVVS 237
Cdd:cd17490 125 INLVNNLGQLIAFLIGGLIAEH--------FGMRAPFLLAALAGVLGFILSLFIKEER-----------REKKPVLTELK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 238 KHKKAVVISMLLTWLLSAGIVVVILMSPVW-----LQKQYGFAPALTLQANSVATIMLCVGCLLAGFI-VDRVGASKTFI 311
Cdd:cd17490 186 ELLSVLKDKKLLFFSLLAILQQMITFSTTFgftplIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTII 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 312 VGSLLLACSSwfFYHLTGSHPQHLFLLYGLVGLCVGVVgaVPYVM---VRAFPAEVRFTGISFsYNVSYAIFGGLTPIAV 388
Cdd:cd17490 266 IGFLLLGAYC--FLIPFAPNLTLLYLLQALNGFGTGIL--FPLLMslsIEGVPAEQRSTAMGF-FQAIYALGMFLGPVLV 340
|
330 340
....*....|....*....|...
gi 507080879 389 TMLMSVSPMAPAWYVLA-LSLVG 410
Cdd:cd17490 341 GIISEAFGLQTGFFVIGvIALLA 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
247-420 |
6.00e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.63 E-value: 6.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 247 MLLTWLLSAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFYH 326
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 327 LTGShpQHLFLLYGLVGLCVGVVGAVPYVMV-RAFPAEVRFTGISFsYNVSYAIFGGLTPIAVTMLMSVSPMAPAWYVLA 405
Cdd:pfam07690 82 ASSL--WLLLVLRVLQGLGAGALFPAALALIaDWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|....*
gi 507080879 406 LSLVGLGLGIWLRQD 420
Cdd:pfam07690 159 ILSLLAAVLLLLPRP 173
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
61-384 |
9.25e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 41.44 E-value: 9.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 61 IFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllmRILQGAaIGGEVPGAWV 140
Cdd:PRK09874 59 VFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLIL--------RALLGL-LGGFVPNANA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 141 FVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVNTSltqqavhdYGWRIPFLLGGVFGLVAMYLrrwlqeTPIFL-E 219
Cdd:PRK09874 130 LIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADS--------YGLRPVFFITASVLFLCFLV------TLFCIrE 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 220 MQQRKALAQELPVKSVVSKHKKA-VVISMLLTWLL---SAGIVVVILMspVWLQKQYGFAPALTLQANSVATIMLCVGCL 295
Cdd:PRK09874 196 NFQPVSKKEMLHMREVVTSLKNPkLVLSLFVTTLIiqvATGSIAPILT--LYVRELAGNVSNIAFISGMIASVPGVAALL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 296 LA---GFIVDRVGASKTFIVG---SLLLACSSWFFyhltgSHPQHLFLLYGLVGLCVG-VVGAVPYVMVraFPAEVRFTG 368
Cdd:PRK09874 274 SAprlGKLGDRIGPEKILITAlifSVLLLIPMSFV-----QTPLQLGILRFLLGAADGaLLPAVQTLLV--YNSSNQIAG 346
|
330
....*....|....*.
gi 507080879 369 ISFSYNVSYAIFGGLT 384
Cdd:PRK09874 347 RIFSYNQSFRDIGNVT 362
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
283-413 |
9.26e-04 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 41.50 E-value: 9.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 283 NSVATIMLCVGCLLAGFIVDRVGaSKTFIVGSLLLACSSWFFYHLTGSHPQHLFLLYGLVGLCVGVVGAVPYVMVRAFPA 362
Cdd:TIGR01299 601 NFLGTLAVLPGNIVSALLMDKIG-RLRMLAGSMVLSCISCFFLSFGNSESAMIALLCLFGGLSIAAWNALDVLTVELYPS 679
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 507080879 363 EVRFTGISF--SYNVSYAIFGGLTPIAVTMLMSVSPMAPAWYVLAL-SLVGLGL 413
Cdd:TIGR01299 680 DKRATAFGFlnALCKAAAVLGILIFGSFVGITKAAPILFASAALACgGLLALKL 733
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
250-419 |
1.03e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.01 E-value: 1.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 250 TWLLSAGIVVVI--LMSPVW--------LQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLAC 319
Cdd:COG2807 16 RWLLLLAIVLVAlnLRPAITsvgpllpeIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 320 SSWFFYHLTGshPQHLFLLYGLVGLCVGVVGAV-PYVMVRAFPAEVRF-TGIsfsYNVSYAIFGGLTPIAVTMLMSVSPM 397
Cdd:COG2807 96 GLLLRSLAPS--VALLLAGTALIGAGIAVGNVLlPGLIKRWFPDRVGLmTGL---YTAAMGLGAALAAGLTVPLAAALGW 170
|
170 180
....*....|....*....|..
gi 507080879 398 APAWYVLALsLVGLGLGIWLRQ 419
Cdd:COG2807 171 RGALAVWAL-LALLALLLWLPL 191
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
60-211 |
1.42e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 40.62 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 60 GIFAAGYLarpLGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGILAplllllMRILQGAAIGGEVPGAW 139
Cdd:cd17380 41 SSFFWGYA---LTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLIL------SRILLGLGEGVHFPSMT 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507080879 140 VFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYLRRWL 211
Cdd:cd17380 112 SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLL--------LEYYGWPSVFYFFGLLGLLWALVWLIY 175
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
28-205 |
1.47e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 28 YDFIIFVFFAAVVGELFFPADIP------EWLRQVQTFGIFAAGYLARPLGGIIMAHFGDLVGRKKMFTLSILLMAIPTL 101
Cdd:cd17370 200 KAFWLYLLAVALFALGNFSFAFLilraqeLGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 102 AIGLLPTYASMGILAplllllmrILQGAAIGGEVPGAWVFVAEHVPERRIGIACGTLTAGLTVGILLGSVVATLVntslt 181
Cdd:cd17370 280 GFALGSSLWLLLLGF--------ILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL----- 346
|
170 180
....*....|....*....|....
gi 507080879 182 qqaVHDYGWRIPFLLGGVFGLVAM 205
Cdd:cd17370 347 ---WDLISPSAAFLFSAVLALIAL 367
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
80-318 |
2.51e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 80 GDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMGIlaplllllMRILQGAAIGGEVPGAWVFVAE-HVPERRIGIACGTL 158
Cdd:cd17476 57 GDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFII--------CRALQGLGPAFLLPNAMALLGRtYPPGPRKNIVFSLF 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 159 TAGLTVGILLGSVVATLvntsLTQQAvhdyGWR-IPFLLGGVFGLVAMYLRRWLqetpiflemqqrkalaqelpvksvvS 237
Cdd:cd17476 129 GATAPLGFALGGVFGGL----FAQLA----WWPwIFWFLAILAAIVAVAAIFWT-------------------------S 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 238 KHKKAVVISMLLTWlLSAGIVVVILMSpvWLQKQYGFAPALTLQANSVATIMLCVGCLLAGFIVDRVGASK-------TF 310
Cdd:cd17476 176 PSFIAVLLAVFLGW-ASFGIWVFYATQ--YFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYimaismvAF 252
|
....*...
gi 507080879 311 IVGSLLLA 318
Cdd:cd17476 253 LVGPILFA 260
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
71-376 |
3.59e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 39.55 E-value: 3.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 71 LGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLlptyaSMGILAPLLLLLMRILQGAAIGGEVPGAWVFVAEHVPERR 150
Cdd:cd17357 64 IGSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSEL 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 151 IGiACGTLTA-GLTVGILLGSVVAtlvntsLTQQAVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPIFLEMQQ------R 223
Cdd:cd17357 139 RG-ALGSLTQiGVTLGILLGQVFG------LPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKgdeeeaE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 224 KALA----QELPVKSVVSKHKK--------------------------AVVISMLLTWLLSaGIVVVILMSpVWLQKQYG 273
Cdd:cd17357 212 KSLKflrgIEDDVDQELEEIKKeseqmgdqkqvslmqllrdpslrlplLLVLVVSASQQFS-GINAIFFYS-TFIFENAG 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 274 FAPALTLQANSVATIMLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFYHLTGSHPQHLFLLYGLVGLCVG------ 347
Cdd:cd17357 290 FSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGCIVAIFLfifffa 369
|
330 340 350
....*....|....*....|....*....|.
gi 507080879 348 -VVGAVPYVMVRA-FPAEVRFTGISFSYNVS 376
Cdd:cd17357 370 iGLGPIPWFIGAElFPQAPRSAAQSLGSSVN 400
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
58-401 |
4.30e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 4.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 58 TFGIFAAGyLARPLGGIIMAHFGDlvgrKKMFTLSILLMAIPTLAIGLLPTYASMGILaplllllMRILQGAAIGGEVPG 137
Cdd:cd17355 45 TVGLLAFG-LAQPFVGRLLDRFGP----RRVMLLGLLLLAAGLVLLALATSLWQLYLL-------WGLLGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 138 AWVFVAEHVPERRIGIACGTLTAGLTVGILLGSvvatlvntSLTQQAVHDYGWRIPFLLGGVFGLVAMylrrwlqeTPIF 217
Cdd:cd17355 113 AFATVAAWWFERRRGLALGILTAGGGLGSLVFL--------PLGAALIEAFGWRTALLVLALLALLVL--------VPVL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 218 LEMQQRKALAQELPVKSVVSKHKKAVVISML---LTWLLSAGIVVV------ILMSPVWLQKQYGFAPALTLQANSVATI 288
Cdd:cd17355 177 LLLRRRPADLALRAYDDASPASPGSTLKEALrsaSFWLLALAFFLCgfavvgLIVHLVPYLADRGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 289 MLCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFyhLTGSHPQHLFLLYG-LVGLCVGVVGAVP-YVMVRAFPAEvrf 366
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALL--LLLPFPPLALLLFAaLFGLGWGATVPLTaALAARYFGAR--- 331
|
330 340 350
....*....|....*....|....*....|....*
gi 507080879 367 tgisfsynvSYAIFGGLTPIAVTMLMSVSPMAPAW 401
Cdd:cd17355 332 ---------SYGTLFGLVFAPHQLGSALGPWLGGL 357
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
57-347 |
5.75e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 5.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 57 QTFGIFAAGYLARPLGGIIMAHFGDLvgrkkMFTLSILLMAIptlAIGLLPTYASMGILAplllllmrilqGAAIGGEVP 136
Cdd:cd17353 51 LAISAPFAGRLVDRGGPRKAILIGGI-----LFGLGFILSAF---AISLPLLFLGYGVLG-----------GIGAGIGYI 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 137 GAWVFVAEHVPERRiGIACGTLTAGLTVGILLGSVVATLVntsltqqaVHDYGWRIPFLLGGVFGLVAMYLRRWLQETPI 216
Cdd:cd17353 112 TPVSTAVKWFPDKR-GLATGIVIAGFGLGSLIFSPLIAYL--------INTVGVPTTFLILGIIFLIIIVIGAFLIRDPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 217 FLEMQQRKALAQELPVKSVVSKHKKAVVISMLlTWLL-------SAGIVVVILMSPVWLQKQYGFAPALTLQANSVATIM 289
Cdd:cd17353 183 KGWVPPGVDPLANNAENSPRDYTPREMLRTPT-FWLLwlmfflnATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIF 261
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 507080879 290 LCVGCLLAGFIVDRVGASKTFIVGSLLLACSSWFFYhLTGSHPQHLFLLYGLVGLCVG 347
Cdd:cd17353 262 NGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLP-FIGSVAVLFVLGVALIGFCYG 318
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
63-409 |
9.63e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 38.05 E-value: 9.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 63 AAGYLArplgGIIMAHFGDLVGR-KKMFTLSILLMAIPTLAIGLLPTYAsmgilaplLLLLMRILQGAAiggevpGAWVF 141
Cdd:cd06180 44 YAGYLV----GALLASFLRRRGRaRRLIRGGLLLTVLLLAAMALTSGFA--------ALLALRFLAGAA------SAFVF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 142 VA------EHVPERRIGIACGTLTAGLTVGILLGSVVATLVNtsltqqaVHDYGWRIPFLLGGVFGLVAMYLRRWLQETP 215
Cdd:cd06180 106 VFgsnlvlHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGL-------GGGLSWRAGWLALALLSAVLLLLSFLLLRRG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 216 iflemqqRKALAQELPVKSVVSKHKKAVVISMLLTwLLSAGIVVVILMSPVWLQKQyGFAPALTLQANSVATIMLCVGCL 295
Cdd:cd06180 179 -------PSAPTEASAAESAPGLNRPLWRLALAYG-LFGFGYIITATFLPLIARET-GAGSLLAGLLWSLFGLAAVPSCF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 296 LAGFIVDRVGASKTFIVGSLLLACSswffYHLTGSHPQHLFLLYGLVGLCVGVVGAVPYVM--VRAFPAEVRFTGISFsY 373
Cdd:cd06180 250 LWGALSDRWGTRRALAANLLVQAVG----VLLPLLSPGPAGLVLSAVLFGGTFMAITALVMalARELAPPAAPRALAL-M 324
|
330 340 350
....*....|....*....|....*....|....*..
gi 507080879 374 NVSYAIFGGLTPIAVTMLMSVS-PMAPAWYVLALSLV 409
Cdd:cd06180 325 TASFGVGQILGPLLAGWLADATgGFAPALILAAAALV 361
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|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
71-379 |
9.72e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 38.10 E-value: 9.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 71 LGGIIMAHFGDLVGRKKMFTLSILLMAIPTLAIGLLPTYASMgilaplllLLMRILQGAAIGGEVPGAWVFVAEHVPERR 150
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVL--------LVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 151 IGIACGTLTAGLTVGILLGSVVAtlvntSLTQQAVHdyGWRIPFLLGGVFGLVAMYLRRWLQETPIFlEMQQRKALaqel 230
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSG-----YAFADVVG--GWRYMYGLAAPPALLLGIGMWFLPPSPRW-QGNYRKPL---- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 231 pvksvvskhkkaVVISMLLTWLLSAGIVVVILMSPVWLQKQyGFAPALTLQANSVA-----TIMLCVgcllAGFIVDRVG 305
Cdd:cd17362 194 ------------IIGLGLVLFQQITGQPSVLYYAATIFKSA-GFSAASDATLVSVGlgvfkLLMTIV----AVLLVDKLG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507080879 306 ASKTFIVG-SLLLACSSWFFYHLTGSHPQHLFLLY-GLVGLCVGV------VGAVPYVMV-RAFPAEVRFTGISFSYNVS 376
Cdd:cd17362 257 RRPLLLGGvSGMVVSLFLLAAYNLFVQMGPAGLAWlSLVALLLYVgayqisFGPISWLMVsEIFPLRVRGRAIALAVLVN 336
|
...
gi 507080879 377 YAI 379
Cdd:cd17362 337 FGS 339
|
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