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Conserved domains on  [gi|507082350|ref|WP_016153099|]
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MULTISPECIES: 3-hydroxyacyl-CoA dehydrogenase family protein [Citrobacter]

Protein Classification

3-hydroxyacyl-CoA dehydrogenase family protein( domain architecture ID 11441205)

3-hydroxyacyl-CoA dehydrogenase (HCDH) family protein such as mitochondrial HCDH, which plays an essential role in the beta-oxidation of short chain fatty acids

CATH:  3.40.50.720|1.10.1040.10
EC:  1.1.1.-
Gene Ontology:  GO:0003857|GO:0006635|GO:0070403
PubMed:  3479790
SCOP:  4000107

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 4-285 2.33e-96

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 285.85  E-value: 2.33e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDIAAC 83
Cdd:COG1250    3 KKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALADA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  84 GLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPEy 163
Cdd:COG1250   83 DLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDE- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 164 lqelqqlllsmqleavVLDRAA----------------PGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRy 227
Cdd:COG1250  162 ----------------TVATAVafarrlgktpvvvkdtPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFP- 224

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 507082350 228 amVGPLEAADMTGLSTVQDICRHLLPELATGSDMMS-LVADKVANGDTGLRSGQGFYRW 285
Cdd:COG1250  225 --MGPFELADLVGLDTALAVLEVLYEALGDPRYRPPpLLKKLVEAGRLGRKTGRGFYDY 281
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 4-285 2.33e-96

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 285.85  E-value: 2.33e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDIAAC 83
Cdd:COG1250    3 KKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALADA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  84 GLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPEy 163
Cdd:COG1250   83 DLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDE- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 164 lqelqqlllsmqleavVLDRAA----------------PGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRy 227
Cdd:COG1250  162 ----------------TVATAVafarrlgktpvvvkdtPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFP- 224

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 507082350 228 amVGPLEAADMTGLSTVQDICRHLLPELATGSDMMS-LVADKVANGDTGLRSGQGFYRW 285
Cdd:COG1250  225 --MGPFELADLVGLDTALAVLEVLYEALGDPRYRPPpLLKKLVEAGRLGRKTGRGFYDY 281
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 4-301 2.53e-76

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 235.82  E-value: 2.53e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSN---RIADIGAVASGILDeliateqfPKNDKEQAVSRLHGTTSLHD- 79
Cdd:PRK06130   5 QNLAIIGAGTMGSGIAALFARKGLQVVLIDVMEGaleRARGVIERALGVYA--------PLGIASAGMGRIRMEAGLAAa 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  80 IAACGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTAT 159
Cdd:PRK06130  77 VSGADLVIEAVPEKLELKRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVTRPERFVGTHFFTPADVIPLVEVVRGDKT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 160 KPEYLQELQQLLLSMQLEAVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVGPLEAADMT 239
Cdd:PRK06130 157 SPQTVATTMALLRSIGKRPVLVKKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRLALTGPLEQRDMN 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507082350 240 GLSTVQDICRHLLPELATGSDMMSLVADKVANGDTGLRSGQGFYRWDDSRKEYIQQRREHQL 301
Cdd:PRK06130 237 GLDVHLAVASYLYQDLENRTTPSPLLEEKVEAGELGAKSGQGFYAWPPERREEVLADKSAAL 298
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 5-162 5.18e-54

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 173.88  E-value: 5.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350    5 HICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDIAACG 84
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDAALARISFTTDLAAAVDAD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507082350   85 LLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPE 162
Cdd:pfam02737  81 LVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPE 158
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 4-290 1.39e-28

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 115.32  E-value: 1.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350    4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIA-DIGAVASGiLDELIATEQFPKNDKEQAVSRLHGTTSLHDIAA 82
Cdd:TIGR02441 336 KTLAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAGLDrGQQQVFKG-LNKKVKRKKITSLERDSILSNLTPTLDYSGFKN 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   83 CGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPE 162
Cdd:TIGR02441 415 ADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSKD 494

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  163 yLQELQQLLLSMQLEAVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVvdqvmrASLGRRYAM-VGPLEAADMTGL 241
Cdd:TIGR02441 495 -TLASAVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQEGVDPKKL------DKLTTKFGFpVGAATLADEVGV 567

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 507082350  242 ST----VQDICRHLLPELATGSdmMSLVADKVANGDTGLRSGQGFYRWDDSRK 290
Cdd:TIGR02441 568 DVaehvAEDLGKAFGERFGGGS--AELLSELVKAGFLGRKSGKGIFIYQEGKK 618
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 4-285 2.33e-96

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 285.85  E-value: 2.33e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDIAAC 83
Cdd:COG1250    3 KKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALADA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  84 GLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPEy 163
Cdd:COG1250   83 DLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDE- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 164 lqelqqlllsmqleavVLDRAA----------------PGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRy 227
Cdd:COG1250  162 ----------------TVATAVafarrlgktpvvvkdtPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFP- 224

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 507082350 228 amVGPLEAADMTGLSTVQDICRHLLPELATGSDMMS-LVADKVANGDTGLRSGQGFYRW 285
Cdd:COG1250  225 --MGPFELADLVGLDTALAVLEVLYEALGDPRYRPPpLLKKLVEAGRLGRKTGRGFYDY 281
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 4-301 2.53e-76

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 235.82  E-value: 2.53e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSN---RIADIGAVASGILDeliateqfPKNDKEQAVSRLHGTTSLHD- 79
Cdd:PRK06130   5 QNLAIIGAGTMGSGIAALFARKGLQVVLIDVMEGaleRARGVIERALGVYA--------PLGIASAGMGRIRMEAGLAAa 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  80 IAACGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTAT 159
Cdd:PRK06130  77 VSGADLVIEAVPEKLELKRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVTRPERFVGTHFFTPADVIPLVEVVRGDKT 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 160 KPEYLQELQQLLLSMQLEAVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVGPLEAADMT 239
Cdd:PRK06130 157 SPQTVATTMALLRSIGKRPVLVKKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRLALTGPLEQRDMN 236

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507082350 240 GLSTVQDICRHLLPELATGSDMMSLVADKVANGDTGLRSGQGFYRWDDSRKEYIQQRREHQL 301
Cdd:PRK06130 237 GLDVHLAVASYLYQDLENRTTPSPLLEEKVEAGELGAKSGQGFYAWPPERREEVLADKSAAL 298
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 5-238 3.34e-59

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 191.79  E-value: 3.34e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   5 HICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHD-IAAC 83
Cdd:PRK06129   4 SVAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGEAPDAVLARIRVTDSLADaVADA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  84 GLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPEY 163
Cdd:PRK06129  84 DYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPAT 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 507082350 164 LQELQQLLLSMQLEAVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVGPLEAADM 238
Cdd:PRK06129 164 LARAEALYRAAGQSPVRLRREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRWSFMGPFETIDL 238
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
4-288 3.75e-55

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 180.76  E-value: 3.75e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDIAA- 82
Cdd:PRK09260   2 EKLVVVGAGVMGRGIAYVFAVSGFQTTLVDIKQEQLESAQQEIASIFEQGVARGKLTEAARQAALARLSYSLDLKAAVAd 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  83 CGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPE 162
Cdd:PRK09260  82 ADLVIEAVPEKLELKKAVFETADAHAPAECYIATNTSTMSPTEIASFTKRPERVIAMHFFNPVHKMKLVELIRGLETSDE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 163 YLQELQQLLLSMQLEAVVLDRaAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRasLGRRYAMvGPLEAADMTGLS 242
Cdd:PRK09260 162 TVQVAKEVAEQMGKETVVVNE-FPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIR--LGLNFPM-GPLELGDLVGLD 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 507082350 243 TVQDICRHLLPELATGSDMMSLVADKVANGDTGLRSGQGFYRWDDS 288
Cdd:PRK09260 238 TRLNNLKYLHETLGEKYRPAPLLEKYVKAGRLGRKTGRGVYDYTNR 283
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 5-162 5.18e-54

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 173.88  E-value: 5.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350    5 HICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDIAACG 84
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDAALARISFTTDLAAAVDAD 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507082350   85 LLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPE 162
Cdd:pfam02737  81 LVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPE 158
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 1-283 2.61e-53

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 175.54  E-value: 2.61e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   1 MKSKHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDI 80
Cdd:PRK05808   1 MGIQKIGVIGAGTMGNGIAQVCAVAGYDVVMVDISDAAVDRGLATITKSLDRLVKKGKMTEADKEAALARITGTTDLDDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  81 AACGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATK 160
Cdd:PRK05808  81 KDADLVIEAATENMDLKKKIFAQLDEIAKPEAILATNTSSLSITELAAATKRPDKVIGMHFFNPVPVMKLVEIIRGLATS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 161 PEYLQELQQLLLSMQLEAVVLdRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRasLGRRYAMvGPLEAADMTG 240
Cdd:PRK05808 161 DATHEAVEALAKKIGKTPVEV-KNAPGFVVNRILIPMINEAIFVLAEGVATAEDIDEGMK--LGCNHPI-GPLALADLIG 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 507082350 241 LSTVQDICRHLLPElaTGSDMM---SLVADKVANGDTGLRSGQGFY 283
Cdd:PRK05808 237 LDTCLAIMEVLYEG--FGDSKYrpcPLLRKMVAAGWLGRKTGRGFY 280
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 1-291 7.56e-51

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 175.03  E-value: 7.56e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   1 MKSKHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSnriadiGAVASGI------LDELIATEQFPKNDKEQAVSRLHGT 74
Cdd:PRK08268   5 PSIATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARA------GAAAAARdgiaarLAKLVEKGKLTAEQADAALARLRPV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  75 TSLHDIAACGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIV 154
Cdd:PRK08268  79 EALADLADCDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEVV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 155 PGTATKPEYLQELQQLLLSMQLEAVVLdRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRyaMvGPLE 234
Cdd:PRK08268 159 SGLATDPAVADALYALARAWGKTPVRA-KDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAILREAAGFR--M-GPFE 234

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507082350 235 AADMTGLS---TV---------QDicRHLLPELATgsdmmslvADKVANGDTGLRSGQGFYRWDDSRKE 291
Cdd:PRK08268 235 LMDLIGLDvnhAVmesvyrqfyQE--PRFRPSLIQ--------QELVAAGRLGRKSGQGFYRYADGAKQ 293
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 4-286 6.08e-49

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 164.90  E-value: 6.08e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDIAAC 83
Cdd:PLN02545   5 KKVGVVGAGQMGSGIAQLAAAAGMDVWLLDSDPAALSRGLDSISSSLARLVKKGKMSQEEADATLGRIRCTTNLEELRDA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  84 GLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPEy 163
Cdd:PLN02545  85 DFIIEAIVESEDLKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQQVIGMHFMNPPPIMKLVEIIRGADTSDE- 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 164 LQELQQLLLSMQLEAVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRasLGRRYAMvGPLEAADMTGLST 243
Cdd:PLN02545 164 VFDATKALAERFGKTVVCSQDYPGFIVNRILMPMINEAFYALYTGVASKEDIDTGMK--LGTNHPM-GPLHLADFIGLDT 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 507082350 244 VQDICRHLLPELATGSDMM-SLVADKVANGDTGLRSGQGFYRWD 286
Cdd:PLN02545 241 CLSIMKVLHEGLGDSKYRPcPLLVQYVDAGRLGRKSGRGVYHYD 284
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 1-291 3.76e-43

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 149.77  E-value: 3.76e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   1 MKSKHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDI 80
Cdd:PRK07530   2 MAIKKVGVIGAGQMGNGIAHVCALAGYDVLLNDVSADRLEAGLATINGNLARQVAKGKISEEARAAALARISTATDLEDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  81 AACGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTAT- 159
Cdd:PRK07530  82 ADCDLVIEAATEDETVKRKIFAQLCPVLKPEAILATNTSSISITRLASATDRPERFIGIHFMNPVPVMKLVELIRGIATd 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 160 KPEYLQELQQLLLSMQLEAVVLDraAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRasLGRRYAMvGPLEAADMT 239
Cdd:PRK07530 162 EATFEAAKEFVTKLGKTITVAED--FPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMK--LGANHPM-GPLELADFI 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 507082350 240 GLSTVQDICRHLLPELA-TGSDMMSLVADKVANGDTGLRSGQGFYrwdDSRKE 291
Cdd:PRK07530 237 GLDTCLSIMQVLHDGLAdSKYRPCPLLVKYVEAGWLGRKTGRGFY---DYRGE 286
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 8-283 9.81e-43

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 148.21  E-value: 9.81e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   8 VLGAGLMGVGIATHFVRYGHDVWLYDTDSnRIADIG----------AVASGILDEliateqfpkNDKEQAVSRLHGTTSL 77
Cdd:PRK07819  10 VVGAGQMGAGIAEVCARAGVDVLVFETTE-ELATAGrnriekslerAVSRGKLTE---------RERDAALARLRFTTDL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  78 HDIAACGLLIEAIPERLELKHALYAQLEALIA-PEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPG 156
Cdd:PRK07819  80 GDFADRQLVIEAVVEDEAVKTEIFAELDKVVTdPDAVLASNTSSIPIMKLAAATKRPGRVLGLHFFNPVPVLPLVELVPT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 157 TATKPEYLQELQQLLLSMQLEAVVL--DRAapGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRasLGRRYAMvGPLE 234
Cdd:PRK07819 160 LVTSEATVARAEEFASDVLGKQVVRaqDRS--GFVVNALLVPYLLSAIRMVESGFATAEDIDKAMV--LGCAHPM-GPLR 234

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 507082350 235 AADMTGLSTVQDICRHLLPELATGS-DMMSLVADKVANGDTGLRSGQGFY 283
Cdd:PRK07819 235 LSDLVGLDTVKAIADSMYEEFKEPLyAPPPLLLRMVEAGLLGKKSGRGFY 284
PRK07531 PRK07531
carnitine 3-dehydrogenase;
1-234 5.03e-41

carnitine 3-dehydrogenase;


Pssm-ID: 236044 [Multi-domain]  Cd Length: 495  Bit Score: 148.73  E-value: 5.03e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   1 MKSKHICVlGAGLMGVGIATHFVRYGHDVWLYDTDSNriadigavASGILDELIAteqfpknDKEQAVSRL-------HG 73
Cdd:PRK07531   3 MIMKAACI-GGGVIGGGWAARFLLAGIDVAVFDPHPE--------AERIIGEVLA-------NAERAYAMLtdaplppEG 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  74 TTSLHD-----IAACGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFI 148
Cdd:PRK07531  67 RLTFCAslaeaVAGADWIQESVPERLDLKRRVLAEIDAAARPDALIGSSTSGFLPSDLQEGMTHPERLFVAHPYNPVYLL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 149 PLVEIVPGTATKPEYLQELQQLLLSMQLEAVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYA 228
Cdd:PRK07531 147 PLVELVGGGKTSPETIRRAKEILREIGMKPVHIAKEIDAFVGDRLLEALWREALWLVKDGIATTEEIDDVIRYSFGLRWA 226


                 ....*.
gi 507082350 229 MVGPLE 234
Cdd:PRK07531 227 QMGLFE 232
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 14-296 2.29e-40

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 142.89  E-value: 2.29e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  14 MGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKN----DKEQA------VSRLHGTTSLHDIAAC 83
Cdd:PRK08269   1 MGQGIALAFAFAGHDVTLIDFKPRDAAGWRALDAEARAEIERTLAALVAlgriDAAQAdavlarIAVVARDGAADALADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  84 GLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPEY 163
Cdd:PRK08269  81 DLVFEAVPEVLDAKREALRWLGRHVDADAIIASTTSTFLVTDLQRHVAHPERFLNAHWLNPAYLMPLVEVSPSDATDPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 164 LQELQQLLLSMQLEAVVLdRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVGPLEAADMTGLST 243
Cdd:PRK08269 161 VDRLAALLERIGKVPVVC-GPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDKAIRTGFGLRFAVLGLLEFIDWGGCDI 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 507082350 244 VQDICRHLlpELATGSDMMS---LVADKVANGDTGLRSGQGFYRWDD-SRKEYIQQR 296
Cdd:PRK08269 240 LYYASRYL--AGEIGPDRFAppaIVVRNMEEGRDGLRTGAGFYDYAGvDVPAYRRQR 294
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
1-285 1.02e-34

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 127.36  E-value: 1.02e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   1 MKSKHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIAD----IGAVASGILDELIATeqfPKNDKEQAVSRLHGTTS 76
Cdd:PRK08293   1 MDIKNVTVAGAGVLGSQIAFQTAFHGFDVTIYDISDEALEKakerIAKLADRYVRDLEAT---KEAPAEAALNRITLTTD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  77 LhDIAACG--LLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIV 154
Cdd:PRK08293  78 L-AEAVKDadLVIEAVPEDPEIKGDFYEELAKVAPEKTIFATNSSTLLPSQFAEATGRPEKFLALHFANEIWKNNTAEIM 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 155 PGTATKPEYLQELQQLLLSMQLEAVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGrryAMVGPLE 234
Cdd:PRK08293 157 GHPGTDPEVFDTVVAFAKAIGMVPIVLKKEQPGYILNSLLVPFLSAALALWAKGVADPETIDKTWMIATG---APMGPFG 233

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 507082350 235 AADMTGLSTVQDICRHlLPElATGSDMMSLVADKVAN----GDTGLRSGQGFYRW 285
Cdd:PRK08293 234 ILDIVGLDTAYNITSN-WAE-ATDDENAKKAAALLKEyidkGKLGVATGEGFYNY 286
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 1-254 1.24e-32

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 121.91  E-value: 1.24e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   1 MKSKHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIAD-IGAVASGI--LDELIATEQFPKNDKEQAVSRLHGTTSL 77
Cdd:PRK06035   1 MDIKVIGVVGSGVMGQGIAQVFARTGYDVTIVDVSEEILKNaMELIESGPygLRNLVEKGKMSEDEAKAIMARIRTSTSY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  78 HDIAACGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGT 157
Cdd:PRK06035  81 ESLSDADFIVEAVPEKLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALERKDRFIGMHWFNPAPVMKLIEVVRAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 158 ATKPE-YLQELQQLLLSMQLEAVVLDraAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGrrYAMvGPLEAA 236
Cdd:PRK06035 161 LTSEEtFNTTVELSKKIGKIPIEVAD--VPGFFTTRFIEGWLLEAIRSFEIGIATIKDIDEMCKLAFG--FPM-GPFELM 235

                        250
                 ....*....|....*...
gi 507082350 237 DMTGLSTVQDICRHLLPE 254
Cdd:PRK06035 236 DIIGIDTVYHIAEYLYEE 253
PRK07066 PRK07066
L-carnitine dehydrogenase;
4-231 1.34e-29

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 114.55  E-value: 1.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEqavsRLHGTTSLHD-IAA 82
Cdd:PRK07066   8 KTFAAIGSGVIGSGWVARALAHGLDVVAWDPAPGAEAALRANVANAWPALERQGLAPGASPA----RLRFVATIEAcVAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  83 CGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPE 162
Cdd:PRK07066  84 ADFIQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGERTAPE 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 507082350 163 YLQELQQLLLSMQLEAVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYAMVG 231
Cdd:PRK07066 164 AVDAAMGIYRALGMRPLHVRKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRWSFMG 232
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 4-290 1.39e-28

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 115.32  E-value: 1.39e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350    4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIA-DIGAVASGiLDELIATEQFPKNDKEQAVSRLHGTTSLHDIAA 82
Cdd:TIGR02441 336 KTLAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAGLDrGQQQVFKG-LNKKVKRKKITSLERDSILSNLTPTLDYSGFKN 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   83 CGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPE 162
Cdd:TIGR02441 415 ADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSKD 494

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  163 yLQELQQLLLSMQLEAVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVvdqvmrASLGRRYAM-VGPLEAADMTGL 241
Cdd:TIGR02441 495 -TLASAVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQEGVDPKKL------DKLTTKFGFpVGAATLADEVGV 567

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 507082350  242 ST----VQDICRHLLPELATGSdmMSLVADKVANGDTGLRSGQGFYRWDDSRK 290
Cdd:TIGR02441 568 DVaehvAEDLGKAFGERFGGGS--AELLSELVKAGFLGRKSGKGIFIYQEGKK 618
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
4-290 2.96e-27

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 111.49  E-value: 2.96e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIaDIG-AVASGILDELIATEQFPKNDKEQAVSRLHGTTSLHDIAA 82
Cdd:PRK11730 314 KQAAVLGAGIMGGGIAYQSASKGVPVIMKDINQKAL-DLGmTEAAKLLNKQVERGKIDGAKMAGVLSSIRPTLDYAGFER 392

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  83 CGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTATKPE 162
Cdd:PRK11730 393 VDVVVEAVVENPKVKAAVLAEVEQKVREDTILASNTSTISISLLAKALKRPENFCGMHFFNPVHRMPLVEVIRGEKTSDE 472

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 163 YLqelqqlllsmqleAVVLDRAA------------PGFVGNRLQFALLREALHIVKSGiASAEVVDQVMRASLGrrYAMv 230
Cdd:PRK11730 473 TI-------------ATVVAYASkmgktpivvndcPGFFVNRVLFPYFAGFSQLLRDG-ADFRQIDKVMEKQFG--WPM- 535

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507082350 231 GPLEAADMTGLST---VQDICRHLLPElATGSDMMSLVADKVANGDTGLRSGQGFYRWDDSRK 290
Cdd:PRK11730 536 GPAYLLDVVGIDTahhAQAVMAEGFPD-RMKKDYRDAIDVLFEAKRFGQKNGKGFYRYEEDKK 597
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
2-295 5.08e-24

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 101.90  E-value: 5.08e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   2 KSKHICVLGAGLMGVGIAthFV---RYGHDVWLYDTDSNRIADIGAVASGILDELIATEQFPKNDKEQAVSRLHGTTSLH 78
Cdd:PRK11154 308 PVNKVGVLGGGLMGGGIA--YVtatKAGLPVRIKDINPQGINHALKYSWDLLDKKVKRRHLKPSERDKQMALISGTTDYR 385

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  79 DIAACGLLIEAIPERLELKHALYAQLEALIAPEAVIASNTSGLPPDALAEKLAHPERLLIAHFWHPPHFIPLVEIVPGTA 158
Cdd:PRK11154 386 GFKHADVVIEAVFEDLALKQQMVAEVEQNCAPHTIFASNTSSLPIGQIAAAAARPEQVIGLHYFSPVEKMPLVEVIPHAK 465

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 159 TKPEYLQELQQLLLSMQLEA-VVLDRAapGFVGNRLQFALLREALHIVKSGiASAEVVDqvmrASLGRRYAMVGPLEAAD 237
Cdd:PRK11154 466 TSAETIATTVALAKKQGKTPiVVRDGA--GFYVNRILAPYINEAARLLLEG-EPIEHID----AALVKFGFPVGPITLLD 538

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350 238 MTGLSTVQDICRHLLPELatGSDMMS--LVADKVANGDTGLRSGQGFYRWDDSRKEYIQQ 295
Cdd:PRK11154 539 EVGIDVGTKIIPILEAAL--GERFSApaAFDKLLNDDRKGRKNGRGFYLYGQKGKKSKKQ 596
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 187-285 1.55e-20

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 84.19  E-value: 1.55e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350  187 GFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGRRYamvGPLEAADMTGLSTVQDICRHLLPEL-ATGSDMMSLV 265
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPM---GPFELSDLVGLDVGYHILEVLAEEFgDRAYRPPPLL 77

                          90       100
                  ....*....|....*....|
gi 507082350  266 ADKVANGDTGLRSGQGFYRW 285
Cdd:pfam00725  78 EKLVEAGRLGRKTGKGFYKY 97
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 4-136 2.57e-04

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 41.95  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507082350   4 KHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADIGA------VASGIldeliateQFPKNdkeqavsrLHGTTSL 77
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINEtrenprYLPGV--------KLPEN--------LRATSDL 64

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507082350  78 HD-IAACGLLIEAIPERlELKHALyAQLEALIAPEAVIAS-------NTSGLPPDALAEKLAHPERL 136
Cdd:COG0240   65 EEaLAGADLVLLAVPSQ-ALREVL-EQLAPLLPPGAPVVSatkgiepGTGLLMSEVIAEELPGALRI 129
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 178-251 3.55e-04

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 41.76  E-value: 3.55e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507082350 178 AVVLDRAAPGFVGNRLQFALLREALHIVKSGIASAEVVDQVMRASLGrrYAMvGPLEAADMTGLSTVQDICRHL 251
Cdd:PRK08268 407 AVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLN--YPL-GPLAWGDRLGAARILRVLENL 477
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 3-48 2.54e-03

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 38.94  E-value: 2.54e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 507082350   3 SKHICVLGAGLMGVGIATHFVRYGHDVWLYDTDSNRIADigAVASG 48
Cdd:COG2084    1 MMKVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAKAEA--LVAAG 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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