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Conserved domains on  [gi|510817277|ref|WP_016190814|]
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DgaE family pyridoxal phosphate-dependent ammonia lyase [Erwinia tracheiphila]

Protein Classification

DgaE family pyridoxal phosphate-dependent ammonia lyase( domain architecture ID 10019051)

DgaE family pyridoxal phosphate-dependent ammonia lyase similar to Salmonella enterica D-glucosaminate-6-phosphate ammonia lyase (DgaE) that catalyzes the conversion of D-glucosaminate 6-phosphate to yield keto-3-deoxygluconate 6-phosphate (KDGP)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
selA_rel TIGR01437
uncharacterized pyridoxal phosphate-dependent enzyme; This model describes a protein related ...
 4-367 0e+00

uncharacterized pyridoxal phosphate-dependent enzyme; This model describes a protein related to a number of pyridoxal phosphate-dependent enzymes, and in particular to selenocysteine synthase (SelA), which converts Ser to selenocysteine on its tRNA. While resembling SelA, this protein is found only in species that have a better candidate SelA or else lack the other genes (selB, selC, and selD) required for selenocysteine incorporation. [Unknown function, Enzymes of unknown specificity]


:

Pssm-ID: 273623 [Multi-domain]  Cd Length: 363  Bit Score: 604.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277    4 IYEKYGLKQVINASGRMTILGVSTPAADVVDTVKYGLNHYFEIKDLVNKTGAYIASLLGCEDAVVVACASAGIAQSVAAV 83
Cdd:TIGR01437   1 IYEKYGLKKVINASGKMTILGVSTVSDEVADAQKRGAQNYFEIKELVNKTGEYIANLLGVEDAVIVSSASAGIAQSVAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   84 IVKDDDWLLENLHAAPLVVpHDIVVPKGHNVNFGAPVGTMVAMGGGRLIEAGYANECSADQLSAAVTPQTAAILYIKSHH 163
Cdd:TIGR01437  81 ITRGNRYLVENLHDSKIEV-NEVVLPKGHNVDYGAPVETMVRLGGGKVVEAGYANECSAEQLEAAITEKTAAILYIKSHH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  164 CVQKSHLSVEQAAVVARKHGVPLIVDAAAEEDLQCYYQDGADLVIYSGAKAIEGPTSGLVMGRKQYVEWVKRQSMGIGRA 243
Cdd:TIGR01437 160 CVQKSMLSVEDAAQVAQEHNLPLIVDAAAEEDLQKYYRLGADLVIYSGAKAIEGPTSGLVLGKKKYIEWVKLQSKGIGRA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  244 MKVGKEGILGLTQAIENYLVQEKVSGAQMVEKMTPFIDNLNALNGISARVVWDAAGRDIARAEIHFDEAVIGHTTGDVVQ 323
Cdd:TIGR01437 240 MKVGKENILGLTAALEQYLSTGKESGAEMVAKLTPFIEALNTLKGVSASIVQDEAGRDIARAEIRFDESELGMTAADVVQ 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 510817277  324 VLKTGEIAIYFRGYKANEGIVEVDVRSLTADQLNTIFVCIKALL 367
Cdd:TIGR01437 320 ALRQGEPAIYTRGYKANEGIIEIDPRSVTGGQLDIIVERIREIV 363
 
Name Accession Description Interval E-value
selA_rel TIGR01437
uncharacterized pyridoxal phosphate-dependent enzyme; This model describes a protein related ...
 4-367 0e+00

uncharacterized pyridoxal phosphate-dependent enzyme; This model describes a protein related to a number of pyridoxal phosphate-dependent enzymes, and in particular to selenocysteine synthase (SelA), which converts Ser to selenocysteine on its tRNA. While resembling SelA, this protein is found only in species that have a better candidate SelA or else lack the other genes (selB, selC, and selD) required for selenocysteine incorporation. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273623 [Multi-domain]  Cd Length: 363  Bit Score: 604.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277    4 IYEKYGLKQVINASGRMTILGVSTPAADVVDTVKYGLNHYFEIKDLVNKTGAYIASLLGCEDAVVVACASAGIAQSVAAV 83
Cdd:TIGR01437   1 IYEKYGLKKVINASGKMTILGVSTVSDEVADAQKRGAQNYFEIKELVNKTGEYIANLLGVEDAVIVSSASAGIAQSVAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   84 IVKDDDWLLENLHAAPLVVpHDIVVPKGHNVNFGAPVGTMVAMGGGRLIEAGYANECSADQLSAAVTPQTAAILYIKSHH 163
Cdd:TIGR01437  81 ITRGNRYLVENLHDSKIEV-NEVVLPKGHNVDYGAPVETMVRLGGGKVVEAGYANECSAEQLEAAITEKTAAILYIKSHH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  164 CVQKSHLSVEQAAVVARKHGVPLIVDAAAEEDLQCYYQDGADLVIYSGAKAIEGPTSGLVMGRKQYVEWVKRQSMGIGRA 243
Cdd:TIGR01437 160 CVQKSMLSVEDAAQVAQEHNLPLIVDAAAEEDLQKYYRLGADLVIYSGAKAIEGPTSGLVLGKKKYIEWVKLQSKGIGRA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  244 MKVGKEGILGLTQAIENYLVQEKVSGAQMVEKMTPFIDNLNALNGISARVVWDAAGRDIARAEIHFDEAVIGHTTGDVVQ 323
Cdd:TIGR01437 240 MKVGKENILGLTAALEQYLSTGKESGAEMVAKLTPFIEALNTLKGVSASIVQDEAGRDIARAEIRFDESELGMTAADVVQ 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 510817277  324 VLKTGEIAIYFRGYKANEGIVEVDVRSLTADQLNTIFVCIKALL 367
Cdd:TIGR01437 320 ALRQGEPAIYTRGYKANEGIIEIDPRSVTGGQLDIIVERIREIV 363
SelA COG1921
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
3-368 3.67e-116

Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441524  Cd Length: 399  Bit Score: 342.87  E-value: 3.67e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   3 SIYEKYGLKQVINASGRM--TILGVSTPAADVVDTVKYGLNHYFEIK---------DLVNKTGAYIASLLGCEDAVVVAC 71
Cdd:COG1921    9 SALERPGLRPVINATGTVlhTNLGRSPLSEEAVEAVAEAARGYSNLEydletgkrgSRYDHVEELLCELTGAEAALVVNN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  72 ASAGIAQSVAAVIVKDDdwllenlhaaplvvphdIVVPKGHNVNFGAP--VGTMVAMGGGRLIEAGYANECSADQLSAAV 149
Cdd:COG1921   89 NAAAVLLALAALAAGKE-----------------VIVSRGELVEIGGSfrIPDVMALSGAKLVEVGTTNRTHLRDYEAAI 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 150 TPQTAAILYIKSHHCVQK---SHLSVEQAAVVARKHGVPLIVDAAA-------------EEDLQCYYQDGADLVIYSGAK 213
Cdd:COG1921  152 TENTAALLKVHTSNYRIVgftEEVSLAELAELAHEHGLPVIVDLGSgslvdlskyglphEPTVQEYLAAGADLVTFSGDK 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 214 AIEGPTSGLVMGRKQYVEWVKRqsMGIGRAMKVGKEGILGLTQAIENYLVQEKV------------SGAQMVEKMTPFID 281
Cdd:COG1921  232 LLGGPQAGIIVGKKELIERIKK--NPLGRALRVDKETLAALEATLRLYLDPEKAaeeiptlrmltrPQEELRARAERLAE 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 282 NLNALNGISARVVWD--AAGR------DIARAEIHFDEAviGHTTGDVVQVLKTGEIAIYFRgykANEGIVEVDVRSLTA 353
Cdd:COG1921  310 ALNALLGVTVEIVPDesQVGGgslpveELPSAAVALDPA--GLSAEELAKALRRGDPPIIGR---IEDGRLLLDLRTLLP 384

                        410
                 ....*....|....*
gi 510817277 354 DQLNTIFVCIKALLS 368
Cdd:COG1921  385 DEEEIIAEALRELLA 399
SelA pfam03841
L-seryl-tRNA selenium transferase;
13-268 1.65e-17

L-seryl-tRNA selenium transferase;


Pssm-ID: 309101  Cd Length: 367  Bit Score: 82.77  E-value: 1.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   13 VINASGRM--TILGVSTPAADVVDTVKYGLNHYFEIK-DLVN-KTG---AYIASLL----GCEDAVVVAcasagiaQSVA 81
Cdd:pfam03841   1 VINATGVVlhTNLGRALLAEEAIEAALDAARRYSNLEyDLESgKRGsrdAHIEELLceltGAEDALVVN-------NNAA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   82 AVIvkdddwllenLHAAPLVVPHDIVVPKGHNVNFGAP--VGTMVAMGGGRLIEAGYANECSADQLSAAVTPQTAAILYI 159
Cdd:pfam03841  74 AVL----------LVLNTLAAGKEVIISRGELVEIGGSfrIPDVMKQAGVKLVEVGTTNRTHLKDYEQAINENTALLMKV 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  160 -KSHHCVQKSHLSVEQAAVV--ARKHGVPLIVDAA--AEEDLQCY-----------YQDGADLVIYSGAKAIEGPTSGLV 223
Cdd:pfam03841 144 hTSNYRIQGFTKEVELAELVelGHEKGLPVYEDLGsgSLVDLSQYglpkeptvqelIAQGVDLVSFSGDKLLGGPQAGII 223

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 510817277  224 MGRKQYVEWVKRQSmgIGRAMKVGKEGILGLTQAIENYLVQEKVS 268
Cdd:pfam03841 224 VGKKELIERIKKNP--LKRALRVDKLTLAALEATLRLYLDPEKLY 266
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
136-228 2.47e-06

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 48.93  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 136 YANECSADQLSAAVTPQTAAI-LYIKSHHCVQKShlSVEQAAVVARKHGVPLIVDAA-AEEDLQCYYQDGADLVIYSGAK 213
Cdd:PRK08247 120 YVNTASLKAIEQAITPNTKAIfIETPTNPLMQET--DIAAIAKIAKKHGLLLIVDNTfYTPVLQRPLEEGADIVIHSATK 197

                         90
                 ....*....|....*...
gi 510817277 214 AIEGPT---SGLVMGRKQ 228
Cdd:PRK08247 198 YLGGHNdvlAGLVVAKGQ 215
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 57-217 1.56e-03

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 40.26  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  57 IASLLGCEDAVVVACASAGIAqSVAAVIVKDDDwllenlHaapLVVPHDIVvpkGHNVNFGAPVgtMVAMGggrlIEAGY 136
Cdd:cd00614   49 LAALEGGEAALAFSSGMAAIS-TVLLALLKAGD------H---VVASDDLY---GGTYRLFERL--LPKLG----IEVTF 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 137 ANECSADQLSAAVTPQTAAIlYIKShhcVQKSHLSV---EQAAVVARKHGVPLIVDA--AAEedlqcYYQD----GADLV 207
Cdd:cd00614  110 VDPDDPEALEAAIKPETKLV-YVES---PTNPTLKVvdiEAIAELAHEHGALLVVDNtfATP-----YLQRplelGADIV 180

                        170
                 ....*....|
gi 510817277 208 IYSGAKAIEG 217
Cdd:cd00614  181 VHSATKYIGG 190
 
Name Accession Description Interval E-value
selA_rel TIGR01437
uncharacterized pyridoxal phosphate-dependent enzyme; This model describes a protein related ...
 4-367 0e+00

uncharacterized pyridoxal phosphate-dependent enzyme; This model describes a protein related to a number of pyridoxal phosphate-dependent enzymes, and in particular to selenocysteine synthase (SelA), which converts Ser to selenocysteine on its tRNA. While resembling SelA, this protein is found only in species that have a better candidate SelA or else lack the other genes (selB, selC, and selD) required for selenocysteine incorporation. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 273623 [Multi-domain]  Cd Length: 363  Bit Score: 604.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277    4 IYEKYGLKQVINASGRMTILGVSTPAADVVDTVKYGLNHYFEIKDLVNKTGAYIASLLGCEDAVVVACASAGIAQSVAAV 83
Cdd:TIGR01437   1 IYEKYGLKKVINASGKMTILGVSTVSDEVADAQKRGAQNYFEIKELVNKTGEYIANLLGVEDAVIVSSASAGIAQSVAAV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   84 IVKDDDWLLENLHAAPLVVpHDIVVPKGHNVNFGAPVGTMVAMGGGRLIEAGYANECSADQLSAAVTPQTAAILYIKSHH 163
Cdd:TIGR01437  81 ITRGNRYLVENLHDSKIEV-NEVVLPKGHNVDYGAPVETMVRLGGGKVVEAGYANECSAEQLEAAITEKTAAILYIKSHH 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  164 CVQKSHLSVEQAAVVARKHGVPLIVDAAAEEDLQCYYQDGADLVIYSGAKAIEGPTSGLVMGRKQYVEWVKRQSMGIGRA 243
Cdd:TIGR01437 160 CVQKSMLSVEDAAQVAQEHNLPLIVDAAAEEDLQKYYRLGADLVIYSGAKAIEGPTSGLVLGKKKYIEWVKLQSKGIGRA 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  244 MKVGKEGILGLTQAIENYLVQEKVSGAQMVEKMTPFIDNLNALNGISARVVWDAAGRDIARAEIHFDEAVIGHTTGDVVQ 323
Cdd:TIGR01437 240 MKVGKENILGLTAALEQYLSTGKESGAEMVAKLTPFIEALNTLKGVSASIVQDEAGRDIARAEIRFDESELGMTAADVVQ 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 510817277  324 VLKTGEIAIYFRGYKANEGIVEVDVRSLTADQLNTIFVCIKALL 367
Cdd:TIGR01437 320 ALRQGEPAIYTRGYKANEGIIEIDPRSVTGGQLDIIVERIREIV 363
SelA COG1921
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
3-368 3.67e-116

Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441524  Cd Length: 399  Bit Score: 342.87  E-value: 3.67e-116
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   3 SIYEKYGLKQVINASGRM--TILGVSTPAADVVDTVKYGLNHYFEIK---------DLVNKTGAYIASLLGCEDAVVVAC 71
Cdd:COG1921    9 SALERPGLRPVINATGTVlhTNLGRSPLSEEAVEAVAEAARGYSNLEydletgkrgSRYDHVEELLCELTGAEAALVVNN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  72 ASAGIAQSVAAVIVKDDdwllenlhaaplvvphdIVVPKGHNVNFGAP--VGTMVAMGGGRLIEAGYANECSADQLSAAV 149
Cdd:COG1921   89 NAAAVLLALAALAAGKE-----------------VIVSRGELVEIGGSfrIPDVMALSGAKLVEVGTTNRTHLRDYEAAI 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 150 TPQTAAILYIKSHHCVQK---SHLSVEQAAVVARKHGVPLIVDAAA-------------EEDLQCYYQDGADLVIYSGAK 213
Cdd:COG1921  152 TENTAALLKVHTSNYRIVgftEEVSLAELAELAHEHGLPVIVDLGSgslvdlskyglphEPTVQEYLAAGADLVTFSGDK 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 214 AIEGPTSGLVMGRKQYVEWVKRqsMGIGRAMKVGKEGILGLTQAIENYLVQEKV------------SGAQMVEKMTPFID 281
Cdd:COG1921  232 LLGGPQAGIIVGKKELIERIKK--NPLGRALRVDKETLAALEATLRLYLDPEKAaeeiptlrmltrPQEELRARAERLAE 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 282 NLNALNGISARVVWD--AAGR------DIARAEIHFDEAviGHTTGDVVQVLKTGEIAIYFRgykANEGIVEVDVRSLTA 353
Cdd:COG1921  310 ALNALLGVTVEIVPDesQVGGgslpveELPSAAVALDPA--GLSAEELAKALRRGDPPIIGR---IEDGRLLLDLRTLLP 384

                        410
                 ....*....|....*
gi 510817277 354 DQLNTIFVCIKALLS 368
Cdd:COG1921  385 DEEEIIAEALRELLA 399
SelA pfam03841
L-seryl-tRNA selenium transferase;
13-268 1.65e-17

L-seryl-tRNA selenium transferase;


Pssm-ID: 309101  Cd Length: 367  Bit Score: 82.77  E-value: 1.65e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   13 VINASGRM--TILGVSTPAADVVDTVKYGLNHYFEIK-DLVN-KTG---AYIASLL----GCEDAVVVAcasagiaQSVA 81
Cdd:pfam03841   1 VINATGVVlhTNLGRALLAEEAIEAALDAARRYSNLEyDLESgKRGsrdAHIEELLceltGAEDALVVN-------NNAA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   82 AVIvkdddwllenLHAAPLVVPHDIVVPKGHNVNFGAP--VGTMVAMGGGRLIEAGYANECSADQLSAAVTPQTAAILYI 159
Cdd:pfam03841  74 AVL----------LVLNTLAAGKEVIISRGELVEIGGSfrIPDVMKQAGVKLVEVGTTNRTHLKDYEQAINENTALLMKV 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  160 -KSHHCVQKSHLSVEQAAVV--ARKHGVPLIVDAA--AEEDLQCY-----------YQDGADLVIYSGAKAIEGPTSGLV 223
Cdd:pfam03841 144 hTSNYRIQGFTKEVELAELVelGHEKGLPVYEDLGsgSLVDLSQYglpkeptvqelIAQGVDLVSFSGDKLLGGPQAGII 223

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 510817277  224 MGRKQYVEWVKRQSmgIGRAMKVGKEGILGLTQAIENYLVQEKVS 268
Cdd:pfam03841 224 VGKKELIERIKKNP--LKRALRVDKLTLAALEATLRLYLDPEKLY 266
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
136-228 2.47e-06

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 48.93  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 136 YANECSADQLSAAVTPQTAAI-LYIKSHHCVQKShlSVEQAAVVARKHGVPLIVDAA-AEEDLQCYYQDGADLVIYSGAK 213
Cdd:PRK08247 120 YVNTASLKAIEQAITPNTKAIfIETPTNPLMQET--DIAAIAKIAKKHGLLLIVDNTfYTPVLQRPLEEGADIVIHSATK 197

                         90
                 ....*....|....*...
gi 510817277 214 AIEGPT---SGLVMGRKQ 228
Cdd:PRK08247 198 YLGGHNdvlAGLVVAKGQ 215
PRK05994 PRK05994
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 147-217 2.30e-05

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 180344 [Multi-domain]  Cd Length: 427  Bit Score: 46.24  E-value: 2.30e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 510817277 147 AAVTPQTAAIlYIKSHHCVQKSHLSVEQAAVVARKHGVPLIVD-AAAEEDLQCYYQDGADLVIYSGAKAIEG 217
Cdd:PRK05994 143 RAITPRTKAI-FIESIANPGGTVTDIAAIAEVAHRAGLPLIVDnTLASPYLIRPIEHGADIVVHSLTKFLGG 213
PRK08248 PRK08248
homocysteine synthase;
143-217 7.17e-04

homocysteine synthase;


Pssm-ID: 236201 [Multi-domain]  Cd Length: 431  Bit Score: 41.37  E-value: 7.17e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 510817277 143 DQLSAAVTPQTAAIlYIKSHHCVQKSHLSVEQAAVVARKHGVPLIVDAAAEEDLQCY-YQDGADLVIYSGAKAIEG 217
Cdd:PRK08248 140 ENFEAAITDKTKAL-FAETIGNPKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRpIEHGADIVVHSATKFIGG 214
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 57-217 1.56e-03

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 40.26  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  57 IASLLGCEDAVVVACASAGIAqSVAAVIVKDDDwllenlHaapLVVPHDIVvpkGHNVNFGAPVgtMVAMGggrlIEAGY 136
Cdd:cd00614   49 LAALEGGEAALAFSSGMAAIS-TVLLALLKAGD------H---VVASDDLY---GGTYRLFERL--LPKLG----IEVTF 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 137 ANECSADQLSAAVTPQTAAIlYIKShhcVQKSHLSV---EQAAVVARKHGVPLIVDA--AAEedlqcYYQD----GADLV 207
Cdd:cd00614  110 VDPDDPEALEAAIKPETKLV-YVES---PTNPTLKVvdiEAIAELAHEHGALLVVDNtfATP-----YLQRplelGADIV 180

                        170
                 ....*....|
gi 510817277 208 IYSGAKAIEG 217
Cdd:cd00614  181 VHSATKYIGG 190
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 57-217 2.05e-03

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 39.91  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277   57 IASLLGCEDAVVVACASAGIAQSVAAVIVKDDDWllenlhaaplVVPHDI----------VVPKGHnvnfgapvgtmvam 126
Cdd:pfam01053  56 IAALEGGAAALAFSSGMAAITAAILALLKAGDHI----------VATDDLyggtyrlfnkVLPRFG-------------- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277  127 gggrlIEAGYANECSADQLSAAVTPQTAAIlYIKSHHCVQKSHLSVEQAAVVARKHGVPLIVDAA-AEEDLQCYYQDGAD 205
Cdd:pfam01053 112 -----IEVTFVDTSDPEDLEAAIKPNTKAV-YLETPTNPLLKVVDIEAIAKLAKKHGILVVVDNTfASPYLQRPLDLGAD 185

                         170
                  ....*....|..
gi 510817277  206 LVIYSGAKAIEG 217
Cdd:pfam01053 186 IVVHSATKYIGG 197
PRK07812 PRK07812
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 143-217 2.18e-03

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 236105  Cd Length: 436  Bit Score: 39.73  E-value: 2.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 510817277 143 DQLSAAVTPQTAAiLYIKSHHCVQKSHLSVEQAAVVARKHGVPLIVD-AAAEEDLQCYYQDGADLVIYSGAKAIEG 217
Cdd:PRK07812 146 DAWRAAVRPNTKA-FFAETISNPQIDVLDIPGVAEVAHEAGVPLIVDnTIATPYLIRPLEHGADIVVHSATKYLGG 220
MET17 COG2873
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ...
 132-225 2.38e-03

O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 442120 [Multi-domain]  Cd Length: 428  Bit Score: 39.63  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 132 IEAGYANECSADQLSAAVTPQTAAIlYIKShhcvqkshLS--------VEQAAVVARKHGVPLIVD---AAAeedlqcyY 200
Cdd:COG2873  128 IEVRFVDPDDPEAFEAAIDPNTKAI-FGET--------IGnpaldvldIEAIAEIAHEHGVPLIVDntfATP-------Y 191

                         90       100       110
                 ....*....|....*....|....*....|
gi 510817277 201 -----QDGADLVIYSGAKAIEGptSGLVMG 225
Cdd:COG2873  192 lcrpiEHGADIVVHSATKYIGG--HGTSIG 219
PRK06176 PRK06176
cystathionine gamma-synthase;
144-223 2.79e-03

cystathionine gamma-synthase;


Pssm-ID: 180443 [Multi-domain]  Cd Length: 380  Bit Score: 39.50  E-value: 2.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 144 QLSAAVTPQTAAiLYIKSHHCVQKSHLSVEQAAVVARKHGVPLIVDAAAEEDlqcYYQD----GADLVIYSGAKAIEGPT 219
Cdd:PRK06176 126 QIKKAIKPNTKA-LYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATP---YYQNplllGADIVVHSGTKYLGGHS 201


                 ....*..
gi 510817277 220 ---SGLV 223
Cdd:PRK06176 202 dvvAGLV 208
PRK06084 PRK06084
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
132-217 5.78e-03

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 180392 [Multi-domain]  Cd Length: 425  Bit Score: 38.34  E-value: 5.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510817277 132 IEAGYANECSADQLSAAVTPQTAAIlYIKSHHCVQKSHLSVEQAAVVARKHGVPLIVDAAAEEDLQCY-YQDGADLVIYS 210
Cdd:PRK06084 123 IETRFAAHDDIAALEALIDERTKAV-FCESIGNPAGNIIDIQALADAAHRHGVPLIVDNTVATPVLCRpFEHGADIVVHS 201


                 ....*..
gi 510817277 211 GAKAIEG 217
Cdd:PRK06084 202 LTKYIGG 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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