|
Name |
Accession |
Description |
Interval |
E-value |
| RHS_core |
NF041261 |
RHS element core protein; |
1-1258 |
0e+00 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 2622.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1 MIGKPAARQGDMTQYGGPIVQGSAGVRIGAPTGVACSVCPGGMTSGNPVNPLLGAKVLPGETDLALPGPLPFILSRTYSS 80
Cdd:NF041261 1 MSGKPAARQGDMTQYGGPIVQGSAGVRIGAPTGVACSVCPGGMTSGNPVNPLLGAKVLPGETDIALPGPLPFILSRTYSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 81 YRTRTPAPVGVFGPGWKAPSDIRLQLRDDALVLNDNGGRSIHFEPLLPGEAVYSRSESMWLVRGGKAAQPDGHTLARLWG 160
Cdd:NF041261 81 YRTRTPAPVGVFGPGWKAPSDIRLQLRDDGLILNDNGGRSIHFEPLFPGEAVYSRSESLWLVRGGVAAQPDGHTLAALWQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 161 ALPPDIRLSPHLYLATNSAQGPWWILGWSERVPGAEDVLPAPLPPYRVLTGMADRFGRTLTYRREAAGDLAGEITGVTDG 240
Cdd:NF041261 161 ALPEDIRLSPHLYLATNSAQGPWWILGWSERVPGADEVLPAPLPPYRVLTGMVDRFGRTLTFHREAAGDLAGEITGVTDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 241 AGREFRLVLTTQAQRAEEAR---TSSLSSSDSSRPLSASAFPDTLPG-TEYGPDRGIRLSAVWLMHDPAYPESLPAAPLV 316
Cdd:NF041261 241 AGREFRLVLTTQAQRAEEARkqrTSSLSSPDGPRPLSSSAFPDTLPGgTEYGPDNGIRLSAVWLTHDPAYPESLPAAPLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 317 RYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRYAGRPEMRYRYDDTGRVVEQLNPAGLSYRYLYEQDRITVTDS 396
Cdd:NF041261 321 RYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQDRITITDS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 397 LNRREVLHTEGGAGLKRVVKKELADGSVTRSGYDAAGRLTAQTDAAGRRTEYGLNVVSGDITDITTPDGRETKFYYNDGN 476
Cdd:NF041261 401 LNRREVLHTEGEGGLKRVVKKEHADGSVTRSGYDAAGRLTAQTDAAGRRTEYSLNVVSGDITDITTPDGRETKFYYNDGN 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 477 QLTAVVSPDGLESRREYDEPGRLVSETSRSGETVRYRYDDAHSELPATTTDATGSTRQMTWSRYGQLLAFTDCSGYQTRY 556
Cdd:NF041261 481 QLTSVTSPDGLESRREYDEPGRLVSETSRSGETTRYRYDDPHSELPATTTDATGSTKQMTWSRYGQLLAFTDCSGYQTRY 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 557 EYDRFGQMTAVHREEGISLYRRYDNRGRLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQGGLT 636
Cdd:NF041261 561 EYDRFGQMTAVHREEGISTYRRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQGGLT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 637 RSMEYDAAGRVISLTNENGSHSVFSYDALDRLVQQGGFDGRTQRYHYDLTGKLTQSEDEGLVILWYYDESDRITHRTVNG 716
Cdd:NF041261 641 RSMEYDAAGRITTLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGKLTQSEDEGLVTLWHYDESDRITHRTVNG 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 717 EPAEQWQYDGHGWLTDISHLSEGHRVAVHYGYDDKGRLTGERQTVENPETGELLWHHETGHAYNEQGLANRVTPDSLPPV 796
Cdd:NF041261 721 EPAEQWQYDEHGWLTDISHLSEGHRVAVHYGYDDKGRLTGERQTVENPETGELLWQHETGHAYNEQGLANRVTPDSLPPV 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 797 EWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFGsMAGSNAAYELTSTYTPAGQLQSQHLNSLVYDRDYGWNDNGDL 876
Cdd:NF041261 801 EWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFG-GAGSNAAYELTTAYTPAGQLQSQHLNSLVYDRDYTWNDNGDL 879
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 877 VRISGPRQTREYGYSATGRLESVRTLAPDLDIRIPYATDPAGNRLPDPELHPDSTLTVWPDNRIAEDAHYVYRHDEYGRL 956
Cdd:NF041261 880 VRISGPRQTREYGYSATGRLTGVHTTAANLDIRIPYATDPAGNRLPDPELHPDSTLTAWPDNRIAEDAHYVYRYDEYGRL 959
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 957 TEKTDRIPAGVIRTDDERTHHYHYDSQHRLVFYTRIQHGEPLVESRYLYDPLGRRMAKRVWRRERDLTGWMSLSRKPEVT 1036
Cdd:NF041261 960 TEKTDRIPEGVIRTDDERTHHYHYDSQHRLVFYTRIQHGEPLVESRYLYDPLGRRMAKRVWRRERDLTGWMSLSRKPEVT 1039
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1037 WYGWDGDRLTTVQTDTTRIQTVYEPGSFTPLIRVETENGEREKAQRRSLAETLQQEGSENGHGVVFPAELVRLLDRLEEE 1116
Cdd:NF041261 1040 WYGWDGDRLTTVQTDTTRIQTVYQPGSFTPLIRVETENGERAKAQRRSLAETLQQEGSENGHGVVFPAELVRMLDRLEEE 1119
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1117 IRADRVSSESRAWLAQCGLTVEQLARQVEPEYTPARKAHLYHCDHRGLPLALISEDGNTAWSAEYDEWGNQLNEENPHHV 1196
Cdd:NF041261 1120 IRADRVSEESRAWLAQCGLTVEQMARQVEPEYTPARKLHLYHCDHRGLPLALISEEGNTAWQGEYDEWGNLLNEENPHHL 1199
|
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 510927607 1197 YQPYCLPGQQHDEESGLYYNRHRYYDPLQGRYITQDPMGLKGGWNLYQYPLNPLQQIDPMGL 1258
Cdd:NF041261 1200 QQPYRLPGQQYDEESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
|
|
| DUF4329 |
pfam14220 |
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found ... |
1292-1409 |
1.27e-38 |
|
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with pfam05593 and pfam03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.
Pssm-ID: 433783 Cd Length: 114 Bit Score: 139.82 E-value: 1.27e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1292 DAALDALKETQNRSLCNDMEYSGIVCKDTNGKYFASkAETDNLRKESypLKRKCPTGTDRVAAYHTHGADSHgDYVDEFF 1371
Cdd:pfam14220 1 DAAKDALEEYNGRSIRENREYCGFILTDDEGKYVYT-APTRGGEASS--GNPPVPNGQTVVASYHTHGAYDS-NYDSEVF 76
|
90 100 110
....*....|....*....|....*....|....*...
gi 510927607 1372 SSSDKNLVRSKDNNLEAFYLATPDGRFEALNNKGEYIF 1409
Cdd:pfam14220 77 SVQDKKIVLSDMQNGVNGYVATPGGRLWYIDPSRSYAR 114
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
151-1297 |
3.57e-29 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 126.79 E-value: 3.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 151 DGHTLARLWGALPPDIRLSPHLYLATNSAQGPWWILGWSERVPGAEDVLPAPLPPYRVLTGMADRFGRTLTYRREAAGDL 230
Cdd:COG3209 33 GSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDASAAGGGYVGGAAAGGGATLTGLAAAT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 231 AGEITGVTDGAGREFRLVLTTQAQRAEEARTSSLSSSDSSRPLSASAFPDTLPGTEYGPDRGIRLSAVWLMHDPAYPESL 310
Cdd:COG3209 113 ASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 311 PAAPLVRYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRyagrpemRYRYDDTGRVVEQLNPAGLSYRYLYEQDR 390
Cdd:COG3209 193 TGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAA-------TVTGSATGAAGAGAAVATAATTLGGTTGA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 391 ITVTDSLNRREVLHTEGGAGLKRVVKKELADGSVTRSGYDAAGRLTAQTDAAGRRTEYGLNVVSGDITDITTPDGRETKF 470
Cdd:COG3209 266 GTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGT 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 471 YYNDGNQLTAVVSPDGLESRREYDEPGRLVSETSRSGETVRYRYDDAHSELPATTTDATGSTRQMTWSRYGQLLAFTDCS 550
Cdd:COG3209 346 TTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGA 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 551 GYQTRYEYDRFGQMTAVHREEGISLYRRYDNRGRLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVST 630
Cdd:COG3209 426 LTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDT 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 631 TQGGLTRSMEYDAAGRVISLTNENGSHSVFSYDALDRLVQQGGFDGRTQRYHYDLTGKLTQSEDEGLVILWYYDESDRIT 710
Cdd:COG3209 506 LGGTTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTT 585
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 711 HRTVNGEPAEQWQYDGHGWLTDISHLSEGHRVAVHYGYDDKGRLTGERQTVENPETGELLWHHETGHAYNEQGLANRVTP 790
Cdd:COG3209 586 GGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGT 665
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 791 DSLPPVEWLTYGSGYLAGmklGGTPLVEYTRDRLHRETVRSFGSMAGSNAAYELTSTYTPAGQLQSQHLNSLVYDRDYGW 870
Cdd:COG3209 666 GTGVTAGLTTLATGGTTV---GGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTG 742
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 871 NDNGDLVRISGPRQTREYGYSATGRLESVRT--LAPDLDIRIPYATDPAGNRlpdpelhpdsTLTVWPDNRIAEdahyvY 948
Cdd:COG3209 743 TLTTTSTTTTTTAGALTYTYDALGRLTSETTpgGVTQGTYTTRYTYDALGRL----------TSVTYPDGETVT-----Y 807
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 949 RHDEYGRLTEKtdrIPAGVIRTDDERTHHYHYDSQHRLVFYTRIQHGEPLVEsRYLYDPLGR-RMAKRVWRRER---DLT 1024
Cdd:COG3209 808 TYDALGRLTSV---ITVGSGGGTDLQDRTYTYDAAGNITSITDALRAGTLTQ-TYTYDALGRlTSATDPGTTESytyDAN 883
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1025 GWMSLSRKPEVTWYGWDG-DRLTTVQT-DTTRIQTVYEPgsftplirvetengerekaqrrslaetlqqegsenghgvvf 1102
Cdd:COG3209 884 GNLTSRTDGGTTTYTYDAlGRLVSVTKpDGTTTTYTYDA----------------------------------------- 922
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1103 paelvrlldrleeeiradrvssesrawlaqcgltveqlarqvepeytparkahLYHCDHRGLPLALISEDGNTAWSAEYD 1182
Cdd:COG3209 923 -----------------------------------------------------LGHTDHLGSVRALTDASGQVVWRYDYD 949
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1183 EWGNQLNEENPHhVYQPYCLPGQQHDEESGLYYNRHRYYDPLQGRYITQDPMGLKGGWNLYQYPL-NPLQQIDPMGLLQT 1261
Cdd:COG3209 950 PFGNLLAETSGA-AANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGLAGGLNLYAYVGnNPVNYVDPLGLAAL 1028
|
1130 1140 1150
....*....|....*....|....*....|....*.
gi 510927607 1262 WDDARSGACTGGVCGVLSRIIGPSKFDSTADAALDA 1297
Cdd:COG3209 1029 LGTTGLGGGAGVGAGAAGGGAAAAGGSAGAGAAGGG 1064
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
1181-1258 |
5.79e-28 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 107.97 E-value: 5.79e-28
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 510927607 1181 YDEWGNQLNEENphHVYQPYCLPGQQHDEESGLYYNRHRYYDPLQGRYITQDPMGLKGGWNLYQY-PLNPLQQIDPMGL 1258
Cdd:TIGR03696 1 YDPYGEVLSESG--AAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYvGNNPVNWVDPLGL 77
|
|
| DUF6531 |
pfam20148 |
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins. |
46-123 |
6.20e-19 |
|
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.
Pssm-ID: 466309 [Multi-domain] Cd Length: 74 Bit Score: 82.19 E-value: 6.20e-19
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 510927607 46 GNPVNPLLGAKVLPgETDLALPGPLPFILSRTYSSYRTRTpapvGVFGPGWKAPSDIRLQLRDD-ALVLNDNGGRSIHF 123
Cdd:pfam20148 1 GDPVNVATGNKVLE-ETDFSLPGPLPLVWTRTYNSSSERD----GPLGPGWSHPYDQRLELEGDgGVVYIDADGREVTF 74
|
|
| PAAR_2 |
cd14738 |
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR ... |
3-29 |
8.70e-08 |
|
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat family, where it forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). The T6SS is responsible for translocation of a wide variety of toxic effector molecules, allowing predatory cells to kill prokaryotic as well as eukaryotic prey cells. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes. It has been shown that PAAR proteins are essential for T6SS-mediated secretion and target cell killing by Vibrio cholerae (encodes two PAAR proteins) and Acinetobacter baylyi (encodes three PAAR proteins); inactivation of all these PAAR genes results in inactivation of Hcp secretion as well as T6SS-dependent killing of E. coli.
Pssm-ID: 269823 Cd Length: 94 Bit Score: 51.09 E-value: 8.70e-08
10 20
....*....|....*....|....*..
gi 510927607 3 GKPAARQGDMTQYGGPIVQGSAGVRIG 29
Cdd:cd14738 68 GKPAARMGDSTAHGGVIVSGVPTVLIG 94
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RHS_core |
NF041261 |
RHS element core protein; |
1-1258 |
0e+00 |
|
RHS element core protein;
Pssm-ID: 469161 [Multi-domain] Cd Length: 1261 Bit Score: 2622.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1 MIGKPAARQGDMTQYGGPIVQGSAGVRIGAPTGVACSVCPGGMTSGNPVNPLLGAKVLPGETDLALPGPLPFILSRTYSS 80
Cdd:NF041261 1 MSGKPAARQGDMTQYGGPIVQGSAGVRIGAPTGVACSVCPGGMTSGNPVNPLLGAKVLPGETDIALPGPLPFILSRTYSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 81 YRTRTPAPVGVFGPGWKAPSDIRLQLRDDALVLNDNGGRSIHFEPLLPGEAVYSRSESMWLVRGGKAAQPDGHTLARLWG 160
Cdd:NF041261 81 YRTRTPAPVGVFGPGWKAPSDIRLQLRDDGLILNDNGGRSIHFEPLFPGEAVYSRSESLWLVRGGVAAQPDGHTLAALWQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 161 ALPPDIRLSPHLYLATNSAQGPWWILGWSERVPGAEDVLPAPLPPYRVLTGMADRFGRTLTYRREAAGDLAGEITGVTDG 240
Cdd:NF041261 161 ALPEDIRLSPHLYLATNSAQGPWWILGWSERVPGADEVLPAPLPPYRVLTGMVDRFGRTLTFHREAAGDLAGEITGVTDG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 241 AGREFRLVLTTQAQRAEEAR---TSSLSSSDSSRPLSASAFPDTLPG-TEYGPDRGIRLSAVWLMHDPAYPESLPAAPLV 316
Cdd:NF041261 241 AGREFRLVLTTQAQRAEEARkqrTSSLSSPDGPRPLSSSAFPDTLPGgTEYGPDNGIRLSAVWLTHDPAYPESLPAAPLV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 317 RYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRYAGRPEMRYRYDDTGRVVEQLNPAGLSYRYLYEQDRITVTDS 396
Cdd:NF041261 321 RYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRYAGRPEMCYRYDDTGRVTEQLNPAGLSYRYQYEQDRITITDS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 397 LNRREVLHTEGGAGLKRVVKKELADGSVTRSGYDAAGRLTAQTDAAGRRTEYGLNVVSGDITDITTPDGRETKFYYNDGN 476
Cdd:NF041261 401 LNRREVLHTEGEGGLKRVVKKEHADGSVTRSGYDAAGRLTAQTDAAGRRTEYSLNVVSGDITDITTPDGRETKFYYNDGN 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 477 QLTAVVSPDGLESRREYDEPGRLVSETSRSGETVRYRYDDAHSELPATTTDATGSTRQMTWSRYGQLLAFTDCSGYQTRY 556
Cdd:NF041261 481 QLTSVTSPDGLESRREYDEPGRLVSETSRSGETTRYRYDDPHSELPATTTDATGSTKQMTWSRYGQLLAFTDCSGYQTRY 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 557 EYDRFGQMTAVHREEGISLYRRYDNRGRLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQGGLT 636
Cdd:NF041261 561 EYDRFGQMTAVHREEGISTYRRYDNRGQLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVSTTQGGLT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 637 RSMEYDAAGRVISLTNENGSHSVFSYDALDRLVQQGGFDGRTQRYHYDLTGKLTQSEDEGLVILWYYDESDRITHRTVNG 716
Cdd:NF041261 641 RSMEYDAAGRITTLTNENGSHSTFLYDALDRLVQQRGFDGRTQRYHYDLTGKLTQSEDEGLVTLWHYDESDRITHRTVNG 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 717 EPAEQWQYDGHGWLTDISHLSEGHRVAVHYGYDDKGRLTGERQTVENPETGELLWHHETGHAYNEQGLANRVTPDSLPPV 796
Cdd:NF041261 721 EPAEQWQYDEHGWLTDISHLSEGHRVAVHYGYDDKGRLTGERQTVENPETGELLWQHETGHAYNEQGLANRVTPDSLPPV 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 797 EWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFGsMAGSNAAYELTSTYTPAGQLQSQHLNSLVYDRDYGWNDNGDL 876
Cdd:NF041261 801 EWLTYGSGYLAGMKLGGTPLVEYTRDRLHRETVRSFG-GAGSNAAYELTTAYTPAGQLQSQHLNSLVYDRDYTWNDNGDL 879
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 877 VRISGPRQTREYGYSATGRLESVRTLAPDLDIRIPYATDPAGNRLPDPELHPDSTLTVWPDNRIAEDAHYVYRHDEYGRL 956
Cdd:NF041261 880 VRISGPRQTREYGYSATGRLTGVHTTAANLDIRIPYATDPAGNRLPDPELHPDSTLTAWPDNRIAEDAHYVYRYDEYGRL 959
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 957 TEKTDRIPAGVIRTDDERTHHYHYDSQHRLVFYTRIQHGEPLVESRYLYDPLGRRMAKRVWRRERDLTGWMSLSRKPEVT 1036
Cdd:NF041261 960 TEKTDRIPEGVIRTDDERTHHYHYDSQHRLVFYTRIQHGEPLVESRYLYDPLGRRMAKRVWRRERDLTGWMSLSRKPEVT 1039
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1037 WYGWDGDRLTTVQTDTTRIQTVYEPGSFTPLIRVETENGEREKAQRRSLAETLQQEGSENGHGVVFPAELVRLLDRLEEE 1116
Cdd:NF041261 1040 WYGWDGDRLTTVQTDTTRIQTVYQPGSFTPLIRVETENGERAKAQRRSLAETLQQEGSENGHGVVFPAELVRMLDRLEEE 1119
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1117 IRADRVSSESRAWLAQCGLTVEQLARQVEPEYTPARKAHLYHCDHRGLPLALISEDGNTAWSAEYDEWGNQLNEENPHHV 1196
Cdd:NF041261 1120 IRADRVSEESRAWLAQCGLTVEQMARQVEPEYTPARKLHLYHCDHRGLPLALISEEGNTAWQGEYDEWGNLLNEENPHHL 1199
|
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 510927607 1197 YQPYCLPGQQHDEESGLYYNRHRYYDPLQGRYITQDPMGLKGGWNLYQYPLNPLQQIDPMGL 1258
Cdd:NF041261 1200 QQPYRLPGQQYDEESGLYYNRNRYYDPLQGRYITQDPIGLKGGWNLYQYPLNPIRFIDPLGL 1261
|
|
| DUF4329 |
pfam14220 |
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found ... |
1292-1409 |
1.27e-38 |
|
Domain of unknown function (DUF4329); This domain is functionally uncharacterized. It is found in bacteria and eukaryotes, and is approximately 130 amino acids in length. It is often found in association with pfam05593 and pfam03527. There is a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.
Pssm-ID: 433783 Cd Length: 114 Bit Score: 139.82 E-value: 1.27e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1292 DAALDALKETQNRSLCNDMEYSGIVCKDTNGKYFASkAETDNLRKESypLKRKCPTGTDRVAAYHTHGADSHgDYVDEFF 1371
Cdd:pfam14220 1 DAAKDALEEYNGRSIRENREYCGFILTDDEGKYVYT-APTRGGEASS--GNPPVPNGQTVVASYHTHGAYDS-NYDSEVF 76
|
90 100 110
....*....|....*....|....*....|....*...
gi 510927607 1372 SSSDKNLVRSKDNNLEAFYLATPDGRFEALNNKGEYIF 1409
Cdd:pfam14220 77 SVQDKKIVLSDMQNGVNGYVATPGGRLWYIDPSRSYAR 114
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
151-1297 |
3.57e-29 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 126.79 E-value: 3.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 151 DGHTLARLWGALPPDIRLSPHLYLATNSAQGPWWILGWSERVPGAEDVLPAPLPPYRVLTGMADRFGRTLTYRREAAGDL 230
Cdd:COG3209 33 GSTVLLAKGGLSTAAAAGGAATLTARSASTTDVVGTLTGAGGTSAGGVTALGDASAAGGGYVGGAAAGGGATLTGLAAAT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 231 AGEITGVTDGAGREFRLVLTTQAQRAEEARTSSLSSSDSSRPLSASAFPDTLPGTEYGPDRGIRLSAVWLMHDPAYPESL 310
Cdd:COG3209 113 ASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGAVTLA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 311 PAAPLVRYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRyagrpemRYRYDDTGRVVEQLNPAGLSYRYLYEQDR 390
Cdd:COG3209 193 TGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAA-------TVTGSATGAAGAGAAVATAATTLGGTTGA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 391 ITVTDSLNRREVLHTEGGAGLKRVVKKELADGSVTRSGYDAAGRLTAQTDAAGRRTEYGLNVVSGDITDITTPDGRETKF 470
Cdd:COG3209 266 GTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGT 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 471 YYNDGNQLTAVVSPDGLESRREYDEPGRLVSETSRSGETVRYRYDDAHSELPATTTDATGSTRQMTWSRYGQLLAFTDCS 550
Cdd:COG3209 346 TTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGA 425
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 551 GYQTRYEYDRFGQMTAVHREEGISLYRRYDNRGRLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQYDAWGKAVST 630
Cdd:COG3209 426 LTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDT 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 631 TQGGLTRSMEYDAAGRVISLTNENGSHSVFSYDALDRLVQQGGFDGRTQRYHYDLTGKLTQSEDEGLVILWYYDESDRIT 710
Cdd:COG3209 506 LGGTTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTT 585
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 711 HRTVNGEPAEQWQYDGHGWLTDISHLSEGHRVAVHYGYDDKGRLTGERQTVENPETGELLWHHETGHAYNEQGLANRVTP 790
Cdd:COG3209 586 GGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRATGTTGT 665
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 791 DSLPPVEWLTYGSGYLAGmklGGTPLVEYTRDRLHRETVRSFGSMAGSNAAYELTSTYTPAGQLQSQHLNSLVYDRDYGW 870
Cdd:COG3209 666 GTGVTAGLTTLATGGTTV---GGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTG 742
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 871 NDNGDLVRISGPRQTREYGYSATGRLESVRT--LAPDLDIRIPYATDPAGNRlpdpelhpdsTLTVWPDNRIAEdahyvY 948
Cdd:COG3209 743 TLTTTSTTTTTTAGALTYTYDALGRLTSETTpgGVTQGTYTTRYTYDALGRL----------TSVTYPDGETVT-----Y 807
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 949 RHDEYGRLTEKtdrIPAGVIRTDDERTHHYHYDSQHRLVFYTRIQHGEPLVEsRYLYDPLGR-RMAKRVWRRER---DLT 1024
Cdd:COG3209 808 TYDALGRLTSV---ITVGSGGGTDLQDRTYTYDAAGNITSITDALRAGTLTQ-TYTYDALGRlTSATDPGTTESytyDAN 883
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1025 GWMSLSRKPEVTWYGWDG-DRLTTVQT-DTTRIQTVYEPgsftplirvetengerekaqrrslaetlqqegsenghgvvf 1102
Cdd:COG3209 884 GNLTSRTDGGTTTYTYDAlGRLVSVTKpDGTTTTYTYDA----------------------------------------- 922
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1103 paelvrlldrleeeiradrvssesrawlaqcgltveqlarqvepeytparkahLYHCDHRGLPLALISEDGNTAWSAEYD 1182
Cdd:COG3209 923 -----------------------------------------------------LGHTDHLGSVRALTDASGQVVWRYDYD 949
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 1183 EWGNQLNEENPHhVYQPYCLPGQQHDEESGLYYNRHRYYDPLQGRYITQDPMGLKGGWNLYQYPL-NPLQQIDPMGLLQT 1261
Cdd:COG3209 950 PFGNLLAETSGA-AANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPDPIGLAGGLNLYAYVGnNPVNYVDPLGLAAL 1028
|
1130 1140 1150
....*....|....*....|....*....|....*.
gi 510927607 1262 WDDARSGACTGGVCGVLSRIIGPSKFDSTADAALDA 1297
Cdd:COG3209 1029 LGTTGLGGGAGVGAGAAGGGAAAAGGSAGAGAAGGG 1064
|
|
| Rhs_assc_core |
TIGR03696 |
RHS repeat-associated core domain; This model represents a conserved unique core sequence ... |
1181-1258 |
5.79e-28 |
|
RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.
Pssm-ID: 274730 [Multi-domain] Cd Length: 77 Bit Score: 107.97 E-value: 5.79e-28
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 510927607 1181 YDEWGNQLNEENphHVYQPYCLPGQQHDEESGLYYNRHRYYDPLQGRYITQDPMGLKGGWNLYQY-PLNPLQQIDPMGL 1258
Cdd:TIGR03696 1 YDPYGEVLSESG--AAPNPLRFTGQYYDAETGLYYNGARYYDPELGRFLSPDPIGLGGGLNLYAYvGNNPVNWVDPLGL 77
|
|
| DUF6531 |
pfam20148 |
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins. |
46-123 |
6.20e-19 |
|
Domain of unknown function (DUF6531); This putative domain is found in a range of RHS proteins.
Pssm-ID: 466309 [Multi-domain] Cd Length: 74 Bit Score: 82.19 E-value: 6.20e-19
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 510927607 46 GNPVNPLLGAKVLPgETDLALPGPLPFILSRTYSSYRTRTpapvGVFGPGWKAPSDIRLQLRDD-ALVLNDNGGRSIHF 123
Cdd:pfam20148 1 GDPVNVATGNKVLE-ETDFSLPGPLPLVWTRTYNSSSERD----GPLGPGWSHPYDQRLELEGDgGVVYIDADGREVTF 74
|
|
| RhsA |
COG3209 |
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ... |
59-758 |
6.17e-16 |
|
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];
Pssm-ID: 442442 [Multi-domain] Cd Length: 1103 Bit Score: 83.65 E-value: 6.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 59 PGETDLALPGPLPFILSRTYSSYRTRTPAPVGVFGPGWKAPSDIRLQLRDDALVLNDNGGRSIHFEPLLPGEAVYSRSES 138
Cdd:COG3209 180 PATGVGTGAVTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 139 MWLVRGGKAAQPDGHTLARLWGALPPDIRLSPHLYLATNSAQGPWWILGWSERVPGAEDVLPAPLPPYRVLTGMADRFGR 218
Cdd:COG3209 260 GGTTGAGTGASGAGLDASTGTGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTG 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 219 TLTYRREAAGDLAGEITGVTDGAGREFRLVLTTQAQRAEEARTSSLSSSDSSRPLSASAFPDTLPGTEYGPDRGIRLSAV 298
Cdd:COG3209 340 TGTGGTTTTVGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGP 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 299 WLMHDPAYPESLPAAPLVRYTYTEAGELLAVYDRSNTQVRAFTYDAQHPGRMVAHRYAGRPEMRYRYDDTGRVVEQLNPA 378
Cdd:COG3209 420 ATAAGALTAGGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTD 499
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 379 GLSYRYLYEQDRITVTDSLNRREVLHTEGGAGLKRVVKKELADGSVTRSGYDAAGRLTAQTDAAGRRTEYGLNVVSGDIT 458
Cdd:COG3209 500 TTLDDTLGGTTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGAS 579
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 459 DITTPDGRETKFYYNDGNQLTAVVSPDGLESRREYDEPGRLVSETSRSGETVRYRYDDAHSELPATTTDATGSTRQMTWS 538
Cdd:COG3209 580 TTTGTTGGTATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGTGVTTTGTTTTRA 659
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 539 RYGQLLAFTDCSGYQTRYEYDRFGQMTAVHREEGISLYRRYDNRGRLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSE 618
Cdd:COG3209 660 TGTTGTGTGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGG 739
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 510927607 619 TQYDAWGKAVSTTQGGLTRSMEYDAAGRVISLTNENGSHSV-----FSYDALDRLVQQGGFDGRTQRYHYDLTGKLTQ-- 691
Cdd:COG3209 740 TTGTLTTTSTTTTTTAGALTYTYDALGRLTSETTPGGVTQGtyttrYTYDALGRLTSVTYPDGETVTYTYDALGRLTSvi 819
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 510927607 692 -----SEDEGLVILWYYDESDRITHRT---VNGEPAEQWQYDGHGWLTDISHLSEGHRvavhYGYDDKGRLTGER 758
Cdd:COG3209 820 tvgsgGGTDLQDRTYTYDAAGNITSITdalRAGTLTQTYTYDALGRLTSATDPGTTES----YTYDANGNLTSRT 890
|
|
| RHS |
pfam03527 |
RHS protein; |
1155-1191 |
1.98e-12 |
|
RHS protein;
Pssm-ID: 427349 [Multi-domain] Cd Length: 38 Bit Score: 62.71 E-value: 1.98e-12
10 20 30
....*....|....*....|....*....|....*..
gi 510927607 1155 HLYHCDHRGLPLALISEDGNTAWSAEYDEWGNQLNEE 1191
Cdd:pfam03527 2 YYYHTDHLGTPEELTDEAGEIVWSAEYDAWGNVTEER 38
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
579-615 |
2.02e-08 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 51.45 E-value: 2.02e-08
10 20 30
....*....|....*....|....*....|....*..
gi 510927607 579 YDNRGRLTSVKDAQGRETRYEYNAAGDLTAVITPDGN 615
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| PAAR_2 |
cd14738 |
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR ... |
3-29 |
8.70e-08 |
|
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat family, where it forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). The T6SS is responsible for translocation of a wide variety of toxic effector molecules, allowing predatory cells to kill prokaryotic as well as eukaryotic prey cells. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes. It has been shown that PAAR proteins are essential for T6SS-mediated secretion and target cell killing by Vibrio cholerae (encodes two PAAR proteins) and Acinetobacter baylyi (encodes three PAAR proteins); inactivation of all these PAAR genes results in inactivation of Hcp secretion as well as T6SS-dependent killing of E. coli.
Pssm-ID: 269823 Cd Length: 94 Bit Score: 51.09 E-value: 8.70e-08
10 20
....*....|....*....|....*..
gi 510927607 3 GKPAARQGDMTQYGGPIVQGSAGVRIG 29
Cdd:cd14738 68 GKPAARMGDSTAHGGVIVSGVPTVLIG 94
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
579-620 |
1.96e-07 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 48.74 E-value: 1.96e-07
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 510927607 579 YDNRGRLTSVKDAQGRETRYEYNAAGDLTAVITPDGNRSETQ 620
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
|
|
| PAAR |
COG4104 |
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular ... |
3-48 |
1.53e-05 |
|
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 443280 Cd Length: 87 Bit Score: 44.81 E-value: 1.53e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 510927607 3 GKPAARQGDMTQYGGPIVQGSAGVRIG----APTG--VACSVC-PGGMTSGNP 48
Cdd:COG4104 2 PKPAARLGDKTSHGGPVISGSPTVLIGgrpaARVGdkVSCPKHgPDTIAEGSP 54
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
429-466 |
6.72e-05 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 41.43 E-value: 6.72e-05
10 20 30
....*....|....*....|....*....|....*...
gi 510927607 429 YDAAGRLTAQTDAAGRRTEYGLNvVSGDITDITTPDGR 466
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYD-AAGRLTAVTDPDGT 37
|
|
| PAAR |
COG4104 |
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular ... |
3-29 |
7.98e-05 |
|
Zn-binding Pro-Ala-Ala-Arg (PAAR) domain, involved in Type VI secretion [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 443280 Cd Length: 87 Bit Score: 42.49 E-value: 7.98e-05
10 20
....*....|....*....|....*..
gi 510927607 3 GKPAARQGDMTQYGGPIVQGSAGVRIG 29
Cdd:COG4104 60 GKPAARVGDKTACGGTIISGSPTVLIG 86
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
641-677 |
1.52e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 40.27 E-value: 1.52e-04
10 20 30
....*....|....*....|....*....|....*..
gi 510927607 641 YDAAGRVISLTNENGSHSVFSYDALDRLVQQGGFDGR 677
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
537-572 |
2.12e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.89 E-value: 2.12e-04
10 20 30
....*....|....*....|....*....|....*.
gi 510927607 537 WSRYGQLLAFTDCSGYQTRYEYDRFGQMTAVHREEG 572
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
413-444 |
3.54e-04 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 39.12 E-value: 3.54e-04
10 20 30
....*....|....*....|....*....|..
gi 510927607 413 RVVKKELADGSVTRSGYDAAGRLTAQTDAAGR 444
Cdd:pfam05593 6 RLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
413-448 |
9.85e-04 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 38.34 E-value: 9.85e-04
10 20 30
....*....|....*....|....*....|....*.
gi 510927607 413 RVVKKELADGSVTRSGYDAAGRLTAQTDAAGRRTEY 448
Cdd:TIGR01643 6 RLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
493-531 |
1.53e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 37.58 E-value: 1.53e-03
10 20 30
....*....|....*....|....*....|....*....
gi 510927607 493 YDEPGRLVSETSRSGETVRYRYDDAHseLPATTTDATGS 531
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAG--RLTAVTDPDGT 37
|
|
| PAAR_2 |
cd14738 |
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR ... |
3-29 |
1.86e-03 |
|
proline-alanine-alanine-arginine (PAAR) domain; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat family, where it forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). The T6SS is responsible for translocation of a wide variety of toxic effector molecules, allowing predatory cells to kill prokaryotic as well as eukaryotic prey cells. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes. It has been shown that PAAR proteins are essential for T6SS-mediated secretion and target cell killing by Vibrio cholerae (encodes two PAAR proteins) and Acinetobacter baylyi (encodes three PAAR proteins); inactivation of all these PAAR genes results in inactivation of Hcp secretion as well as T6SS-dependent killing of E. coli.
Pssm-ID: 269823 Cd Length: 94 Bit Score: 39.15 E-value: 1.86e-03
10 20 30
....*....|....*....|....*....|
gi 510927607 3 GKPAARQGDMTQYGGP---IVQGSAGVRIG 29
Cdd:cd14738 38 GLPAARVGDMCVCVGPpdtIVQGSSTVLIG 67
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
472-512 |
2.27e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 37.18 E-value: 2.27e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 510927607 472 YNDGNQLTAVVSPDGLESRREYDEPGRLVSETSRSGETVRY 512
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRY 41
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
558-594 |
3.14e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.42 E-value: 3.14e-03
10 20 30
....*....|....*....|....*....|....*..
gi 510927607 558 YDRFGQMTAVHREEGISLYRRYDNRGRLTSVKDAQGR 594
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| RHS_repeat |
pfam05593 |
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ... |
472-508 |
3.57e-03 |
|
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.
Pssm-ID: 461685 [Multi-domain] Cd Length: 37 Bit Score: 36.42 E-value: 3.57e-03
10 20 30
....*....|....*....|....*....|....*..
gi 510927607 472 YNDGNQLTAVVSPDGLESRREYDEPGRLVSETSRSGE 508
Cdd:pfam05593 1 YDAAGRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDGT 37
|
|
| PAAR_like |
cd14671 |
proline-alanine-alanine-arginine (PAAR) repeat superfamily; This domain is found in the PAAR ... |
5-48 |
4.07e-03 |
|
proline-alanine-alanine-arginine (PAAR) repeat superfamily; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat superfamily, where it forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). The T6SS is responsible for translocation of a wide variety of toxic effector molecules, allowing predatory cells to kill prokaryotic as well as eukaryotic prey cells. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. The PAAR-repeat proteins form a diverse superfamily with several subgroups extended both N- and C-terminally by domains with various predicted functions; the termini are exposed to solution, and do not distort the VgrG binding site. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes. It has been shown that PAAR proteins are essential for T6SS-mediated secretion and target cell killing by Vibrio cholerae (encodes two PAAR proteins) and Acinetobacter baylyi (encodes three PAAR proteins); inactivation of all these PAAR genes results in inactivation of Hcp secretion as well as T6SS-dependent killing of E. coli.
Pssm-ID: 269821 Cd Length: 77 Bit Score: 37.69 E-value: 4.07e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 510927607 5 PAARQGDMTQ--YGGPIVQGSAGVRIG---APTGVACSVCPGG---MTSGNP 48
Cdd:cd14671 1 PAARVGDPTAhtPGGPVISGSPNVFINgrpAARVGDVGDHPGGgnaIVSGSG 52
|
|
| YD_repeat_2x |
TIGR01643 |
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ... |
600-637 |
5.26e-03 |
|
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.
Pssm-ID: 273728 [Multi-domain] Cd Length: 42 Bit Score: 36.03 E-value: 5.26e-03
10 20 30 40
....*....|....*....|....*....|....*....|
gi 510927607 600 YNAAGDLTAVITPDGNRSETQYDAWGKAVSTT--QGGLTR 637
Cdd:TIGR01643 1 YDAAGRLTGSTDADGTTTRYTYDAAGRLVEITdaDGGSTR 40
|
|
| PAAR_CT_1 |
cd14743 |
proline-alanine-alanine-arginine (PAAR) domain with C-terminal extension; This domain is found ... |
3-39 |
5.91e-03 |
|
proline-alanine-alanine-arginine (PAAR) domain with C-terminal extension; This domain is found in the PAAR (proline-alanine-alanine-arginine) repeat family of mostly gamma-proteobacteria, and forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS). Some members contains C-terminal domain extensions corresponding to Rearrangement hotspot (Rhs) protein repeats and conserved Rhs repeat-associated unique core sequences as well as uncharacterized domains. However, these terminal domains are exposed to solution, and do not distort the binding site of VgrG. Rhs and related YD-peptide repeat proteins are widely distributed in bacteria. Rhs shares similar architecture with distantly related WapA proteins of Bacillus and Listeria species, suggesting intercellular growth inhibition as its primary function. Additionally, a plasmid-encoded Rhs protein has been implicated in bacteriocin production in Pseudomonas savastanoi. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes.
Pssm-ID: 269828 Cd Length: 78 Bit Score: 36.90 E-value: 5.91e-03
10 20 30
....*....|....*....|....*....|....*...
gi 510927607 3 GKPAARQGDMTQYGGPIVQGSAGVRI-GAPTGVACSVC 39
Cdd:cd14743 31 GLPAARVGDKTSCGATIVSGSINVLInGKPAAVLGSTT 68
|
|
| PAAR_RHS |
cd14742 |
proline-alanine-alanine-arginine (PAAR) domain, also containing C-terminal Rearrangement ... |
3-29 |
7.17e-03 |
|
proline-alanine-alanine-arginine (PAAR) domain, also containing C-terminal Rearrangement hotspot (Rhs) extensions; This PAAR (proline-alanine-alanine-arginine) repeat subfamily, which forms a sharp conical extension on the VgrG spike, a trimeric protein complex of the bacterial type VI secretion system (T6SS), contains C- and N-terminal domain extensions. These include Rearrangement hotspot (Rhs) protein repeats and conserved Rhs repeat-associated unique core sequences at the C-terminal, and various predicted functions at N- and C-terminal extensions. However, these terminal domains are exposed to solution, and do not distort the binding site of VgrG. Rhs and related YD-peptide repeat proteins are widely distributed in bacteria. Rhs shares similar architecture with distantly related WapA proteins of Bacillus and Listeria species, suggesting intercellular growth inhibition as its primary function. Additionally, a plasmid-encoded Rhs protein has been implicated in bacteriocin production in Pseudomonas savastanoi. The pointed tip of the PAAR domain is stabilized by a zinc atom positioned close to the cone's vertex and is likely to be important for its integrity during penetration of the target cell envelope. VgrG proteins are orthologous to the central baseplate spikes of bacteriophages with contractile tails, and genes encoding proteins with PAAR motifs have been frequently found immediately downstream from vgrG-like genes.
Pssm-ID: 269827 Cd Length: 86 Bit Score: 37.18 E-value: 7.17e-03
10 20
....*....|....*....|....*..
gi 510927607 3 GKPAARQGDMTQYGGPIVQGSAGVRIG 29
Cdd:cd14742 60 GQPAARKGDKTTCSAVISEGSPNVFIG 86
|
|
| |
