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Conserved domains on  [gi|511756146|ref|WP_016389466|]
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MULTISPECIES: FeoA family protein [Cycloclasticus]

Protein Classification

FeoA family protein( domain architecture ID 10004922)

FeoA family protein similar to ferrous iron transport protein A (FeoA), which is part of the Feo (ferrous iron-transport) system that functions in the uptake of ferrous iron

CATH:  2.30.30.90
Gene Ontology:  GO:0046914|GO:0006826
PubMed:  26684538|8407793|35012344
TCDB:  9.A.8.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
12-80 3.65e-10

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


:

Pssm-ID: 441522  Cd Length: 73  Bit Score: 50.52  E-value: 3.65e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 511756146 12 TLADIEIGQEVMLCKNQMAHSLEKKLLTLGFSKLIPLQVTQRS--KGGIIVSIGNTRIALNETLAKQVVIE 80
Cdd:COG1918   2 TLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAplGGPLVVRVGGTRIALRREEAAKILVE 72
 
Name Accession Description Interval E-value
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
12-80 3.65e-10

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 50.52  E-value: 3.65e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 511756146 12 TLADIEIGQEVMLCKNQMAHSLEKKLLTLGFSKLIPLQVTQRS--KGGIIVSIGNTRIALNETLAKQVVIE 80
Cdd:COG1918   2 TLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAplGGPLVVRVGGTRIALRREEAAKILVE 72
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 12-80 1.24e-06

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 41.81  E-value: 1.24e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 511756146  12 TLADIEIGQE---VMLCKNQmaHSLEKKLLTLGFSKLIPLQVTQRS--KGGIIVSIGNTRIALNETLAKQVVIE 80
Cdd:pfam04023  2 PLSELKEGETariVRIRDGD--PELLRRLLELGLVPGAEVTVVRKApfGGPIIVRVGGTRIALRREEASKIFVE 73
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 12-80 6.67e-04

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 34.47  E-value: 6.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 511756146   12 TLADIEIGQEVMLCK-NQMAHSLEKKLLTLGFSKLIPLQVTQRSKGG-IIVSIGNtRIALNETLAKQVVIE 80
Cdd:smart00899  2 PLSELKPGEKARIVRiRDEDPELLRRLLELGLVPGTEVTVLRKAPFGpLVVRVGG-ELALRREEAEKIFVE 71
 
Name Accession Description Interval E-value
FeoA COG1918
Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];
12-80 3.65e-10

Fe2+ transport protein FeoA [Inorganic ion transport and metabolism];


Pssm-ID: 441522  Cd Length: 73  Bit Score: 50.52  E-value: 3.65e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 511756146 12 TLADIEIGQEVMLCKNQMAHSLEKKLLTLGFSKLIPLQVTQRS--KGGIIVSIGNTRIALNETLAKQVVIE 80
Cdd:COG1918   2 TLSELKPGEKARIVRISGDGELRRRLLELGLVPGTEVEVVRKAplGGPLVVRVGGTRIALRREEAAKILVE 72
FeoA pfam04023
FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. ...
 12-80 1.24e-06

FeoA domain; This family includes FeoA a small protein, probably involved in Fe2+ transport. This presumed short domain is also found at the C-terminus of a variety of metal dependent transcriptional regulators. This suggests that this domain may be metal-binding. In most cases this is likely to be either iron or manganese.


Pssm-ID: 461133  Cd Length: 74  Bit Score: 41.81  E-value: 1.24e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 511756146  12 TLADIEIGQE---VMLCKNQmaHSLEKKLLTLGFSKLIPLQVTQRS--KGGIIVSIGNTRIALNETLAKQVVIE 80
Cdd:pfam04023  2 PLSELKEGETariVRIRDGD--PELLRRLLELGLVPGAEVTVVRKApfGGPIIVRVGGTRIALRREEASKIFVE 73
FeoA smart00899
This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found ...
 12-80 6.67e-04

This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; This domain also occurs at the C-terminus in related proteins. The transporter Feo is composed of three proteins: FeoA a small, soluble SH3-domain protein probably located in the cytosol; FeoB, a large protein with a cytosolic N-terminal G-protein domain and a C-terminal integral inner-membrane domain containing two 'Gate' motifs which likely functions as the Fe2+ permease; and FeoC, a small protein apparently functioning as an [Fe-S]-dependent transcriptional repressor. Feo allows the bacterial cell to acquire iron from its environment.


Pssm-ID: 214896  Cd Length: 72  Bit Score: 34.47  E-value: 6.67e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 511756146   12 TLADIEIGQEVMLCK-NQMAHSLEKKLLTLGFSKLIPLQVTQRSKGG-IIVSIGNtRIALNETLAKQVVIE 80
Cdd:smart00899  2 PLSELKPGEKARIVRiRDEDPELLRRLLELGLVPGTEVTVLRKAPFGpLVVRVGG-ELALRREEAEKIFVE 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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