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Conserved domains on  [gi|512464543|ref|WP_016422636|]
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MULTISPECIES: carboxymuconolactone decarboxylase family protein [Corynebacterium]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ahpD super family cl39101
alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which ...
 2-172 8.16e-69

alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon. [Cellular processes, Detoxification]


The actual alignment was detected with superfamily member TIGR00777:

Pssm-ID: 129859 [Multi-domain]  Cd Length: 177  Bit Score: 206.74  E-value: 8.16e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464543    2 SIDNLRSGLPEYAKDMKLNLGTLTRSTELSEQQLWGTLLASAAATRNETVFSEIAEEAKEHLSDEAFESALGAATVMGMN 81
Cdd:TIGR00777   1 SIEKLKAALPDYAKDLKLNLSSITRSSVLDQEQLWGTLLASAAATRNPQVLRDIGAEATAHLSAEARHAALGAAAIMAMN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464543   82 NVAYRTRHML-GDDYAQVKFGLRMNIISNPGVEKEDFELWSLAVSAINGCEACVTSHAKVVRDAGLTKEQVWEAVKIAGT 160
Cdd:TIGR00777  81 NVFYRGRHLLeGARYDDLRPGLRMNIIANPGIPKVNFELWSFAVSAINGCGHCLDSHEHTLRTVGVDREAIQEALKIAAV 160

                         170
                  ....*....|..
gi 512464543  161 VSGVAQAVFAEA 172
Cdd:TIGR00777 161 VSAVAQTLAAEA 172
 
Name Accession Description Interval E-value
ahpD TIGR00777
alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which ...
 2-172 8.16e-69

alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon. [Cellular processes, Detoxification]


Pssm-ID: 129859 [Multi-domain]  Cd Length: 177  Bit Score: 206.74  E-value: 8.16e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464543    2 SIDNLRSGLPEYAKDMKLNLGTLTRSTELSEQQLWGTLLASAAATRNETVFSEIAEEAKEHLSDEAFESALGAATVMGMN 81
Cdd:TIGR00777   1 SIEKLKAALPDYAKDLKLNLSSITRSSVLDQEQLWGTLLASAAATRNPQVLRDIGAEATAHLSAEARHAALGAAAIMAMN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464543   82 NVAYRTRHML-GDDYAQVKFGLRMNIISNPGVEKEDFELWSLAVSAINGCEACVTSHAKVVRDAGLTKEQVWEAVKIAGT 160
Cdd:TIGR00777  81 NVFYRGRHLLeGARYDDLRPGLRMNIIANPGIPKVNFELWSFAVSAINGCGHCLDSHEHTLRTVGVDREAIQEALKIAAV 160

                         170
                  ....*....|..
gi 512464543  161 VSGVAQAVFAEA 172
Cdd:TIGR00777 161 VSAVAQTLAAEA 172
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 101-170 2.28e-11

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 56.94  E-value: 2.28e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464543  101 GLRMNIISNPGVEKEDFELWSLAVSAINGCEACVTSHAKVVRDAGLTKEQVWEAVKIAGTVSGVAQAVFA 170
Cdd:pfam02627   9 ALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAA 78
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 94-170 3.65e-07

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 46.48  E-value: 3.65e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512464543  94 DYAQVKFGLRMNIISNPGVEKEDFELWSLAVSAINGCEACVTSHAKVVRDAGLTKEQVWEAVKIAGTVSGVAQAVFA 170
Cdd:COG0599   24 EFAEAFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGFPAALNA 100
 
Name Accession Description Interval E-value
ahpD TIGR00777
alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which ...
 2-172 8.16e-69

alkylhydroperoxidase, AhpD family; Members of this family are alkylhydroperoxidases, which catalyze the reduction of peroxides to their corresponding alcohols via oxidation of cysteine residues. In these alkylhydroperoxidases, the cysteines are located in a conserved -CXXC- motif located towards the COOH terminus. In Mycobacterium tuberculosis, two non-homologous alkylhydroperoxidases, AhpD and AhpC, are found in the same operon. [Cellular processes, Detoxification]


Pssm-ID: 129859 [Multi-domain]  Cd Length: 177  Bit Score: 206.74  E-value: 8.16e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464543    2 SIDNLRSGLPEYAKDMKLNLGTLTRSTELSEQQLWGTLLASAAATRNETVFSEIAEEAKEHLSDEAFESALGAATVMGMN 81
Cdd:TIGR00777   1 SIEKLKAALPDYAKDLKLNLSSITRSSVLDQEQLWGTLLASAAATRNPQVLRDIGAEATAHLSAEARHAALGAAAIMAMN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464543   82 NVAYRTRHML-GDDYAQVKFGLRMNIISNPGVEKEDFELWSLAVSAINGCEACVTSHAKVVRDAGLTKEQVWEAVKIAGT 160
Cdd:TIGR00777  81 NVFYRGRHLLeGARYDDLRPGLRMNIIANPGIPKVNFELWSFAVSAINGCGHCLDSHEHTLRTVGVDREAIQEALKIAAV 160

                         170
                  ....*....|..
gi 512464543  161 VSGVAQAVFAEA 172
Cdd:TIGR00777 161 VSAVAQTLAAEA 172
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 101-170 2.28e-11

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 56.94  E-value: 2.28e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464543  101 GLRMNIISNPGVEKEDFELWSLAVSAINGCEACVTSHAKVVRDAGLTKEQVWEAVKIAGTVSGVAQAVFA 170
Cdd:pfam02627   9 ALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAA 78
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 110-158 5.18e-10

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 52.37  E-value: 5.18e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 512464543  110 PGVEKEDFELWSLAVSAINGCEACVTSHAKVVRDAGLTKEQVWEAVKIA 158
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEALAWA 49
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 94-170 3.65e-07

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 46.48  E-value: 3.65e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512464543  94 DYAQVKFGLRMNIISNPGVEKEDFELWSLAVSAINGCEACVTSHAKVVRDAGLTKEQVWEAVKIAGTVSGVAQAVFA 170
Cdd:COG0599   24 EFAEAFEALFGDVWARGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREEIAEALLVAAVYAGFPAALNA 100
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 106-151 1.60e-05

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 42.56  E-value: 1.60e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 512464543 106 IISNPGVEKEDFELWSLAVSAINGCEACVTSHAKVVRDAGLTKEQV 151
Cdd:COG2128   16 LMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERI 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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