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Conserved domains on  [gi|512464744|ref|WP_016422780|]
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MULTISPECIES: metalloregulator ArsR/SmtB family transcription factor [Corynebacterium]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 16677510)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-89 3.51e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


:

Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 89.83  E-value: 3.51e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512464744  14 ATSVLKLMADKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSSFYSQPDEHLTNLV 89
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-89 3.51e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 89.83  E-value: 3.51e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512464744  14 ATSVLKLMADKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSSFYSQPDEHLTNLV 89
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-96 7.67e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 86.87  E-value: 7.67e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464744   6 PTSTELDVATSVLKLMADKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSSFYSQPDEHL 85
Cdd:COG0640    2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81

                         90
                 ....*....|.
gi 512464744  86 TNLVVNALHFA 96
Cdd:COG0640   82 AELLEWLLELL 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-94 5.76e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 71.56  E-value: 5.76e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 512464744  18 LKLMADKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSSFYS-QPDEHLTNLVVNALH 94
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSlTDAERLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-93 1.22e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 65.31  E-value: 1.22e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512464744    28 SILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSSFYSQPDEHLTNLVVNAL 93
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-67 2.54e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.99  E-value: 2.54e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 512464744   23 DKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMV 67
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 19-73 4.09e-11

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 55.21  E-value: 4.09e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 512464744  19 KLMADKTRLSILSLLRD-GEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEG 73
Cdd:PRK10141  11 KILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQG 66
 
Name Accession Description Interval E-value
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 14-89 3.51e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 89.83  E-value: 3.51e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512464744  14 ATSVLKLMADKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSSFYSQPDEHLTNLV 89
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-96 7.67e-24

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 86.87  E-value: 7.67e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464744   6 PTSTELDVATSVLKLMADKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSSFYSQPDEHL 85
Cdd:COG0640    2 SETKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEAL 81

                         90
                 ....*....|.
gi 512464744  86 TNLVVNALHFA 96
Cdd:COG0640   82 AELLEWLLELL 92
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-94 5.76e-18

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 71.56  E-value: 5.76e-18
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 512464744  18 LKLMADKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSSFYS-QPDEHLTNLVVNALH 94
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSlTDAERLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
28-93 1.22e-15

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 65.31  E-value: 1.22e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 512464744    28 SILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSSFYSQPDEHLTNLVVNAL 93
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEELL 66
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
14-72 5.23e-13

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 59.59  E-value: 5.23e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 512464744  14 ATSVLKLMADKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKE 72
Cdd:COG4189    9 SLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYK 67
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 23-67 2.54e-11

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 53.99  E-value: 2.54e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 512464744   23 DKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMV 67
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 19-73 4.09e-11

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 55.21  E-value: 4.09e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 512464744  19 KLMADKTRLSILSLLRD-GEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEG 73
Cdd:PRK10141  11 KILSDETRLGIVLLLREsGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQG 66
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 17-73 1.30e-10

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 52.54  E-value: 1.30e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 512464744   17 VLKLMADKTRLSILS-LLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEG 73
Cdd:pfam12840   3 VAEALADPTRLRILRaLVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREG 60
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
17-76 6.99e-10

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 51.96  E-value: 6.99e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 512464744  17 VLKLMADKTRLSILSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKEGTSS 76
Cdd:COG1777   10 LLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYREGRED 69
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
21-72 1.18e-04

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 39.14  E-value: 1.18e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 512464744  21 MADKTRLSILSLLR-DGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKE 72
Cdd:COG2345   10 LADPTRRRILELLKrAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVERETE 62
TrmB pfam01978
Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown ...
 30-72 7.35e-03

Sugar-specific transcriptional regulator TrmB; One member of this family, TrmB, has been shown to be a sugar-specific transcriptional regulator of the trehalose/maltose ABC transporter in Thermococcus litoralis.


Pssm-ID: 396525 [Multi-domain]  Cd Length: 67  Bit Score: 32.49  E-value: 7.35e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 512464744   30 LSLLRDGEMTVTAIASTLDRPVPAISQHLAKLRMANMVQTRKE 72
Cdd:pfam01978  15 LALLKLGPATADEIAEESGVPRSKVYEVLRSLEDKGLVEREKG 57
PRK05638 PRK05638
threonine synthase; Validated
 25-78 7.63e-03

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 34.40  E-value: 7.63e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 512464744  25 TRLSILSLLRDGEMTVTAIASTLDRP--VPAISQHLAKL-RMANMVQTRKEGTSSFY 78
Cdd:PRK05638 372 TKLEILKILSEREMYGYEIWKALGKPlkYQAVYQHIKELeELGLIEEAYRKGRRVYY 428
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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