|
Name |
Accession |
Description |
Interval |
E-value |
| QcrB/PetB |
COG1290 |
Cytochrome b subunit of the bc complex [Energy production and conversion]; |
1-425 |
2.57e-133 |
|
Cytochrome b subunit of the bc complex [Energy production and conversion];
Pssm-ID: 440901 [Multi-domain] Cd Length: 393 Bit Score: 393.00 E-value: 2.57e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 1 MSNPTKLATAAKNMDDRYTLSGGMRKQLNKVFPTHW--SFLLGEIALYSFVVLLFSGVYLTLFFDPSMSkviydgayapl 78
Cdd:COG1290 1 MSTTKKASGLADWLDERLPLASLVREHLEYPFPKNWnfSYWFGELALYSFVIQILTGIFLTMYYKPSAS----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 79 ngvemsRAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYS 158
Cdd:COG1290 70 ------EAFASVEYIMRDVPGGWLIRYMHHWGASLFFAAVYLHMFRGFFYGAYKKPRELNWIIGVLLLLLTMAEAFTGYS 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 159 LPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDFPGDMIIPRLYIAHVLILPALLLGLIAAHLALVWYQKHTQFPGA 238
Cdd:COG1290 144 LPWDQLSYWGARVITGLFGAIPVIGTWLVTWLFGGEFPGDATLNRFFALHVLLLPALLLALVVLHLWLLHRHGHNNPPGP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 239 GRTE-NNVVGVRILPIFAVKSVSFGLITFGFLALFAGIFQINAIWNLGPYNPAQVSAGSQPDIYMLWTDGAARVMPPWEL 317
Cdd:COG1290 224 ERKKtEKVDGVPFHPYYTVKDGFGFFVFLGVFALLAFFFPINPPPNYGPANPLATPAHIQPDWYFLPFYGILRAIPGSAK 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 318 YLGSYTIPAVFwvallcgvlvVLLFAYPFIEAKITgdnahhnllQRPRDVPVRSGLGAMALVFYTLLTLSGGNDLIAYHF 397
Cdd:COG1290 304 LGGVIAMGLAI----------LVLFLLPFLDRSPV---------RSPRYRPVRTALGVAFIVFFIVLTILGANPPIATLL 364
|
410 420
....*....|....*....|....*...
gi 512465226 398 QiSLNVMTWVgRIGLIILPPIAYFVTYR 425
Cdd:COG1290 365 G-SINTVTYF-AFFLIVLPILAFIEKTK 390
|
|
| Cytochrom_B_N_2 |
pfam13631 |
Cytochrome b(N-terminal)/b6/petB; |
112-286 |
1.93e-57 |
|
Cytochrome b(N-terminal)/b6/petB;
Pssm-ID: 433364 Cd Length: 169 Bit Score: 188.99 E-value: 1.93e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 112 LLFAVSIMAHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMF 191
Cdd:pfam13631 1 YIFIAAIYVHMLRIFFTGAYRKPRELNWIIGVLLLLLTLGEGFTGYSLPDDLLSGTGLRIGLGILSSIPVVGTWLVWLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 192 NGDFPGDMIIPRLYIAHVLILPALLLGLIAAHLALVwyQKHTQFPGAGrTENNVVGVRILPIFAVKSVSFGLItfgFLAL 271
Cdd:pfam13631 81 GGPFPGTATIPRFYALHILLLPGLILALIVAHLLLV--EKHGQFPPPG-TEKNVVGVPFWPVFAVKMLLFFLI---TVAL 154
|
170
....*....|....*
gi 512465226 272 FAGIFQINAIWNLGP 286
Cdd:pfam13631 155 LIGLAQINPIWLGGP 169
|
|
| cytb_ExtP |
NF040969 |
selenite/tellurite reduction operon b-type cytochrome ExtP; |
38-209 |
2.26e-30 |
|
selenite/tellurite reduction operon b-type cytochrome ExtP;
Pssm-ID: 468899 Cd Length: 205 Bit Score: 117.78 E-value: 2.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 38 FLLGEIALYSFVVLLFSGVYLTLFFDPSMSkviydgayaplngvemsRAYETALQISFEVRGGLFIRQIHHWGALLFAVS 117
Cdd:NF040969 25 WCLGGLTFLLFVILTVTGIFLMFYYVPTPE-----------------AAYESVQYLQNEVAFGQLVRNMHHWAANLMVVM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 118 IMAHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDFPG 197
Cdd:NF040969 88 VFLHMLRVFYTGSYKPPREFNWVVGVGLLVLTLGLSFTGYLLPWDQLAYWAVTVGTNIAGSIPVVGTLLQLLQLGGSEVG 167
|
170
....*....|..
gi 512465226 198 DMIIPRLYIAHV 209
Cdd:NF040969 168 AATLTRFYALHV 179
|
|
| PRK03735 |
PRK03735 |
cytochrome b6; Provisional |
40-209 |
3.52e-26 |
|
cytochrome b6; Provisional
Pssm-ID: 179639 Cd Length: 223 Bit Score: 106.33 E-value: 3.52e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 40 LGEIALYSFVVLLFSGVYLTLFFDPSMSKviydgayaplngvemsrAYETALQISFEVRGGLFIRQIHHWGALLFAVSIM 119
Cdd:PRK03735 44 FGGLTFFCFVIQILSGMFLTMYYVPDIKN-----------------AYESVYYLQNEVAFGWIVRGMHHWGASLVIVMMF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 120 AHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDFPGDM 199
Cdd:PRK03735 107 LHTLRVFFTGGYKKPRELNWVVGVLIFFVTVGLGFTGYLLPWDQKAYFATKVGSQIAEAIPVIGDFIKTLLRGGEIVGAQ 186
|
170
....*....|
gi 512465226 200 IIPRLYIAHV 209
Cdd:PRK03735 187 TLTRFFAIHV 196
|
|
| Cytochrome_b_N |
cd00284 |
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ... |
40-209 |
3.04e-22 |
|
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.
Pssm-ID: 238176 Cd Length: 200 Bit Score: 94.74 E-value: 3.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 40 LGEIALYSFVVLLFSGVYLTLFFDPSMSKviydgayaplngvemsrAYETALQISFEVRGGLFIRQIHHWGALLFAVSIM 119
Cdd:cd00284 25 FGSLLGTCLVIQILTGVFLAMHYTPDVTL-----------------AFSSVQYIMRDVNFGWLIRSLHANGASMFFLMLY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 120 AHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDFPGDM 199
Cdd:cd00284 88 LHIFRGLYYGSYKKPRELTWVIGVILLLLTMATAFMGYVLPWGQMSYWGATVITNLFSAIPVIGITLVEWLWGGFSVDNA 167
|
170
....*....|
gi 512465226 200 IIPRLYIAHV 209
Cdd:cd00284 168 TLTRFFALHF 177
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| QcrB/PetB |
COG1290 |
Cytochrome b subunit of the bc complex [Energy production and conversion]; |
1-425 |
2.57e-133 |
|
Cytochrome b subunit of the bc complex [Energy production and conversion];
Pssm-ID: 440901 [Multi-domain] Cd Length: 393 Bit Score: 393.00 E-value: 2.57e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 1 MSNPTKLATAAKNMDDRYTLSGGMRKQLNKVFPTHW--SFLLGEIALYSFVVLLFSGVYLTLFFDPSMSkviydgayapl 78
Cdd:COG1290 1 MSTTKKASGLADWLDERLPLASLVREHLEYPFPKNWnfSYWFGELALYSFVIQILTGIFLTMYYKPSAS----------- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 79 ngvemsRAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYS 158
Cdd:COG1290 70 ------EAFASVEYIMRDVPGGWLIRYMHHWGASLFFAAVYLHMFRGFFYGAYKKPRELNWIIGVLLLLLTMAEAFTGYS 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 159 LPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDFPGDMIIPRLYIAHVLILPALLLGLIAAHLALVWYQKHTQFPGA 238
Cdd:COG1290 144 LPWDQLSYWGARVITGLFGAIPVIGTWLVTWLFGGEFPGDATLNRFFALHVLLLPALLLALVVLHLWLLHRHGHNNPPGP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 239 GRTE-NNVVGVRILPIFAVKSVSFGLITFGFLALFAGIFQINAIWNLGPYNPAQVSAGSQPDIYMLWTDGAARVMPPWEL 317
Cdd:COG1290 224 ERKKtEKVDGVPFHPYYTVKDGFGFFVFLGVFALLAFFFPINPPPNYGPANPLATPAHIQPDWYFLPFYGILRAIPGSAK 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 318 YLGSYTIPAVFwvallcgvlvVLLFAYPFIEAKITgdnahhnllQRPRDVPVRSGLGAMALVFYTLLTLSGGNDLIAYHF 397
Cdd:COG1290 304 LGGVIAMGLAI----------LVLFLLPFLDRSPV---------RSPRYRPVRTALGVAFIVFFIVLTILGANPPIATLL 364
|
410 420
....*....|....*....|....*...
gi 512465226 398 QiSLNVMTWVgRIGLIILPPIAYFVTYR 425
Cdd:COG1290 365 G-SINTVTYF-AFFLIVLPILAFIEKTK 390
|
|
| Cytochrom_B_N_2 |
pfam13631 |
Cytochrome b(N-terminal)/b6/petB; |
112-286 |
1.93e-57 |
|
Cytochrome b(N-terminal)/b6/petB;
Pssm-ID: 433364 Cd Length: 169 Bit Score: 188.99 E-value: 1.93e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 112 LLFAVSIMAHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMF 191
Cdd:pfam13631 1 YIFIAAIYVHMLRIFFTGAYRKPRELNWIIGVLLLLLTLGEGFTGYSLPDDLLSGTGLRIGLGILSSIPVVGTWLVWLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 192 NGDFPGDMIIPRLYIAHVLILPALLLGLIAAHLALVwyQKHTQFPGAGrTENNVVGVRILPIFAVKSVSFGLItfgFLAL 271
Cdd:pfam13631 81 GGPFPGTATIPRFYALHILLLPGLILALIVAHLLLV--EKHGQFPPPG-TEKNVVGVPFWPVFAVKMLLFFLI---TVAL 154
|
170
....*....|....*
gi 512465226 272 FAGIFQINAIWNLGP 286
Cdd:pfam13631 155 LIGLAQINPIWLGGP 169
|
|
| cytb_ExtP |
NF040969 |
selenite/tellurite reduction operon b-type cytochrome ExtP; |
38-209 |
2.26e-30 |
|
selenite/tellurite reduction operon b-type cytochrome ExtP;
Pssm-ID: 468899 Cd Length: 205 Bit Score: 117.78 E-value: 2.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 38 FLLGEIALYSFVVLLFSGVYLTLFFDPSMSkviydgayaplngvemsRAYETALQISFEVRGGLFIRQIHHWGALLFAVS 117
Cdd:NF040969 25 WCLGGLTFLLFVILTVTGIFLMFYYVPTPE-----------------AAYESVQYLQNEVAFGQLVRNMHHWAANLMVVM 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 118 IMAHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDFPG 197
Cdd:NF040969 88 VFLHMLRVFYTGSYKPPREFNWVVGVGLLVLTLGLSFTGYLLPWDQLAYWAVTVGTNIAGSIPVVGTLLQLLQLGGSEVG 167
|
170
....*....|..
gi 512465226 198 DMIIPRLYIAHV 209
Cdd:NF040969 168 AATLTRFYALHV 179
|
|
| PRK03735 |
PRK03735 |
cytochrome b6; Provisional |
40-209 |
3.52e-26 |
|
cytochrome b6; Provisional
Pssm-ID: 179639 Cd Length: 223 Bit Score: 106.33 E-value: 3.52e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 40 LGEIALYSFVVLLFSGVYLTLFFDPSMSKviydgayaplngvemsrAYETALQISFEVRGGLFIRQIHHWGALLFAVSIM 119
Cdd:PRK03735 44 FGGLTFFCFVIQILSGMFLTMYYVPDIKN-----------------AYESVYYLQNEVAFGWIVRGMHHWGASLVIVMMF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 120 AHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDFPGDM 199
Cdd:PRK03735 107 LHTLRVFFTGGYKKPRELNWVVGVLIFFVTVGLGFTGYLLPWDQKAYFATKVGSQIAEAIPVIGDFIKTLLRGGEIVGAQ 186
|
170
....*....|
gi 512465226 200 IIPRLYIAHV 209
Cdd:PRK03735 187 TLTRFFAIHV 196
|
|
| Cytochrome_B |
pfam00033 |
Cytochrome b/b6/petB; |
40-209 |
2.52e-22 |
|
Cytochrome b/b6/petB;
Pssm-ID: 306530 Cd Length: 189 Bit Score: 94.37 E-value: 2.52e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 40 LGEIALYSFVVLLFSGVYLTLFFDPSMSKviydgayaplngvemsrAYETALQISFEVRGGLFIRQIHHWGALLFAVSIM 119
Cdd:pfam00033 16 FGSLLGLCLAVQILTGVFLAFYYTPDVTL-----------------AFLSVQYIMRDVNFGWLIRSVHANGASMFFLMLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 120 AHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDFPGDM 199
Cdd:pfam00033 79 LHIFRGLYYGGFSYPRELTWVIGVILLVLTMSTAFIGYVLPWGQMSYWGATVITNLLSAIPVIGDTLVEWIWGSFSVDQA 158
|
170
....*....|
gi 512465226 200 IIPRLYIAHV 209
Cdd:pfam00033 159 TLTRFFSLHF 168
|
|
| Cytochrome_b_N |
cd00284 |
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ... |
40-209 |
3.04e-22 |
|
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.
Pssm-ID: 238176 Cd Length: 200 Bit Score: 94.74 E-value: 3.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 40 LGEIALYSFVVLLFSGVYLTLFFDPSMSKviydgayaplngvemsrAYETALQISFEVRGGLFIRQIHHWGALLFAVSIM 119
Cdd:cd00284 25 FGSLLGTCLVIQILTGVFLAMHYTPDVTL-----------------AFSSVQYIMRDVNFGWLIRSLHANGASMFFLMLY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 120 AHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDFPGDM 199
Cdd:cd00284 88 LHIFRGLYYGSYKKPRELTWVIGVILLLLTMATAFMGYVLPWGQMSYWGATVITNLFSAIPVIGITLVEWLWGGFSVDNA 167
|
170
....*....|
gi 512465226 200 IIPRLYIAHV 209
Cdd:cd00284 168 TLTRFFALHF 177
|
|
| petB |
CHL00070 |
cytochrome b6 |
29-208 |
6.58e-19 |
|
cytochrome b6
Pssm-ID: 177009 Cd Length: 215 Bit Score: 85.54 E-value: 6.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 29 NKVFPTHWS--FLLGEIALYSFVVLLFSGVYLTLFFDPSMSKviydgayaplngvemsrAYETALQISFEVRGGLFIRQI 106
Cdd:CHL00070 23 SKYVPPHVNifYCLGGITLTCFLVQVATGFAMTFYYRPTVTE-----------------AFASVQYIMTEVNFGWLIRSV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 107 HHWGALLFAVSIMAHMFRIFFTGAFRKPREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWL 186
Cdd:CHL00070 86 HRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVVLAVLTVSFGVTGYSLPWDQIGYWAVKIVTGVPEAIPVIGSPL 165
|
170 180
....*....|....*....|..
gi 512465226 187 HWMMFNGDFPGDMIIPRLYIAH 208
Cdd:CHL00070 166 VELLRGSVSVGQSTLTRFYSLH 187
|
|
| CYTB |
MTH00016 |
cytochrome b; Validated |
36-186 |
6.46e-09 |
|
cytochrome b; Validated
Pssm-ID: 177102 [Multi-domain] Cd Length: 378 Bit Score: 57.76 E-value: 6.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 36 WSF--LLGeialYSFVVLLFSGVYLTLFFDPSMSKviydgayaplngvemsrAYETALQISFEVRGGLFIRQIHHWGALL 113
Cdd:MTH00016 32 WNFgsLLG----LCLVIQILTGLFLSMHYTPHIDL-----------------AFSSVAHISRDVNYGWLLRNLHANGASF 90
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512465226 114 FAVSIMAHMFRIFFTGAFRkpREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWL 186
Cdd:MTH00016 91 FFICLYLHIGRGIYYGSYF--LMETWNIGVILLLLTMATAFLGYVLPWGQMSFWGATVITNLLSAIPYIGKML 161
|
|
| CYTB |
MTH00224 |
cytochrome b; Provisional |
75-189 |
2.63e-08 |
|
cytochrome b; Provisional
Pssm-ID: 164767 [Multi-domain] Cd Length: 379 Bit Score: 56.08 E-value: 2.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 75 YAPlnGVEMsrAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRkpREANWVIGSILLLLSVAEGF 154
Cdd:MTH00224 56 YAP--NIEM--AFSSVAHISRDVNYGWLLRSIHANGASMFFLFIYLHVGRGLYYGSFN--LSETWNIGVILFILTMATAF 129
|
90 100 110
....*....|....*....|....*....|....*.
gi 512465226 155 MGYSLPDDLLSGVGLRIMSAIIIGLPIIG-TWLHWM 189
Cdd:MTH00224 130 LGYVLPWGQMSFWGATVITNLFSAIPYIGkDLVEWI 165
|
|
| CYTB |
MTH00145 |
cytochrome b; Provisional |
86-189 |
8.47e-08 |
|
cytochrome b; Provisional
Pssm-ID: 177203 [Multi-domain] Cd Length: 379 Bit Score: 54.53 E-value: 8.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 86 AYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRKPReaNWVIGSILLLLSVAEGFMGYSLPDDLLS 165
Cdd:MTH00145 63 AFSSVIHIMRDVNYGWLLRSLHANGASFFFICIYLHIGRGLYYGSYLMQH--TWNIGVTLLLLSMGTAFLGYVLPWGQMS 140
|
90 100
....*....|....*....|....*
gi 512465226 166 GVGLRIMSAIIIGLPIIGTWL-HWM 189
Cdd:MTH00145 141 FWGATVITNLLSAIPYVGKMLvEWV 165
|
|
| CYTB |
MTH00074 |
cytochrome b; Provisional |
84-186 |
6.60e-07 |
|
cytochrome b; Provisional
Pssm-ID: 177145 [Multi-domain] Cd Length: 380 Bit Score: 51.61 E-value: 6.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 84 SRAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRkpREANWVIGSILLLLSVAEGFMGYSLPDDL 163
Cdd:MTH00074 61 SSAFSSVAHICRDVNYGWLMRNIHANGASFFFICIYLHIGRGLYYGSYM--YKETWNIGVILLFLVMATAFVGYVLPWGQ 138
|
90 100
....*....|....*....|...
gi 512465226 164 LSGVGLRIMSAIIIGLPIIGTWL 186
Cdd:MTH00074 139 MSFWGATVITNLLSAIPYMGDTL 161
|
|
| CYTB |
MTH00034 |
cytochrome b; Validated |
82-186 |
2.44e-06 |
|
cytochrome b; Validated
Pssm-ID: 177109 [Multi-domain] Cd Length: 379 Bit Score: 49.70 E-value: 2.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 82 EMSRAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRKprEANWVIGSILLLLSVAEGFMGYSLPD 161
Cdd:MTH00034 58 DISLAFSSVSHICRDVNYGWLLRNIHANGASLFFICLYFHIGRGLYYGSYVN--IETWNIGVILFLLTMLTAFVGYVLPW 135
|
90 100
....*....|....*....|....*
gi 512465226 162 DLLSGVGLRIMSAIIIGLPIIGTWL 186
Cdd:MTH00034 136 GQMSFWAATVITNLVSAVPYIGTDI 160
|
|
| CYTB |
MTH00100 |
cytochrome b; Provisional |
84-186 |
3.54e-06 |
|
cytochrome b; Provisional
Pssm-ID: 177162 [Multi-domain] Cd Length: 379 Bit Score: 49.25 E-value: 3.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 84 SRAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRKPReaNWVIGSILLLLSVAEGFMGYSLPDDL 163
Cdd:MTH00100 60 TTAFSSVAHICRDVNYGWIIRYLHANGASMFFICLFLHVGRGLYYGSYLFLE--TWNIGIILLFTVMATAFMGYVLPWGQ 137
|
90 100
....*....|....*....|...
gi 512465226 164 LSGVGLRIMSAIIIGLPIIGTWL 186
Cdd:MTH00100 138 MSFWGATVITNLLSAIPYIGTTL 160
|
|
| CYTB |
MTH00119 |
cytochrome b; Provisional |
84-160 |
8.23e-06 |
|
cytochrome b; Provisional
Pssm-ID: 214425 [Multi-domain] Cd Length: 380 Bit Score: 47.97 E-value: 8.23e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512465226 84 SRAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRKprEANWVIGSILLLLSVAEGFMGYSLP 160
Cdd:MTH00119 61 SLAFSSVAHICRDVQYGWLIRNLHANGASMFFICIYLHIGRGLYYGSYLY--KETWNTGVILLLLLMATAFVGYVLP 135
|
|
| CYTB |
MTH00191 |
cytochrome b; Provisional |
83-160 |
8.80e-06 |
|
cytochrome b; Provisional
Pssm-ID: 177239 [Multi-domain] Cd Length: 365 Bit Score: 47.99 E-value: 8.80e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 512465226 83 MSRAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRkpREANWVIGSILLLLSVAEGFMGYSLP 160
Cdd:MTH00191 56 ISLAFSSVVHICRDVNYGWLLRNIHANGASFFFICIYLHIGRGLYYGSYL--NKETWNVGVILLILSMATAFLGYVLP 131
|
|
| CYTB |
MTH00022 |
cytochrome b; Validated |
82-184 |
1.58e-05 |
|
cytochrome b; Validated
Pssm-ID: 164595 [Multi-domain] Cd Length: 379 Bit Score: 47.39 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 82 EMSRAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRKprEANWVIGSILLLLSVAEGFMGYSLPD 161
Cdd:MTH00022 57 DVSLAFASVGHIMRDVNYGFLLRYLHANGASLFFLCLYIHIGRGLYYGGYLK--FHVWNVGVVIFLLTMATAFMGYVLPW 134
|
90 100
....*....|....*....|...
gi 512465226 162 DLLSGVGLRIMSAIIIGLPIIGT 184
Cdd:MTH00022 135 GQMSFWGATVITNLLSAIPYVGT 157
|
|
| CYTB |
MTH00131 |
cytochrome b; Provisional |
82-186 |
2.20e-05 |
|
cytochrome b; Provisional
Pssm-ID: 177189 [Multi-domain] Cd Length: 380 Bit Score: 46.95 E-value: 2.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 82 EMSRAYETALQISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFTGAFRkpREANWVIGSILLLLSVAEGFMGYSLPD 161
Cdd:MTH00131 58 DISTAFSSVAHICRDVNYGWLIRNLHANGASFFFICIYLHIGRGLYYGSYL--YKETWNIGVVLLLLVMMTAFVGYVLPW 135
|
90 100
....*....|....*....|....*
gi 512465226 162 DLLSGVGLRIMSAIIIGLPIIGTWL 186
Cdd:MTH00131 136 GQMSFWGATVITNLLSAVPYVGNTL 160
|
|
| CYTB |
MTH00046 |
cytochrome b; Validated |
102-187 |
2.83e-05 |
|
cytochrome b; Validated
Pssm-ID: 177121 [Multi-domain] Cd Length: 355 Bit Score: 46.51 E-value: 2.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 102 FIRQIHHWGALLFAVSIMAHMFRIFFTGAFRKprEANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPI 181
Cdd:MTH00046 69 CVRYWHIWGVNVLFILLFIHMGRALYYSSYSK--KGVWNVGFILYLLVMVEAFLGYILPWHQMSYWAATVLTSIVDSVPI 146
|
....*.
gi 512465226 182 IGTWLH 187
Cdd:MTH00046 147 VGSLVY 152
|
|
| CYTB |
MTH00086 |
cytochrome b; Provisional |
49-195 |
6.67e-05 |
|
cytochrome b; Provisional
Pssm-ID: 177151 [Multi-domain] Cd Length: 355 Bit Score: 45.32 E-value: 6.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512465226 49 VVLLFSGVYLTLFFDPsmskviyDGAYApLNGVEMsrayetalqISFEVRGGLFIRQIHHWGALLFAVSIMAHMFRIFFT 128
Cdd:MTH00086 31 VFQILTGTFLAFYYTA-------DSSMA-FSSVQY---------IMYEVNFGWLFRIFHFNGASLFFIFLYLHIFKGLFM 93
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512465226 129 GAFRkpREANWVIGSILLLLSVAEGFMGYSLPDDLLSGVGLRIMSAIIIGLPIIGTWLHWMMFNGDF 195
Cdd:MTH00086 94 MSYR--LKKVWISGLTIYLLVMMEAFMGYVLVWAQMSFWAAVVITSLLSVIPIWGPSIVMWIWGGFG 158
|
|
| PH_Cool_Pix |
cd01225 |
Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain; There ... |
51-101 |
7.17e-03 |
|
Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain; There are two forms of Pix proteins: alpha Pix (also called Rho guanine nucleotide exchange factor (GEF) 6/90Cool-2) and beta Pix (GEF7/p85Cool-1). betaPix contains an N-terminal SH3 domain, a RhoGEF/DH domain, a PH domain, a GIT1 binding domain (GBD), and a C-terminal coiled-coil (CC) domain. alphaPix differs in that it contains a calponin homology (CH) domain, which interacts with beta-parvin, N-terminal to the SH3 domain. alphaPix is an exchange factor for Rac1 and Cdc42 and mediates Pak activation on cell adhesion to fibronectin. Mutations in alphaPix can cause X-linked mental retardation. alphaPix also interacts with Huntington's disease protein (htt), and enhances the aggregation of mutant htt (muthtt) by facilitating SDS-soluble muthtt-muthtt interactions. The DH-PH domain of a Pix was required for its binding to htt. In the majority of Rho GEF proteins, the DH-PH domain is responsible for the exchange activity. PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.
Pssm-ID: 269932 Cd Length: 100 Bit Score: 36.14 E-value: 7.17e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 512465226 51 LLFSGVYLTLFFDPSMSKVIYDGAYaPLNGVEMSRAYET-ALQISFEVRGGL 101
Cdd:cd01225 23 LLFPHVLLMLSASPRMSGFIYEGKL-PLTGISVNRLEDTeGIKNAFEISGPL 73
|
|
| |
