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Conserved domains on  [gi|512627998|ref|WP_016459928|]
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anaerobic ribonucleoside-triphosphate reductase [Acidaminococcus intestini]

Protein Classification

anaerobic ribonucleoside-triphosphate reductase( domain architecture ID 11483698)

anaerobic ribonucleoside-triphosphate reductase, a class III ribonucleotide reductase, uses an oxygen-sensitive glycyl radical and an iron-sulfur cluster to catalyze the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides during anaerobic conditions

EC:  1.17.4.2
Gene Ontology:  GO:0008998|GO:0005524

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09263 PRK09263
anaerobic ribonucleoside triphosphate reductase; Provisional
 1-710 0e+00

anaerobic ribonucleoside triphosphate reductase; Provisional


:

Pssm-ID: 236436 [Multi-domain]  Cd Length: 711  Bit Score: 1134.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   1 MGMQVIKRDGSTVSFDRHKIVVAIQKANKAVE-EGERLPESDIDTIASFVEGKKRkrFLVEDIQDMVEKQIMNRGRYELA 79
Cdd:PRK09263   1 MMPKVIKRDGRKVPFDSEKIKNAIEKAAKAVEvDDEDYCATVAAEIASRVEGRDE--VDIEEIQDAVENQLMAGPYKALA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  80 KAYIIYRYNRALVRKANTT-DESILSLISNKNKDVMEENSNKNAVMVSTQRDLIAGEVSRDLTRRIVLPEKISRAHDEGI 158
Cdd:PRK09263  79 RAYIEYRHDRDIAREKATDlNEEIRGLIEQSNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRHLLPRDVVNAHEKGD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 159 LHFHDSDYF-IQPMFNCCLINIGDMLDNGTVMHGKLIESPKSFQVACTVMTQIIASVASAQYGGQSVDI--SHLGKYLRR 235
Cdd:PRK09263 159 IHYHDLDYSpFFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRidEVLAPYAEK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 236 SRDKFRKRlVESTQGslsEKELNEILDARMKEELASGVQTIQYQINTLMTTNGQSPFVTLFLHLDPKDEYIEenaqIIEE 315
Cdd:PRK09263 239 SYEKHLKD-AEEWVI---EEKAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRL----IQKA 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 316 ILKQRLEGIKNEAGvyvTPAFPKLVYVLDENNCLKGGKYDY-LTELAVRCSIKRMYPDYISAKKMREnYEGNVFSPMGCR 394
Cdd:PRK09263 311 ILRNRIAGLGKERK---TAIFPKLVFAIKDGLNLKPGDPNYdIKQLALECATKRMYPDILNYDKIVE-LTGSFKTPMGCR 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 395 SFLVPWKDKDGHYKFEGRFNQGVVSINLPQIGIIAKGDEDKFWKLLDERLELCREALMVRHNALKGIRSDVSPIHWQNGA 474
Cdd:PRK09263 387 SFLQGWKDENGEEVHDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGA 466

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 475 IA-RLKKGETIDKLLENGYSTLSLGYIGLYECTVAMKGCSHTT-PEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPA 552
Cdd:PRK09263 467 FGvRLKADDDVDELFKNGRATISLGYIGLYETINALYGGSWEVnPEAKAFALAIVKRMKDACDQWKKETGYGFSLYSTPS 546

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 553 ESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDVREHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVR 632
Cdd:PRK09263 547 ESLTDRFCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKALEAVWD 626

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 633 FIYDNIQYAEFNTKSDYCQVCGFDGEIKVNDNlEWECPQCHNKDQSKMNVVRRTCGYLGEN---FWNVGKTKEIKSRVLH 709
Cdd:PRK09263 627 YSYDRVGYLGTNTPIDECYECGFTGEFECTEK-GFTCPKCGNHDPKTVSVTRRTCGYLGNPdarPFNHGRQEEIKRRVKH 705


                 .
gi 512627998 710 L 710
Cdd:PRK09263 706 M 706
 
Name Accession Description Interval E-value
PRK09263 PRK09263
anaerobic ribonucleoside triphosphate reductase; Provisional
 1-710 0e+00

anaerobic ribonucleoside triphosphate reductase; Provisional


Pssm-ID: 236436 [Multi-domain]  Cd Length: 711  Bit Score: 1134.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   1 MGMQVIKRDGSTVSFDRHKIVVAIQKANKAVE-EGERLPESDIDTIASFVEGKKRkrFLVEDIQDMVEKQIMNRGRYELA 79
Cdd:PRK09263   1 MMPKVIKRDGRKVPFDSEKIKNAIEKAAKAVEvDDEDYCATVAAEIASRVEGRDE--VDIEEIQDAVENQLMAGPYKALA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  80 KAYIIYRYNRALVRKANTT-DESILSLISNKNKDVMEENSNKNAVMVSTQRDLIAGEVSRDLTRRIVLPEKISRAHDEGI 158
Cdd:PRK09263  79 RAYIEYRHDRDIAREKATDlNEEIRGLIEQSNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRHLLPRDVVNAHEKGD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 159 LHFHDSDYF-IQPMFNCCLINIGDMLDNGTVMHGKLIESPKSFQVACTVMTQIIASVASAQYGGQSVDI--SHLGKYLRR 235
Cdd:PRK09263 159 IHYHDLDYSpFFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRidEVLAPYAEK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 236 SRDKFRKRlVESTQGslsEKELNEILDARMKEELASGVQTIQYQINTLMTTNGQSPFVTLFLHLDPKDEYIEenaqIIEE 315
Cdd:PRK09263 239 SYEKHLKD-AEEWVI---EEKAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRL----IQKA 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 316 ILKQRLEGIKNEAGvyvTPAFPKLVYVLDENNCLKGGKYDY-LTELAVRCSIKRMYPDYISAKKMREnYEGNVFSPMGCR 394
Cdd:PRK09263 311 ILRNRIAGLGKERK---TAIFPKLVFAIKDGLNLKPGDPNYdIKQLALECATKRMYPDILNYDKIVE-LTGSFKTPMGCR 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 395 SFLVPWKDKDGHYKFEGRFNQGVVSINLPQIGIIAKGDEDKFWKLLDERLELCREALMVRHNALKGIRSDVSPIHWQNGA 474
Cdd:PRK09263 387 SFLQGWKDENGEEVHDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGA 466

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 475 IA-RLKKGETIDKLLENGYSTLSLGYIGLYECTVAMKGCSHTT-PEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPA 552
Cdd:PRK09263 467 FGvRLKADDDVDELFKNGRATISLGYIGLYETINALYGGSWEVnPEAKAFALAIVKRMKDACDQWKKETGYGFSLYSTPS 546

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 553 ESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDVREHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVR 632
Cdd:PRK09263 547 ESLTDRFCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKALEAVWD 626

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 633 FIYDNIQYAEFNTKSDYCQVCGFDGEIKVNDNlEWECPQCHNKDQSKMNVVRRTCGYLGEN---FWNVGKTKEIKSRVLH 709
Cdd:PRK09263 627 YSYDRVGYLGTNTPIDECYECGFTGEFECTEK-GFTCPKCGNHDPKTVSVTRRTCGYLGNPdarPFNHGRQEEIKRRVKH 705


                 .
gi 512627998 710 L 710
Cdd:PRK09263 706 M 706
NrdD COG1328
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ...
 1-699 0e+00

Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis


Pssm-ID: 440939 [Multi-domain]  Cd Length: 671  Bit Score: 864.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   1 MGMQVIKRDGSTVSFDRHKIVVAIQKANKAVEEGERLPEsDIDTIASFVEGK-----KRKRFLVEDIQDMVEKQIMNRGR 75
Cdd:COG1328    1 MMLKVIKRDGRVVPFDPEKIANAIKKAAKAVGGEDRDEE-LAEEIADEVEKElerlgGGGTITVEEIQDIVEKVLMESGH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  76 YELAKAYIIYRYNRALVRKANTTDESILSLISNKNKDVMEENSNKNAVmVSTQRDLIAGEVSRDLTRRIVLPEKISRAHD 155
Cdd:COG1328   80 PEVAKAYILYREQRTRLREARTTLVDDIELLDEYDDWRVNENANKSYS-FSTQRDLIAGEVSKEYALNKILPPEVADAHR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 156 EGILHFHDSDYFIQpMFNCCLINIGDMLDNGTVMHGKLIESPKSFQVACTVMTQIIASVASAQYGGQSVD--ISHLGKYL 233
Cdd:COG1328  159 NGDIHIHDLDYLPR-MTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSrfDTYLAPYV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 234 RRsrdkfrkrlvestqgslsekelnEILDARMKEELASGVQTIQYQINTLMTTNGQSPFVTLFLHLDPKDEYIEENAQII 313
Cdd:COG1328  238 RK-----------------------DKLEGKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGTPEDFSWEMRMIN 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 314 EEILKQRLEGIKNEAgvyvTPAFPKLVYVLDEN-NCLKGGKYDYLTELAVRCSIKRMYPDYISAKKMRENYEGNVFSPMG 392
Cdd:COG1328  295 KAILEVRIEGDGEGR----TFIFPKLIFNITEGfNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELYKGSFKRSMG 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 393 CRSFLVPWKDkdGHYKFEGRFNQGVVSINLPQIGIIAKGDEDKFWKLLDERLELCREALMVRHNALKGI-RSDVSPIHWQ 471
Cdd:COG1328  371 CRLFLDGWEN--GEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKLaKAGLAPILYQ 448

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 472 NGAIA-RLKKGETIDKLLENGYSTLslGYIGLYECTVAMKGCSH-TTPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYG 549
Cdd:COG1328  449 TGAYLgRLKPDDSIDELFKNGFSTI--GYIGLNEMLLNFTGKHHiESEEAKAFALEILKHMRERADEWQEETGYLYSLYA 526

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 550 TPAESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDVREHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVED 629
Cdd:COG1328  527 TPAESLTYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEALEA 606

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512627998 630 LVRFIYDN--IQYAEFNTKSDYCQVCGFDGEIKVndnlewECPQCHNKDqsKMNVVRRTCGYLGEN-FWNVGK 699
Cdd:COG1328  607 VVRYAYDNyrIGYLGINPPFDICPKCGYLGGEHD------ECPKCGNED--TVEVIRRTCGYLGNVqPWNDGK 671
NRDD pfam13597
Anaerobic ribonucleoside-triphosphate reductase;
117-709 0e+00

Anaerobic ribonucleoside-triphosphate reductase;


Pssm-ID: 463930 [Multi-domain]  Cd Length: 554  Bit Score: 731.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  117 NSNKNAVMVSTQRDLIAGEVSRDLTRRIVLPEKISRAHDEGILHFHDSDYFIQPMFNCCLINIGDMLDNGTVMHGKLIES 196
Cdd:pfam13597   1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYALRTPYCCGIDLRDLLENGFVTGNGVSRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  197 PKSFQVACTVMTQIIASVASAQYGGQSVD--ISHLGKYLRRSRDKFRKRLVestqgslsekelneildarmKEELASGVQ 274
Cdd:pfam13597  81 PKHIETACAQAVNILATVQNEQAGGQAFSsfDTYLAPFVRKDYEKHLKGLT--------------------YKEVKQAMQ 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  275 TIQYQINTLMTTNG-QSPFVTLFLHLDPKDEYIEENAQIIEEILKQRLEGIKNEagvyVTPA-FPKLVYVLDEN-NCLKG 351
Cdd:pfam13597 141 AFVYNLNTMPSRRGgQTPFTNINLGLDTPKEGRDEMDMIIKALLEVMLEGDGNG----GTPFtFPIPIYKLKEGfNWDEG 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  352 GKYDYLTELAVRCSIKRMYPDYISAKkmRENYEGNVFS-PMGCRSFLVPWKDKdghYKFEG-RFNQGVVSINLPQIGIIA 429
Cdd:pfam13597 217 DPNYDLFELAFECTAKRGYPYFSNFD--SDLLPGDGYVaSMGCRLRLDLRPNR---KRFGGlRGNIGVVTINLPRIAYEA 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  430 KGDEDKFWKLLDERLELCREALMVRHNALKGIRSDV-SPIHWQNGAiarlkkgetidklLENGYSTLSLGYIGLYECTVA 508
Cdd:pfam13597 292 AGDEDKFFELLDERLELAKEALLIRREVLKKLLAKGlLPFLMGEGY-------------LRGGNHTLTIGFIGLNEALKA 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  509 MKGCSHT-TPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDV 587
Cdd:pfam13597 359 LTGKHHGeSEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPV 438

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  588 REHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVRFIYD-NIQYAEFNTKSDYCQVCGFDGEIKvndnle 666
Cdd:pfam13597 439 DYTIDAFEKLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEIE------ 512

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 512627998  667 wECPQCHNKDQsKMNVVRRTCGYLGEN-FWNVGKTKEIKSRVLH 709
Cdd:pfam13597 513 -ECPNCGNHDE-KVEVIRRITGYLRPVsDWNKGKQAELKDRVKH 554
NrdD TIGR02487
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ...
 116-709 2.28e-171

anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]


Pssm-ID: 274159 [Multi-domain]  Cd Length: 579  Bit Score: 503.40  E-value: 2.28e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  116 ENSNKNAVMVSTQRDLIAGEVSRDLTRRIVLPEKISRAHDEGILHFHDSDYFIQPMFNCCLINIGDMLDNGTVMHGKLIE 195
Cdd:TIGR02487   2 ENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDYALTLTTNCCLHDLRNLLKYGFRTGNIVSK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  196 SPKSFQVACTVMTQIIASVASAQYGGQS---VDIsHLGKYLRRSRDKFRKRLvesTQGSLSEKELNEILDARMKEELASG 272
Cdd:TIGR02487  82 PPKHIDVALNHIVNILQSLQNEQYGGQSfpeFDT-LLAPYIEKTNLKHRKVL---QQLQLLLFEATEYAARRTFTDVTQA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  273 VQTIQYQINTLMTTNGQSPFVTLFLhldpKDEYIEENAQIIEEILKQRLEGIKNEAgvyvTPAFPKLVYVLDENNCLKGG 352
Cdd:TIGR02487 158 MQGPEYNPNTLHSAGGQTPFESIGY----GTETSKEGRMIAKALLDVRMEGDGKGE----PFIFPKIIFKVREGFNWDEP 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  353 KYDYLTELAVRCSIKRMYPDYISAKKMRENYEGNVfSPMGCRSFLVPWKDKDGHYKFEGRFNQGVVSINLPQIGIIAKGD 432
Cdd:TIGR02487 230 DPYDLFELAFECAAKRGYPYFLNLDPEDNVKEDVR-YPMGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRIAYKSRGD 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  433 EDKFWKLLDERLELCREALMVRHNALKGIRSDVSPIHWQNGAIAR-LKKGETIDKLLENGysTLSLGYIGLYECTVAMKG 511
Cdd:TIGR02487 309 EEEFFEELDEYLEIAKEALEIRREYLKKMLAKDLPPMYSQGGWDGgNLLDESVEEILKSG--TNSIGFIGLNEALVALTG 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  512 CS-HTTPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDVREH 590
Cdd:TIGR02487 387 KHlHEEEEARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYED 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  591 IDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVRFIYDN-IQYAEFNTKSDYCQVCGFDGEIkVNDnlewEC 669
Cdd:TIGR02487 467 VNLGEKIDIEAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKNgIGYFGINPPVDVCEDCGYTGEG-LND----KC 541

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|.
gi 512627998  670 PQCHNKDqskMNVVRRTCGYLGE-NFWNVGKTKEIKSRVLH 709
Cdd:TIGR02487 542 PKCGSHD---IEVISRITGYLGPvENWNDGKQAEFKDRKKH 579
RNR_III cd01675
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...
 116-691 1.40e-157

Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.


Pssm-ID: 153084 [Multi-domain]  Cd Length: 555  Bit Score: 467.16  E-value: 1.40e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 116 ENSNKNAVMVSTQRDLIAGEVSRDLTRRIvLPEKISRAHDEGILHFHDSDYFiQPMFNCCLINIGDMLDNGTVMHGKLIE 195
Cdd:cd01675    1 ENANVDSSPGSTMKDLAAGIVKKYYLLKI-LPKEIARAHLNGDIHIHDLDYL-PLTPYCCGWDLRPLLEKGFTTGNGIIE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 196 SPKSFQVACTVMTQIIASVASAQYGGQS---VDIsHLGKYLRRSRDKFRKRLVEstqgslsekelNEILDArmkeelasg 272
Cdd:cd01675   79 PPKHLSSALGHIVNFLGTVQNEQAGGQAfpeFDT-YLAPFVRKDYLKYRLTATR-----------KEIKQA--------- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 273 VQTIQYQINTLMTTNGQSPFVTLFLHLDPKD---------------EYIEENAQIIEEILKQRLEGIKNEAgvyvTPAFP 337
Cdd:cd01675  138 MQGFIYNLNTLSRRGGQTPFTNITLGLVCPKdlefegggepvftygDTDKEARMIQKAFLEVRLEGDAKGR----PFTFP 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 338 KLVYVLDENNcLKGGKYDyLTELAVRCSIKRMYPDYISAKkmRENYEGNVFSPMGCRSFLVPWKDKDGHYKFE---GRFN 414
Cdd:cd01675  214 IPTFNVTEGF-NLDPNYD-LKELAFECAAKRGYPYFLNFD--NSDNVPGDVRAMGCRLFLDKNELKRGGGLEGsgdGTGN 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 415 QGVVSINLPQIGIIAKGDEDKFWKLLDERLELCREALMVRHNALKGIRSDVSPIHWQNGAIARLKkgetidkLLENGYST 494
Cdd:cd01675  290 IGVVTINLPRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEGLGGGKL-------LFILKRHT 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 495 LSLGYIGLYECTVAMKGCSH-TTPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRFARIDKERFGT-IKD 572
Cdd:cd01675  363 LTIGFIGLNEAAEALTGKGIgESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGDiIPG 442

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 573 ITDKGYYTNSYHVDVREHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVRFIYDN-IQYAEFNTKSDYCQ 651
Cdd:cd01675  443 VTDKPYYTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDICN 522

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|
gi 512627998 652 VCGFDGEIKVNdnlewECPQCHNKDqskMNVVRRTCGYLG 691
Cdd:cd01675  523 DCGYIGEGEGF-----KCPKCGSED---VEVISRITGYLG 554
 
Name Accession Description Interval E-value
PRK09263 PRK09263
anaerobic ribonucleoside triphosphate reductase; Provisional
 1-710 0e+00

anaerobic ribonucleoside triphosphate reductase; Provisional


Pssm-ID: 236436 [Multi-domain]  Cd Length: 711  Bit Score: 1134.60  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   1 MGMQVIKRDGSTVSFDRHKIVVAIQKANKAVE-EGERLPESDIDTIASFVEGKKRkrFLVEDIQDMVEKQIMNRGRYELA 79
Cdd:PRK09263   1 MMPKVIKRDGRKVPFDSEKIKNAIEKAAKAVEvDDEDYCATVAAEIASRVEGRDE--VDIEEIQDAVENQLMAGPYKALA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  80 KAYIIYRYNRALVRKANTT-DESILSLISNKNKDVMEENSNKNAVMVSTQRDLIAGEVSRDLTRRIVLPEKISRAHDEGI 158
Cdd:PRK09263  79 RAYIEYRHDRDIAREKATDlNEEIRGLIEQSNEAVLNENANKDSKVFSTQRDLLAGIVSKHYALRHLLPRDVVNAHEKGD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 159 LHFHDSDYF-IQPMFNCCLINIGDMLDNGTVMHGKLIESPKSFQVACTVMTQIIASVASAQYGGQSVDI--SHLGKYLRR 235
Cdd:PRK09263 159 IHYHDLDYSpFFPMFNCCLIDLKGMLTNGFKIGNAEIESPKSIQTATAVTAQIIAQVASSQYGGCTINRidEVLAPYAEK 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 236 SRDKFRKRlVESTQGslsEKELNEILDARMKEELASGVQTIQYQINTLMTTNGQSPFVTLFLHLDPKDEYIEenaqIIEE 315
Cdd:PRK09263 239 SYEKHLKD-AEEWVI---EEKAEAYARARTEKEIYDAMQSLEYEINTLHTSNGQTPFVTLGFGLGTSWESRL----IQKA 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 316 ILKQRLEGIKNEAGvyvTPAFPKLVYVLDENNCLKGGKYDY-LTELAVRCSIKRMYPDYISAKKMREnYEGNVFSPMGCR 394
Cdd:PRK09263 311 ILRNRIAGLGKERK---TAIFPKLVFAIKDGLNLKPGDPNYdIKQLALECATKRMYPDILNYDKIVE-LTGSFKTPMGCR 386

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 395 SFLVPWKDKDGHYKFEGRFNQGVVSINLPQIGIIAKGDEDKFWKLLDERLELCREALMVRHNALKGIRSDVSPIHWQNGA 474
Cdd:PRK09263 387 SFLQGWKDENGEEVHDGRNNLGVVTLNLPRIALEAKGDEDKFWEILDERLELAKKALMTRIERLKGAKPRVAPILYMYGA 466

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 475 IA-RLKKGETIDKLLENGYSTLSLGYIGLYECTVAMKGCSHTT-PEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPA 552
Cdd:PRK09263 467 FGvRLKADDDVDELFKNGRATISLGYIGLYETINALYGGSWEVnPEAKAFALAIVKRMKDACDQWKKETGYGFSLYSTPS 546

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 553 ESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDVREHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVR 632
Cdd:PRK09263 547 ESLTDRFCRLDTEKFGVIPGITDKGYYTNSFHYDVRKKVNPFEKLDFEKPYPPLASGGFIHYCEYPNLQHNLKALEAVWD 626

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 633 FIYDNIQYAEFNTKSDYCQVCGFDGEIKVNDNlEWECPQCHNKDQSKMNVVRRTCGYLGEN---FWNVGKTKEIKSRVLH 709
Cdd:PRK09263 627 YSYDRVGYLGTNTPIDECYECGFTGEFECTEK-GFTCPKCGNHDPKTVSVTRRTCGYLGNPdarPFNHGRQEEIKRRVKH 705


                 .
gi 512627998 710 L 710
Cdd:PRK09263 706 M 706
NrdD COG1328
Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; ...
 1-699 0e+00

Anaerobic ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Anaerobic ribonucleoside-triphosphate reductase is part of the Pathway/BioSystem: Thymidylate biosynthesis


Pssm-ID: 440939 [Multi-domain]  Cd Length: 671  Bit Score: 864.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   1 MGMQVIKRDGSTVSFDRHKIVVAIQKANKAVEEGERLPEsDIDTIASFVEGK-----KRKRFLVEDIQDMVEKQIMNRGR 75
Cdd:COG1328    1 MMLKVIKRDGRVVPFDPEKIANAIKKAAKAVGGEDRDEE-LAEEIADEVEKElerlgGGGTITVEEIQDIVEKVLMESGH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  76 YELAKAYIIYRYNRALVRKANTTDESILSLISNKNKDVMEENSNKNAVmVSTQRDLIAGEVSRDLTRRIVLPEKISRAHD 155
Cdd:COG1328   80 PEVAKAYILYREQRTRLREARTTLVDDIELLDEYDDWRVNENANKSYS-FSTQRDLIAGEVSKEYALNKILPPEVADAHR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 156 EGILHFHDSDYFIQpMFNCCLINIGDMLDNGTVMHGKLIESPKSFQVACTVMTQIIASVASAQYGGQSVD--ISHLGKYL 233
Cdd:COG1328  159 NGDIHIHDLDYLPR-MTNCCLWDLRDLLKNGFNGGNGKVEPPKHIQTALAQMAQIIATVQSEQAGGQAFSrfDTYLAPYV 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 234 RRsrdkfrkrlvestqgslsekelnEILDARMKEELASGVQTIQYQINTLMTTNGQSPFVTLFLHLDPKDEYIEENAQII 313
Cdd:COG1328  238 RK-----------------------DKLEGKTYKEIKQAMQSLEYNLNTLPSRRGQTPFTSITFGLGTPEDFSWEMRMIN 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 314 EEILKQRLEGIKNEAgvyvTPAFPKLVYVLDEN-NCLKGGKYDYLTELAVRCSIKRMYPDYISAKKMRENYEGNVFSPMG 392
Cdd:COG1328  295 KAILEVRIEGDGEGR----TFIFPKLIFNITEGfNWEPEDPNYDLLQLAFECTAKRGYPYFLNYDNSDELYKGSFKRSMG 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 393 CRSFLVPWKDkdGHYKFEGRFNQGVVSINLPQIGIIAKGDEDKFWKLLDERLELCREALMVRHNALKGI-RSDVSPIHWQ 471
Cdd:COG1328  371 CRLFLDGWEN--GEELNRGRGNLGVVTLNLPRIAYEAKGDEEKFFEILDERLDLAKEALEIKRKRLQKLaKAGLAPILYQ 448

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 472 NGAIA-RLKKGETIDKLLENGYSTLslGYIGLYECTVAMKGCSH-TTPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYG 549
Cdd:COG1328  449 TGAYLgRLKPDDSIDELFKNGFSTI--GYIGLNEMLLNFTGKHHiESEEAKAFALEILKHMRERADEWQEETGYLYSLYA 526

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 550 TPAESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDVREHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVED 629
Cdd:COG1328  527 TPAESLTYRFAKLDKKRFGDIIGVTDKPYYTNSFHLPVRKTIDPFEKLDFEDEYQPLYTGGTISYVELGELQPNPEALEA 606

                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512627998 630 LVRFIYDN--IQYAEFNTKSDYCQVCGFDGEIKVndnlewECPQCHNKDqsKMNVVRRTCGYLGEN-FWNVGK 699
Cdd:COG1328  607 VVRYAYDNyrIGYLGINPPFDICPKCGYLGGEHD------ECPKCGNED--TVEVIRRTCGYLGNVqPWNDGK 671
NRDD pfam13597
Anaerobic ribonucleoside-triphosphate reductase;
117-709 0e+00

Anaerobic ribonucleoside-triphosphate reductase;


Pssm-ID: 463930 [Multi-domain]  Cd Length: 554  Bit Score: 731.22  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  117 NSNKNAVMVSTQRDLIAGEVSRDLTRRIVLPEKISRAHDEGILHFHDSDYFIQPMFNCCLINIGDMLDNGTVMHGKLIES 196
Cdd:pfam13597   1 NANKDSYSPSGQRLYIAGEVSKDYALRKLLPPEIADAHEEGDIHIHDLDYYALRTPYCCGIDLRDLLENGFVTGNGVSRP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  197 PKSFQVACTVMTQIIASVASAQYGGQSVD--ISHLGKYLRRSRDKFRKRLVestqgslsekelneildarmKEELASGVQ 274
Cdd:pfam13597  81 PKHIETACAQAVNILATVQNEQAGGQAFSsfDTYLAPFVRKDYEKHLKGLT--------------------YKEVKQAMQ 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  275 TIQYQINTLMTTNG-QSPFVTLFLHLDPKDEYIEENAQIIEEILKQRLEGIKNEagvyVTPA-FPKLVYVLDEN-NCLKG 351
Cdd:pfam13597 141 AFVYNLNTMPSRRGgQTPFTNINLGLDTPKEGRDEMDMIIKALLEVMLEGDGNG----GTPFtFPIPIYKLKEGfNWDEG 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  352 GKYDYLTELAVRCSIKRMYPDYISAKkmRENYEGNVFS-PMGCRSFLVPWKDKdghYKFEG-RFNQGVVSINLPQIGIIA 429
Cdd:pfam13597 217 DPNYDLFELAFECTAKRGYPYFSNFD--SDLLPGDGYVaSMGCRLRLDLRPNR---KRFGGlRGNIGVVTINLPRIAYEA 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  430 KGDEDKFWKLLDERLELCREALMVRHNALKGIRSDV-SPIHWQNGAiarlkkgetidklLENGYSTLSLGYIGLYECTVA 508
Cdd:pfam13597 292 AGDEDKFFELLDERLELAKEALLIRREVLKKLLAKGlLPFLMGEGY-------------LRGGNHTLTIGFIGLNEALKA 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  509 MKGCSHT-TPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDV 587
Cdd:pfam13597 359 LTGKHHGeSEEAKEFALKILKHMREKADEWKEETGLNFSLEATPAESLSYRFAKLDKKRFGEIKGVTDKPYYTNSFHVPV 438

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  588 REHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVRFIYD-NIQYAEFNTKSDYCQVCGFDGEIKvndnle 666
Cdd:pfam13597 439 DYTIDAFEKLKLEAPFQPLTTGGHISHVELGEAQPNPEALEKLVRIAYDtGIGYFSINPPIDVCPDCGYTGEIE------ 512

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....
gi 512627998  667 wECPQCHNKDQsKMNVVRRTCGYLGEN-FWNVGKTKEIKSRVLH 709
Cdd:pfam13597 513 -ECPNCGNHDE-KVEVIRRITGYLRPVsDWNKGKQAELKDRVKH 554
NrdD TIGR02487
anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive ...
 116-709 2.28e-171

anaerobic ribonucleoside-triphosphate reductase; This model represents the oxygen-sensitive (anaerobic, class III) ribonucleotide reductase. The mechanism of the enzyme involves a glycine-centered radical, a C-terminal zinc binding site, and a set of conserved active site cysteines and asparagines. This enzyme requires an activating component, NrdG, a radical-SAM domain containing enzyme (TIGR02491). Together the two form an alpha-2/beta-2 heterodimer. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]


Pssm-ID: 274159 [Multi-domain]  Cd Length: 579  Bit Score: 503.40  E-value: 2.28e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  116 ENSNKNAVMVSTQRDLIAGEVSRDLTRRIVLPEKISRAHDEGILHFHDSDYFIQPMFNCCLINIGDMLDNGTVMHGKLIE 195
Cdd:TIGR02487   2 ENANMDSPTPSTQRKLIASEVSKDYALLHLLPKDIARAHLNGDIHIHDLDYALTLTTNCCLHDLRNLLKYGFRTGNIVSK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  196 SPKSFQVACTVMTQIIASVASAQYGGQS---VDIsHLGKYLRRSRDKFRKRLvesTQGSLSEKELNEILDARMKEELASG 272
Cdd:TIGR02487  82 PPKHIDVALNHIVNILQSLQNEQYGGQSfpeFDT-LLAPYIEKTNLKHRKVL---QQLQLLLFEATEYAARRTFTDVTQA 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  273 VQTIQYQINTLMTTNGQSPFVTLFLhldpKDEYIEENAQIIEEILKQRLEGIKNEAgvyvTPAFPKLVYVLDENNCLKGG 352
Cdd:TIGR02487 158 MQGPEYNPNTLHSAGGQTPFESIGY----GTETSKEGRMIAKALLDVRMEGDGKGE----PFIFPKIIFKVREGFNWDEP 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  353 KYDYLTELAVRCSIKRMYPDYISAKKMRENYEGNVfSPMGCRSFLVPWKDKDGHYKFEGRFNQGVVSINLPQIGIIAKGD 432
Cdd:TIGR02487 230 DPYDLFELAFECAAKRGYPYFLNLDPEDNVKEDVR-YPMGCRTFLSPNENGDGEESYIGRGNIGVTSINLPRIAYKSRGD 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  433 EDKFWKLLDERLELCREALMVRHNALKGIRSDVSPIHWQNGAIAR-LKKGETIDKLLENGysTLSLGYIGLYECTVAMKG 511
Cdd:TIGR02487 309 EEEFFEELDEYLEIAKEALEIRREYLKKMLAKDLPPMYSQGGWDGgNLLDESVEEILKSG--TNSIGFIGLNEALVALTG 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  512 CS-HTTPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDVREH 590
Cdd:TIGR02487 387 KHlHEEEEARELAIRILEFIRDKADEFKKETGLNYSVYATPAESLCGRFAKKDREEFGEIPGVTDKPYYTNSFHVPVYED 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  591 IDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVRFIYDN-IQYAEFNTKSDYCQVCGFDGEIkVNDnlewEC 669
Cdd:TIGR02487 467 VNLGEKIDIEAPFHPLTNGGHITYIELDEAIPDPEALKDITKKAMKNgIGYFGINPPVDVCEDCGYTGEG-LND----KC 541

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|.
gi 512627998  670 PQCHNKDqskMNVVRRTCGYLGE-NFWNVGKTKEIKSRVLH 709
Cdd:TIGR02487 542 PKCGSHD---IEVISRITGYLGPvENWNDGKQAEFKDRKKH 579
RNR_III cd01675
Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ...
 116-691 1.40e-157

Class III ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in strict or facultative anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). The class III enzyme from phage T4 consists of two subunits, this model covers the larger subunit which contains the active and allosteric sites.


Pssm-ID: 153084 [Multi-domain]  Cd Length: 555  Bit Score: 467.16  E-value: 1.40e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 116 ENSNKNAVMVSTQRDLIAGEVSRDLTRRIvLPEKISRAHDEGILHFHDSDYFiQPMFNCCLINIGDMLDNGTVMHGKLIE 195
Cdd:cd01675    1 ENANVDSSPGSTMKDLAAGIVKKYYLLKI-LPKEIARAHLNGDIHIHDLDYL-PLTPYCCGWDLRPLLEKGFTTGNGIIE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 196 SPKSFQVACTVMTQIIASVASAQYGGQS---VDIsHLGKYLRRSRDKFRKRLVEstqgslsekelNEILDArmkeelasg 272
Cdd:cd01675   79 PPKHLSSALGHIVNFLGTVQNEQAGGQAfpeFDT-YLAPFVRKDYLKYRLTATR-----------KEIKQA--------- 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 273 VQTIQYQINTLMTTNGQSPFVTLFLHLDPKD---------------EYIEENAQIIEEILKQRLEGIKNEAgvyvTPAFP 337
Cdd:cd01675  138 MQGFIYNLNTLSRRGGQTPFTNITLGLVCPKdlefegggepvftygDTDKEARMIQKAFLEVRLEGDAKGR----PFTFP 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 338 KLVYVLDENNcLKGGKYDyLTELAVRCSIKRMYPDYISAKkmRENYEGNVFSPMGCRSFLVPWKDKDGHYKFE---GRFN 414
Cdd:cd01675  214 IPTFNVTEGF-NLDPNYD-LKELAFECAAKRGYPYFLNFD--NSDNVPGDVRAMGCRLFLDKNELKRGGGLEGsgdGTGN 289

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 415 QGVVSINLPQIGIIAKGDEDKFWKLLDERLELCREALMVRHNALKGIRSDVSPIHWQNGAIARLKkgetidkLLENGYST 494
Cdd:cd01675  290 IGVVTINLPRIAYEARGDEEKFFELLDEYLELAKDALEIRRKRLKEALARGLPPLYQEGLGGGKL-------LFILKRHT 362

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 495 LSLGYIGLYECTVAMKGCSH-TTPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRFARIDKERFGT-IKD 572
Cdd:cd01675  363 LTIGFIGLNEAAEALTGKGIgESEEAREFGIRILEHIRERADEFKEETGLLYSVEATPAESLAYRFAKKDRKKYGDiIPG 442

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 573 ITDKGYYTNSYHVDVREHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVRFIYDN-IQYAEFNTKSDYCQ 651
Cdd:cd01675  443 VTDKPYYTNSFHVPVYEDIDPFEKIDIEAKLHPLTTGGHILHIELGEAKPNPEALEALVKKAAKRgVIYFGINTPIDICN 522

                        570       580       590       600
                 ....*....|....*....|....*....|....*....|
gi 512627998 652 VCGFDGEIKVNdnlewECPQCHNKDqskMNVVRRTCGYLG 691
Cdd:cd01675  523 DCGYIGEGEGF-----KCPKCGSED---VEVISRITGYLG 554
PRK07111 PRK07111
anaerobic ribonucleoside triphosphate reductase; Provisional
 1-710 5.06e-130

anaerobic ribonucleoside triphosphate reductase; Provisional


Pssm-ID: 235937 [Multi-domain]  Cd Length: 735  Bit Score: 402.02  E-value: 5.06e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   1 MGMQVIKRDGSTVSFDRHKIVVAIQKANKAV--EEGERLPESDIDTIASFVEGKKRKRFLVEDIQDMVEKQIMNRGRYEL 78
Cdd:PRK07111   1 MMLYIVKRDGREVPFDEEKITNAIFKAAEAVggELDESEAIELTQKVIKYLEEKYKEEVTVEDIQDLVEKVLIENGHAET 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  79 AKAYIIYRYNRALVRKANTtdeSILSLISNKNKDVMEENSNKNAVMVSTQRDLIAGEVSRDLTRRIVLPEKISRAHDEGI 158
Cdd:PRK07111  81 AKAYILYRAERTRIREIKS---DLMKAIEEIGNDTDRENANVSGNTPSGKMLRIASESNKDYYNLYLLPKELAKAHENGD 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 159 LHFHDSDYFIQPMfNCCLINIGDMLDNG-TVMHGkLIESPKSFQVACTVMTQIIASVASAQYGGQSV---DiSHLGKYLR 234
Cdd:PRK07111 158 IHIHDLDFYNLTT-TCLQIDLKKLLERGfNTGHG-YIREPKRIESAAALACIILQSNQNDMHGGQSIpnfD-NDMAPFVE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 235 RSRDKFRKRLVESTQGSLSEKELNEILDARMKEELASGVQTIQ-------------------------------YQINTL 283
Cdd:PRK07111 235 KTFRRHRKEILEKLLELGVGEEVDEKESLNEEEELLLLLLALDfniakkaqekadelaeketrkrtyqamegfiHNLNTM 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 284 MTTNG-QSPFVTLFLHLDPKdeyiEENAQIIEEILKQRLEGI-KNEagvyvTPAFPKLVYVLDEN-NCLKGGKYDYLTEL 360
Cdd:PRK07111 315 HSRAGaQVPFSSINYGTDTS----PEGRMVCENLLLATEKGLgKGE-----TPIFPIQIFRVKEGvNYNEEDPNYDLFKL 385

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 361 AVRCSIKRMYPDY--ISA-------KKMRENYEgnvFSPMGCRSFLVpwKDKDGHYKFEGRFNQGVVSINLPQIGIIAKG 431
Cdd:PRK07111 386 ACRVAAKRLFPNFsfLDApfnkeyyDKGRPPTE---VATMGCRTRVM--SNVNGEEGTKGRGNLSFTTINLPRLAIEAKK 460

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 432 DEDKFWKLLDERLELCREALMVRHNALKGIRSDVSPIHWQNGAI---ARLKKGETIDKLLENGysTLSLGYIGLYECTVA 508
Cdd:PRK07111 461 DIDKFFELLDERLELAIEQLLHRYEVQKTLKVKDFPFLMGQGLWkgsENLGPDDSIEPVLKQG--TLGIGFIGLAETLVA 538

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 509 MKGCSH-TTPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRFARIDKERFGTIKDITDKGYYTNSYHVDV 587
Cdd:PRK07111 539 LTGKHHgESEEAQELGLKIVSHMRDFCDEYKEEYKLNYSLLATPAEGLSGRFIKMDRKKFGEIKGVTDKEYYTNSFHVPV 618

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 588 REHIDAFSKFKFENQFQPISTGGCISYVEIPN-MKKNPTAVEDLVRFIYD-NIQYAEFNTKSDYCQVCGFDGEIkvNDnl 665
Cdd:PRK07111 619 YYPISIFEKIEIEAPYHKLTNGGHISYVELDGdPSKNVEAFEIIVKAMKNtNIGYGSINHPVDRCPVCGYLGVI--ED-- 694

                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....*.
gi 512627998 666 ewECPQCHNKDQSKmnvVRRTCGYLGE-NFWNVGKTKEIKSRVLHL 710
Cdd:PRK07111 695 --KCPKCGSTNIQR---IRRITGYLGTlDRFNSAKKAERRDRVKHG 735
PRK14704 PRK14704
anaerobic ribonucleoside triphosphate reductase; Provisional
 109-710 9.26e-79

anaerobic ribonucleoside triphosphate reductase; Provisional


Pssm-ID: 184798 [Multi-domain]  Cd Length: 618  Bit Score: 263.97  E-value: 9.26e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 109 KNKDVMEENSNKNAVMVSTQRDLIAGEVSRDLTRRIVLPEKISRAHDEGILHFHDSDYFIQPMFNCCLINIGDMLDNG-T 187
Cdd:PRK14704  22 NEQDLMQENANVDGRSPMGVMGTFASESAKYYAVENLLSDQVKKAINENILYPHDLDFYATGTTTCSQIPLAQMLANGfH 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 188 VMHGKlIESPKSFQVACTVMTQIIASVASAQYGGQS-----VDishLGKYLRRSRDKFRKRLvesTQGSLSEKELNEILD 262
Cdd:PRK14704 102 TGHGH-MRQPQDIKSALALSSIIFQANQNMQHGGQSfalfdVD---LAPYVRKTVERHKKRL---QSYPLTKEQIEEFAW 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 263 ARMKEELASGVQTIQYQINTLMT-TNGQSPFVTLFLHLDPKdeyiEENAQIIEEILKQRLEGIKNEAgvyvTPAFPKLVY 341
Cdd:PRK14704 175 KETENDTYQACEAFIHNSNSMHSrGGGQVPFISINYGTDTS----KEGRLLIKQLLKATQAGLGKGE----TPIFPIQIF 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 342 VLDENNCLKGGKYDY-LTELAVRCSIKRMYPDY--ISAKKMRENYEGNVFSP---MGCRSFLVpwKDKDGHYKFEGRFNQ 415
Cdd:PRK14704 247 KMKKGVNFEESDPNYdLFELALETTAERLFPNFsfLDAPFNAVHYDGRPESEvcyMGCRTRVM--SNIHGEETAIGRGNL 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 416 GVVSINLPQIGIIAkGDEDKFWKLLDERLELCREALMVRHNALKGIRSD-----VSPIHWQNGAiaRLKKGETIDKLLEN 490
Cdd:PRK14704 325 SFTSINLVKLALIS-GSKEAFFEALNYYLDLGIKQLLERFEYQCTKRARdfrflYSQGVWRGGE--KLQPEDSVASILKQ 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 491 GysTLSLGYIGLYECTVAMKGCSHTTPEG-EEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRFARIDKERFGT 569
Cdd:PRK14704 402 G--TLSLGFIGLAECLVALTGKHHGEDEEsWKLGYEIISFMRDRMDKATEEHELNFSVIATPAEGLSGKFVKKDREEFGV 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 570 IKDITDKGYYTNSYHVDVREHIDAFSKFKFENQFQPISTGGCISYVEIP-NMKKNPTAVEDLVRFIYDN-IQYAEFNTKS 647
Cdd:PRK14704 480 ISGITNHNYYTNSFHIPVYYNIQAINKIRLEGPFHALCNGGHITYIELDgAAMHNKKALKQIVQAMAEHgVGYGSINHPV 559

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 512627998 648 DYCQVCGFDGEIkvndnlEWECPQCHNKDQSKMNVVRRTCGYLGENF--WNVGKTKEIKSRVLHL 710
Cdd:PRK14704 560 DRCKCCSYHGVI------GNECPSCGNEDEANIERIRRITGYLVGDMskWNSAKRSEEMDRVKHK 618
PRK08270 PRK08270
ribonucleoside triphosphate reductase;
1-675 6.61e-55

ribonucleoside triphosphate reductase;


Pssm-ID: 236212 [Multi-domain]  Cd Length: 656  Bit Score: 199.30  E-value: 6.61e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   1 MGMQVIKRDGSTVSFDRHKIVVAIQKANKAVEEGERlpeSDIDTIASFVEGK--KRKRFLVEDIQDMVEKQIMNRGRYEL 78
Cdd:PRK08270   1 MPTKIIKRDGRIVPFDAEKITEAIAKAFKATGEFDP---SEAERLALRVIEKleDEDIPSVEEIQDIVEKVLIEAGYFKT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  79 AKAYIIYRYNRALVRKANTTDESILSLISN--KNKD--VMEeNSNKNavmVSTQrDLI---AGEVSRDLTRRIVLPEKIS 151
Cdd:PRK08270  78 AKAYILYREQHARLRNDKKTLLDVEDTVDEylDREDwrVNE-NSNMG---YSLQ-GLIlniSGKVTANYWLNKVYPPEIG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 152 RAHDEGILHFHD----SDYfiqpmfnCCLINIGDMLDNG-TVMHGKlIES--PKSFQVACTvmtQIIASVASAQ---YGG 221
Cdd:PRK08270 153 EAHRNGDLHIHDldmlSGY-------CAGWSLRDLLLEGfNGVPGK-VESkpPKHFRSALG---QIVNFLGTLQnewAGA 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 222 Q---SVDiSHLGKYLRRsrDKfrkrlvestqgsLSEKELneildarmkeelasgVQTIQ---YQINTLMTTNGQSPFVTL 295
Cdd:PRK08270 222 QafsSFD-TYLAPFVRK--DG------------LSYKEV---------------KQAIQefvFNLNVPSRWGFQTPFTNL 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 296 FLHLDPKDEYIEENAQIIEEILK------QR-------------LEGIKNEAG------VY-VTPAFPklvyvLDENNcl 349
Cdd:PRK08270 272 TFDLTVPEDLKDQPVIIGGEEMDftygdfQKemdminrafievmLEGDANGRVftfpipTYnITKDFD-----WDSEN-- 344

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 350 kggkYDYLTELAVRCSIkrmyPdYISakkmreNYEGNVFSP-----MGCRSFLvpwkD-----KDGHykfeGRFNQ---- 415
Cdd:PRK08270 345 ----ADLLFEMTAKYGL----P-YFQ------NFINSDLKPedvrsMCCRLQL----DlrelrKRGG----GLFGSaelt 401

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 416 ---GVVSINLPQIGIIAKgDEDKFWKLLDERLELCREALmvrhnalkgirsdvspihwqngaiarLKKGETIDKLLENG- 491
Cdd:PRK08270 402 gsiGVVTINLPRLGYLSK-DEEEFFARLDELMDLAKDSL--------------------------EIKRKVIERLTDKGl 454

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 492 --YSTLSLGY----------IGLYECTVAMKGCSHTTPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRF 559
Cdd:PRK08270 455 ypYTKRYLGTlrnhfstiglNGMNEACLNFLGKDITTEEGRAFALRVLDHMRERLVEFQEETGNLYNLEATPAEGTTYRL 534

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 560 ARIDKERFGTIkdIT----DKGYYTNSYHVDVREHIDAFSKFKFENQFQPISTGGCISYVEIPNMKKNPTAVEDLVRFIY 635
Cdd:PRK08270 535 AKEDKKRYPDI--ITagtdEEPYYTNSTQLPVGYTDDPFEALELQDELQTKYTGGTVFHLYLGEAISDAEACKKLVKKAL 612

                        730       740       750       760
                 ....*....|....*....|....*....|....*....|...
gi 512627998 636 DN--IQYAEFNTKSDYCQVCGF-DGEikvndnlEWECPQCHNK 675
Cdd:PRK08270 613 ENyrLPYITITPTFSICPKHGYlSGE-------HEFCPKCGEE 648
Gly_radical pfam01228
Glycine radical;
587-694 1.51e-24

Glycine radical;


Pssm-ID: 426140 [Multi-domain]  Cd Length: 106  Bit Score: 98.39  E-value: 1.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998  587 VREHIDAFSKFKFENQFQPISTGGCISY-VEIPNMKKNPTAVEDLVRFiYDNIQYAEFNTKSDYCQVCGFDGEIKVNDNl 665
Cdd:pfam01228   1 VAPGISPSHGADFEGPTAVLNSVGKIDYeVELDGISLNQKFLPAVLGY-YDEEGYANLNTLIDTYFEGGHHLQFNVVDR- 78

                          90       100
                  ....*....|....*....|....*....
gi 512627998  666 eWECPQCHNKDQSKMNVVRRTCGYLGeNF 694
Cdd:pfam01228  79 -ETLPDAQKHPEKYPDLTVRVSGYSA-NF 105
RNR_PFL cd00576
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ...
 147-647 7.86e-22

Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.


Pssm-ID: 153083 [Multi-domain]  Cd Length: 401  Bit Score: 98.37  E-value: 7.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 147 PEKISRAHDEGILHFHDSDYfiqPMFNCCLINIGDMLDNGTVMhgkLIESPKSFQVACTVMTQIIASVASAQYGGqSVDI 226
Cdd:cd00576    1 AERIYEAVKSGVITVGRPDL---PFTGCVLVDYGDSLDPGIKG---VNETAKSINEAIQKTYQIIALAASNQNGG-GVSF 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 227 SHLGKYLrRSRDKFRKRLvestqGSLSEKELNEILDArmkeelasgvqtIQYQINTLMTTNGQSPFVTLFLHLDPKDEYI 306
Cdd:cd00576   74 ARASSIL-SPYGSRDYAK-----GSGTETDAVEAADA------------FNLALKEVGQGNGRTGAATGFIGGVHKGKGD 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 307 EenaqIIEEILKQRlegIKNEAGVYVTPaFPKLVYVLDENNCLKGGKYDYLTELAVRCSIKRMYPDYISAKkmrenyegn 386
Cdd:cd00576  136 K----ISQEFLNLA---LANGGEGIPLN-FPNLSVRVSSDKPGILVKAVELKQLIAEEARKTGSPGIFNDE--------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 387 vfspmgcrsflvpwkdkdghykfegrfNQGVVSINLPQIGIIA-KGDEDKFWKLLDERLELCREALMVRHNALKgirsdv 465
Cdd:cd00576  199 ---------------------------LCNLVSLNLARIMEKAiNGSMDVVLEELEELAFLAVRALDCVIDSHD------ 245

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 466 spihwqngaiarlkkgETIDKLLE--NGYSTLSLGYIGLYECTVAMKGCSHTTPEGEEFAMRVMKHLNAACKKWRAESGL 543
Cdd:cd00576  246 ----------------ERIPTIELggDERRTVGLGIAGVADLLIKLGLEKVGDPEADDLAAELVDQLKKHLVKATNERGF 309

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 544 GFSLYGTPAESlcyrfaridkerfgtikdITDKGYYTNSYHVD-------VREHIDAFSKFKFENQFQPISTGGCISYVE 616
Cdd:cd00576  310 NFLLGLSPSES------------------NSSGAPATNGVSPSrg*iaivLNGDIGPEESLASVAILQFYADNGISDTIT 371

                        490       500       510
                 ....*....|....*....|....*....|.
gi 512627998 617 IPNMKKNPTAVEDLVRfiydniQYAEFNTKS 647
Cdd:cd00576  372 IPDSATNLDQLLAVID------GAAAIKTTH 396
ATP-cone pfam03477
ATP cone domain;
3-89 1.10e-21

ATP cone domain;


Pssm-ID: 397513 [Multi-domain]  Cd Length: 86  Bit Score: 89.63  E-value: 1.10e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998    3 MQVIKRDGSTVSFDRHKIVVAIQKANKAVEEgerlpesDIDTIASFVEGKKRKRFL----VEDIQDMVEKQIMNRGRYEL 78
Cdd:pfam03477   1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPD-------QADELASEVEEELEKSLEdgisTEEIQDLVEKTLAEHPDYAV 73

                          90
                  ....*....|.
gi 512627998   79 AKAYIIYRYNR 89
Cdd:pfam03477  74 ARAYILYRNLR 84
PRK12364 PRK12364
ribonucleoside-diphosphate reductase subunit alpha;
3-112 8.20e-18

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 237077 [Multi-domain]  Cd Length: 842  Bit Score: 87.88  E-value: 8.20e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   3 MQVIKRDGSTVSFDRHKIVVAIQKANKAVeeGERLPESDIDTIASFVEgkkrkRFL-----------VEDIQDMVEKQIM 71
Cdd:PRK12364   1 MEIIKRNGTTEPYDREKIEVAIRKAFASV--GKPISDEIIYSLVAEVE-----RFIkekypnghnvsVEEIQDLVEKTLM 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 512627998  72 NRGRYELAKAYIIYRYNRALVRKA------NTTDESILSLISNKNKD 112
Cdd:PRK12364  74 EHGHYAEVKSYILYRAQRTEKRKAreqiikFFDDDTVLGVLKEIQKD 120
PRK07207 PRK07207
ribonucleoside-diphosphate reductase subunit alpha;
1-100 9.92e-15

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 235966 [Multi-domain]  Cd Length: 965  Bit Score: 78.08  E-value: 9.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   1 MGMQVIKRDGSTVSFDRHKIVVAIQKANKAVEEGERLPESDI-DTIA----SFVEGKKRKR-----FLVEDIQDMVEKQI 70
Cdd:PRK07207  32 ADYKVIRRNGSVVPFEPSKIAVAMTKAFLAVEGGQAAASARVrETVEqlteQVVRALVRRRpsggtFHIEDIQDQVELAL 111

                         90       100       110
                 ....*....|....*....|....*....|
gi 512627998  71 MNRGRYELAKAYIIYRYNRALVRKANTTDE 100
Cdd:PRK07207 112 MRSGEHKVARAYVLYREKRAQERAAEAEAA 141
PRK08579 PRK08579
anaerobic ribonucleoside triphosphate reductase; Provisional
 416-707 4.41e-14

anaerobic ribonucleoside triphosphate reductase; Provisional


Pssm-ID: 236303 [Multi-domain]  Cd Length: 625  Bit Score: 75.56  E-value: 4.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 416 GVVSINLPQIGIIAKGDEDKFWKLLDERLELCREALM-VRHNALKGIRSD---VSPIHwqngaiarlkkgetidKLLENG 491
Cdd:PRK08579 337 NVTTVNLPRIALEARGDDDKFWELYEERLELVRITLDwFRERYVKLLKTYpemYSMIK----------------EYLEEF 400

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 492 YST--LSLGYIGLYECTVAMKGCSHTTPEGE----EFAMRVMK----HLNAACKKWRAESGLGFSLYGTPAESLCYRFAR 561
Cdd:PRK08579 401 PSShfNTIGIIGLPEAAAIYLGEPKLWTEGSrrdwLEAAELMKkmveFAVEKAREWMKETGTPWNVEEVPGESAAAKLAI 480

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 562 IDKERFGTIKDITDKG---YYTNS---YHVDvrehIDAFSKFKFENQFQPISTGGCISYV---EIPnmkkNPTAVEDLVR 632
Cdd:PRK08579 481 KDLKLFPELREYLSDPenpIYSTSiapYYGP----LELWDRIEIEEKVQQEFTGGVMMHIflgEEP----DPEALAKLTK 552

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 512627998 633 FIYD-NIQYAEFNTKSDYCQVCGfdgeiKVNDNLEWECPQCHNKDqskMNVVRRTCGYLG--ENfWNVGKTKEIKSRV 707
Cdd:PRK08579 553 RIMNtKLVYWSYTPAITVCNKCG-----RSTTGLYTRCPRCGSED---VEVWSRIIGYYRplKN-WNPYRKKEFWLRK 621
PRK12365 PRK12365
ribonucleoside-diphosphate reductase subunit alpha;
3-117 8.65e-14

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 171440 [Multi-domain]  Cd Length: 1046  Bit Score: 75.37  E-value: 8.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998    3 MQVIKRDGSTVSFDRHKIVVAIQKANKAVEEGERLPESDI--------DTIASFVEGK--KRKRFLVEDIQDMVEKQIMN 72
Cdd:PRK12365  118 LSVIRRDGTVVHFNPMKISAALEKAFRATDKIEGMTPSSVleeinaltQNIVEEILECcsQEDRIDIEKIQDIVEQQLMV 197

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 512627998   73 RGRYELAKAYIIYRYNRALVRKANTTDESILSLISNKNKDVMEEN 117
Cdd:PRK12365  198 VGHYDVAKNYILYREARARVRDNKEEDGSTEKTIAEEAYEVLSKD 242
PRK06406 PRK06406
vitamin B12-dependent ribonucleotide reductase;
1-95 4.12e-13

vitamin B12-dependent ribonucleotide reductase;


Pssm-ID: 235796 [Multi-domain]  Cd Length: 771  Bit Score: 72.96  E-value: 4.12e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   1 MGMQVIKRDGSTVSFDRHKIVVAIQKANKAVEEGErlpESDIDTIASFVEG--KKRKRFLVEDIQDMVEKQIM-----NR 73
Cdd:PRK06406   3 MVKEVIKRDGTVVPFDKKKIAMAIYKAMLSVKNGS---MEDAEELTDKVVErlKKYERPTVEQIQDIVEKVLMtkkinGK 79

                         90       100
                 ....*....|....*....|..
gi 512627998  74 GRYELAKAYIIYRYNRALVRKA 95
Cdd:PRK06406  80 DFTDVAKSYILYREKRRKIREE 101
PRK08332 PRK08332
vitamin B12-dependent ribonucleotide reductase;
4-148 9.21e-12

vitamin B12-dependent ribonucleotide reductase;


Pssm-ID: 181392 [Multi-domain]  Cd Length: 1740  Bit Score: 69.02  E-value: 9.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998    4 QVIKRDGSTVSFDRHKIVVAIQKA--NKAVEEGERLPE---SDIDTIASFVEGKKRKrflVEDIQDMVEKQIMNRGRYEL 78
Cdd:PRK08332    5 KVMKRDGRIVPFDESRIRWAVQRAmwEVGVRDEKKLDEvvkRIVQRINELYDGKIPH---IENIQDIVELELMRAGLFEV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   79 AKAYIIYRYNRALVRkanttdESILSLISNKNKDVMEENSNKNAVMVSTQRDLIAG------EVSRDLTRRI----VLPE 148
Cdd:PRK08332   82 AKAYILYRKKKAEIR------EEKKRILNKKELDEIDKRFSINALRVLASRYLKKDengniiESPRELFERVailaVIPD 155
PRK08271 PRK08271
anaerobic ribonucleoside triphosphate reductase; Provisional
 411-709 2.46e-09

anaerobic ribonucleoside triphosphate reductase; Provisional


Pssm-ID: 181342 [Multi-domain]  Cd Length: 623  Bit Score: 60.41  E-value: 2.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 411 GRFNqgVVSINLPQIGIIAKgDEDKFWKLLDERLELCREALMVRHNALKG-IRSDVSPIhWQNGAIarlkkgeTIDKLle 489
Cdd:PRK08271 349 GSIN--VITINLPRIAQEAR-DRDDFLEILRERVDKIHKYQLAYREIMEErIAAGMLPL-YDAGFI-------SLDKQ-- 415

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 490 ngYSTLslGYIGLYECTVAMKGCSHTTPEGEEFAMRVMKHLNAACKKWRAESGLGFSLYGTPAESLCYRFARIDKE-RFG 568
Cdd:PRK08271 416 --FLTI--GINGMVEAAEFMGLTVGYNEEYKDFVQEVLKVIYEANEKASKEYGFTFNTEFVPAENLGVKLAKWDREdGYG 491

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998 569 TIKDItdkgYYTNSYHVDVrEHIDAFSKFKFE-NQFQPISTGGCISYVeipNMKKNPTAVE--DLVRFIYD-NIQYAEFN 644
Cdd:PRK08271 492 VPRQC----YNSYSYVVED-ANTDALDKFKLHgKELDKYLSGGSALHL---NLDERLSEEGyrKLLNIAAKtGCNYFAFN 563

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512627998 645 TKSDYCQVCG-FDgeikvNDNLEwECPQCHNKDQSKMNvvrRTCGYLGE-NFWNVGKTKEIKSRVLH 709
Cdd:PRK08271 564 VKITICNDCHhID-----KRTGK-RCPICGSENIDYYT---RVIGYLKRvSAFSKVRQKEYPRRHYH 621
PRK12365 PRK12365
ribonucleoside-diphosphate reductase subunit alpha;
5-94 5.81e-07

ribonucleoside-diphosphate reductase subunit alpha;


Pssm-ID: 171440 [Multi-domain]  Cd Length: 1046  Bit Score: 53.03  E-value: 5.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998    5 VIKRDGSTVSFDRHKIVVAIQKA---NKAVEEGERLPESDIDTIASF-------VEGKKR--KRFLVEDIQDMVEKQIMN 72
Cdd:PRK12365   11 IVKRNGMFVPFNQNRIFQALEAAfrdTRSLEDHSPLPEDLESSIRSIthqvvkeVVQKITegQVVTVERIQDMVESQLYV 90

                          90       100
                  ....*....|....*....|..
gi 512627998   73 RGRYELAKAYIIYRYNRALVRK 94
Cdd:PRK12365   91 NGLQDVARDYIVYRDDRKAHRK 112
NrdR COG1327
Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains [Transcription];
4-86 1.23e-03

Transcriptional regulator NrdR, contains Zn-ribbon and ATP-cone domains [Transcription];


Pssm-ID: 440938 [Multi-domain]  Cd Length: 153  Bit Score: 40.06  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512627998   4 QVIKRDGSTVSFDRHKIVVAIQKA-NKaveegeR-LPESDIDTIASFVEGKKRKRFLVE----DIQDMVekqiMNrgryE 77
Cdd:COG1327   50 MVIKKDGRREPFDREKLLRGLLRAcEK------RpVSAEQIEAAVDRIERELRASGEREvpsrEIGELV----ME----E 115

                         90
                 ....*....|....*..
gi 512627998  78 LAK----AYI----IYR 86
Cdd:COG1327  116 LKKldevAYVrfasVYR 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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