|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
61-439 |
1.96e-53 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 182.66 E-value: 1.96e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 61 AGMMIVGDAIFQTGVAQKMGVAIGKlRIVQNERIFTVVVVTICTFMSAFMSDSGCIAMWMPIIAAVAAGSRGKIRSK--- 137
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLK-RFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKfgs 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 138 MVIMPAGIACIVGGATTLVGSTSQNTANSFLMQTAGYEMGMgvFDVTRIMWIVDIVMVLYFATIGYtitkKTLKPGSPHF 217
Cdd:COG0471 80 ALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISF--FEWMLVGLPVALVGLLLLWLVLY----RLLPPEIKEV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 218 DDGNQYAAAPCDELDGVgipqvpKKKQVISVFTLGICIVGFILCGFRPfsayLNIANVALIGATILFMTKTISFEKTLHE 297
Cdd:COG0471 154 PGSKEVIREELAELGPL------SRREKIALAIFALTVLLWITGSLHG----IPIAVVALLGAVLLLLTGVLTWKDAYKS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 298 LNWGVLLTVGAITTLGTGLEKTGAGELIASSILDFFGGenASLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALK 377
Cdd:COG0471 224 IPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGG--LSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQA 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512628489 378 MGLSPVPFIILIAVASNMAIATPIGTPVNMQIL-PAGYKFSDYVKIGGPLWLLFMIVVCLTAP 439
Cdd:COG0471 302 LGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYgSGYYKFKDFLKVGLPLNLIGLVVLLLLGP 364
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
8-442 |
6.58e-46 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 163.14 E-value: 6.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 8 IVIVAVTMVLFITRAFPMAVTAVLCSLAMGImLPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGVAIGKLR 87
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVL-LGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 88 IVQNERIFTVVVVtICTFMSAFMSDSGCIAMWMPIIAAVAAgsRGKIRSKMVIMPAGIACIVGGATTLVGsTSQNTANSF 167
Cdd:cd01115 80 GKGERRLLLLLML-VTAFLSAFMSNTATVAIMLPVALGLAA--KLDISPSRLLMPLAFAASIGGMLTLIG-TPPNLVASG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 168 LMQTAGYEmGMGVFDVTRIMWIVDIVMVLYFATIgytitkktlkpgsphfddgnqyaaapcdeldgvgipqvpkkkqvis 247
Cdd:cd01115 156 YLESLGGQ-GFSFFEFTPIGLPLLIIGLLYLWFI---------------------------------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 248 VFTLGICIVGFILCGFRPFSAYLNIANVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIAS 327
Cdd:cd01115 189 FRLAVLIITIVLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAE 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 328 SILDFFGGenASLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASNMAIATPIGTPVNM 407
Cdd:cd01115 269 ALISLLGG--LPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNA 346
|
410 420 430
....*....|....*....|....*....|....*.
gi 512628489 408 QILPAG-YKFSDYVKIGGPLWLLFMIVVCLTAPSLL 442
Cdd:cd01115 347 IVLGPGgYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
8-437 |
4.12e-23 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 100.88 E-value: 4.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 8 IVIVAVTMVLFITRAFPMAVTAVLCSLAMGIMLP---SVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGVAIG 84
Cdd:TIGR00785 14 LAIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGvlsAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 85 KLRIVQNERIFTVVVVTICTFMSAFMSDSGCI-AMWMPIIAAVAA-------GSRGKIRSKMVIMPAGIACIvGGATTLV 156
Cdd:TIGR00785 94 GKMGGTTLGLGYFLVFLETLLAPMWPSNTARAgGILLPIIKSLLPllgskpeKSPRKIGKYLMLGIAYSASI-GSSGFLT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 157 GSTSQNTANSFLMQTAGYEMGMgvFDVTRIMWIVDIVMVLYFATIGYTITKKTLKPGsphfDDGNQYAAapcDELDGVGI 236
Cdd:TIGR00785 173 GSAPNALAAGILSKILGIQISW--GDWFLAGLPLGIILLLLVPLLLYVLFPPELKLK----DEVDLWAK---EELEEMGP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 237 pqvpkkkQVISVFTLGICIVGFILCGFRPFSAYLNIANVALIGATILFMTKTISFEKTLHEL-NWGVLLTVGAITTLGTG 315
Cdd:TIGR00785 244 -------MSFREKALLGIFLLALLLWIFGGSLGINASVVALLAVVLMLFLGIVTWKDIQKNKvAWNTLILFGGLIGLAGG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 316 LEKTGAGELIASSILDFFGGeNASLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASN- 394
Cdd:TIGR00785 317 LKKSGFIKWFSEKLVGILDG-LSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASl 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 512628489 395 MAIATPIGTPVNMQILPAGY-KFSDYVKIGGPLWLLFMIVVCLT 437
Cdd:TIGR00785 396 MGFLTPYATPPNAIAYGSGYvKIKDMWRVGAIIGIVGLIVLLLV 439
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
15-392 |
2.57e-20 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 91.60 E-value: 2.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 15 MVLFITRAFPMAVTAVLCSLAMgIMLPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGVAIgkLRIVQNERI 94
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLL-VLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKL--LRLAGGKPR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 95 FTVVVVTICT-FMSAFMSDSGCIAMWMPIIAAVAAgsRGKIRSKMVIMPAGIACIVGGATTLVGsTSQNTANSFLMQTAG 173
Cdd:pfam03600 78 RLLVALMLATaLLSAFLSNDGTVLIMIPIVLALAR--RLGLPPSPLLIALAFAANIGGTATPIG-DPPNIIIASALGLSF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 174 YEMGMGVFDVTRIMWIVdiVMVLYFATIGYTITKKTLKPGSphfddgnqyaaapcDELDGVGIPQVPKKKQVISVFTLGI 253
Cdd:pfam03600 155 GDFGFFMFPPVGVALLL--VGLLPLLLIFRKLLPVRKEEEA--------------ELEELRKRAIKDKLLLAISALVLAL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 254 CIVGFILcgfrpfsaylnIANVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIASSILDFF 333
Cdd:pfam03600 219 VILGFLL-----------LSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 334 GgenasLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPV-PFIILIAVA 392
Cdd:pfam03600 288 G-----LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPdPLAWALAVG 342
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
61-439 |
1.96e-53 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 182.66 E-value: 1.96e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 61 AGMMIVGDAIFQTGVAQKMGVAIGKlRIVQNERIFTVVVVTICTFMSAFMSDSGCIAMWMPIIAAVAAGSRGKIRSK--- 137
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLK-RFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKfgs 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 138 MVIMPAGIACIVGGATTLVGSTSQNTANSFLMQTAGYEMGMgvFDVTRIMWIVDIVMVLYFATIGYtitkKTLKPGSPHF 217
Cdd:COG0471 80 ALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISF--FEWMLVGLPVALVGLLLLWLVLY----RLLPPEIKEV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 218 DDGNQYAAAPCDELDGVgipqvpKKKQVISVFTLGICIVGFILCGFRPfsayLNIANVALIGATILFMTKTISFEKTLHE 297
Cdd:COG0471 154 PGSKEVIREELAELGPL------SRREKIALAIFALTVLLWITGSLHG----IPIAVVALLGAVLLLLTGVLTWKDAYKS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 298 LNWGVLLTVGAITTLGTGLEKTGAGELIASSILDFFGGenASLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALK 377
Cdd:COG0471 224 IPWGVLLLFGGGLALGAALEKTGLAAWLADALLPLLGG--LSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQA 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 512628489 378 MGLSPVPFIILIAVASNMAIATPIGTPVNMQIL-PAGYKFSDYVKIGGPLWLLFMIVVCLTAP 439
Cdd:COG0471 302 LGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYgSGYYKFKDFLKVGLPLNLIGLVVLLLLGP 364
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
8-442 |
6.58e-46 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 163.14 E-value: 6.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 8 IVIVAVTMVLFITRAFPMAVTAVLCSLAMGImLPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGVAIGKLR 87
Cdd:cd01115 1 LAILVFAAVLFVTEALPLDVTALLVPVLLVL-LGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 88 IVQNERIFTVVVVtICTFMSAFMSDSGCIAMWMPIIAAVAAgsRGKIRSKMVIMPAGIACIVGGATTLVGsTSQNTANSF 167
Cdd:cd01115 80 GKGERRLLLLLML-VTAFLSAFMSNTATVAIMLPVALGLAA--KLDISPSRLLMPLAFAASIGGMLTLIG-TPPNLVASG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 168 LMQTAGYEmGMGVFDVTRIMWIVDIVMVLYFATIgytitkktlkpgsphfddgnqyaaapcdeldgvgipqvpkkkqvis 247
Cdd:cd01115 156 YLESLGGQ-GFSFFEFTPIGLPLLIIGLLYLWFI---------------------------------------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 248 VFTLGICIVGFILCGFRPFSAYLNIANVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIAS 327
Cdd:cd01115 189 FRLAVLIITIVLLAALAAITGLLPVSVAIAIGAIVLVFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAE 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 328 SILDFFGGenASLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASNMAIATPIGTPVNM 407
Cdd:cd01115 269 ALISLLGG--LPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNA 346
|
410 420 430
....*....|....*....|....*....|....*.
gi 512628489 408 QILPAG-YKFSDYVKIGGPLWLLFMIVVCLTAPSLL 442
Cdd:cd01115 347 IVLGPGgYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
15-436 |
1.74e-29 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 118.51 E-value: 1.74e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 15 MVLFITRAFPMAVTAVLCSLAMgIMLPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGVAIgkLRIVQNERI 94
Cdd:cd00625 1 YVLIRPEKLPRAVVALLGAVLL-VLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKL--ARASKGSRR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 95 FTVVVVTICTFMSAFMSDSGCIAMWMPIIAAVAAGSRGKIRSKMvIMPAGIACIVGGATTLVGsTSQNTAnSFLMQTAGY 174
Cdd:cd00625 78 LLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSPPVPL-LLALAFAANIGGAATPIG-NPPNLI-IASLSGLGF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 175 EMGMGVFDVTRIMWIVDIVMVLYFATIGYTITKktlkpgsphfddgnqyaaapcDELDGVGIPQVPKKKQVISVFTLGIC 254
Cdd:cd00625 155 LDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLP---------------------DEDKLTVLAEPLPARPLLKKFLLLAL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 255 IVGFILCGFRPFSAYLNIANVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIASSILDFFG 334
Cdd:cd00625 214 LLLLLFVLLFFFLIPLGLIALLGALLLLLLLVRGLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVG 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 335 GenaSLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPL-----ALKMGLSPVPFIILIAVASNMAIATPIGTPVNMQI 409
Cdd:cd00625 294 L---PPLAALLLIGLLSALLSNFISNVPTVALLLPIAASLappepAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGV 370
|
410 420
....*....|....*....|....*..
gi 512628489 410 lpaGYKFSDYVKIGGPLWLLFMIVVCL 436
Cdd:cd00625 371 ---GISFGEFLKVGLPLTLLSLVVSLL 394
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
8-437 |
4.12e-23 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 100.88 E-value: 4.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 8 IVIVAVTMVLFITRAFPMAVTAVLCSLAMGIMLP---SVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGVAIG 84
Cdd:TIGR00785 14 LAIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGvlsAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 85 KLRIVQNERIFTVVVVTICTFMSAFMSDSGCI-AMWMPIIAAVAA-------GSRGKIRSKMVIMPAGIACIvGGATTLV 156
Cdd:TIGR00785 94 GKMGGTTLGLGYFLVFLETLLAPMWPSNTARAgGILLPIIKSLLPllgskpeKSPRKIGKYLMLGIAYSASI-GSSGFLT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 157 GSTSQNTANSFLMQTAGYEMGMgvFDVTRIMWIVDIVMVLYFATIGYTITKKTLKPGsphfDDGNQYAAapcDELDGVGI 236
Cdd:TIGR00785 173 GSAPNALAAGILSKILGIQISW--GDWFLAGLPLGIILLLLVPLLLYVLFPPELKLK----DEVDLWAK---EELEEMGP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 237 pqvpkkkQVISVFTLGICIVGFILCGFRPFSAYLNIANVALIGATILFMTKTISFEKTLHEL-NWGVLLTVGAITTLGTG 315
Cdd:TIGR00785 244 -------MSFREKALLGIFLLALLLWIFGGSLGINASVVALLAVVLMLFLGIVTWKDIQKNKvAWNTLILFGGLIGLAGG 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 316 LEKTGAGELIASSILDFFGGeNASLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASN- 394
Cdd:TIGR00785 317 LKKSGFIKWFSEKLVGILDG-LSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVASAQGIPLELLALALALSASl 395
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 512628489 395 MAIATPIGTPVNMQILPAGY-KFSDYVKIGGPLWLLFMIVVCLT 437
Cdd:TIGR00785 396 MGFLTPYATPPNAIAYGSGYvKIKDMWRVGAIIGIVGLIVLLLV 439
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
15-392 |
2.57e-20 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 91.60 E-value: 2.57e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 15 MVLFITRAFPMAVTAVLCSLAMgIMLPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGVAIgkLRIVQNERI 94
Cdd:pfam03600 1 YVLIITEKLPRDVVALLGAVLL-VLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKL--LRLAGGKPR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 95 FTVVVVTICT-FMSAFMSDSGCIAMWMPIIAAVAAgsRGKIRSKMVIMPAGIACIVGGATTLVGsTSQNTANSFLMQTAG 173
Cdd:pfam03600 78 RLLVALMLATaLLSAFLSNDGTVLIMIPIVLALAR--RLGLPPSPLLIALAFAANIGGTATPIG-DPPNIIIASALGLSF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 174 YEMGMGVFDVTRIMWIVdiVMVLYFATIGYTITKKTLKPGSphfddgnqyaaapcDELDGVGIPQVPKKKQVISVFTLGI 253
Cdd:pfam03600 155 GDFGFFMFPPVGVALLL--VGLLPLLLIFRKLLPVRKEEEA--------------ELEELRKRAIKDKLLLAISALVLAL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 254 CIVGFILcgfrpfsaylnIANVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIASSILDFF 333
Cdd:pfam03600 219 VILGFLL-----------LSVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 334 GgenasLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPV-PFIILIAVA 392
Cdd:pfam03600 288 G-----LLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPdPLAWALAVG 342
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
248-436 |
1.24e-17 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 84.41 E-value: 1.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 248 VFTLGICIVGFILCGFRPFSayLNIANVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIAS 327
Cdd:COG1055 3 ILALAIFVLTYLLIILEPRG--LNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 328 SILDFFGGenaSLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASNMA-IATPIGTPVN 406
Cdd:COG1055 81 KLARRAKG---SPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTN 157
|
170 180 190
....*....|....*....|....*....|.
gi 512628489 407 MQI-LPAGYKFSDYVKIGGPLWLLFMIVVCL 436
Cdd:COG1055 158 IMIaSAGGLSFLDFLANLFPPSLVSLLVTLL 188
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
4-433 |
6.58e-15 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 76.32 E-value: 6.58e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 4 TTLCIVIVAVTMVLFITR--AFPMAVTAVLCSLAMgIMLPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGV 81
Cdd:COG1055 2 MILALAIFVLTYLLIILEprGLNRAVAALLGAALL-LLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 82 AIGKLRIVQNERIFtVVVVTICTFMSAFMSDSGCIAMWMPIIAAVAAgsRGKIRSKMVIMPAGIACIVGGATTLVGstsq 161
Cdd:COG1055 81 KLARRAKGSPRRLL-WLLGLLTALLSAFLDNDTTALLLTPVVLAIAR--RLGLNPVPFLIAIVFAANIGGAATPIG---- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 162 NTANsfLMqtAGYEMGMGVFDVTRIMWIVDIVMVLYFATIGYTITKKTLKPGSPHFDDGNqyaaapcdeldgvgIPQVPK 241
Cdd:COG1055 154 NPTN--IM--IASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDLEDDPK--------------EAIKDR 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 242 KKQVISVFTLGICIVGFILCGFRPFSAYLnianVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGA 321
Cdd:COG1055 216 RLLRISLLVLALLLVGFVLHSFLGLPPAL----IALLGAAVLLLLARVDVREVLKKVDWSTLLFFIGLFVVVGGLENTGL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 322 GELIASSILDFFGGenaSLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMglSPVPFIILIAVASNMA-IATP 400
Cdd:COG1055 292 LDLLAELLASLTGG---NLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATG--NPEPLWLALALGATLGgNLTP 366
|
410 420 430
....*....|....*....|....*....|....*....
gi 512628489 401 IGTPVN---MQIL---PAGYKFSDYVKIGGPLWLLFMIV 433
Cdd:COG1055 367 IGSAANvivLGIAekkGIKISFGEFLKVGLPLTLLTLLI 405
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
270-443 |
3.51e-14 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 73.50 E-value: 3.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 270 LNIANVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIASSILDFFGGENASLTVVICVMfv 349
Cdd:pfam03600 9 LPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLA-- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 350 lGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASNMA-IATPIGTPVNMQILPA-GYKFSDYVKIGGPLW 427
Cdd:pfam03600 87 -TALLSAFLSNDGTVLIMIPIVLALARRLGLPPSPLLIALAFAANIGgTATPIGDPPNIIIASAlGLSFGDFGFFMFPPV 165
|
170
....*....|....*.
gi 512628489 428 LLFMIVVCLTAPSLLF 443
Cdd:pfam03600 166 GVALLLVGLLPLLLIF 181
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
253-443 |
3.40e-12 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 67.61 E-value: 3.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 253 ICIVGFILCGFrpFSAYLNIANVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIASSILDF 332
Cdd:cd01115 1 LAILVFAAVLF--VTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 333 FGGENASLtvvICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASNM-AIATPIGTPVNM---- 407
Cdd:cd01115 79 AGKGERRL---LLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPSRLLMPLAFAASIgGMLTLIGTPPNLvasg 155
|
170 180 190
....*....|....*....|....*....|....*....
gi 512628489 408 ---QILPAGYKFSDYVKIGGPLWLLFMIVVCLTAPSLLF 443
Cdd:cd01115 156 yleSLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAVL 194
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
2-438 |
9.12e-12 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 66.63 E-value: 9.12e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 2 SETTLCIVIVAVTMVLFITRAFPMAVTAVLCSLAMGIM---LPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQK 78
Cdd:pfam00939 28 SKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILigtLLAKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 79 mgVAIGKLRIVQNE-RIFTVVVVTICTFMSAFM----SDSGCIAmwMPIIAAVAA--------GSRGKIRSKMVIMPAGI 145
Cdd:pfam00939 108 --IALVLVKKMGKRtLGLGYGLVFSDLLLAPATpsntARAGGIV--FPIIMSLPPafgsdpekGSERRIGAYLMWTVYQS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 146 ACIvGGATTLVGSTSQNTANSFLMQTAGYEMGMGVFDVTRImwIVDIVMVLYFATIGYTITKktlkpgsPHFDDGNQYAA 225
Cdd:pfam00939 184 TSI-TSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAI--PPGVILLLLAPLLLYVLYP-------PEIKSVPDAKA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 226 APCDELDGVGiPQVPKKKQVISVFTLgiCIVGFILCGFRPFSAylniANVALIGATILFMTKTISFEKTLHE-LNWGVLL 304
Cdd:pfam00939 254 IAKTELKELG-PMTFREKALLGLFVL--LLLLWIFGGSLNIDA----TTVAIIGLALMLLLRILDWKDIVKNkGAWNTLI 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 305 TVGAITTLGTGLEKTGAGELIASSILDFFGGENASLTVVIcVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVP 384
Cdd:pfam00939 327 WLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFII-ILSLFYLSHYLFASATAHTAAMLPIFAAVAQAIPGAPPL 405
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 512628489 385 FIILIAVASN--MAIATPIGTPVNMQILPAGY-KFSDYVKIGGPLWLLFMIVVCLTA 438
Cdd:pfam00939 406 LAALLLGFAIslGGFLTPYGTGPGPIYFGSGYlKVKDWWRIGAILTIIGLLILLLLG 462
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
14-433 |
1.48e-10 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 62.65 E-value: 1.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 14 TMVLFITRAFPMAVTAVLCSLAM---GIMLPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGVAIGKLRIVQ 90
Cdd:cd01116 4 TYALIIFEKVHRTVAALAGALWLvilGLATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGR 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 91 NERIFtVVVVTICTFMSAFMSDSGCIAMWMPIIAAVAagSRGKIRSKMVIMPAGIACIVGGATTLVGstsqNTANSFLMQ 170
Cdd:cd01116 84 PWRLL-LLLGLLTAFLSAFLDNVTTVLLMVPVTIRLC--EVLGLNPVPVLISEVIAANIGGAATLIG----DPPNIMIGS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 171 TAGYEMgmgvFDVTRIMWIVDIVMVLYFATIGYTITKKTLKpgsphFDDGNQYAAAPCDELDGVGIPQVPKKkqviSVFT 250
Cdd:cd01116 157 AAGLTF----NDFLLHMLPSVVLALVVTFILLYFLYRNILK-----AREEDVLALAELEPKYPIKDKVLLLK----SLTI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 251 LGICIVGFILCGFRPFSaylnIANVALIGAT-ILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIASSI 329
Cdd:cd01116 224 LTLVIIGFVLHSPLGVS----LGWIALLGALlLLLLADKLDFEDVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 330 LDFFGGENASLTVVIcvMFVLGsFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASNMA-IATPIGTPVNM- 407
Cdd:cd01116 300 VGVILGRIAVAVILI--LWISA-LLSAFIDNIPVTATMIPIVKDLASQLGIPLLPLWWALALGACLGgNGTLIGASANVv 376
|
410 420 430
....*....|....*....|....*....|.
gi 512628489 408 ---QILPAGYKFS--DYVKIGGPLWLLFMIV 433
Cdd:cd01116 377 aagIAEQHGYKISfwEFLKVGFPIMLVSLIL 407
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
312-443 |
5.43e-09 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 57.47 E-value: 5.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 312 LGTGLEKTGAGELIASSILDFFGGenaSLTVVICVMFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGL-----SPVPFI 386
Cdd:COG0471 6 LAAALEKTGLGRRIALLLLKRFGG---SPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSekrskFGSALL 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 512628489 387 ILIAVASNM-AIATPIGTPVNM-------QILPAGYKFSDYVKIGGPLWLLFMIVVCLTAPSLLF 443
Cdd:COG0471 83 LPIAFAASIgGMGTLIGTPPNLiaaglleEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLP 147
|
|
| YbiR_permease |
cd01117 |
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ... |
260-443 |
6.10e-09 |
|
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.
Pssm-ID: 238537 [Multi-domain] Cd Length: 384 Bit Score: 57.67 E-value: 6.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 260 LCGFRPFSAYLNIANVALIGATILFMTKTISFEKTLHELNWGVLLTVGAITTLGTGLEKTGAGELIASSILDFFGGENAS 339
Cdd:cd01117 1 LALGRVPGLRLDRWAIALLGAALMLLFGVISLEDAPAAIDLDTIILLFGLMVVSAALELSGFFDALGSRILVKAGSPRRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 340 LTVVICVMFVLGSFLTlfmqNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASNM-AIATPIGTPVNMQI-LPAGYKFS 417
Cdd:cd01117 81 LFLLVLLSGILSALLT----NDTACLVFTPIVLELARVAGLPPIPLLLALATAANIgSAATPIGNPQNLLIaSESGISFP 156
|
170 180
....*....|....*....|....*.
gi 512628489 418 DYVKIGGPLwLLFMIVVCLTAPSLLF 443
Cdd:cd01117 157 FFLAAMAPL-ALLGLLLLLILLLVLF 181
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
275-436 |
1.86e-07 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 53.02 E-value: 1.86e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 275 VALIGATILFMTKTISFEKTLH----ELNWGVLLTVGAITTLGTGLEKTGAGELIASSILDFFGGENASLTVVICVmfvL 350
Cdd:cd01116 18 AALAGALWLVILGLATLSPDLEtivsWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGL---L 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 351 GSFLTLFMQNVSVSAMLAPIYIPLALKMGLSPVPFIILIAVASN-MAIATPIGTPVNMQI-LPAGYKFSDYVKIGGPLWL 428
Cdd:cd01116 95 TAFLSAFLDNVTTVLLMVPVTIRLCEVLGLNPVPVLISEVIAANiGGAATLIGDPPNIMIgSAAGLTFNDFLLHMLPSVV 174
|
....*...
gi 512628489 429 LFMIVVCL 436
Cdd:cd01116 175 LALVVTFI 182
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
8-205 |
3.26e-07 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 52.08 E-value: 3.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 8 IVIVAVTMVLFITRAF---PMAVTAVLCSLAMgIMLPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMGVAIG 84
Cdd:COG0471 178 LAIFALTVLLWITGSLhgiPIAVVALLGAVLL-LLTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 85 KLRIVQNERIFTVVVVTICTFMSAFMSDSGCIAMWMPIIAAVAAGSrgKIRSKMVIMPAGIACivGGATTLVGSTSQNTa 164
Cdd:COG0471 257 PLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL--GVNPLPLALAVAFAA--SCAFLLPVGTPPNA- 331
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 512628489 165 nsFLMQTAGYEMGmgvfDVTRIMWIVDIVMVLYFATIGYTI 205
Cdd:COG0471 332 --IVYGSGYYKFK----DFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| ArsB_permease |
cd01118 |
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ... |
250-414 |
9.23e-05 |
|
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.
Pssm-ID: 238538 [Multi-domain] Cd Length: 416 Bit Score: 44.56 E-value: 9.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 250 TLGICIVGFILCGFRPFSayLNIANVALIGATILFMTKTISFEKTLHELN--WGVLLTVGAITTLGTGLEKTGAGELIAS 327
Cdd:cd01118 2 AIAIFVLTLVLVIWRPFG--LPEAVWAVLGAVIALILGLVSPHDALEVWGivWDVTLTLIGVILLSLLLDEEGFFEWVAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 328 SILDFFGGENASLTVVIcvmFVLGSFLTLFMQNVSVSAMLAPIYIPLALKMGLSP---VPFIILIAVASNMA-IATPIGT 403
Cdd:cd01118 80 LAARWARGSGRKLFTLI---VLLGAAVTAFFANDGTALILTPIVIALLRALGAKKnrtLPFLYACAFIADAAsLPLPISN 156
|
170
....*....|.
gi 512628489 404 PVNmqILPAGY 414
Cdd:cd01118 157 LVN--IVTAGY 165
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
1-147 |
1.12e-04 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 44.11 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 1 MSETTLCIVIVAVTMVLFITRAFPMAVTAVLCSLAMgIMLPSVKLSAIYSGFGSAPVCMIAGMMIVGDAIFQTGVAQKMG 80
Cdd:cd01115 189 FRLAVLIITIVLLAALAAITGLLPVSVAIAIGAIVL-VFGGVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIA 267
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 512628489 81 VAIGKLRIVQNERIFTVVVVTICTFMSAFMSDSGCIAMWMPIIAAVAAGSrgKIRSKMVIMPAGIAC 147
Cdd:cd01115 268 EALISLLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLAPIALSIALSL--GLPPEALLLAVAIGA 332
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| GntT |
COG2610 |
H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and ... |
299-404 |
1.14e-03 |
|
H+/gluconate symporter GntT or related permease, GntP/DsdX family [Carbohydrate transport and metabolism];
Pssm-ID: 442022 [Multi-domain] Cd Length: 440 Bit Score: 41.25 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512628489 299 NWGVLLTVGAIttLGTGLEKTGAGELIASSILDFFGGENASLTVVIcVMFVLGsfLTLFMQNVSVsaMLAPIYIPLALKM 378
Cdd:COG2610 61 SIGLVIGLGAM--LGKLLEDSGAAERIADTIIKKFGEKRAPLALVL-AGFILG--IPVFFDVGFV--ILAPLAFSLARRA 133
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90 100
....*....|....*....|....*.
gi 512628489 379 GLSPVPFIILIAVASNMAIATPIGTP 404
Cdd:COG2610 134 GISKLLIGLALAAGLSTTHMLVPPTP 159
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