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Conserved domains on  [gi|512729117|ref|WP_016487046|]
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MULTISPECIES: GntR family transcriptional regulator [Pseudomonadota]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
19-193 7.91e-42

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 141.21  E-value: 7.91e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  19 IYELLREALITGRFQPDDRLRIRDLAEQLGTSVTPVRDAILQLAKEQALILKTPRDIRVPILTAAQYGEIRSIRLALEGL 98
Cdd:COG1802   16 VYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAALEGL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  99 AAETAAALVTDSELADLQACIENNIAAINAQDLQAALKCNQQFHYALTTIARMPVLAGLLDSLWMRTGPLIARAYGNFNE 178
Cdd:COG1802   96 AARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLSLRSPGR 175

                        170
                 ....*....|....*.
gi 512729117 179 -RMAIDHHWEVLDALK 193
Cdd:COG1802  176 lEESLAEHRAILDALE 191
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
19-193 7.91e-42

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 141.21  E-value: 7.91e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  19 IYELLREALITGRFQPDDRLRIRDLAEQLGTSVTPVRDAILQLAKEQALILKTPRDIRVPILTAAQYGEIRSIRLALEGL 98
Cdd:COG1802   16 VYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAALEGL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  99 AAETAAALVTDSELADLQACIENNIAAINAQDLQAALKCNQQFHYALTTIARMPVLAGLLDSLWMRTGPLIARAYGNFNE 178
Cdd:COG1802   96 AARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLSLRSPGR 175

                        170
                 ....*....|....*.
gi 512729117 179 -RMAIDHHWEVLDALK 193
Cdd:COG1802  176 lEESLAEHRAILDALE 191
PRK11414 PRK11414
GntR family transcriptional regulator;
12-193 4.97e-28

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 105.72  E-value: 4.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  12 HSYLGSGIYELLREALITGRFQPDDRLRIRDLAEQLGTSVTPVRDAILQLAKEQALILKTPRDIRVPILTAAQYGEIRSI 91
Cdd:PRK11414   9 HISLTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  92 RLALEGLAAETAAALVTDSELADLQACIENNIAAINAQDLQAALKCNQQFHYALTTIARMPVLAGLLDSLWMRTGPLIAR 171
Cdd:PRK11414  89 RYELELMAVALAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPILCEMIEQLWVRMGPSLHY 168

                        170       180
                 ....*....|....*....|....*
gi 512729117 172 AYGNFNE---RMAIDHHWEVLDALK 193
Cdd:PRK11414 169 LYEAINPaelREHIENYRLLLAALK 193
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 87-193 2.00e-15

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 69.71  E-value: 2.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117   87 EIRSIRLALEGLAAETAAALVTDSELADLQACIENNIAAINAQDLQAALKCNQQFHYALTTIARMPVLAGLLDSLWMRTG 166
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100
                  ....*....|....*....|....*...
gi 512729117  167 PLIARAYGNFNE-RMAIDHHWEVLDALK 193
Cdd:pfam07729  81 RLRRLLLSSPGRlRASLEEHRAILDAIR 108
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 87-193 3.29e-14

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 66.61  E-value: 3.29e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117    87 EIRSIRLALEGLAAETAAALVTDSELADLQACIENNIAAINAQD-LQAALKCNQQFHYALTTIARMPVLAGLLDSLWMRT 165
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDdLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100
                   ....*....|....*....|....*...
gi 512729117   166 GPLIARAYGNFneRMAIDHHWEVLDALK 193
Cdd:smart00895  81 RRLRRLSLEAA--RRALDEHRAILDAIR 106
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-64 4.47e-11

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 56.69  E-value: 4.47e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 512729117  19 IYELLREALITGRFQPDDRLR-IRDLAEQLGTSVTPVRDAILQLAKE 64
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAE 52
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
19-193 7.91e-42

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 141.21  E-value: 7.91e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  19 IYELLREALITGRFQPDDRLRIRDLAEQLGTSVTPVRDAILQLAKEQALILKTPRDIRVPILTAAQYGEIRSIRLALEGL 98
Cdd:COG1802   16 VYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEIRELYEVRAALEGL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  99 AAETAAALVTDSELADLQACIENNIAAINAQDLQAALKCNQQFHYALTTIARMPVLAGLLDSLWMRTGPLIARAYGNFNE 178
Cdd:COG1802   96 AARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARLRRYRRLSLRSPGR 175

                        170
                 ....*....|....*.
gi 512729117 179 -RMAIDHHWEVLDALK 193
Cdd:COG1802  176 lEESLAEHRAILDALE 191
PRK11414 PRK11414
GntR family transcriptional regulator;
12-193 4.97e-28

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 105.72  E-value: 4.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  12 HSYLGSGIYELLREALITGRFQPDDRLRIRDLAEQLGTSVTPVRDAILQLAKEQALILKTPRDIRVPILTAAQYGEIRSI 91
Cdd:PRK11414   9 HISLTLQVENDLKHQLSIGALKPGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  92 RLALEGLAAETAAALVTDSELADLQACIENNIAAINAQDLQAALKCNQQFHYALTTIARMPVLAGLLDSLWMRTGPLIAR 171
Cdd:PRK11414  89 RYELELMAVALAVENLTPQDLAELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPILCEMIEQLWVRMGPSLHY 168

                        170       180
                 ....*....|....*....|....*
gi 512729117 172 AYGNFNE---RMAIDHHWEVLDALK 193
Cdd:PRK11414 169 LYEAINPaelREHIENYRLLLAALK 193
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
19-193 2.53e-17

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 77.67  E-value: 2.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  19 IYELLREALITGRFQPDDRLRI-RDLAEQLGTSVTPVRDAILQLAKEQALILKTPRDIRV---------------PILTA 82
Cdd:COG2186   12 VAEQLRELILSGELKPGDRLPSeRELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVrepspwalldplallLALDD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  83 AQYGEIRSIRLALEGLAAETAAALVTDSELADLQACIENNIAAINaqDLQAALKCNQQFHYALTTIARMPVLAGLLDSLW 162
Cdd:COG2186   92 ASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEAAAD--DGEAFAEADLAFHRAIAEASGNPLLALLLESLR 169

                        170       180       190
                 ....*....|....*....|....*....|..
gi 512729117 163 MRTGPLIARAYGNFNERM-AIDHHWEVLDALK 193
Cdd:COG2186  170 ELLRRSVRLTLRSPEARErSLAEHRAILDAIR 201
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 87-193 2.00e-15

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 69.71  E-value: 2.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117   87 EIRSIRLALEGLAAETAAALVTDSELADLQACIENNIAAINAQDLQAALKCNQQFHYALTTIARMPVLAGLLDSLWMRTG 166
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100
                  ....*....|....*....|....*...
gi 512729117  167 PLIARAYGNFNE-RMAIDHHWEVLDALK 193
Cdd:pfam07729  81 RLRRLLLSSPGRlRASLEEHRAILDAIR 108
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 87-193 3.29e-14

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 66.61  E-value: 3.29e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117    87 EIRSIRLALEGLAAETAAALVTDSELADLQACIENNIAAINAQD-LQAALKCNQQFHYALTTIARMPVLAGLLDSLWMRT 165
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGDdLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100
                   ....*....|....*....|....*...
gi 512729117   166 GPLIARAYGNFneRMAIDHHWEVLDALK 193
Cdd:smart00895  81 RRLRRLSLEAA--RRALDEHRAILDAIR 106
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-64 4.47e-11

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 56.69  E-value: 4.47e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 512729117  19 IYELLREALITGRFQPDDRLR-IRDLAEQLGTSVTPVRDAILQLAKE 64
Cdd:cd07377    6 IADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAE 52
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 15-77 1.86e-10

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 54.93  E-value: 1.86e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 512729117   15 LGSGIYELLREALITGRFQPDDRL-RIRDLAEQLGTSVTPVRDAILQLAKEQALILKTPRDIRV 77
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
19-77 1.41e-09

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 52.58  E-value: 1.41e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117    19 IYELLREALITGRFQPDDRLR-IRDLAEQLGTSVTPVRDAILQLAKEQALILKTPRDIRV 77
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 20-117 6.93e-07

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 48.35  E-value: 6.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  20 YELLREALITGRFQPDDRLRIRDLAEQLGTSVTPVRDAILQLAKEQALILKTPRDIRVPILTAAQYGEIRSIRLALEGLA 99
Cdd:PRK11534  13 YRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFDARANMEAML 92

                         90
                 ....*....|....*...
gi 512729117 100 AETAAALVTDSELADLQA 117
Cdd:PRK11534  93 VSLAIARGGDEWEADVLA 110
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
19-64 3.68e-06

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 46.39  E-value: 3.68e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 512729117  19 IYELLREALITGRFQPDDRL-RIRDLAEQLGTSVTPVRDAILQLAKE 64
Cdd:COG2188   10 IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEE 56
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 25-193 3.72e-06

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 46.17  E-value: 3.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  25 EALIT-GRFQPDDRL-RIRDLAEQLGTSVTPVRDAILQLAK---------EQALILK-TPRDI------RVPILTAAQYG 86
Cdd:PRK03837  23 EQMIRsGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRkglvqishgERARVSRpSADTIigqlsgMAKDFLSQSPD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  87 EI---RSIRLALEGLAAETAAALVTDSELADLQACIENNIAAINaqDLQAALKCNQQFHYALTTIARMPVLAGLLDSL-- 161
Cdd:PRK03837 103 GLahlKQARLFFESSLARYAAEHATDEQIALLRKALERNSQSLG--DNAAFIRSDMEFHRVIAEIPGNPIFMAIHEALld 180

                        170       180       190
                 ....*....|....*....|....*....|...
gi 512729117 162 WMRTG-PLIARAYGNfnERMAIDHHWEVLDALK 193
Cdd:PRK03837 181 WLIEArPEVVILHGH--ENVTLQEHIAIVDAIR 211
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 19-64 1.12e-04

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 42.51  E-value: 1.12e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 512729117  19 IYELLREALITGRFQPDDRL-RIRDLAEQLGTSVTPVRDAILQLAKE 64
Cdd:COG1167   17 LADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAE 63
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
19-171 3.98e-04

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 40.39  E-value: 3.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  19 IYELLREALITGRFQPDDRLRI-RDLAEQLGTSVTPVRDAILQL-AKE------------QALILKTPRDIRVPILTA-- 82
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPeRELAKQFDVSRPSLREAIQRLeAKGlllrrqgggtfvQSSLWQSFSDPLVELLSDhp 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  83 -AQYGEIRSiRLALEGLAAETAAALVTDSELADLQACIENNIAAINAQDLQAALKCNQQFHYALTTIARMPVLAGLLDSL 161
Cdd:PRK09464  95 eSQFDLLET-RHALEGIAAYYAALRGTDEDFERIRECHHAIELAQQSGDLDAEANAVMQYQIAVTEAAHNVVLLHLLRCM 173

                        170
                 ....*....|
gi 512729117 162 wmrtGPLIAR 171
Cdd:PRK09464 174 ----EPMLEQ 179
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 26-208 1.06e-03

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 38.98  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  26 ALITGR-FQPDDRLRI-RDLAEQLGTSVTPVRDAILQLAKEQALILK--------------TPRDIRVPILTA----AQY 85
Cdd:PRK10421  13 ALIEEKnLEAGMKLPAeRQLAMQLGVSRNSLREALAKLVSEGVLLSRrgggtfirwrhetwSEQNIVQPLKTLmaddPDY 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 512729117  86 G-EIRSIRLALEGLAAETAAALVTDSELADLQACIEnniaAINAQDLQAALKCNQQFHYA-------LTTIARMPVLAGL 157
Cdd:PRK10421  93 SfDILEARHAIEASTAWHAAMRATPGDKEKIQLCFE----ATLSEDPDLASQADVRFHLAiaeashnVVLLQTMRGFFDV 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 512729117 158 LDSLWMRTGPLIARAYGNFNERMAidHHWEVLDALKRRDGAAARAAICRDI 208
Cdd:PRK10421 169 LQSSVKQSRQRMYLVPPVFSQLTE--QHQAVMDAILAGDAEGARKAMMAHL 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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