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Conserved domains on  [gi|514902318|ref|WP_016628061|]
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glycosyltransferase family 4 protein [Enterococcus faecium]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133453)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 38-340 1.66e-32

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 124.57  E-value: 1.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  38 RALTEVGISYTLdekEDYDILHINTYGInSHNMVNKARREGKKVVYHAHSTEEDFRNSFigSNQLSPIVKKYLVgLYQKA 117
Cdd:cd03801   69 RLLRELRPLLRL---RKFDVVHAHGLLA-ALLAALLALLLGAPLVVTLHGAEPGRLLLL--LAAERRLLARAEA-LLRRA 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 118 DYLITPTPYSKQLLESYGIRVP--IQAISNGIDLEKYRPDPMKEqkfreyFKLSPDQKVIICVGLFFERKGIIDFVEIAK 195
Cdd:cd03801  142 DAVIAVSEALRDELRALGGIPPekIVVIPNGVDLERFSPPLRRK------LGIPPDRPVLLFVGRLSPRKGVDLLLEALA 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 196 KM----PEYTFIWFGHVPmySIPRNIRKIVKEDHpENVLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALASKQ 271
Cdd:cd03801  216 KLlrrgPDVRLVIVGGDG--PLRAELEELELGLG-DRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGL 292

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514902318 272 NVLVRDIPVYNGWLEDSKNCYM--GKTNEEFIR-LIQQITNQELPSTT-QAGYQTAKER-SINKIGEELKNVYE 340
Cdd:cd03801  293 PVVATDVGGLPEVVEDGEGGLVvpPDDVEALADaLLRLLADPELRARLgRAARERVAERfSWERVAERLLDLYR 366
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 38-340 1.66e-32

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 124.57  E-value: 1.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  38 RALTEVGISYTLdekEDYDILHINTYGInSHNMVNKARREGKKVVYHAHSTEEDFRNSFigSNQLSPIVKKYLVgLYQKA 117
Cdd:cd03801   69 RLLRELRPLLRL---RKFDVVHAHGLLA-ALLAALLALLLGAPLVVTLHGAEPGRLLLL--LAAERRLLARAEA-LLRRA 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 118 DYLITPTPYSKQLLESYGIRVP--IQAISNGIDLEKYRPDPMKEqkfreyFKLSPDQKVIICVGLFFERKGIIDFVEIAK 195
Cdd:cd03801  142 DAVIAVSEALRDELRALGGIPPekIVVIPNGVDLERFSPPLRRK------LGIPPDRPVLLFVGRLSPRKGVDLLLEALA 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 196 KM----PEYTFIWFGHVPmySIPRNIRKIVKEDHpENVLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALASKQ 271
Cdd:cd03801  216 KLlrrgPDVRLVIVGGDG--PLRAELEELELGLG-DRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGL 292

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514902318 272 NVLVRDIPVYNGWLEDSKNCYM--GKTNEEFIR-LIQQITNQELPSTT-QAGYQTAKER-SINKIGEELKNVYE 340
Cdd:cd03801  293 PVVATDVGGLPEVVEDGEGGLVvpPDDVEALADaLLRLLADPELRARLgRAARERVAERfSWERVAERLLDLYR 366
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
51-150 9.10e-15

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 71.41  E-value: 9.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318   51 EKEDYDILHINTYGINSHNMVNKARREGKKVVYHAHSTEEDFRNSFIGSNQLSPIVKKYLVGLYQKADYLITPTPYSKQ- 129
Cdd:pfam13439  68 RRERPDVVHAHSPFPLGLAALAARLRLGIPLVVTYHGLFPDYKRLGARLSPLRRLLRRLERRLLRRADRVIAVSEAVADe 147

                          90       100
                  ....*....|....*....|..
gi 514902318  130 LLESYGI-RVPIQAISNGIDLE 150
Cdd:pfam13439 148 LRRLYGVpPEKIRVIPNGVDLE 169
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 56-269 2.82e-12

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 67.43  E-value: 2.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  56 DILHINTYGInshnMVNKARREGKKV------VYHAHSTeedfrnSFIGSNQLSPIVK---KYLVGLYQKADYLITPTPY 126
Cdd:PLN02871 146 DLIHASSPGI----MVFGALFYAKLLcvplvmSYHTHVP------VYIPRYTFSWLVKpmwDIIRFLHRAADLTLVTSPA 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 127 SKQLLESYGIRVP--IQAISNGIDLE----KYRPDPMKEqkfreyfKLS---PDQKVIICVGLFFERKGIIDFVEIAKKM 197
Cdd:PLN02871 216 LGKELEAAGVTAAnrIRVWNKGVDSEsfhpRFRSEEMRA-------RLSggePEKPLIVYVGRLGAEKNLDFLKRVMERL 288

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514902318 198 PEYTFIWFGHVPmysiprniRKIVKEDHPE--NVLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALAS 269
Cdd:PLN02871 289 PGARLAFVGDGP--------YREELEKMFAgtPTVFTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMAS 354
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 238-344 8.18e-12

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 61.54  E-value: 8.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 238 EIIEGAYSGADLFFFPSYEETEGIVVLEALASKQNVLVRDIPVYNGWLEDSKNCYMGKTN--EEFIRLIQQITN--QELP 313
Cdd:COG0438   12 LLLEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGdpEALAEAILRLLEdpELRR 91

                         90       100       110
                 ....*....|....*....|....*....|..
gi 514902318 314 STTQAGYQTAKER-SINKIGEELKNVYESVLN 344
Cdd:COG0438   92 RLGEAARERAEERfSWEAIAERLLALYEELLA 123
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 38-340 1.66e-32

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 124.57  E-value: 1.66e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  38 RALTEVGISYTLdekEDYDILHINTYGInSHNMVNKARREGKKVVYHAHSTEEDFRNSFigSNQLSPIVKKYLVgLYQKA 117
Cdd:cd03801   69 RLLRELRPLLRL---RKFDVVHAHGLLA-ALLAALLALLLGAPLVVTLHGAEPGRLLLL--LAAERRLLARAEA-LLRRA 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 118 DYLITPTPYSKQLLESYGIRVP--IQAISNGIDLEKYRPDPMKEqkfreyFKLSPDQKVIICVGLFFERKGIIDFVEIAK 195
Cdd:cd03801  142 DAVIAVSEALRDELRALGGIPPekIVVIPNGVDLERFSPPLRRK------LGIPPDRPVLLFVGRLSPRKGVDLLLEALA 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 196 KM----PEYTFIWFGHVPmySIPRNIRKIVKEDHpENVLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALASKQ 271
Cdd:cd03801  216 KLlrrgPDVRLVIVGGDG--PLRAELEELELGLG-DRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGLVVLEAMAAGL 292

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514902318 272 NVLVRDIPVYNGWLEDSKNCYM--GKTNEEFIR-LIQQITNQELPSTT-QAGYQTAKER-SINKIGEELKNVYE 340
Cdd:cd03801  293 PVVATDVGGLPEVVEDGEGGLVvpPDDVEALADaLLRLLADPELRARLgRAARERVAERfSWERVAERLLDLYR 366
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 74-342 1.61e-29

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 116.61  E-value: 1.61e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  74 ARREGKKVVYHAHSTEEDFRNSFIGSNQLSPIVKKYLVG-LYQKADYLITPTPYSKQLLESYGIRVPIQAISNGIDLEKY 152
Cdd:cd03817  104 ARKLKIPIVHTYHTMYEDYLHYIPKGKLLVKAVVRKLVRrFYNHTDAVIAPSEKIKDTLREYGVKGPIEVIPNGIDLDKF 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 153 RPDPMKEqkFREYFKLSPDQKVIICVGLFFERKGI---IDFVEIAKKMPEYTFIWFGHVPmYSipRNIRKIVKEDH-PEN 228
Cdd:cd03817  184 EKPLNTE--ERRKLGLPPDEPILLYVGRLAKEKNIdflLRAFAELKKEPNIKLVIVGDGP-ER--EELKELARELGlADK 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 229 VLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALASKQNVLVRDIPVYNGWLEDSKNCYMGKTNEEFI-----RL 303
Cdd:cd03817  259 VIFTGFVPREELPEYYKAADLFVFASTTETQGLVYLEAMAAGLPVVAAKDPAASELVEDGENGFLFEPNDETLaekllHL 338

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 514902318 304 IQQITNQELPSttQAGYQTAKERSINKigeELKNVYESV 342
Cdd:cd03817  339 RENLELLRKLS--KNAEISAREFAFAK---SVEKLYEEV 372
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 3-283 5.92e-19

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 86.64  E-value: 5.92e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318   3 YYISEGGRKVKVLLYFESEKMLAKSGIGRALDHQKRaltevgiSYTLDEKEDYDILHINTYGINSHNMVnKARREGKKVV 82
Cdd:cd03819   32 LVVTAGGPLLPRLRQIGIGLPGLKVPLLRALLGNVR-------LARLIRRERIDLIHAHSRAPAWLGWL-ASRLTGVPLV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  83 YHAHsteedfrnsfiGSNQLSPIVKKYLVGLYQKADYLITPTPYSKQ-LLESYGI-RVPIQAISNGIDLEKYRPDPmkEQ 160
Cdd:cd03819  104 TTVH-----------GSYLATYHPKDFALAVRARGDRVIAVSELVRDhLIEALGVdPERIRVIPNGVDTDRFPPEA--EA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 161 KFREYFKLSPDQKVIICVGLFFERKGIIDFVEIA---KKMPEYTFIWFGHVP-MYSIPRNIRKIVKEDHpenVLFPGYIr 236
Cdd:cd03819  171 EERAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAaelKDEPDFRLLVAGDGPeRDEIRRLVERLGLRDR---VTFTGFR- 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 514902318 237 gEIIEGAYSGADLFFFPSYEETEGIVVLEALASKQNVLVRDIPVYNG 283
Cdd:cd03819  247 -EDVPAALAASDVVVLPSLHEEFGRVALEAMACGTPVVATDVGGARE 292
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 74-342 1.33e-18

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 85.89  E-value: 1.33e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  74 ARREGKKVVYHAHSteedfrnSFIGSNQLSPIVKKYLVGLYQKADYLITPTPYSKQLLESYG-IRVPIQAISNGIDLEKY 152
Cdd:cd03798  115 ARLYGVPYVVTEHG-------SDINVFPPRSLLRKLLRWALRRAARVIAVSKALAEELVALGvPRDRVDVIPNGVDPARF 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 153 RPDPmkeqkfrEYFKLSPDQKVIICVGLFFERKGIIDFVE----IAKKMPEYTFIWFGHVPMysiPRNIRKIVKEDHPEN 228
Cdd:cd03798  188 QPED-------RGLGLPLDAFVILFVGRLIPRKGIDLLLEafarLAKARPDVVLLIVGDGPL---REALRALAEDLGLGD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 229 -VLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALASKQNVL------VRDI--PVYNGWLEDSKNcyMGKTNEE 299
Cdd:cd03798  258 rVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVatdvggIPEVvgDPETGLLVPPGD--ADALAAA 335

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 514902318 300 FIRLIQQITNQELPsttQAGYQT-AKERSINKIGEELKNVYESV 342
Cdd:cd03798  336 LRRALAEPYLRELG---EAARARvAERFSWVKAADRIAAAYRDV 376
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 49-269 7.26e-18

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 83.50  E-value: 7.26e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  49 LDEKEDYDILHINTYGINSHNMVNKARREGKKVV--YHAHSTE--EDFRNSFigsnqLSPIVKKYLVGLYQKADYLITPT 124
Cdd:cd03814   79 LIKEFQPDIIHIATPGPLGLAALRAARRLGLPVVtsYHTDFPEylSYYTLGP-----LSWLAWAYLRWFHNPFDTTLVPS 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 125 PYSKQLLESYGIRvPIQAISNGIDLEKYRPDpMKEQKFREYFkLSPDQKVIICVGLFFERKGIIDFVEIAKKMPE---YT 201
Cdd:cd03814  154 PSIARELEGHGFE-RVRLWPRGVDTELFHPS-RRDAALRRRL-GPPGRPLLLYVGRLAPEKNLEALLDADLPLAAsppVR 230

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 514902318 202 FIWFGHVPmysiprnIRKIVKEDHPeNVLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALAS 269
Cdd:cd03814  231 LVVVGDGP-------ARAELEARGP-DVIFTGFLTGEELARAYASADVFVFPSRTETFGLVVLEAMAS 290
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 51-308 3.60e-17

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 81.65  E-value: 3.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  51 EKEDYDILHIN-TYGINSHNMVNKARREGKKVVYHAHSTEEDFrnsfigSNQLSPIVKKYLVGLYQK-----ADYLITPT 124
Cdd:cd03821   87 NLREYDVVHIHgVWTYTSLAACKLARRRGIPYVVSPHGMLDPW------ALQQKHWKKRIALHLIERrnlnnAALVHFTS 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 125 PYSKQLLESYGIRVPIQAISNGIDLEKYRPDPMKEQKFReyfkLSPDQKVIICVGLFFERKGIIDFVEIAKKMPEYTFIW 204
Cdd:cd03821  161 EQEADELRRFGLEPPIAVIPNGVDIPEFDPGLRDRRKHN----GLEDRRIILFLGRIHPKKGLDLLIRAARKLAEQGRDW 236

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 205 FGHVPMY---SIPRNIRKIVKEDHPENVLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALASKQNVLVRDIPvy 281
Cdd:cd03821  237 HLVIAGPddgAYPAFLQLQSSLGLGDRVTFTGPLYGEAKWALYASADLFVLPSYSENFGNVVAEALACGLPVVITDKC-- 314

                        250       260
                 ....*....|....*....|....*....
gi 514902318 282 NGWLEDSKNC-YMGKTNEEFIR-LIQQIT 308
Cdd:cd03821  315 GLSELVEAGCgVVVDPNVSSLAeALAEAL 343
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 116-280 6.35e-16

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 77.79  E-value: 6.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 116 KADYLITPTPYSK-QLLESYGIRV-PIQAISNGIDLEkYRPDPmKEQKFREYFKLspDQKVIICVGLFFERKGIIDFVEI 193
Cdd:cd03809  138 RADAIITVSEATRdDIIKFYGVPPeKIVVIPLGVDPS-FFPPE-SAAVLIAKYLL--PEPYFLYVGTLEPRKNHERLLKA 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 194 AKKMPEYTFIWF----GhvPMYSIPRNIRKIVKE-DHPENVLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALA 268
Cdd:cd03809  214 FALLKKQGGDLKlvivG--GKGWEDEELLDLVKKlGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMA 291

                        170
                 ....*....|..
gi 514902318 269 SKQNVLVRDIPV 280
Cdd:cd03809  292 CGTPVIASNISV 303
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 52-279 5.91e-15

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 75.05  E-value: 5.91e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  52 KEDYDILHINTYGINSHNMVNKARREGKKVVYHAHSTEEDFRnsfigsnqLSPIVKKYLVGLYQKADYLITPTPYSKQLL 131
Cdd:cd03807   77 KRNPDVVHTWMYHADLIGGLAAKLAGGVKVIWSVRSSNIPQR--------LTRLVRKLCLLLSKFSPATVANSSAVAEFH 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 132 ESYGIR-VPIQAISNGIDLEKYRPDPMKEQKFREYFKLSPDQKVIICVGLFFERKGIIDFVE----IAKKMPEYTFIWFG 206
Cdd:cd03807  149 QEQGYAkNKIVVIYNGIDLFKLSPDDASRARARRRLGLAEDRRVIGIVGRLHPVKDHSDLLRaaalLVETHPDLRLLLVG 228

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514902318 207 HVPMYsipRNIRKIVKEDHPEN-VLFPGYiRGEIIEgAYSGADLFFFPSYEETEGIVVLEALASKQNVLVRDIP 279
Cdd:cd03807  229 RGPER---PNLERLLLELGLEDrVHLLGE-RSDVPA-LLPAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVG 297
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
51-150 9.10e-15

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 71.41  E-value: 9.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318   51 EKEDYDILHINTYGINSHNMVNKARREGKKVVYHAHSTEEDFRNSFIGSNQLSPIVKKYLVGLYQKADYLITPTPYSKQ- 129
Cdd:pfam13439  68 RRERPDVVHAHSPFPLGLAALAARLRLGIPLVVTYHGLFPDYKRLGARLSPLRRLLRRLERRLLRRADRVIAVSEAVADe 147

                          90       100
                  ....*....|....*....|..
gi 514902318  130 LLESYGI-RVPIQAISNGIDLE 150
Cdd:pfam13439 148 LRRLYGVpPEKIRVIPNGVDLE 169
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 52-293 4.77e-14

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 72.39  E-value: 4.77e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  52 KEDYDILHINTYGINshNMVNKARREGKKVVYHAHsteedfrNSFIGSNQLSPIVKKYLVgLYQKADYLITPTPYSKQLL 131
Cdd:cd03811   81 RAKPDVVISFLGFAT--YIVAKLAAARSKVIAWIH-------SSLSKLYYLKKKLLLKLK-LYKKADKIVCVSKGIKEDL 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 132 ESYGIRVP--IQAISNGIDLEKYRPDPmKEQKFREyfklSPDQKVIICVGLFFERKG---IID-FVEIAKKMPEYTFIWF 205
Cdd:cd03811  151 IRLGPSPPekIEVIYNPIDIDRIRALA-KEPILNE----PEDGPVILAVGRLDPQKGhdlLIEaFAKLRKKYPDVKLVIL 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 206 GHVPMYsiPRNIRKIVKEDHPENVLFPGYIRGeiIEGAYSGADLFFFPSYEETEGIVVLEALASKQNVLVRDIPVYNGWL 285
Cdd:cd03811  226 GDGPLR--EELEKLAKELGLAERVIFLGFQSN--PYPYLKKADLFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREIL 301


                 ....*...
gi 514902318 286 EDSKNCYM 293
Cdd:cd03811  302 DDGENGLL 309
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 171-313 1.20e-13

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 67.68  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  171 DQKVIICVGLFFERKGIIDFVE----IAKKMPEYTFIWFGHVPMYSipRNIRKIVKEDHPENVLFPGYI-RGEIIEgAYS 245
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKafalLKEKNPNLKLVIAGDGEEEK--RLKKLAEKLGLGDNVIFLGFVsDEDLPE-LLK 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 514902318  246 GADLFFFPSYEETEGIVVLEALASKQNVLVRDIPVY--------NGWLEDSKNcymgktNEEFIRLIQQI-TNQELP 313
Cdd:pfam00534  78 IADVFVLPSRYEGFGIVLLEAMACGLPVIASDVGGPpevvkdgeTGFLVKPNN------AEALAEAIDKLlEDEELR 148
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 52-279 2.07e-13

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 70.32  E-value: 2.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  52 KEDYDILHINT-----YGInshnMVNKARReGKKVVYHAHSTeedfrnSFIGSNQlsPIVKKYLVGLY----QKADYLIT 122
Cdd:cd03808   79 KEKPDIVHCHTpkpgiLGR----LAARLAG-VPKVIYTVHGL------GFVFTEG--KLLRLLYLLLEklalLFTDKVIF 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 123 PTPYSKQLLESYGIRVPIQAI---SNGIDLEKYRPDPMKeqkfreyfkLSPDQKVIICVGLFFERKGIIDFVEIAKKM-- 197
Cdd:cd03808  146 VNEDDRDLAIKKGIIKKKKTVlipGSGVDLDRFQYSPES---------LPSEKVVFLFVARLLKDKGIDELIEAAKILkk 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 198 --PEYTFIWFGHVPmySIPRNIRKIVKEDHPENVLFPGYIRGeiIEGAYSGADLFFFPSYEETEGIVVLEALASKQNVLV 275
Cdd:cd03808  217 kgPNVRFLLVGDGE--LENPSEILIEKLGLEGRIEFLGFRSD--VPELLAESDVFVLPSYREGLPRSLLEAMAAGRPVIT 292


                 ....
gi 514902318 276 RDIP 279
Cdd:cd03808  293 TDVP 296
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 113-278 1.03e-12

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 68.51  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 113 LYQKAD-YLITPTPYSKQLLESYGI--RVPIQAISNGIDLEKYRPDPMKeqKFREYFKLSPDQKVIICV--GLFFERKGI 187
Cdd:cd03825  133 ALAKKRlTIVAPSRWLADMVRRSPLlkGLPVVVIPNGIDTEIFAPVDKA--KARKRLGIPQDKKVILFGaeSVTKPRKGF 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 188 IDFVEIAKKM---PEYTFIWFGHVPMYS--IPRNIRKIvkedhpenvlfpGYIRGEI-IEGAYSGADLFFFPSYEETEGI 261
Cdd:cd03825  211 DELIEALKLLatkDDLLLVVFGKNDPQIviLPFDIISL------------GYIDDDEqLVDIYSAADLFVHPSLADNLPN 278

                        170
                 ....*....|....*..
gi 514902318 262 VVLEALASKQNVLVRDI 278
Cdd:cd03825  279 TLLEAMACGTPVVAFDT 295
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 56-269 2.82e-12

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 67.43  E-value: 2.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  56 DILHINTYGInshnMVNKARREGKKV------VYHAHSTeedfrnSFIGSNQLSPIVK---KYLVGLYQKADYLITPTPY 126
Cdd:PLN02871 146 DLIHASSPGI----MVFGALFYAKLLcvplvmSYHTHVP------VYIPRYTFSWLVKpmwDIIRFLHRAADLTLVTSPA 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 127 SKQLLESYGIRVP--IQAISNGIDLE----KYRPDPMKEqkfreyfKLS---PDQKVIICVGLFFERKGIIDFVEIAKKM 197
Cdd:PLN02871 216 LGKELEAAGVTAAnrIRVWNKGVDSEsfhpRFRSEEMRA-------RLSggePEKPLIVYVGRLGAEKNLDFLKRVMERL 288

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 514902318 198 PEYTFIWFGHVPmysiprniRKIVKEDHPE--NVLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVLEALAS 269
Cdd:PLN02871 289 PGARLAFVGDGP--------YREELEKMFAgtPTVFTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMAS 354
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
173-269 3.37e-12

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 63.30  E-value: 3.37e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  173 KVIICVG-LFFERKGIIDFVE----IAKKMPEYTFIWFGHVPMYSIPRNIRKIvkedhPENVLFPGYIRgEIIEgAYSGA 247
Cdd:pfam13692   2 PVILFVGrLHPNVKGVDYLLEavplLRKRDNDVRLVIVGDGPEEELEELAAGL-----EDRVIFTGFVE-DLAE-LLAAA 74

                          90       100
                  ....*....|....*....|..
gi 514902318  248 DLFFFPSYEETEGIVVLEALAS 269
Cdd:pfam13692  75 DVFVLPSLYEGFGLKLLEAMAA 96
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 238-344 8.18e-12

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 61.54  E-value: 8.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 238 EIIEGAYSGADLFFFPSYEETEGIVVLEALASKQNVLVRDIPVYNGWLEDSKNCYMGKTN--EEFIRLIQQITN--QELP 313
Cdd:COG0438   12 LLLEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGdpEALAEAILRLLEdpELRR 91

                         90       100       110
                 ....*....|....*....|....*....|..
gi 514902318 314 STTQAGYQTAKER-SINKIGEELKNVYESVLN 344
Cdd:COG0438   92 RLGEAARERAEERfSWEAIAERLLALYEELLA 123
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 143-277 2.44e-11

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 64.39  E-value: 2.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 143 ISNGIDLEKYRPDPMKEQKFREYFKLSPDQKVIICVGLFFERKG----IIDFVEIAKKMPEYTFIWFGHVPMYSiprNIR 218
Cdd:cd04951  159 VYNGIDLNKFKKDINVRLKIRNKLNLKNDEFVILNVGRLTEAKDypnlLLAISELILSKNDFKLLIAGDGPLRN---ELE 235

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 219 KIVKEDH-PENVLFPGYIRGeiIEGAYSGADLFFFPSYEETEGIVVLEALASKQNVLVRD 277
Cdd:cd04951  236 RLICNLNlVDRVILLGQISN--ISEYYNAADLFVLSSEWEGFGLVVAEAMACERPVVATD 293
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 47-279 9.00e-11

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 62.31  E-value: 9.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  47 YTLDEKEDYDILHINtygINSHNMVN--KARREGKKV-VYHAHSTE-EDFRNSFIGSNQLSPIVK----KYLVGLYQKAD 118
Cdd:cd03812   73 LKLIKKEKYDIVHVH---GSSSNGIIllLAAKAGVPVrIAHSHNTKdSSIKLRKIRKNVLKKLIErlstKYLACSEDAGE 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 119 YLITPTPYSKQLLesygirvpiqaISNGIDLEKYRPDPMKEQKFREYfKLSPDQKVIICVGLFFERKG---IID-FVEIA 194
Cdd:cd03812  150 WLFGEVENGKFKV-----------IPNGIDIEKYKFNKEKRRKRRKL-LILEDKLVLGHVGRFNEQKNhsfLIDiFEELK 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 195 KKMPEYTFIWFGHVP-MYSIprnIRKIVKEDHPENVLFPGYiRGEIIEgAYSGADLFFFPSYEETEGIVVLEALASKQNV 273
Cdd:cd03812  218 KKNPNVKLVLVGEGElKEKI---KEKVKELGLEDKVIFLGF-RNDVSE-ILSAMDVFLFPSLYEGLPLVAVEAQASGLPC 292


                 ....*.
gi 514902318 274 LVRDIP 279
Cdd:cd03812  293 LLSDTI 298
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 117-269 1.56e-10

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 61.87  E-value: 1.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 117 ADYLITPTPYSKQ-LLESYGI-RVPIQAISNGIDLEKYRPDPmKEQKFREYFKLSPDQKVIICVGLFFERKGIIDFVEIA 194
Cdd:cd03800  164 ADRVIASTPQEADeLISLYGAdPSRINVVPPGVDLERFFPVD-RAEARRARLLLPPDKPVVLALGRLDPRKGIDTLVRAF 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 195 KKMPEYTF-----IWFGhvPMYSI----PRNIRKIVKEDH-PENVLFPGYIRGEIIEGAYSGADLFFFPSYEETEGIVVL 264
Cdd:cd03800  243 AQLPELRElanlvLVGG--PSDDPlsmdREELAELAEELGlIDRVRFPGRVSRDDLPELYRAADVFVVPSLYEPFGLTAI 320


                 ....*
gi 514902318 265 EALAS 269
Cdd:cd03800  321 EAMAC 325
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 176-292 4.78e-10

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 59.34  E-value: 4.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 176 ICVGLFFERKGIIDFVEIAKKMPE----YTFIWFGHVPMYsiPRNIRKIVKEDHPENVLFPG-YIRGEIIEGAYSGADLF 250
Cdd:cd01635  114 VSVGRLVPEKGIDLLLEALALLKArlpdLVLVLVGGGGER--EEEEALAAALGLLERVVIIGgLVDDEVLELLLAAADVF 191

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 514902318 251 FFPSYEETEGIVVLEALASKQNVLVRDIPVYNGWLEDSKNCY 292
Cdd:cd01635  192 VLPSRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGL 233
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 49-253 1.79e-09

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 58.51  E-value: 1.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  49 LDEKEDYDILHINTYGINSHNMVNK-ARREGKKVVYHAHSTE-EDFRNSFIGSNQLSPIVKKYLVG-LYQKADYLITPTP 125
Cdd:cd03794   93 LVREERPDVIIAYSPPITLGLAALLlKKLRGAPFILDVRDLWpESLIALGVLKKGSLLKLLKKLERkLYRLADAIIVLSP 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 126 YSKQLLESYGIRV-PIQAISNGIDLEKYRPDPMKEQKFReyfKLSPDQKVIICVGLFFERKGIIDFVEIAKKMPEYT--- 201
Cdd:cd03794  173 GLKEYLLRKGVPKeKIIVIPNWADLEEFKPPPKDELRKK---LGLDDKFVVVYAGNIGKAQGLETLLEAAERLKRRPdir 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 514902318 202 FIWFGHVPMYSiprNIRKIVKEDHPENVLFPGYIRGEIIEGAYSGADLFFFP 253
Cdd:cd03794  250 FLFVGDGDEKE---RLKELAKARGLDNVTFLGRVPKEEVPELLSAADVGLVP 298
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 132-268 7.71e-08

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 53.51  E-value: 7.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 132 ESYGIRVPIQAISNGIDLEKYRPDPMKEQKFReyFKLSPDQKVIICVGLFFERKGIID----FVEIAKKMPEyTFIWFGH 207
Cdd:cd04962  158 ELFDVDKDIEVIHNFIDEDVFKRKPAGALKRR--LLAPPDEKVVIHVSNFRPVKRIDDvvrvFARVRRKIPA-KLLLVGD 234

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 514902318 208 VPMYSiprNIRKIVKEDHPEN-VLFPGyiRGEIIEGAYSGADLFFFPSYEETEGIVVLEALA 268
Cdd:cd04962  235 GPERV---PAEELARELGVEDrVLFLG--KQDDVEELLSIADLFLLPSEKESFGLAALEAMA 291
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 55-331 7.50e-07

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 50.38  E-value: 7.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  55 YDILHINTYGINSHNMVNKARREGKKVVYHA-HSTEEDfrnsfigSNQLSPIVKKYLVGLYQ--KADYLITPTPYSKQLL 131
Cdd:cd04949   56 GDIFISDRPTLTGQVILNTKGPAKKGAVLHNeHVKNND-------DPEHSLIKNFYKYVFENlnKYDAIIVSTEQQKQDL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 132 -ESYGIRVPIQAISNGIDLEKYRPDPMKEQKfreyfklspdQKVIICVGLFFERKGIIDFVEIA----KKMPEYTFIWFG 206
Cdd:cd04949  129 sERFNKYPPIFTIPVGYVDQLDTAESNHERK----------SNKIITISRLAPEKQLDHLIEAVakavKKVPEITLDIYG 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 207 HVpmySIPRNIRKIVKEDHPE-NVLFPGYIRGEIIEgaYSGADLFFFPSYEETEGIVVLEALASKQNVLVRDIPvY--NG 283
Cdd:cd04949  199 YG---EEREKLKKLIEELHLEdNVFLKGYHSNLDQE--YQDAYLSLLTSQMEGFGLTLMEAIGHGLPVVSYDVK-YgpSE 272

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 514902318 284 WLEDSKNCYM---GKTNEEFIRLIQQITNQELPST-TQAGYQTAKERSINKI 331
Cdd:cd04949  273 LIEDGENGYLiekNNIDALADKIIELLNDPEKLQQfSEESYKIAEKYSTENV 324
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 52-268 8.93e-07

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 50.35  E-value: 8.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  52 KEDYDILHI---NTYGINSHNMVNKArregKKVVYHAHSTeedfrnsfigsnqlspIVK-KYLVGLYQ--------KADY 119
Cdd:cd03795   81 AKEYDIIHYhfpNPLADLLLFFSGAK----KPVVVHWHSD----------------IVKqKKLLKLYKplmtrflrRADR 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 120 LITPTP-Y---SKQLLEsygIRVPIQAISNGIDLEKYRPDPMKEQKFREYFKlspDQKVIICVGLFFERKGIIDFVEIAK 195
Cdd:cd03795  141 IIATSPnYvetSPTLRE---FKNKVRVIPLGIDKNVYNIPRVDFENIKREKK---GKKIFLFIGRLVYYKGLDYLIEAAQ 214

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 514902318 196 KMPEYTFIwFGHVPMYSiprNIRKIVKEDHPENVLFPGYIRGEIIEGAYSGADLFFFPSYEETE--GIVVLEALA 268
Cdd:cd03795  215 YLNYPIVI-GGEGPLKP---DLEAQIELNLLDNVKFLGRVDDEEKVIYLHLCDVFVFPSVLRSEafGIVLLEAMM 285
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 56-285 9.63e-06

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 46.94  E-value: 9.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  56 DILHINTYGINSHNMVNKARREGKKVVYHAHsteeDFrnsfigsNQLSPIVKKYLVGlyqkADYLITPTPYSKQLLESYG 135
Cdd:cd03823   98 DVVHTHNLSGLGASLLDAARDLGIPVVHTLH----DY-------WLLCPRQFLFKKG----GDAVLAPSRFTANLHEANG 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 136 I-RVPIQAISNGIDLEKYRPdpmkEQKFReyfklSPDQKVIICVGLFFERKGIIDFVEIAKKMP--EYTFIWFGHVPMYS 212
Cdd:cd03823  163 LfSARISVIPNAVEPDLAPP----PRRRP-----GTERLRFGYIGRLTEEKGIDLLVEAFKRLPreDIELVIAGHGPLSD 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 213 IPRNIRKivkedhpENVLFPGYIRGEIIEGAYSGADLFFFPS-YEETEGIVVLEALASKQNVLVRDI--------PVYNG 283
Cdd:cd03823  234 ERQIEGG-------RRIAFLGRVPTDDIKDFYEKIDVLVVPSiWPEPFGLVVREAIAAGLPVIASDLggiaeliqPGVNG 306


                 ..
gi 514902318 284 WL 285
Cdd:cd03823  307 LL 308
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
120-275 4.96e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 44.78  E-value: 4.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 120 LITPTPYSKQLLESYGIRVPIQAISNGIDLEKYRPDPmkEQKFREYFKLSPDQKVIICVGLFFERKGIIDFVEIAKKMPE 199
Cdd:PRK15484 143 IIVPSQFLKKFYEERLPNADISIVPNGFCLETYQSNP--QPNLRQQLNISPDETVLLYAGRISPDKGILLLMQAFEKLAT 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 200 ------------YTFIWFGHVPMYSipRNIRKIVKEDHPENVLFPGyIRGEIIEGAYSGADLFFFPS-YEETEGIVVLEA 266
Cdd:PRK15484 221 ahsnlklvvvgdPTASSKGEKAAYQ--KKVLEAAKRIGDRCIMLGG-QPPEKMHNYYPLADLVVVPSqVEEAFCMVAVEA 297


                 ....*....
gi 514902318 267 LASKQNVLV 275
Cdd:PRK15484 298 MAAGKPVLA 306
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 113-269 1.04e-04

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 43.77  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 113 LYQKADYLITPTPYSKQLLESYgIRVPIQAISNgidlekyrpdPMKEQKFREYFKLSpdQKVIICVGLFFERKGI---ID 189
Cdd:cd03820  135 LYKRADKIVVLTEADKLKKYKQ-PNSNVVVIPN----------PLSFPSEEPSTNLK--SKRILAVGRLTYQKGFdllIE 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318 190 -FVEIAKKMPEYTFIWFGHVPMYsiPRNIRKIVKEDHPENVLFPGYIRGeiIEGAYSGADLFFFPSYEETEGIVVLEALA 268
Cdd:cd03820  202 aWALIAKKHPDWKLRIYGDGPER--EELEKLIDKLGLEDRVKLLGPTKN--IAEEYANSSIFVLSSRYEGFPMVLLEAMA 277


                 .
gi 514902318 269 S 269
Cdd:cd03820  278 Y 278
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
51-146 2.86e-03

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 37.77  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318   51 EKEDYDILHINTYGINSHNMVNKARReGKKVVYHAHSTEEDfrnsfIGSNQLSPIVKKYLVGLYQKADYLITPTPYSKQL 130
Cdd:pfam13579  68 RAERPDVVHAHSPTAGLAARLARRRR-GVPLVVTVHGLALD-----YGSGWKRRLARALERRLLRRADAVVVVSEAEAEL 141

                          90
                  ....*....|....*..
gi 514902318  131 LESYGI-RVPIQAISNG 146
Cdd:pfam13579 142 LRALGVpAARVVVVPNG 158
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 83-175 2.87e-03

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 39.27  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 514902318  83 YHAHSTEE----DFRNSFIGSNQLSPIVKKYLVGLYQkADYLITPTPYSKQLLESYgIRVPIQAISNGIDLEKYRPDPMK 158
Cdd:cd03818  122 YRAEGADVgfdpEFPLDLMIRCRLRNRNIALLLSLEQ-ADLGVTPTRWQRSLFPAA-YRDRISVIHDGVDTDRLAPDPAA 199

                         90
                 ....*....|....*..
gi 514902318 159 EQKFREYFKLSPDQKVI 175
Cdd:cd03818  200 RLRLLNGTELKAGDPVI 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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