|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
5-373 |
6.64e-68 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 218.96 E-value: 6.64e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 5 VYILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVF 84
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 85 SAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIA 164
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 165 ILTAIIMITVWFTMERLAPAPIVPL---KTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIY 241
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLgllSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 242 GIFGLAAVAGGGLGGAVSDKWnPSSSVITMIALFFVSMIAMPFGVHLPFVVFlLLMIIWSALSWAVSPAQSNLIIHSARD 321
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRG-GRRALLIALLLLAAALLLLTLLGPSPLLLL-VGLVLWGLGFFAAHSALQTRVLRLAPE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 515135555 322 TSDILISTNAAISHVGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLFCSL 373
Cdd:cd17324 319 ARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
5-378 |
4.07e-49 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 170.46 E-value: 4.07e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 5 VYILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVF 84
Cdd:PRK03545 11 VVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 85 SAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIA 164
Cdd:PRK03545 91 SALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 165 ILTAIIMITVWFTMERLAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIF 244
Cdd:PRK03545 171 GGALITLLLLIKLLPLLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENFATLLLLLF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 245 GLAAVAGGGLGGAVSDKwNPSSSVITMIALFFVSMIAMPFGVHLPfVVFLLLMIIWSALSWAVSPAQSNLIIHSARDTSD 324
Cdd:PRK03545 251 GGAGIIGSVLFSRLGNR-HPSGFLLIAIALLLVCLLLLLPAANSE-WHLSVLSIFWGIAIMCIGLAMQVKVLKLAPDATD 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 515135555 325 ILISTNAAISHVGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLFCSLYAVTR 378
Cdd:PRK03545 329 VAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAALVWSILIFRR 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-321 |
1.30e-35 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 133.56 E-value: 1.30e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 5 VYILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVF 84
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 85 SAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIA 164
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 165 ILTAIIMITVWFTMERLAPAPIVPLKTQVKA-LRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGI 243
Cdd:COG2814 172 VLALLALLLLLRLLPESRPAARARLRGSLRElLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLAL 251
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515135555 244 FGLAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHlpFVVFLLLMIIWSALSWAVSPAQSNLIIHSARD 321
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS--LWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
1-373 |
9.97e-28 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 112.49 E-value: 9.97e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 1 MNKKVYILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLL 80
Cdd:PRK10091 1 MKKVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 81 SNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVF 160
Cdd:PRK10091 81 GNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 161 VMIAILTAIIMITVWFTMERLAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTII 240
Cdd:PRK10091 161 LLIAVFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 241 YGIFGLAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLPfVVFLLLMIIWSALSWAVSPAQSNLIIHSAR 320
Cdd:PRK10091 241 MMLVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIVLALLMLFFFGGMK-TASLIFAFICCAGLFALSAPLQILLLQNAK 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 515135555 321 DTSDILISTNAAISHVGIAIGSYVGGIVVNQ-YSVIYNGWVGSIFVLLGLFCSL 373
Cdd:PRK10091 320 GGELLGAAGGQIAFNLGSAIGAYCGGMMLTLgLAYNYVALPAALLSFAAMSSLL 373
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
29-383 |
1.66e-23 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 100.73 E-value: 1.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 29 IADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFI 108
Cdd:COG2223 31 LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 109 IVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTMERL----APA 184
Cdd:COG2223 111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPpagaAAA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 185 PIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAAVAGGGLGGAVSDKWNP 264
Cdd:COG2223 191 AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 265 SSSVITMIALFFVSMIAMPFgVHLPFVVFLLLMIIWSALSWAVSPAQSNLIihsARDTSDILISTNAAISHVGIAIGSYV 344
Cdd:COG2223 271 RRVLLIVFALMALGLLLLAL-ALGSLWLFLVLFLLLGLALGGGNGAVFALV---PDIFPTKNAGAVYGLVGAAGGLGGFL 346
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 515135555 345 GGIVVNQYSVIYNG-----WVGSIFVLLGLFCSLYAVTRTESTA 383
Cdd:COG2223 347 GPLLFGALLDATGSytaafLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-370 |
4.14e-23 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 99.19 E-value: 4.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAY 87
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 88 SSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILT 167
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 168 AIIMITVWFTMERLAPAPIVPLKTQVKA-------LRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTII 240
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLrsglrllLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 241 YGIFGLAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHlpFVVFLLLMIIWSALSWAVSPAQSNLIIHSAR 320
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLGLGLVFPATLALLADIVP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 515135555 321 DTSD-ILISTNAAISHVGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLF 370
Cdd:cd17325 319 PEGRgTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
8-342 |
9.86e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.18 E-value: 9.86e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDL-IADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSA 86
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 87 YSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAIL 166
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 167 TAIIMITVWFTMERLAPAPIVPLKTQVKALRNKKMLAIH------LATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTII 240
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRdpvlwlLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 241 YGIFGLAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLP-FVVFLLLMIIWSALSWAVSPAQSNLIIHSA 319
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLsSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 515135555 320 -RDTSDILISTNAAISHVGIAIGS 342
Cdd:pfam07690 321 pKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
5-370 |
1.29e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 94.94 E-value: 1.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 5 VYILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVF 84
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 85 SAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGnALGWRQVFVMIA 164
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 165 ILTAIIMITVWFTM----ERLAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTII 240
Cdd:cd17474 160 ALIPVAFLAILFLLpepkEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 241 YGIFGLAAVAGGGLGGAVSDK-WNPSSSVITMIALFFVSMIAMPFGVHLPFvvFLLLMIIWSALSWAVSPAQSNLIIHSA 319
Cdd:cd17474 240 FAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALSLLLLGFVPSLAL--LLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 515135555 320 -RDTSDILISTNAAISHVGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLF 370
Cdd:cd17474 318 pEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-380 |
5.81e-21 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 93.01 E-value: 5.81e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 7 ILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSA 86
Cdd:COG2271 14 LLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 87 YSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAIL 166
Cdd:COG2271 94 FATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 167 TAIIMITvwftmerlapapivplktqvkalrnkKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGL 246
Cdd:COG2271 174 GLLLALL--------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 247 AAVAGGGLGGAVSDKWNpSSSVITMIALFFVSMIAMPFGVHLP--FVVFLLLMIIWSALSWAVSPAQSNLIIHSARDTSD 324
Cdd:COG2271 228 AGIVGSLLGGWLSDRLG-RRRKLVLAIGLLLAALALLLLALLPspALAIALLFLAGFGLGGAFGLLWALAAELFPKKARG 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 515135555 325 ILISTNAAISHVGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLFCSLYAVTRTE 380
Cdd:COG2271 307 TASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
41-179 |
3.09e-18 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 80.39 E-value: 3.09e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 41 GYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMV 120
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 515135555 121 KPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTME 179
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
8-349 |
1.79e-16 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 79.91 E-value: 1.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAY 87
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 88 SSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILT 167
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 168 AIIMItvwftmerLAPApivplktqvkalrnkkMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLA 247
Cdd:cd17321 161 LVALL--------LART----------------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 248 AVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVH----LPFVVFLLLMIIWSALSWAvsPAQSNLIIHSARDTS 323
Cdd:cd17321 217 MLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGAdssvWLLLPGLVLLGLGLGLFAT--PLTNAALSSVPKEKA 294
|
330 340
....*....|....*....|....*.
gi 515135555 324 DILISTNAAISHVGIAIGSYVGGIVV 349
Cdd:cd17321 295 GAASGILNTARQLGGALGVALLGALL 320
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
8-374 |
4.88e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 78.62 E-value: 4.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAY 87
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 88 SSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILI--GNALGWRQVFVMIAI 165
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 166 LTAIIMITVWFTMERLAPAPIVPLKTQ---------VKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMM 236
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEAssksvlkllKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 237 VTIIYGIFGLAAVAGGGLGGAVSDKWNPSSSVItMIALFFVSMIAMPFGVHLPFVVFLLLMIIWSALSWAVSPAQSNLII 316
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL-LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 515135555 317 HSARDTSD-ILISTNAAISHVGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLFCSLY 374
Cdd:cd06174 320 ELFPPEIRgTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
8-373 |
1.12e-15 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 77.62 E-value: 1.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAY 87
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 88 SSGYYMLLIGRILAAASGSfIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILT 167
Cdd:cd17504 81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 168 AIIMITVwftmerlapaPIVPLKTqvkaLRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLA 247
Cdd:cd17504 160 VLLAALV----------PLIDLRL----LRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 248 AVAGGGLGGAVSDKWNPSSSV-------ITMIALFFVSMIAMPFGVhLPFVVFLLLMIIWSALSWAVSPaqsNLIIHSA- 319
Cdd:cd17504 226 GALVMLIAGPLAGRLIARVGPrrvlligLVISAVGLLLLALLHSSL-WALVVALLLIGIGLGLAFASLP---NIVVESVp 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515135555 320 RDTSDILISTNAAISHVGIAIGSYVGGIVVNQYSVI-------------YNGWVGSIFVLLGLFCSL 373
Cdd:cd17504 302 PDRTGIATGMNTVLRTIGSAIGPAIAGAILTTYTVSitsggvptegayvLAFLIGAALALAALLLSL 368
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-284 |
1.36e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 76.39 E-value: 1.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 7 ILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSA 86
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 87 YSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAIL 166
Cdd:COG0477 98 LAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 167 TAIIMITVWFTMERLAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGL 246
Cdd:COG0477 178 GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALL 257
|
250 260 270
....*....|....*....|....*....|....*...
gi 515135555 247 AAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPF 284
Cdd:COG0477 258 LLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
29-299 |
1.85e-14 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 74.15 E-value: 1.85e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 29 IADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFI 108
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 109 IVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTM------ERLA 182
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLpetlpeEKRK 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 183 PAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAAVAGGGLGGAVSDKW 262
Cdd:cd17320 185 PLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRF 264
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 515135555 263 NPSSSVITMIALFFVS---MIAMPFGVHLPFVVFLLLMII 299
Cdd:cd17320 265 GPRRLLRLGLLLLLAAalvLLLAALLGGLSLWPLVAPLFL 304
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
5-178 |
7.19e-14 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 72.22 E-value: 7.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 5 VYILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVF 84
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 85 SAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIA 164
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170
....*....|....
gi 515135555 165 ILTAIIMITVWFTM 178
Cdd:cd17323 161 IISGFCLILIFLFL 174
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
5-240 |
2.95e-13 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 70.72 E-value: 2.95e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 5 VYILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVF 84
Cdd:PRK10213 22 VFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLTLSCLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 85 SAYSSGYYMLLIGR-ILAAASGSFIiVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMI 163
Cdd:PRK10213 102 VSFANSFSLLLIGRaCLGLALGGFW-AMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFNAA 180
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515135555 164 AILTAIIMITVWFTMERLAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTII 240
Cdd:PRK10213 181 AVMGVLCIFWIIKSLPSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDGLTLV 257
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
8-376 |
3.06e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 3.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAY 87
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 88 SSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILT 167
Cdd:cd17489 81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 168 AIIMITVWFTMERLAPAP--IVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIfg 245
Cdd:cd17489 161 LLALLLVFLVKDPPPVAAeeAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAI-- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 246 lAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGvHLPFVVFLLLMIIWSALSWAVSPAQSNLIIHSARDTSDI 325
Cdd:cd17489 239 -ALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA-GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 515135555 326 LISTNAAISHVGIAIGSYVGGIVVN--QYSVIYngWVGSIFVLLGLFCSLYAV 376
Cdd:cd17489 317 ANGTFFIFFDLGIGLGGLLLGLVAElfGYRAMF--LLAAVVVLLALVLYIFLL 367
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
8-299 |
5.38e-13 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 69.53 E-value: 5.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAY 87
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 88 SSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILT 167
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 168 AIImitvwftmerLAPAPIVPLktqvKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTM---MVTIIYGIf 244
Cdd:cd17503 161 ILA----------LLLAPLLDL----RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFesgLVLAPGGL- 225
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 515135555 245 glAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAM-PFGVHLPFVVFLLLMII 299
Cdd:cd17503 226 --ASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLaFLTPDTSLWLIILPLFI 279
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
6-382 |
3.33e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.19 E-value: 3.33e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 6 YILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFS 85
Cdd:COG0738 11 IAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLF 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 86 AYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVkPKYQGRAIGIVFMGISGSLVLGIPLG---ILIGNALGWRQVFVM 162
Cdd:COG0738 91 ALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGgllILLGLSLSWHLPYLI 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 163 IAILTAIIMITVWFT----MERLAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVT 238
Cdd:COG0738 170 LAVLLLLLALLFLRSklpeIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 239 IIYGIFGLAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLPFVVFLLlmIIWSALSWAVSPAQSNLIIHS 318
Cdd:COG0738 250 LGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGL--ALVGLGLSLMFPTIFSLALDG 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515135555 319 ARDTSDILISTNAAISHVGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLFCSLYAVTRTEST 382
Cdd:COG0738 328 LGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
22-378 |
9.37e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 65.76 E-value: 9.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 22 LGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYML--LIGRI 99
Cdd:cd17355 22 FGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLylLWGLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 100 LAAASGSFIIVLSTTMASRmVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTME 179
Cdd:cd17355 102 GGGGAGTLAAVAFATVAAW-WFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 180 R----------LAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQEtLGLNTMMVTIIYGIFGLAAV 249
Cdd:cd17355 181 RrpadlalrayDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNI 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 250 AGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLPFVVFLLLMIIwsALSW-AVSPAQSNLIIHS-ARDTSDILI 327
Cdd:cd17355 260 VGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALF--GLGWgATVPLTAALAARYfGARSYGTLF 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 515135555 328 STNAAISHVGIAIGSYVGGIVVNQYSVIynGWVGSIFVLLGLFCSLYAVTR 378
Cdd:cd17355 338 GLVFAPHQLGSALGPWLGGLLYDRTGSY--TAAWALAVALGLIAALLVLPI 386
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
25-373 |
2.21e-11 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 64.94 E-value: 2.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 25 ILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAAS 104
Cdd:cd17353 25 FNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 105 GSFIIVLSTTmaSRMVK--PKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTMeRLA 182
Cdd:cd17353 105 GAGIGYITPV--STAVKwfPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLI-RDP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 183 PAPIVP---------------LKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLA 247
Cdd:cd17353 182 PKGWVPpgvdplannaensprDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIF 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 248 AVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLPFVVFLLLMIIWSAL--SWAVSPAQsnliihsardTSDI 325
Cdd:cd17353 262 NGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYggGFALFPAL----------TADF 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 515135555 326 LISTNAAISH--------VGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLFCSL 373
Cdd:cd17353 332 FGTKNAGTNYgllytakgVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALAL 387
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
29-369 |
7.62e-11 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 63.02 E-value: 7.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 29 IADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFI 108
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 109 IVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNaLGWRQVFVMIAILTAIIMITVWFTMERLAPAPIVP 188
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 189 LKTQVK-----ALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAAVAGGGLGGAVSDKWN 263
Cdd:cd17329 185 EKTEILrgykiVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 264 PSSSVITMIALFFVSMIAMPFGVHlpFVVFLLLMIIWSALSWAVSPAQSNLIIHSARDTSDIL-ISTNAAISHVGIAIGS 342
Cdd:cd17329 265 LRKILMIGILLFAIGFAVLAFANT--LAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSyMGFYALAWGLGRAIGP 342
|
330 340
....*....|....*....|....*..
gi 515135555 343 YVGGIVVNQYSVIYNGWVGSIFVLLGL 369
Cdd:cd17329 343 LVGGLLLDLLGPGLPWLILAALGLIAA 369
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
22-349 |
1.10e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 62.59 E-value: 1.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 22 LGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILA 101
Cdd:cd17319 22 ISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 102 AASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTMerl 181
Cdd:cd17319 102 GVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL--- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 182 apapivplktqvkalrnKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAAVAGGGLGGAVSDK 261
Cdd:cd17319 179 -----------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 262 WNPSSSVITMIALFFVSMIAMPFGVHL--PFVVFLLLMIIWSALSWAVSPAQSNLIIHSARDTSDILISTNAAISHVGIA 339
Cdd:cd17319 242 LLRGARRLVIIIGLLLAAVGLLLAYLTtsPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGF 321
|
330
....*....|
gi 515135555 340 IGSYVGGIVV 349
Cdd:cd17319 322 VAPLLIGYLV 331
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
22-369 |
2.36e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.81 E-value: 2.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 22 LGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILA 101
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 102 AASGSFIIVLSTTMASRMVkPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMItVWFTMERL 181
Cdd:COG2807 117 GAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALL-LWLPLLRR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 182 APAPIVPLKTQVKA---LRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQEtLGLNTMMVTIIYGIFGLAAVAGGGLGGAV 258
Cdd:COG2807 195 RPAAAAAAPAAASLrslWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 259 SDKW-NPSSSVITMIALFFVSMIAMPFGVHLPFVVFLLLMIIWSALSWAVSPAQSNLIIHSARDTSDiLISTNAAISHVG 337
Cdd:COG2807 274 ADRLgDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAA-LSGMAQSVGYLL 352
|
330 340 350
....*....|....*....|....*....|..
gi 515135555 338 IAIGSYVGGIVVNQysviYNGWVGSIFVLLGL 369
Cdd:COG2807 353 AALGPLLVGALHDA----TGSWTAALLLLAAL 380
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
4-298 |
4.93e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.66 E-value: 4.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 4 KVYILAIASFVVGTVELIlGGILDLIADAFH-VSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSN 82
Cdd:cd17473 1 LITLLLASTLTVMAGAAI-APALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 83 VFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGnALGWRQVFVM 162
Cdd:cd17473 80 VAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 163 --IAILTAIIMITVWFTMERLAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTII 240
Cdd:cd17473 159 ylLALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 515135555 241 YGIFGLAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLPFVVFLLLMI 298
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILA 296
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
30-349 |
1.04e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.92 E-value: 1.04e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 30 ADAFHVSLAKAGYLISIYSFVYALSAPILL----NVTAKIERKKVYM------WTLFIFLLSNVFSAYSSGYY-MLLIGR 98
Cdd:COG2211 38 TDVLGLSAALVGLILLVARLWDAITDPLIGalsdRTRTRWGRRRPWIligaipLALSFVLLFTAPDLSPTGKLiYALVTY 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 99 ILAAASGSFIIVLSTTMASRMVK-PKYQGRAIGIVFMGISGSLVLGIPLGILI------GNALGWRQVFVMIAILTAI-I 170
Cdd:COG2211 118 LLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLaF 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 171 MITVWFTMERLAPA-PIVPLKTQVKAL-RNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAA 248
Cdd:COG2211 198 LLTFFGTKERPVPEeEKVSLKESLKALlKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 249 VAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLPFVVFLLLMIIWSALSWAVSPAQSNLI--------IHSAR 320
Cdd:COG2211 278 LLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdydeWKTGR 357
|
330 340
....*....|....*....|....*....
gi 515135555 321 DTSDILISTNAAISHVGIAIGSYVGGIVV 349
Cdd:COG2211 358 RREGLYFGIFTFAIKLGQALAGALAGLLL 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-176 |
3.14e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.97 E-value: 3.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 1 MNKKVYILAIASFVVGTVELILGGILDL-IADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFL 79
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 80 LSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQV 159
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
170
....*....|....*..
gi 515135555 160 FVMIAILTAIIMITVWF 176
Cdd:cd17325 357 FLAAAALLLLAAVLFLL 373
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
8-178 |
3.68e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 57.57 E-value: 3.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDLIADAFHvSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAY 87
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 88 SSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIvFMGISG-SLVLGIPLGILIGNALGWRQVF---VMI 163
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGY-IGAVFGiASVAGPLIGGAFTDHLSWRWCFyinLPI 158
|
170
....*....|....*
gi 515135555 164 AILTAIIMITVWFTM 178
Cdd:cd17502 159 GGLALALLRTILLSS 173
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
1-178 |
3.82e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 57.75 E-value: 3.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 1 MNKKVYILAIASFVVGTVE----LILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLF 76
Cdd:TIGR00895 11 LSRYQWRAIILSFLIMLMDgydlAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 77 IFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGW 156
Cdd:TIGR00895 91 LFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGW 170
|
170 180
....*....|....*....|..
gi 515135555 157 RQVFVMIAILTAIIMITVWFTM 178
Cdd:TIGR00895 171 RSLFYVGGIAPLLLLLLLMRFL 192
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
64-373 |
5.46e-09 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 57.23 E-value: 5.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 64 KIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAaSGSFIIVLSTTMASRmVKPKYQGRAIGIVFMGISGSLVLG 143
Cdd:cd17472 58 RIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLADL-TREENRTKAMALIGASIGIAFAIS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 144 IPLGILIGNALGWRQVFVMIAILTAIIMITVWFTMERLAPAPIVPLKTQVKA---LRNKKMLAIHLATLFVlagHLTLYA 220
Cdd:cd17472 136 MVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLkklLKNKRLLRLDFSIFIL---HFVLMA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 221 YFT--PFLQETLGLNTMMVTIIYGIFGLAAVAGGGLGGAVSDKWNPSSSVITM-IALFFVSMIAMPFGVHLPFVVFLLLM 297
Cdd:cd17472 213 FFYilPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSsILLIAVGFLLLLFAATSLWLLIIGLI 292
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515135555 298 IIWSALSWAVSPAQSNLIIHSARDTSDILISTNAAISHVGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLFCSL 373
Cdd:cd17472 293 IFFIGFNLLEALLPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSF 368
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-185 |
6.90e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 57.20 E-value: 6.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 2 NKKVYILAIASFVVGTVELILGGIL-DLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLL 80
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFIGFSSWLpPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMAL 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 81 SNVFSAYSSG-YYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFM-GISGSLVLGIPLGILIGNALGWRQ 158
Cdd:COG2223 284 GLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAaGGLGGFLGPLLFGALLDATGSYTA 363
|
170 180
....*....|....*....|....*..
gi 515135555 159 VFVMIAILTAIIMITVWFTMERLAPAP 185
Cdd:COG2223 364 AFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
21-348 |
1.91e-08 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 55.70 E-value: 1.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 21 ILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRIL 100
Cdd:cd17328 17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 101 AAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNA-LGWRQVFVMIAILTAIIMITVWFTME 179
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 180 ---RLAPAPIVPLKTQVKA--------LRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAA 248
Cdd:cd17328 177 eppRGAAEGGVMAKSTATSfladlkalAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAIT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 249 VAGGGL-----------GGAVSDKWNPSSSVITMIALFFVSMIAMPFGVH--LPFVVFLLLMIIWSALSWAVSPA-QSNL 314
Cdd:cd17328 257 CIAGVLgvllggiladrLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSnlLLAWVLLFLGEFLLSLNWAPVFAiLLYV 336
|
330 340 350
....*....|....*....|....*....|....*
gi 515135555 315 IIHSARDT-SDILISTNAAIshvGIAIGSYVGGIV 348
Cdd:cd17328 337 VIPTRRSTaSAIQILLSHLL---GDAGSPYLIGLI 368
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
40-370 |
2.75e-08 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 54.89 E-value: 2.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 40 AGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVlSTTMASRM 119
Cdd:cd17330 36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADI 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 120 VKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTMERLAPapivplktqvkalrnk 199
Cdd:cd17330 115 TDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRR---------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 200 kmlaIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAAVAGGGLGGAVSDKwNPSSSVITMIALF--FV 277
Cdd:cd17330 179 ----LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAK-RLGERKLLRLGLLlaII 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 278 SMIAMPFGVhLPFVVFLLLMIIWSALSWAVSPAQSNLIIHSARDTSDILISTNAAISHVGIAIGSYVGGIVVNQYSVIYN 357
Cdd:cd17330 254 GLLLLPFAS-SVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVP 332
|
330
....*....|...
gi 515135555 358 GWVGSIFVLLGLF 370
Cdd:cd17330 333 FLLAAGLLLIALF 345
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
28-305 |
6.03e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.17 E-value: 6.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 28 LIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSF 107
Cdd:cd17475 21 FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 108 IIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWF------TMERL 181
Cdd:cd17475 101 VQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLfyreppAASAA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 182 APAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAAVAGGGLGGAVSDK 261
Cdd:cd17475 181 TESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDR 260
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 515135555 262 WNPSSSVITM------IALFFVSMIAMPFGVHLPFVVFLLLMIIWSALSW 305
Cdd:cd17475 261 VFGGRRRPVLvitaaiAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGW 310
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
5-311 |
1.12e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.99 E-value: 1.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 5 VYILAIASFVVGTVELILGGILDLIADAF--HVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSN 82
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 83 VFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNAL----GWRQ 158
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdwGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 159 VFVMIAILTAIIMITvwftmerlapapivplktqvkalrNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVT 238
Cdd:cd17316 161 LFLIGALPALLALLL------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515135555 239 IIYGIFGLAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLPFVVFLLLMIIWSALSWAVSPAQ 311
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGAL 289
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
8-299 |
7.95e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 7.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAY 87
Cdd:cd17478 1 LSLGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 88 SSGYYMLLIGRILAAASGSFIIVLSTTMASrMVKPKYQGRAIGIVFMGISGSLVLGiPLGILIGNALGWRQVFVMIAILT 167
Cdd:cd17478 81 APNYWLLLLLVALAGIGSAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALG-PLIAAALVALFGGLGLLILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 168 AIIMITVWFTMERLAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAY----FTPFLQETLGLNTMMVTIIYGI 243
Cdd:cd17478 159 GLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSslttFLPFYLVQRGYSLVFAGLLLSL 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 515135555 244 FGLAAVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFgvHLPFVVFLLLMII 299
Cdd:cd17478 239 FLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL--TPGIWSYILLVLA 292
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
67-374 |
8.46e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 50.68 E-value: 8.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 67 RKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASrMVKPKYQGRAIGIVFMGISGSLVLGIPL 146
Cdd:cd17490 61 RKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAS-YFPPDEAAKAMGLINLVNNLGQLIAFLI 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 147 GILIGNALGWRQVFVMIAILTAIIMITVWFTMERLAPAPIVP--LKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTP 224
Cdd:cd17490 140 GGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLteLKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTP 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 225 FLQETLGLNTMMVTIIYGIFGLA-AVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLpFVVFLLLMIIWSAL 303
Cdd:cd17490 220 LIAKQLGASSFQLGLLSIIYLLPnALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNL-TLLYLLQALNGFGT 298
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515135555 304 SWAVSPAQSNLIIHSARDTSDILISTNAAISHVGIAIGSYVGGIVVNQYSVIYNGWVGSIFVLLGLFCSLY 374
Cdd:cd17490 299 GILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-176 |
1.34e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 2 NKKVYILAIASFVVGTVELILGGILDLIA-DAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLL 80
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAkEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 81 SNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVF 160
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVF 366
|
170
....*....|....*.
gi 515135555 161 VMIAILTAIIMITVWF 176
Cdd:cd06173 367 LLAGALLLLAALLLLL 382
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
41-369 |
1.82e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 49.56 E-value: 1.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 41 GYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASrMV 120
Cdd:cd17388 41 GVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIAD-VT 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 121 KPKYQGRAIGIVFMGISGSLVLGIPLGILIGnALGWRQVFVMIAILTAIIMITVWFTM------ERLAPAPIVPLKTQV- 193
Cdd:cd17388 120 PPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLGLFVLpeslppERRRAFRWRRANPFGs 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 194 -KALRNKKMLAIHLATLFV--LAGHL--TLYAYFTpflQETLGLNTMMVTIIYGIF-GLAAVAGGGLGGAVSDKWNPSSS 267
Cdd:cd17388 199 lRWLTGFPGLLGLLAVFFLiqLIGQVpaTTWVLFT---EDRFDWSPTMVGLSLAVFgLLHALFQAFVTGPIAKRLGEKRA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 268 VITMIALFFVSMIAMPFGVHlPFVVFLLLMIIwsALSWAVSPA-QSNLIIHSARDTSDILISTNAAISHVGIAIGSYVGG 346
Cdd:cd17388 276 ILLGLAADALGFLLLAFATQ-GWMVFPILILL--ALGGIAGPAlQGLLSRQVPENEQGELQGVLTSLTSLTSIIGPLLFT 352
|
330 340
....*....|....*....|....*.
gi 515135555 347 IVVNQYSVIYNGWV---GSIFVLLGL 369
Cdd:cd17388 353 GIFAASPATWPGLAwiiGAALYLICL 378
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-178 |
1.04e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.19 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 20 LILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRI 99
Cdd:cd17365 16 AVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515135555 100 LAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTM 178
Cdd:cd17365 96 LTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL 174
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
9-178 |
1.69e-05 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 46.41 E-value: 1.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 9 AIASFVVGTVELILGGILDLIADAFHVSLAK--AGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSA 86
Cdd:cd17315 3 ALGGLLFGYDLGVINGALLYIAKDLGFGLSTslQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 87 YSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNAL-GWRQVFVMIAI 165
Cdd:cd17315 83 LAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPpGWWRLMFALAA 162
|
170
....*....|...
gi 515135555 166 LTAIIMITVWFTM 178
Cdd:cd17315 163 VPALLQLLLMFFL 175
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
7-299 |
1.70e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.48 E-value: 1.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 7 ILAIASFVVG-TVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFS 85
Cdd:cd17341 2 HLSWLSFFLGfMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 86 AYS-SGYYMLLIGRILAAASGSfIIVLSTTMASRMVKPKYQGRAIGIVF----MGISGSLVLGIPL---GILIGNALGWR 157
Cdd:cd17341 82 ALAvSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIagaIVFDGGFVGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 158 QVFVMIAILTAIIMITVWFTMERLAPAPIVP---LKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNT 234
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTGKASAlefLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPL 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515135555 235 MMVTIIYGIFGLAAVAGGGLGGAVSDKWNPSSS---VITMIALFFVSMIAMPFGVHLPFVVFLLLMII 299
Cdd:cd17341 241 VTAGILAALFPLAGALARPAGGWLSDRFGGRRRlwwLFIVMTIGAALLSLSLPTSGTNLVLFLALFVA 308
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
41-176 |
2.32e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 46.11 E-value: 2.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 41 GYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYS---SGYYMLLIGRILAAASGSFIIVLSTTMAS 117
Cdd:pfam00083 49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515135555 118 RMVKPKYQGRAIGIVFMGISGSLVLGIPLG---ILIGNALGWRQVFVMIAILTAIIMITVWF 176
Cdd:pfam00083 129 EIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPALLLIIGLLF 190
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
45-177 |
9.29e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.11 E-value: 9.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 45 SIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKY 124
Cdd:cd17317 32 TIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 515135555 125 QGRAIGIVFMGISGSLVLGIPLGILIGNalgWRQVFVMIAILTAIIMITVWFT 177
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLLLLWWL 161
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
2-174 |
1.12e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.72 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 2 NKKVYILAIASFVVGTV-ELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLL 80
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLfYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMAL 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 81 SNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIV----FMGISGSLVLGIPLGILIGNALGW 156
Cdd:cd17473 276 GFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVtsafFLGQFLSPLVLGPLVNLTGGLSGA 355
|
170
....*....|....*...
gi 515135555 157 RQVFVMIAILTAIIMITV 174
Cdd:cd17473 356 FLILGVLALVLAIVLLLL 373
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
8-299 |
1.64e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 43.32 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 8 LAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAY 87
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 88 SSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGiPLGILIGNALGWrQVFVMIAILT 167
Cdd:cd17477 81 TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGA-LPFLIAAVLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 168 AIIMITVWFTmerLAPAPIVPLKTQVKALRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLA 247
Cdd:cd17477 159 LLALVPLLLT---RRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLG 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 515135555 248 AVAGGGLGGAVSDKWNPSSSVITMIALFFVSMIAMPFGVHLPFVVFLLLMII 299
Cdd:cd17477 236 GLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLW 287
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
46-370 |
3.62e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 3.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 46 IYSFVYALSAPILLNVTAKIERKKVYMWT-----LFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMV 120
Cdd:cd06173 42 AFFLPFLLFSPFAGVLADRFDRRRLLILAdllraLLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELV 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 121 KPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTMERLAPAPIVPLKTQVKAL---- 196
Cdd:cd06173 122 PKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLregl 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 197 ----RNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAAVAGGGLGGAVSDKWNPSSSVITMI 272
Cdd:cd06173 202 rylrRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 273 ALFFVSMIAMPFgVHLPFVVFLLLMIIWSALSWAVSPAQSNLIIHSARDTSDILISTNAAISHVGIAIGSYVGGIVVNQY 352
Cdd:cd06173 282 LLLGLALLVLGL-SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
330
....*....|....*...
gi 515135555 353 SVIYNGWVGSIFVLLGLF 370
Cdd:cd06173 361 GLSAVFLLAGALLLLAAL 378
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
91-185 |
8.94e-04 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 41.20 E-value: 8.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 91 YYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGwrqvFVMIAILTAII 170
Cdd:PRK12382 112 FALLVVGRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAGAPLGLLLHSHFG----FAALALTTMVL 187
|
90
....*....|....*
gi 515135555 171 MITVWFTMERLAPAP 185
Cdd:PRK12382 188 PLLAWAFNGTVRKVP 202
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
5-179 |
1.01e-03 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 41.02 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 5 VYILAIASFVVGTVELILGGILDLIAD----AFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLL 80
Cdd:cd17358 4 TFVANLGSFSFGIAVGWSSPALPSLMSdnslSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 81 SNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIvfmgISGSLVLGIPLGILIGNALGWRQVF 160
Cdd:cd17358 84 GWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSL----NQLLVNIGILLGYVLGSFLPWRTLA 159
|
170
....*....|....*....
gi 515135555 161 VMIAILTAIIMITVWFTME 179
Cdd:cd17358 160 LIGAIPPVVFLILLFFIPE 178
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
4-172 |
1.17e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 4 KVYILAIASFVVGTVELILggiLDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNV 83
Cdd:cd17370 203 WLYLLAVALFALGNFSFAF---LILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 84 FSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMI 163
Cdd:cd17370 280 GFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFS 359
|
....*....
gi 515135555 164 AILTAIIMI 172
Cdd:cd17370 360 AVLALIALL 368
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
25-241 |
1.27e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 40.71 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 25 ILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAAS 104
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 105 GSFIIVLSTTMASRMVKPkyqGRAIGIVFMGISGSLVLGIPLGILIGNALG----WRQVFVMIAILTAIIMITVWFTMer 180
Cdd:cd17476 100 PAFLLPNAMALLGRTYPP---GPRKNIVFSLFGATAPLGFALGGVFGGLFAqlawWPWIFWFLAILAAIVAVAAIFWT-- 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515135555 181 lapapivplktqvkalrNKKMLAIHLATLFVLAGhLTLYAYFTPFLQETLGLNTMMVTIIY 241
Cdd:cd17476 175 -----------------SPSFIAVLLAVFLGWAS-FGIWVFYATQYFQNVRGYSPLLTSAR 217
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
29-160 |
1.29e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.72 E-value: 1.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 29 IADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRI-----LAAA 103
Cdd:PRK11551 41 MAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLltgvgLGGA 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 515135555 104 SGSFIivlstTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVF 160
Cdd:PRK11551 121 LPNLI-----ALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIF 172
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
40-188 |
1.45e-03 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 40.25 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 40 AGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVF---SAYSSG-----YYMLLIGRILAAASGSFIIVL 111
Cdd:PRK05122 53 AGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLyllAGLLAAwpvlsLLLLLLGRLLLGIGESLAGTG 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515135555 112 STTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGwrqvFVMIAILTAIIMITVWFTMERLAPAPIVP 188
Cdd:PRK05122 133 SILWGIGRVGALHTGRVISWNGIATYGALAIGAPLGVLLYHWGG----LAGLGLLIMLLALLGLLLARPRPAVPPVK 205
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
40-379 |
1.52e-03 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 40.29 E-value: 1.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 40 AGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRM 119
Cdd:PRK09874 56 SGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFVPNANALIATQV 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 120 VKPKyQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIA-ILTAIIMITVWFTMERLAPAP---IVPLKTQVKA 195
Cdd:PRK09874 136 PRNK-SGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITAsVLFLCFLVTLFCIRENFQPVSkkeMLHMREVVTS 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 196 LRNKKM-LAIHLATLFVLAGHLTLYAYFTPFLQETLGlNTMMVTIIYGIFGLAAVAGGGLGG----AVSDKWNPSSSVIT 270
Cdd:PRK09874 215 LKNPKLvLSLFVTTLIIQVATGSIAPILTLYVRELAG-NVSNIAFISGMIASVPGVAALLSAprlgKLGDRIGPEKILIT 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 271 MIALFFVSMIAMPFgVHLPFVVFLLLMIIWSALSWAVSPAQSNLIIHSARDTSDILISTNAAISHVGIAIGSYVGGIVVN 350
Cdd:PRK09874 294 ALIFSVLLLIPMSF-VQTPLQLGILRFLLGAADGALLPAVQTLLVYNSSNQIAGRIFSYNQSFRDIGNVTGPLMGAAISA 372
|
330 340
....*....|....*....|....*....
gi 515135555 351 QYSVIYNGWVGSIFVLLGLFCSLYAVTRT 379
Cdd:PRK09874 373 NYGFRAVFLVTAGVVLFNAVYSWNSLRRR 401
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
5-299 |
1.55e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.47 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 5 VYILAIASFVVGTVELILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVF 84
Cdd:cd17314 5 LYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 85 SAYS-SGYYMLLIGRILAAASGSFIIVLSTTMASRMVkPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMI 163
Cdd:cd17314 85 LSYVfNSFPLSYACFVFIGAGTGILYGSAVLVTTQYF-PDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 164 AILTAIIMITVWFTMERLAPAPIVPLKTQVKA-------LRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMM 236
Cdd:cd17314 164 GILAAIVLSVVSLLGFKEPPDNQARLHVQKKKtqtmgeiFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSF 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515135555 237 VTIIYGIFGLAAVAGGGLGGAVSDKW-NPSSSVITMIALFFVSMIAMPFGVHLPFVVFLLLMII 299
Cdd:cd17314 244 VTKLMSIYGLFNAFGRLLWGIVADFFgGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSL 307
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
41-151 |
1.73e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 40.34 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 41 GYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSfIIVLSTTMASRMV 120
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKG-NVSLSTAIVADVT 145
|
90 100 110
....*....|....*....|....*....|.
gi 515135555 121 KPKYQGRaiGIVFMGISGSlvLGIPLGILIG 151
Cdd:cd17389 146 SPKKRSK--GMALIGVAFS--LGFIIGPMIG 172
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
38-179 |
1.76e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 40.38 E-value: 1.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 38 AKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMAS 117
Cdd:TIGR00898 127 WKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNT 206
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515135555 118 RMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIgnaLGWRQVFVMIAILTAIIMITVWFTME 179
Cdd:TIGR00898 207 EFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFI---PDWRWLQLAVSLPTFLFFLLSWFVPE 265
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
67-243 |
2.27e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 39.84 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 67 RKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMAsRMVKPKYQGR----AIGIVFMGISGSLVL 142
Cdd:cd17471 62 RKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALA-REYADRSSGRdatlFNSVLRAAFSLAWVI 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 143 GIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTMERLAPAPIVPLK--TQVKALRNKKMLAIHLATLFVLAGHLTLYA 220
Cdd:cd17471 141 GPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPasSLVKAPVNRRLLLLFAAFTLLFAANSMYII 220
|
170 180
....*....|....*....|...
gi 515135555 221 YFTPFLQETLGLNTMMVTIIYGI 243
Cdd:cd17471 221 AMPLYVTNELGGSESWVGLLFGL 243
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
20-210 |
2.27e-03 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.98 E-value: 2.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 20 LILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRI 99
Cdd:cd17371 16 LLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 100 LAAASGSFIIVLSTTMASRMVKPKYQGRAIGIVFMGIS-GSLVLGIPLGILIGNAL---GWRQVFvMIAILTAIImitVW 175
Cdd:cd17371 96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAvGWLLATLLAALLFPLLPpeiAWRVLF-LLGALPALL---VL 171
|
170 180 190
....*....|....*....|....*....|....*
gi 515135555 176 FtMERLAPAPivPLKTQVKALRNKKMLAIHLATLF 210
Cdd:cd17371 172 F-IRRFVKEP--PQWQAARAARRHFADRPSLRELF 203
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
74-177 |
2.71e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 39.63 E-value: 2.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 74 TLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSfIIVLSTTMASRMVKPKYQGRAIGIV-FMGISGSLVLGIPLGiLIGN 152
Cdd:cd17343 304 TVSLHLFRVHITSDSSELFILLLGFLIGFSLYG-PIAIFGVIANESAPSHLCGTSHAIVaLAANVGGVLAGLPFS-YIAK 381
|
90 100
....*....|....*....|....*
gi 515135555 153 ALGWRQVFVMIAILTAIIMITVWFT 177
Cdd:cd17343 382 HYDWRTAFLLLEILCAITVVILFLL 406
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
40-376 |
3.29e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 3.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 40 AGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAASGSFIIVLSTTMASRM 119
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIASQT 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 120 VKPKyQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFTM----ERLAPAPIVPLKTQVKA 195
Cdd:cd17391 118 PKEK-SGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVkedfKPVEKKKMVSTKEVWNS 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 196 LRNKKMLAIHLATLFVLAGHLTLYAYFTPFLQETLGLNTMMVTIIYGIFGLAAVAGGGLGGA----VSDKWNPSSsvITM 271
Cdd:cd17391 197 VPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLLSAPrlgkLGDRIGHHR--ILL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 272 IALFFVSMIAMPFGVHLPFVVFLLLMIIWSALSWAVSPAQSNLIIHSA--RDTSDILiSTNAAISHVGIAIGSYVGGIVV 349
Cdd:cd17391 275 GALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITpkEVAGRIF-GYNQSFQYLGNVAGPLLGSAIA 353
|
330 340
....*....|....*....|....*..
gi 515135555 350 NQYSVIYNGWVGSIFVLLGLFCSLYAV 376
Cdd:cd17391 354 AHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
30-176 |
3.50e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.14 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 30 ADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVF--SAYSSGYYMLLIGRILAAASGSF 107
Cdd:cd17318 48 APEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLtpLAARGGYGALIVLRILQGLAQGV 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515135555 108 IIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWF 176
Cdd:cd17318 128 TFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFF 196
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| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
21-176 |
5.63e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 38.70 E-value: 5.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 21 ILGGILDLIADAFHVSLAKAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRIL 100
Cdd:cd17359 19 VINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARII 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 101 AAASGSFIIVLSTTMASRMVKPKYQGRAIGIV-FMGISGSLV-------LGIPLGILIGNALGWRQVFVMIAILTAIIMI 172
Cdd:cd17359 99 GGLAVGGASALVPMYIAEVAPAEIRGRLVSLNqLMIVFGQLLayivnylIANAGGADWLGAEGWRWMLGLEAIPAILFLL 178
|
....
gi 515135555 173 TVWF 176
Cdd:cd17359 179 GMLF 182
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
25-177 |
8.59e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.01 E-value: 8.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515135555 25 ILDLIADAFHVSLAkAGYLISIYSFVYALSAPILLNVTAKIERKKVYMWTLFIFLLSNVFSAYSSGYYMLLIGRILAAAS 104
Cdd:cd17391 228 IRQLMGDASNLAFI-SGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLA 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515135555 105 GSFIIVLSTTMASRMVKPKYQGRAIGIVFMGISGSLVLGIPLGILIGNALGWRQVFVMIAILTAIIMITVWFT 177
Cdd:cd17391 307 TGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIF 379
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