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Conserved domains on  [gi|515137053|ref|WP_016765828|]
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MULTISPECIES: carboxymuconolactone decarboxylase family protein [Bacillaceae]

Protein Classification

carboxymuconolactone decarboxylase family protein( domain architecture ID 10001777)

carboxymuconolactone decarboxylase (CMD) family protein similar to alkyl hydroperoxide reductase AhpD, which is required for the reduction of the AhpC active site cysteine residues to regenerate its enzyme activity; carboxymuconolactone d

CATH:  1.20.1290.10
Gene Ontology:  GO:0051920
PubMed:  9495744
SCOP:  4000771

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 10-116 2.93e-27

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


:

Pssm-ID: 440364  Cd Length: 114  Bit Score: 96.94  E-value: 2.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515137053  10 EQALHDYKMGVGKFSEKLPEVTKTFNAFTEACFGE----GSLSKKEKQLIALGISVVAQDEYCMIYHTKGCIDQGATEQE 85
Cdd:COG0599    1 EEVLKEVEEYVPRALEALAEFAPEFAEAFEALFGDvwarGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREE 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 515137053  86 ILEACGVSAAFGGGAAMSQSVTLVQECVSEL 116
Cdd:COG0599   81 IAEALLVAAVYAGFPAALNALRAALEVLEEL 111
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 10-116 2.93e-27

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 96.94  E-value: 2.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515137053  10 EQALHDYKMGVGKFSEKLPEVTKTFNAFTEACFGE----GSLSKKEKQLIALGISVVAQDEYCMIYHTKGCIDQGATEQE 85
Cdd:COG0599    1 EEVLKEVEEYVPRALEALAEFAPEFAEAFEALFGDvwarGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREE 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 515137053  86 ILEACGVSAAFGGGAAMSQSVTLVQECVSEL 116
Cdd:COG0599   81 IAEALLVAAVYAGFPAALNALRAALEVLEEL 111
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 28-111 3.05e-22

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 83.13  E-value: 3.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515137053   28 PEVTKTFNAFTEACFGEGSLSKKEKQLIALGISVVAQDEYCMIYHTKGCIDQGATEQEILEACGVSAAFGGGAAMSQSVT 107
Cdd:pfam02627   1 PELLAALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ....
gi 515137053  108 LVQE 111
Cdd:pfam02627  81 AAEE 84
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 45-89 1.22e-05

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 39.66  E-value: 1.22e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 515137053   45 GSLSKKEKQLIALGISVVAQDEYCMIYHTKGCIDQGATEQEILEA 89
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEA 45
 
Name Accession Description Interval E-value
YurZ COG0599
Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone ...
 10-116 2.93e-27

Uncharacterized conserved protein YurZ, alkylhydroperoxidase/carboxymuconolactone decarboxylase family [General function prediction only];


Pssm-ID: 440364  Cd Length: 114  Bit Score: 96.94  E-value: 2.93e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515137053  10 EQALHDYKMGVGKFSEKLPEVTKTFNAFTEACFGE----GSLSKKEKQLIALGISVVAQDEYCMIYHTKGCIDQGATEQE 85
Cdd:COG0599    1 EEVLKEVEEYVPRALEALAEFAPEFAEAFEALFGDvwarGALDPKTRELITLAALAALGCEPCLKAHVRAALNAGATREE 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 515137053  86 ILEACGVSAAFGGGAAMSQSVTLVQECVSEL 116
Cdd:COG0599   81 IAEALLVAAVYAGFPAALNALRAALEVLEEL 111
CMD pfam02627
Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1. ...
 28-111 3.05e-22

Carboxymuconolactone decarboxylase family; Carboxymuconolactone decarboxylase (CMD) EC:4.1.1.44 is involved in protocatechuate catabolism. In some bacteria a gene fusion event leads to expression of CMD with a hydrolase involved in the same pathway. In these bifunctional proteins CMD represents the C-terminal domain, pfam00561 represents the N-terminal domain.


Pssm-ID: 460628 [Multi-domain]  Cd Length: 84  Bit Score: 83.13  E-value: 3.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515137053   28 PEVTKTFNAFTEACFGEGSLSKKEKQLIALGISVVAQDEYCMIYHTKGCIDQGATEQEILEACGVSAAFGGGAAMSQSVT 107
Cdd:pfam02627   1 PELLAALTALAFGLLWDGGLDPKTRELIALAVSAANGCAYCLDAHTRAALKAGVTEEEIAEVLAWAAAYAGGPAARAALA 80


                  ....
gi 515137053  108 LVQE 111
Cdd:pfam02627  81 AAEE 84
YciW COG2128
Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and ...
 28-86 2.62e-09

Alkylhydroperoxidase family enzyme, contains CxxC motif [Inorganic ion transport and metabolism];


Pssm-ID: 441731 [Multi-domain]  Cd Length: 142  Bit Score: 51.42  E-value: 2.62e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515137053  28 PEVTKTFNAFTEACFGEGSLSKKEKQLIALGISVVAQDEYCMIYHTKGCIDQGATEQEI 86
Cdd:COG2128    3 PELLKAFLALSGALMAKGGLSPRERELVALRVSQINGCAYCLDAHTAIARKAGLDEERI 61
ahpD_dom TIGR00778
alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region ...
 45-89 1.22e-05

alkylhydroperoxidase AhpD family core domain; This model represents a 51-residue core region of homology among a family of mostly uncharacterized proteins of 110 to 227 amino acids. Most members of this family contain the motif EXXXXXX[SA]XXXXXC[VIL]XCXXXH. Members of the family include the alkylhydroperoxidase AhpD of Mycobacterium tuberculosis, a macrophage infectivity potentiator peptide of Legionella pneumophila, and an uncharacterized peptide in the tetrachloroethene reductive dehalogenase operon of Dehalospirillum multivorans. We suggest that many peptides containing this domain may have alkylhydroperoxidase or related antioxidant activity. [Unknown function, General]


Pssm-ID: 273266 [Multi-domain]  Cd Length: 50  Bit Score: 39.66  E-value: 1.22e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 515137053   45 GSLSKKEKQLIALGISVVAQDEYCMIYHTKGCIDQGATEQEILEA 89
Cdd:TIGR00778   1 GALDAATKELIAIAVSQINGCGYCLDAHTKLARKAGVTREELAEA 45
peroxid_rel TIGR01926
uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino ...
 25-72 7.60e-04

uncharacterized peroxidase-related enzyme; This protein family with length of about 200 amino acids. One member, from Myxococcus xanthus, is a selenoprotein, with an otherwise conserved Cys replaced by Sec. This family is drawn narrowly enough to suggest that These proteins contain a domain described by TIGR00778, with a CxxCxxxHxxxxxxxG motif. Some members of that family are known to act as peroxidases or correlate with resistance to oxidative stress.


Pssm-ID: 130981 [Multi-domain]  Cd Length: 177  Bit Score: 37.00  E-value: 7.60e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 515137053   25 EKLPEVTKTFNAFTeacFGEGSLSKKEKQLIALGISVVAQDEYCMIYH 72
Cdd:TIGR01926  41 EALRARTAYFNDLM---LGEGGLSRAERELIAVVVSRANGCVYCAAVH 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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