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Conserved domains on  [gi|515496840|ref|WP_016930094|]
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MULTISPECIES: DUF29 domain-containing protein [Serratia]

Protein Classification

DUF29 domain-containing protein( domain architecture ID 10484212)

uncharacterized DUF29 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF29 pfam01724
Domain of unknown function DUF29; This family consists of various hypothetical proteins from ...
 6-142 2.25e-57

Domain of unknown function DUF29; This family consists of various hypothetical proteins from cyanobacteria, none of which are functionally described. The aligned region is approximately 120-140 amino acids long corresponding to almost the entire length of the proteins in the family. Swiss:Q2RPE2, PDB:3fcn, is a small protein that has a novel all-alpha fold. The N-terminal helical hairpin is likely to function as a dimerization module. This protein is a member of PFam family PF01724. The function of this protein is unknown. One protein sequence contains a fusion of this protein and a DnaB domain, suggesting a possible role in DNA helicase activity (hypothetical). Dali hits have low Z and high rmsd, suggesting probably only topological similarities (not functional relevance) (details derived from TOPSAN). The family has several highly conserved sequence motifs, including YD/ExD, DxxNVxEEIE, and CPY/F/W, as well as conserved tryptophans.


:

Pssm-ID: 426397  Cd Length: 138  Bit Score: 174.93  E-value: 2.25e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515496840    6 YETDVVAWANEQAALLRSGKLSEIDIEKIAEEIEDVGKSEQRELASRMTVLIAHLLKWKYQPARRGTSWERTIKAQRKEV 85
Cdd:pfam01724   2 YEQDFYLWLEETAELLRERQFDELDWENLIEEIEDLGRSEKRELESRLRVLLEHLLKWQYQPERRSRSWRATIREFRRQI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 515496840   86 LYSLKESPSLKGKLsdADWLDVVWSKAVALATAETGLD--VYPENGIWETQQILSQTFY 142
Cdd:pfam01724  82 EDLLEDSPSLKNYL--EEILDEAYQDARKLASKETGLPedTFPEECPYTLEQILDEDFL 138
 
Name Accession Description Interval E-value
DUF29 pfam01724
Domain of unknown function DUF29; This family consists of various hypothetical proteins from ...
 6-142 2.25e-57

Domain of unknown function DUF29; This family consists of various hypothetical proteins from cyanobacteria, none of which are functionally described. The aligned region is approximately 120-140 amino acids long corresponding to almost the entire length of the proteins in the family. Swiss:Q2RPE2, PDB:3fcn, is a small protein that has a novel all-alpha fold. The N-terminal helical hairpin is likely to function as a dimerization module. This protein is a member of PFam family PF01724. The function of this protein is unknown. One protein sequence contains a fusion of this protein and a DnaB domain, suggesting a possible role in DNA helicase activity (hypothetical). Dali hits have low Z and high rmsd, suggesting probably only topological similarities (not functional relevance) (details derived from TOPSAN). The family has several highly conserved sequence motifs, including YD/ExD, DxxNVxEEIE, and CPY/F/W, as well as conserved tryptophans.


Pssm-ID: 426397  Cd Length: 138  Bit Score: 174.93  E-value: 2.25e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515496840    6 YETDVVAWANEQAALLRSGKLSEIDIEKIAEEIEDVGKSEQRELASRMTVLIAHLLKWKYQPARRGTSWERTIKAQRKEV 85
Cdd:pfam01724   2 YEQDFYLWLEETAELLRERQFDELDWENLIEEIEDLGRSEKRELESRLRVLLEHLLKWQYQPERRSRSWRATIREFRRQI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 515496840   86 LYSLKESPSLKGKLsdADWLDVVWSKAVALATAETGLD--VYPENGIWETQQILSQTFY 142
Cdd:pfam01724  82 EDLLEDSPSLKNYL--EEILDEAYQDARKLASKETGLPedTFPEECPYTLEQILDEDFL 138
 
Name Accession Description Interval E-value
DUF29 pfam01724
Domain of unknown function DUF29; This family consists of various hypothetical proteins from ...
 6-142 2.25e-57

Domain of unknown function DUF29; This family consists of various hypothetical proteins from cyanobacteria, none of which are functionally described. The aligned region is approximately 120-140 amino acids long corresponding to almost the entire length of the proteins in the family. Swiss:Q2RPE2, PDB:3fcn, is a small protein that has a novel all-alpha fold. The N-terminal helical hairpin is likely to function as a dimerization module. This protein is a member of PFam family PF01724. The function of this protein is unknown. One protein sequence contains a fusion of this protein and a DnaB domain, suggesting a possible role in DNA helicase activity (hypothetical). Dali hits have low Z and high rmsd, suggesting probably only topological similarities (not functional relevance) (details derived from TOPSAN). The family has several highly conserved sequence motifs, including YD/ExD, DxxNVxEEIE, and CPY/F/W, as well as conserved tryptophans.


Pssm-ID: 426397  Cd Length: 138  Bit Score: 174.93  E-value: 2.25e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515496840    6 YETDVVAWANEQAALLRSGKLSEIDIEKIAEEIEDVGKSEQRELASRMTVLIAHLLKWKYQPARRGTSWERTIKAQRKEV 85
Cdd:pfam01724   2 YEQDFYLWLEETAELLRERQFDELDWENLIEEIEDLGRSEKRELESRLRVLLEHLLKWQYQPERRSRSWRATIREFRRQI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 515496840   86 LYSLKESPSLKGKLsdADWLDVVWSKAVALATAETGLD--VYPENGIWETQQILSQTFY 142
Cdd:pfam01724  82 EDLLEDSPSLKNYL--EEILDEAYQDARKLASKETGLPedTFPEECPYTLEQILDEDFL 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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