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Conserved domains on  [gi|515512950|ref|WP_016946204|]
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MULTISPECIES: phosphatase PAP2 family protein [Klebsiella]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 256)

type 2 phosphatidic acid phosphatase (PAP2) family protein may be a histidine phosphatase or a vanadium haloperoxidase, and is predicted to be a transmembrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like super family cl00474
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 20-143 1.06e-12

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


The actual alignment was detected with superfamily member smart00014:

Pssm-ID: 469784 [Multi-domain]  Cd Length: 116  Bit Score: 61.98  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515512950    20 AVLFIVLFLRKDSkqLAWHWALLFGITgaiVCASKLAFMGWGIGIRELDFTGFSGHTALSSAFWPILLWLLCARATPALr 99
Cdd:smart00014   1 ALLAVVSQLFNGV--IKNYFGRPRPFF---LSIGDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKL- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 515512950   100 ftAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFL 143
Cdd:smart00014  75 --LIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
 
Name Accession Description Interval E-value
acidPPc smart00014
Acid phosphatase homologues;
20-143 1.06e-12

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 61.98  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515512950    20 AVLFIVLFLRKDSkqLAWHWALLFGITgaiVCASKLAFMGWGIGIRELDFTGFSGHTALSSAFWPILLWLLCARATPALr 99
Cdd:smart00014   1 ALLAVVSQLFNGV--IKNYFGRPRPFF---LSIGDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKL- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 515512950   100 ftAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFL 143
Cdd:smart00014  75 --LIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 3-148 3.35e-12

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 62.24  E-value: 3.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515512950   3 WQVVTFFGDSTVLLPSAAVLFIVLFLRKDsKQLAWHWALLFGITGAIVCASKLAFMGWGIGIRELDF-TGF---SGHTAL 78
Cdd:cd03392   32 MTAITFLGSPAVLLIIVLLLALLLLLKRR-RRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLVPeGGYsfpSGHAMG 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515512950  79 SSAFWPILLWLLCARATP-ALRFTAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFLLLQSR 148
Cdd:cd03392  111 ATVLYGFLAYLLARRLPRrRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGLAWLALLILLYRR 181
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 73-148 1.36e-05

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 43.18  E-value: 1.36e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515512950   73 SGHTALSSAFWpILLWLLCARATPALRFTAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFLLLQSR 148
Cdd:pfam01569  50 SGHSATAFALA-LLLALLLRRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 1-148 4.85e-05

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 42.33  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515512950   1 MNWQVVTFFGDSTVLLPSAAVLFIVLFLRKDSKQLAWHWALLFGITGAIVCASKLA--------FMGWGIGIRELDFTGF 72
Cdd:COG0671   38 LLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKylfgrprpFVVPDLELLLGTAGGY 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515512950  73 ---SGHTALSSAFWPILLWLLcaratpaLRFTAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFLLLQSR 148
Cdd:COG0671  118 sfpSGHAAAAFALALVLALLL-------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALLRR 189
 
Name Accession Description Interval E-value
acidPPc smart00014
Acid phosphatase homologues;
20-143 1.06e-12

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 61.98  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515512950    20 AVLFIVLFLRKDSkqLAWHWALLFGITgaiVCASKLAFMGWGIGIRELDFTGFSGHTALSSAFWPILLWLLCARATPALr 99
Cdd:smart00014   1 ALLAVVSQLFNGV--IKNYFGRPRPFF---LSIGDACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKL- 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 515512950   100 ftAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFL 143
Cdd:smart00014  75 --LIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 3-148 3.35e-12

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 62.24  E-value: 3.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515512950   3 WQVVTFFGDSTVLLPSAAVLFIVLFLRKDsKQLAWHWALLFGITGAIVCASKLAFMGWGIGIRELDF-TGF---SGHTAL 78
Cdd:cd03392   32 MTAITFLGSPAVLLIIVLLLALLLLLKRR-RRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLVPeGGYsfpSGHAMG 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515512950  79 SSAFWPILLWLLCARATP-ALRFTAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFLLLQSR 148
Cdd:cd03392  111 ATVLYGFLAYLLARRLPRrRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGLAWLALLILLYRR 181
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 73-143 1.41e-06

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 45.53  E-value: 1.41e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515512950  73 SGHTALSSAFWPILLWLLCARAtpaLRFTAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFL 143
Cdd:cd01610   55 SGHAAFAFALALFLALLLPRRL---LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 73-148 1.36e-05

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 43.18  E-value: 1.36e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515512950   73 SGHTALSSAFWpILLWLLCARATPALRFTAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFLLLQSR 148
Cdd:pfam01569  50 SGHSATAFALA-LLLALLLRRLRKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVPK 124
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 1-148 4.85e-05

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 42.33  E-value: 4.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515512950   1 MNWQVVTFFGDSTVLLPSAAVLFIVLFLRKDSKQLAWHWALLFGITGAIVCASKLA--------FMGWGIGIRELDFTGF 72
Cdd:COG0671   38 LLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKylfgrprpFVVPDLELLLGTAGGY 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515512950  73 ---SGHTALSSAFWPILLWLLcaratpaLRFTAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFLLLQSR 148
Cdd:COG0671  118 sfpSGHAAAAFALALVLALLL-------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALLRR 189
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 73-143 7.03e-04

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 38.38  E-value: 7.03e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515512950  73 SGHTALS--SAFWPILLW--LLCARATPALRFTAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLGaAGSAIFL 143
Cdd:cd03384   76 SGHASLSmyAAVFLALYLqaRLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLG-SVIALFL 149
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 73-135 3.74e-03

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 36.81  E-value: 3.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515512950  73 SGHTALS-SAFWPILLWLLC-----ARATPALRFTAVIVGYALAGLVGYSRLMVHAHSTSEVIAGLLLG 135
Cdd:cd03390  114 SGHSSFAfAGLGFLSLYLAGklhifDPRGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIG 182
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 72-145 9.93e-03

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 35.70  E-value: 9.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515512950  72 FSGHTALSSAFwPILLWLLcaraTPALRFTAVIVGYALagLVGYSRLMVHAHSTSEVIAGLLLGAAGSAIFLLL 145
Cdd:cd03395  107 ASSHAANSFAL-ALFIWLF----FRRGLFSPVLLLWAL--LVGYSRVYVGVHYPGDVIAGALIGIISGLLFYLL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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