|
Name |
Accession |
Description |
Interval |
E-value |
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
19-362 |
0e+00 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 595.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 19 MDCFFAAVEMRDFPEYRNRPLAVGGSETQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKEVSAQIRA 98
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGSPGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 99 IFARYTHIIEPLSLDEAYLDVTDSSSCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKPNGQYVIPPNQ 178
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLCIGSATLIAQEIRQDIFEELGLTASAGVAPNKFLAKIASDWNKPNGLFVITPEE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 179 VQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHGRLGASLWKRCHGVDNRSVQVSRERKSVGVERT 258
Cdd:PRK02406 161 VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFGKFGRRLYERARGIDERPVKPDRERKSVGVERT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 259 FTKNIETLEQCWEVIEqRLYPELQRRLDKVGGEhvRPITKQGIKVKFADFQLTTIETGSNKLNLAAFYPLLEEVLLRQQ- 337
Cdd:PRK02406 241 FAEDLYDLEACLAELP-RLAEKLERRLERAKPD--KRIKTVGVKLKFADFQQTTKEHTADPLDKADLIELLAQALLRRLg 317
|
330 340
....*....|....*....|....*
gi 515598571 338 GREIRLLGLSVMLQPEAQAKQLSLL 362
Cdd:PRK02406 318 GRGVRLLGVGVTLLEPQLERQLLLD 342
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
15-348 |
6.49e-164 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 461.61 E-value: 6.49e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 15 IHIDMDCFFAAVEMRDFPEYRNRPLAVGGSEtQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKEVSA 94
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSS-DRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 95 QIRAIFARYTHIIEPLSLDEAYLDVTDSSSCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKPNGQYVI 174
Cdd:cd03586 80 QIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSATEIAKEIRARIREETGLTASAGIAPNKFLAKIASDLNKPNGLTVI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 175 PPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHGRLGASLWKRCHGVDNRSVQVSRERKSVG 254
Cdd:cd03586 160 PPEDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRERKSIG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 255 VERTFTKNIETLEQCWEVIEqRLYPELQRRLDKVGgehvRPITKQGIKVKFADFQLTTIETGSNK--LNLAAFYPLLEEV 332
Cdd:cd03586 240 VERTFSEDLTDPEELLEELL-ELAEELAERLRKRG----LKGRTVTVKLKYADFSTRTRSRTLPEptDDAEDIYELALEL 314
|
330
....*....|....*..
gi 515598571 333 LLRQ-QGREIRLLGLSV 348
Cdd:cd03586 315 LEELlDGRPIRLLGVRL 331
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
12-349 |
1.12e-139 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 400.29 E-value: 1.12e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 12 RKIIHIDMDCFFAAVEMRDFPEYRNRPLAVGGSEtQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKE 91
Cdd:COG0389 1 RRILHVDMDAFYASVEQRDRPELRGKPVAVGGDN-NRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 92 VSAQIRAIFARYTHIIEPLSLDEAYLDVTDSSSCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKPNGQ 171
Cdd:COG0389 80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 172 YVIPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANyRDLLVRH-GRLGASLWKRCHGVDNRSVQVSRER 250
Cdd:COG0389 160 TVIPPGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALP-RAELRRRfGKVGERLYRLARGIDPRPVEPRRPR 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 251 KSVGVERTFTKNIETLEQCWEVIEqRLYPELQRRLDKVGgehvRPITKQGIKVKFADFQLTTIE-TGSNKLNLAA-FYPL 328
Cdd:COG0389 239 KSIGVERTFGEDLTDLEELEAALR-RLAERLAERLRRQG----LGARTVTVKLRTSDFRTTTRSrTLPEPTDDTAeLLRA 313
|
330 340
....*....|....*....|...
gi 515598571 329 LEEVL--LRQQGREIRLLGLSVM 349
Cdd:COG0389 314 ARELLerIYRPGRPVRLLGVRLS 336
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
12-362 |
1.06e-98 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 296.24 E-value: 1.06e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 12 RKIIHIDMDCFFAAVEMRDFPEYRNRPLAVGGSeTQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKE 91
Cdd:PRK14133 3 RVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGI-SERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYKE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 92 VSAQIRAIFARYTHIIEPLSLDEAYLDVTDsssCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKPNGQ 171
Cdd:PRK14133 82 VSKNIFKILYEVTPIVEPVSIDEAYLDITN---IKEEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLASDWNKPDGI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 172 YVIPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRK---ANYRDLLvrhGRLGASLWKRCHGVDNRSVQVSR 248
Cdd:PRK14133 159 KIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlsrEFLIEYF---GKFGVEIYERIRGIDYREVEVSR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 249 ERKSVGVERTF---TKNIETLEQCWEVIEQRLYPELQRRldKVGGehvRPITkqgIKVKFADFQLTT--------IETGS 317
Cdd:PRK14133 236 ERKSIGKETTLkkdTKDKEELKKYLKDFSNIISEELKKR--NLYG---KTVT---VKIKTSDFQTHTksktlndyIRDKE 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 515598571 318 NKLNLAafYPLLEEVLLRQqgrEIRLLGLSVMLQPEAQAKQLSLL 362
Cdd:PRK14133 308 EIYNVA--CEILEHINIKE---PIRLIGLSVSNLSENKIEQLSFL 347
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
14-363 |
3.13e-88 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 271.81 E-value: 3.13e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 14 IIHIDMDCFFAAVEMRDFPEYRNRPLAVGGSetQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKEVS 93
Cdd:PRK02794 38 IAHIDCDAFYASVEKRDNPELRDKPVIIGGG--KRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 94 AQIRAIFARYTHIIEPLSLDEAYLDVTDSSSCNGS--ATLIAQSIRRdIESELNLTASAGIAPIKFLAKVASDLNKPNGQ 171
Cdd:PRK02794 116 REVRAMMQALTPLVEPLSIDEAFLDLSGTERLHGAppAVVLARFARR-VEREIGITVSVGLSYNKFLAKIASDLDKPRGF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 172 YVIPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHGRLGASLWKRCHGVDNRSVQVSRERK 251
Cdd:PRK02794 195 SVIGRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFGSMGLRLWRLARGIDDRKVSPDREAK 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 252 SVGVERTFTKNI---ETLEQcwevIEQRLYPELQRRLdKVGGEHVRPITkqgIKVKFADF-QLTTIETGSNKLNLAA-FY 326
Cdd:PRK02794 275 SVSAETTFETDLsdfEDLEP----ILWRLSEKVSRRL-KAAGLAGRTVT---LKLKTADFrLRTRRRTLEDPTQLADrIF 346
|
330 340 350
....*....|....*....|....*....|....*....
gi 515598571 327 PLLEEVLLRQ-QGREIRLLGLSVM-LQPEAQAKQLSLLD 363
Cdd:PRK02794 347 RTARELLEKEtDGTAFRLIGIGVSdLSPADEADPPDLLD 385
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
11-348 |
8.58e-86 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 266.80 E-value: 8.58e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 11 QRKIIHIDMDCFFAAVEMRDFPEYRNRPLAVGGSeTQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHL-LVVPGRMQVY 89
Cdd:PRK03348 4 QRWVLHLDMDAFFASVEQLTRPTLRGRPVLVGGL-GGRGVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 90 KEVSAQIRAIFARYTHIIEPLSLDEAYLD---VTDSSScnGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLN 166
Cdd:PRK03348 83 RAASRRVFDTLRELSPVVEQLSFDEAFVEpaeLAGASA--EEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 167 KPNGQYVIPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHGR-LGASLWKRCHGVDNRSVQ 245
Cdd:PRK03348 161 KPDGIRVVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGAtVGPALHRLARGIDDRPVA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 246 VSRERKSVGVERTFTKNIETLEQCWEVIEqRLYPELQRRLDKvGGEHVRPITkqgIKVKFADFqltTIETGSNKL----- 320
Cdd:PRK03348 241 ERAEAKQISAESTFAVDLTTRAQLREAIE-RIAEHAHRRLLK-DGRGARTVT---VKLRKSDF---STLTRSATLpyatd 312
|
330 340 350
....*....|....*....|....*....|
gi 515598571 321 NLAAFYPLLEEVLLR--QQGrEIRLLGLSV 348
Cdd:PRK03348 313 DAAVLAATARRLLLDpdEIG-PIRLVGVGF 341
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
10-289 |
4.87e-76 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 240.29 E-value: 4.87e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 10 PQRKIIHIDMDCFFAAVEMRDFPEYRNRPLAVGGSETQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVY 89
Cdd:cd01701 45 LQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVCHGKGPNSEIASCNYEARSYGIKNGMWVGQAKKLCPQLVTLPYDFEAY 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 90 KEVSAQIRAIFARYTHIIEPLSLDEAYLDVTD-SSSCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKP 168
Cdd:cd01701 125 EEVSLTFYEILASYTDNIEAVSCDEALIDITSlLEETYELPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKP 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 169 NGQYVIPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYL--GEDVRKANYRDLLVRHG-RLGASLWKRCHGVDNRSVQ 245
Cdd:cd01701 205 DGQYHLSAEKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTcgGLELRSKTKEKLQKVLGpKTGEKLYDYCRGIDDRPVT 284
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 515598571 246 VSRERKSVGVERTFTKNIETLEQCWEVIeQRLYPELQRRLDKVG 289
Cdd:cd01701 285 GEKERKSVSAEINYGIRFTNVDDVEQFL-QRLSEELSKRLEESN 327
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
12-365 |
2.50e-75 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 238.39 E-value: 2.50e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 12 RKIIHIDMDCFFAAVEMRDFPEYRNRPLAVGGSETQR-GVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYK 90
Cdd:PRK01810 5 RVIFHVDMNSFFASVEIAYDPSLQGKPLAVAGNEKERkGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 91 EVSAQIRAIFARYTHIIEPLSLDEAYLDVTDSSScNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKPNG 170
Cdd:PRK01810 85 EASRQMFQILSEFTPLVQPVSIDEGYLDITDCYA-LGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 171 QYVIPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHGRLGASLWKRCHGVDNRSVQVSR-- 248
Cdd:PRK01810 164 ITVLRKRDVPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIDDRPVDPEAiy 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 249 ERKSVGVERTFTKNIETLEQCWEVIeQRLYPELQRRLDKvggEHVRPITKQgIKVKFADFQltTIeTGSNKLNLAAFYP- 327
Cdd:PRK01810 244 QFKSVGNSTTLSHDMDEEKELLDVL-RRLSKSVSKRLQK---KTVVSYNVQ-IMIRYHDRR--TI-TRSKTLKNPIWEKr 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 515598571 328 -LLEEV--LLRQQ--GREIRLLGLSV--MLQPEAQAKQLSLLDNE 365
Cdd:PRK01810 316 dIFQAAsrLFKQHwnGDPVRLLGVTAtdLEWKTEAVKQLDLFSFE 360
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
14-361 |
3.22e-68 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 219.86 E-value: 3.22e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 14 IIHIDMDCFFAAVEMRDFPEYRNRPLAVGGsetqrGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKEVS 93
Cdd:PRK03858 6 ILHADLDSFYASVEQRDDPALRGRPVIVGG-----GVVLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 94 AQIRAIFARYTHIIEPLSLDEAYLDVTDSSSCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKPNGQYV 173
Cdd:PRK03858 81 KAVFEVFRDTTPLVEGLSIDEAFLDVGGLRRISGTPVQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 174 IPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHGR-LGASLWKRCHGVDNRSVQVSRERKS 252
Cdd:PRK03858 161 VPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGPaAGRHLHALAHNRDPRRVETGRRRRS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 253 VGVERTFTKNIETLEQCWEVIEQrLYPELQRRLdKVGGEHVRPITkqgIKVKFADFQLTT------IETGSNKLNLAAFY 326
Cdd:PRK03858 241 VGAQRALGRGPNSPAEVDAVVVA-LVDRVARRM-RAAGRTGRTVV---LRLRFDDFTRATrshtlpRPTASTATLLAAAR 315
|
330 340 350
....*....|....*....|....*....|....*
gi 515598571 327 PLLEEVLLRQQGREIRLLGLSVMLQPEAQAKQLSL 361
Cdd:PRK03858 316 DLVAAAAPLIAERGLTLVGFAVSNLDDDGAQQLEL 350
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
16-347 |
1.49e-67 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 216.46 E-value: 1.49e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 16 HIDMDCFFAAVEMRDFPEYRNRPLAVGGSETQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKEVSAQ 95
Cdd:cd00424 2 HIDFDNFFASVEQLARPELKGRPVVVVPFNSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 96 IRAIFARYTHIIEPLSLDEAYLDVTDSSSCNGSATLIAQSIRRDIESELN-LTASAGIAPIKFLAKVASDLNKPNGQYVI 174
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGSARLLGLGSEVALRIKRHIAEQLGgITASIGIASNKLLAKLAAKYAKPDGLTIL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 175 PPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLL-VRHGRLGASLWKRCHGVDNRSVQVSRERKSV 253
Cdd:cd00424 162 DPEDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLaLWGGVSGERLWYALRGIDDEPLSPPRPRKSF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 254 GVERTFTKNIETLEQCWEVIEqRLYPELQRRLDKVGGE----HVRPITKQGIKVKFADF---QLTTIETGSNKLNLAAFY 326
Cdd:cd00424 242 SHERVLPRDSRNAEDARPLLR-LLLEKLARRLRRDGRGatrlRLWLRTVDGRWSGHADIpsrSAPRPISTEDGELLHALD 320
|
330 340
....*....|....*....|.
gi 515598571 327 PLLEEVLLRQQGREIRLLGLS 347
Cdd:cd00424 321 KLWRALLDDKGPRRLRRLGVR 341
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
17-164 |
5.46e-64 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 200.49 E-value: 5.46e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 17 IDMDCFFAAVEMRDFPEYRNRPLAVGGSETqRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKEVSAQI 96
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGNG-RGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515598571 97 RAIFARY-THIIEPLSLDEAYLDVTDSSSCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASD 164
Cdd:pfam00817 80 FEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEEALAKRLRREIAEETGLTCSIGIAPNKLLAKLASD 148
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
11-364 |
4.03e-59 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 196.38 E-value: 4.03e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 11 QRKIIHIDMDCFFAAVEMRDFPEYRNRPLAVGGSETQRG--VLSTCnYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQV 88
Cdd:PRK03103 2 ERVILLVDMQSFYASVEKAANPELKGRPVIVSGDPERRSgvVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 89 YKEVSAQIRAIFARYTHIIEPLSLDEAYLDVTDSSSCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDL--- 165
Cdd:PRK03103 81 YIDVSLQITRILEDFTDLVEPFSIDEQFLDVTGSQKLFGSPLEIAQKIQQRIMRETGVYARVGIGPNKLLAKMACDNfak 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 166 NKPNGQYVIPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLY-LGEdvrKANY--RDLLVRHGRLGASLWKRCHGVDNR 242
Cdd:PRK03103 161 KNPDGLFTLDKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRtIGQ---LANTplERLKKRWGINGEVLWRTANGIDYS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 243 SVQVSR--ERKSVGVERTFTKNIETLEQCwEVIEQRLYPELQR--RLDKVGGEHVrpitkqGIKVKFADFQLTTIETGSN 318
Cdd:PRK03103 238 PVTPHSldRQKAIGHQMTLPRDYRGFEEI-KVVLLELCEEVCRraRAKGYMGRTV------SVSLRGADFDWPTGFSRQM 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 515598571 319 KL----NLAA-FYPLLEEVLLRQ-QGREIRLLGLSVM-LQPeAQAKQLSLLDN 364
Cdd:PRK03103 311 TLpeptNLAMeVYEAACKLFHRHwDGKPVRRVGVTLSnLVS-DDVWQLSLFGD 362
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
14-286 |
1.61e-50 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 172.28 E-value: 1.61e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 14 IIHIDMDCFFAAVEMRDFPEYRNRPLAV---GGSETQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYK 90
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVcvySGRFEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 91 EVSAQIRAIFARYTHIIEPLSLDEAYLDVTDSSSCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKPNG 170
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 171 QYVIPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHGRLGAS-LWKRCHGVDNRSVQvSRE 249
Cdd:PRK01216 163 IKVIDDEEVKRFINELDIADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGEAKAKyLFSLARNEYNEPVR-ARV 241
|
250 260 270
....*....|....*....|....*....|....*..
gi 515598571 250 RKSVGVERTFTKNIETLEqcwevieqRLYPELQRRLD 286
Cdd:PRK01216 242 RKSIGRYVTLPRNTRDLE--------EIKPYLKRAIE 270
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
16-287 |
2.97e-48 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 166.72 E-value: 2.97e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 16 HIDMDCFFAAVEMRDFPEYRNRPLAVggseTQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVV------------- 82
Cdd:cd01702 2 HIDMDAFFAQVEQVRLGLLRNDPVAV----VQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILAhvatykkgedead 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 83 ------PGRMQV----YKEVSAQIRAIFARYTHIIEPLSLDEAYLDVtdssscnGSAtlIAQSIRRDIESELNLTASAGI 152
Cdd:cd01702 78 yhenpsPARHKVsldpYRRASRKILNILKRFGDVVEKASIDEAYLDL-------GSR--IVEEIRQQVYDELGYTCSAGI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 153 APIKFLAKVASDLNKPNGQYVIPPNQVQEFIDSMPLQKIPG----VGKVALQRLhrtGLYLGEDVRKANYRDL-LVRH-- 225
Cdd:cd01702 149 AHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLPITSIRGlggkLGEEIIDLL---GLPTEGDVAGFRSSESdLQEHfg 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515598571 226 GRLGASLWKRCHGVDNRSVQVSRERKSVGVERTFT-KNIETLEQCWEVIEQrLYPELQRRLDK 287
Cdd:cd01702 226 EKLGEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFPgKTALSTEDVQHWLLV-LASELNSRLED 287
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
15-348 |
3.68e-45 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 159.17 E-value: 3.68e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 15 IHIDMDCFFAAVEMRDFPEYRNRPLAVggseTQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGR-MQVYKEVS 93
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGI----QQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEdLTPFRDMS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 94 AQIRAIFARYT--HIIEPLSLDEAYLDVTDSSSCNGSAtlIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKPNGQ 171
Cdd:cd01703 77 KKVYRLLRSYSwnDRVERLGFDENFMDVTEMRLLVASH--IAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 172 YVIPP---NQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGED--------------VRKANYRDLLVRH-GR-LGASL 232
Cdd:cd01703 155 TTLLPpscADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDlqefsnrnrqtvgaAPSLLELLLMVKEfGEgIGQRI 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 233 WKRCHGVDNRSVQVSRER-KSVGVERTFTK-NIETLEQCWEVIEQRLYPELQRRLDKVGGEHV----RPITKQGIKVKFA 306
Cdd:cd01703 235 WKLLFGRDTSPVKPASDFpQQISIEDSYKKcSLEEIREARNKIEELLASLLERMKQDLQEVKAgdgrRPHTLRLTLRRYT 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515598571 307 DFQLT-------------TIETGSNKLNLAAfyPLLEEVLLR----------QQGREIRLLGLSV 348
Cdd:cd01703 315 STKKHynreskqapipshVFQKLTGGNEIAA--RPIEKILMRlfrelvppknVKGFNLTLLNVCF 377
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
15-283 |
2.31e-43 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 158.26 E-value: 2.31e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 15 IHIDMDCFFAAVEMRDFPEYRNRPLAVGgsetQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKEVSA 94
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAIG----TMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILPPDFDAYNEESN 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 95 QIRAIFARYTHIIEPLSLDEAYLDVT---DSSSCNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKPNGQ 171
Cdd:PTZ00205 212 TVRRIVAEYDPNYISFGLDELTLEVSayiERFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINKPNGQ 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 172 YVI---PPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHGR-----LGASL----W-KRCHG 238
Cdd:PTZ00205 292 HDLnlhTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNlfrflLGASIgimqWpDAATA 371
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 515598571 239 VDNRSVQ--VSRERKSVGVERTFT--KNIETLEQCWEVIEQRLYPELQR 283
Cdd:PTZ00205 372 ANTENCEgaTGGQRKAISSERSFTtpRTKEGLQEMVDTVFNGAYEEMRK 420
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
12-353 |
1.86e-42 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 150.94 E-value: 1.86e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 12 RKIIHIDMDCFFAAVEMRDFPEYRNRPLAVGGS---ETQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQV 88
Cdd:PRK03352 5 RWVLHVDLDQFIAAVELLRRPELAGLPVIVGGNgdpTEPRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 89 YKEVSAQIRAIFARYTHIIEPLSLDEAYLDVTdssscNGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNKP 168
Cdd:PRK03352 85 YDAASEEVMATLRDLGVPVEVWGWDEAFLGVD-----TDDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 169 NGQYVIPPNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHG-RLGASLWKRCHGVDNRSVQ-V 246
Cdd:PRK03352 160 AGVFRLTDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpTTGPWLLLLARGGGDTEVSaE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 247 SRERKSVGVERTFTKNIEtleqCWEVIEQRLYPELQRRLDKVGGEHvRPITKQGIKVKFADFqltTIETGSNKLNLAAFY 326
Cdd:PRK03352 240 PWVPRSRSREVTFPQDLT----DRAEVESAVRELARRVLDEVVAEG-RPVTRVAVKVRTATF---YTRTKIRKLPEPTTD 311
|
330 340 350
....*....|....*....|....*....|...
gi 515598571 327 P-LLEEVLLR-----QQGREIRLLGLSVMLQPE 353
Cdd:PRK03352 312 PdVIEAAALDvldrfELDRPVRLLGVRLELAMP 344
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
17-273 |
3.69e-36 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 134.21 E-value: 3.69e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 17 IDMDCFFAAVE--MRdfPEYRNRPLAVGgSETQRGVLSTCNyEARRFGIHSAMPTAQAKKLCP--HLLVVPGRMQVYKEV 92
Cdd:cd01700 3 VDCNSFYASCErvFR--PLLLGRPLVVL-SNNDGCVIARSP-EAKALGIKMGSPYFKVPDLLErhGVAVFSSNYALYGDM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 93 SAQIRAIFARYTHIIEPLSLDEAYLDVTDSSSCnGSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDL----NKP 168
Cdd:cd01700 79 SRRIMSILERFSPDVEVYSIDESFLDLTGSLRF-GDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLakkkNPY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 169 NGQYVIPPNQVQEFI-DSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYRDLLVRHGRLGASLWKRCHGVDNRSVQVS 247
Cdd:cd01700 158 GGVVDLTDEEVRDKLlKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEY 237
|
250 260
....*....|....*....|....*..
gi 515598571 248 RE-RKSVGVERTFTKNIETLEQCWEVI 273
Cdd:cd01700 238 PPpKKSIGSSRSFGRDVTDLDELKQAL 264
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
29-284 |
3.26e-18 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 84.36 E-value: 3.26e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 29 RDFPEYRNRPLAVGgSETQRGVLSTCNYEARRFGIHSAMPTAQAKKLCPHLLVVPGRMQVYKEVSAQIRAIFARYTHIIE 108
Cdd:cd03468 15 RNRPADDEAPLAVV-ERKKAGRILACNAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLVA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 109 PLSLDEAYLDVTDSSSCNGSATLIAQSIRRDIEsELNLTASAGIAPIKFLAKVASDLNKPNGQYVIPPNQVQEFIDSMPL 188
Cdd:cd03468 94 LDGPDGLLLDVTGCLHLFGGEDALAASLRAALA-TLGLSARAGIADTPGAAWLLARAGGGRGVLRREALAAALVLLAPLP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 189 QKIPGVGKVALQRLHRTGL-YLGEDvrKANYRDLLVRhgRLGASL---WKRCHGVDNRSVQVS--RERKSVGVERTFTKN 262
Cdd:cd03468 173 VAALRLPPETVELLARLGLrTLGDL--AALPRAELAR--RFGLALllrLDQAYGRDPEPLLFSppPPAFDFRLELQLEEP 248
|
250 260
....*....|....*....|...
gi 515598571 263 I-ETLEQCWEVIEQRLYPELQRR 284
Cdd:cd03468 249 IaRGLLFPLRRLLEQLCAFLALR 271
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
16-219 |
2.32e-10 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 61.70 E-value: 2.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 16 HIDMDCFFAAVEMRDFPEYRNRPLAVggSETQRGVLSTCNYEARRFGIHSAMPTAQAKKL-CPHLLVV-PGRMQVYKEVS 93
Cdd:PRK03609 4 LCDVNSFYASCETVFRPDLRGKPVVV--LSNNDGCVIARSAEAKALGIKMGDPWFKQKDLfRRCGVVCfSSNYELYADMS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 94 AQIRAIFARYTHIIEPLSLDEAYLDVTDSSSCNgSATLIAQSIRRDIESELNLTASAGIAPIKFLAKVASDLNK---PNG 170
Cdd:PRK03609 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCR-DLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKkwqRQT 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 515598571 171 QYVIP---PNQVQEFIDSMPLQKIPGVGKVALQRLHRTGLYLGEDVRKANYR 219
Cdd:PRK03609 161 GGVVDlsnLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIR 212
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
250-354 |
3.15e-10 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 56.80 E-value: 3.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515598571 250 RKSVGVERTFTKNIETLEQCWEVIEqRLYPELQRRLDKvggEHVRPITKQgIKVKFADFQLTTIE------TGSNKLNLA 323
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALL-ELAEELAERLRR---QGLVARTVT-VKIRYSDFRTITRSvtlpspTDDTDEIYR 75
|
90 100 110
....*....|....*....|....*....|..
gi 515598571 324 AFYPLLEEVllrQQGREIRLLGLSVM-LQPEA 354
Cdd:pfam11799 76 AALRLLRRL---YRGRPVRLLGVSLSnLVPEG 104
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
176-207 |
4.23e-05 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 40.07 E-value: 4.23e-05
10 20 30
....*....|....*....|....*....|..
gi 515598571 176 PNQVQEFIDSMPLQKIPGVGKVALQRLHRTGL 207
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
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