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Conserved domains on  [gi|515625261|ref|WP_017057861|]
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MULTISPECIES: NrfD/PsrC family molybdoenzyme membrane anchor subunit [Vibrio]

Protein Classification

polysulfide reductase NrfD family protein( domain architecture ID 229967)

polysulfide reductase NrfD/PsrC family protein may be a component of polysulfide reductase, an integral membrane protein complex responsible for quinone-coupled reduction of polysulfide

Gene Ontology:  GO:0016020
PubMed:  18536726

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
NrfD super family cl21513
Polysulphide reductase, NrfD; NrfD is an integral transmembrane protein with loops in both the ...
3-350 1.17e-54

Polysulphide reductase, NrfD; NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway.


The actual alignment was detected with superfamily member PRK14992:

Pssm-ID: 451283  Cd Length: 335  Bit Score: 183.09  E-value: 1.17e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261   3 ITEVLVPAQEMAWLPWAVQYFFYIGSAyAAAILFLIALIFKDSTSHQFRSALVLVMAIGGIVGPLALTGDLHQPGRAWHF 82
Cdd:PRK14992   2 IEEVLAHPQDISWLPWAVQYFFFIGIA-ACAALFACYLHWRKKDAATEENRALLIAVTCAITAPLALTADLHQTARVWHF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261  83 YAHITPWSWMWVGSLFLPLFSGLAVAtawVYLRDDIAQLKESENPLLKrlsWLTLgqwqvstklmialaaVTAVSGLSIA 162
Cdd:PRK14992  81 YAWPTPWSWMPWGALFLPLFTGFLAL---WFLAQQIKRLFNKSYNVTK---WLAL---------------ASALCAVGLL 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 163 LYTGAEIAILASRPLWHQPASPLLWFSTAFFAAIGLALLIWALLPSSEPNLKTTDL-SLVqkTITLTGGLAIILTSIWAS 241
Cdd:PRK14992 140 IYTGREVSVVLARPIWFSYAFPVAMFLSALQAFFALMIVAARRDSVRLPKILWGQIwTLA--ALGLVVAMWVSGDTLSGT 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 242 NHGHFNLYENDTWGINLGIMTTSILLCMILVLPLQRlSRSKLGIVCIALATILSAWVVRWVTMMEVQTIPRFDVGPFPYE 321
Cdd:PRK14992 218 AIRQWITVALSAKYYAVGWLALWVFTLLFCSLALRH-PLSQLRRVLLVLSALALCWLMRWTLLIQVQTVPKFNAQFNPYS 296
                        330       340
                 ....*....|....*....|....*....
gi 515625261 322 LPIGSSGLLGIVGMCGLWLALALFASEIV 350
Cdd:PRK14992 297 LPGGTDGWLAILGTFGLWIALLIIIRETL 325
 
Name Accession Description Interval E-value
PRK14992 PRK14992
tetrathionate reductase subunit TtrC;
3-350 1.17e-54

tetrathionate reductase subunit TtrC;


Pssm-ID: 184954  Cd Length: 335  Bit Score: 183.09  E-value: 1.17e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261   3 ITEVLVPAQEMAWLPWAVQYFFYIGSAyAAAILFLIALIFKDSTSHQFRSALVLVMAIGGIVGPLALTGDLHQPGRAWHF 82
Cdd:PRK14992   2 IEEVLAHPQDISWLPWAVQYFFFIGIA-ACAALFACYLHWRKKDAATEENRALLIAVTCAITAPLALTADLHQTARVWHF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261  83 YAHITPWSWMWVGSLFLPLFSGLAVAtawVYLRDDIAQLKESENPLLKrlsWLTLgqwqvstklmialaaVTAVSGLSIA 162
Cdd:PRK14992  81 YAWPTPWSWMPWGALFLPLFTGFLAL---WFLAQQIKRLFNKSYNVTK---WLAL---------------ASALCAVGLL 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 163 LYTGAEIAILASRPLWHQPASPLLWFSTAFFAAIGLALLIWALLPSSEPNLKTTDL-SLVqkTITLTGGLAIILTSIWAS 241
Cdd:PRK14992 140 IYTGREVSVVLARPIWFSYAFPVAMFLSALQAFFALMIVAARRDSVRLPKILWGQIwTLA--ALGLVVAMWVSGDTLSGT 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 242 NHGHFNLYENDTWGINLGIMTTSILLCMILVLPLQRlSRSKLGIVCIALATILSAWVVRWVTMMEVQTIPRFDVGPFPYE 321
Cdd:PRK14992 218 AIRQWITVALSAKYYAVGWLALWVFTLLFCSLALRH-PLSQLRRVLLVLSALALCWLMRWTLLIQVQTVPKFNAQFNPYS 296
                        330       340
                 ....*....|....*....|....*....
gi 515625261 322 LPIGSSGLLGIVGMCGLWLALALFASEIV 350
Cdd:PRK14992 297 LPGGTDGWLAILGTFGLWIALLIIIRETL 325
NrfD COG3301
Nitrite/polysulfide reductase, membrane component NrfD/PsrC [Inorganic ion transport and ...
7-311 6.52e-29

Nitrite/polysulfide reductase, membrane component NrfD/PsrC [Inorganic ion transport and metabolism];


Pssm-ID: 442530  Cd Length: 297  Bit Score: 113.85  E-value: 6.52e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261   7 LVPAQEMAWLPWAVQYFFYIGSAYAAAILFLIALIFKDSTSHQFRSALVLVMAIGGIVGPLALTGDLHQPGRAWHFYAHI 86
Cdd:COG3301    4 YDVFHQLVWGWPIAIYLFLGGLGAGAFLLAALLDLLGRPESRALRRAGALIALVFLAIGLLLLVLDLGRPLRFWKLLLNP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261  87 TPWSWMWVGSLFLPLFSGLAVATAWVYLRDDIAqlkesenpllkrlswltlgqWQVSTKLMIALAAVTAVSGLSIALYTG 166
Cdd:COG3301   84 NPTSWMSWGVWLLSLFGLLALLYAALLLKKELR--------------------LPLLEKLRRALALLGALLALLLAAYTG 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 167 AEIAILASRPLWHQPASPLLWFSTAFFAAIGLALLIWALLPSSEPN----LKTTDLSLVQKTITLTGGLAIILTSIWASN 242
Cdd:COG3301  144 FLLSAAKARPLWNTPLLPVLFLVSALSTGAAALLLLALLFGKEPSEelhlLHRLDVALILLELVLLAAFLVGLHLGGAAA 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515625261 243 HGHFNLYENDTWGIN--LGIMTTSILLCMILVLPLQRLSRSKLGIVCIALATILSAWVVRWVTMMEVQTIP 311
Cdd:COG3301  224 AAAAEALLTGRYAPLfwGGVVGLGLLLPLLLELAALKLKRSKGLLALAALLVLVGGLLLRYLILYAGQLTP 294
NrfD pfam03916
Polysulphide reductase, NrfD; NrfD is an integral transmembrane protein with loops in both the ...
16-311 2.39e-13

Polysulphide reductase, NrfD; NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway.


Pssm-ID: 397824  Cd Length: 313  Bit Score: 70.13  E-value: 2.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261   16 LPWAVqYFFYIGSAYAAAILFLIALIFKDSTS---HQFRSALVLVMAIGGIVGPLALTGDLHQPGRAWHFYAHITPWSWM 92
Cdd:pfam03916  13 LPIAV-YLFLIGISAGALILAILYKRFKKNEGkpfNLIIRTGALLAPLAVLAGLLILIFDLGRPWRFWKLLRYYNFSSIM 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261   93 WVGSLFLPLFSGLAVATAWVYLRDDIAQLKESENPLLKRLswltlgqWQVSTKLMIALAAVTAVSGLSIALYTGAEIAIL 172
Cdd:pfam03916  92 SWGVMLLSLYMVVLVLWLAVIFEKDLAALGLPALGFLAKL-------ISLAERVARGLAIIALILAVLLGAYTGFLLSAV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261  173 ASRPLWHQPASPLLWFSTAFFAAIG---LALLIWALLPSSEPNLKTTDLSLVQKTITLTGGLAIILTSIWASNHGHFNLY 249
Cdd:pfam03916 165 YSRPLWNSPLLPPLFLASAISSGLAvllLAMLLAFRFETESPDIGLLHKLEGPVILGEAGLLVAFFVGLYLGGGQKIEAL 244
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515625261  250 EN------DTWGINLGIMTTSILLCMILVLPLQRLSRSKLGIVCIALATILSAWVVRWVTMMEVQTIP 311
Cdd:pfam03916 245 HAalsggfLTVYFWLGVAGLGLAIPLLLSLAVPRLRQNRHAVVIASILVLVGVFSLRFFLLIAGQLTV 312
 
Name Accession Description Interval E-value
PRK14992 PRK14992
tetrathionate reductase subunit TtrC;
3-350 1.17e-54

tetrathionate reductase subunit TtrC;


Pssm-ID: 184954  Cd Length: 335  Bit Score: 183.09  E-value: 1.17e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261   3 ITEVLVPAQEMAWLPWAVQYFFYIGSAyAAAILFLIALIFKDSTSHQFRSALVLVMAIGGIVGPLALTGDLHQPGRAWHF 82
Cdd:PRK14992   2 IEEVLAHPQDISWLPWAVQYFFFIGIA-ACAALFACYLHWRKKDAATEENRALLIAVTCAITAPLALTADLHQTARVWHF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261  83 YAHITPWSWMWVGSLFLPLFSGLAVAtawVYLRDDIAQLKESENPLLKrlsWLTLgqwqvstklmialaaVTAVSGLSIA 162
Cdd:PRK14992  81 YAWPTPWSWMPWGALFLPLFTGFLAL---WFLAQQIKRLFNKSYNVTK---WLAL---------------ASALCAVGLL 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 163 LYTGAEIAILASRPLWHQPASPLLWFSTAFFAAIGLALLIWALLPSSEPNLKTTDL-SLVqkTITLTGGLAIILTSIWAS 241
Cdd:PRK14992 140 IYTGREVSVVLARPIWFSYAFPVAMFLSALQAFFALMIVAARRDSVRLPKILWGQIwTLA--ALGLVVAMWVSGDTLSGT 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 242 NHGHFNLYENDTWGINLGIMTTSILLCMILVLPLQRlSRSKLGIVCIALATILSAWVVRWVTMMEVQTIPRFDVGPFPYE 321
Cdd:PRK14992 218 AIRQWITVALSAKYYAVGWLALWVFTLLFCSLALRH-PLSQLRRVLLVLSALALCWLMRWTLLIQVQTVPKFNAQFNPYS 296
                        330       340
                 ....*....|....*....|....*....
gi 515625261 322 LPIGSSGLLGIVGMCGLWLALALFASEIV 350
Cdd:PRK14992 297 LPGGTDGWLAILGTFGLWIALLIIIRETL 325
NrfD COG3301
Nitrite/polysulfide reductase, membrane component NrfD/PsrC [Inorganic ion transport and ...
7-311 6.52e-29

Nitrite/polysulfide reductase, membrane component NrfD/PsrC [Inorganic ion transport and metabolism];


Pssm-ID: 442530  Cd Length: 297  Bit Score: 113.85  E-value: 6.52e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261   7 LVPAQEMAWLPWAVQYFFYIGSAYAAAILFLIALIFKDSTSHQFRSALVLVMAIGGIVGPLALTGDLHQPGRAWHFYAHI 86
Cdd:COG3301    4 YDVFHQLVWGWPIAIYLFLGGLGAGAFLLAALLDLLGRPESRALRRAGALIALVFLAIGLLLLVLDLGRPLRFWKLLLNP 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261  87 TPWSWMWVGSLFLPLFSGLAVATAWVYLRDDIAqlkesenpllkrlswltlgqWQVSTKLMIALAAVTAVSGLSIALYTG 166
Cdd:COG3301   84 NPTSWMSWGVWLLSLFGLLALLYAALLLKKELR--------------------LPLLEKLRRALALLGALLALLLAAYTG 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 167 AEIAILASRPLWHQPASPLLWFSTAFFAAIGLALLIWALLPSSEPN----LKTTDLSLVQKTITLTGGLAIILTSIWASN 242
Cdd:COG3301  144 FLLSAAKARPLWNTPLLPVLFLVSALSTGAAALLLLALLFGKEPSEelhlLHRLDVALILLELVLLAAFLVGLHLGGAAA 223
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515625261 243 HGHFNLYENDTWGIN--LGIMTTSILLCMILVLPLQRLSRSKLGIVCIALATILSAWVVRWVTMMEVQTIP 311
Cdd:COG3301  224 AAAAEALLTGRYAPLfwGGVVGLGLLLPLLLELAALKLKRSKGLLALAALLVLVGGLLLRYLILYAGQLTP 294
NrfD pfam03916
Polysulphide reductase, NrfD; NrfD is an integral transmembrane protein with loops in both the ...
16-311 2.39e-13

Polysulphide reductase, NrfD; NrfD is an integral transmembrane protein with loops in both the periplasm and the cytoplasm. NrfD is thought to participate in the transfer of electrons, from the quinone pool into the terminal components of the Nrf pathway.


Pssm-ID: 397824  Cd Length: 313  Bit Score: 70.13  E-value: 2.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261   16 LPWAVqYFFYIGSAYAAAILFLIALIFKDSTS---HQFRSALVLVMAIGGIVGPLALTGDLHQPGRAWHFYAHITPWSWM 92
Cdd:pfam03916  13 LPIAV-YLFLIGISAGALILAILYKRFKKNEGkpfNLIIRTGALLAPLAVLAGLLILIFDLGRPWRFWKLLRYYNFSSIM 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261   93 WVGSLFLPLFSGLAVATAWVYLRDDIAQLKESENPLLKRLswltlgqWQVSTKLMIALAAVTAVSGLSIALYTGAEIAIL 172
Cdd:pfam03916  92 SWGVMLLSLYMVVLVLWLAVIFEKDLAALGLPALGFLAKL-------ISLAERVARGLAIIALILAVLLGAYTGFLLSAV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261  173 ASRPLWHQPASPLLWFSTAFFAAIG---LALLIWALLPSSEPNLKTTDLSLVQKTITLTGGLAIILTSIWASNHGHFNLY 249
Cdd:pfam03916 165 YSRPLWNSPLLPPLFLASAISSGLAvllLAMLLAFRFETESPDIGLLHKLEGPVILGEAGLLVAFFVGLYLGGGQKIEAL 244
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515625261  250 EN------DTWGINLGIMTTSILLCMILVLPLQRLSRSKLGIVCIALATILSAWVVRWVTMMEVQTIP 311
Cdd:pfam03916 245 HAalsggfLTVYFWLGVAGLGLAIPLLLSLAVPRLRQNRHAVVIASILVLVGVFSLRFFLLIAGQLTV 312
HybB COG5557
Ni/Fe-hydrogenase 2 integral membrane subunit HybB [Energy production and conversion];
20-344 1.65e-08

Ni/Fe-hydrogenase 2 integral membrane subunit HybB [Energy production and conversion];


Pssm-ID: 444300  Cd Length: 408  Bit Score: 55.99  E-value: 1.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261  20 VQYFFYIGSAYAAAILFLIALIFKDstsHQFRSALVL--VMAIGGIVGPLA-LTGDLHQPGRAWHFYAHITPWSWMWVGS 96
Cdd:COG5557   61 VNFVFWVGIAAGGTLISAILYLFGQ---KWRKPIARLaeALAIFAVICAGLfIVLDLGRPWRLYWLFPYPNFRSPLFWDV 137
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261  97 LFLPLFSGLAVATAWVYLRDDIAQLKESENPLLKRlswltlgQWQVSTKLMIALAAVTAVSGLSIalyTGAEIAILASRP 176
Cdd:COG5557  138 FVISTYLTVSLLFLYLGLIPDLATLRDRAPGFRRK-------RYEKWYLILAGLATPLALSVHTV---TGFLFAGLSARP 207
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 177 LWHQPASPLLWFSTAFFAAIGLALLIWALL---PSSEPNLKTTDLSLVQKTITLTGGLAI------ILTSIWASNHGHFN 247
Cdd:COG5557  208 GWHTTIFPPYFVAGAFASGFAMVILLLIILrkvTKLEDYITDEHLDKLGKLLGAFGLIVLyfylteFFTALYSGNPYEAE 287
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515625261 248 LYENDTWGINLGIMTTSILLCMILVLPL---QRLSRSKLGIVCIALATILSAWVVRWVTMMEVQTIPRFdvgPFPYELP- 323
Cdd:COG5557  288 AFIYLFFGPYAPLFWGEIILGVVLPLQLlwfPKLRRNPKLLFVASILVNIGMWFERYVIVVTGLARPFL---PSSWIGEy 364
                        330       340
                 ....*....|....*....|....*..
gi 515625261 324 ------IGSSglLGIVGMCGLWLALAL 344
Cdd:COG5557  365 sptlveWGLT--LGTIALGLLLFLLFL 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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