|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-760 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 1773.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 4 QLTVTKRNGRKETIDLEKIHRVITWAAEGLHNVSVSQVELKAHIQFYDGITTTDIHETIIKSAADLISEETPDYQYLAAR 83
Cdd:PRK09103 1 SLLVTKRDGRTERINLDKIHRVITWAAEGLHNVSVSQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 84 LSVFHLRKKAYGEYEPPALYDHVAKLVDMGKYDSHLMEDYTKAEFEELDEYIDHKRDLDFSYAAVKQLEGKYFVQNRVTK 163
Cdd:PRK09103 81 LAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDKHLLEDYTEEEFDQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNRVTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 164 EIYESAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATASS 243
Cdd:PRK09103 161 EIYESAQFLYILVAACLFSNYPKETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 244 IVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNR 323
Cdd:PRK09103 241 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 324 GVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFENQDRFEELYVKYENDPSVKRETVKAVELFSLLM 403
Cdd:PRK09103 321 GVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFADQDEFERLYTKYEQDDSIRKKRVKAVELFSLMM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 404 QERASTGRIYIQNVDHCNTHSPFDSEVAPVRQSNLCLEIALPTKPLSNVEDDEGEIALCTLSAFNLGAINELDDLAELSE 483
Cdd:PRK09103 401 QERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINSLDELEELAD 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 484 LVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQG 563
Cdd:PRK09103 481 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 564 RCPSFHETNYAKGLLPIDTYKKDIDLVCEEPLHYDWDSLREEIMEHGLRNSTLTALMPSETSSQISNATNGIEPPRGYVS 643
Cdd:PRK09103 561 ACPWFNETTYAQGILPIDTYKKDLDAICNEPLHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVS 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 644 VKASKDGILKQVVPDFLNLKENYELLWNIGSNDGYLHLVGIMQKFVDQAISANTNYDPSVYDSGKVPMKKLLQDLLTAYK 723
Cdd:PRK09103 641 IKASKDGILKQVVPDYERLKDAYELLWEMPNNDGYLQLVGIMQKFVDQSISANTNYDPSRFPSGKVPMKQLLKDLLTAYK 720
|
730 740 750
....*....|....*....|....*....|....*...
gi 515628392 724 YGVKTLYYHNTRDGAKDDQGDAVQVPEED-CEGGGCKI 760
Cdd:PRK09103 721 FGVKTLYYHNTRDGAEDAQDDLQPSIQDDgCEGGACKI 758
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
88-742 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 684.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 88 HLRKKAYGEYepPALYDHVAKlVDMGKYDSHLMEDytkaEFEELDEYIDHKRDLDFSYAAVKQLEGKYFVQNrVTKEIYE 167
Cdd:COG0209 1 QLRKEALGQY--KSFSEKIKY-VEEGLYDERLLEE----DLEELAAAIDPERDRFFSYNALKTLYDRYLLKD-EDGKPLE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 168 SAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATASSIVRY 247
Cdd:COG0209 73 TPQDLFMRVAMGLAAAEKPEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVEDSLESIFDALKDAALL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 248 VSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNRGVEE 327
Cdd:COG0209 153 SKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDER 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 328 NRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFENqdrFEELYVKYENDPSVKReTVKAVELFSLLMQERA 407
Cdd:COG0209 233 RRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEE---FEEAYEEYEADGRVYK-TIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 408 STGRIYIQNVDHCNTHSPFDsEVAPVRQSNLCLEIALPTkplsnvedDEGEIALCTLSAFNLGAINE-----LDDLAELS 482
Cdd:COG0209 309 ETGEPGILFKDTINRRNPLP-HLGVIHSSNLCGEIPLLP--------YESEDASCNLGSINLAKFVKdgefdWEKLEETV 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 483 ELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQ 562
Cdd:COG0209 380 RTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKER 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 563 GRCPSFHETNYAKGLLPIDTYKKDIdlvcEEPLHYDWDSLREEIMEHGLRNSTLTALMPSETSSQISNATNGIEPPRGYV 642
Cdd:COG0209 460 GAFPAFEGSKYAKGILPFDKYLDDL----LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 643 SVKASKD-GILKQVVPDFL-------------------------------NLKENYELLWNIgSNDGYLHLVGIMQKFVD 690
Cdd:COG0209 536 YVRKVLDgGEFTVVNPYLVralkelglwdeelvekikedgsvqdidelpeELKELYVTAYEI-DPEWHIDMQAARQKHVD 614
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 515628392 691 QAISANTNYDPSvydsgkVPMKKLLQDLLTAYKYGVKTLYYHntRDGAKDDQ 742
Cdd:COG0209 615 QAISKTLNLPND------ATVEDLAELYLLAWKLGLKGIYYY--RDGSRTGQ 658
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-735 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 632.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 145 YAAVKQLEGKYFVQNRVTKEIYESAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSS 224
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 225 CVLIECGDS-LDSINATASSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAAT 303
Cdd:TIGR02506 81 CFLLDVTDDtLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 304 VFYPLWHGEVQSLLVLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFENqdrFEELYVKYE 383
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEE---FEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 384 NDPSV--KRETVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPFDSEVAPVRQSNLCLEIALPTKPlsnveDDEGEIAL 461
Cdd:TIGR02506 238 KDVEArkKIRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQPTDD-----SHKGETAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 462 CTLSAFNLGA--INELDDLAELSELV---VRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSA 536
Cdd:TIGR02506 313 CNLASVNLANfvMEDKFDFSELEDAVriaVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 537 NGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTYKKDIDLVCE-EPLHYDWDSLREEIMEHGLRNST 615
Cdd:TIGR02506 393 RDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTSmAPTEEDWEALRERIKEYGLRNSQ 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 616 LTALMPSETSSQISNATNGIEPPRGYVSVKASKDGILKQVVPDFL--------------------------------NLK 663
Cdd:TIGR02506 473 LTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMkeleelglwdadrrgdivenvgspqpiaaipeTLK 552
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515628392 664 ENYELLWNIgSNDGYLHLVGIMQKFVDQAISANTNYDPsvydsgKVPMKKLLQDLLTAYKYGVKTLYYHNTR 735
Cdd:TIGR02506 553 YKYKTAYEL-DQEALIDMAADRQKFVDQSISLNLFLTE------EVTAKDLLKLLLLAWKKGLKTMYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
223-732 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 553.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 223 SSCVLIECGDSLDSINATASSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAA 302
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 303 TVFYPLWHGEVQSLLVLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFEnqdRFEELYVKY 382
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGE---EFEKEYYER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 383 ENDPSVKRETVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPFdSEVAPVRQSNLCLEIALPTkplsnvedDEGEIALC 462
Cdd:pfam02867 158 EENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQ-KHLGTIKSSNLCTEIVQPT--------SPSEIAVC 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 463 TLSAFNLGAINE------LDDLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSA 536
Cdd:pfam02867 229 NLASINLAKFVEfggtfdFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 537 NGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTYKKDIDLVCEEPLHYDWDSLREEIMEHGLRNSTL 616
Cdd:pfam02867 309 RDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKASKTREDWEELREDIKKYGLRNSQL 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 617 TALMPSETSSQISNATNGIEPPRGYVSVKASKDgilkqvvpdfLNLKENYELLWNIgSNDGYLHLVGIMQKFVDQAISAN 696
Cdd:pfam02867 389 TAIAPTGSISQIAGATESIEPIFSNVYSRKVLS----------EETKEYYKTAYDI-DQKAHIDMAAARQPFVDQSISKT 457
|
490 500 510
....*....|....*....|....*....|....*.
gi 515628392 697 TNYDpsvydsGKVPMKKLLQDLLTAYKYGVKTLYYH 732
Cdd:pfam02867 458 LFLP------NDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
169-734 |
8.50e-171 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 498.99 E-value: 8.50e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 169 AQFLYILVAACLFakypkSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATASSIVRYV 248
Cdd:cd01679 1 PQDRLMRVALGLA-----SGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVDDSLESIYDTIKECAQLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 249 SQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNRGVEEN 328
Cdd:cd01679 76 KIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 329 RVRHMDYGVQLNKLMYSRlvqggnislfspsdvpglydaffenqdrfeelyvkyendpsVKRetvkavELFSLLMQERAS 408
Cdd:cd01679 156 RARDLFYGVWIPDLFMER-----------------------------------------VER------DLWRKILESQFE 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 409 TGRIYIQNVDHCNTHSPFDSeVAPVRQSNLCLEIALPTKPLsnvEDDEGEIALCTLSAFNLGAINELDDLAELSELVVRA 488
Cdd:cd01679 189 TGYPYILFKDTCNRKNPQKH-LGTIKSSNLCTEILQPTSPS---EDEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRA 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 489 LDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGrcpsf 568
Cdd:cd01679 265 LDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG----- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 569 hetnyakgllpidtykkdidlvceeplhydwdslreeimehGLRNSTLTALMPSETSSQISNATNGIEPPRGYVSVKASK 648
Cdd:cd01679 340 -----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVL 378
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 649 DGILKQVVP---DFLNLKENYELLWNIgSNDGYLHLVGIMQKFVDQAISANTNYDPSvydsgkVPMKKLLQDLLTAYKYG 725
Cdd:cd01679 379 SGEFPVVNPhleKDLWEYGLYKTAYEI-DQRWLIDLAADRQKHIDQGQSLNLFLTPP------ATTRDLNSLYFYAWKKG 451
|
....*....
gi 515628392 726 VKTLYYHNT 734
Cdd:cd01679 452 LKTLYYLRT 460
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-760 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 1773.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 4 QLTVTKRNGRKETIDLEKIHRVITWAAEGLHNVSVSQVELKAHIQFYDGITTTDIHETIIKSAADLISEETPDYQYLAAR 83
Cdd:PRK09103 1 SLLVTKRDGRTERINLDKIHRVITWAAEGLHNVSVSQVELRSHIQFYDGIKTSDIHETIIKAAADLISRDAPDYQYLAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 84 LSVFHLRKKAYGEYEPPALYDHVAKLVDMGKYDSHLMEDYTKAEFEELDEYIDHKRDLDFSYAAVKQLEGKYFVQNRVTK 163
Cdd:PRK09103 81 LAIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDKHLLEDYTEEEFDQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNRVTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 164 EIYESAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATASS 243
Cdd:PRK09103 161 EIYESAQFLYILVAACLFSNYPKETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 244 IVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNR 323
Cdd:PRK09103 241 IVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 324 GVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFENQDRFEELYVKYENDPSVKRETVKAVELFSLLM 403
Cdd:PRK09103 321 GVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFADQDEFERLYTKYEQDDSIRKKRVKAVELFSLMM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 404 QERASTGRIYIQNVDHCNTHSPFDSEVAPVRQSNLCLEIALPTKPLSNVEDDEGEIALCTLSAFNLGAINELDDLAELSE 483
Cdd:PRK09103 401 QERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAINSLDELEELAD 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 484 LVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQG 563
Cdd:PRK09103 481 LAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQG 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 564 RCPSFHETNYAKGLLPIDTYKKDIDLVCEEPLHYDWDSLREEIMEHGLRNSTLTALMPSETSSQISNATNGIEPPRGYVS 643
Cdd:PRK09103 561 ACPWFNETTYAQGILPIDTYKKDLDAICNEPLHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVS 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 644 VKASKDGILKQVVPDFLNLKENYELLWNIGSNDGYLHLVGIMQKFVDQAISANTNYDPSVYDSGKVPMKKLLQDLLTAYK 723
Cdd:PRK09103 641 IKASKDGILKQVVPDYERLKDAYELLWEMPNNDGYLQLVGIMQKFVDQSISANTNYDPSRFPSGKVPMKQLLKDLLTAYK 720
|
730 740 750
....*....|....*....|....*....|....*...
gi 515628392 724 YGVKTLYYHNTRDGAKDDQGDAVQVPEED-CEGGGCKI 760
Cdd:PRK09103 721 FGVKTLYYHNTRDGAEDAQDDLQPSIQDDgCEGGACKI 758
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
2-760 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 1229.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 2 NQQLTVTKRNGRKETIDLEKIHRVITWAAEGlHNVSVSQVELKAHIQFYDGITTTDIHETIIKSAADLISEETPDYQYLA 81
Cdd:PHA02572 1 SMIINVIKSSGVSQPFDLEKIHKVLEWACEG-TGVDPSELEENSKIQLRDGMTTKDIQEILIKSAADLISVEEPDYQYVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 82 ARLSVFHLRKKAYGEYEPPALYDHVAKLVDMGKYDSHLMEDYTKAEFEELDEYIDHKRDLDFSYAAVKQLEGKYFVQNRV 161
Cdd:PHA02572 80 ARLLMFALRKQVYGQFEPPSFIDHISKCVNEGKYDPEILSKYSAEEITYLESFIDHDRDFEFTYAGAMQLKEKYLVQDRS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 162 TKEIYESAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATA 241
Cdd:PHA02572 160 TGEIYETPQFAYMLIAMALHQDEPKEDRLEHVIRFYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIESGDSLDSINKTA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 242 SSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKN 321
Cdd:PHA02572 240 MAIVKYISKRAGIGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 322 NRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPG-LYDAFFENQDRFEELYVKYENDPSVKRETVKAVELFS 400
Cdd:PHA02572 320 NKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGeLYDAYFADQDRFRELYEALEKDPSVRKKRIKAQELFL 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 401 LLMQERASTGRIYIQNVDHCNTHSPFdseVAPVRQSNLCLEIALPTKPLsNVEDDEGEIALCTLSAFNLGAINELDDLAE 480
Cdd:PHA02572 400 LLLKERSETGRIYIMFIDHCNNHSPF---KDPIRQSNLCCEIALPTKPL-NHIDGEGEIALCTLSAIVLGNFEDQDEIEE 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 481 LSELVVRALDALLDYQDYPLPAAyKSTMNRRTLGVGVINYAYYLAKNGVKYSDgSANGLTHRTFEAIQYHLLKASVELAK 560
Cdd:PHA02572 476 LAEVAVRALDNLLDYQDYPVPAA-LKAKKRRSLGVGVTNYAHYLAKNFASYED-ANADLVHELFERLQYYLIKASNKLAK 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 561 EQGRCPSFHETNYAKGLLPIDTYKKDIDLVCEEPLHYDWDSLREEIMEHGLRNSTLTALMPSETSSQISNATNGIEPPRG 640
Cdd:PHA02572 554 EKGACEYFSDTKYSRGELPIDWYKKKVDELVAPKYNCDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRG 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 641 YVSVKASKDGILKQVVPDFLNLKENYELLWNIG--SNDGYLHLVGIMQKFVDQAISANTNYDPSVYDSGKVPMKKLLQDL 718
Cdd:PHA02572 634 PVSIKKSKEGPFNQVVPNVETLKDLYDLLWDLAkkGNKGYLTQVAIMQKFVDQAISANTSYDPENYPNGKVPMSVMLDDL 713
|
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 515628392 719 LTAYKYGVKTLYYHNTRDGAKDDQGDAVQVPEEDCEggGCKI 760
Cdd:PHA02572 714 LYFYYYGGKTLYYHNTRDGKGTEDYEIETPKAEDCD--SCKL 753
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
88-742 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 684.61 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 88 HLRKKAYGEYepPALYDHVAKlVDMGKYDSHLMEDytkaEFEELDEYIDHKRDLDFSYAAVKQLEGKYFVQNrVTKEIYE 167
Cdd:COG0209 1 QLRKEALGQY--KSFSEKIKY-VEEGLYDERLLEE----DLEELAAAIDPERDRFFSYNALKTLYDRYLLKD-EDGKPLE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 168 SAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATASSIVRY 247
Cdd:COG0209 73 TPQDLFMRVAMGLAAAEKPEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVEDSLESIFDALKDAALL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 248 VSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNRGVEE 327
Cdd:COG0209 153 SKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDER 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 328 NRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFENqdrFEELYVKYENDPSVKReTVKAVELFSLLMQERA 407
Cdd:COG0209 233 RRLHNFNISVWIPDLFMEAVEEDEDWTLFSPREVPDLYGLYGEE---FEEAYEEYEADGRVYK-TIKARELWRKILESAW 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 408 STGRIYIQNVDHCNTHSPFDsEVAPVRQSNLCLEIALPTkplsnvedDEGEIALCTLSAFNLGAINE-----LDDLAELS 482
Cdd:COG0209 309 ETGEPGILFKDTINRRNPLP-HLGVIHSSNLCGEIPLLP--------YESEDASCNLGSINLAKFVKdgefdWEKLEETV 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 483 ELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQ 562
Cdd:COG0209 380 RTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKER 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 563 GRCPSFHETNYAKGLLPIDTYKKDIdlvcEEPLHYDWDSLREEIMEHGLRNSTLTALMPSETSSQISNATNGIEPPRGYV 642
Cdd:COG0209 460 GAFPAFEGSKYAKGILPFDKYLDDL----LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 643 SVKASKD-GILKQVVPDFL-------------------------------NLKENYELLWNIgSNDGYLHLVGIMQKFVD 690
Cdd:COG0209 536 YVRKVLDgGEFTVVNPYLVralkelglwdeelvekikedgsvqdidelpeELKELYVTAYEI-DPEWHIDMQAARQKHVD 614
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|..
gi 515628392 691 QAISANTNYDPSvydsgkVPMKKLLQDLLTAYKYGVKTLYYHntRDGAKDDQ 742
Cdd:COG0209 615 QAISKTLNLPND------ATVEDLAELYLLAWKLGLKGIYYY--RDGSRTGQ 658
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
145-735 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 632.88 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 145 YAAVKQLEGKYFVQNRVTKEIYESAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSS 224
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAMGLASLEPKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 225 CVLIECGDS-LDSINATASSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAAT 303
Cdd:TIGR02506 81 CFLLDVTDDtLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 304 VFYPLWHGEVQSLLVLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFENqdrFEELYVKYE 383
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEE---FEEEYERLE 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 384 NDPSV--KRETVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPFDSEVAPVRQSNLCLEIALPTKPlsnveDDEGEIAL 461
Cdd:TIGR02506 238 KDVEArkKIRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQPTDD-----SHKGETAV 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 462 CTLSAFNLGA--INELDDLAELSELV---VRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSA 536
Cdd:TIGR02506 313 CNLASVNLANfvMEDKFDFSELEDAVriaVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEA 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 537 NGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTYKKDIDLVCE-EPLHYDWDSLREEIMEHGLRNST 615
Cdd:TIGR02506 393 RDLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTSmAPTEEDWEALRERIKEYGLRNSQ 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 616 LTALMPSETSSQISNATNGIEPPRGYVSVKASKDGILKQVVPDFL--------------------------------NLK 663
Cdd:TIGR02506 473 LTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMkeleelglwdadrrgdivenvgspqpiaaipeTLK 552
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515628392 664 ENYELLWNIgSNDGYLHLVGIMQKFVDQAISANTNYDPsvydsgKVPMKKLLQDLLTAYKYGVKTLYYHNTR 735
Cdd:TIGR02506 553 YKYKTAYEL-DQEALIDMAADRQKFVDQSISLNLFLTE------EVTAKDLLKLLLLAWKKGLKTMYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
223-732 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 553.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 223 SSCVLIECGDSLDSINATASSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAA 302
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 303 TVFYPLWHGEVQSLLVLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFEnqdRFEELYVKY 382
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGE---EFEKEYYER 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 383 ENDPSVKRETVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPFdSEVAPVRQSNLCLEIALPTkplsnvedDEGEIALC 462
Cdd:pfam02867 158 EENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQ-KHLGTIKSSNLCTEIVQPT--------SPSEIAVC 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 463 TLSAFNLGAINE------LDDLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSA 536
Cdd:pfam02867 229 NLASINLAKFVEfggtfdFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 537 NGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTYKKDIDLVCEEPLHYDWDSLREEIMEHGLRNSTL 616
Cdd:pfam02867 309 RDLNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKASKTREDWEELREDIKKYGLRNSQL 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 617 TALMPSETSSQISNATNGIEPPRGYVSVKASKDgilkqvvpdfLNLKENYELLWNIgSNDGYLHLVGIMQKFVDQAISAN 696
Cdd:pfam02867 389 TAIAPTGSISQIAGATESIEPIFSNVYSRKVLS----------EETKEYYKTAYDI-DQKAHIDMAAARQPFVDQSISKT 457
|
490 500 510
....*....|....*....|....*....|....*.
gi 515628392 697 TNYDpsvydsGKVPMKKLLQDLLTAYKYGVKTLYYH 732
Cdd:pfam02867 458 LFLP------NDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
169-734 |
8.50e-171 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 498.99 E-value: 8.50e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 169 AQFLYILVAACLFakypkSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATASSIVRYV 248
Cdd:cd01679 1 PQDRLMRVALGLA-----SGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVDDSLESIYDTIKECAQLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 249 SQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNRGVEEN 328
Cdd:cd01679 76 KIGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 329 RVRHMDYGVQLNKLMYSRlvqggnislfspsdvpglydaffenqdrfeelyvkyendpsVKRetvkavELFSLLMQERAS 408
Cdd:cd01679 156 RARDLFYGVWIPDLFMER-----------------------------------------VER------DLWRKILESQFE 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 409 TGRIYIQNVDHCNTHSPFDSeVAPVRQSNLCLEIALPTKPLsnvEDDEGEIALCTLSAFNLGAINELDDLAELSELVVRA 488
Cdd:cd01679 189 TGYPYILFKDTCNRKNPQKH-LGTIKSSNLCTEILQPTSPS---EDEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRA 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 489 LDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGrcpsf 568
Cdd:cd01679 265 LDNVIDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG----- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 569 hetnyakgllpidtykkdidlvceeplhydwdslreeimehGLRNSTLTALMPSETSSQISNATNGIEPPRGYVSVKASK 648
Cdd:cd01679 340 -----------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVL 378
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 649 DGILKQVVP---DFLNLKENYELLWNIgSNDGYLHLVGIMQKFVDQAISANTNYDPSvydsgkVPMKKLLQDLLTAYKYG 725
Cdd:cd01679 379 SGEFPVVNPhleKDLWEYGLYKTAYEI-DQRWLIDLAADRQKHIDQGQSLNLFLTPP------ATTRDLNSLYFYAWKKG 451
|
....*....
gi 515628392 726 VKTLYYHNT 734
Cdd:cd01679 452 LKTLYYLRT 460
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-731 |
3.35e-113 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 360.66 E-value: 3.35e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 5 LTVTKRNGRKETIDLEKIHRVITWAAEGLHNVSVSQVELKAHIQFYDGITTTDIHETIIKSAADL------------ISE 72
Cdd:PRK07088 3 IKIKKRDGQYEPLQVEKTKKMVKLACEGLYGCDPLELELDSRIQFRDGMTTKEIQKSLIQTAIEKviqnskdnngnnTKK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 73 ETPDYQYLAARLSVFHLRKKA-----YGEYEPPALYDHVAKLVDMGKYDSHLMEDYTKAEFEELDEYIDHKRDLDFSYAA 147
Cdd:PRK07088 83 TNPNWQYVAARLYVFDLYKEArinrhYNSFGYGDYYELVKKLVEEKLYGEYLLQNYSKEEIKELEKYIKPERDFLFNYEG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 148 VKQLEGKYFVQNrVTKEIYESAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVL 227
Cdd:PRK07088 163 LKLLADRYLVKG-FNREILELPQERFMGIAMHLAIPEGKEKRVYYAKKFYDLLSELKATVATPTLSNAGTPFYQLSSCFI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 228 IECGDSLDSINATASSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYP 307
Cdd:PRK07088 242 SVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGAAITLD 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 308 LWHGEVQSLLVLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVP-----GLYDAFFENQDR-FEELYVK 381
Cdd:PRK07088 322 IWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHEIKkvkgySLEDYYDEEDRKeFTKKYLE 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 382 YENDPSVKRETVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPfDSEVAPVRQSNLCLEIALPTKPlSNVEDDE----- 456
Cdd:PRK07088 402 CEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANP-NKHKGMIYSSNLCHEIAQNMSE-SELLEEEiiden 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 457 -----------GEIALCTLSAFNLGAINElDDLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLA 525
Cdd:PRK07088 480 gyyevvqkikaGDMVTCNLNSIVLGNVDD-EELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAIGLGTSGYHHMLA 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 526 KNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGllpidTYKKDIDLVCEEplhydWDSLREE 605
Cdd:PRK07088 559 NNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG-----KYFERRGYNSER-----WKKLKEE 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 606 IMEHGLRNSTLTALMPSETSSQISNATNGIEPPRGYVSVKASKDGILKQVVPD-------FLNLKENYELLWNIGSNdgy 678
Cdd:PRK07088 629 IKKYGMRNGYITAVAPTGSTSNIANTTAGIDPVFKRFFMEEKKGSFTPKTAPDlneenfwYYKEAHTIDQQWSIKAC--- 705
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|...
gi 515628392 679 lhlvGIMQKFVDQAISANtnydpsVYDSGKVPMKKLLQDLLTAYKYGVKTLYY 731
Cdd:PRK07088 706 ----GVRQRHIDQAQSFN------LYITPEYKAKQILNLYIEAWKQGVKTIYY 748
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-755 |
1.52e-110 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 354.03 E-value: 1.52e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 5 LTVTKRNGRKETIDLEKIHRVITWAAEGLHNVSVSQVELKAHIQFYDGITTTDIHETIIKSAADLISEETPDYQYLAARL 84
Cdd:PRK08447 2 ITVVKRNGRIEPLDISKIQKYTSDAVEGLEGVSQSELEVDAKIQFRDGITTEEIQQTLIKTAVDKIDIDRPNWTFVAARL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 85 SVFHLRKKAYGEYEPPALYDHVAKLVDMGKYDSHLMEDYtkaEFEELDEYIDHKRDLDFSYAAVKQLEGKYFVQNRVTKE 164
Cdd:PRK08447 82 FLYDLYHKVSGFTGYNHLKEYFEKGEKEGRILLGLKEKY---DLDDLNAYIKPERDLQFNYLGIKTLYDRYLIKDRNNNP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 165 IyESAQFLYILVAacLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATASSI 244
Cdd:PRK08447 159 I-ELPQHMFMAIA--MFLAQNELDPQKWAKKFYDVISKFEVMLATPTLSNARTTRHQLSSCYIGSTPDNIEGIFDSYKEM 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 245 VRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNRG 324
Cdd:PRK08447 236 ALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGAIAVYLEPWHMDISDFIDLRKNSG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 325 VEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFENqdrFEELYVKYENDPSVKRETVKAVELFSLLMQ 404
Cdd:PRK08447 316 EERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYGEE---FEKRYLEYEKDEKIIKEYINAKELWKKILT 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 405 ERASTGRIYIQNVDHCNTHSPfDSEVAPVRQSNLCLEIALPTKP------------------------------------ 448
Cdd:PRK08447 393 NYFETGLPFLCFKDNANRANP-NAHAGIIRSSNLCTEIFQNTAPnhykikiefedgsieffeeeelvtvdsgitkkakki 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 449 ------------LSNVEDDEGEIALCTLSAFNLGAINELDDLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVG 516
Cdd:PRK08447 472 tsldslkgkkiyIVEKEKKDGKTAVCNLASINLSKINTKEDIERVVPIAIRMLDNVIDLNFYPNRKVKATNLKSRAIGLG 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 517 VINYAYYLAKNGVKYsdGSANGLTH--RTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTYKKDID-LVCEE 593
Cdd:PRK08447 552 VMGEAQMLAEHKIAW--GSKEHLEKidEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFPIDKANEEAKkLVERG 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 594 PL---HYDWDSLREEIMEHGLRNSTLTALMPSETSSQISNATNGIEP--PRGYVSVKASkdGILKQVVPdflNLKEN--- 665
Cdd:PRK08447 630 GLfdsACDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPvyKRKWFEENLS--GLIPVVVP---NLSPEtwq 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 666 -----YELLWNIgsndgYLHLVGIMQKFVDQAISANT--NYDPSvydSGKVpmkklLQDLLT-AYKYGVKTLYYhnTRDG 737
Cdd:PRK08447 705 yytpaYDLDQKD-----LIKAAAVRQKWIDQGQSLNIflSLDKA---SGKY-----LNEIYTlAWKLGLKSTYY--LRSE 769
|
810
....*....|....*...
gi 515628392 738 AKDDQGDAVQVPEEDCEG 755
Cdd:PRK08447 770 SPESEEVSVADRSIECEG 787
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-741 |
5.98e-102 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 330.54 E-value: 5.98e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 7 VTKRNGRKETIDLEKIHRVITWAAEGLHNVSVSQVELKAH--IQFYDGITTTDIHETIIKSAADLISEETPDYQYLAARL 84
Cdd:PRK09209 12 VKEAGNRKLPFDKERLDRYIDQIHAEFPQLDVEDYKRRVFnfVERKESVTADDLVDYLIREAEARVDLEEPEWTFFAARL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 85 SVFHLRKKA-----YGEYEP-PALYDHVAKLVDMGKYDSHLMEDYTKAEFEELDEYIDHKRDLDFSYAAVKQLEGKYFVQ 158
Cdd:PRK09209 92 YLNRLYKRAsrnrfYDASEKyGSFVGLQESLAERGIYSNDLLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLAT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 159 NRVtKEIYESAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSIN 238
Cdd:PRK09209 172 DSD-RNVYELPQERWLTIALYLMQNEPRERRMQLVKEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIDTVDDSLQGIY 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 239 ATASSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQ-TAVKCcSQGGVRGGAATVFYPLWHGEVQSLL 317
Cdd:PRK09209 251 DSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQLNnTAVSV-DQLGQRKGAIAVYLDVWHKDIESFL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 318 VLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVP-----GLYDAFFENQDR--FEELYVKYENDPSVKR 390
Cdd:PRK09209 330 DLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKkvmgwYLEDFYDEKKGDgsFREKYEECVADERLSR 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 391 ETVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPfDSEVAPVRQSNLCLEIAL---PTKPLSN-VEDDE-------GEI 459
Cdd:PRK09209 410 KTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNP-NKHEGMIYSSNLCTEIMQnmsPTVMIQEiISGGQivitkqpGDF 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 460 ALCTLSAFNLGAINELDDLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGL 539
Cdd:PRK09209 489 VVCNLSSINLGRAVTADVLERLIPIQVRMLDNVIDLNQLPVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQY 568
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 540 THRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGllpidTYKKDIDLVCEEplhydWDSLREEIMEHGLRNSTLTAL 619
Cdd:PRK09209 569 ADELYERINYLTIQASMELAKEKGAYPVFKGSDWQTG-----EYFERRGYNSPQ-----WDELAAQVAENGVRNAYLMAV 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 620 MPSETSSQISNATNGIEPPRGYVSVKASKDGILKQVVPDfLNLKEN-------YEL--LWNIGSNdgylhlvGIMQKFVD 690
Cdd:PRK09209 639 APNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVTAPD-LSLDTWpyyekgaYKVdqFWSIRQN-------AARQRHVD 710
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|.
gi 515628392 691 QAISANtnydpsVYDSGKVPMKKLLQDLLTAYKYGVKTLYYHNTRDGAKDD 741
Cdd:PRK09209 711 QSISFN------FYVPSTIRASELLDLHMTAWKEGLKTTYYVRSTDIDIEE 755
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
52-731 |
1.60e-92 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 307.45 E-value: 1.60e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 52 GITTTDIHETIIKSAADLISEETPDYQYLAARLSVFHLRKK---AYGEYEPPALYDHVAKLVDMGKYDSHLMEDYTKAEF 128
Cdd:PRK12364 142 NMSEGESLAALIKAAVELTTQEAPDWEFIAARLLMLQFSKKlgkSLEKLGIHSFYDKIKYLTEEGLYGSYILEHYSREEI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 129 EELDEYIDHKRDLDFSYAAVKQLEGKYFVQNRvTKEIYESAQFLYILVAACLfAKYPKSTRLDYIKRFYDASSTFKISLP 208
Cdd:PRK12364 222 EEAAGFIDPERDKLFTYSGLDLLLKRYVIRTH-SHEPLESPQEMFLGIALHL-AMPEKQDRMGWVKRFYDMLSKLKVTMA 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 209 TPIMSGVRTPTRQFSSCVLIECGDSLDSINATASSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQ-T 287
Cdd:PRK12364 300 TPTLSNARKPFHQLSSCFIDTVPDSLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANdT 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 288 AVkCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNRGveENRVRHMDY--GVQLNKLMYsRLVQ---GGNISLFSPSDVP 362
Cdd:PRK12364 380 AV-AVDQLGMRQGAVAVYLDVWHKDIPEFLQLRTNNG--DDRMKAHDVfpAVCYPDLFW-KMVRddiNQSWYLFCPHEIL 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 363 GLYDAFFEN--QDRFEELYVKYENDPSVKRETVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPfDSEVAPVRQSNLCL 440
Cdd:PRK12364 456 TVKGYALEDyyGEEWEKRYLDCVNDARISKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANP-NKHKGMIYCSNLCT 534
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 441 EIAL---PTKPLS-NVEDDEGE-----------IALCTLSAFNLGAInELDDLAELSELV---VRALDALLDYQDYPLPA 502
Cdd:PRK12364 535 EIAQnmsAIETVStEIETEDGDtvvvtttrpgdFVVCNLASLSLGNI-DLEDEEELEEVVrtvVRALDNVIDLNFYPVPY 613
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 503 AYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGllpidT 582
Cdd:PRK12364 614 AQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTG-----A 688
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 583 YKKDIDLVCEEplhydWDSLREEIMEHGLRNSTLTALMPSETSSQISNATNGIEPPRGYVSVKASKDGILKQVVPD---- 658
Cdd:PRK12364 689 YFRKRGYTSEE-----WQRLAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDPVMKRYFLEEKKGALMPRVAPElsdk 763
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515628392 659 -FLNLKENYELLWNIGsndgyLHLVGIMQKFVDQAISANtnydpsVYDSGKVPMKKLLQDLLTAYKYGVKTLYY 731
Cdd:PRK12364 764 tFWLYKNAHLIDQKWS-----IRAAGVRQRHIDQAQSVN------LYITNEFTMRQVLDLYLLAWEEGVKTIYY 826
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
7-637 |
9.34e-86 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 288.57 E-value: 9.34e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 7 VTKRNGRKETIDLEKIHRVITWAAEGLHN-----VSVSQvelKAHIQFYDGITTTDIHETIIKSAADLISEEtPDYQYLA 81
Cdd:PLN02437 3 VVKRDGRQETVHFDKITARLKKLSYGLSQdhcdpVLVAQ---KVCAGVYKGVTTSQLDELAAETAAAMTTNH-PDYAILA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 82 ARLSVFHLRKKAYGEYEPP--ALYDHVAKlvDMGKYDSHLMED-YT--KAEFEELDEYIDHKRDLDFSYAAVKQLEGKYF 156
Cdd:PLN02437 79 ARIAVSNLHKNTKKSFSETvkDMYNHVNE--RSGLKAPLIADDvYDiiMKNAARLDSEIIYDRDFDYDYFGFKTLERSYL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 157 VqnRVTKEIYESAQFLYILVAACLfakypKSTRLDYIKRFYDASST--FKISLPTPIMSGvrTPTRQFSSCVLIeC--GD 232
Cdd:PLN02437 157 L--KVNGKVVERPQHMLMRVSVGI-----HKDDIESAIKTYHLMSQrwFTHASPTLFNAG--TPRPQLSSCFLI-CmkDD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 233 SLDSINATASSIVrYVSQRAG-IGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGG-VRGGAATVFYPLWH 310
Cdd:PLN02437 227 SIEGIYDTLKECA-VISKSAGgIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGgKRKGAFAIYLEPWH 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 311 GEVQSLLVLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFEnqdRFEELYVKYENDPSVKR 390
Cdd:PLN02437 306 ADIFEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGE---EFERLYTKYEREGKAKK 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 391 eTVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPfDSEVAPVRQSNLCLEIALPTKPlsnveddeGEIALCTLSAFNL- 469
Cdd:PLN02437 383 -VVQAQQLWFAILESQIETGTPYMLFKDSCNRKSN-QQNLGTIKSSNLCTEIIEYTSP--------TETAVCNLASIALp 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 470 ---------------------GAIN---ELDDLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLA 525
Cdd:PLN02437 453 rfvrekgvpleshpsklvgslGSKNryfDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFI 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 526 KNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTYKkdidlvCEEPLHYDWDSLREE 605
Cdd:PLN02437 533 LLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWG------VTPSGRWDWAALREM 606
|
650 660 670
....*....|....*....|....*....|..
gi 515628392 606 IMEHGLRNSTLTALMPSETSSQISNATNGIEP 637
Cdd:PLN02437 607 ISKNGVRNSLLVAPMPTASTSQILGNNECFEP 638
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-645 |
1.75e-84 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 288.01 E-value: 1.75e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 4 QLTVTKRNGRKETIDLEKIHRVITWAAEGLHNVSVSQVELKAHIQFYDGITTTDIHETIIKSAADLIsEETPDYQYLAAR 83
Cdd:PRK07207 148 GLNVTLDDGVRRPLDMARLRALIEEACEGLEAVDAEPILAETLKNLYDGVPMDEVYKALILAARTLI-EKEPNYSYVTAR 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 84 LSVFHLRKKAYGEYEPPALYDHVaklvDMGKYDSHLMEDYTKA--EFEELDE------------YIDHKRDLDFSYAAVK 149
Cdd:PRK07207 227 LLLDTLRREALGFLGVPEEVTQA----EMATRYAEYFPAFIKKgiEAELLDPklaqfdlerlgaALDPERDLQFTYLGLQ 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 150 QLEGKYFVQNRVTKeiYESAQFLYILVAACLfakypkstRLDYIKR------FYDASSTFKI--SLPTPIMSGVRTPtrQ 221
Cdd:PRK07207 303 TLYDRYFLHVDGTR--IELPQAFFMRVAMGL--------ALNEIDRearaieFYNLLSSFDFmsSTPTLFNSGTLRP--Q 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 222 FSSCVLIECGDSLDSI------NATASsivRYVsqrAGIGINAGRIRALGSEIR--NGEAfhTGCIPFYKYFQ-TAVkCC 292
Cdd:PRK07207 371 LSSCYLTTVPDDLDGIyeaikdNALLS---KFA---GGLGNDWTPVRALGSHIKgtNGKS--QGVVPFLKVVNdTAV-AV 441
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 293 SQGGVRGGAATVFYPLWHGEVQSLLVLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFENq 372
Cdd:PRK07207 442 NQGGKRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLFGKA- 520
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 373 drFEELYVKYENdpSVKR------ETVKAVELF----SLLMQerasTGRIYIQNVDHCNTHSPfDSEVAPVRQSNLCLEI 442
Cdd:PRK07207 521 --FEEAYTAYEA--KAARgeiklfKKIPAVDLWrkmlSMLFE----TGHPWITFKDPCNLRSP-QQHVGVVHSSNLCTEI 591
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 443 ALptkplsNVEDDEgeIALCtlsafNLGAIN---------ELDdLAELSELV---VRALDALLDYQDYPLPAAYKSTMNR 510
Cdd:PRK07207 592 TL------NTSDDE--IAVC-----NLGSVNlvahikdgaKLD-HEKLKRTVstaMRMLDNVIDINYYAVPKARNSNLRH 657
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 511 RTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTykkdIDLV 590
Cdd:PRK07207 658 RPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSYYAIWASTELAEERGRYSSYEGSLWSRGILPIDS----LKLL 733
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515628392 591 CEEPLHY---------DWDSLREEIMEHGLRNSTLTALMPSETSSQISNATNGIEPPRGYVSVK 645
Cdd:PRK07207 734 AEARGGYlevdrsstlDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPTYQNLYVK 797
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-731 |
1.81e-79 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 271.80 E-value: 1.81e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 5 LTVTKRNGRKETIDLEKIHRVITWAAEGL-HNVS-VSQVELKAHIQFYDGITTTDIHETIIKSAADLISEEtPDYQYLAA 82
Cdd:PRK06539 3 ITVVKRDGSKEPYDANKVNAAIEDAARGLdDAITwVTQLASELEITLFDGITTQQLDEAVIQVALQNVKDD-PAFDTVAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 83 RLSVFHLRKKAYGEYEPPA-LYD--------HVAKLVDMGKYDSHLMEDYtkaEFEELDEYIDHKRDLDFSYAAVKQLEG 153
Cdd:PRK06539 82 RLLLKKIYKRVLGDYDSPEeLQDlhanhfrrTIEKGVAEGLLDSRLGGLF---DLERLAAALDPTRDELLKYIGVVTLNN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 154 KYFVQNRvTKEIYESAQFLYILVAA--CLFAKYPKSTRLdyikRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECG 231
Cdd:PRK06539 159 RYGIRAR-NGDALEVPQYFWMRIAMglSLNEDDPTSSAL----AFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 232 DSLDSINATASSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHG 311
Cdd:PRK06539 234 DDIEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHM 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 312 EVQSLLVLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFENqdrFEELYVKYENDPSVKR- 390
Cdd:PRK06539 314 DFPEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKA---FSKRYAQYVEQAEAGRi 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 391 ---ETVKAVELFSLLMQERASTGRIYIQNVDHCNTHSpFDSEVAPVRQSNLCLEIALPtkplsnveDDEGEIALCTLSAF 467
Cdd:PRK06539 391 rmfKRITAREQFRAILMSLQTTSHPWLTWKDTINNRA-LNNNTGTIHLSNLCTEICLP--------QDRDNVSVCNLASI 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 468 NLG---AINELD--DLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHR 542
Cdd:PRK06539 462 NLSrhlADGELDwaQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDR 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 543 TFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTYK-----KDIDLVCEEPLHYDWDSLREEImEHGLRNSTLT 617
Cdd:PRK06539 542 IMEHISYAAIDESADLAAERGAYPNFEGSRWSRGMVPVDSIAlleadRGVPVDVNRTTRLDWDALRAKV-RGGMRNATLM 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 618 ALMPSETSSQISNATNGIEP------PRGYVS----------VKASKD-GILKQVVPDFL--------------NLKENY 666
Cdd:PRK06539 621 AIAPTASIGLVAGTTPGLDPqfsqifSRSTSSgkflevnrnlVADLKElGLWETVREEILrsqgdiqeiaaipdEIKALY 700
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515628392 667 ELLWNIgSNDGYLHLVGIMQKFVDQAISANTNYDP-SVYDsgkvpmkklLQDLLT-AYKYGVKTLYY 731
Cdd:PRK06539 701 RTSFQL-SPYAFLEVAARAQKWVDQAISRNMYLESrDIGD---------MMDIYTaAWEMGVKTTYY 757
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
7-731 |
4.10e-79 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 274.52 E-value: 4.10e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 7 VTKRNGRKETIDLEKIHRVITWAAEGLHNVSVSQVELK-AHIQFYDGITTTDIHETIIKSAADLISEEtPDYQYLAARL- 84
Cdd:PRK12365 238 VLSKDGSTYTMTKSQLLAHFAWACSRFPETTDAALLADmAFANFYSGIKESEVVLACIMAARANIEKE-PDYAFVAAELl 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 85 --SVFH--LRKKAYGEYEPPALYDHVAKLVDMGkyDSHLMEDYTKA-EFEELDEYIDHKRDLDFSYAAVKQLEGKYFVQN 159
Cdd:PRK12365 317 ldVVYKeaLGKSKYDEDLEEAHKDHFKRYILEG--DTYRLNPELKHyDLDALAEALDLSRDLQFSYMGVQNLYDRYFNHH 394
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 160 RVTKeiYESAQFLYILVAACLfAKYPKSTRLDYIKRFYDASSTFKISLPTPIM--SGVRTptRQFSSCVLIECGDSLDSI 237
Cdd:PRK12365 395 EGRR--LETPQIFWMRVSMGL-ALNEGQDKTSWAITFYNLLSTFRYTPATPTLfnSGMRH--SQLSSCYLSTVQDDLVHI 469
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 238 NATASSIVRYVSQRAGIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLL 317
Cdd:PRK12365 470 YKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAVCVYLEVWHLDYEDFL 549
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 318 VLKNNRGVEENRVRHMDYGVQLNKLMYSRLVQGGNISLFSPSDVPGLYDAFFEnqdRFEELYVKYEN--DPSVKR--ETV 393
Cdd:PRK12365 550 ELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAYGE---EFEKLYEEYERkvDTGEIRlyKKV 626
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 394 KAVELFSLLMQERASTGRIYIQNVDHCNTHSPFDsEVAPVRQSNLCLEIALPTKplsnveddEGEIALCTLSAFNL---- 469
Cdd:PRK12365 627 EAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQD-HKGVVRCSNLCTEILLNCS--------ETETAVCNLGSINLvehi 697
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 470 --GAINElDDLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAI 547
Cdd:PRK12365 698 vnDGLDE-EKLSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELI 776
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 548 QYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDT------YKKDIDLVCEEPLHYDWDSLREEIMEHGLRNSTLTALMP 621
Cdd:PRK12365 777 AYYAILASSLLAKERGTYSSYKGSKWDRGYLPIDTiellkeYRGEANLLMDTSSRKDWEPVRSLIKEYGMRNSQLMAIAP 856
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 622 SETSSQISNATNGIEPPRGYVSVKASKDGilKQVVPDFLNLKENYEL-LW------NIGSNDGYL--------HLVGIM- 685
Cdd:PRK12365 857 TATISNIIGVTQSIEPTYKHLFVKSNLSG--EFTIPNVYLIEKLKKLgIWdadmldDLKYFDGSLleieripdHLKKIFl 934
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515628392 686 -----------------QKFVDQAISANtnydpsVYDSgKVPMKKLLQDLLTAYKYGVKTLYY 731
Cdd:PRK12365 935 tafeiepewiiecasrrQKWIDMGQSLN------LYLA-EPDGKKLSNMYLTAWKKGLKTTYY 990
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
193-732 |
9.64e-61 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 210.08 E-value: 9.64e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 193 IKRFYDASSTFKISLPTPimsgvrtpTRQFSSCVLIECGDSLD---------------SINATASSIVRYVSQR--AGIG 255
Cdd:cd00576 1 AERIYEAVKSGVITVGRP--------DLPFTGCVLVDYGDSLDpgikgvnetaksineAIQKTYQIIALAASNQngGGVS 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 256 INA--GRIRALGSEIRN-GEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGE-----VQSLLVLKNNRGVEE 327
Cdd:cd00576 73 FARasSILSPYGSRDYAkGSGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHKGkgdkiSQEFLNLALANGGEG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 328 NRVRHMDYGVQLNKLMYSRLvqggnislfspsdvpglydaffenqdrfeelyvkyendpsvkretVKAVELFSLLMQERA 407
Cdd:cd00576 153 IPLNFPNLSVRVSSDKPGIL---------------------------------------------VKAVELKQLIAEEAR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 408 STGRIYIQNVdhcnthspfdsevapvrqsnlcleialptkplsnveddegeiALCTLSAFNLGAINE----------LDD 477
Cdd:cd00576 188 KTGSPGIFND------------------------------------------ELCNLVSLNLARIMEkaingsmdvvLEE 225
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 478 LAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNG-VKYSDGSANGLTHRTFEAIQYHLLKASV 556
Cdd:cd00576 226 LEELAFLAVRALDCVIDSHDERIPTIELGGDERRTVGLGIAGVADLLIKLGlEKVGDPEADDLAAELVDQLKKHLVKATN 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 557 ElakeqgrcpsfhetnyakgllpidtykkdidlvceeplhydwdslreeimehgLRNSTLTALMPSETSSQISNATNGIE 636
Cdd:cd00576 306 E-----------------------------------------------------RGFNFLLGLSPSESNSSGAPATNGVS 332
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 637 PPRGYVsvkaskdgilkqvvpdflnlkenYELLWNIGSNDGYLHLVGIMQKFVDQAISANTNYDPSvydsgKVPMKKLLQ 716
Cdd:cd00576 333 PSRG*I-----------------------AIVLNGDIGPEESLASVAILQFYADNGISDTITIPDS-----ATNLDQLLA 384
|
570
....*....|....*.
gi 515628392 717 DLLTAYKYGVKTLYYH 732
Cdd:cd00576 385 VIDGAAAIKTTHVRVN 400
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
135-731 |
5.31e-54 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 196.72 E-value: 5.31e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 135 IDHKRDL---DFSYAAvkqLEGKYFVQNrvtkeiyESAQFLYILVAACLFAKYPkstrlDYIKRFYDASSTFKISLPTPI 211
Cdd:PRK09102 13 IDRSRDAwltEFGKAT---LRDRYLLEG-------ESYQDLFARIAEAYADIDP-----EHAQRFYDYMSRGWFMPATPV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 212 MSGVRTpTRQFS-SCVLIECGDSLDSINATASSIVRYVSQRAGIGINAGRIRALGSEIR-NGEAfhTGCIPFYKYFQTAV 289
Cdd:PRK09102 78 LSNGGT-DRGLPiSCFLNYVEDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPIRnNGKS--SGIIPFIKVMDSLT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 290 KCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNRGVEENRVRHMDYGVqlnklmysrlvqggNISlfspsdvpglyDAFF 369
Cdd:PRK09102 155 LAISQGSLRRGSFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGV--------------CVT-----------DEFM 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 370 ENQDRFEELYVKYENDPSVKReTVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPfdsEV-----APVRQSNLCLEIAL 444
Cdd:PRK09102 210 EAVEDGDEWDLISPKDKSVIR-TVKARDLWAKILETRIETGEPYLLFIDNVNRALP---EVykdlgLKVKASNLCSEITL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 445 PTKPLSNVEDdegEIALCTLSAFNLGAINELDDLAELSELVVRALDALLdyQDY------PLPAAYKSTMNRRTLGVGVI 518
Cdd:PRK09102 286 PTGIDHLGED---RTAVCCLSSLNLEYYDEWKDTDAFIEDLMRFLDNVL--QDFidkapdEMERAKYSAMRERSVGLGVM 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 519 NYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNyakgllpidtykkdidlvceeplhyd 598
Cdd:PRK09102 361 GFHSYLQSKMIPFESVMAKQWNKKIFKHIREQADKASKELAKEKGECPDAAGYG-------------------------- 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 599 wdslreeIMEhglRNSTLTALMPSETSSQIS-NATNGIEPPRG--YVSVKAS-----KDGILKQVvpdflnLKE---NYE 667
Cdd:PRK09102 415 -------VMR---RFSTKMAIAPTASISIILgNTSPGIEPIAAnyYTHKTLKgsftvKNKYLEKL------LEEkgkDTD 478
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 668 LLWN-IGSNDG-YLHL-------------------------VGIMQKFVDQAISANtnydpsVYDSGKVPMKKLLQDLLT 720
Cdd:PRK09102 479 EVWSsILTNEGsVQHLdflseeekdvfktafeidqrwiielAADRQKYIDQAQSLN------LFLPANVPKRDLNKLHFE 552
|
650
....*....|.
gi 515628392 721 AYKYGVKTLYY 731
Cdd:PRK09102 553 AWKKGVKSLYY 563
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
165-742 |
9.82e-49 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 181.37 E-value: 9.82e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 165 IYESAQFLYILVAACLFA---KYPKSTRLDYIKRFYDASSTFKISLPTPIMSGV-RTPTRQFSSCVLIECGDSLDSINAT 240
Cdd:TIGR02504 15 IIESPEDLFRRVARALAAaedKYNSPVWKQWYERFYDLMVNLGFIPNSPTLMNAgGTRLGQLSACFVLPVEDSMEDIFEA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 241 ASSIVRYVSQRAGIGINAGRIRALGSEIR--NGEAfhTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLV 318
Cdd:TIGR02504 95 LKEAALIFKRGGGVGYNFSTLRPKGDLVSgtGGVA--SGPVSFMRVFDSAAGVVKQGGTRRGAQMGILDVWHPDIEEFIE 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 319 LKNNRGVeenrvrhmdygvqlnklmysrlVQGGNISLfspsdvpGLYDAFFENQDRFEELYVKYENDPSVKreTVKAVEL 398
Cdd:TIGR02504 173 AKAKEGK----------------------LQNFNISV-------GVTDEFMEAVENDEEYELRNPRTGEYK--EVDAREL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 399 FSLLMQ---ERASTGRIYIQNVdhcNTHSPFDsEVAPVRQSNLCleialptkplsnveddeGEIALCTLSAFNLGAIN-- 473
Cdd:TIGR02504 222 WDKIVEsawKSAEPGVLFIDTI---NKWHTCP-YGGRINATNPC-----------------GEQPLLPYESCNLGSINla 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 474 -------------ELDDLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLT 540
Cdd:TIGR02504 281 kfvkndfgdeasfDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELA 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 541 HRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTYKKDidlvceeplhYDWDsLREEIMEHGLRNSTLTALM 620
Cdd:TIGR02504 361 EEVMEFIADAAYRASAELAKERGAFPLYDASKYPMGRAMGARIPSA----------LPAE-IREAIRKYGIRNAQLTTIA 429
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 621 PSETSSQISNATNGIEPPRGYVSVKA-SKDGILKQVVPDFLN-LKE-------NYELLWNIGSNDGYL------------ 679
Cdd:TIGR02504 430 PTGTISLIAGTSSGIEPVFALVYFRNvTVGGELLEVNPLVELaLRElgyysdeIVKYVDEKGTVEGAPgpeelpkvfvta 509
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515628392 680 -------HL--VGIMQKFVDQAISANTNY--DPSVYDSGKVpmkkllqdLLTAYKYGVK--TLYyhntRDGAKDDQ 742
Cdd:TIGR02504 510 mdispedHVlmQAAIQPWVDSSISKTINMpsDATVEDVKAV--------YLEAWKLGLKgiTVY----RDGSRSSQ 573
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
193-737 |
1.93e-48 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 177.81 E-value: 1.93e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 193 IKRFYDASSTFKISLPTPIMSGVRTPTR-QFSSC-VLIECGDSLDSINATASSIVRYVSQRAGIGINAGRIRALGSEIRN 270
Cdd:cd02888 1 ADEFFYLLLSQGFIPNSPTLMNAGTGELgQLSACfVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 271 GEAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKnnrgVEENRVRHMdygvqlnklmysrlvQG 350
Cdd:cd02888 81 TGGVASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFIDAK----MKEEKTVVL---------------QN 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 351 GNISLfspsdvpGLYDAFFE--NQDRFEELYVKYENDPSVKRETVKAVELFSLLMQ---ERASTGRIYIQNVdhcNTHSP 425
Cdd:cd02888 142 FNISV-------AVTDAFMEavENDEPWELRNPREPDTGKVYRTVPARELWDKIVEaawDSADPGVLFIDTI---NRWNP 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 426 FDsEVAPVRQSNLCleialptkplsnveddeGEIALCTLSAFNLGAIN--------------ELDDLAELSELVVRALDA 491
Cdd:cd02888 212 LP-GLGRINATNPC-----------------GEQPLLPYESCNLGSINlskfvknpfggasfDFERLREAVRLAVRFLDN 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 492 LLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHET 571
Cdd:cd02888 274 VIDVNRYPLPEIAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDAS 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 572 NYAKGLLPIdtykkdidlvceePLHYDWDSLREEIMEHGLRNSTLTALMPSETSSQISNATNGIEPPRGYVSvkaskdgi 651
Cdd:cd02888 354 RYLMLKVIV-------------NAKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPIFSPED-------- 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 652 lkqvvpdflnlkenyellwnigsndgylHL--VGIMQKFVDQAISANTNY--DPSVYDSGKVpmkkllqdLLTAYKYGVK 727
Cdd:cd02888 413 ----------------------------HVrmQAALQPWVDGAISKTINLpnDATVEDVEAV--------YLLAWKLGLK 456
|
570
....*....|..
gi 515628392 728 --TLYyhntRDG 737
Cdd:cd02888 457 giTVY----RDG 464
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
192-728 |
5.91e-25 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 111.10 E-value: 5.91e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 192 YIKRFYDASSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATASSIVRYVSQRAGIGINAGRIRALGSEIRNG 271
Cdd:PRK06406 219 YINKFEEVMSNLKFVPNSPTLMNAGTKLGQLSACFVLPVPDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVAST 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 272 EAFHTGCIPFYKYFQTAVKCCSQGGVRGGAATVFYPLWHGEVQSLLVLKNNrgveENRVrhmdygvqlnklmysrlVQGG 351
Cdd:PRK06406 299 KGVASGPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSKDS----ENKV-----------------LSNF 357
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 352 NISLfspsdvpGLYDAFFENQDRFEelYVKYENdPSVKRET--VKAVELFSLLMQERASTGRIYIQNVDHCNTHSPFdSE 429
Cdd:PRK06406 358 NISV-------AVTDEFFDKLDNDD--YYPLRN-PRNGKEVkrIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPV-KN 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 430 VAPVRQSNLCleialptkplsnveddeGEIALCTLSAFNLGAIN----------ELDDLAELSELVVRALDALLDYQDYP 499
Cdd:PRK06406 427 LGEIESTNPC-----------------GEQPLLPYESCNLGSINlskfvengkiDWDRLRETVHIATRFLDNVIDANKFP 489
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 500 LPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYakgllp 579
Cdd:PRK06406 490 VPQIKEMTRMTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPAWYGSEW------ 563
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 580 idtYKKDIDlvceeplhydwdslreeimehgLRNSTLTALMPSETSSQISNATNGIEP---------------------- 637
Cdd:PRK06406 564 ---EKKGIK----------------------MRNSTTTTIAPTGTISIIAGCSSSIEPlfaiafvrhvlngqellevnpl 618
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 638 ------PRGYVS----VKASKDGILKQV-VPDflNLKENYELLWNIGSnDGYLHLVGIMQKFVDQAISANTN--YDPSVY 704
Cdd:PRK06406 619 feeitrKRGLYSeelmRKVAETGNLQNIdVPE--DIKRIFVTAHEIDP-QWHVLMQATFQRYCDSGVSKTINlrYDATPE 695
|
570 580
....*....|....*....|....*.
gi 515628392 705 DSGKVPM--KKLLQDLLTAYKYGVKT 728
Cdd:PRK06406 696 DIAKAYRlaKDLHCKGITVYRDKSKT 721
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
458-677 |
1.06e-21 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 101.38 E-value: 1.06e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 458 EIALCTLSAFNLGAINELDD----------LAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKN 527
Cdd:PRK08332 1304 EYESCNLASINLAKFVKYDEngkpyfdwdeYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTRRIGVGMMGLADALFKL 1383
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 528 GVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAKGLLPIDTYKKdidlvcEEPLHYDWDSLREEIM 607
Cdd:PRK08332 1384 GIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELPVEGFYH------PEIWNLPWDKLVEEIK 1457
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515628392 608 EHGLRNSTLTALMPSETSSQISNATNGIEPPRGYVSVKASKDGILKQVVPDF-LNLKE----NYELLWNIGSNDG 677
Cdd:PRK08332 1458 KYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFeAELKKrglySEELLKKISDNYG 1532
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
140-751 |
1.86e-21 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 99.62 E-value: 1.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 140 DLDFSYAAVKQLEGKYFVQNRVTKEIyESAQFLYILVAACLFA---KYPKSTRLDYI-KRFYDASSTFKIsLP-TPIMSG 214
Cdd:PRK08665 9 DMKLTDNALTVLEKRYLKKDEDGKPI-ETPEDMFRRVARTIAAaelIYDSKADVEALaDRFYDLMTSLEF-LPnSPTLMN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 215 VRTPTRQFSSCVLIECGDSLDSINATassivryVSQRA-------GIGINAGRIRALGSEIRNGEAFHTGCIPFYKYFQT 287
Cdd:PRK08665 87 AGRELGQLSACFVLPVGDSIEEIFDA-------VKHAAlihksggGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 288 AVKCCSQGGVRGGAatvfyplwhgevqsllvlknNRGVEenRVRH---MDY------GVQLNKLmysrlvqggNISLfsp 358
Cdd:PRK08665 160 ATEAIKQGGTRRGA--------------------NMGIL--RVDHpdiMEFitckedNGELTNF---------NISV--- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 359 sdvpGLYDAFFENQDRFEElyvkYE-NDPSVKR--ETVKAVELFSLLMQERASTGRIYIQNVDHCNTHSPfDSEVAPVRQ 435
Cdd:PRK08665 206 ----AITEAFMEAVEADEE----YDlINPRTGEvvGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNP-TPHLGEIES 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 436 SNLCleialptkplsnveddeGEIALCTLSAFNLGAIN----------ELDDLAELSELVVRALDALLDYQDYPLPAAYK 505
Cdd:PRK08665 277 TNPC-----------------GEQPLLPYESCNLGSINlskmvkngdvDWEKLREVVHLAVRFLDNVIDANKYPLPQIEE 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 506 STMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLKASVELAKEQGRCPSFHETNYAK-GLLPIdtyk 584
Cdd:PRK08665 340 MTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQDEAHAASRELAEERGPFPNYEGSIYDKdGLGPM---- 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 585 kdidlvceeplhydwdslreeimehglRNSTLTALMPSETSSQISNATNGIEPPRGYVSVKASKDG-ILKQVVPDFLN-L 662
Cdd:PRK08665 416 ---------------------------RNATVTTIAPTGTISIIAGCSSGIEPLFALSFTRNVMDGeRLVEVNPVFEAaA 468
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 663 KEN--Y--ELLWNI---GSNDGYLHL--------VGIM--------------QKFVDQAISANTNY--DPSVYDSGKVpm 711
Cdd:PRK08665 469 KEEgfYseELMEKIaekGSIQDIDEVpedvrrvfVTAHdispewhvrmqaafQKHTDNAVSKTVNFpnEATIEDVREV-- 546
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 515628392 712 kkllqdLLTAYKYGVK--TLYyhntRDGAKDDQ----GDAVQVPEE 751
Cdd:PRK08665 547 ------YRLAYELGCKgvTIY----RDGSRDEQvlstGKKEKKEEE 582
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
5-92 |
5.58e-17 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 76.15 E-value: 5.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 5 LTVTKRNGRKETIDLEKIHRVITWAAEGLHNVS---VSQVELKAHIQFYDGITTTDIHETIIKSAADLiseetPDYQYLA 81
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPDQAdelASEVEEELEKSLEDGISTEEIQDLVEKTLAEH-----PDYAVAR 75
|
90
....*....|.
gi 515628392 82 ARLSVFHLRKK 92
Cdd:pfam03477 76 AYILYRNLRKE 86
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
392-754 |
5.23e-15 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 79.12 E-value: 5.23e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 392 TVKAVELFSLL---MQERASTGRIYIQNVDHCNTHSPFDSEVAPvrqSNLCLEiaLPTKPLSnveddegeiaLCTLSAFN 468
Cdd:PRK08115 432 KIKAKELWNLInicATYSAEPGIFFIDNANEMTNAKAYGQKVVA---TNPCGE--QPLAPYS----------VCNLAAIN 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 469 LGAIN-------ELDDLAELSELVVRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTH 541
Cdd:PRK08115 497 LANMAdketktvDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVD 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 542 RTFEAIQYHLLKASVELAKEQGRCP---------------SFHETNYAKGlLPIDtykkdidlvceeplhydwdsLREEI 606
Cdd:PRK08115 577 QIFETIATTAYRTSIELAKEKGSFPflvgqteeetaklreAFINTGYMKK-MPED--------------------IREDI 635
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 607 MEHGLRNSTLTALMPSETSSQISNATNGIEPprgYVSVKASKDGIL-------KQVVPDFLNLK----ENYELLWNIGSN 675
Cdd:PRK08115 636 LKYGIRNSHLLTVAPTGSTGTMVGVSTGLEP---YFSFSYYRSGRLgkfievkADIVQEYLDKHpeadENHLPEWFISAM 712
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 676 D----GYLHLVGIMQKFVDQAISANTNyDPSVYDSGKVpmKKLLQDLltaYKYGVK--TLYYhntrDGAKDDQGDAVQVP 749
Cdd:PRK08115 713 ElkpeAHADVQCIIQRWVDSSLSKTVN-APKGYTVEQV--QKVYERL---YRGGAKggTVYV----DGSRDAQVLTLKAE 782
|
....*
gi 515628392 750 EEDCE 754
Cdd:PRK08115 783 ENDLD 787
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
143-218 |
8.16e-14 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 66.88 E-value: 8.16e-14
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515628392 143 FSYAAVKQLEGKYFVQNRvTKEIYESAQFLYILVAACLFAKYPKSTRLDYIKRFYDASSTFKISLPTPIMSGVRTP 218
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDE-DGELLETPQDMFMRVALALAGAELEEDRLELAEEFYDLLSSLKFLPATPTLMNAGTP 75
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
477-642 |
1.14e-13 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 74.45 E-value: 1.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 477 DLAELSELV---VRALDALLDYQDYPLPAAYKSTMNRRTLGVGVINYAYYLAKNGVKYSDGSANGLTHRTFEAIQYHLLK 553
Cdd:PRK06948 326 DFAALATAVriqVRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYA 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 554 ASVELAKEQGRCPSFHETNYAKG-----LLPIdtykkdidlvceeplhydwdSLREEIMEHGLRNSTLTALMPSETSSQI 628
Cdd:PRK06948 406 ASAALAAERGAYPLCDPAAHLDAlragpPLPH--------------------AVCHAIARHGLRNSHLLSFAPVGSVSLA 465
|
170
....*....|....*.
gi 515628392 629 --SNATNGIEPPRGYV 642
Cdd:PRK06948 466 fgDNCSPGIEPARAWI 481
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
214-660 |
2.86e-06 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 51.12 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 214 GVRTPTrQFSSCVLIECGDSLDSINATASS---IVRYVSqraGIGINAGRIRALGsEIRNGEAFHTGCIPFYKYFQT--- 287
Cdd:PRK06556 142 GTESPQ-QVSACFILSVDDSMESILNWYKEegmLFKGGS---GTGTNLSRIRSSK-ELLSGGGTASGPVSFMRGADAsag 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 288 AVKccSQGGVRGGAATVFYPLWHGEVQSLLVLKNNrgvEENRVR---HMDYGVQLNKLMY-SRLVQGGNISL-FSpsdvp 362
Cdd:PRK06556 217 TIK--SGGATRRAAKMVILDVDHPDIEEFIETKAK---EEDKIRalrDAGYDMDLGGEAYsSVQYQNANNSVrVS----- 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 363 glyDAF---FENQDRFEELYVKyenDPSVKrETVKAVELFSLLMQ---ERASTGRIYIQNVDHCNThSPfdsEVAPVRQS 436
Cdd:PRK06556 287 ---DEFmraVENDGEFGLRART---DGEVI-ETVDAKELFRKIAEaawECADPGIQYDDTINDWHT-CP---ESGRINAS 355
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 437 NLCLEIALptkpLSNveddegeialctlSAFNLGAIN-----------ELDDLAELSELVVRALDALLDYQDYPLPAAYK 505
Cdd:PRK06556 356 NPCSEYMF----LDN-------------SSCNLASLNlmkflrddgtfDVESFRHAVELVITAMEISICFADFPTEKIAR 418
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 506 STMNRRTLGVGVINYAYYLAKNGVKY-SDGSanglthRTFEAIQYHLL-----KASVELAKEQGRCPSFHET-------- 571
Cdd:PRK06556 419 NTRAFRQLGLGYANLGALLMATGLPYdSDGG------RALAAAITSLMtgeayRRSAELAGVVGPFEGYARNaephlrvm 492
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628392 572 -NYAKGLLPIDTYKkdidlVCEEPLH----YDWDSLREEIMEHGLRNSTLTALMPSETssqISNA----TNGIEPPRGYV 642
Cdd:PRK06556 493 rKHAAANDAIRPLG-----EVDAALLeaakEAWDDALELGEKNGYRNAQASVLAPTGT---IGFMmdcdTTGIEPDFALV 564
|
490 500
....*....|....*....|..
gi 515628392 643 SVKASKDG----ILKQVVPDFL 660
Cdd:PRK06556 565 KYKKLVGGgsmkIVNQTVPRAL 586
|
|
| |
