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MULTISPECIES: argininosuccinate synthase [Vibrio]
Protein Classification
argininosuccinate synthase ( domain architecture ID 10011457 )
argininosuccinate synthase reversibly catalyzes the ATP-dependent condensation of a citrulline with an aspartate to give argininosuccinate
List of domain hits
Name
Accession
Description
Interval
E-value
PRK00509
PRK00509 argininosuccinate synthase; Provisional
12-403
0e+00
argininosuccinate synthase; Provisional
Pssm-ID: 234785
Cd Length: 399
Bit Score: 736.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSVII P WLKE N Y D CEV V AF V ADVGQG d EEL IG I E EKA KA SGASE C Y IA DL K EE M V A DY IY P TLKTG A Y YEGKY 91
Cdd:PRK00509 8 AYSGGLDTSVII K WLKE T Y G CEV I AF T ADVGQG - EEL EP I R EKA LK SGASE I Y VE DL R EE F V R DY VF P AIRAN A L YEGKY 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 L LGT SM ARP I IAK AQ VE V ARK V GADA LC HGCTGKGNDQVRFE GAF AALAPDL H VIAPWREWDL V SREE CLD Y LA E RN IP C 171
Cdd:PRK00509 87 P LGT AL ARP L IAK KL VE I ARK E GADA VA HGCTGKGNDQVRFE LGI AALAPDL K VIAPWREWDL K SREE LIA Y AE E HG IP I 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 TASLTKI YS R DAN A WH I S T EGG V LE NT WN A P N ED CWA WTV D PE Q AP N E S E T V TLKV EKG EV VA VD GE TMT P YNALVY LNE 251
Cdd:PRK00509 167 PVTKKSP YS I DAN L WH R S I EGG I LE DP WN E P P ED VYE WTV S PE D AP D E P E Y V EIEF EKG VP VA IN GE ALS P AELIEE LNE 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 KGA KHG V GRIDIVENRLVG M KSRG C YETPGGTI MME A L RA V E Q L V LD KAAFE F RE EL GV K ASH LVY D G R WF T PL CKSIL A 331
Cdd:PRK00509 247 LAG KHG I GRIDIVENRLVG I KSRG V YETPGGTI LIK A H RA L E S L T LD REVAH F KD EL EP K YAE LVY N G L WF S PL REALQ A 326
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515628537 332 ATE E LAQD V N GEV VI KLYKG H A T V TQKR S D NSLY S E EF AT FG ED E VYDQ SH AEGFI R L YS L S S R I R AL NSQ K 403
Cdd:PRK00509 327 FID E TQEH V T GEV RL KLYKG N A I V VGRK S P NSLY D E DL AT YE ED D VYDQ KD AEGFI K L WG L P S K I A AL VNK K 398
Name
Accession
Description
Interval
E-value
PRK00509
PRK00509 argininosuccinate synthase; Provisional
12-403
0e+00
argininosuccinate synthase; Provisional
Pssm-ID: 234785
Cd Length: 399
Bit Score: 736.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSVII P WLKE N Y D CEV V AF V ADVGQG d EEL IG I E EKA KA SGASE C Y IA DL K EE M V A DY IY P TLKTG A Y YEGKY 91
Cdd:PRK00509 8 AYSGGLDTSVII K WLKE T Y G CEV I AF T ADVGQG - EEL EP I R EKA LK SGASE I Y VE DL R EE F V R DY VF P AIRAN A L YEGKY 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 L LGT SM ARP I IAK AQ VE V ARK V GADA LC HGCTGKGNDQVRFE GAF AALAPDL H VIAPWREWDL V SREE CLD Y LA E RN IP C 171
Cdd:PRK00509 87 P LGT AL ARP L IAK KL VE I ARK E GADA VA HGCTGKGNDQVRFE LGI AALAPDL K VIAPWREWDL K SREE LIA Y AE E HG IP I 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 TASLTKI YS R DAN A WH I S T EGG V LE NT WN A P N ED CWA WTV D PE Q AP N E S E T V TLKV EKG EV VA VD GE TMT P YNALVY LNE 251
Cdd:PRK00509 167 PVTKKSP YS I DAN L WH R S I EGG I LE DP WN E P P ED VYE WTV S PE D AP D E P E Y V EIEF EKG VP VA IN GE ALS P AELIEE LNE 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 KGA KHG V GRIDIVENRLVG M KSRG C YETPGGTI MME A L RA V E Q L V LD KAAFE F RE EL GV K ASH LVY D G R WF T PL CKSIL A 331
Cdd:PRK00509 247 LAG KHG I GRIDIVENRLVG I KSRG V YETPGGTI LIK A H RA L E S L T LD REVAH F KD EL EP K YAE LVY N G L WF S PL REALQ A 326
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515628537 332 ATE E LAQD V N GEV VI KLYKG H A T V TQKR S D NSLY S E EF AT FG ED E VYDQ SH AEGFI R L YS L S S R I R AL NSQ K 403
Cdd:PRK00509 327 FID E TQEH V T GEV RL KLYKG N A I V VGRK S P NSLY D E DL AT YE ED D VYDQ KD AEGFI K L WG L P S K I A AL VNK K 398
ArgG
COG0137 Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ...
12-403
0e+00
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907
Cd Length: 397
Bit Score: 685.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSVIIPWLKE N Y DC EV V A FV ADVGQG d E E L IG IEEKA KAS GAS EC Y IA D LK EE M V A DY IY P TL K TG A Y YEGKY 91
Cdd:COG0137 6 AYSGGLDTSVIIPWLKE K Y GY EV I A VT ADVGQG - E D L EA IEEKA LKL GAS KA Y VV D AR EE F V E DY VF P AI K AN A L YEGKY 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 L LGT SM ARP I IAK AQ VE V AR KV GADA LC HGCTGKGNDQVRFE G A FA ALAPDL HV IAPWREWDL V SREE CLD Y LA E RN IP C 171
Cdd:COG0137 85 P LGT AL ARP L IAK KL VE I AR EE GADA VA HGCTGKGNDQVRFE L A IR ALAPDL KI IAPWREWDL K SREE EIE Y AE E HG IP V 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 T A SLT K I YS R D A N A W HI S T EGG V LE NT WN A P N ED CWA WTV D PE Q AP N E S E T VT LKV EKG EV VA VD GE TMT P YNALVY LNE 251
Cdd:COG0137 165 P A TKE K P YS I D E N L W GR S I EGG E LE DP WN E P P ED AYE WTV S PE D AP D E P E Y VT ITF EKG VP VA LN GE KLS P VELIEE LNE 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 K G A KHGVGRIDIVENRLVG M KSRG C YE T PG G TI MME A L RA V E Q L V LD KAAFE F REE L GV K ASH LVY D G R WF T PL CKSIL A 331
Cdd:COG0137 245 I G G KHGVGRIDIVENRLVG I KSRG V YE A PG A TI LIT A H RA L E S L T LD RETLH F KDI L DQ K YAE LVY N G L WF S PL REALD A 324
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515628537 332 ATE E LAQD V N G E V VI KLYKG H ATV TQKR S DN SLY S E EF AT FG ED E V Y DQ SH AEGFI R L YS L SS R IR A LNSQ K 403
Cdd:COG0137 325 FID E TQKR V T G T V RL KLYKG N ATV VGRK S PY SLY D E DL AT YE ED D V F DQ KD AEGFI K L FG L PL R VA A RVRK K 396
ASS
cd01999 argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ...
12-393
0e+00
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503
Cd Length: 386
Bit Score: 586.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSVI IP WLKE N Y DC EV V AF V AD V GQGDEE l IG IEEKA KAS GA SEC Y IA DL K EE MVA DYI Y P TL K TG A Y YEG K Y 91
Cdd:cd01999 6 AYSGGLDTSVI LK WLKE E Y GY EV I AF T AD L GQGDEE - EE IEEKA LKL GA VKV Y VV DL R EE FAE DYI F P AI K AN A I YEG R Y 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 L LGT SM ARP I IAK AQ VEVAR KV GA D A LC HGCTGKGNDQVRFE G A FA ALAPDL H VIAPWR E W DLVS R E E CLD Y LAERN IP C 171
Cdd:cd01999 85 P LGT AL ARP L IAK KL VEVAR EE GA T A VA HGCTGKGNDQVRFE L A IK ALAPDL K VIAPWR D W NFLT R A E EIA Y AKKHG IP V 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 TASLT K I YS R D A N A W HI S T EGG V LE NT WN A P N ED CWA WTV D PE Q AP N E S E T VT LKV EKG EV VAV D GE TMT P YNALVY LNE 251
Cdd:cd01999 165 PVTKK K P YS I D E N L W GR S Y EGG D LE DP WN E P P ED AFE WTV S PE K AP D E P E Y VT IEF EKG VP VAV N GE KLD P VELIEK LNE 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 KGAK HGVGRIDIVENRLVG M KSRG C YE T PG G T IMME A L R AV E Q L V LD KAAFE F REELGV K ASH LVY D G R WF T PL CKSIL A 331
Cdd:cd01999 245 IAGR HGVGRIDIVENRLVG I KSRG V YE A PG A T LLIK A H R DL E D L T LD REVLH F KDIVSR K YAE LVY N G L WF D PL REALE A 324
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515628537 332 ATEELAQD V N GEV VI KLYKG HAT V TQKR S D NSLYSEE F AT FG E DEVY DQ SH AEGFI RLYS L S 393
Cdd:cd01999 325 FIDKTQER V T GEV RL KLYKG NVI V VGRE S P NSLYSEE L AT YE E GDGF DQ KD AEGFI KIHG L Q 386
Arginosuc_synth
pfam00764 Arginosuccinate synthase; This family contains a PP-loop motif.
12-396
1.86e-180
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148
Cd Length: 386
Bit Score: 507.27
E-value: 1.86e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSV I IPWLKE NYDC EV V A FVA DVGQG D E ELIGIE EKA KAS GA SEC Y IA D L KEE M V A DYI Y P TLKTG A Y YE GK Y 91
Cdd:pfam00764 3 AYSGGLDTSV C IPWLKE QGGY EV I A VAV DVGQG G E DIDEAR EKA LKL GA VKH Y VI D A KEE F V E DYI F P AIQAN A L YE DR Y 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 L LGT SM ARP I IAK AQ VE V A R K V GA D A LC HGCTGKGNDQVRFE GA F AA LAPDL H VIAP W R EWD L v S REE CLD Y LA E RN IP C 171
Cdd:pfam00764 83 P LGT AL ARP L IAK KL VE A A K K E GA S A VA HGCTGKGNDQVRFE VS F RS LAPDL K VIAP V R DPN L - T REE EIE Y AE E HG IP I 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 TASLTKI YS R D A N A W HI S T E G G V LE NT WNAP N ED CWA WT V DP EQ AP N E SET V TLKV EKG EV VA V DGE TMT P YNALVY LNE 251
Cdd:pfam00764 162 PVTKKSP YS I D E N L W GR S I E A G I LE DP WNAP P ED IYE WT K DP AK AP D E PDI V EIGF EKG VP VA L DGE PVS P LELIEK LNE 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 KGAK HGVGRIDIVE N RLVG M KSR GC YE T P GG T IMME A L R AV E Q L V L DKAAFE F REELGV K ASH LVYDG R WF T PL CKSIL A 331
Cdd:pfam00764 242 IAGA HGVGRIDIVE D RLVG I KSR EI YE A P AA T VLIT A H R DL E N L T L TREVLR F KRIVDQ K WAE LVYDG L WF S PL KEALD A 321
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515628537 332 ATEELAQD V N G E V VI KL Y KG H A T V TQK RS DN SLY S EE FATFG E DEVY DQ SH A E GFI RLYS L SSR I 396
Cdd:pfam00764 322 FIDKTQER V T G T V RV KL H KG S A I V LGR RS PY SLY D EE LVSYD E GDTF DQ TD A T GFI KIHG L QAK I 386
argG
TIGR00032 argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ...
12-396
4.79e-156
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987
Cd Length: 394
Bit Score: 445.31
E-value: 4.79e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSV IIP WL K E - N Y dc EV V A FV ADVGQ GD E ELIG I E EKA KAS GA SEC Y IA D LK EE M V A DY IYPTLKTG A Y YEG K 90
Cdd:TIGR00032 5 AYSGGLDTSV CLK WL R E k G Y -- EV I A YT ADVGQ PE E DIDA I P EKA LEY GA ENH Y TI D AR EE F V K DY GFAAIQAN A F YEG T 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 91 Y L L G T SM ARP I IAK AQ VE V A R K V GA D A LC HGCTGKGNDQ V RFE GAFAA L A PDL H VIAPWR EWDL v S REE CLD Y LAERN IP 170
Cdd:TIGR00032 83 Y P L S T AL ARP L IAK KL VE A A K K E GA N A VA HGCTGKGNDQ E RFE RSIRL L N PDL K VIAPWR DLNF - T REE EIE Y AIQCG IP 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 171 CTA S LT K I YS R D A N A W HI S T E G G V LE NTWNA P N ED CWA WT VD P EQ A - P N E S E T VT LKV E K G EV VA VD G ETMT P YNALVYL 249
Cdd:TIGR00032 162 YPM S KE K P YS I D E N L W GR S I E A G I LE DPSTE P P ED IYM WT KF P DE A t P D E P E V VT IDF E Q G VP VA LN G VSLD P VELILEA 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 250 NE KGA KHGVGRIDI V ENR LV G M KSR GC YE T PG GTIMME A L R AV E Q L V L DKAAF EF REELGVKA S H L V Y D G R WF T PL CKSI 329
Cdd:TIGR00032 242 NE IAG KHGVGRIDI I ENR II G L KSR EI YE A PG AALLII A H R DL E T L T L TRDVL EF KDIVEEQY S E L I Y Q G L WF D PL AEAL 321
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515628537 330 L A ATEELAQD V N G E V VI KL Y KG H A T V TQKR S DN SLY S EE FATFGE D E V Y D QSH A E GFI RLYS L SSRI 396
Cdd:TIGR00032 322 D A FIRKTQER V T G T V RV KL F KG N A I V IGRT S PY SLY D EE LVSMEK D D V F D PRD A I GFI TMRG L QIKD 388
Name
Accession
Description
Interval
E-value
PRK00509
PRK00509 argininosuccinate synthase; Provisional
12-403
0e+00
argininosuccinate synthase; Provisional
Pssm-ID: 234785
Cd Length: 399
Bit Score: 736.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSVII P WLKE N Y D CEV V AF V ADVGQG d EEL IG I E EKA KA SGASE C Y IA DL K EE M V A DY IY P TLKTG A Y YEGKY 91
Cdd:PRK00509 8 AYSGGLDTSVII K WLKE T Y G CEV I AF T ADVGQG - EEL EP I R EKA LK SGASE I Y VE DL R EE F V R DY VF P AIRAN A L YEGKY 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 L LGT SM ARP I IAK AQ VE V ARK V GADA LC HGCTGKGNDQVRFE GAF AALAPDL H VIAPWREWDL V SREE CLD Y LA E RN IP C 171
Cdd:PRK00509 87 P LGT AL ARP L IAK KL VE I ARK E GADA VA HGCTGKGNDQVRFE LGI AALAPDL K VIAPWREWDL K SREE LIA Y AE E HG IP I 166
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 TASLTKI YS R DAN A WH I S T EGG V LE NT WN A P N ED CWA WTV D PE Q AP N E S E T V TLKV EKG EV VA VD GE TMT P YNALVY LNE 251
Cdd:PRK00509 167 PVTKKSP YS I DAN L WH R S I EGG I LE DP WN E P P ED VYE WTV S PE D AP D E P E Y V EIEF EKG VP VA IN GE ALS P AELIEE LNE 246
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 KGA KHG V GRIDIVENRLVG M KSRG C YETPGGTI MME A L RA V E Q L V LD KAAFE F RE EL GV K ASH LVY D G R WF T PL CKSIL A 331
Cdd:PRK00509 247 LAG KHG I GRIDIVENRLVG I KSRG V YETPGGTI LIK A H RA L E S L T LD REVAH F KD EL EP K YAE LVY N G L WF S PL REALQ A 326
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515628537 332 ATE E LAQD V N GEV VI KLYKG H A T V TQKR S D NSLY S E EF AT FG ED E VYDQ SH AEGFI R L YS L S S R I R AL NSQ K 403
Cdd:PRK00509 327 FID E TQEH V T GEV RL KLYKG N A I V VGRK S P NSLY D E DL AT YE ED D VYDQ KD AEGFI K L WG L P S K I A AL VNK K 398
ArgG
COG0137 Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase ...
12-403
0e+00
Argininosuccinate synthase [Amino acid transport and metabolism]; Argininosuccinate synthase is part of the Pathway/BioSystem: Arginine biosynthesis
Pssm-ID: 439907
Cd Length: 397
Bit Score: 685.64
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSVIIPWLKE N Y DC EV V A FV ADVGQG d E E L IG IEEKA KAS GAS EC Y IA D LK EE M V A DY IY P TL K TG A Y YEGKY 91
Cdd:COG0137 6 AYSGGLDTSVIIPWLKE K Y GY EV I A VT ADVGQG - E D L EA IEEKA LKL GAS KA Y VV D AR EE F V E DY VF P AI K AN A L YEGKY 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 L LGT SM ARP I IAK AQ VE V AR KV GADA LC HGCTGKGNDQVRFE G A FA ALAPDL HV IAPWREWDL V SREE CLD Y LA E RN IP C 171
Cdd:COG0137 85 P LGT AL ARP L IAK KL VE I AR EE GADA VA HGCTGKGNDQVRFE L A IR ALAPDL KI IAPWREWDL K SREE EIE Y AE E HG IP V 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 T A SLT K I YS R D A N A W HI S T EGG V LE NT WN A P N ED CWA WTV D PE Q AP N E S E T VT LKV EKG EV VA VD GE TMT P YNALVY LNE 251
Cdd:COG0137 165 P A TKE K P YS I D E N L W GR S I EGG E LE DP WN E P P ED AYE WTV S PE D AP D E P E Y VT ITF EKG VP VA LN GE KLS P VELIEE LNE 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 K G A KHGVGRIDIVENRLVG M KSRG C YE T PG G TI MME A L RA V E Q L V LD KAAFE F REE L GV K ASH LVY D G R WF T PL CKSIL A 331
Cdd:COG0137 245 I G G KHGVGRIDIVENRLVG I KSRG V YE A PG A TI LIT A H RA L E S L T LD RETLH F KDI L DQ K YAE LVY N G L WF S PL REALD A 324
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515628537 332 ATE E LAQD V N G E V VI KLYKG H ATV TQKR S DN SLY S E EF AT FG ED E V Y DQ SH AEGFI R L YS L SS R IR A LNSQ K 403
Cdd:COG0137 325 FID E TQKR V T G T V RL KLYKG N ATV VGRK S PY SLY D E DL AT YE ED D V F DQ KD AEGFI K L FG L PL R VA A RVRK K 396
ASS
cd01999 argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle ...
12-393
0e+00
argininosuccinate_synthase (ASS); Argininosuccinate synthase (ASS; EC 6.3.4.5) is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate. In humans, a defect in the ASS gene causes citrullinemia, a genetic disease characterized by severe vomiting spells and mental retardation. ASS is a homotetrameric enzyme of about 400 amino-acid residues. An arginine residue seems to be important for the enzyme's catalytic mechanism. The sequences of ASS from various prokaryotes, archaeabacteria and eukaryotes show significant similarity.
Pssm-ID: 467503
Cd Length: 386
Bit Score: 586.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSVI IP WLKE N Y DC EV V AF V AD V GQGDEE l IG IEEKA KAS GA SEC Y IA DL K EE MVA DYI Y P TL K TG A Y YEG K Y 91
Cdd:cd01999 6 AYSGGLDTSVI LK WLKE E Y GY EV I AF T AD L GQGDEE - EE IEEKA LKL GA VKV Y VV DL R EE FAE DYI F P AI K AN A I YEG R Y 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 L LGT SM ARP I IAK AQ VEVAR KV GA D A LC HGCTGKGNDQVRFE G A FA ALAPDL H VIAPWR E W DLVS R E E CLD Y LAERN IP C 171
Cdd:cd01999 85 P LGT AL ARP L IAK KL VEVAR EE GA T A VA HGCTGKGNDQVRFE L A IK ALAPDL K VIAPWR D W NFLT R A E EIA Y AKKHG IP V 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 TASLT K I YS R D A N A W HI S T EGG V LE NT WN A P N ED CWA WTV D PE Q AP N E S E T VT LKV EKG EV VAV D GE TMT P YNALVY LNE 251
Cdd:cd01999 165 PVTKK K P YS I D E N L W GR S Y EGG D LE DP WN E P P ED AFE WTV S PE K AP D E P E Y VT IEF EKG VP VAV N GE KLD P VELIEK LNE 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 KGAK HGVGRIDIVENRLVG M KSRG C YE T PG G T IMME A L R AV E Q L V LD KAAFE F REELGV K ASH LVY D G R WF T PL CKSIL A 331
Cdd:cd01999 245 IAGR HGVGRIDIVENRLVG I KSRG V YE A PG A T LLIK A H R DL E D L T LD REVLH F KDIVSR K YAE LVY N G L WF D PL REALE A 324
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515628537 332 ATEELAQD V N GEV VI KLYKG HAT V TQKR S D NSLYSEE F AT FG E DEVY DQ SH AEGFI RLYS L S 393
Cdd:cd01999 325 FIDKTQER V T GEV RL KLYKG NVI V VGRE S P NSLYSEE L AT YE E GDGF DQ KD AEGFI KIHG L Q 386
PLN00200
PLN00200 argininosuccinate synthase; Provisional
12-403
0e+00
argininosuccinate synthase; Provisional
Pssm-ID: 177791
Cd Length: 404
Bit Score: 561.67
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSVI IP WL K ENY D CEVV A F V ADVGQG D EEL I G I E E KAKASGA SECYIA DL K EE M V A DYI Y P T L KTG A Y YEGKY 91
Cdd:PLN00200 11 AYSGGLDTSVI LK WL R ENY G CEVV C F T ADVGQG I EEL E G L E A KAKASGA KQLVVK DL R EE F V R DYI F P C L RAN A I YEGKY 90
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 LLGTSMARP I IAKA Q V EV A RK VGADA LC HG C TGKGNDQVRFE GA F A AL A P D L H V I APWREWD LVS RE ECLD Y LAER NIP C 171
Cdd:PLN00200 91 LLGTSMARP L IAKA M V DI A KE VGADA VA HG A TGKGNDQVRFE LT F F AL N P E L K V V APWREWD IKG RE DLIE Y AKKH NIP V 170
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 TASLTK IYSRD A N A WHIS T EG GV LE NTW N A P N ED CWAWT V D PE Q AP NES E TVTLKV EKG EV VA VD G E T MT P YNA L VY LNE 251
Cdd:PLN00200 171 PVTKKS IYSRD R N L WHIS Y EG DI LE DPA N E P K ED MFMMS V S PE A AP DQP E YIEIEF EKG LP VA IN G K T LS P ATL L TK LNE 250
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 K G A KHG V GRID I VENR L VGMKSRG C YETPGGTI MME A L R AV E Q L V LD KAAFEFREE L GV K ASH LVY D G R WF T P LCK S IL A 331
Cdd:PLN00200 251 I G G KHG I GRID M VENR F VGMKSRG V YETPGGTI LFA A H R EL E S L T LD RETMQVKDS L AL K YAE LVY N G F WF D P ERE S MD A 330
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515628537 332 AT E ELAQDVN G E V VI KLYKG HAT V TQKR S DN SLY SEEFAT F G E DE - V Y D Q SH A E GFIRLY S L SS R I RA LNSQ K 403
Cdd:PLN00200 331 FM E KITETTT G S V RL KLYKG NVS V AGRK S PY SLY RQDISS F E E GG g I Y N Q AD A A GFIRLY A L RL R T RA MLRK K 403
Arginosuc_synth
pfam00764 Arginosuccinate synthase; This family contains a PP-loop motif.
12-396
1.86e-180
Arginosuccinate synthase; This family contains a PP-loop motif.
Pssm-ID: 279148
Cd Length: 386
Bit Score: 507.27
E-value: 1.86e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSV I IPWLKE NYDC EV V A FVA DVGQG D E ELIGIE EKA KAS GA SEC Y IA D L KEE M V A DYI Y P TLKTG A Y YE GK Y 91
Cdd:pfam00764 3 AYSGGLDTSV C IPWLKE QGGY EV I A VAV DVGQG G E DIDEAR EKA LKL GA VKH Y VI D A KEE F V E DYI F P AIQAN A L YE DR Y 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 92 L LGT SM ARP I IAK AQ VE V A R K V GA D A LC HGCTGKGNDQVRFE GA F AA LAPDL H VIAP W R EWD L v S REE CLD Y LA E RN IP C 171
Cdd:pfam00764 83 P LGT AL ARP L IAK KL VE A A K K E GA S A VA HGCTGKGNDQVRFE VS F RS LAPDL K VIAP V R DPN L - T REE EIE Y AE E HG IP I 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 172 TASLTKI YS R D A N A W HI S T E G G V LE NT WNAP N ED CWA WT V DP EQ AP N E SET V TLKV EKG EV VA V DGE TMT P YNALVY LNE 251
Cdd:pfam00764 162 PVTKKSP YS I D E N L W GR S I E A G I LE DP WNAP P ED IYE WT K DP AK AP D E PDI V EIGF EKG VP VA L DGE PVS P LELIEK LNE 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 252 KGAK HGVGRIDIVE N RLVG M KSR GC YE T P GG T IMME A L R AV E Q L V L DKAAFE F REELGV K ASH LVYDG R WF T PL CKSIL A 331
Cdd:pfam00764 242 IAGA HGVGRIDIVE D RLVG I KSR EI YE A P AA T VLIT A H R DL E N L T L TREVLR F KRIVDQ K WAE LVYDG L WF S PL KEALD A 321
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515628537 332 ATEELAQD V N G E V VI KL Y KG H A T V TQK RS DN SLY S EE FATFG E DEVY DQ SH A E GFI RLYS L SSR I 396
Cdd:pfam00764 322 FIDKTQER V T G T V RV KL H KG S A I V LGR RS PY SLY D EE LVSYD E GDTF DQ TD A T GFI KIHG L QAK I 386
argG
TIGR00032 argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a ...
12-396
4.79e-156
argininosuccinate synthase; argG in bacteria, ARG1 in Saccharomyces cerevisiae. There is a very unusual clustering in the alignment, with a deep split between one cohort of E. coli, H. influenzae, and Streptomyces, and the other cohort of eukaryotes, archaea, and the rest of the eubacteria. [Amino acid biosynthesis, Glutamate family]
Pssm-ID: 199987
Cd Length: 394
Bit Score: 445.31
E-value: 4.79e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSV IIP WL K E - N Y dc EV V A FV ADVGQ GD E ELIG I E EKA KAS GA SEC Y IA D LK EE M V A DY IYPTLKTG A Y YEG K 90
Cdd:TIGR00032 5 AYSGGLDTSV CLK WL R E k G Y -- EV I A YT ADVGQ PE E DIDA I P EKA LEY GA ENH Y TI D AR EE F V K DY GFAAIQAN A F YEG T 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 91 Y L L G T SM ARP I IAK AQ VE V A R K V GA D A LC HGCTGKGNDQ V RFE GAFAA L A PDL H VIAPWR EWDL v S REE CLD Y LAERN IP 170
Cdd:TIGR00032 83 Y P L S T AL ARP L IAK KL VE A A K K E GA N A VA HGCTGKGNDQ E RFE RSIRL L N PDL K VIAPWR DLNF - T REE EIE Y AIQCG IP 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 171 CTA S LT K I YS R D A N A W HI S T E G G V LE NTWNA P N ED CWA WT VD P EQ A - P N E S E T VT LKV E K G EV VA VD G ETMT P YNALVYL 249
Cdd:TIGR00032 162 YPM S KE K P YS I D E N L W GR S I E A G I LE DPSTE P P ED IYM WT KF P DE A t P D E P E V VT IDF E Q G VP VA LN G VSLD P VELILEA 241
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 250 NE KGA KHGVGRIDI V ENR LV G M KSR GC YE T PG GTIMME A L R AV E Q L V L DKAAF EF REELGVKA S H L V Y D G R WF T PL CKSI 329
Cdd:TIGR00032 242 NE IAG KHGVGRIDI I ENR II G L KSR EI YE A PG AALLII A H R DL E T L T L TRDVL EF KDIVEEQY S E L I Y Q G L WF D PL AEAL 321
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515628537 330 L A ATEELAQD V N G E V VI KL Y KG H A T V TQKR S DN SLY S EE FATFGE D E V Y D QSH A E GFI RLYS L SSRI 396
Cdd:TIGR00032 322 D A FIRKTQER V T G T V RV KL F KG N A I V IGRT S PY SLY D EE LVSMEK D D V F D PRD A I GFI TMRG L QIKD 388
PRK13820
PRK13820 argininosuccinate synthase; Provisional
12-396
1.22e-144
argininosuccinate synthase; Provisional
Pssm-ID: 237521
Cd Length: 394
Bit Score: 416.64
E-value: 1.22e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 AYSGGLDTSV II P W LKE N Y DC - EV VAFVA DVGQ GD EE LIGI EEKAK AS G A s EC Y IA D L KEE MVA DYI Y P TL K TG A Y YEG k 90
Cdd:PRK13820 8 AYSGGLDTSV CV P L LKE K Y GY d EV ITVTV DVGQ PE EE IKEA EEKAK KL G D - KH Y TI D A KEE FAK DYI F P AI K AN A L YEG - 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 91 Y L LGT SM ARP I IA KAQ VEVA R K V GA D A LC HGCTGKGNDQ V RFE GA F aa L A P DL H VIAP W RE WD L v S RE ECLD Y LA E RN IP 170
Cdd:PRK13820 86 Y P LGT AL ARP L IA EKI VEVA E K E GA S A IA HGCTGKGNDQ L RFE AV F -- R A S DL E VIAP I RE LN L - T RE WEIE Y AK E KG IP 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 171 CTASLT K IY S R D A N A W HI S T EGG V LE NTWNA P N E DCW AWTV D PE Q AP N E S E T V TLKV E K G EV VA VD GE T M TPYNALVY LN 250
Cdd:PRK13820 163 VPVGKE K PW S I D E N L W SR S I EGG K LE DPAFE P P E EIY AWTV S PE D AP D E P E I V EIEF E E G VP VA IN GE K M DGVELIRK LN 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 251 E KGA KHGVGR I D IV E N R LV G M KSR GC YE T P GG T IMME A LR A V EQLVL DKAAFE F R E ELGV K ASH L V Y D G RWFT PL CKSIL 330
Cdd:PRK13820 243 E IAG KHGVGR T D MM E D R VL G L KSR EN YE H P AA T VLLT A HK A L EQLVL TREELK F K E IVDS K WAE L A Y E G LVDE PL REDLN 322
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515628537 331 A ATEELAQD V N G E V VI KLYKG H A T V TQKR S DNS LYSEE FAT F g EDEVY DQ SH AEG FIRLYS L SS R I 396
Cdd:PRK13820 323 A FIDKTQER V T G T V TV KLYKG S A R V VGRE S PYA LYSEE LVS F - DSKTI DQ RD AEG MAKYHG L QA R L 387
PRK04527
PRK04527 argininosuccinate synthase; Provisional
12-398
5.55e-69
argininosuccinate synthase; Provisional
Pssm-ID: 235305
Cd Length: 400
Bit Score: 223.17
E-value: 5.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 A Y SGGLDTS VI IP W L K E - N Y DCEV V a F VADV G QGD EE LIG IE EK A KAS GA SECYIA D LKEEMVADYIY P TLKT G AY Y E G K 90
Cdd:PRK04527 8 A F SGGLDTS FC IP Y L Q E r G Y AVHT V - F ADTG G VDA EE RDF IE KR A AEL GA ASHVTV D GGPAIWEGFVK P LVWA G EG Y Q G Q 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 91 Y L L GT S m A R PI I AK A QVEV A RKV G ADALC HGCTG K GNDQVRF EG A FA AL A p D LHVI AP W RE WDLV --- S R EECLD YL A ER 167
Cdd:PRK04527 87 Y P L LV S - D R YL I VD A ALKR A EEL G TRIIA HGCTG M GNDQVRF DL A VK AL G - D YQIV AP I RE IQKE htq T R AYEQK YL E ER 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 168 NIPCT A S l T K I Y SRDA N AWHISTE GG VLEN t W N AP N E DCWA W TVDPEQA P N E SE TVT L K VEK GE V VA V DG ETMTPYNA L V 247
Cdd:PRK04527 165 GFGVR A K - Q K A Y TINE N LLGVTMS GG EIDR - W E AP G E GARG W CAPRSAW P T E AL TVT I K FVE GE A VA L DG KPLPGAQI L A 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 248 Y LN EKG A KH GVGR IDIVENRLV G M K S R GCY E T PG GTIMME A L RA V E QL VL D K AAFE F REELGV K ASH LVY D G RWFT PL CK 327
Cdd:PRK04527 243 K LN KLF A QY GVGR GVYTGDTVI G L K G R IVF E A PG LVSLLT A H RA L E DA VL T K QQNR F KPDVAR K WVE LVY E G FYHD PL KT 322
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515628537 328 S I L A ATEELAQD VNGEV VIKLYK G HATVTQK RS DNS L Y S EE f AT FGEDEVYDQSH AEGFI R L YSL SS RIR A 398
Cdd:PRK04527 323 D I E A FLKSSQAK VNGEV TLETRG G RVDAVAV RS PHL L N S KG - AT YAQSADWGVEE AEGFI K L FGM SS TLY A 392
PRK05370
PRK05370 argininosuccinate synthase; Validated
12-368
1.12e-37
argininosuccinate synthase; Validated
Pssm-ID: 235434
Cd Length: 447
Bit Score: 141.27
E-value: 1.12e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 12 A Y SGGLDTS VIIP W LKEN y DCEVV A FV A DV GQ G DE ELI - G I EEK A KAS GA SECYIA D LKEEM VA DY I y PTLKT GA YY --- 87
Cdd:PRK05370 17 A F SGGLDTS AALL W MRQK - GAVPY A YT A NL GQ P DE DDY d A I PRR A MEY GA ENARLI D CRAQL VA EG I - AAIQC GA FH ist 94
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 88 E G K - Y LLG T SMA R PIIAKAQ V EVARKV G ADALCH G C T G KGND QV RF E g AFAA L A - P D L HVIA PW REW D LVS ---- R E E CL 161
Cdd:PRK05370 95 G G V t Y FNT T PLG R AVTGTML V AAMKED G VNIWGD G S T Y KGND IE RF Y - RYGL L T n P E L KIYK PW LDQ D FID elgg R A E MS 173
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 162 DY L AERNIPCTA S LT K I YS R D A N AWHIST E GGV LE NT wnapne DCWAWT V D P -------- E QAPNES E T VT LKV E K G EV V 233
Cdd:PRK05370 174 EF L IAHGFDYKM S VE K A YS T D S N MLGATH E AKD LE HL ------ NSGIKI V N P imgvafwd E DVEIKA E E VT VRF E Q G RP V 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515628537 234 A VD G E T MT - P YNALVYL N EK G AK HG V G RI D IV ENR LVGM KSRG C YE T PG gtim M EA L R - A V E Q LV L ----- D KAA f EF R E 306
Cdd:PRK05370 248 A LN G K T FS d P VELMLEA N RI G GR HG L G MS D QI ENR IIEA KSRG I YE A PG ---- M AL L H i A Y E R LV T gihne D TIE - QY R I 322
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515628537 307 E l G VKASH L V Y D GRWF T P lc KSIL --- AATEEL A QDVN GEV VIK L YK G HA - TVTQKR S D N SL Y SE E 368
Cdd:PRK05370 323 N - G RRLGR L L Y Q GRWF D P -- QALM lre SLQRWV A SAIT GEV TLE L RR G ND y SILNTV S P N LT Y KP E 385
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
