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Conserved domains on  [gi|515629547|ref|WP_017062147|]
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MULTISPECIES: DNA polymerase III subunit delta' [Vibrio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06090 super family cl32112
DNA polymerase III subunit delta'; Validated
 1-321 0e+00

DNA polymerase III subunit delta'; Validated


The actual alignment was detected with superfamily member PRK06090:

Pssm-ID: 180394 [Multi-domain]  Cd Length: 319  Bit Score: 522.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   1 MAEVYSWLTPVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYESESCGFCHSCELMKSGSHPDFHVIS 80
Cdd:PRK06090   1 MNNDYPWLVPVWQNWKAGLDAGRIPGALLLQSDEGLGVESLVELFSRALLCQNYQSEACGFCHSCELMQSGNHPDLHVIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  81 PEKEGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQ 160
Cdd:PRK06090  81 PEKEGKSITVEQIRQCNRLAQESSQLNGYRLFVIEPADAMNESASNALLKTLEEPAPNCLFLLVTHNQKRLLPTIVSRCQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 161 QFNVVSPQLETASAWLDGEVGKaVPQYILALNDNAPLKAKAMFEQGGVEASTKALDGFVNVIKGTQPDMLKFSTELSKDP 240
Cdd:PRK06090 161 QWVVTPPSTAQAMQWLKGQGIT-VPAYALKLNMGSPLKTLAMMKEGGLEKYHKLERQLVDALSGPVSDQLKCASLIAADP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 241 LIQLGWLWHLLSDVQKLHFGLANQAFTPSAKALcEAMSYQSAYAASNKLLTLIEQLKQHPGLNTELLIMNWLIATCEETC 320
Cdd:PRK06090 240 LTHLSWLWLLLTDAQKVHFGVQNEYYLPGSAAL-GPFTYSGLYVSTAKLERLKEQLQQFSGLNTELLIMNWLIESREELC 318


                 .
gi 515629547 321 S 321
Cdd:PRK06090 319 L 319
 
Name Accession Description Interval E-value
PRK06090 PRK06090
DNA polymerase III subunit delta'; Validated
 1-321 0e+00

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180394 [Multi-domain]  Cd Length: 319  Bit Score: 522.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   1 MAEVYSWLTPVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYESESCGFCHSCELMKSGSHPDFHVIS 80
Cdd:PRK06090   1 MNNDYPWLVPVWQNWKAGLDAGRIPGALLLQSDEGLGVESLVELFSRALLCQNYQSEACGFCHSCELMQSGNHPDLHVIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  81 PEKEGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQ 160
Cdd:PRK06090  81 PEKEGKSITVEQIRQCNRLAQESSQLNGYRLFVIEPADAMNESASNALLKTLEEPAPNCLFLLVTHNQKRLLPTIVSRCQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 161 QFNVVSPQLETASAWLDGEVGKaVPQYILALNDNAPLKAKAMFEQGGVEASTKALDGFVNVIKGTQPDMLKFSTELSKDP 240
Cdd:PRK06090 161 QWVVTPPSTAQAMQWLKGQGIT-VPAYALKLNMGSPLKTLAMMKEGGLEKYHKLERQLVDALSGPVSDQLKCASLIAADP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 241 LIQLGWLWHLLSDVQKLHFGLANQAFTPSAKALcEAMSYQSAYAASNKLLTLIEQLKQHPGLNTELLIMNWLIATCEETC 320
Cdd:PRK06090 240 LTHLSWLWLLLTDAQKVHFGVQNEYYLPGSAAL-GPFTYSGLYVSTAKLERLKEQLQQFSGLNTELLIMNWLIESREELC 318


                 .
gi 515629547 321 S 321
Cdd:PRK06090 319 L 319
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
8-296 1.36e-74

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 231.02  E-value: 1.36e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   8 LTPVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYE-SESCGFCHScELMKSGSHPDFHVISPEKEGK 86
Cdd:COG0470    1 QEEAWEQLLAAAESGRLPHALLLHGPPGIGKTTLALALARDLLCENPEgGKACGQCHS-RLMAAGNHPDLLELNPEEKSD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  87 SITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVS 166
Cdd:COG0470   80 QIGIDQIRELGEFLSLTPLEGGRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLPTIRSRCQVIRFRP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 167 PQLETASAWLDGE-VGKAVPQYILALNDNAPLKAKAMFEQGgveASTKALDGFVNVIkGTQPDMLKFSTELSKDPLIQ-L 244
Cdd:COG0470  160 PSEEEALAWLREEgVDEDALEAILRLAGGDPRAAINLLQAL---AGRKELLEDLAAL-LSRDRALELLDALLKAEALElL 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 515629547 245 GWLWHLLSDVqkLHFGLANQAFTPSAKALCEAMSYQSAYAasNKLLTLIEQL 296
Cdd:COG0470  236 DWLLKWLLDN--LPLEYAGEDLARAYEALSEADRRLGRYA--NDRLLLEALL 283
holB TIGR00678
DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' ...
 12-199 1.46e-65

DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits. At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273213 [Multi-domain]  Cd Length: 188  Bit Score: 204.40  E-value: 1.46e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   12 WSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTN-YESESCGFCHSCELMKSGSHPDFHVISPEkeGKSITV 90
Cdd:TIGR00678   1 YQQLKRALEKGRLAHAYLFTGPEGVGKELLALALAKALLCEQrGGGEPCGECHSCRLIEAGNHPDLHRLEPE--GQSIKV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   91 DQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVSPQLE 170
Cdd:TIGR00678  79 DQVRELVEFLSRTPQESGRRVVIIEDAERMNEAAANALLKTLEEPPPNTLFILITPSPEKLLPTIRSRCQRLPFPPLSEE 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 515629547  171 TASAWLDGE-VGKAVPQYILALNDNAPLKA 199
Cdd:TIGR00678 159 ALLQWLIRQgISEEAAELLLALAGGSPGRA 188
DNA_pol3_delta2 pfam13177
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
 7-163 1.22e-46

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 433013 [Multi-domain]  Cd Length: 161  Bit Score: 155.06  E-value: 1.22e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547    7 WLTPVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYES-ESCGFCHSCELMKSGSHPDFHVISPEkeG 85
Cdd:pfam13177   1 GQPEAIQLLQNSLENGRLSHAYLFSGPEGVGKLELALAFAKALFCEEPGDdLPCGQCRSCRRIESGNHPDLVIIEPE--G 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629547   86 KSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:pfam13177  79 QSIKIDQIRELQKEFSKSPYEGKKKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPTIRSRCQIIR 156
 
Name Accession Description Interval E-value
PRK06090 PRK06090
DNA polymerase III subunit delta'; Validated
 1-321 0e+00

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180394 [Multi-domain]  Cd Length: 319  Bit Score: 522.44  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   1 MAEVYSWLTPVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYESESCGFCHSCELMKSGSHPDFHVIS 80
Cdd:PRK06090   1 MNNDYPWLVPVWQNWKAGLDAGRIPGALLLQSDEGLGVESLVELFSRALLCQNYQSEACGFCHSCELMQSGNHPDLHVIK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  81 PEKEGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQ 160
Cdd:PRK06090  81 PEKEGKSITVEQIRQCNRLAQESSQLNGYRLFVIEPADAMNESASNALLKTLEEPAPNCLFLLVTHNQKRLLPTIVSRCQ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 161 QFNVVSPQLETASAWLDGEVGKaVPQYILALNDNAPLKAKAMFEQGGVEASTKALDGFVNVIKGTQPDMLKFSTELSKDP 240
Cdd:PRK06090 161 QWVVTPPSTAQAMQWLKGQGIT-VPAYALKLNMGSPLKTLAMMKEGGLEKYHKLERQLVDALSGPVSDQLKCASLIAADP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 241 LIQLGWLWHLLSDVQKLHFGLANQAFTPSAKALcEAMSYQSAYAASNKLLTLIEQLKQHPGLNTELLIMNWLIATCEETC 320
Cdd:PRK06090 240 LTHLSWLWLLLTDAQKVHFGVQNEYYLPGSAAL-GPFTYSGLYVSTAKLERLKEQLQQFSGLNTELLIMNWLIESREELC 318


                 .
gi 515629547 321 S 321
Cdd:PRK06090 319 L 319
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
8-296 1.36e-74

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 231.02  E-value: 1.36e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   8 LTPVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYE-SESCGFCHScELMKSGSHPDFHVISPEKEGK 86
Cdd:COG0470    1 QEEAWEQLLAAAESGRLPHALLLHGPPGIGKTTLALALARDLLCENPEgGKACGQCHS-RLMAAGNHPDLLELNPEEKSD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  87 SITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVS 166
Cdd:COG0470   80 QIGIDQIRELGEFLSLTPLEGGRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLPTIRSRCQVIRFRP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 167 PQLETASAWLDGE-VGKAVPQYILALNDNAPLKAKAMFEQGgveASTKALDGFVNVIkGTQPDMLKFSTELSKDPLIQ-L 244
Cdd:COG0470  160 PSEEEALAWLREEgVDEDALEAILRLAGGDPRAAINLLQAL---AGRKELLEDLAAL-LSRDRALELLDALLKAEALElL 235

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 515629547 245 GWLWHLLSDVqkLHFGLANQAFTPSAKALCEAMSYQSAYAasNKLLTLIEQL 296
Cdd:COG0470  236 DWLLKWLLDN--LPLEYAGEDLARAYEALSEADRRLGRYA--NDRLLLEALL 283
holB TIGR00678
DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' ...
 12-199 1.46e-65

DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits. At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273213 [Multi-domain]  Cd Length: 188  Bit Score: 204.40  E-value: 1.46e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   12 WSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTN-YESESCGFCHSCELMKSGSHPDFHVISPEkeGKSITV 90
Cdd:TIGR00678   1 YQQLKRALEKGRLAHAYLFTGPEGVGKELLALALAKALLCEQrGGGEPCGECHSCRLIEAGNHPDLHRLEPE--GQSIKV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   91 DQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVSPQLE 170
Cdd:TIGR00678  79 DQVRELVEFLSRTPQESGRRVVIIEDAERMNEAAANALLKTLEEPPPNTLFILITPSPEKLLPTIRSRCQRLPFPPLSEE 158

                         170       180       190
                  ....*....|....*....|....*....|
gi 515629547  171 TASAWLDGE-VGKAVPQYILALNDNAPLKA 199
Cdd:TIGR00678 159 ALLQWLIRQgISEEAAELLLALAGGSPGRA 188
PRK05707 PRK05707
DNA polymerase III subunit delta'; Validated
 1-313 1.86e-63

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180215 [Multi-domain]  Cd Length: 328  Bit Score: 203.78  E-value: 1.86e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   1 MAEVYSWLTPVWSEwkkSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYES-ESCGFCHSCELMKSGSHPDFHVI 79
Cdd:PRK05707   1 MAEIYPWQQSLWQQ---LAGRGRHPHAYLLHGPAGIGKRALAERLAAALLCEAPQGgGACGSCKGCQLLRAGSHPDNFVL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  80 SPEKEGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRC 159
Cdd:PRK05707  78 EPEEADKTIKVDQVRELVSFVVQTAQLGGRKVVLIEPAEAMNRNAANALLKSLEEPSGDTVLLLISHQPSRLLPTIKSRC 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 160 QQFNVVSPQLETASAWLD---GEVGKAVPQYILALNDNAPLKAKAMFEQGGVEASTKALDGFVNVIKGTQpDMLKFSTEL 236
Cdd:PRK05707 158 QQQACPLPSNEESLQWLQqalPESDERERIELLTLAGGSPLRALQLHEQGVREQRARVLDGVKKLLKQQQ-SASQLAESW 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 237 SKDPLIQL-GWLWHLLSDVQKLHF-----GLANQAFTPSAKALCEAMSYQSAYAASNKLLTLIEQLKQHPGLNTELLIMN 310
Cdd:PRK05707 237 LKVPLLLLfDWFCDWAHDILRYQLtqdeeGLGLADMRKVLQYLAQKSPQAKVLALQDWLLEQRQKVLGKANLNRQLLLEA 316


                 ...
gi 515629547 311 WLI 313
Cdd:PRK05707 317 LLV 319
PRK06871 PRK06871
DNA polymerase III subunit delta'; Validated
 4-312 3.72e-60

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180738 [Multi-domain]  Cd Length: 325  Bit Score: 195.34  E-value: 3.72e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   4 VYSWLTPVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMC-TNYESESCGFCHSCELMKSGSHPDFHVISPe 82
Cdd:PRK06871   3 LYPWLQPTYQQITQAFQQGLGHHALLFKADSGLGTEQLIRALAQWLMCqTPQGDQPCGQCHSCHLFQAGNHPDFHILEP- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  83 KEGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK06871  82 IDNKDIGVDQVREINEKVSQHAQQGGNKVVYIQGAERLTEAAANALLKTLEEPRPNTYFLLQADLSAALLPTIYSRCQTW 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 163 NVVSPQLETASAWLDGEVGKAVP--QYILALNDNAPLKAKAMFEQGGVEASTKALDGFVNVIKGTQPDML--KFSTELSk 238
Cdd:PRK06871 162 LIHPPEEQQALDWLQAQSSAEISeiLTALRINYGRPLLALTFLEQGLLEQRKTFLRQFWLFYRRRSPLELlpLFDKELV- 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629547 239 dpLIQLGWLWHLLSDVQKLHFGLANQAFTPSAKALCEAMSYQSAYAASNKLLTLIEQ----LKQHPGLNTELLIMNWL 312
Cdd:PRK06871 241 --LQQLDWLLAFLSDALKAKLDIASGWICQDLQRGILQFSQQQSAQGLLKAHQIIQKvrsdLLQINAVNQELILLDGL 316
PRK07993 PRK07993
DNA polymerase III subunit delta'; Validated
 5-311 8.30e-54

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181190 [Multi-domain]  Cd Length: 334  Bit Score: 179.11  E-value: 8.30e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   5 YSWLTPVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYESE-SCGFCHSCELMKSGSHPDFHVISPEK 83
Cdd:PRK07993   4 YPWLRPDYEQLVGSYQAGRGHHALLIQALPGMGDDALIYALSRWLMCQQPQGHkSCGHCRGCQLMQAGTHPDYYTLTPEK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  84 EGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK07993  84 GKSSLGVDAVREVTEKLYEHARLGGAKVVWLPDAALLTDAAANALLKTLEEPPENTWFFLACREPARLLATLRSRCRLHY 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 164 VVSPQLETASAWLDGEVgKAVPQYILA---LNDNAPLKAKAMFeQGGVEASTKAL-DGFVNVIkgTQPDMLKFSTELSKD 239
Cdd:PRK07993 164 LAPPPEQYALTWLSREV-TMSQDALLAalrLSAGAPGAALALL-QPERWQQREALcQALAYAL--PSGDWLSLLPALNHE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 240 PLIQ-LGWLWHLLSDVQKLHFG---LANQAFTPSAKALCEAMSYQSAYAASNKLLTLIEQLKQHPGLNTELL----IMNW 311
Cdd:PRK07993 240 QAPArLHWLATLLMDALKRQHGaayVTNQDQPPLVAQLANHLSPARLQAILGDVCHCREQLLSVTGVNRELLltdlLLRI 319
PRK06964 PRK06964
DNA polymerase III subunit delta'; Validated
 4-308 9.53e-50

DNA polymerase III subunit delta'; Validated


Pssm-ID: 235898 [Multi-domain]  Cd Length: 342  Bit Score: 168.79  E-value: 9.53e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   4 VYSWLTPVWSEWKKSldAERFPNSVIVNAPEGLGVDALISQLTDALMCT--NYESESCGFCHSCELMKSGSHPDFHVISP 81
Cdd:PRK06964   2 LYPWQTDDWNRLQAL--RARLPHALLLHGQAGIGKLDFAQHLAQGLLCEtpQPDGEPCGTCAACNWFAQGNHPDYRIVRP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  82 E-------------------KEGKS-------ITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEP 135
Cdd:PRK06964  80 EalaaeapgaadeakeadadEGGKKtkapskeIKIEQVRALLDFCGVGTHRGGARVVVLYPAEALNVAAANALLKTLEEP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 136 SSKCIFILSTRNSNRLMPTIISRCQQFNVVSPQLETASAWLDGEvGKAVPQYILALNDNAPLKAKAMFEQGGVEastkAL 215
Cdd:PRK06964 160 PPGTVFLLVSARIDRLLPTILSRCRQFPMTVPAPEAAAAWLAAQ-GVADADALLAEAGGAPLAALALASDENRP----LR 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 216 DGFVNVI-KGTQPDMLKFSTELSKDPL-IQLGWLWHLLSDVQKLHFGLANQAFTPSAKAL--CEAMSYQSAYAASNKLLT 291
Cdd:PRK06964 235 DWTLGQLaAGAACDAFACAETLQKLPVpAVLGWLQRWLYDLLAQRLAGAPRYFPAQRAALarCAAAVDANALARFAKAVT 314

                        330
                 ....*....|....*..
gi 515629547 292 LIEQLKQHPgLNTELLI 308
Cdd:PRK06964 315 RQRAVENHP-LAARLVF 330
DNA_pol3_delta2 pfam13177
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
 7-163 1.22e-46

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 433013 [Multi-domain]  Cd Length: 161  Bit Score: 155.06  E-value: 1.22e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547    7 WLTPVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYES-ESCGFCHSCELMKSGSHPDFHVISPEkeG 85
Cdd:pfam13177   1 GQPEAIQLLQNSLENGRLSHAYLFSGPEGVGKLELALAFAKALFCEEPGDdLPCGQCRSCRRIESGNHPDLVIIEPE--G 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629547   86 KSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:pfam13177  79 QSIKIDQIRELQKEFSKSPYEGKKKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPTIRSRCQIIR 156
PRK08699 PRK08699
DNA polymerase III subunit delta'; Validated
 4-254 1.92e-44

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181538 [Multi-domain]  Cd Length: 325  Bit Score: 154.26  E-value: 1.92e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   4 VYSWLTPVWSEWkkSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTN--YESESCGFCHSCELMKSGSHPDFHVISP 81
Cdd:PRK08699   2 IYPWHQEQWRQI--AEHWERRPNAWLFAGKKGIGKTAFARFAAQALLCETpaPGHKPCGECMSCHLFGQGSHPDFYEITP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  82 ----EKEGK---SITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPT 154
Cdd:PRK08699  80 lsdePENGRkllQIKIDAVREIIDNVYLTSVRGGLRVILIHPAESMNLQAANSLLKVLEEPPPQVVFLLVSHAADKVLPT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 155 IISRCQQFNVVSPQLETASAWLDgEVGKAVPQYILALNDNAPLkakAMFEQGGVEASTKALDGFvnvikgTQPD---MLK 231
Cdd:PRK08699 160 IKSRCRKMVLPAPSHEEALAYLR-ERGVAEPEERLAFHSGAPL---FDEEPELRALRIKLLDIL------AEPRllkILD 229

                        250       260
                 ....*....|....*....|....*.
gi 515629547 232 FSTELSKD--PLIQ-LGWLWHLLSDV 254
Cdd:PRK08699 230 YAALFDKEklPLAVfVGWMQKWLVDL 255
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
48-312 3.65e-42

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 148.80  E-value: 3.65e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  48 ALMCTNYES-ESCGFCHSCELMKSGSHPDFHVISPEkeGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASN 126
Cdd:COG2812   55 ALNCENGPTgEPCGECESCRAIAAGSHPDVIEIDAE--ASNIGVDDIRELIEKVSYAPVEGRYKVYIIDEAHMLTTEAFN 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 127 ALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVSPQLETASAWL-------DGEVGKAVPQYILALNDNAPLKA 199
Cdd:COG2812  133 ALLKTLEEPPPHVVFILATTEPQKLLPTILSRCQRFDFRRLPPEEIAEHLakiaereGIEIEPEALALIARAADGSMRDA 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 200 KAMFEQ----GGVEASTKALDGFVNVIKGTQPDMLKFSTELS---KDPLIQLGWLWHLLSDVQKLHFG-----LANQAFT 267
Cdd:COG2812  213 LSLLDQaiafGLLDRRELLLDLLEALLAGDVAALLALAEELAkrgRDLKRFLDDLLSLLRDLLLLKLGpdaelLVNEDER 292

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 515629547 268 PSAKALCEAMSYQSAYAASNKLLTLIEQLKQ--HPGLNTELLIMNWL 312
Cdd:COG2812  293 ERLQELARRLSPERLLRAIQILLEARRELERnvNPRLALEMLLLRLA 339
PRK07940 PRK07940
DNA polymerase III subunit delta'; Validated
 48-176 1.35e-29

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236134 [Multi-domain]  Cd Length: 394  Bit Score: 116.16  E-value: 1.35e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  48 ALMCTNYESESCGFCHSCELMKSGSHPDFHVISPEkeGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNA 127
Cdd:PRK07940  59 ALQCTDPDEPGCGECRACRTVLAGTHPDVRVVAPE--GLSIGVDEVRELVTIAARRPSTGRWRIVVIEDADRLTERAANA 136

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 515629547 128 LLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVSPQLETASAWL 176
Cdd:PRK07940 137 LLKAVEEPPPRTVWLLCAPSPEDVLPTIRSRCRHVALRTPSVEAVAEVL 185
PRK08769 PRK08769
DNA polymerase III subunit delta'; Validated
 8-176 9.53e-27

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181551 [Multi-domain]  Cd Length: 319  Bit Score: 107.35  E-value: 9.53e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   8 LTPVWSEWKK--------SLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYESESCGFCHscELMKSGSHPDFHVI 79
Cdd:PRK08769   1 MTSAFSPWQQraydqtvaALDAGRLGHGLLICGPEGLGKRAVALALAEHVLASGPDPAAAQRTR--QLIAAGTHPDLQLV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  80 S--PEKEG----KSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMP 153
Cdd:PRK08769  79 SfiPNRTGdklrTEIVIEQVREISQKLALTPQYGIAQVVIVDPADAINRAACNALLKTLEEPSPGRYLWLISAQPARLPA 158

                        170       180
                 ....*....|....*....|...
gi 515629547 154 TIISRCQQFNVVSPQLETASAWL 176
Cdd:PRK08769 159 TIRSRCQRLEFKLPPAHEALAWL 181
PRK08058 PRK08058
DNA polymerase III subunit delta'; Validated
 16-161 2.06e-26

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181214 [Multi-domain]  Cd Length: 329  Bit Score: 106.55  E-value: 2.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNY-ESESCGFCHSCELMKSGSHPDFHVISPEkeGKSITVDQVR 94
Cdd:PRK08058  19 QNSIAKNRLSHAYLFEGAKGTGKKATALWLAKSLFCLERnGVEPCGTCTNCKRIDSGNHPDVHLVAPD--GQSIKKDQIR 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515629547  95 A-----SNRwAQESSQlgglRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQ 161
Cdd:PRK08058  97 YlkeefSKS-GVESNK----KVYIIEHADKMTASAANSLLKFLEEPSGGTTAILLTENKHQILPTILSRCQV 163
PRK09112 PRK09112
DNA polymerase III subunit delta'; Validated
 70-231 1.24e-25

DNA polymerase III subunit delta'; Validated


Pssm-ID: 169667 [Multi-domain]  Cd Length: 351  Bit Score: 104.73  E-value: 1.24e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  70 SGSHPD-FHVISP--EKEGK---SITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFIL 143
Cdd:PRK09112  97 QGAHPNlLHITRPfdEKTGKfktAITVDEIRRVGHFLSQTSGDGNWRIVIIDPADDMNRNAANAILKTLEEPPARALFIL 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 144 STRNSNRLMPTIISRCQQ--FNVVSPQ-LETASAWL------DGEVGKAvpqyILALNDNAPLKAKAMFEQGGVEAStKA 214
Cdd:PRK09112 177 ISHSSGRLLPTIRSRCQPisLKPLDDDeLKKALSHLgssqgsDGEITEA----LLQRSKGSVRKALLLLNYGGLEII-AT 251

                        170
                 ....*....|....*..
gi 515629547 215 LDgfvNVIKGTQPDMLK 231
Cdd:PRK09112 252 ID---QLLAGSGPDARK 265
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
 16-162 7.80e-25

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 104.15  E-value: 7.80e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYESESCGFCHSCELMKSGSHPDFHVISPEKEGksiTVDQVRA 95
Cdd:PRK14963  27 LAALRQGRLGHAYLFSGPRGVGKTTTARLIAMAVNCSGEDPKPCGECESCLAVRRGAHPDVLEIDAASNN---SVEDVRD 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515629547  96 SNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK14963 104 LREKVLLAPLRGGRKVYILDEAHMMSKSAFNALLKTLEEPPEHVIFILATTEPEKMPPTILSRTQHF 170
PRK07399 PRK07399
DNA polymerase III subunit delta'; Validated
 16-161 4.41e-22

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236011 [Multi-domain]  Cd Length: 314  Bit Score: 94.20  E-value: 4.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGvDALIS-QLTDALMCtnyeSESCGFCHSCELmKSGSHPDFHVISP------------- 81
Cdd:PRK07399  17 TAAIKQNRIAPAYLFAGPEGVG-RKLAAlCFIEGLLS----QGSPSKNIRRRL-EEGNHPDLLWVEPtyqhqgklitase 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  82 -EKEGKS------ITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPsSKCIFILSTRNSNRLMPT 154
Cdd:PRK07399  91 aEEAGLKrkappqIRLEQIREIKRFLSRPPLEAPRKVVVIEDAETMNEAAANALLKTLEEP-GNGTLILIAPSPESLLPT 169


                 ....*..
gi 515629547 155 IISRCQQ 161
Cdd:PRK07399 170 IVSRCQI 176
DNApol3-delta_C pfam09115
DNA polymerase III, delta subunit, C terminal; Members of this family, which are predominantly ...
 209-313 1.69e-21

DNA polymerase III, delta subunit, C terminal; Members of this family, which are predominantly found in prokaryotic DNA polymerase III, assume an alpha helical structure, with a core of five alpha helices, and an additional small helix. They are essential for the formation of the polymerase clamp loader.


Pssm-ID: 430418 [Multi-domain]  Cd Length: 112  Bit Score: 87.69  E-value: 1.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  209 EASTKALDGFVNvIKGTQPDMLKFSTELSKD-PLIQLGWLWHLLSDVQKLHFG----LANQAFTPSAKALCEAMSYQSAY 283
Cdd:pfam09115   2 QARKALLQALVA-LALQRGDLLSLLPLLNKDdALVRLHWLSSLLLDALKYQQGvqdqLVNQDQIALIAQLAQRLSAERLL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 515629547  284 AASNKLLTLIEQLKQHPGLNTELLIMNWLI 313
Cdd:pfam09115  81 AQLQKLLECREQLLSIPGVNRELLLTEWLL 110
PRK07471 PRK07471
DNA polymerase III subunit delta'; Validated
 68-159 2.29e-20

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236022 [Multi-domain]  Cd Length: 365  Bit Score: 90.09  E-value: 2.29e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  68 MKSGSHPDFHVIS---PEKEGK---SITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIF 141
Cdd:PRK07471  95 IAAGAHGGLLTLErswNEKGKRlrtVITVDEVRELISFFGLTAAEGGWRVVIVDTADEMNANAANALLKVLEEPPARSLF 174

                         90
                 ....*....|....*...
gi 515629547 142 ILSTRNSNRLMPTIISRC 159
Cdd:PRK07471 175 LLVSHAPARLLPTIRSRC 192
PRK06647 PRK06647
DNA polymerase III subunits gamma and tau; Validated
 16-171 1.90e-19

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235845 [Multi-domain]  Cd Length: 563  Bit Score: 88.67  E-value: 1.90e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYE-SESCGFCHSCELMKSGSHPDfhVIspEKEGKSIT-VDQV 93
Cdd:PRK06647  29 KHSIESNKIANAYIFSGPRGVGKTSSARAFARCLNCVNGPtPMPCGECSSCKSIDNDNSLD--VI--EIDGASNTsVQDV 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  94 R----------ASNRWaqessqlgglRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK06647 105 RqikeeimfppASSRY----------RVYIIDEVHMLSNSAFNALLKTIEEPPPYIVFIFATTEVHKLPATIKSRCQHFN 174


                 ....*...
gi 515629547 164 VVSPQLET 171
Cdd:PRK06647 175 FRLLSLEK 182
PRK14953 PRK14953
DNA polymerase III subunits gamma and tau; Provisional
 16-162 1.39e-18

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237867 [Multi-domain]  Cd Length: 486  Bit Score: 86.03  E-value: 1.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTN-YESESCGFCHSCELMKSGSHPDFHVISPekeGKSITVDQVR 94
Cdd:PRK14953  29 KNAVKLQRVSHAYIFAGPRGTGKTTIARILAKVLNCLNpQEGEPCGKCENCVEIDKGSFPDLIEIDA---ASNRGIDDIR 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629547  95 ASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK14953 106 ALRDAVSYTPIKGKYKVYIIDEAHMLTKEAFNALLKTLEEPPPRTIFILCTTEYDKIPPTILSRCQRF 173
dnaX_nterm TIGR02397
DNA polymerase III, subunit gamma and tau; This model represents the well-conserved first ~ ...
 48-163 7.48e-18

DNA polymerase III, subunit gamma and tau; This model represents the well-conserved first ~ 365 amino acids of the translation of the dnaX gene. The full-length product of the dnaX gene in the model bacterium E. coli is the DNA polymerase III tau subunit. A translational frameshift leads to early termination and a truncated protein subunit gamma, about 1/3 shorter than tau and present in roughly equal amounts. This frameshift mechanism is not necessarily universal for species with DNA polymerase III but appears conserved in the exterme thermophile Thermus thermophilis. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274111 [Multi-domain]  Cd Length: 355  Bit Score: 83.00  E-value: 7.48e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547   48 ALMCTNYES-ESCGFCHSCELMKSGSHPDfhVIspEKEGKSIT-VDQVRASNRWAQESSQLGGLRVILLNPAEAMNESAS 125
Cdd:TIGR02397  59 ALNCQNGPDgEPCNECESCKEINSGSSLD--VI--EIDAASNNgVDDIREILDNVKYAPSSGKYKVYIIDEVHMLSKSAF 134

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 515629547  126 NALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:TIGR02397 135 NALLKTLEEPPEHVVFILATTEPHKIPATILSRCQRFD 172
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 16-162 7.59e-18

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 84.09  E-value: 7.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYE--SESCGFCHSCELMKSGSHPDfhVIspEKEGKSIT-VDQ 92
Cdd:PRK14950  29 RNAIAEGRVAHAYLFTGPRGVGKTSTARILAKAVNCTTNDpkGRPCGTCEMCRAIAEGSAVD--VI--EMDAASHTsVDD 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  93 VRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK14950 105 AREIIERVQFRPALARYKVYIIDEVHMLSTAAFNALLKTLEEPPPHAIFILATTEVHKVPATILSRCQRF 174
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 16-179 1.00e-17

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 83.99  E-value: 1.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYE-SESCGFCHSCELMKSGSHPDFHvispEKEGKSIT-VDQV 93
Cdd:PRK08691  29 QNALDEGRLHHAYLLTGTRGVGKTTIARILAKSLNCENAQhGEPCGVCQSCTQIDAGRYVDLL----EIDAASNTgIDNI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  94 RASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF---NVVSPQLE 170
Cdd:PRK08691 105 REVLENAQYAPTAGKYKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPHKVPVTVLSRCLQFvlrNMTAQQVA 184

                        170
                 ....*....|
gi 515629547 171 TASA-WLDGE 179
Cdd:PRK08691 185 DHLAhVLDSE 194
PRK14962 PRK14962
DNA polymerase III subunits gamma and tau; Provisional
 29-162 1.93e-17

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237869 [Multi-domain]  Cd Length: 472  Bit Score: 82.51  E-value: 1.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  29 IVNAPEGLGVDALISQLTDALMCTNYES-ESCGFCHSCELMKSGSHPDFhvispekegksITVDQvrASNRWAQE----- 102
Cdd:PRK14962  40 IFAGPRGTGKTTVARILAKSLNCENRKGvEPCNECRACRSIDEGTFMDV-----------IELDA--ASNRGIDEirkir 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515629547 103 -----SSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK14962 107 davgyRPMEGKYKVYIIDEVHMLTKEAFNALLKTLEEPPSHVVFVLATTNLEKVPPTIISRCQVI 171
PRK07276 PRK07276
DNA polymerase III subunit delta'; Validated
 45-163 2.26e-17

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180916 [Multi-domain]  Cd Length: 290  Bit Score: 80.83  E-value: 2.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  45 LTDALMCTNYESE-SCGFCHSCELMKSGSHPDFHVISPEkeGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNES 123
Cdd:PRK07276  42 LAQSLFCEQKEGVlPCGHCRSCRLIEQGEFSDVTVIEPQ--GQVIKTDTIRELVKNFSQSGYEGKQQVFIIKDADKMHVN 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 515629547 124 ASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK07276 120 AANSLLKVIEEPQSEIYIFLLTNDENKVLPTIKSRTQIFH 159
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
33-168 1.30e-15

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 77.51  E-value: 1.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  33 PEGLGVDALISQLTDALMCTNY--ESESCGFCHSCELMKSGSHPDFHvispEKEGKSI-TVDQVRASNRWAQESSQLGGL 109
Cdd:PRK14971  47 PRGVGKTTCARIFAKTINCQNLtaDGEACNECESCVAFNEQRSYNIH----ELDAASNnSVDDIRNLIEQVRIPPQIGKY 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515629547 110 RVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQ--QFNVVSPQ 168
Cdd:PRK14971 123 KIYIIDEVHMLSQAAFNAFLKTLEEPPSYAIFILATTEKHKILPTILSRCQifDFNRIQVA 183
PRK14964 PRK14964
DNA polymerase III subunits gamma and tau; Provisional
 50-163 2.09e-15

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237870 [Multi-domain]  Cd Length: 491  Bit Score: 76.36  E-value: 2.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  50 MCTNYE----SESCGFCHSCELMKSGSHPDfhVIspEKEGKSIT-VDQVRA---SNRWAQESSQLgglRVILLNPAEAMN 121
Cdd:PRK14964  57 LCLNCSngptSDPCGTCHNCISIKNSNHPD--VI--EIDAASNTsVDDIKVileNSCYLPISSKF---KVYIIDEVHMLS 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 515629547 122 ESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK14964 130 NSAFNALLKTLEEPAPHVKFILATTEVKKIPVTIISRCQRFD 171
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
124-162 2.43e-14

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 73.46  E-value: 2.43e-14
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 515629547 124 ASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK14948 137 AFNALLKTLEEPPPRVVFVLATTDPQRVLPTIISRCQRF 175
PRK06645 PRK06645
DNA polymerase III subunits gamma and tau; Validated
 48-164 3.29e-14

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180643 [Multi-domain]  Cd Length: 507  Bit Score: 72.97  E-value: 3.29e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  48 ALMCTNYESESCGFCHSCELMKSGSHPDfhVISPEKEGKSiTVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNA 127
Cdd:PRK06645  71 ALITENTTIKTCEQCTNCISFNNHNHPD--IIEIDAASKT-SVDDIRRIIESAEYKPLQGKHKIFIIDEVHMLSKGAFNA 147

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 515629547 128 LLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNV 164
Cdd:PRK06645 148 LLKTLEEPPPHIIFIFATTEVQKIPATIISRCQRYDL 184
PRK14955 PRK14955
DNA polymerase III subunits gamma and tau; Provisional
 56-163 4.93e-14

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184919 [Multi-domain]  Cd Length: 397  Bit Score: 72.23  E-value: 4.93e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  56 SESCGFCHSCELMKSGSHPDfhvISPEKEGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEP 135
Cdd:PRK14955  78 TEPCGECESCRDFDAGTSLN---ISEFDAASNNSVDDIRLLRENVRYGPQKGRYRVYIIDEVHMLSIAAFNAFLKTLEEP 154

                         90       100
                 ....*....|....*....|....*...
gi 515629547 136 SSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK14955 155 PPHAIFIFATTELHKIPATIASRCQRFN 182
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
18-163 6.84e-14

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 72.22  E-value: 6.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  18 SLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYE------SESCGFCHSCELMKSGSHPDFhvispekegksITVD 91
Cdd:PRK12323  31 ALEQQRLHHAYLFTGTRGVGKTTLSRILAKSLNCTGADgeggitAQPCGQCRACTEIDAGRFVDY-----------IEMD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  92 QvrASNRWAQESSQL----------GGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQ 161
Cdd:PRK12323 100 A--ASNRGVDEMAQLldkavyaptaGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQ 177


                 ..
gi 515629547 162 FN 163
Cdd:PRK12323 178 FN 179
PRK06305 PRK06305
DNA polymerase III subunits gamma and tau; Validated
 16-215 7.08e-14

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180523 [Multi-domain]  Cd Length: 451  Bit Score: 71.73  E-value: 7.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTN--YESESCGFCHSCELMKSGSHPDfhVIspEKEGKSIT-VDQ 92
Cdd:PRK06305  30 KNALRFNRAAHAYLFSGIRGTGKTTLARIFAKALNCQNptEDQEPCNQCASCKEISSGTSLD--VL--EIDGASHRgIED 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  93 VRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVvspqleta 172
Cdd:PRK06305 106 IRQINETVLFTPSKSRYKIYIIDEVHMLTKEAFNSLLKTLEEPPQHVKFFLATTEIHKIPGTILSRCQKMHL-------- 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 515629547 173 sawldgevgKAVPQyilalnDNAPLKAKAMFEQGGVEASTKAL 215
Cdd:PRK06305 178 ---------KRIPE------ETIIDKLALIAKQEGIETSREAL 205
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 56-163 1.03e-13

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 71.51  E-value: 1.03e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  56 SESCGFCHSCELMKSGSHPDfhvISPEKEGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEP 135
Cdd:PRK14954  78 TEPCGECESCRDFDAGTSLN---ISEFDAASNNSVDDIRQLRENVRYGPQKGRYRVYIIDEVHMLSTAAFNAFLKTLEEP 154

                         90       100
                 ....*....|....*....|....*...
gi 515629547 136 SSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK14954 155 PPHAIFIFATTELHKIPATIASRCQRFN 182
PRK14956 PRK14956
DNA polymerase III subunits gamma and tau; Provisional
 16-162 1.20e-13

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184920 [Multi-domain]  Cd Length: 484  Bit Score: 71.13  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTN-YESESCGFCHSC-ELMKSGSHPDFHVISPEKEGksitVDQV 93
Cdd:PRK14956  31 QNALKSGKIGHAYIFFGPRGVGKTTIARILAKRLNCENpIGNEPCNECTSClEITKGISSDVLEIDAASNRG----IENI 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515629547  94 RASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK14956 107 RELRDNVKFAPMGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTEFHKIPETILSRCQDF 175
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 22-162 1.41e-13

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 71.25  E-value: 1.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  22 ERFPNSVIVNAPEGLGVDALISQLTDALMCTNYES-ESCGFCHSCELMKSGSHPDFhvispekegksITVDQvrASNRWA 100
Cdd:PRK14959  35 NRVAPAYLFSGTRGVGKTTIARIFAKALNCETAPTgEPCNTCEQCRKVTQGMHVDV-----------VEIDG--ASNRGI 101

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515629547 101 QESSQL----------GGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK14959 102 DDAKRLkeaigyapmeGRYKVFIIDEAHMLTREAFNALLKTLEEPPARVTFVLATTEPHKFPVTIVSRCQHF 173
PRK07132 PRK07132
DNA polymerase III subunit delta'; Validated
 109-167 2.66e-13

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180855 [Multi-domain]  Cd Length: 299  Bit Score: 68.98  E-value: 2.66e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515629547 109 LRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVSP 167
Cdd:PRK07132  91 KKILIIKNIEKTSNSLLNALLKTIEEPPKDTYFLLTTKNINKVLPTIVSRCQVFNVKEP 149
PRK05896 PRK05896
DNA polymerase III subunits gamma and tau; Validated
 25-163 2.89e-13

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235638 [Multi-domain]  Cd Length: 605  Bit Score: 70.26  E-value: 2.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  25 PNSVIVNAPEGLGVDALISQLTDALMCTNYES-ESCGFCHSCELMKSGSHPDFHVI-SPEKEGksitVDQVRASNRWAQE 102
Cdd:PRK05896  38 THAYIFSGPRGIGKTSIAKIFAKAINCLNPKDgDCCNSCSVCESINTNQSVDIVELdAASNNG----VDEIRNIIDNINY 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515629547 103 SSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK05896 114 LPTTFKYKVYIIDEAHMLSTSAWNALLKTLEEPPKHVVFIFATTEFQKIPLTIISRCQRYN 174
PRK14969 PRK14969
DNA polymerase III subunits gamma and tau; Provisional
 18-163 6.85e-13

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237873 [Multi-domain]  Cd Length: 527  Bit Score: 69.01  E-value: 6.85e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  18 SLDAERFPNSVIVNAPEGLGVDALISQLTDALMC-TNYESESCGFCHSCELMKSGSHPDFhvisPEKEGKSIT-VDQVRA 95
Cdd:PRK14969  31 ALEQQRLHHAYLFTGTRGVGKTTLARILAKSLNCeTGVTATPCGVCSACLEIDSGRFVDL----IEVDAASNTqVDAMRE 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629547  96 SNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK14969 107 LLDNAQYAPTRGRFKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFN 174
PRK05818 PRK05818
DNA polymerase III subunit delta'; Validated
 49-166 1.04e-12

DNA polymerase III subunit delta'; Validated


Pssm-ID: 235618 [Multi-domain]  Cd Length: 261  Bit Score: 66.78  E-value: 1.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  49 LMCTNYESeSCGFCHSCELMKSGSHPDFHVISPEKEG--KSITVDQVRASNRWAQESSqlgGLRVILLNPAEAMNESASN 126
Cdd:PRK05818  31 IVCTKANG-FCKTCESCLKILNGKYNDFYLIFDQKNPikKEDALSIINKLNRPSVESN---GKKIYIIYGIEKLNKQSAN 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 515629547 127 ALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVS 166
Cdd:PRK05818 107 SLLKLIEEPPKNTYGIFTTRNENNILNTILSRCVQYVVLS 146
PRK05563 PRK05563
DNA polymerase III subunits gamma and tau; Validated
 123-163 4.13e-12

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235505 [Multi-domain]  Cd Length: 559  Bit Score: 66.82  E-value: 4.13e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 515629547 123 SASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK05563 134 GAFNALLKTLEEPPAHVIFILATTEPHKIPATILSRCQRFD 174
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
18-164 4.70e-12

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 66.80  E-value: 4.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  18 SLDAERFPNSVIVNAPEGLGVDALISQLTDALMC-TNYESESCGFCHSCELMKSGSHPDFhvispekegksitVDQVRAS 96
Cdd:PRK07003  31 ALDGGRLHHAYLFTGTRGVGKTTLSRIFAKALNCeTGVTSQPCGVCRACREIDEGRFVDY-------------VEMDAAS 97

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629547  97 NRWAQESSQL----------GGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNV 164
Cdd:PRK07003  98 NRGVDEMAALleravyapvdARFKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPVTVLSRCLQFNL 175
PRK14958 PRK14958
DNA polymerase III subunits gamma and tau; Provisional
 10-173 5.17e-12

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184922 [Multi-domain]  Cd Length: 509  Bit Score: 66.29  E-value: 5.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  10 PVWSEWKKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTN-YESESCGFCHSCELMKSGSHPDFHVISPEKEGKsi 88
Cdd:PRK14958  23 PVVRALSNALDQQYLHHAYLFTGTRGVGKTTISRILAKCLNCEKgVSANPCNDCENCREIDEGRFPDLFEVDAASRTK-- 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  89 tVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVS-P 167
Cdd:PRK14958 101 -VEDTRELLDNIPYAPTKGRFKVYLIDEVHMLSGHSFNALLKTLEEPPSHVKFILATTDHHKLPVTVLSRCLQFHLAQlP 179


                 ....*.
gi 515629547 168 QLETAS 173
Cdd:PRK14958 180 PLQIAA 185
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 59-163 7.76e-12

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 65.89  E-value: 7.76e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  59 CGFCHSCELMKSGSHPDFhvispekegksITVDQvrASNRWAQESSQL----------GGLRVILLNPAEAMNESASNAL 128
Cdd:PRK14951  78 CGVCQACRDIDSGRFVDY-----------TELDA--ASNRGVDEVQQLleqavykpvqGRFKVFMIDEVHMLTNTAFNAM 144

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 515629547 129 LKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK14951 145 LKTLEEPPEYLKFVLATTDPQKVPVTVLSRCLQFN 179
PRK14970 PRK14970
DNA polymerase III subunits gamma and tau; Provisional
 33-178 1.27e-11

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184934 [Multi-domain]  Cd Length: 367  Bit Score: 64.51  E-value: 1.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  33 PEGLGVDALISQLTDALMCTNYESESCGFCHSCELMKSGSHPDFHVISPekegksiTVDQVRASnrwaqesSQLGGLRVI 112
Cdd:PRK14970  47 PRGVGKTTCARILARKINQPGYDDPNEDFSFNIFELDAASNNSVDDIRN-------LIDQVRIP-------PQTGKYKIY 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515629547 113 LLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVSPQLETASAWLDG 178
Cdd:PRK14970 113 IIDEVHMLSSAAFNAFLKTLEEPPAHAIFILATTEKHKIIPTILSRCQIFDFKRITIKDIKEHLAG 178
PRK06581 PRK06581
DNA polymerase III subunit delta'; Validated
 74-173 2.40e-11

DNA polymerase III subunit delta'; Validated


Pssm-ID: 235833 [Multi-domain]  Cd Length: 263  Bit Score: 62.94  E-value: 2.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  74 PDFHVISPEKEG----KSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEE-PSSKCIFILSTRNS 148
Cdd:PRK06581  51 PDYHFIARETSAtsnaKNISIEQIRKLQDFLSKTSAISGYKVAIIYSAELMNLNAANSCLKILEDaPKNSYIFLITSRAA 130

                         90       100
                 ....*....|....*....|....*
gi 515629547 149 NrLMPTIISRCQQFNVVSPQLETAS 173
Cdd:PRK06581 131 S-IISTIRSRCFKINVRSSILHAYN 154
PRK07133 PRK07133
DNA polymerase III subunits gamma and tau; Validated
 90-163 2.69e-10

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235943 [Multi-domain]  Cd Length: 725  Bit Score: 61.37  E-value: 2.69e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515629547  90 VDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK07133 100 VDEIRELIENVKNLPTQSKYKIYIIDEVHMLSKSAFNALLKTLEEPPKHVIFILATTEVHKIPLTILSRVQRFN 173
PRK05564 PRK05564
DNA polymerase III subunit delta'; Validated
 83-160 3.58e-10

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180132 [Multi-domain]  Cd Length: 313  Bit Score: 60.05  E-value: 3.58e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629547  83 KEGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQ 160
Cdd:PRK05564  68 INKKSIGVDDIRNIIEEVNKKPYEGDKKVIIIYNSEKMTEQAQNAFLKTIEEPPKGVFIILLCENLEQILDTIKSRCQ 145
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
18-164 8.51e-10

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 59.68  E-value: 8.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  18 SLDAERFPNSVIVNAPEGLGVDALISQLTDALMC-TNYESESCGFCHSCELMKSGSHPDFHVISPEKEGKsitVDQVRAS 96
Cdd:PRK14960  30 ALERGRLHHAYLFTGTRGVGKTTIARILAKCLNCeTGVTSTPCEVCATCKAVNEGRFIDLIEIDAASRTK---VEDTREL 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629547  97 NRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNV 164
Cdd:PRK14960 107 LDNVPYAPTQGRFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQKLPITVISRCLQFTL 174
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
 18-164 2.21e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 58.17  E-value: 2.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  18 SLDAERFPNSVIVNAPEGLGVDALISQLTDALMC-TNYESESCGFCHSCELMKSGSHPDFhvisPEKEGKSIT-VDQVRA 95
Cdd:PRK14957  31 ALETQKVHHAYLFTGTRGVGKTTLGRLLAKCLNCkTGVTAEPCNKCENCVAINNNSFIDL----IEIDAASRTgVEETKE 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515629547  96 SNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNV 164
Cdd:PRK14957 107 ILDNIQYMPSQGRYKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYHKIPVTILSRCIQLHL 175
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 16-163 4.35e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 57.44  E-value: 4.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  16 KKSLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYES-ESCGFCHSCELMKSGSHPDfhVIspEKEGKSIT-VDQV 93
Cdd:PRK14965  29 QNAIDTGRVAHAFLFTGARGVGKTSTARILAKALNCEQGLTaEPCNVCPPCVEITEGRSVD--VF--EIDGASNTgVDDI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  94 R----------ASNRWaqessqlgglRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK14965 105 RelrenvkylpSRSRY----------KIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPHKVPITILSRCQRFD 174
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
 107-159 4.86e-09

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 56.54  E-value: 4.86e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 515629547 107 GGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRC 159
Cdd:PRK12402 124 ADYKTILLDNAEALREDAQQALRRIMEQYSRTCRFIIATRQPSKLIPPIRSRC 176
PRK05917 PRK05917
DNA polymerase III subunit delta'; Validated
 73-164 6.51e-09

DNA polymerase III subunit delta'; Validated


Pssm-ID: 102059 [Multi-domain]  Cd Length: 290  Bit Score: 55.96  E-value: 6.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  73 HPDFHVISPEKEGKSITVDQVRASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLM 152
Cdd:PRK05917  60 HPDIHEFSPQGKGRLHSIETPRAIKKQIWIHPYESPYKIYIIHEADRMTLDAISAFLKVLEDPPQHGVIILTSAKPQRLP 139

                         90
                 ....*....|..
gi 515629547 153 PTIISRCQQFNV 164
Cdd:PRK05917 140 PTIRSRSLSIHI 151
PRK14952 PRK14952
DNA polymerase III subunits gamma/tau;
18-168 9.25e-09

DNA polymerase III subunits gamma/tau;


Pssm-ID: 237866 [Multi-domain]  Cd Length: 584  Bit Score: 56.43  E-value: 9.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  18 SLDAERFPNSVIVNAPEGLGVDALISQLTDALMCTNYESES-CGFCHSC-ELMKSG-SHPDFHVISPEKEGKsitVDQVR 94
Cdd:PRK14952  28 ALDAGRINHAYLFSGPRGCGKTSSARILARSLNCAQGPTATpCGVCESCvALAPNGpGSIDVVELDAASHGG---VDDTR 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515629547  95 ASNRWAQESSQLGGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQ--FNVVSPQ 168
Cdd:PRK14952 105 ELRDRAFYAPAQSRYRIFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEKVLPTIRSRTHHypFRLLPPR 180
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 107-166 3.53e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 54.73  E-value: 3.53e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 107 GGLRVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFNVVS 166
Cdd:PRK14949 118 GRFKVYLIDEVHMLSRSSFNALLKTLEEPPEHVKFLLATTDPQKLPVTVLSRCLQFNLKS 177
PRK14961 PRK14961
DNA polymerase III subunits gamma and tau; Provisional
 35-162 4.05e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184925 [Multi-domain]  Cd Length: 363  Bit Score: 54.05  E-value: 4.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  35 GLGVDALISQLTDALMCTN-YESESCGFCHSCELMKSGSHPDFHVISPEKEGKsitVDQVRASNRWAQESSQLGGLRVIL 113
Cdd:PRK14961  48 GVGKTTIARLLAKSLNCQNgITSNPCRKCIICKEIEKGLCLDLIEIDAASRTK---VEEMREILDNIYYSPSKSRFKVYL 124

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 515629547 114 LNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK14961 125 IDEVHMLSRHSFNALLKTLEEPPQHIKFILATTDVEKIPKTILSRCLQF 173
PRK08451 PRK08451
DNA polymerase III subunits gamma and tau; Validated
 48-162 9.03e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236267 [Multi-domain]  Cd Length: 535  Bit Score: 53.11  E-value: 9.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  48 ALMCTNYESES-CGFCHSCELMKSGSHPDFhvispekegksITVDQvrASNRWAQESSQL----------GGLRVILLNP 116
Cdd:PRK08451  59 ALVCEQGPSSTpCDTCIQCQSALENRHIDI-----------IEMDA--ASNRGIDDIRELieqtkykpsmARFKIFIIDE 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 515629547 117 AEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK08451 126 VHMLTKEAFNALLKTLEEPPSYVKFILATTDPLKLPATILSRTQHF 171
PRK08485 PRK08485
DNA polymerase III subunit delta'; Validated
 117-163 2.35e-07

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236274 [Multi-domain]  Cd Length: 206  Bit Score: 50.42  E-value: 2.35e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 515629547 117 AEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK08485  63 APSYGIEAQNALLKILEEPPKNICFIIVAKSKNLLLPTIRSRLIIEK 109
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 126-163 4.01e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 51.40  E-value: 4.01e-07
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 515629547 126 NALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK07994 137 NALLKTLEEPPEHVKFLLATTDPQKLPVTILSRCLQFH 174
PRK04132 PRK04132
replication factor C small subunit; Provisional
 110-162 9.08e-07

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 50.22  E-value: 9.08e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 515629547 110 RVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PRK04132 632 KIIFLDEADALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQSRCAIF 684
PRK09111 PRK09111
DNA polymerase III subunits gamma and tau; Validated
 59-163 2.13e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236382 [Multi-domain]  Cd Length: 598  Bit Score: 49.13  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  59 CGFCHSCELMKSGSHPDfhVIspEKEGKSIT-VDQVRA---SNRWAqessqlgglrvillnPAEA-----------M-NE 122
Cdd:PRK09111  86 CGVGEHCQAIMEGRHVD--VL--EMDAASHTgVDDIREiieSVRYR---------------PVSArykvyiidevhMlST 146

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 515629547 123 SASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCQQFN 163
Cdd:PRK09111 147 AAFNALLKTLEEPPPHVKFIFATTEIRKVPVTVLSRCQRFD 187
rfc PRK00440
replication factor C small subunit; Reviewed
 103-231 1.05e-05

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 46.40  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547 103 SSQLGGL--RVILLNPAEAMNESASNALLKTLEEPSSKCIFILSTRNSNRLMPTIISRCqqfnvvspqletasawldgev 180
Cdd:PRK00440  95 TAPVGGApfKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFILSCNYSSKIIDPIQSRC--------------------- 153

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 515629547 181 gkAVPQYilalndnAPLKAKAMFE-------QGGVEASTKALDGFVNVikgTQPDMLK 231
Cdd:PRK00440 154 --AVFRF-------SPLKKEAVAErlryiaeNEGIEITDDALEAIYYV---SEGDMRK 199
44 PHA02544
clamp loader, small subunit; Provisional
 85-220 6.23e-05

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 44.21  E-value: 6.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629547  85 GKSITVDQVRAS-NRWAQESSQLGGLRVILLNPAEAMNESASNALLKTL-EEPSSKCIFILSTRNSNRLMPTIISRCQQF 162
Cdd:PHA02544  76 GSDCRIDFVRNRlTRFASTVSLTGGGKVIIIDEFDRLGLADAQRHLRSFmEAYSKNCSFIITANNKNGIIEPLRSRCRVI 155

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515629547 163 NVVSP----QLETASawldgevgkavpQYIlalndnapLKAKAMFEQGGVEASTKALDGFVN 220
Cdd:PHA02544 156 DFGVPtkeeQIEMMK------------QMI--------VRCKGILEAEGVEVDMKVLAALVK 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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