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Conserved domains on  [gi|515629673|ref|WP_017062273|]
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MULTISPECIES: 1-acyl-sn-glycerol-3-phosphate acyltransferase [unclassified Vibrio]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 51-249 1.80e-31

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 115.49  E-value: 1.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  51 RLIRFSFNAFCQIMKFTGAIDYRIDGAELLRNDRNCIIVANHPSLIDYVLIASQLP-QCDCLVKAAIWENPFMKRIVKAA 129
Cdd:COG0204   10 RFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPrPVRFVAKKELFKIPLLGWLLRAL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673 130 GYIPN-----QAPDDLLERCEERFSRGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQTDLRVIHITVSPTFLTKEKKW 204
Cdd:COG0204   90 GAIPVdrskrRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLP 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 515629673 205 YQVPAskpffhvavkgKIEVEPFIEGSNNLTSAARRLNHHLAQTI 249
Cdd:COG0204  170 RPGKV-----------TVRIGPPIDPSDLEGEDRRELAERLRAAI 203
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 51-249 1.80e-31

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 115.49  E-value: 1.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  51 RLIRFSFNAFCQIMKFTGAIDYRIDGAELLRNDRNCIIVANHPSLIDYVLIASQLP-QCDCLVKAAIWENPFMKRIVKAA 129
Cdd:COG0204   10 RFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPrPVRFVAKKELFKIPLLGWLLRAL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673 130 GYIPN-----QAPDDLLERCEERFSRGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQTDLRVIHITVSPTFLTKEKKW 204
Cdd:COG0204   90 GAIPVdrskrRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLP 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 515629673 205 YQVPAskpffhvavkgKIEVEPFIEGSNNLTSAARRLNHHLAQTI 249
Cdd:COG0204  170 RPGKV-----------TVRIGPPIDPSDLEGEDRRELAERLRAAI 203
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 61-246 3.61e-28

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 105.82  E-value: 3.61e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  61 CQIMKFTGAIDYRIDGAELLRNDRNCIIVANHPSLIDYVLIASQLP-QCDCLVKAAIWENPFMKRIVKAAGYIP-----N 134
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPrPIRFVAKKELFKIPFLGWLLRLLGAIPidrgnG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673 135 QAPDDLLERCEERFSRGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQTDLRVIHITVSPTFLTKEKKWyqvpaskpff 214
Cdd:cd07989   81 RSAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKL---------- 150

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 515629673 215 hvAVKGKIEV---EPF-IEGSNNLTSAARRLNHHLA 246
Cdd:cd07989  151 --PRPGRVTVrigEPIpPEGLELAEEDRKELREKVR 184
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 86-183 1.92e-16

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 73.16  E-value: 1.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673    86 CIIVANHPSLIDYVLIASQLPQCDCLVKAAIWE----NPFMKRIVKAAGYIP-----NQAPDDLLERCEERFSRGNVMLI 156
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKelfyVPLLGWLLRLLGAIFidrsnGRKARAALREAVELLKEGEWLLI 80

                           90       100
                   ....*....|....*....|....*..
gi 515629673   157 FPEGTRTTPGIEPSLQRGAAQIATRTQ 183
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAG 107
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 73-184 2.41e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 67.69  E-value: 2.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   73 RIDGAELLRNDRNCIIVANHPSLIDYVLIASQLPQCDC----LVKAAIWENPFMKRIVKAAGYIP-----NQAPDDLLER 143
Cdd:pfam01553   3 EVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKRGRplvfVAKKELFDIPLVGWLMRLLGCIFidrknRKDAAGTLEY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 515629673  144 CEERFSRGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQT 184
Cdd:pfam01553  83 LVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGV 123
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 76-184 2.97e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 53.89  E-value: 2.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   76 GAELLRNDRNCIIVANHPSLID-YVLIASQLPQCDCLVKAAIWENPFMKRIVKAAGYIP----NQAPDD-LLERCEERFS 149
Cdd:TIGR00530   8 GPENLPAKSPVLVVANHQSNLDpLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFidreNIRAIAtALKAAIEVLK 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 515629673  150 RGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQT 184
Cdd:TIGR00530  88 QGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGV 122
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
10-252 3.50e-07

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 50.73  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   10 VFATGLCFTIFGLGglVLSFLILPTIALTN-----------PNTIKRelkaqRLIRFSFNAFcqimkftgaidYR--IDG 76
Cdd:PRK06814  384 VAGTIILALLQALG--FSIPWIILFIALANlivaililrllPTNLLR-----DIFSILFRAF-----------YRveVKG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   77 AE-LLRNDRNCIIVANHPSLIDYVLIASQLPQ-----CDCLVKAAIWENPFMKrIVKAAGYIPNQ--APDDLLERCEErf 148
Cdd:PRK06814  446 LEnLQKAGKKAVIAANHVSFLDGPLLAAYLPEeptfaIDTDIAKAWWVKPFLK-LAKALPVDPTNpmATRTLIKEVQK-- 522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  149 srGNVMLIFPEGTRTTPGiepSLQR---GAAQIATRtqTDLRVIHITVSPTFLTKEKKWYQVPASKPFFHVAVK----GK 221
Cdd:PRK06814  523 --GEKLVIFPEGRITVTG---SLMKiydGPGMIADK--AGAMVVPVRIDGLQFTHFSRLKNQVRRKWFPKVTVTilppVK 595

                         250       260       270
                  ....*....|....*....|....*....|.
gi 515629673  222 IEVEPFIEGSNNLTSAARRLNHHLAQTIFPS 252
Cdd:PRK06814  596 LAVDPELKGRERRSAAGAALYDIMSDMMFET 626
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 51-249 1.80e-31

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 115.49  E-value: 1.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  51 RLIRFSFNAFCQIMKFTGAIDYRIDGAELLRNDRNCIIVANHPSLIDYVLIASQLP-QCDCLVKAAIWENPFMKRIVKAA 129
Cdd:COG0204   10 RFRYRLVRLWARLLLRLLGVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPrPVRFVAKKELFKIPLLGWLLRAL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673 130 GYIPN-----QAPDDLLERCEERFSRGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQTDLRVIHITVSPTFLTKEKKW 204
Cdd:COG0204   90 GAIPVdrskrRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTERALPKGFLP 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 515629673 205 YQVPAskpffhvavkgKIEVEPFIEGSNNLTSAARRLNHHLAQTI 249
Cdd:COG0204  170 RPGKV-----------TVRIGPPIDPSDLEGEDRRELAERLRAAI 203
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 61-246 3.61e-28

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 105.82  E-value: 3.61e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  61 CQIMKFTGAIDYRIDGAELLRNDRNCIIVANHPSLIDYVLIASQLP-QCDCLVKAAIWENPFMKRIVKAAGYIP-----N 134
Cdd:cd07989    1 LRLLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPrPIRFVAKKELFKIPFLGWLLRLLGAIPidrgnG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673 135 QAPDDLLERCEERFSRGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQTDLRVIHITVSPTFLTKEKKWyqvpaskpff 214
Cdd:cd07989   81 RSAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKL---------- 150

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 515629673 215 hvAVKGKIEV---EPF-IEGSNNLTSAARRLNHHLA 246
Cdd:cd07989  151 --PRPGRVTVrigEPIpPEGLELAEEDRKELREKVR 184
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 86-183 1.92e-16

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 73.16  E-value: 1.92e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673    86 CIIVANHPSLIDYVLIASQLPQCDCLVKAAIWE----NPFMKRIVKAAGYIP-----NQAPDDLLERCEERFSRGNVMLI 156
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKelfyVPLLGWLLRLLGAIFidrsnGRKARAALREAVELLKEGEWLLI 80

                           90       100
                   ....*....|....*....|....*..
gi 515629673   157 FPEGTRTTPGIEPSLQRGAAQIATRTQ 183
Cdd:smart00563  81 FPEGTRSRPGKLLPFKKGAARLALEAG 107
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 73-184 2.41e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 67.69  E-value: 2.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   73 RIDGAELLRNDRNCIIVANHPSLIDYVLIASQLPQCDC----LVKAAIWENPFMKRIVKAAGYIP-----NQAPDDLLER 143
Cdd:pfam01553   3 EVHGLENLPRGGPAIVVANHQSYLDVLLLSLALYKRGRplvfVAKKELFDIPLVGWLMRLLGCIFidrknRKDAAGTLEY 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 515629673  144 CEERFSRGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQT 184
Cdd:pfam01553  83 LVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGV 123
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 76-242 2.18e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 61.51  E-value: 2.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  76 GAELLRNDRNCIIVANHP-SLIDYVLIASQLP-QCDCLVKAAIWENPFMKRIVKAAGYIP-----NQAP--------DDL 140
Cdd:cd07992   20 GRENVPKDGPVIFLGNHPnALIDPLLLAATLRrPVRFLAKADLFKNPLIGWLLESFGAIPvyrpkDLARggigkisnAAV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673 141 LERCEERFSRGNVMLIFPEGT-RTTPGIEPsLQRGAAQIA----TRTQTDLRVIhitvsPTFLTKEKKwyQVPASKpfFH 215
Cdd:cd07992  100 FDAVGEALKAGGAIGIFPEGGsHDRPRLLP-LKAGAARMAlealEAGQKDVKIV-----PVGLNYEDK--SRFRSR--VL 169

                        170       180
                 ....*....|....*....|....*..
gi 515629673 216 VAVKGKIEVEPFIEGSNNLTSAARRLN 242
Cdd:cd07992  170 VEFGKPISVSAFEEAEASRDVEKKLIN 196
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 76-184 2.97e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 53.89  E-value: 2.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   76 GAELLRNDRNCIIVANHPSLID-YVLIASQLPQCDCLVKAAIWENPFMKRIVKAAGYIP----NQAPDD-LLERCEERFS 149
Cdd:TIGR00530   8 GPENLPAKSPVLVVANHQSNLDpLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFidreNIRAIAtALKAAIEVLK 87

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 515629673  150 RGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQT 184
Cdd:TIGR00530  88 QGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGV 122
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 66-195 1.30e-07

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 50.49  E-value: 1.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  66 FTGAIDYRIDGAELLRNDRNCIIVANHPSLID-----YVLIASQLPQCDCLVKAAIWEN-PFMKRIvkaaGYIPNQAPDD 139
Cdd:cd06551    8 FFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDglilfLLLERGLRRDVYGLMDEELLERyPFFTRL----GAFSVDRDSP 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515629673 140 L-----LERCEERFSR-GNVMLIFPEGTRTTPGIEP-SLQRGAAQIATRTQTDLRVIHITVSP 195
Cdd:cd06551   84 RsaaksLKYVARLLSKpGSVVWIFPEGTRTRRDKRPlQFKPGVAHLAEKAGVPIVPVALRYTF 146
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
10-252 3.50e-07

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 50.73  E-value: 3.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   10 VFATGLCFTIFGLGglVLSFLILPTIALTN-----------PNTIKRelkaqRLIRFSFNAFcqimkftgaidYR--IDG 76
Cdd:PRK06814  384 VAGTIILALLQALG--FSIPWIILFIALANlivaililrllPTNLLR-----DIFSILFRAF-----------YRveVKG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   77 AE-LLRNDRNCIIVANHPSLIDYVLIASQLPQ-----CDCLVKAAIWENPFMKrIVKAAGYIPNQ--APDDLLERCEErf 148
Cdd:PRK06814  446 LEnLQKAGKKAVIAANHVSFLDGPLLAAYLPEeptfaIDTDIAKAWWVKPFLK-LAKALPVDPTNpmATRTLIKEVQK-- 522

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  149 srGNVMLIFPEGTRTTPGiepSLQR---GAAQIATRtqTDLRVIHITVSPTFLTKEKKWYQVPASKPFFHVAVK----GK 221
Cdd:PRK06814  523 --GEKLVIFPEGRITVTG---SLMKiydGPGMIADK--AGAMVVPVRIDGLQFTHFSRLKNQVRRKWFPKVTVTilppVK 595

                         250       260       270
                  ....*....|....*....|....*....|.
gi 515629673  222 IEVEPFIEGSNNLTSAARRLNHHLAQTIFPS 252
Cdd:PRK06814  596 LAVDPELKGRERRSAAGAALYDIMSDMMFET 626
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 73-177 1.46e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 47.23  E-value: 1.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  73 RIDGAELLRNDRNCIIVANHPSLIDYVLI------ASQLPQCDCLVKAAI-------W-----ENPFMKR-IVKAAGYIP 133
Cdd:cd07990   13 VVYGDEPKLPKERALIISNHRSEVDWLVLwmladrFGRLGRLKIVLKDSLkypplggWgwqlgEFIFLKRkWEKDEKTIK 92

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 515629673 134 NQApDDLLERcEERFSrgnvMLIFPEGTRTTPGIEPSLQRGAAQ 177
Cdd:cd07990   93 RQL-KRLKDS-PEPFW----LLIFPEGTRFTEEKKERSQEFAEK 130
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 73-193 2.17e-06

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 47.03  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  73 RIDGAE-LLRNDRNCIIVANHPSLID-YVLIasQLPQC-DCLVKAAIWENPFMKRIVKAAGYIPNQAPD-----DLLERC 144
Cdd:PLN02901  38 EVEGLEnLPSPDEPAVYVSNHQSFLDiYTLF--HLGRPfKFISKTSIFLIPIIGWAMYMTGHIPLKRMDrrsqlECLKRC 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 515629673 145 EERFSRGNVMLIFPEGTRTTPGIEPSLQRGAAQIATRTQTDlrVIHITV 193
Cdd:PLN02901 116 MELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVP--VVPITL 162
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 87-163 2.39e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 44.13  E-value: 2.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  87 IIVANHPSLIDYVLIASQLPqCDCLVKAAIWENPFMKRIVKAAG--YIPNQAPDD---LLERCEERFSRGNV--MLIFPE 159
Cdd:cd07991   27 IIVANHTSFIDPLILFSDLF-PSIVAKKELGKLPFIGTILRALGciFVDRSEPKDrkkVVEEIKERATDPNWppILIFPE 105


                 ....
gi 515629673 160 GTRT 163
Cdd:cd07991  106 GTTT 109
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 16-179 2.48e-05

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 45.30  E-value: 2.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   16 CFTIFGLGGLVLSFLI---LPtialtnpntikrelkaQRLIRFsfnafcqIMKFTGAIDYR--IDGAELLRNDRNCIIVA 90
Cdd:PRK08633  391 LFYLIALVTLIGTLYTlllLP----------------DSLLRF-------LLLLLMHTRYRlrVEGRENIPAKGGALLLG 447

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673   91 NHPSLIDY-VLIASQLPQCDCLVKAAIWENPFMKRIVKAAGYIP--NQAPDDLLERCEERFSRGNVMLIFPEGTRTTPGI 167
Cdd:PRK08633  448 NHVSWIDWaLLQAASPRPIRFVMERSIYEKWYLKWFFKLFGVIPisSGGSKESLEFIRKALDDGEVVCIFPEGAITRNGQ 527

                         170
                  ....*....|..
gi 515629673  168 EPSLQRGAAQIA 179
Cdd:PRK08633  528 LNEFKRGFELIV 539
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 70-197 1.07e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 39.15  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629673  70 IDYRIDGAELLRNDRNCIIVANHP----------SLI-----DY-VLIASQLPQCDCLVKAAIWENPFMKRivkaAGYIP 133
Cdd:cd07986    8 LEVDVSGLENIPKDGPVVIVANHPfgildglilaDLLgsvrpDVrILANQLLSKIPELRDLFIPVDPLEGR----AALAK 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515629673 134 NQAPddlLERCEERFSRGNVMLIFPEGT--RTTPG----IEPSLQRGAAQIATRTQTDLRVIHITV--SPTF 197
Cdd:cd07986   84 NRES---LREALRHLKNGGALIIFPAGRvsTASPPfgrvSDRPWNPFVARLARKAKAPVVPVYFSGrnSRLF 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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