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Conserved domains on  [gi|515629714|ref|WP_017062314|]
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MULTISPECIES: peptide chain release factor N(5)-glutamine methyltransferase [Vibrio]

Protein Classification

HemK/PrmC family methyltransferase( domain architecture ID 11483836)

HemK/PrmC family methyltransferase is a class I SAM-dependent methyltransferase that catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; such as peptide chain release factor N(5)-glutamine methyltransferase that methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:0003676|GO:0032259|GO:1904047
PubMed:  12741815|12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 6-284 2.09e-133

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


:

Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 378.74  E-value: 2.09e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   6 TVESALKAAIVKLQEgdntsPSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGEREFWS 85
Cdd:PRK09328   3 TIAEALREATARLAS-----PRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  86 LPLKVSPSTLIPRPDTERLVEVALDKTFGKQGA-ILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNI 164
Cdd:PRK09328  78 LDFKVSPGVLIPRPETEELVEWALEALLLKEPLrVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 165 TNATFLHGSWFEPLSSEgvvKFSLIVSNPPYIEKNDPHLSQGDVR-FEPITALVAEEKGLADIRYISENARGFLENEGWL 243
Cdd:PRK09328 158 ARVEFLQGDWFEPLPGG---RFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 515629714 244 AFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGRY 284
Cdd:PRK09328 235 LLEIGYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 6-284 2.09e-133

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 378.74  E-value: 2.09e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   6 TVESALKAAIVKLQEgdntsPSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGEREFWS 85
Cdd:PRK09328   3 TIAEALREATARLAS-----PRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  86 LPLKVSPSTLIPRPDTERLVEVALDKTFGKQGA-ILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNI 164
Cdd:PRK09328  78 LDFKVSPGVLIPRPETEELVEWALEALLLKEPLrVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 165 TNATFLHGSWFEPLSSEgvvKFSLIVSNPPYIEKNDPHLSQGDVR-FEPITALVAEEKGLADIRYISENARGFLENEGWL 243
Cdd:PRK09328 158 ARVEFLQGDWFEPLPGG---RFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 515629714 244 AFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGRY 284
Cdd:PRK09328 235 LLEIGYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 29-281 1.86e-129

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 367.56  E-value: 1.86e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   29 DAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGEREFWSLPLKVSPSTLIPRPDTERLVEVA 108
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  109 LDKtFGKQGAILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLSSEgvvKFSL 188
Cdd:TIGR03534  81 LER-LKKGPRVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSG---KFDL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  189 IVSNPPYIEKNDPHLSQGDVR-FEPITALVAEEKGLADIRYISENARGFLENEGWLAFEHGYDQGLAVREIMQALGYLDV 267
Cdd:TIGR03534 157 IVSNPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADV 236

                         250
                  ....*....|....
gi 515629714  268 VTEKDYGGNDRVTL 281
Cdd:TIGR03534 237 ETRKDLAGKDRVVL 250
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 6-283 7.20e-128

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 364.86  E-value: 7.20e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   6 TVESALKAAIVKLQEGDNTSPSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGEREFWS 85
Cdd:COG2890    2 TIRELLRWAAARLAAAGVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFYG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  86 LPLKVSPSTLIPRPDTERLVEVALDKTFGKQGA-ILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNI 164
Cdd:COG2890   82 LEFKVDPGVLIPRPETEELVELALALLPAGAPPrVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 165 TN-ATFLHGSWFEPLSSEGvvKFSLIVSNPPYIEKNDPHLSQGDVR-FEPITALVAEEKGLADIRYISENARGFLENEGW 242
Cdd:COG2890  162 EDrVRFLQGDLFEPLPGDG--RFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGW 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 515629714 243 LAFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGR 283
Cdd:COG2890  240 LLLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVAR 280
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 10-79 2.49e-22

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 87.92  E-value: 2.49e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   10 ALKAAIVKLQEGDNTSPSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIG 79
Cdd:pfam17827   2 ALRWASSRLKEAGIESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 119-195 5.56e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 66.68  E-value: 5.56e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515629714 119 ILDLGTGTGAIALALASEmPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLSSEGvVKFSLIVSNPPY 195
Cdd:cd02440    2 VLDLGCGTGALALALASG-PGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEAD-ESFDVIISDPPL 76
 
Name Accession Description Interval E-value
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 6-284 2.09e-133

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 378.74  E-value: 2.09e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   6 TVESALKAAIVKLQEgdntsPSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGEREFWS 85
Cdd:PRK09328   3 TIAEALREATARLAS-----PRLDAELLLAHVLGLSRTDLLLNPEEELTPEELERFRALVARRAAGEPLQYILGEAEFWG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  86 LPLKVSPSTLIPRPDTERLVEVALDKTFGKQGA-ILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNI 164
Cdd:PRK09328  78 LDFKVSPGVLIPRPETEELVEWALEALLLKEPLrVLDLGTGSGAIALALAKERPDAEVTAVDISPEALAVARRNAKHGLG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 165 TNATFLHGSWFEPLSSEgvvKFSLIVSNPPYIEKNDPHLSQGDVR-FEPITALVAEEKGLADIRYISENARGFLENEGWL 243
Cdd:PRK09328 158 ARVEFLQGDWFEPLPGG---RFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYRRIIEQAPRYLKPGGWL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 515629714 244 AFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGRY 284
Cdd:PRK09328 235 LLEIGYDQGEAVRALLAAAGFADVETRKDLAGRDRVVLGRR 275
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 29-281 1.86e-129

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 367.56  E-value: 1.86e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   29 DAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGEREFWSLPLKVSPSTLIPRPDTERLVEVA 108
Cdd:TIGR03534   1 DAELLLAHVLGKDRAQLLLHPEDELTPEELAAFDALLARRAAGEPVAYILGEREFYGLDFKVSPGVLIPRPETEELVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  109 LDKtFGKQGAILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLSSEgvvKFSL 188
Cdd:TIGR03534  81 LER-LKKGPRVLDLGTGSGAIALALAKERPDARVTAVDISPEALAVARKNARRLGLENVEFLQGDWFEPLPSG---KFDL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  189 IVSNPPYIEKNDPHLSQGDVR-FEPITALVAEEKGLADIRYISENARGFLENEGWLAFEHGYDQGLAVREIMQALGYLDV 267
Cdd:TIGR03534 157 IVSNPPYIPEADIHLLDPEVRdFEPRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGYDQGEAVRALFEAAGFADV 236

                         250
                  ....*....|....
gi 515629714  268 VTEKDYGGNDRVTL 281
Cdd:TIGR03534 237 ETRKDLAGKDRVVL 250
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 6-283 7.20e-128

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 364.86  E-value: 7.20e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   6 TVESALKAAIVKLQEGDNTSPSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGEREFWS 85
Cdd:COG2890    2 TIRELLRWAAARLAAAGVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRAAGEPLAYILGEAEFYG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  86 LPLKVSPSTLIPRPDTERLVEVALDKTFGKQGA-ILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNI 164
Cdd:COG2890   82 LEFKVDPGVLIPRPETEELVELALALLPAGAPPrVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARRNAERLGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 165 TN-ATFLHGSWFEPLSSEGvvKFSLIVSNPPYIEKNDPHLSQGDVR-FEPITALVAEEKGLADIRYISENARGFLENEGW 242
Cdd:COG2890  162 EDrVRFLQGDLFEPLPGDG--RFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLLKPGGW 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 515629714 243 LAFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTLGR 283
Cdd:COG2890  240 LLLEIGEDQGEAVRALLEAAGFADVETHKDLAGRDRVVVAR 280
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 6-284 2.95e-88

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 264.22  E-value: 2.95e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714    6 TVESALKAAIVKLQE-GDNTSPSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGEREFW 84
Cdd:TIGR00536   2 TIQEFLRWASSALSRaIARENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKGVPVAYLLGSKEFY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   85 SLPLKVSPSTLIPRPDTERLVEVALDKTFGKQGA--ILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRL 162
Cdd:TIGR00536  82 GLEFFVNEHVLIPRPETEELVEKALASLISQPPIlhILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVAEENAEKN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  163 NITNAT-FLHGSWFEPLSSegvVKFSLIVSNPPYIEKNDPHLSQGDVRFEPITALVAEEKGLADIRYISENARGFLENEG 241
Cdd:TIGR00536 162 QLEHRVeFIQSNLFEPLAG---QKIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYLKPNG 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 515629714  242 WLAFEHGYDQ-GLAVREIMQALGYLDVVTEKDYGGNDRVTLGRY 284
Cdd:TIGR00536 239 FLVCEIGNWQqKSLKELLRIKFTWYDVENGRDLNGKERVVLGFY 282
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 26-284 1.69e-62

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 203.00  E-value: 1.69e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  26 PSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGEREFWSLPLKVSPSTLIPRPDTERLV 105
Cdd:PRK14966 163 PKNEARMLLQYASEYTRVQLLTRGGEEMPDEVRQRADRLAQRRLNGEPVAYILGVREFYGRRFAVNPNVLIPRPETEHLV 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 106 EVALDKtFGKQGAILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNiTNATFLHGSWFEP-LSSEGvv 184
Cdd:PRK14966 243 EAVLAR-LPENGRVWDLGTGSGAVAVTVALERPDAFVRASDISPPALETARKNAADLG-ARVEFAHGSWFDTdMPSEG-- 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 185 KFSLIVSNPPYIEKNDPHLSQGDVRFEPITALVAEEKGLADIRYISENARGFLENEGWLAFEHGYDQGLAVREIMQALGY 264
Cdd:PRK14966 319 KWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDGLSCIRTLAQGAPDRLAEGGFLLLEHGFDQGAAVRGVLAENGF 398

                        250       260
                 ....*....|....*....|
gi 515629714 265 LDVVTEKDYGGNDRVTLGRY 284
Cdd:PRK14966 399 SGVETLPDLAGLDRVTLGKY 418
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 1-281 5.98e-58

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 193.16  E-value: 5.98e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   1 MQsaYTVESALKAAIVKLQEGDNTSPSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIGE 80
Cdd:PRK01544   1 MQ--YSIKQILSDATDKLNKIGISSPQLEARILLQHVINKPIEYLLINLDEQLNEAEIEAFEKLLERRLKHEPIAYITGV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  81 REFWSLPLKVSPSTLIPRPDTERLVEVALDKTFGKQGA-------------------------ILDLGTGTGAIALALAS 135
Cdd:PRK01544  79 KEFYSREFIVNKHVLIPRSDTEVLVDVVFQCHSRESGNpekkqlnpcfrgndissncndkflnILELGTGSGCIAISLLC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 136 EMPNRQVTGIDLRPEAQQLATENAQRLNITN-ATFLHGSWFEPLSSEgvvKFSLIVSNPPYIEKND-PHLSQGDVRFEPI 213
Cdd:PRK01544 159 ELPNANVIATDISLDAIEVAKSNAIKYEVTDrIQIIHSNWFENIEKQ---KFDFIVSNPPYISHSEkSEMAIETINYEPS 235

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629714 214 TALVAEEKGLADIRYISENARGFLENEGWLAFEHGYDQGLAVREIMQALGYLDVVTEKDYGGNDRVTL 281
Cdd:PRK01544 236 IALFAEEDGLQAYFIIAENAKQFLKPNGKIILEIGFKQEEAVTQIFLDHGYNIESVYKDLQGHSRVIL 303
PrmC_N pfam17827
PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the ...
 10-79 2.49e-22

PrmC N-terminal domain; This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors.


Pssm-ID: 436073 [Multi-domain]  Cd Length: 71  Bit Score: 87.92  E-value: 2.49e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   10 ALKAAIVKLQEGDNTSPSIDAAVLLCHALDKPRSYLLTWPEKHLTSEQESEFNALLKRRLTGEPVAYIIG 79
Cdd:pfam17827   2 ALRWASSRLKEAGIESPRLDAELLLAHVLGLDRTDLLLHPEEELSEEELERFEELLERRAAGEPLQYILG 71
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 115-263 8.46e-22

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 91.36  E-value: 8.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 115 KQGAILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNITN-ATFLHGSWFEPLSSEGVVKFSLIVSNP 193
Cdd:COG4123   37 KGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDrITVIHGDLKEFAAELPPGSFDLVVSNP 116

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 194 PYIEKNDPHLSQGDVRFepiTALVAEEKGLADIRyisENARGFLENEGWLAFEHGYDQGLAVREIMQALG 263
Cdd:COG4123  117 PYFKAGSGRKSPDEARA---IARHEDALTLEDLI---RAAARLLKPGGRFALIHPAERLAEILAALRKYG 180
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 117-195 2.59e-17

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 77.92  E-value: 2.59e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515629714 117 GAILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLSSEgvvKFSLIVSNPPY 195
Cdd:COG2813   51 GRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGLENVEVLWSDGLSGVPDG---SFDLILSNPPF 126
PRK14968 PRK14968
putative methyltransferase; Provisional
 90-196 1.14e-14

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 70.70  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  90 VSPSTLIPRPDTERLVEVALDKtfgKQGAILDLGTGTGAIALALASEmpNRQVTGIDLRPEAQQLATENAQRLNITNAT- 168
Cdd:PRK14968   1 LNDEVYEPAEDSFLLAENAVDK---KGDRVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRNNGv 75

                         90       100
                 ....*....|....*....|....*....
gi 515629714 169 -FLHGSWFEPLSSEgvvKFSLIVSNPPYI 196
Cdd:PRK14968  76 eVIRSDLFEPFRGD---KFDVILFNPPYL 101
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 119-192 2.40e-14

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 68.98  E-value: 2.40e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515629714  119 ILDLGTGTGAIALALASEM-PNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLSSEGVVKFSLIVSN 192
Cdd:pfam13847   7 VLDLGCGTGHLSFELAEELgPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEDDKFDVVISN 81
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 101-194 5.50e-14

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 71.36  E-value: 5.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 101 TERLVEVALDKtFGKQGA--ILDLGTGTGAIALALASemPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPL 178
Cdd:COG2265  218 AEALYAAALEW-LDLTGGerVLDLYCGVGTFALPLAR--RAKKVIGVEIVPEAVEDARENARLNGLKNVEFVAGDLEEVL 294

                         90
                 ....*....|....*..
gi 515629714 179 SSEGVV-KFSLIVSNPP 194
Cdd:COG2265  295 PELLWGgRPDVVVLDPP 311
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 119-195 5.56e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 66.68  E-value: 5.56e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515629714 119 ILDLGTGTGAIALALASEmPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLSSEGvVKFSLIVSNPPY 195
Cdd:cd02440    2 VLDLGCGTGALALALASG-PGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEAD-ESFDVIISDPPL 76
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 101-194 8.01e-14

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 68.00  E-value: 8.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  101 TERLVEvALDKTFGkqGAILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLSS 180
Cdd:pfam05175  20 SRLLLE-HLPKDLS--GKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGLENGEVVASDVYSGVED 96

                          90
                  ....*....|....
gi 515629714  181 EgvvKFSLIVSNPP 194
Cdd:pfam05175  97 G---KFDLIISNPP 107
PRK14967 PRK14967
putative methyltransferase; Provisional
 97-196 4.77e-13

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 67.00  E-value: 4.77e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  97 PRPDTERLVEVALDKTFGKQGAILDLGTGTGAIALAlASEMPNRQVTGIDLRPEAQQLATENAqRLNITNATFLHGSWFE 176
Cdd:PRK14967  18 PQEDTQLLADALAAEGLGPGRRVLDLCTGSGALAVA-AAAAGAGSVTAVDISRRAVRSARLNA-LLAGVDVDVRRGDWAR 95

                         90       100
                 ....*....|....*....|
gi 515629714 177 PLSSEgvvKFSLIVSNPPYI 196
Cdd:PRK14967  96 AVEFR---PFDVVVSNPPYV 112
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 98-192 2.55e-12

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 64.55  E-value: 2.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  98 RPDTERLVEVALDKTFGKQGAILDLGTGTGAIALALAsEMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSW--F 175
Cdd:COG0500    9 ELLPGLAALLALLERLPKGGRVLDLGCGTGRNLLALA-ARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLaeL 87

                         90
                 ....*....|....*..
gi 515629714 176 EPLSSEgvvKFSLIVSN 192
Cdd:COG0500   88 DPLPAE---SFDLVVAF 101
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 119-192 3.73e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 58.34  E-value: 3.73e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515629714  119 ILDLGTGTGAIALALAsEMPNRQVTGIDLRPEAQQLATENAQRLNItNATFLHGSWFE-PLSSEgvvKFSLIVSN 192
Cdd:pfam13649   1 VLDLGCGTGRLTLALA-RRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDlPFPDG---SFDLVVSS 70
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 104-208 4.86e-11

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 60.25  E-value: 4.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  104 LVEVALDKTFGKQgaILDLGTGTGAIALALASEmpNRQVTGIDLRPEAQQLATENAqRLNITNATFLHGSWFEPLSSegv 183
Cdd:TIGR00537  10 LLEANLRELKPDD--VLEIGAGTGLVAIRLKGK--GKCILTTDINPFAVKELRENA-KLNNVGLDVVMTDLFKGVRG--- 81

                          90       100
                  ....*....|....*....|....*
gi 515629714  184 vKFSLIVSNPPYIEKNDpHLSQGDV 208
Cdd:TIGR00537  82 -KFDVILFNPPYLPLED-DLRRGDW 104
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 102-192 4.58e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 56.18  E-value: 4.58e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 102 ERLVEVaLDKTFGKQGAILDLGTGTGAIALALASEmpNRQVTGIDLRPEAQQLATENAQRLNItnaTFLHGSWFE-PLSS 180
Cdd:COG2227   12 RRLAAL-LARLLPAGGRVLDVGCGTGRLALALARR--GADVTGVDISPEALEIARERAAELNV---DFVQGDLEDlPLED 85

                         90
                 ....*....|..
gi 515629714 181 EgvvKFSLIVSN 192
Cdd:COG2227   86 G---SFDLVICS 94
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
117-192 8.17e-10

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 54.83  E-value: 8.17e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515629714 117 GAILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLnitnaTFLHGSwFEPLSSEGvvKFSLIVSN 192
Cdd:COG4106    3 RRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLPNV-----RFVVAD-LRDLDPPE--PFDLVVSN 70
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
119-194 4.48e-09

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 54.91  E-value: 4.48e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515629714 119 ILDLGTGTG--AIALALASEmpnRQVTGIDLRPEAQQLATENAQRLNiTNATFLHGSWFEPlssEGVVKFSLIVSNPP 194
Cdd:COG2263   49 VLDLGCGTGmlAIGAALLGA---KKVVGVDIDPEALEIARENAERLG-VRVDFIRADVTRI---PLGGSVDTVVMNPP 119
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 81-191 1.05e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 53.39  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  81 REFWSLPLKVSpSTLIPRPDT------ERLVEVALDKTFGKQGA-ILDLGTGTGAIALALASEMpNRQVTGIDLRPEAQQ 153
Cdd:COG2230   11 RLFLDPTMTYS-CAYFEDPDDtleeaqEAKLDLILRKLGLKPGMrVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLE 88

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 515629714 154 LATENAQRLNITN-ATFLHGSWFEpLSSEGvvKFSLIVS 191
Cdd:COG2230   89 YARERAAEAGLADrVEVRLADYRD-LPADG--QFDAIVS 124
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 119-192 7.75e-08

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 50.38  E-value: 7.75e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515629714 119 ILDLGTGTGAIALALASEmpNRQVTGIDLRPEAQQLATENAQRLNItNATFLHGSWFE-PLSSEgvvKFSLIVSN 192
Cdd:COG2226   26 VLDLGCGTGRLALALAER--GARVTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDlPFPDG---SFDLVISS 94
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 119-173 1.01e-07

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 52.48  E-value: 1.01e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 515629714 119 ILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGS 173
Cdd:COG2242  251 LWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGVPNVEVVEGE 305
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 119-206 3.09e-06

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 46.33  E-value: 3.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 119 ILDLGTGTGAIALALASEMP-NRQVTGIDLRPEAQQLATENAQRLNITN-ATFLHGSWFEPLSSEGVVKFSLIV------ 190
Cdd:COG4122   20 ILEIGTGTGYSTLWLARALPdDGRLTTIEIDPERAAIARENFARAGLADrIRLILGDALEVLPRLADGPFDLVFidadks 99

                         90
                 ....*....|....*.
gi 515629714 191 SNPPYIEKNDPHLSQG 206
Cdd:COG4122  100 NYPDYLELALPLLRPG 115
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
108-192 3.22e-06

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 47.48  E-value: 3.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 108 ALDKTFGKQGAILDLGTGTG--AIALALaseMPNRQVTGIDLRPEAQQLATENAQRLNITNA-TFLHGSWFEPLssegvv 184
Cdd:COG2264  141 ALEKLLKPGKTVLDVGCGSGilAIAAAK---LGAKRVLAVDIDPVAVEAARENAELNGVEDRiEVVLGDLLEDG------ 211


                 ....*...
gi 515629714 185 KFSLIVSN 192
Cdd:COG2264  212 PYDLVVAN 219
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 120-284 7.89e-06

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 45.46  E-value: 7.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 120 LDLGTGTGAIAL-AL---AsempnRQVTGIDLRPEAQQLATENAQRLNIT-NATFLHGSWFEPLSSEGVVKFSLIVSNPP 194
Cdd:COG0742   46 LDLFAGSGALGLeALsrgA-----ASVVFVEKDRKAAAVIRKNLEKLGLEdRARVIRGDALRFLKRLAGEPFDLVFLDPP 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 195 YiekndphlSQGDVrfEPITALVAEekgladiryisenaRGFLENEGWLAFEHGYDQGLAvreimQALGYLDVVTEKDYG 274
Cdd:COG0742  121 Y--------AKGLL--EKALELLAE--------------NGLLAPGGLIVVEHSKREELP-----ELPAGLELLKERKYG 171

                        170
                 ....*....|
gi 515629714 275 GNdRVTLGRY 284
Cdd:COG0742  172 DT-RLSFYRR 180
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
119-172 8.54e-06

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 45.38  E-value: 8.54e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 515629714 119 ILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHG 172
Cdd:PRK08287  35 LIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGCGNIDIIPG 88
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
119-192 3.07e-05

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 44.37  E-value: 3.07e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515629714 119 ILDLGTGTG--AIALALaseMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLhgswfeplsSEGVVKFSLIVSN 192
Cdd:PRK00517 123 VLDVGCGSGilAIAAAK---LGAKKVLAVDIDPQAVEAARENAELNGVELNVYL---------PQGDLKADVIVAN 186
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 120-192 5.28e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 41.20  E-value: 5.28e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515629714  120 LDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSwFEPLSSEGVVKFSLIVSN 192
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELF-QLDLGELDPGSFDVVVAS 72
arsM PRK11873
arsenite methyltransferase;
119-192 5.29e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 43.78  E-value: 5.29e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515629714 119 ILDLGTGTGAIALALASEM-PNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGSwFE--PLSSEGVvkfSLIVSN 192
Cdd:PRK11873  81 VLDLGSGGGFDCFLAARRVgPTGKVIGVDMTPEMLAKARANARKAGYTNVEFRLGE-IEalPVADNSV---DVIISN 153
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 120-192 6.65e-05

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 41.11  E-value: 6.65e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515629714  120 LDLGTGTGAIALALASemPNRQVTGIDLRPEAQQLATENAQRLNItnaTFLHGSWFE-PLSSEgvvKFSLIVSN 192
Cdd:pfam08241   1 LDVGCGTGLLTELLAR--LGARVTGVDISPEMLELAREKAPREGL---TFVVGDAEDlPFPDN---SFDLVLSS 66
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 78-192 9.26e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 43.02  E-value: 9.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714   78 IGEReFWSLPL----KVSPSTLIPRPD-----------TERLVEVALDKTFGKQGAILDLGTGTGAIALAlASEMPNRQV 142
Cdd:pfam06325 110 IGER-LTIVPSwedyPENPDALNIELDpgmafgtgthpTTKLCLEALERLVKPGESVLDVGCGSGILAIA-ALKLGAKKV 187

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 515629714  143 TGIDLRPEAQQLATENAQRLNITNATFLHgswfepLSSEGVV-KFSLIVSN 192
Cdd:pfam06325 188 VGVDIDPVAVRAAKENAELNGVEARLEVY------LPGDLPKeKADVVVAN 232
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 106-178 3.48e-04

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 40.39  E-value: 3.48e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515629714  106 EVALDKTFGKQG----AILDLGTGTGAIALALASEMPNRQVTGIDLrPEAQQLATENAQRLNITNATflhgsWFEPL 178
Cdd:pfam10294  33 EMKIFKELGANNlsglNVLELGSGTGLVGIAVALLLPGASVTITDL-EEALELLKKNIELNALSSKV-----VVKVL 103
rumB PRK03522
23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
121-194 4.08e-04

23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;


Pssm-ID: 235128 [Multi-domain]  Cd Length: 315  Bit Score: 41.39  E-value: 4.08e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515629714 121 DLGTGTGAIALALASemPNRQVTGIDLRPEAQQLATENAQRLNITNATF--LHGSWFePLSSEGVVKfsLIVSNPP 194
Cdd:PRK03522 179 DLFCGVGGFGLHCAT--PGMQLTGIEISAEAIACAKQSAAELGLTNVQFqaLDSTQF-ATAQGEVPD--LVLVNPP 249
PRK06202 PRK06202
hypothetical protein; Provisional
 119-192 6.83e-04

hypothetical protein; Provisional


Pssm-ID: 180466 [Multi-domain]  Cd Length: 232  Bit Score: 39.98  E-value: 6.83e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515629714 119 ILDLGTGTGAIALALASeMPNRQ-----VTGIDLRPEAQQLATENAQRLNITNATFLHGSwfepLSSEGvVKFSLIVSN 192
Cdd:PRK06202  64 LLDIGCGGGDLAIDLAR-WARRDglrleVTAIDPDPRAVAFARANPRRPGVTFRQAVSDE----LVAEG-ERFDVVTSN 136
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
102-263 1.35e-03

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 38.83  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 102 ERLVEVALDKTFGKQGA-ILDLGTGTGAIALALAsEMPNRqVTGIDLRPEAQQLATENAQRLNITNATFLHgswFEPLSS 180
Cdd:COG4976   32 ALLAEELLARLPPGPFGrVLDLGCGTGLLGEALR-PRGYR-LTGVDLSEEMLAKAREKGVYDRLLVADLAD---LAEPDG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 181 egvvKFSLIVSNppyiekndphlsqgDVrfepitaLVAeekgLADIRYISENARGFLENEGWLAF-------EHGYDQGL 253
Cdd:COG4976  107 ----RFDLIVAA--------------DV-------LTY----LGDLAAVFAGVARALKPGGLFIFsvedadgSGRYAHSL 157

                        170
                 ....*....|.
gi 515629714 254 A-VREIMQALG 263
Cdd:COG4976  158 DyVRDLLAAAG 168
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
116-195 2.34e-03

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 38.77  E-value: 2.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 116 QGAILDLGTGTGAIALALASEMPNRQVTGIDLrpeaQQLATENAQRLNITNAtfLHGSWFEP-LSSEGVVKFSLIVSNPP 194
Cdd:PRK09489 197 KGKVLDVGCGAGVLSAVLARHSPKIRLTLSDV----SAAALESSRATLAANG--LEGEVFASnVFSDIKGRFDMIISNPP 270


                 .
gi 515629714 195 Y 195
Cdd:PRK09489 271 F 271
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
108-195 3.18e-03

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 38.39  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 108 ALDKTFGKQGA-ILDLGTGTGAIALALASEMPNR-QVTGIDLRPEAQQLATENAQRLNItNATFLHGSWFEPLSSEgvvK 185
Cdd:COG0827  107 LVEKFTKKEGLrILDPAVGTGNLLTTVLNQLKKKvNAYGVEVDDLLIRLAAVLANLQGH-PVELFHQDALQPLLID---P 182

                         90
                 ....*....|
gi 515629714 186 FSLIVSNPPY 195
Cdd:COG0827  183 VDVVISDLPV 192
Rsm22 COG5459
Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal ...
 102-190 3.67e-03

Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) [Translation, ribosomal structure and biogenesis]; Ribosomal protein RSM22 (predicted mitochondrial rRNA methylase) is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 444210 [Multi-domain]  Cd Length: 306  Bit Score: 38.40  E-value: 3.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714 102 ERLVEVALDKTfgkQGAILDLGTGTGAIALALASEMPN-RQVTGIDLRPEAQQLATENAQRLNITNATFLHGSWFEPLSS 180
Cdd:COG5459   70 AELAEAGPDFA---PLTVLDVGAGPGTAAWAAADAWPSlLDATLLERSAAALALGRRLARAAANPALETAEWRLADLAAA 146

                         90
                 ....*....|
gi 515629714 181 EGVVKFSLIV 190
Cdd:COG5459  147 LPAPPADLVV 156
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 119-172 4.11e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 37.83  E-value: 4.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 515629714 119 ILDLGTGTGAIALALASEM-PNRQVTGIDLRPEAQQLATENAQRLNIT-NATFLHG 172
Cdd:COG2519   95 VLEAGTGSGALTLALARAVgPEGKVYSYERREDFAEIARKNLERFGLPdNVELKLG 150
PRK07402 PRK07402
precorrin-6Y C5,15-methyltransferase subunit CbiT;
121-173 4.67e-03

precorrin-6Y C5,15-methyltransferase subunit CbiT;


Pssm-ID: 180961  Cd Length: 196  Bit Score: 37.28  E-value: 4.67e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 515629714 121 DLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLNITNATFLHGS 173
Cdd:PRK07402  46 DIGAGTGTIPVEAGLLCPKGRVIAIERDEEVVNLIRRNCDRFGVKNVEVIEGS 98
Eco57I pfam07669
Eco57I restriction-modification methylase; homologs of the Escherichia coli Eco57I ...
 184-244 6.83e-03

Eco57I restriction-modification methylase; homologs of the Escherichia coli Eco57I restriction-modification methylase are found in several phylogenetically diverse bacteria. The structure of TaqI has been solved.


Pssm-ID: 369456 [Multi-domain]  Cd Length: 104  Bit Score: 35.35  E-value: 6.83e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  184 VKFSLIVSNPPYIEKNDphLSQGDVRFEPI------TALVAEEKGLADI---RYISENARGFLENEGWLA 244
Cdd:pfam07669   1 MKFDVIIGNPPYQESNG--GAGLGNSAAPIyqyfveLADKLEPKYLAMIipaRWIHNSGKGLKEFREKML 68
Methyltransf_32 pfam13679
Methyltransferase domain; This family appears to be a methyltransferase domain.
 104-181 7.87e-03

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 379330 [Multi-domain]  Cd Length: 138  Bit Score: 36.01  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515629714  104 LVEVALDKTFGKQGA--ILDLGTGTGAIALALASEMPNRQVTGIDLRPEAQQLATENAQRLN-ITNATFLHGSWFEPLSS 180
Cdd:pfam13679  12 FIAPLLKELLDENGPitIVDHGAGKGYLGFILYYLKYGVRVYGIDTRAELVEKANALAQKLGfNKRMSFLEGTIAGSTPV 91


                  .
gi 515629714  181 E 181
Cdd:pfam13679  92 E 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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