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Conserved domains on  [gi|515630954|ref|WP_017063554|]
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MULTISPECIES: class Ia ribonucleoside-diphosphate reductase subunit beta [Vibrio]

Protein Classification

ribonucleotide-diphosphate reductase subunit beta( domain architecture ID 10793142)

ribonucleotide-diphosphate reductase subunit beta catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides, providing the precursors necessary for DNA synthesis

CATH:  1.10.620.20
EC:  1.17.4.1
Gene Ontology:  GO:0009263|GO:0006260|GO:0046872|GO:0004748|GO:0005971
PubMed:  34461093|16756507
SCOP:  4000846

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 1-377 0e+00

ribonucleotide-diphosphate reductase subunit beta; Reviewed


:

Pssm-ID: 181647  Cd Length: 376  Bit Score: 861.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954   1 MAYSTFSQQKNDQLKEPMFLGQSVNVARYDQQKFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKY 80
Cdd:PRK09101   1 MAYTTFSQTKNDQLKEPMFFGQSVNVARYDQQKYEIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  81 QTLLDSIQGRSPNVALLPLVSLPEVETWIETWSFSETIHSRSYTHIIRNIVNDPGVVFDDIVENEEILKRAKDIAFYYDD 160
Cdd:PRK09101  81 QTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEEILKRAKDISSYYDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 161 LIKLTADYHRYGEGNHSINGEDVKISLHDLKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEA 240
Cdd:PRK09101 161 LIEMTSYYHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 241 LHLTGTQHMINLLRNGQDDFEFMQIAEECKQECFDLFKEAAEQEKEWAEYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320
Cdd:PRK09101 241 LHLTGTQHMLNLMRSGKDDPEMAEIAEECKQECYDLFVQAAEQEKEWADYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 515630954 321 GLGTAYPaATSNPIPWINAWLSSDNVQVAPQEAEISSYLVGQIDNEVKADDFEGFEL 377
Cdd:PRK09101 321 GLDLPFQ-TRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSDFEL 376
 
Name Accession Description Interval E-value
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 1-377 0e+00

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 181647  Cd Length: 376  Bit Score: 861.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954   1 MAYSTFSQQKNDQLKEPMFLGQSVNVARYDQQKFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKY 80
Cdd:PRK09101   1 MAYTTFSQTKNDQLKEPMFFGQSVNVARYDQQKYEIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  81 QTLLDSIQGRSPNVALLPLVSLPEVETWIETWSFSETIHSRSYTHIIRNIVNDPGVVFDDIVENEEILKRAKDIAFYYDD 160
Cdd:PRK09101  81 QTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEEILKRAKDISSYYDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 161 LIKLTADYHRYGEGNHSINGEDVKISLHDLKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEA 240
Cdd:PRK09101 161 LIEMTSYYHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 241 LHLTGTQHMINLLRNGQDDFEFMQIAEECKQECFDLFKEAAEQEKEWAEYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320
Cdd:PRK09101 241 LHLTGTQHMLNLMRSGKDDPEMAEIAEECKQECYDLFVQAAEQEKEWADYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 515630954 321 GLGTAYPaATSNPIPWINAWLSSDNVQVAPQEAEISSYLVGQIDNEVKADDFEGFEL 377
Cdd:PRK09101 321 GLDLPFQ-TRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSDFEL 376
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 14-370 3.29e-134

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 386.45  E-value: 3.29e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  14 LKEPMFLGQSVNVARYDQQKFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSPN 93
Cdd:COG0208    1 LDEPIINGLTTNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  94 VALLPLVSLPEVETWIETWSFSETIHSRSYTHIIRNIVNDPGVVFDDIVENEEILKRAKDIAFYYDDLikltadyhryge 173
Cdd:COG0208   81 LALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDEIFNWIEENPALQKKAEFILKYYDDL------------ 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 174 gnhsingedvkiSLHDLKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLL 253
Cdd:COG0208  149 ------------GTRETKKDLLKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINTI 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 254 RNGQDDFefmqIAEECKQECFDLFKEAAEQEKEWAEYLFKDGsMIGLNKDILCQYVEYITNIRMQAVGLGTAYPaATSNP 333
Cdd:COG0208  217 REENPEL----FTEELKEEIYELLKEAVELEKEYADDLFPDG-ILGLNAEDVKQYIRYIANKRLMNLGLEPLFE-GDVNP 290

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 515630954 334 IPWINAWLSSDNvQVAPQEAEISSYLVGQIDNEVKAD 370
Cdd:COG0208  291 FPWMSEGLDLNK-KTDFFETRVTEYQKGGVESTFDED 326
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 29-340 1.44e-81

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 251.01  E-value: 1.44e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  29 YDQQKFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSLPEVETW 108
Cdd:cd01049    3 LNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEARAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 109 IETWSFSETIHSRSYTHIIRNIVNDPGV--VFDDIVENEEILKRAKDIAFYYDDLIKLTadyhrygegnhsingedvkis 186
Cdd:cd01049   83 YGFQAFMENIHSESYSYILDTLGKDEERdeLFEAIETDPALKKKADWILRWYDNLDDNT--------------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 187 lhdlKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLLRNGQDDFEfmqiA 266
Cdd:cd01049  142 ----KESFAERLVAFAILEGIFFYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNENPELF----T 213

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515630954 267 EECKQECFDLFKEAAEQEKEWAEYLFKDGsMIGLNKDILCQYVEYITNIRMQAVGLGTAYPAATSNPIPWINAW 340
Cdd:cd01049  214 EEFKEEVYELIKEAVELEKEFARDLLPDG-ILGLNKEDMKQYIEYVANRRLENLGLEKLFNVEDKNPFDWMELI 286
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
33-333 6.97e-49

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 166.14  E-value: 6.97e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954   33 KFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSLPEVETWIETW 112
Cdd:pfam00268   8 KYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEARAFYGFQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  113 SFSETIHSRSYTHIIRNIVNDP---GVVFDDIVENEEILKRAKDIAFYYDDlikltadyhrygegnhsingedvkiSLHD 189
Cdd:pfam00268  88 AFMENIHSESYSYILDTLGKDPeeiDELFNWIETNPALQKKAEWILKWYQD-------------------------FDSD 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  190 LKKKLylcLMSVnALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLLRNGQDDFEfmqiAEEC 269
Cdd:pfam00268 143 FLERL---VAFA-ILEGIFFYSGFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKEENPELE----TKEL 214

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515630954  270 KQECFDLFKEAAEQEKEWAEYLFKDGsMIGLNKDILCQYVEYITNIRMQAVGLGTAYPaATSNP 333
Cdd:pfam00268 215 KEEVYDLIKEAVELEKEFLDDALPVG-LLGMNAEDVKQYIEYVADRRLMNLGYEKLYN-VEVNP 276
 
Name Accession Description Interval E-value
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 1-377 0e+00

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 181647  Cd Length: 376  Bit Score: 861.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954   1 MAYSTFSQQKNDQLKEPMFLGQSVNVARYDQQKFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKY 80
Cdd:PRK09101   1 MAYTTFSQTKNDQLKEPMFFGQSVNVARYDQQKYEIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  81 QTLLDSIQGRSPNVALLPLVSLPEVETWIETWSFSETIHSRSYTHIIRNIVNDPGVVFDDIVENEEILKRAKDIAFYYDD 160
Cdd:PRK09101  81 QTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEEILKRAKDISSYYDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 161 LIKLTADYHRYGEGNHSINGEDVKISLHDLKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEA 240
Cdd:PRK09101 161 LIEMTSYYHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 241 LHLTGTQHMINLLRNGQDDFEFMQIAEECKQECFDLFKEAAEQEKEWAEYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320
Cdd:PRK09101 241 LHLTGTQHMLNLMRSGKDDPEMAEIAEECKQECYDLFVQAAEQEKEWADYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 515630954 321 GLGTAYPaATSNPIPWINAWLSSDNVQVAPQEAEISSYLVGQIDNEVKADDFEGFEL 377
Cdd:PRK09101 321 GLDLPFQ-TRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSDFEL 376
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 14-370 3.29e-134

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 386.45  E-value: 3.29e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  14 LKEPMFLGQSVNVARYDQQKFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSPN 93
Cdd:COG0208    1 LDEPIINGLTTNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  94 VALLPLVSLPEVETWIETWSFSETIHSRSYTHIIRNIVNDPGVVFDDIVENEEILKRAKDIAFYYDDLikltadyhryge 173
Cdd:COG0208   81 LALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDEIFNWIEENPALQKKAEFILKYYDDL------------ 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 174 gnhsingedvkiSLHDLKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLL 253
Cdd:COG0208  149 ------------GTRETKKDLLKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINTI 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 254 RNGQDDFefmqIAEECKQECFDLFKEAAEQEKEWAEYLFKDGsMIGLNKDILCQYVEYITNIRMQAVGLGTAYPaATSNP 333
Cdd:COG0208  217 REENPEL----FTEELKEEIYELLKEAVELEKEYADDLFPDG-ILGLNAEDVKQYIRYIANKRLMNLGLEPLFE-GDVNP 290

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 515630954 334 IPWINAWLSSDNvQVAPQEAEISSYLVGQIDNEVKAD 370
Cdd:COG0208  291 FPWMSEGLDLNK-KTDFFETRVTEYQKGGVESTFDED 326
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 29-340 1.44e-81

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 251.01  E-value: 1.44e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  29 YDQQKFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSLPEVETW 108
Cdd:cd01049    3 LNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEARAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 109 IETWSFSETIHSRSYTHIIRNIVNDPGV--VFDDIVENEEILKRAKDIAFYYDDLIKLTadyhrygegnhsingedvkis 186
Cdd:cd01049   83 YGFQAFMENIHSESYSYILDTLGKDEERdeLFEAIETDPALKKKADWILRWYDNLDDNT--------------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 187 lhdlKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLLRNGQDDFEfmqiA 266
Cdd:cd01049  142 ----KESFAERLVAFAILEGIFFYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNENPELF----T 213

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515630954 267 EECKQECFDLFKEAAEQEKEWAEYLFKDGsMIGLNKDILCQYVEYITNIRMQAVGLGTAYPAATSNPIPWINAW 340
Cdd:cd01049  214 EEFKEEVYELIKEAVELEKEFARDLLPDG-ILGLNKEDMKQYIEYVANRRLENLGLEKLFNVEDKNPFDWMELI 286
nrdF PRK09614
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 17-347 1.99e-53

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 236591 [Multi-domain]  Cd Length: 324  Bit Score: 179.64  E-value: 1.99e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  17 PMFLGQSVNVARYDQQKFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSPNVAL 96
Cdd:PRK09614   2 KIIGGNTYSAINWNKIEDPWDYEAWKRLTANFWLPEEVPLSNDLKDWKKLSDEEKNLYTRVFGGLTLLDTLQNNNGMPNL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  97 LPLVSLPEVETWIETWSFSETIHSRSYTHIIRNIVNDPGV--VFDDIVENEEILKRAKDIAFYYddlikltadyhrygeg 174
Cdd:PRK09614  82 MPDITTPEEEAVLANIAFMEAVHAKSYSYIFSTLCSPEEIdeAFEWAEENPYLQKKADIIQDFY---------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 175 nhsingedvkislHDLKKKLYLCLMSVNA-LEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLL 253
Cdd:PRK09614 146 -------------EPLKKKILRKAAVASVfLEGFLFYSGFYYPLYLARQGKMTGTAQIIRLIIRDESLHGYYIGYLFQEG 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 254 RNGQDDFEfmqiAEECKQECFDLFKEAAEQEKEWAEYLFKDgsmIGLNKDILcQYVEYITNIRMQAVGLGTAYPAATSNP 333
Cdd:PRK09614 213 LEELPELE----QEELKDEIYDLLYELYENEEAYTELLYDI---VGLAEDVK-KYIRYNANKRLMNLGLEPLFPEEEEVN 284

                        330
                 ....*....|....
gi 515630954 334 IPWINAwLSSDNVQ 347
Cdd:PRK09614 285 PIWLNG-LSNNADE 297
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
33-333 6.97e-49

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 166.14  E-value: 6.97e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954   33 KFEIFEKLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSLPEVETWIETW 112
Cdd:pfam00268   8 KYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEARAFYGFQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  113 SFSETIHSRSYTHIIRNIVNDP---GVVFDDIVENEEILKRAKDIAFYYDDlikltadyhrygegnhsingedvkiSLHD 189
Cdd:pfam00268  88 AFMENIHSESYSYILDTLGKDPeeiDELFNWIETNPALQKKAEWILKWYQD-------------------------FDSD 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  190 LKKKLylcLMSVnALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLLRNGQDDFEfmqiAEEC 269
Cdd:pfam00268 143 FLERL---VAFA-ILEGIFFYSGFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKEENPELE----TKEL 214

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515630954  270 KQECFDLFKEAAEQEKEWAEYLFKDGsMIGLNKDILCQYVEYITNIRMQAVGLGTAYPaATSNP 333
Cdd:pfam00268 215 KEEVYDLIKEAVELEKEFLDDALPVG-LLGMNAEDVKQYIEYVADRRLMNLGYEKLYN-VEVNP 276
PRK07209 PRK07209
ribonucleotide-diphosphate reductase subunit beta; Validated
 49-336 2.00e-24

ribonucleotide-diphosphate reductase subunit beta; Validated


Pssm-ID: 235968  Cd Length: 369  Bit Score: 102.77  E-value: 2.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  49 WRPEEVDVSSDrI----DYNKLPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSLPEVETWIETWSFSETIHSRSYT 124
Cdd:PRK07209  71 WMPQEVNMSRD-IalwkSPNGLTEDERRIVKRNLGFFSTADSLVANNIVLAIYRHITNPECRQYLLRQAFEEAIHTHAYQ 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 125 HIIRNIVNDPGVVFDDIVENEEIlkRAKDiAFyyddLIKLTadyhrygegnHSINGEDVKISLHDLKKKL------YLCL 198
Cdd:PRK07209 150 YIVESLGLDEGEIFNMYHEVPSI--RAKD-EF----LIPFT----------RSLTDPNFKTGTPENDQKLlrnliaFYCI 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 199 MsvnalEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLLRngqddFEFMQI-AEECKQECFDLF 277
Cdd:PRK07209 213 M-----EGIFFYVGFTQILSLGRQNKMTGIAEQYQYILRDESMHLNFGIDLINQIK-----LENPHLwTAEFQAEIRELI 282

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515630954 278 KEAAEQEKEWAEYLFKDGsMIGLNKDILCQYVEYITNIRMQAVGLGTAYPaATSNPIPW 336
Cdd:PRK07209 283 KEAVELEYRYARDTMPRG-VLGLNASMFKDYLRFIANRRLQQIGLKPQYP-GTENPFPW 339
PRK13965 PRK13965
ribonucleotide-diphosphate reductase subunit beta; Provisional
 14-372 6.48e-19

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 184425 [Multi-domain]  Cd Length: 335  Bit Score: 86.75  E-value: 6.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  14 LKEPMFLGQSVNVARYDQQK-FEIFEKLIEKqlsfFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSP 92
Cdd:PRK13965  15 LSETQKPLRSINWNYLNDDKdLEVWNRVTQN----FWLPEKVPVSNDLNSWRSLGEDWQQLITRTFTGLTLLDTVQATVG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  93 NVALLPLVSLPEVETWIETWSFSETIHSRSYTHIIRNIVNDPGV--VFDDIVENEEILKRAKDIAFYYddlikltadyhr 170
Cdd:PRK13965  91 DVAQIPHSQTDHEQVIYTNFAFMVAIHARSYGTIFSTLCSSEQIeeAHEWVVSTESLQRRARVLIPYY------------ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 171 ygegnhsiNGEDvkislhDLKKKLYLCLMSvnaleAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALH--LTGTQH 248
Cdd:PRK13965 159 --------TGDD------PLKSKVAAAMMP-----GFLLYGGFYLPFYLSARGKLPNTSDIIRLILRDKVIHnyYSGYKY 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 249 MINLLRngqddfEFMQIAEECKQECFDLFKEAAEQEKEWAEYLFKDgsmIGLNKDILcQYVEYITNIRMQAVGLGTAYPA 328
Cdd:PRK13965 220 QQKVAR------LSPEKQAEMKAFVFDLLYELIDLEKAYLRELYAG---FDLAEDAI-RFSLYNAGKFLQNLGYESPFTE 289

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 515630954 329 ATSNPIPWINAWLSsdnvqvaPQEAEI--------SSYLVGQIDNEVKAD-DF 372
Cdd:PRK13965 290 EETRVSPEVFAQLS-------ARADENhdffsgngSSYVMGITEETTDDDwEF 335
nrdF2 PRK13966
ribonucleotide-diphosphate reductase subunit beta; Provisional
 30-372 1.06e-16

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140022  Cd Length: 324  Bit Score: 80.15  E-value: 1.06e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  30 DQQKFEIFEKLIEKqlsfFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSLPEVETWI 109
Cdd:PRK13966  21 DEKDAEVWDRLTGN----FWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDALTPHEEAVL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 110 ETWSFSETIHSRSYTHIIRNIVNDPGV--VFDDIVENEEILKRAKDIAFYYddlikltadyhrygegnhsiNGEDvkisl 187
Cdd:PRK13966  97 TNIAFMESVHAKSYSQIFSTLCSTAEIddAFRWSEENRNLQRKAEIVLQYY--------------------RGDE----- 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 188 hDLKKKLYLCLmsvnaLEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALH--LTGTQHMINLLRNGQDDfefmqi 265
Cdd:PRK13966 152 -PLKRKVASTL-----LESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHgyYIGYKFQRGLALVDDVT------ 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 266 AEECKQECFDLFKEAAEQEKEWAEYLFKDgsmIGLNKDILcQYVEYITNIRMQAVGLGTAYPAATSNPIPWINAWLSSDn 345
Cdd:PRK13966 220 RAELKDYTYELLFELYDNEVEYTQDLYDE---VGLTEDVK-KFLRYNANKALMNLGYEALFPRDETDVNPAILSALSPN- 294

                        330       340       350
                 ....*....|....*....|....*....|...
gi 515630954 346 vqvAPQEAEI-----SSYLVGQIDNEVKAD-DF 372
Cdd:PRK13966 295 ---ADENHDFfsgsgSSYVIGKAVVTEDDDwDF 324
PTZ00211 PTZ00211
ribonucleoside-diphosphate reductase small subunit; Provisional
 7-337 4.35e-16

ribonucleoside-diphosphate reductase small subunit; Provisional


Pssm-ID: 240315 [Multi-domain]  Cd Length: 330  Bit Score: 78.27  E-value: 4.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954   7 SQQKNDQLKEPMFlgqsvnvaRYDQQKFEIFE-------KLIEKQLSFFWRPEEVDVSSDRIDYNKLPEHEKHiFISN-L 78
Cdd:PTZ00211   3 EAMKENEEEEPLL--------KENPDRFVLFPikypdiwRMYKKAEASFWTAEEIDLGNDLKDWEKLNDGERH-FIKHvL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  79 KYQTLLDSIQGRSPNVALLPLVSLPEVETWietWSFS---ETIHSRSYTHIIRNIVNDPgvvfddiVENEEILKRAKDIa 155
Cdd:PTZ00211  74 AFFAASDGIVLENLAQRFMREVQVPEARCF---YGFQiamENIHSETYSLLIDTYITDE-------EEKDRLFHAIETI- 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 156 fyydDLIKLTADYHRYGEGNHSINGEDvkislhdlkkklylcLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIKLI 235
Cdd:PTZ00211 143 ----PAIKKKAEWAAKWINSSNSFAER---------------LVAFAAVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELI 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 236 ARDEALHLTGTQHMINLLRNgqddfefmQIAEECKQEcfdLFKEAAEQEKEW-AEYLFKDgsMIGLNKDILCQYVEYITN 314
Cdd:PTZ00211 204 SRDEGLHTDFACLLYSHLKN--------KLPRERVQE---IIKEAVEIEREFiCDALPVD--LIGMNSRLMAQYIEFVAD 270

                        330       340
                 ....*....|....*....|...
gi 515630954 315 IRMQAVGLGTAYpaATSNPIPWI 337
Cdd:PTZ00211 271 RLLVALGVPKIY--NSKNPFDWM 291
nrdF1 PRK13967
ribonucleotide-diphosphate reductase subunit beta; Provisional
 30-341 9.97e-14

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140023  Cd Length: 322  Bit Score: 71.30  E-value: 9.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  30 DQQKFEIFEKLIEKqlsfFWRPEEVDVSSDRIDYNKLPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSLPEVETWI 109
Cdd:PRK13967  19 DAKDLQVWERLTGN----FWLPEKIPLSNDLASWQTLSSTEQQTTIRVFTGLTLLDTAQATVGAVAMIDDAVTPHEEAVL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 110 ETWSFSETIHSRSYTHIIRNIVNDPGV--VFDDIVENEEILKRAKDIAFYYddlikltadyhrygegnhsiNGEDVkisl 187
Cdd:PRK13967  95 TNMAFMESVHAKSYSSIFSTLCSTKQIddAFDWSEQNPYLQRKAQIIVDYY--------------------RGDDA---- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 188 hdLKKKlylclMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHltgTQHMINLLRNGQDDFEFMQIAE 267
Cdd:PRK13967 151 --LKRK-----ASSVMLESFLFYSGFYLPMYWSSRGKLTNTADLIRLIIRDEAVH---GYYIGYKCQRGLADLTDAERAD 220

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515630954 268 ECKQECfDLFKEAAEQEKEWAEYLFKDgsmIGLNKDILcQYVEYITNIRMQAVGLGTAYPAATSNPIPWINAWL 341
Cdd:PRK13967 221 HREYTC-ELLHTLYANEIDYAHDLYDE---LGWTDDVL-PYMRYNANKALANLGYQPAFDRDTCQVNPAVRAAL 289
PRK12759 PRK12759
bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional
 49-341 9.76e-13

bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional


Pssm-ID: 139206 [Multi-domain]  Cd Length: 410  Bit Score: 68.90  E-value: 9.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  49 WRPEEVDVSSDRIDYN--KLPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSLPEVETWIETWSFSETIHSRSYthi 126
Cdd:PRK12759 120 WIEDEIDLSEDVTDWKngKITKVEKEYITNILRLFTQSDVAVGQNYYDQFIPLFKNNEIRNMLGSFAAREGIHQRAY--- 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 127 irnivndpgvvfddiveneeilkrakdiAFYYDDLIKLTADYHRYGEGNHSINGEDVKISLH-DLKKKLYLCLMSVNALE 205
Cdd:PRK12759 197 ----------------------------ALLNDTLGLPDSEYHAFLEYKAMTDKIDFMMDADpTTRRGLGLCLAKTVFNE 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 206 AIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLLRNGQDDFefmqIAEECKQECFDLFKEAAEQEK 285
Cdd:PRK12759 249 GVALFASFAMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRIYCQENPYI----VDNEFKKEIYLMASKAVELED 324

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 515630954 286 EWAEYLFKDGSMIGLNKDILCQYVEYITNIRMQAVGLGTAYpAATSNPIPWINaWL 341
Cdd:PRK12759 325 RFIELAYELGTIEGLKADEVKQYIRHITDRRLNQLGLKEIY-NIEKNPLTWLE-WI 378
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 48-337 2.42e-12

ribonucleoside-diphosphate reductase


Pssm-ID: 215272  Cd Length: 324  Bit Score: 67.00  E-value: 2.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954  48 FWRPEEVDVSSDRIDYNKLPEHEKHiFISN-LKYQTLLDSIQGRSPNVALLPLVSLPEVETWietWSFS---ETIHSRSY 123
Cdd:PLN02492  32 FWTAEEVDLSADLKDWEKLTDDERH-FISHvLAFFAASDGIVLENLAARFMKEVQVPEARAF---YGFQiaiENIHSEMY 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 124 THIIRNIVNDPGV---VFDDIvENEEILKRAKDIAFyyddlikltadyhRYGEGNHSINGEdvkislhdlkkklylcLMS 200
Cdd:PLN02492 108 SLLLDTYIKDPKEkdrLFNAI-ETIPCVAKKADWAL-------------RWIDSSASFAER----------------LVA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515630954 201 VNALEAIRFYVSFACSFAFAERELMEGNAKIIKLIARDEALHLTGTQHMINLLRNgqddfefmQIAEECKQEcfdLFKEA 280
Cdd:PLN02492 158 FACVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLKN--------KLSEERVKE---IVCEA 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 515630954 281 AEQEKEW-AEYLfkDGSMIGLNKDILCQYVEYITNIRMQAVGLGTAYpaATSNPIPWI 337
Cdd:PLN02492 227 VEIEKEFvCDAL--PCALVGMNADLMSQYIEFVADRLLVALGYEKVY--NVVNPFDWM 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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