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Conserved domains on  [gi|515631650|ref|WP_017064250|]
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MULTISPECIES: Lpp/OprI family alanine-zipper lipoprotein [Vibrionaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lpp COG4238
Outer membrane murein-binding lipoprotein Lpp [Cell wall/membrane/envelope biogenesis];
1-88 6.68e-11

Outer membrane murein-binding lipoprotein Lpp [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443380 [Multi-domain]  Cd Length: 77  Bit Score: 53.05  E-value: 6.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515631650  1 MNK--TLIAAAASVFILAGCSSEPE-EAAVSEMDQLTNQVAQLTSEVEALKSDkaaaemkaqeaeaaAMAAKEEADRAND 77
Cdd:COG4238   1 MNRklLLGAAILSSLLLAGCSNNSKiDQLSSDVQSLNAKVDQLSNDVSALRAD--------------VQAAKEEAARANQ 66

                        90
                ....*....|.
gi 515631650 78 RIDNIAESYTK 88
Cdd:COG4238  67 RLDNQATSYKK 77
 
Name Accession Description Interval E-value
Lpp COG4238
Outer membrane murein-binding lipoprotein Lpp [Cell wall/membrane/envelope biogenesis];
1-88 6.68e-11

Outer membrane murein-binding lipoprotein Lpp [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443380 [Multi-domain]  Cd Length: 77  Bit Score: 53.05  E-value: 6.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515631650  1 MNK--TLIAAAASVFILAGCSSEPE-EAAVSEMDQLTNQVAQLTSEVEALKSDkaaaemkaqeaeaaAMAAKEEADRAND 77
Cdd:COG4238   1 MNRklLLGAAILSSLLLAGCSNNSKiDQLSSDVQSLNAKVDQLSNDVSALRAD--------------VQAAKEEAARANQ 66

                        90
                ....*....|.
gi 515631650 78 RIDNIAESYTK 88
Cdd:COG4238  67 RLDNQATSYKK 77
Ala_zip_lipo NF040598
Lpp/OprI family alanine-zipper lipoprotein; This model derives from PF11839 but is more ...
 4-88 1.07e-05

Lpp/OprI family alanine-zipper lipoprotein; This model derives from PF11839 but is more narrowly focused. All member sequences of the seed alignment are bacterial lipoproteins between 78 and 103 amino acids in length. Members include OprI (major outer membrane lipoprotein I) from Pseudomonas aeruginosa, and Lpp (Braun's lipoprotein), called the most abundant protein in Escherichia coli. Lpp becomes covalently linked to the cell wall, while anchored in the inner leaflet of the outer membrane, providing structural stability to the cell envelope.


Pssm-ID: 468572 [Multi-domain]  Cd Length: 90  Bit Score: 39.98  E-value: 1.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515631650  4 TLIAAAASVFILAGCSSEPE-EAAVSEMDQLTNQVAQLTSEVEALKSDKAAAEMKAQEAEAAAMAAKEEADRANDRIDNI 82
Cdd:NF040598  4 KLSALALSLALLAGCATTSDlENLQSQVQELDAKVDQASSDAAAAQSRADEAAAKAEQAEAAANAAQQEADEANERADRM 83


                ....*..
gi 515631650 83 AE-SYTK 88
Cdd:NF040598 84 FKkSMRK 90
LPP pfam04728
Lipoprotein leucine-zipper; This is leucine-zipper is found in the enterobacterial outer ...
 30-88 1.79e-04

Lipoprotein leucine-zipper; This is leucine-zipper is found in the enterobacterial outer membrane lipoprotein LPP. It is likely that this domain oligomerises and is involved in protein-protein interactions. As such it is a bundle of alpha-helical coiled-coils, which are known to play key roles in mediating specific protein-protein interactions for in molecular recognition and the assembly of multi-protein complexes.


Pssm-ID: 428092 [Multi-domain]  Cd Length: 53  Bit Score: 35.79  E-value: 1.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515631650  30 MDQLTNQVAQLTSEVEALKSDkaaaemkAQEAEAAAMAAKEEADRANDRIDNIAESYTK 88
Cdd:pfam04728  2 VDQLSSQVSSLKSKVDQLSSD-------VNSAKADVQAAKEEAARANQRLDNQASSYKK 53
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 1-37 7.65e-04

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 36.45  E-value: 7.65e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 515631650   1 MNKTLIAAAASVFILAGCSS---EPEEAAVSEMDQLTNQV 37
Cdd:PRK11138   3 LRKTLLPGLLSVTLLSGCSSfnsEEDVVKMSPLPQVENQF 42
 
Name Accession Description Interval E-value
Lpp COG4238
Outer membrane murein-binding lipoprotein Lpp [Cell wall/membrane/envelope biogenesis];
1-88 6.68e-11

Outer membrane murein-binding lipoprotein Lpp [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443380 [Multi-domain]  Cd Length: 77  Bit Score: 53.05  E-value: 6.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515631650  1 MNK--TLIAAAASVFILAGCSSEPE-EAAVSEMDQLTNQVAQLTSEVEALKSDkaaaemkaqeaeaaAMAAKEEADRAND 77
Cdd:COG4238   1 MNRklLLGAAILSSLLLAGCSNNSKiDQLSSDVQSLNAKVDQLSNDVSALRAD--------------VQAAKEEAARANQ 66

                        90
                ....*....|.
gi 515631650 78 RIDNIAESYTK 88
Cdd:COG4238  67 RLDNQATSYKK 77
Ala_zip_lipo NF040598
Lpp/OprI family alanine-zipper lipoprotein; This model derives from PF11839 but is more ...
 4-88 1.07e-05

Lpp/OprI family alanine-zipper lipoprotein; This model derives from PF11839 but is more narrowly focused. All member sequences of the seed alignment are bacterial lipoproteins between 78 and 103 amino acids in length. Members include OprI (major outer membrane lipoprotein I) from Pseudomonas aeruginosa, and Lpp (Braun's lipoprotein), called the most abundant protein in Escherichia coli. Lpp becomes covalently linked to the cell wall, while anchored in the inner leaflet of the outer membrane, providing structural stability to the cell envelope.


Pssm-ID: 468572 [Multi-domain]  Cd Length: 90  Bit Score: 39.98  E-value: 1.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515631650  4 TLIAAAASVFILAGCSSEPE-EAAVSEMDQLTNQVAQLTSEVEALKSDKAAAEMKAQEAEAAAMAAKEEADRANDRIDNI 82
Cdd:NF040598  4 KLSALALSLALLAGCATTSDlENLQSQVQELDAKVDQASSDAAAAQSRADEAAAKAEQAEAAANAAQQEADEANERADRM 83


                ....*..
gi 515631650 83 AE-SYTK 88
Cdd:NF040598 84 FKkSMRK 90
LPP pfam04728
Lipoprotein leucine-zipper; This is leucine-zipper is found in the enterobacterial outer ...
 30-88 1.79e-04

Lipoprotein leucine-zipper; This is leucine-zipper is found in the enterobacterial outer membrane lipoprotein LPP. It is likely that this domain oligomerises and is involved in protein-protein interactions. As such it is a bundle of alpha-helical coiled-coils, which are known to play key roles in mediating specific protein-protein interactions for in molecular recognition and the assembly of multi-protein complexes.


Pssm-ID: 428092 [Multi-domain]  Cd Length: 53  Bit Score: 35.79  E-value: 1.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515631650  30 MDQLTNQVAQLTSEVEALKSDkaaaemkAQEAEAAAMAAKEEADRANDRIDNIAESYTK 88
Cdd:pfam04728  2 VDQLSSQVSSLKSKVDQLSSD-------VNSAKADVQAAKEEAARANQRLDNQASSYKK 53
PRK11138 PRK11138
outer membrane biogenesis protein BamB; Provisional
 1-37 7.65e-04

outer membrane biogenesis protein BamB; Provisional


Pssm-ID: 236857 [Multi-domain]  Cd Length: 394  Bit Score: 36.45  E-value: 7.65e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 515631650   1 MNKTLIAAAASVFILAGCSS---EPEEAAVSEMDQLTNQV 37
Cdd:PRK11138   3 LRKTLLPGLLSVTLLSGCSSfnsEEDVVKMSPLPQVENQF 42
PRK15396 PRK15396
major outer membrane lipoprotein;
1-88 2.24e-03

major outer membrane lipoprotein;


Pssm-ID: 185294  Cd Length: 78  Bit Score: 33.71  E-value: 2.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515631650  1 MNKTLIAAAASVF---ILAGCSSEpeeaavSEMDQLTNQVAQLTSEVEALKSDKAAAEMKAQEAEAAAMaakeeadRAND 77
Cdd:PRK15396  1 MNRTKLVLGAVILgstLLAGCSSN------AKIDQLSSDVQTLNAKVDQLSNDVNAMRSDVQAAKDDAA-------RANQ 67

                        90
                ....*....|.
gi 515631650 78 RIDNIAESYTK 88
Cdd:PRK15396 68 RLDNQATKYRK 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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