|
Name |
Accession |
Description |
Interval |
E-value |
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-443 |
3.04e-107 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 325.32 E-value: 3.04e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 2 TTIKNRLNNRELISYFGYGVGQCFSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKF 81
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 82 RPYMLFTPFLIVLVTIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCAMLGVNAGI 161
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 162 GATLVIFPKLSAFFAdGRADQGYLPAVIVLMVAGLLFMLNGFYNTKERISTAScEKVTLKDTFQAVRKNKPLFFILAA-F 240
Cdd:COG2211 161 LLASVLPPPLVAAFG-GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-EKVSLKESLKALLKNRPFLLLLLAyL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 241 FMNVFFNLVNGLYIFFFTYNMGD-AGLVSLIGTITLVSAIAC-LATPILTKRFKKRDIFIALCVLEIIARVGFYLTGYDN 318
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVLGLsAALVGLLLALYFLAALLGaPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 319 TTVVMMWLAVVTGLFMMTNPLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPNADQT 398
Cdd:COG2211 319 LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQS 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 515636483 399 ETALNGMFFCIALLPALGALVRIFIMSRYTFTEDQHAILREKLER 443
Cdd:COG2211 399 PSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAA 443
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
14-431 |
3.67e-107 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 324.17 E-value: 3.67e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 14 ISYFGYGVGQCFSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIV 93
Cdd:cd17332 2 IGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 94 LVTIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCAMLGVNAGIGATLVIFPKLSA 173
Cdd:cd17332 82 LLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 174 FFADGRADQGYLPAVIVLMVAGLLFMLNGFYNTKERIS--TASCEKVTLKDTFQAVRKNKP-LFFILAAFFMNVFFNLVN 250
Cdd:cd17332 162 YFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVppEEEKSKLPLLKSLKALLKNRPfLILLLAYLLYFLAFNIVN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 251 GLYIFFFTYNMGDAG-LVSLIGTITLVSAIACLATPILTKRFKKRDIFIALCVLEIIARVGFYLTGYDNTTVVMMWLAVV 329
Cdd:cd17332 242 TVLVYYFKYVLGGRAeLVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 330 TGLFMMTNPLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPN-ADQTETALNGMFFC 408
Cdd:cd17332 322 GIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANaAAQSASALNGIRLL 401
|
410 420
....*....|....*....|...
gi 515636483 409 IALLPALGALVRIFIMSRYTFTE 431
Cdd:cd17332 402 IAVLPAVLLLLALILMSFYPLDK 424
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
17-442 |
1.69e-101 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 310.34 E-value: 1.69e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 17 FGYG---VGQCFSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIV 93
Cdd:TIGR00792 2 LSYGfgdFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 94 LVTIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCAMLGVNAGIGATLVIFPKLSA 173
Cdd:TIGR00792 82 IVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLVS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 174 FFADGRADQGYLPAVIVLMVAGLLFMLNGFYNTKERIST---ASCEKVTLKDTFQAVRKNKPLFFILAAFFM-NVFFNLV 249
Cdd:TIGR00792 162 YFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEipkNIEKKLSLKQIFKALFKNDQLLILCLAYLFyNLAFNIK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 250 NGLYIFFFTYNMGDAGLVSLIGTITLVSA-IACLATPILTKRFKKRDIFIALCVLEIIARVGFYLTGYdNTTVVMMWLAV 328
Cdd:TIGR00792 242 NGVQVYYFTYVLGDPELFSYMGSIAIVAGlIGVLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGS-NLPLILVLIIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 329 VTGLFMMTNPLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPNADQTETALNGMFFC 408
Cdd:TIGR00792 321 AGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAAQSPITLNGIKIL 400
|
410 420 430
....*....|....*....|....*....|....*
gi 515636483 409 IALLPALGALVRIFIMSR-YTFTEDQHAILREKLE 442
Cdd:TIGR00792 401 MFAVPALFLLLAAIIIGRfYKLTEKKHAEIVEELE 435
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
17-427 |
1.71e-64 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 215.35 E-value: 1.71e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 17 FGYG-VGQCFSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIVLV 95
Cdd:PRK10429 11 YGFGaFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWILIGTLANSVV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 96 TIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKaatcamlgvnagigatLVIFPKLSAFF 175
Cdd:PRK10429 91 LFLLFSAHLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQ----------------LVPYPRFFASL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 176 AD--------------GRADQGY-------LPAVIVLMVAGL-LFMLNGFYNTKErISTASCEKVTLKDTFQAVRKNKPL 233
Cdd:PRK10429 155 AGfvtagftlpfvnyvGGGDRGFgfqmftlVLIAFFIVSTIItLRNVHEVYSSDN-QVSAEGSHLTLKDIVALIYKNDQL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 234 FFILA-AFFMNVFFNLVNGLYIFFFTYNMGDAGLVSLIGT-ITLVSAIACLATPILTKRFKKRDIFIALCVLEIIARVGF 311
Cdd:PRK10429 234 SCLLGmALAYNIASNIINGFAIYYFTYVIGDADLFPYYLSyAGAANLVTLILFPRLVKSLSRRILWAGASIFPVLSCGVL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 312 YLTGY-DNTTVVMMWLAVV-----TGLFMMTNpliSAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLI 385
Cdd:PRK10429 314 LLMGLaAPHNALLIVIAGIllnigTALFWVLQ---VIMVADTVDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVV 390
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 515636483 386 LTTIGYVPNADQTETALNGMFFCIALLPALGALVRIFIMSRY 427
Cdd:PRK10429 391 LGLIGYVPNVEQSAQTLLGMQFIMIGLPTLFFMITLVLYFRY 432
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
29-431 |
3.17e-60 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 202.92 E-value: 3.17e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 29 LVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIVLVTIAAFYNIDADMS 108
Cdd:pfam13347 15 GLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILLFTPPELGRA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 109 TKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCAMLGVNAG-IGATLVIFPKLSAFFADGRADQGYLPA 187
Cdd:pfam13347 95 PLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGgLLAAALAFPLVLILGGTGLERKGYRIF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 188 VI---VLMVAGLLFMLNGFYNTKERIS---TASCEKVTLKDTFQAVRKNKPLFFILAAFFMNVF-FNLVNGLYIFFFTYN 260
Cdd:pfam13347 175 ALigaVLMLLGVIITAAGTKERVSMRSkedTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALaMGVLNGLLLYYFRYV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 261 MGDAGLVSLIGTITLVSAIacLATPI---LTKRFKKRDIFIALCVLEIIARVGFYLTGYDNTTVVMMWLAVVTGLFMMTN 337
Cdd:pfam13347 255 LGNGFAASAFPLVFTIGAL--LGIPLwppLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSF 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 338 PLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYV-PNADQTETALNGMFFCIALLPALG 416
Cdd:pfam13347 333 FLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNaGDSVQSPQAVTAIRLLYAVLPAVL 412
|
410
....*....|....*
gi 515636483 417 ALVRIFIMSRYTFTE 431
Cdd:pfam13347 413 FLVALLLLYFYPLDR 427
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
2-443 |
3.04e-107 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 325.32 E-value: 3.04e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 2 TTIKNRLNNRELISYFGYGVGQCFSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKF 81
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 82 RPYMLFTPFLIVLVTIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCAMLGVNAGI 161
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 162 GATLVIFPKLSAFFAdGRADQGYLPAVIVLMVAGLLFMLNGFYNTKERISTAScEKVTLKDTFQAVRKNKPLFFILAA-F 240
Cdd:COG2211 161 LLASVLPPPLVAAFG-GDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-EKVSLKESLKALLKNRPFLLLLLAyL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 241 FMNVFFNLVNGLYIFFFTYNMGD-AGLVSLIGTITLVSAIAC-LATPILTKRFKKRDIFIALCVLEIIARVGFYLTGYDN 318
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVLGLsAALVGLLLALYFLAALLGaPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGN 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 319 TTVVMMWLAVVTGLFMMTNPLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPNADQT 398
Cdd:COG2211 319 LWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQS 398
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 515636483 399 ETALNGMFFCIALLPALGALVRIFIMSRYTFTEDQHAILREKLER 443
Cdd:COG2211 399 PSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAA 443
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
14-431 |
3.67e-107 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 324.17 E-value: 3.67e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 14 ISYFGYGVGQCFSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIV 93
Cdd:cd17332 2 IGYGLGDFGNNLIFQIVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 94 LVTIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCAMLGVNAGIGATLVIFPKLSA 173
Cdd:cd17332 82 LLFVLLFTTPDGSGTGKLIYALITYILLDLLYTLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 174 FFADGRADQGYLPAVIVLMVAGLLFMLNGFYNTKERIS--TASCEKVTLKDTFQAVRKNKP-LFFILAAFFMNVFFNLVN 250
Cdd:cd17332 162 YFGGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVppEEEKSKLPLLKSLKALLKNRPfLILLLAYLLYFLAFNIVN 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 251 GLYIFFFTYNMGDAG-LVSLIGTITLVSAIACLATPILTKRFKKRDIFIALCVLEIIARVGFYLTGYDNTTVVMMWLAVV 329
Cdd:cd17332 242 TVLVYYFKYVLGGRAeLVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 330 TGLFMMTNPLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPN-ADQTETALNGMFFC 408
Cdd:cd17332 322 GIGYGGANLLPWAMLADVIDYGELKTGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANaAAQSASALNGIRLL 401
|
410 420
....*....|....*....|...
gi 515636483 409 IALLPALGALVRIFIMSRYTFTE 431
Cdd:cd17332 402 IAVLPAVLLLLALILMSFYPLDK 424
|
|
| gph |
TIGR00792 |
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ... |
17-442 |
1.69e-101 |
|
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273270 Cd Length: 437 Bit Score: 310.34 E-value: 1.69e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 17 FGYG---VGQCFSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIV 93
Cdd:TIGR00792 2 LSYGfgdFGNDFIFAIVSTYLLFFYTDVLGLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLLIGAIPFS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 94 LVTIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCAMLGVNAGIGATLVIFPKLSA 173
Cdd:TIGR00792 82 IVLVLLFTTPDFSGTGKLVYAYITYILLGLFYSFVNIPYWSLVPAITLDPRERESLSTFRRFGATLGGLLVAVIVLPLVS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 174 FFADGRADQGYLPAVIVLMVAGLLFMLNGFYNTKERIST---ASCEKVTLKDTFQAVRKNKPLFFILAAFFM-NVFFNLV 249
Cdd:TIGR00792 162 YFGGGDDKFGWFMFALVLALIGVVSLIICFFGTKERYSEipkNIEKKLSLKQIFKALFKNDQLLILCLAYLFyNLAFNIK 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 250 NGLYIFFFTYNMGDAGLVSLIGTITLVSA-IACLATPILTKRFKKRDIFIALCVLEIIARVGFYLTGYdNTTVVMMWLAV 328
Cdd:TIGR00792 242 NGVQVYYFTYVLGDPELFSYMGSIAIVAGlIGVLLFPRLVKKFGRKILFAGGILLMVLGYLIFFFAGS-NLPLILVLIIL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 329 VTGLFMMTNPLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPNADQTETALNGMFFC 408
Cdd:TIGR00792 321 AGFGQNIVTGLVWALVADTVDYGEWKTGIRAEGLVYSVRTFVRKLGQALAGFFVGLILGIIGYVANAAQSPITLNGIKIL 400
|
410 420 430
....*....|....*....|....*....|....*
gi 515636483 409 IALLPALGALVRIFIMSR-YTFTEDQHAILREKLE 442
Cdd:TIGR00792 401 MFAVPALFLLLAAIIIGRfYKLTEKKHAEIVEELE 435
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
17-427 |
1.71e-64 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 215.35 E-value: 1.71e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 17 FGYG-VGQCFSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIVLV 95
Cdd:PRK10429 11 YGFGaFGKDFAIGIVYMYLMYYYTDVVGLSVGLVGTLFLVARIWDAINDPIMGWIVNNTRSRWGKFKPWILIGTLANSVV 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 96 TIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKaatcamlgvnagigatLVIFPKLSAFF 175
Cdd:PRK10429 91 LFLLFSAHLFEGTAQYVFVCVTYILWGMTYTIMDIPFWSLVPTLTLDKREREQ----------------LVPYPRFFASL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 176 AD--------------GRADQGY-------LPAVIVLMVAGL-LFMLNGFYNTKErISTASCEKVTLKDTFQAVRKNKPL 233
Cdd:PRK10429 155 AGfvtagftlpfvnyvGGGDRGFgfqmftlVLIAFFIVSTIItLRNVHEVYSSDN-QVSAEGSHLTLKDIVALIYKNDQL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 234 FFILA-AFFMNVFFNLVNGLYIFFFTYNMGDAGLVSLIGT-ITLVSAIACLATPILTKRFKKRDIFIALCVLEIIARVGF 311
Cdd:PRK10429 234 SCLLGmALAYNIASNIINGFAIYYFTYVIGDADLFPYYLSyAGAANLVTLILFPRLVKSLSRRILWAGASIFPVLSCGVL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 312 YLTGY-DNTTVVMMWLAVV-----TGLFMMTNpliSAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLI 385
Cdd:PRK10429 314 LLMGLaAPHNALLIVIAGIllnigTALFWVLQ---VIMVADTVDYGEYKLGIRCESIAYSVQTMVVKGGSAFAAFFIGVV 390
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 515636483 386 LTTIGYVPNADQTETALNGMFFCIALLPALGALVRIFIMSRY 427
Cdd:PRK10429 391 LGLIGYVPNVEQSAQTLLGMQFIMIGLPTLFFMITLVLYFRY 432
|
|
| PRK09848 |
PRK09848 |
glucuronide transporter; Provisional |
18-443 |
4.17e-63 |
|
glucuronide transporter; Provisional
Pssm-ID: 182109 [Multi-domain] Cd Length: 448 Bit Score: 211.18 E-value: 4.17e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 18 GYGVGQC---FSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIVL 94
Cdd:PRK09848 12 GYSLGDVannFAFAMGALFLLSYYTDVAGVGAAAAGTMLLLVRVFDAFADVFAGRVVDSVNTRWGKFRPFLLFGTAPLMI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 95 VTIAAFY-NIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKaatcamLGVNAGIGATL-------V 166
Cdd:PRK09848 92 FSVLVFWvPTDWSHSSKVVYAYLTYMGLGLCYSLVNIPYGSLATAMTQQPQSRAR------LGAARGIAASLtfvclafL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 167 IFPKLSAFFADGRADQgYLPAVIVLMVAGLLFMLNGFYNTKERISTaSCEKVTLKDTFQAVRKNKPLFFI-LAAFFMNVF 245
Cdd:PRK09848 166 IGPSIKNSSPEEMVSV-YHFWTIVLAIAGMVLYFICFKSTRENVVR-IVAQPSLKISLQTLKRNRPLFMLcIGALCVLIS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 246 FNLVNGLYIFFFTYNMGDAGL-VSLIGTITLVSAIACLA-TPILTKRFKKRDIFIALCVLEIIARVGFYLTGYDNTTVVM 323
Cdd:PRK09848 244 TFAVSASSLFYVRYVLNDTGLfTVLVLVQNLVGTVASAPlVPGMVARIGKKNTFLIGALLGTCGYLLFFWVSVWSLPVAL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 324 MWLAVVTGLFMMTNPLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPNADQTETALN 403
Cdd:PRK09848 324 VALAIASIGQGVTMTVMWALEADTVEYGEYLTGVRIEGLTYSLFSFTRKCGQAIGGSIPAFILGLSGYIANQVQTPEVIM 403
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 515636483 404 GMFFCIALLPALGALVRIFIMSRYTFTEDQHA-ILREKLER 443
Cdd:PRK09848 404 GIRTSIALVPCGFMLLAFVIIWFYPLTDKKFKeIVVEIDNR 444
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
29-431 |
3.17e-60 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 202.92 E-value: 3.17e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 29 LVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIVLVTIAAFYNIDADMS 108
Cdd:pfam13347 15 GLATYLLYFYTDVLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAVSFILLFTPPELGRA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 109 TKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCAMLGVNAG-IGATLVIFPKLSAFFADGRADQGYLPA 187
Cdd:pfam13347 95 PLFIWLLATYILLRIAYTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGgLLAAALAFPLVLILGGTGLERKGYRIF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 188 VI---VLMVAGLLFMLNGFYNTKERIS---TASCEKVTLKDTFQAVRKNKPLFFILAAFFMNVF-FNLVNGLYIFFFTYN 260
Cdd:pfam13347 175 ALigaVLMLLGVIITAAGTKERVSMRSkedTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALaMGVLNGLLLYYFRYV 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 261 MGDAGLVSLIGTITLVSAIacLATPI---LTKRFKKRDIFIALCVLEIIARVGFYLTGYDNTTVVMMWLAVVTGLFMMTN 337
Cdd:pfam13347 255 LGNGFAASAFPLVFTIGAL--LGIPLwppLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSF 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 338 PLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYV-PNADQTETALNGMFFCIALLPALG 416
Cdd:pfam13347 333 FLPWSMLADVVDYGELRTGKRREGTFFAMWSFISKLATGVGLGVSGLLLSAFGYNaGDSVQSPQAVTAIRLLYAVLPAVL 412
|
410
....*....|....*
gi 515636483 417 ALVRIFIMSRYTFTE 431
Cdd:pfam13347 413 FLVALLLLYFYPLDR 427
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
3-430 |
2.06e-47 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 169.14 E-value: 2.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 3 TIKNRLNNRELISYfGYGVGQC-FSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKF 81
Cdd:PRK09669 1 MNTSQLTTKDKIGY-GLGDTACnLVWQTVMLFLAYFYTDVFGLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 82 RPYMLFTPFLIVLVTIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAAT----CAMLGv 157
Cdd:PRK09669 80 RPYLLWFAIPFGVVCLLTFYTPDFGATGKIIYACVTYILLSLVYTAINVPYCAMPGAITNDPRERHSLQSwrfaLSFIG- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 158 naGIGATLVIFPkLSAFFADGRADQGYLPAVIVLMVAGLLFMLNGFYNTKERISTASCEKVTLKDTFQAVRKNKPLFFIL 237
Cdd:PRK09669 159 --GLIVSVIALP-LVDILGKGDEQKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSSSVWKDLKLLLGNSQWRIMF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 238 AAFFMNVFFNLVNG-LYIFFFTYNMGDAGLVSLIGTITLVSA-IACLATPILTKRFKKRDIFIALCVLEIIARVGFYLTG 315
Cdd:PRK09669 236 IFNVVLLTAVVTRGgATLYYVNYVLLRPDLATLFLVTGMIAGlFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIP 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 316 YDNTTVVMMWLAVVTGLFMMTNPLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPNA 395
Cdd:PRK09669 316 PSNVWLIFALNILFNFIQNLTTPLQWSMFSDVVDYEEKRSGRRLDGLVFSTNLFAIKLGLAIGGAVVGWILAWVDYVGGA 395
|
410 420 430
....*....|....*....|....*....|....*.
gi 515636483 396 D-QTETALNGMFFCIALLPALGALVRIFIMSRYTFT 430
Cdd:PRK09669 396 AvQSASVLTTINLLFTVIPGVLFAGMAIILNFYKLN 431
|
|
| PRK11462 |
PRK11462 |
putative transporter; Provisional |
18-427 |
3.50e-45 |
|
putative transporter; Provisional
Pssm-ID: 183145 Cd Length: 460 Bit Score: 163.57 E-value: 3.50e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 18 GYGVGQCFS---FGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDTLESRFGKFRPYMLFTPFLIVL 94
Cdd:PRK11462 13 GYGMGDAAShiiFDNVMLYMMFFYTDIFGIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLFGALPFGI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 95 VTIAAFYNIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCA-MLGVNAGIGATLVIFPKLSA 173
Cdd:PRK11462 93 VCVLAYSTPDLSMNGKMIYAAITYTLLTLLYTVVNIPYCALGGVITNDPTQRISLQSWRfVLATAGGMLSTVLMMPLVNL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 174 FFADGRAdQGYLPAVIVLMVAGLLFMLNGFYNTKERIStASCEKVTLKDTFQAVRKNKPLFFILAAFFMNVFFNLV-NGL 252
Cdd:PRK11462 173 IGGDNKP-LGFQGGIAVLSVVAFMMLAFCFFTTKERVE-APPTTTSMREDLRDIWQNDQWRIVGLLTIFNILAVCVrGGA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 253 YIFFFTYNMGDAGLVSLIGTITLVSAI--ACLATPiLTKRFKKRDIFIALCVLEIIARVGFYLTGYDNTTVVMMWLAVVT 330
Cdd:PRK11462 251 MMYYVTWILGTPEVFVAFLTTYCVGNLigSALAKP-LTDWKCKVTIFWWTNALLAVISLAMFFVPMQASITMFVFIFVIG 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 331 GLFMMTNPLISAMIADTVEYSYYHSGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPNAD-QTETALNGMFFCI 409
Cdd:PRK11462 330 VLHQLVTPIQWVMMSDTVDYGEWCNGKRLTGISFAGTLFVLKLGLAFGGALIGWMLAYGGYDAAEKaQNSATISIIIALF 409
|
410
....*....|....*...
gi 515636483 410 ALLPALGALVRIFIMSRY 427
Cdd:PRK11462 410 TIVPAICYLLSAIIAKRY 427
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
30-395 |
1.17e-15 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 78.67 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 30 VGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIaGYM--DTLESRFGKFRPYMLFTPFLIVLVTIAAFYnIDADM 107
Cdd:cd17392 18 TGFFLQIFLLDVAQMGAFSVSLILFVGRVWDAVTDPLV-GYFisRSQRTGIGRLMPWIVFSTPLIILAYFFLWF-LPPFT 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 108 STKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAA----TCAMLGVNAGI---GATLVIFPK---LSAFFAD 177
Cdd:cd17392 96 SLSGLWYLTFYCLFETFMTCFHVPYSALTMFLGGCQRERDSATayrmTVEVFGTLMGAtiqGQIVGVAHRprrQDCTATP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 178 GRADQG----------YLPAVIVLMVAGLLFMLNGFYNTKER---ISTASCEKVTLKDTFQAVRKNKP-LFFILAAFFMN 243
Cdd:cd17392 176 GTSDHPvtvlpntrraYLIAALVVVVLYFVCCSILFLGVKEQpdpLSPASGPGLSYLAGLKLVTGHPPyLKLVIGFLFSS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 244 VFFNLVNGLYIFFFTYNMGDAGLVSLIGTITLVSAIacLATPI----LTKRFKKRDIFIALCVLEIIARVgfyLTGYDNT 319
Cdd:cd17392 256 LAFQMEQGNFVLFCTHAAGLGDHFQHLVLAILVSAT--LSIPLwqwvLQRRGKKTTSFIGISAMVPFLIL---LALVPSN 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515636483 320 TVVMMWLAVVTGLFMMTNPLIS-AMIADTV-EYSYYH-SGKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPNA 395
Cdd:cd17392 331 LPVAYVVAVVSGVSLAALFLLPwSMLPDVVdDFQLKNpHCPGLEPIFYSCYVFFTKLGGGLSLGISTLSLHFSGYKAGA 409
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
24-431 |
2.97e-12 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 68.31 E-value: 2.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 24 CFSFG-----LVGS----FILYFYTDILGISPIAASTIFLIARVWDAVNDPlIAGYMDTLE--SRFGKFRPYML-FTPFL 91
Cdd:cd17452 3 CYAIGgapnqVAGSatafFLQIYLLDIAQITPFQASLVLFVGKAWGAATDP-VVGFFISKSkwTKIGRLMPWMLgCTPFI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 92 IVLVTIAAFynIDADMSTKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAATCAMlgvnagigaTLVIFPKL 171
Cdd:cd17452 82 VVSYFFLWF--VPPFTTGRFLWYLTFYCLFQALATCFHVPYSALTMFLSTDQRERDSATAYRM---------TVEVLGTL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 172 SAFFADGR-ADQGYLPAVIVLMVAGLLFMLNGFYNTKER---ISTASCEKVTLKDTFQAVRKNKPLFFILAAF-FMNVFF 246
Cdd:cd17452 151 VGAAVQGQiVASAYMIAAGVIGGLYLLCISVLFLGVKERddpYAPKSGKAIPFFKGLSLTMRHGPYLKLTASFlFISAAV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 247 NLVNGLYIFFFTYNMGDAGLVSLIGTITLVSAIacLATPI---LTKRFKKRdifIALCVLEIIARVGFYLTGYDNTTVVM 323
Cdd:cd17452 231 QLEQSNFVLFCTHAVDLHDHFQNLVLTILVSAV--VSIPFwqwFLQRFGKK---AAACGISWMIPFAIMLVTIPNLIVAY 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 324 MwLAVVTGLFMMTNPLIS-AMIADTVEYSYYHS--GKRTAAITFSGQTFTGKLSVAVAGGLTGLILTTIGYVPNA-DQTE 399
Cdd:cd17452 306 V-VAFVSGLSIAASLLLPwSMLPDVVDDFRLQNphGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYETGAcKQPE 384
|
410 420 430
....*....|....*....|....*....|..
gi 515636483 400 TALNGMFFCIALLPALGALVRIFIMSRYTFTE 431
Cdd:cd17452 385 SVVLTLKLLIGAAPTCMILIGLCILMFYPITE 416
|
|
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
30-262 |
1.57e-10 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 62.91 E-value: 1.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 30 VGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMD-TLESRFGKFRPYMLFTPFLIVLVTIAAFYNIDADMS 108
Cdd:cd17451 18 LGFFLQIYLLDVAQLDPFYASIILFVGRAWDAITDPTVGFFVSkSPWTRFGRLMPWIIFSTPFAVLSYFLIWFVPDFSQG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 109 tKVMYAGITYILWGTLYTISDVPFWSMSSVMTDEPQERAKAA----TCAMLGVNAGIGATLVIFPKLSAFFADGRADQGY 184
Cdd:cd17451 98 -KVMWYLLFYCLFQTLQTCFHVPYSALTMFISTEQKERDSATayrmTVEVLGTVLGTAIQGQIVGMAAYMIAAGVICAIY 176
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515636483 185 LPAVIVLMVagllfmlnGFYNTKERISTASCEKVTLKDTFQAVRKNKPLFFILAAF-FMNVFFNLVNGLYIFFFTYNMG 262
Cdd:cd17451 177 VLCAIILFL--------GVREQREPCELKSQKPVSFFKGLKLVMSHGPYIKLITGFlFTSLAFMLLEGNFALFCTYTLG 247
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-348 |
2.61e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.26 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 24 CFSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNDPLIAGYMDtlesRFGKfRPYMLFTPFLIVLVTIAAFYNI 103
Cdd:pfam07690 9 ALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD----RFGR-RRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 104 DADMstkvmyagitYILWGTLYTISDVPFWSMSSVMTDE---PQERAKAATCAMLGVNAGIGATLVIFPKLSAFFadgRA 180
Cdd:pfam07690 84 SLWL----------LLVLRVLQGLGAGALFPAALALIADwfpPEERGRALGLVSAGFGLGAALGPLLGGLLASLF---GW 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 181 DQGYLPAVIVLMVAGLLFMLNGFYNTKERISTASCEKVTLKDTFQAVRKNKPLFFILAAFFMNVFFNLVNG-LYIFFFTY 259
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTyLPLYQEVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 260 NMGDAGLVSLIGTITLVSAIACLATPILTKRFKKRDIFIALCVLEIIARVGFYLTGYDNTTVVMMWLAVVTGLFM-MTNP 338
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFgLVFP 310
|
330
....*....|
gi 515636483 339 LISAMIADTV 348
Cdd:pfam07690 311 ALNALVSDLA 320
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
143-426 |
1.76e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.71 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 143 PQERAKAATCAMLGVNAGIGATLVIFPKLSAFFadgradqGYLPAVIVLMVAGLLFMlngfyntkeristascekvtlkd 222
Cdd:COG2271 129 PKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-------GWRAAFLILGLPGLLLA----------------------- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 223 tfqavrknkpLFFILAAFFMNVFFNLVNGLYIFFFT--------YNMGDAGLVSLIgtITLVSAIACLATPILTKRFKKR 294
Cdd:COG2271 179 ----------LLRFWLLALAYFLVYFALYGFLTWLPtylvevrgLSLAQAGLLLSL--PFLAGIVGSLLGGWLSDRLGRR 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 295 DIFIALCVLeIIARVGFYLTGYDNTTVVMMWLAVVTGLFM-MTNPLISAMIADTVeysyyhsGKRTAAITFSGQTFTGKL 373
Cdd:COG2271 247 RKLVLAIGL-LLAALALLLLALLPSPALAIALLFLAGFGLgGAFGLLWALAAELF-------PKKARGTASGLVNTFGFL 318
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 515636483 374 SVAVAGGLTGLILTTIGYvpnadqtetalNGMFFCIALLPALGALVRIFIMSR 426
Cdd:COG2271 319 GGALGPLLVGYLLDATGY-----------QAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
133-419 |
1.85e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 40.59 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 133 WSMSSVMTDE---PQERAKAATCAMLGVNAG-IGATLVIFPKLSAFFADGRADQGY-LP--AVIVLMVAGLLFMLN---- 201
Cdd:cd17369 123 WGGAVLMAVEhapPKRRGFYGSFPQLGAPVGlLLATGVFLLLSALLSDEAFLSWGWrIPflLSAVLVAVGLYIRLRleet 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 202 -GFYNTKERistascEKVTLKDTFQAVRKNKPLFF--ILAAFFMNVFFNLVNGLYIFFFTYNMGDAGLVSLIGtITLVSA 278
Cdd:cd17369 203 pVFRRAKEA------GQVVRAPLVEVLRRHWRALLlaIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLA-VLIASV 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 279 IACLATPI---LTKRFKKRDIFIALCVLEIIARVGFYLTGYDNTTVVMMWLAVVTG--LFMMTNPLISAMIADTVEysyy 353
Cdd:cd17369 276 VAAITIPLfgwLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLgvLHGMMYGPQAAFLAELFP---- 351
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515636483 354 hsgkrtAAITFSGQTFTGKLSVAVAGGLTGLILTTIGyvpNADQTETALNGMFFCIALLPALGALV 419
Cdd:cd17369 352 ------TRVRYTGASLGYQLGAILGGGFAPLIATALV---AATGSWWPVALYLAALAVISLVAALF 408
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
25-346 |
8.13e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.36 E-value: 8.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 25 FSFGLVGSFILYFYTDILGISPIAASTIFLIARVWDAVNdPLIAGYmdtLESRFGKfRPYMLFTPFLIVLVTIAAFynid 104
Cdd:cd17329 13 LGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVA-SLIGGR---LADRFGR-KPVMLAGLLLRALGFALLG---- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 105 admstkVMYAGITYILWGTLYTI-SDVPFWSMSSVMTD--EPQERAKAATCAMLGVNAGIgatlVIFPKLSAFFadgrAD 181
Cdd:cd17329 84 ------FAHSPWLFAIALVLTGFgGGLFEPASEAMIADvtTPENRTRAFSLLYWAINLGV----AIGPLLGGLL----LL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 182 QGYLPAVIVLMVAGLLFMLNGFYNTKERIST-ASCEKVTLKDTFQAVRKNKPLFFILAAFFmnVFFNLVNGLYIFFFTYN 260
Cdd:cd17329 150 YSFRLLFLAAAVLFLLAALVLLFLLPETRPKrRAAEKTEILRGYKIVLRDRAFLLFLLASF--LISLIYFQLESTLPVYV 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515636483 261 MGDAGL-VSLIGTITLVSAIA-CLATPILTKRFKKRDIFIALCVLEIIARVGFYLTGYDNTtvvMMWLAVVTGLF----M 334
Cdd:cd17329 228 VEILGLgESLLGLLLALNALLiVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANT---LAVLILAMIVLtlgeM 304
|
330
....*....|..
gi 515636483 335 MTNPLISAMIAD 346
Cdd:cd17329 305 LVFPAVQTLVAA 316
|
|
| |
