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Conserved domains on  [gi|515639723|ref|WP_017072323|]
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MULTISPECIES: fumarylacetoacetate hydrolase family protein [Vibrio]

Protein Classification

fumarylacetoacetate hydrolase family protein( domain architecture ID 11415096)

fumarylacetoacetate (FAA) hydrolase family protein belongs to the FAA hydrolase family which includes a large variety of metabolic enzymes, including those with hydrolase functions involved in the breakdown of aromatic compounds, oxaloacetate decarboxylase, and enzymes associated with other catabolic pathways including decarboxylation of substrates other than oxaloacetate, hydration, isomerization and hydroxylation reactions

CATH:  2.30.30.370
Gene Ontology:  GO:0003824|GO:0016787
PubMed:  29487229
SCOP:  4002580

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FAA_hydro_N_2 pfam18288
Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of ...
 1-84 4.79e-39

Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of Fumarylacetoacetate (FAA) hydrolase (pfam01557). Family members of this domain include Pseudogulbenkiania ferrooxidans and Cupriavidus gilardii.


:

Pssm-ID: 436386  Cd Length: 78  Bit Score: 133.15  E-value: 4.79e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723    1 MKLATKKNGTRDGLLMVVSKDLKQCVAATEIfhamhlAPTMQVALDNWDSVASQLQELYTSLNNGHVTGSEVFASQYCES 80
Cdd:pfam18288   1 MKLATLKNGTRDGQLVVVSRDLTRAVPAPAI------APTLQAALENWSAVEPALQELYTALNAGTAKDGFPFDPAKCMA 74


                  ....
gi 515639723   81 PLPR 84
Cdd:pfam18288  75 PLPR 78
FAA_hydrolase pfam01557
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ...
 88-281 1.69e-38

Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.


:

Pssm-ID: 460252  Cd Length: 210  Bit Score: 136.26  E-value: 1.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723   88 WADGSAYVNHVELVRKArgaeMPESFWVDPL-MYQGGSDAFIGPCDNIEFASDGWGIDFEGEVAIVTGDVPMGASAKQAH 166
Cdd:pfam01557   1 VCVGLNYAEHAREAGKA----EPVPDFPIPLvLFVKPPSSLIGPGDPIVRPAGVTKLDYEAELAVVIGRPARDVSPEEAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723  167 DSIRLLMLVNDVSLRGLIPAELAKGFGFFQSKPSSA-FSPVAVTPDELGEqWKGskvhLPLISTYNDQPFGCPNAGvDMT 245
Cdd:pfam01557  77 DYIFGYTLANDVSARDLQRREMPLQWFRGKSFDGFTpLGPWIVTRDELPD-PGD----LRLRLRVNGEVRQDGNTS-DMI 150

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 515639723  246 FNFAELVVHAAKTRPLSAGAIIGSGTVSNKQGTDHG 281
Cdd:pfam01557 151 FSPAELIAHLSQFMTLRPGDIILTGTPSGVGAGRAP 186
 
Name Accession Description Interval E-value
FAA_hydro_N_2 pfam18288
Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of ...
 1-84 4.79e-39

Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of Fumarylacetoacetate (FAA) hydrolase (pfam01557). Family members of this domain include Pseudogulbenkiania ferrooxidans and Cupriavidus gilardii.


Pssm-ID: 436386  Cd Length: 78  Bit Score: 133.15  E-value: 4.79e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723    1 MKLATKKNGTRDGLLMVVSKDLKQCVAATEIfhamhlAPTMQVALDNWDSVASQLQELYTSLNNGHVTGSEVFASQYCES 80
Cdd:pfam18288   1 MKLATLKNGTRDGQLVVVSRDLTRAVPAPAI------APTLQAALENWSAVEPALQELYTALNAGTAKDGFPFDPAKCMA 74


                  ....
gi 515639723   81 PLPR 84
Cdd:pfam18288  75 PLPR 78
FAA_hydrolase pfam01557
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ...
 88-281 1.69e-38

Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.


Pssm-ID: 460252  Cd Length: 210  Bit Score: 136.26  E-value: 1.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723   88 WADGSAYVNHVELVRKArgaeMPESFWVDPL-MYQGGSDAFIGPCDNIEFASDGWGIDFEGEVAIVTGDVPMGASAKQAH 166
Cdd:pfam01557   1 VCVGLNYAEHAREAGKA----EPVPDFPIPLvLFVKPPSSLIGPGDPIVRPAGVTKLDYEAELAVVIGRPARDVSPEEAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723  167 DSIRLLMLVNDVSLRGLIPAELAKGFGFFQSKPSSA-FSPVAVTPDELGEqWKGskvhLPLISTYNDQPFGCPNAGvDMT 245
Cdd:pfam01557  77 DYIFGYTLANDVSARDLQRREMPLQWFRGKSFDGFTpLGPWIVTRDELPD-PGD----LRLRLRVNGEVRQDGNTS-DMI 150

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 515639723  246 FNFAELVVHAAKTRPLSAGAIIGSGTVSNKQGTDHG 281
Cdd:pfam01557 151 FSPAELIAHLSQFMTLRPGDIILTGTPSGVGAGRAP 186
YcgM COG0179
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) ...
 94-271 9.12e-12

2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439949  Cd Length: 206  Bit Score: 63.55  E-value: 9.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723  94 YVNHV-ELvrkarGAEMPEsfwvDPLMYQGGSDAFIGPCDNIEFASDGWGIDFEGEVAIVTGDVPMGASAKQAHDSIRLL 172
Cdd:COG0179   15 YADHAaEM-----GNDVPE----EPVLFLKPPSALVGPGDPIPLPAGSGKLDYEGELAVVIGKRARNVSEEDALDHVAGY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723 173 MLVNDVSLRGLI-----PAELAKGFgffqskPSSA-FSPVAVTPDELGEqwkgskVH-LPLISTYNDQPfgcpnagV--- 242
Cdd:COG0179   86 TVANDVTARDLQrerggQWTRGKSF------DTFCpLGPWIVTADEIPD------PQdLRIRLRVNGEV-------Rqdg 146

                        170       180       190
                 ....*....|....*....|....*....|..
gi 515639723 243 ---DMTFNFAELVVHAAKTRPLSAGAIIGSGT 271
Cdd:COG0179  147 ntsDMIFSVAELIAYLSQFMTLEPGDVILTGT 178
 
Name Accession Description Interval E-value
FAA_hydro_N_2 pfam18288
Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of ...
 1-84 4.79e-39

Fumarylacetoacetase N-terminal domain 2; This is domain is found in the N-terminal region of Fumarylacetoacetate (FAA) hydrolase (pfam01557). Family members of this domain include Pseudogulbenkiania ferrooxidans and Cupriavidus gilardii.


Pssm-ID: 436386  Cd Length: 78  Bit Score: 133.15  E-value: 4.79e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723    1 MKLATKKNGTRDGLLMVVSKDLKQCVAATEIfhamhlAPTMQVALDNWDSVASQLQELYTSLNNGHVTGSEVFASQYCES 80
Cdd:pfam18288   1 MKLATLKNGTRDGQLVVVSRDLTRAVPAPAI------APTLQAALENWSAVEPALQELYTALNAGTAKDGFPFDPAKCMA 74


                  ....
gi 515639723   81 PLPR 84
Cdd:pfam18288  75 PLPR 78
FAA_hydrolase pfam01557
Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) ...
 88-281 1.69e-38

Fumarylacetoacetate (FAA) hydrolase family; This family consists of fumarylacetoacetate (FAA) hydrolase, or fumarylacetoacetate hydrolase (FAH) and it also includes HHDD isomerase/OPET decarboxylase from E. coli strain W. FAA is the last enzyme in the tyrosine catabolic pathway, it hydrolyses fumarylacetoacetate into fumarate and acetoacetate which then join the citric acid cycle. Mutations in FAA cause type I tyrosinemia in humans this is an inherited disorder mainly affecting the liver leading to liver cirrhosis, hepatocellular carcinoma, renal tubular damages and neurologic crises amongst other symptoms. The enzymatic defect causes the toxic accumulation of phenylalanine/tyrosine catabolites. The E. coli W enzyme HHDD isomerase/OPET decarboxylase contains two copies of this domain and functions in fourth and fifth steps of the homoprotocatechuate pathway; here it decarboxylates OPET to HHDD and isomerizes this to OHED. The final products of this pathway are pyruvic acid and succinic semialdehyde. This family also includes various hydratases and 4-oxalocrotonate decarboxylases which are involved in the bacterial meta-cleavage pathways for degradation of aromatic compounds. 2-hydroxypentadienoic acid hydratase encoded by mhpD in E. coli is involved in the phenylpropionic acid pathway of E. coli and catalyzes the conversion of 2-hydroxy pentadienoate to 4-hydroxy-2-keto-pentanoate and uses a Mn2+ co-factor. OHED hydratase encoded by hpcG in E. coli is involved in the homoprotocatechuic acid (HPC) catabolism. XylI in P. putida is a 4-Oxalocrotonate decarboxylase.


Pssm-ID: 460252  Cd Length: 210  Bit Score: 136.26  E-value: 1.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723   88 WADGSAYVNHVELVRKArgaeMPESFWVDPL-MYQGGSDAFIGPCDNIEFASDGWGIDFEGEVAIVTGDVPMGASAKQAH 166
Cdd:pfam01557   1 VCVGLNYAEHAREAGKA----EPVPDFPIPLvLFVKPPSSLIGPGDPIVRPAGVTKLDYEAELAVVIGRPARDVSPEEAL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723  167 DSIRLLMLVNDVSLRGLIPAELAKGFGFFQSKPSSA-FSPVAVTPDELGEqWKGskvhLPLISTYNDQPFGCPNAGvDMT 245
Cdd:pfam01557  77 DYIFGYTLANDVSARDLQRREMPLQWFRGKSFDGFTpLGPWIVTRDELPD-PGD----LRLRLRVNGEVRQDGNTS-DMI 150

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 515639723  246 FNFAELVVHAAKTRPLSAGAIIGSGTVSNKQGTDHG 281
Cdd:pfam01557 151 FSPAELIAHLSQFMTLRPGDIILTGTPSGVGAGRAP 186
YcgM COG0179
2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) ...
 94-271 9.12e-12

2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439949  Cd Length: 206  Bit Score: 63.55  E-value: 9.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723  94 YVNHV-ELvrkarGAEMPEsfwvDPLMYQGGSDAFIGPCDNIEFASDGWGIDFEGEVAIVTGDVPMGASAKQAHDSIRLL 172
Cdd:COG0179   15 YADHAaEM-----GNDVPE----EPVLFLKPPSALVGPGDPIPLPAGSGKLDYEGELAVVIGKRARNVSEEDALDHVAGY 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515639723 173 MLVNDVSLRGLI-----PAELAKGFgffqskPSSA-FSPVAVTPDELGEqwkgskVH-LPLISTYNDQPfgcpnagV--- 242
Cdd:COG0179   86 TVANDVTARDLQrerggQWTRGKSF------DTFCpLGPWIVTADEIPD------PQdLRIRLRVNGEV-------Rqdg 146

                        170       180       190
                 ....*....|....*....|....*....|..
gi 515639723 243 ---DMTFNFAELVVHAAKTRPLSAGAIIGSGT 271
Cdd:COG0179  147 ntsDMIFSVAELIAYLSQFMTLEPGDVILTGT 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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