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Conserved domains on  [gi|515650535|ref|WP_017083135|]
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methyl-accepting chemotaxis protein [Vibrio splendidus]

Protein Classification

methyl-accepting chemotaxis protein( domain architecture ID 11435591)

methyl-accepting chemotaxis protein (MCP) is a bacterial receptor that mediates chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behavior

CATH:  1.10.287.950
Gene Ontology:  GO:0006935
PubMed:  18165013|20738376
SCOP:  4003862

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
19-553 3.07e-78

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


:

Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 256.10  E-value: 3.07e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  19 LMAIGMMSVTYMKSTELTAQQVESTRSNMMAMKEKELKAYLQMAYSSISPFLDKGATLEEALPTLKTLEYGESGYIFGYD 98
Cdd:COG0840    1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  99 SKGVRVVVGQSNDGIGKNYYDLQDKQGNYLIRDLIKNSKLGEFTTYYFPKPGQSVALPKLSYSVFVPQWDLMLGTGFYTD 178
Cdd:COG0840   81 LLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 179 DIDAVIAEMKESSNIALQSSLTAIAIFCGLIALVVAVFAVAVNRTIMQPLEQFDRSISAFASGeaDLTARMEKFKAPEFT 258
Cdd:COG0840  161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEG--DLTVRIDVDSKDEIG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 259 KLSENFNAFVASLQTIIRSVSDVGQQVVAETSSMSSRAAQVDEIATGQREETEQVATAMTEMTTTAQEISSNASQAADSA 338
Cdd:COG0840  239 QLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 339 KLAEGNAKEAQQIVNAAANSVAGLASEVSEANTVVSRLEGDVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQGRGF 418
Cdd:COG0840  319 EEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGF 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 419 AVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMDSSQNKSAQTVEEANAAAAALAKIQESIDTIMDMNSLIATA 498
Cdd:COG0840  399 AVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAA 478

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 515650535 499 TEQQNIVGQEISQRIVVISDQSSQSASLANQNRAGSQNLNSRANELYHLVDRFTV 553
Cdd:COG0840  479 SEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
19-553 3.07e-78

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 256.10  E-value: 3.07e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  19 LMAIGMMSVTYMKSTELTAQQVESTRSNMMAMKEKELKAYLQMAYSSISPFLDKGATLEEALPTLKTLEYGESGYIFGYD 98
Cdd:COG0840    1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  99 SKGVRVVVGQSNDGIGKNYYDLQDKQGNYLIRDLIKNSKLGEFTTYYFPKPGQSVALPKLSYSVFVPQWDLMLGTGFYTD 178
Cdd:COG0840   81 LLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 179 DIDAVIAEMKESSNIALQSSLTAIAIFCGLIALVVAVFAVAVNRTIMQPLEQFDRSISAFASGeaDLTARMEKFKAPEFT 258
Cdd:COG0840  161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEG--DLTVRIDVDSKDEIG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 259 KLSENFNAFVASLQTIIRSVSDVGQQVVAETSSMSSRAAQVDEIATGQREETEQVATAMTEMTTTAQEISSNASQAADSA 338
Cdd:COG0840  239 QLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 339 KLAEGNAKEAQQIVNAAANSVAGLASEVSEANTVVSRLEGDVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQGRGF 418
Cdd:COG0840  319 EEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGF 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 419 AVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMDSSQNKSAQTVEEANAAAAALAKIQESIDTIMDMNSLIATA 498
Cdd:COG0840  399 AVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAA 478

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 515650535 499 TEQQNIVGQEISQRIVVISDQSSQSASLANQNRAGSQNLNSRANELYHLVDRFTV 553
Cdd:COG0840  479 SEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 293-552 2.40e-59

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 197.89  E-value: 2.40e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   293 SSRAAQVDEIATGQREETEQVATAMTEMTTTAQEISSNASQAADSAKLAEGNAKEAQQIVNAAANSVAGLASEVSEANTV 372
Cdd:smart00283   3 SEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   373 VSRLEGDVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLASRTQESTGDIHKMIQQLKAASDA 452
Cdd:smart00283  83 VEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETNE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   453 AVKAMDSSQNKSAQTVEEANAAAAALAKIQESIDTIMDMNSLIATATEQQNIVGQEISQRIVVISDQSSQSASLANQNRA 532
Cdd:smart00283 163 AVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISA 242

                          250       260
                   ....*....|....*....|
gi 515650535   533 GSQNLNSRANELYHLVDRFT 552
Cdd:smart00283 243 AAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 325-511 6.35e-48

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 165.49  E-value: 6.35e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 325 QEISSNASQAADSAKLAEGNAKEAQQIVNAAANSVAGLASEVSEANTVVSRLEGDVQNISSSLTVIQDIAEQTNLLALNA 404
Cdd:cd11386    8 EEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTNLLALNA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 405 AIEAARAGEQGRGFAVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMDSSQNKSAQTVEEANAAAAALAKIQES 484
Cdd:cd11386   88 AIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAFEEIVAS 167

                        170       180
                 ....*....|....*....|....*..
gi 515650535 485 IDTIMDMNSLIATATEQQNIVGQEISQ 511
Cdd:cd11386  168 VEEVADGIQEISAATQEQSASTQEIAA 194
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 335-518 7.38e-32

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 121.00  E-value: 7.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  335 ADSAKLAEGNAKEAQQivnaaansvaglasEVSEANTVVSRLEGDVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQ 414
Cdd:pfam00015   1 SDLAQLASEEAQDGGK--------------EVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  415 GRGFAVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMDSSQNKSAQTVEEANAAAAALAKIQESIDTIMDMNSL 494
Cdd:pfam00015  67 GRGFAVVADEVRKLAERSAQAAKEIEALIIEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQE 146

                         170       180
                  ....*....|....*....|....
gi 515650535  495 IATATEQQNIVGQEISQRIVVISD 518
Cdd:pfam00015 147 IAAASDEQSAGIDQVNQAVARMDQ 170
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
179-553 1.06e-30

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 125.95  E-value: 1.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 179 DIDAVIAEMKESSNIALQSSLTAIAIFCGLIALVVAVFAVAVNRTIMQPLEQFDRSISAFASGeaDLTARMEKFKAPEFT 258
Cdd:PRK09793 169 EINHVLEAASAQSQRNYQISALVFISMIIVAAIYISSALWWTRKMIVQPLAIIGSHFDSIAAG--NLARPIAVYGRNEIT 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 259 KLsenFNAFVASLQTIIRSVSDVGQQVVAETSSMSSRAAQVDEIATgqreETEQVATAMTEMTTTAQEISSNASQAADSA 338
Cdd:PRK09793 247 AI---FASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSS----RTEQQAASLAQTAASMEQLTATVGQNADNA 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 339 KLAEGNAKEAQQIVNAAANSVAGLASEVSEANTvvsrlegDVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQGRGF 418
Cdd:PRK09793 320 RQASELAKNAATTAQAGGVQVSTMTHTMQEIAT-------SSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGF 392

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 419 AVVADEVRKLASRTQESTGDIHKMIQQlkaaSDAAVKAMDSSQNKSAQTVEEanaaaaalakIQESIDTIMDMNSLIATA 498
Cdd:PRK09793 393 AVVAGEVRNLASRSAQAAKEIKGLIEE----SVNRVQQGSKLVNNAAATMTD----------IVSSVTRVNDIMGEIASA 458

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 515650535 499 TEQQNIVGQEISQRIVVISDQSSQSASLANQNRAGSQNLNSRANELYHLVDRFTV 553
Cdd:PRK09793 459 SEEQRRGIEQVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTL 513
 
Name Accession Description Interval E-value
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
19-553 3.07e-78

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 256.10  E-value: 3.07e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  19 LMAIGMMSVTYMKSTELTAQQVESTRSNMMAMKEKELKAYLQMAYSSISPFLDKGATLEEALPTLKTLEYGESGYIFGYD 98
Cdd:COG0840    1 LLILLLLLALLLALLLLALSLLALLAAALLILLALLLAALTALALLLLLSLLALLLLLLLLALALLLVLLALLLLLALVV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  99 SKGVRVVVGQSNDGIGKNYYDLQDKQGNYLIRDLIKNSKLGEFTTYYFPKPGQSVALPKLSYSVFVPQWDLMLGTGFYTD 178
Cdd:COG0840   81 LLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALALLALALLAAAAAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 179 DIDAVIAEMKESSNIALQSSLTAIAIFCGLIALVVAVFAVAVNRTIMQPLEQFDRSISAFASGeaDLTARMEKFKAPEFT 258
Cdd:COG0840  161 AALAALLEAAALALAAAALALALLAAALLALVALAIILALLLSRSITRPLRELLEVLERIAEG--DLTVRIDVDSKDEIG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 259 KLSENFNAFVASLQTIIRSVSDVGQQVVAETSSMSSRAAQVDEIATGQREETEQVATAMTEMTTTAQEISSNASQAADSA 338
Cdd:COG0840  239 QLADAFNRMIENLRELVGQVRESAEQVASASEELAASAEELAAGAEEQAASLEETAAAMEELSATVQEVAENAQQAAELA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 339 KLAEGNAKEAQQIVNAAANSVAGLASEVSEANTVVSRLEGDVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQGRGF 418
Cdd:COG0840  319 EEASELAEEGGEVVEEAVEGIEEIRESVEETAETIEELGESSQEIGEIVDVIDDIAEQTNLLALNAAIEAARAGEAGRGF 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 419 AVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMDSSQNKSAQTVEEANAAAAALAKIQESIDTIMDMNSLIATA 498
Cdd:COG0840  399 AVVADEVRKLAERSAEATKEIEELIEEIQSETEEAVEAMEEGSEEVEEGVELVEEAGEALEEIVEAVEEVSDLIQEIAAA 478

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 515650535 499 TEQQNIVGQEISQRIVVISDQSSQSASLANQNRAGSQNLNSRANELYHLVDRFTV 553
Cdd:COG0840  479 SEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQELVSRFKL 533
MA smart00283
Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo ...
 293-552 2.40e-59

Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Thought to undergo reversible methylation in response to attractants or repellants during bacterial chemotaxis.


Pssm-ID: 214599 [Multi-domain]  Cd Length: 262  Bit Score: 197.89  E-value: 2.40e-59
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   293 SSRAAQVDEIATGQREETEQVATAMTEMTTTAQEISSNASQAADSAKLAEGNAKEAQQIVNAAANSVAGLASEVSEANTV 372
Cdd:smart00283   3 SEAVEEIAAGAEEQAEELEELAERMEELSASIEEVAANADEIAATAQSAAEAAEEGREAVEDAITAMDQIREVVEEAVSA 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   373 VSRLEGDVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLASRTQESTGDIHKMIQQLKAASDA 452
Cdd:smart00283  83 VEELEESSDEIGEIVSVIDDIADQTNLLALNAAIEAARAGEAGRGFAVVADEVRKLAERSAESAKEIESLIKEIQEETNE 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   453 AVKAMDSSQNKSAQTVEEANAAAAALAKIQESIDTIMDMNSLIATATEQQNIVGQEISQRIVVISDQSSQSASLANQNRA 532
Cdd:smart00283 163 AVAAMEESSSEVEEGVELVEETGDALEEIVDSVEEIADLVQEIAAATDEQAAGSEEVNAAIDEIAQVTQETAAMSEEISA 242

                          250       260
                   ....*....|....*....|
gi 515650535   533 GSQNLNSRANELYHLVDRFT 552
Cdd:smart00283 243 AAEELSGLAEELDELVERFK 262
MCP_signal cd11386
Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis ...
 325-511 6.35e-48

Methyl-accepting chemotaxis protein (MCP), signaling domain; Methyl-accepting chemotaxis proteins (MCPs or chemotaxis receptors) are an integral part of the transmembrane protein complex that controls bacterial chemotaxis, together with the histidine kinase CheA, the receptor-coupling protein CheW, receptor-modification enzymes, and localized phosphatases. MCPs contain a four helix trans membrane region, an N-terminal periplasmic ligand binding domain, and a C-terminal HAMP domain followed by a cytoplasmic signaling domain. This C-terminal signaling domain dimerizes into a four-helix bundle and interacts with CheA through the adaptor protein CheW.


Pssm-ID: 206779 [Multi-domain]  Cd Length: 200  Bit Score: 165.49  E-value: 6.35e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 325 QEISSNASQAADSAKLAEGNAKEAQQIVNAAANSVAGLASEVSEANTVVSRLEGDVQNISSSLTVIQDIAEQTNLLALNA 404
Cdd:cd11386    8 EEVAASADQVAETSQQAAELAEKGREAAEDAINQMNQIDESVDEAVSAVEELEESSAEIGEIVEVIDDIAEQTNLLALNA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 405 AIEAARAGEQGRGFAVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMDSSQNKSAQTVEEANAAAAALAKIQES 484
Cdd:cd11386   88 AIEAARAGEAGRGFAVVADEVRKLAEESAEAAKEIEELIEEIQEQTEEAVEAMEETSEEVEEGVELVEETGRAFEEIVAS 167

                        170       180
                 ....*....|....*....|....*..
gi 515650535 485 IDTIMDMNSLIATATEQQNIVGQEISQ 511
Cdd:cd11386  168 VEEVADGIQEISAATQEQSASTQEIAA 194
COG4564 COG4564
Signal transduction histidine kinase [Signal transduction mechanisms];
17-527 1.73e-38

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 443621 [Multi-domain]  Cd Length: 510  Bit Score: 147.87  E-value: 1.73e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  17 LLLMAIGMMSVTYMksteltaqQVESTRSNMMAMKEKELKAYLQMAYSSISPFLDKGATLEE-----ALPTLKTLEYGES 91
Cdd:COG4564    4 LLLLLLALLALAAL--------SLETLRQALLEERKAELRALVELAVSIIAALYAAGELSEEeakeqALAALRALRFGGD 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  92 GYIFGYDSKGVRVVVGQSNDGIGKNYYDLQDKQGNYLIRDLIKNSKL--GEFTTYYFPKPGQSVALPKLSYSVFVPQWDL 169
Cdd:COG4564   76 GYFFVYDYDGTMLAHPINPELVGKNLLDLKDANGKYLIRELIEAAKKkgGGFVEYLWPKPGSGKPEPKLSYVKKFPPWDW 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 170 MLGTGFYTDDIDAVIAEMKESSNIALQSSLTAIAIFcglIALVVAVFAVAVNRTIMQPLEQFDRSISAFASGEADLTARM 249
Cdd:COG4564  156 VIGTGVYLDDIEAAFAAAALELLLLLALLLALALAL---LLLVLAALAGLLLASALEGELNLAGALAALLLAAAAELLAA 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 250 EKFKAPEFTKLSENFNAFVASLQTIIRSVSDVGQQVVAETSSMSSRAAQVDEIATGQREETEQVATAMTEMTTTAQEISS 329
Cdd:COG4564  233 LLLIGAAAGALLALAEAVAAVLAEALAAAAAAAAASAAASSAALAAAAAEAEAALAASEASAAAALAAAAAAAAAAAAAA 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 330 NASQAADSAKLAEGNAKEAQQIVNAAANSVAGLASEVSEANTVVSRLEGDVQNISSSLTVIQDIAEQTNLLALNAAIEAA 409
Cdd:COG4564  313 AAAEAAAAAAAAAAAAAAAAASVADVAALAAAAAAAAAIAALAAAAAAAAAAAAAAAAIAAAAAAAAAAAAAAAAAAAEA 392

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 410 RAGEQGRGFAVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMDSSQNKSAQTVEEANAAAAALAKIQESIDTIM 489
Cdd:COG4564  393 AAAAAAAATAAAALEAVAAAAAAAAAAAAAEAAAAEVEAAAAITAIILEAAAAAAAAIEAEEAAAVAAAAALAAEAAAAA 472

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 515650535 490 DMNSLIATATEQQNIVGQEISQRIVVISDQSSQSASLA 527
Cdd:COG4564  473 AAAAEAAAAAAAAEAASAVVSAAAAAAAAGAAAALALA 510
MCPsignal pfam00015
Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to ...
 335-518 7.38e-32

Methyl-accepting chemotaxis protein (MCP) signalling domain; This domain is thought to transduce the signal to CheA since it is highly conserved in very diverse MCPs.


Pssm-ID: 333767 [Multi-domain]  Cd Length: 172  Bit Score: 121.00  E-value: 7.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  335 ADSAKLAEGNAKEAQQivnaaansvaglasEVSEANTVVSRLEGDVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQ 414
Cdd:pfam00015   1 SDLAQLASEEAQDGGK--------------EVANVVGQMEQIAQSSKKISDIISVIDEIAFQTNLLALNAAIEAARAGEQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535  415 GRGFAVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMDSSQNKSAQTVEEANAAAAALAKIQESIDTIMDMNSL 494
Cdd:pfam00015  67 GRGFAVVADEVRKLAERSAQAAKEIEALIIEIQKQTNDSTASIESTRQRVEVGSTIVESTGEALKEIVDAVAEIADIVQE 146

                         170       180
                  ....*....|....*....|....
gi 515650535  495 IATATEQQNIVGQEISQRIVVISD 518
Cdd:pfam00015 147 IAAASDEQSAGIDQVNQAVARMDQ 170
PRK09793 PRK09793
methyl-accepting chemotaxis protein IV;
179-553 1.06e-30

methyl-accepting chemotaxis protein IV;


Pssm-ID: 182079 [Multi-domain]  Cd Length: 533  Bit Score: 125.95  E-value: 1.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 179 DIDAVIAEMKESSNIALQSSLTAIAIFCGLIALVVAVFAVAVNRTIMQPLEQFDRSISAFASGeaDLTARMEKFKAPEFT 258
Cdd:PRK09793 169 EINHVLEAASAQSQRNYQISALVFISMIIVAAIYISSALWWTRKMIVQPLAIIGSHFDSIAAG--NLARPIAVYGRNEIT 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 259 KLsenFNAFVASLQTIIRSVSDVGQQVVAETSSMSSRAAQVDEIATgqreETEQVATAMTEMTTTAQEISSNASQAADSA 338
Cdd:PRK09793 247 AI---FASLKTMQQALRGTVSDVRKGSQEMHIGIAEIVAGNNDLSS----RTEQQAASLAQTAASMEQLTATVGQNADNA 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 339 KLAEGNAKEAQQIVNAAANSVAGLASEVSEANTvvsrlegDVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQGRGF 418
Cdd:PRK09793 320 RQASELAKNAATTAQAGGVQVSTMTHTMQEIAT-------SSQKIGDIISVIDGIAFQTNILALNAAVEAARAGEQGRGF 392

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 419 AVVADEVRKLASRTQESTGDIHKMIQQlkaaSDAAVKAMDSSQNKSAQTVEEanaaaaalakIQESIDTIMDMNSLIATA 498
Cdd:PRK09793 393 AVVAGEVRNLASRSAQAAKEIKGLIEE----SVNRVQQGSKLVNNAAATMTD----------IVSSVTRVNDIMGEIASA 458

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 515650535 499 TEQQNIVGQEISQRIVVISDQSSQSASLANQNRAGSQNLNSRANELYHLVDRFTV 553
Cdd:PRK09793 459 SEEQRRGIEQVAQAVSQMDQVTQQNASLVEEAAVATEQLANQADHLSSRVAVFTL 513
sCache_2 pfam17200
Single Cache domain 2; This entry represents the single Cache domain 2 (sCache_2), which ...
 47-188 1.10e-26

Single Cache domain 2; This entry represents the single Cache domain 2 (sCache_2), which contains the long N-terminal helix domain. This domain recognizes pyruvate, acetate, propionate, glycolate, L-lactate, acetoacetate, urea and hydroxyurea, acetamide, formamide, L-malate and citromalate, malonate, methyl and bromosuccinate and citraconic acid (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 435780 [Multi-domain]  Cd Length: 153  Bit Score: 105.90  E-value: 1.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   47 MMAMKEKELKAYLQMAYSSISP----FLDKGATLEEA----LPTLKTLEYGE-SGYIFGYDSKGVRVVVGQSNDGIGKNY 117
Cdd:pfam17200   1 LIDQGKAQLKNLVNGAISLIEAvyaqVESGKITLEEAqelaKELILGPRYGDgDGYFWVYDEDGNMLVHPFNPQLEGQNR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515650535  118 YDLQDKQGNYLIRDLIKNSKL--GEFTTYYFPKPGQSVALPKLSYSVFVPQWDLMLGTGFYTDDIDAVIAEMK 188
Cdd:pfam17200  81 SNLKDANGKYFIRELIATAKKagGGFVTYLWKNPGEKAVEPKLAYVKYFPPWDWVIGTGSYMDDINAAAEKIL 153
PRK15041 PRK15041
methyl-accepting chemotaxis protein;
223-553 1.69e-24

methyl-accepting chemotaxis protein;


Pssm-ID: 185001 [Multi-domain]  Cd Length: 554  Bit Score: 107.35  E-value: 1.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 223 TIMQPLEQFDRSISAFASGeaDLTARMEKFKAPEFTKLSENFNAFVASLqtiIRSVSDVGQQVVAETSSMSsraaqvdEI 302
Cdd:PRK15041 217 SLVAPMNRLIDSIRHIAGG--DLVKPIEVDGSNEMGQLAESLRHMQGEL---MRTVGDVRNGANAIYSGAS-------EI 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 303 ATGQRE---ETEQVATAMTEMTTTAQEISSNASQAADsaklaegNAKEAQQIVNAAANSVAGLASEVSEANTVVSRLEGD 379
Cdd:PRK15041 285 ATGNNDlssRTEQQAASLEETAASMEQLTATVKQNAE-------NARQASHLALSASETAQRGGKVVDNVVQTMRDISTS 357

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 380 VQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMDS 459
Cdd:PRK15041 358 SQKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLAQRSAQAAREIKSLIEDSVGKVDVGSTLVES 437

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 460 sqnkSAQTVEEanaaaaalakIQESIDTIMDMNSLIATATEQQNIVGQEISQRIVVISDQSSQSASLANQNRAGSQNLNS 539
Cdd:PRK15041 438 ----AGETMAE----------IVSAVTRVTDIMGEIASASDEQSRGIDQVGLAVAEMDRVTQQNAALVEESAAAAAALEE 503

                        330
                 ....*....|....
gi 515650535 540 RANELYHLVDRFTV 553
Cdd:PRK15041 504 QASRLTEAVAVFRI 517
dCache_2 pfam08269
Cache domain; Double Cache domain 2 (dCache_2) may be a result of single Cache domain 2 ...
 77-181 1.72e-24

Cache domain; Double Cache domain 2 (dCache_2) may be a result of single Cache domain 2 (sCache_2) duplication.


Pssm-ID: 462414 [Multi-domain]  Cd Length: 298  Bit Score: 103.61  E-value: 1.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   77 EEALPTLKTLEYGESGYIFGYDSKGVRVVVGQSNDGIGKNYYDLQDKQGNYLIRDLIKNSKLGE--FTTYYFPKPGQSVA 154
Cdd:pfam08269 192 QELLKTLASIRYGNNGYIFIYDTDGNMILHPLKPELNGKDLTENKDDKGQELFQELLEAAKKKGegFVTYKWPKPGGDKP 271

                          90       100
                  ....*....|....*....|....*..
gi 515650535  155 LPKLSYSVFVPQWDLMLGTGFYTDDID 181
Cdd:pfam08269 272 RPKISYVRYFPPWDWIIGTGVYLDEIE 298
PRK15048 PRK15048
methyl-accepting chemotaxis protein II; Provisional
 222-551 8.60e-24

methyl-accepting chemotaxis protein II; Provisional


Pssm-ID: 185008 [Multi-domain]  Cd Length: 553  Bit Score: 105.09  E-value: 8.60e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 222 RTIMQPLEQFDRSISAFASGeaDLTARMEKFKAPEFTKLSENFNAFVASLQTIIRSVSDVGQQVVAETSsmssraaqvdE 301
Cdd:PRK15048 214 RMLLTPLAKIIAHIREIAGG--NLANTLTIDGRSEMGDLAQSVSHMQRSLTDTVTHVREGSDAIYAGTR----------E 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 302 IATGQRE---ETEQVATAMTEMTTTAQEISSNASQAADSAKLAEGNAKEAQQIVNAAANSVAGLASEVSEantvvsrLEG 378
Cdd:PRK15048 282 IAAGNTDlssRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASDTAQHGGKVVDGVVKTMHE-------IAD 354

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 379 DVQNISSSLTVIQDIAEQTNLLALNAAIEAARAGEQGRGFAVVADEVRKLASRTQESTGDIHKMIQQLKAASDAAVKAMD 458
Cdd:PRK15048 355 SSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKEIKALIEDSVSRVDTGSVLVE 434

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535 459 SsqnkSAQTVEEanaaaaalakIQESIDTIMDMNSLIATATEQQNivgQEISQRIVVISDQ---SSQSASLANQNRAGSQ 535
Cdd:PRK15048 435 S----AGETMNN----------IVNAVTRVTDIMGEIASASDEQS---RGIDQVALAVSEMdrvTQQNASLVQESAAAAA 497

                        330
                 ....*....|....*.
gi 515650535 536 NLNSRANELYHLVDRF 551
Cdd:PRK15048 498 ALEEQASRLTQAVSAF 513
dCache_2 pfam08269
Cache domain; Double Cache domain 2 (dCache_2) may be a result of single Cache domain 2 ...
 38-184 6.48e-20

Cache domain; Double Cache domain 2 (dCache_2) may be a result of single Cache domain 2 (sCache_2) duplication.


Pssm-ID: 462414 [Multi-domain]  Cd Length: 298  Bit Score: 90.51  E-value: 6.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   38 QQVESTRSNMMAMKEKELKAYLQMAYSSISPFLDK-GATL--EEALPTLKTL-----EYGESGYIFGYDSKGVRVVVGQS 109
Cdd:pfam08269  33 DYINYYKNSLEESLKESLKSRVNEAYSIAESIYEKyKNKLseEEIKKLIKEAlrsirFNDGTGYYFIIDKKGTVILHPDN 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515650535  110 NDGIGKNYYDLQDKQGNYLIRDLIK-NSKLGE-FTTYYFPKPGQS-VALPKLSYSVFVPQWDLMLGTGFYTDDIDAVI 184
Cdd:pfam08269 113 PSLEGKNLLDLKDKDGRYIIREMIKlAKKKGEgFVDYLWPKPNGSdKPYKKISYVKYFEPLDWIIGTGEYLDDIEEEI 190
Cache_2 smart01049
Cache is an extracellular domain that is predicted to have a role in small-molecule ...
 47-129 2.65e-15

Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Members include the animal dihydropyridine-sensitive voltage-gated Ca2+ channel; alpha-2delta subunit, and various bacterial chemotaxis receptors. The name Cache comes from CAlcium channels and CHEmotaxis receptors. This domain consists of an N-terminal part with three predicted strands and an alpha-helix, and a C-terminal part with a strand dyad followed by a relatively unstructured region. The N-terminal portion of the (unpermuted) Cache domain contains three predicted strands that could form a sheet analogous to that present in the core of the PAS domain structure. Cache domains are particularly widespread in bacteria, with Vibrio cholerae. The animal calcium channel alpha-2delta subunits might have acquired a part of their extracellular domains from a bacterial source. The Cache domain appears to have arisen from the GAF-PAS fold despite their divergent functions.


Pssm-ID: 214995 [Multi-domain]  Cd Length: 91  Bit Score: 71.13  E-value: 2.65e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535    47 MMAMKEKELKAYLQMAYSSISPF--------LDKGATLEEALPTLKTLEYGESGYIFGYDSKGVRVVVGQSNDGIGKNYY 118
Cdd:smart01049   1 LLEERKAELKNLVEIAVSIVEAYyaqaaagkLTEEEAQAQAKAALRALRYGGDGYFFVYDSDGVMLMHPAKPELEGKNLS 80

                           90
                   ....*....|.
gi 515650535   119 DLQDKQGNYLI 129
Cdd:smart01049  81 DLKDPNGKYLF 91
Cache_3-Cache_2 pfam17201
Cache 3/Cache 2 fusion domain; The Cache_3-Cache_2 domain likely originated as a fusion of ...
 74-184 8.44e-06

Cache 3/Cache 2 fusion domain; The Cache_3-Cache_2 domain likely originated as a fusion of sCache_3 and sCache_2 domains.


Pssm-ID: 465378 [Multi-domain]  Cd Length: 298  Bit Score: 47.73  E-value: 8.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515650535   74 ATLEEALPTLKTLEYGESGYIFGYDSKG---VRVVVgqSNDGIGKNYYDLQDKQGNYLIRDLIKnSKLGEFTtYYFPKPG 150
Cdd:pfam17201 185 EALASLRKAIKKVKIGKTGYLYVLDGKGdqkGKFIV--HPTLEGKNILDAKDADGEPFVKKLLQ-KKVGSLE-YPWKADA 260

                          90       100       110
                  ....*....|....*....|....*....|....
gi 515650535  151 QSVAlpKLSYSVFVPQWDLMLGTGFYTDDIDAVI 184
Cdd:pfam17201 261 AGRD--KLAAFTYFEPWDWVIVASVYEDEFLAAT 292
HAMP smart00304
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
222-276 6.79e-05

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;


Pssm-ID: 197640 [Multi-domain]  Cd Length: 53  Bit Score: 40.69  E-value: 6.79e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 515650535   222 RTIMQPLEQFDRSISAFASGeaDLTARMEKFKAPEFTKLSENFNAFVASLQTIIR 276
Cdd:smart00304   1 RRLLRPLRRLAEAAQRIADG--DLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
HAMP pfam00672
HAMP domain;
222-273 7.99e-04

HAMP domain;


Pssm-ID: 459898 [Multi-domain]  Cd Length: 53  Bit Score: 37.60  E-value: 7.99e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 515650535  222 RTIMQPLEQFDRSISAFASGeaDLTARMEKFKAPEFTKLSENFNAFVASLQT 273
Cdd:pfam00672   4 RRILRPLRRLAEAARRIASG--DLDVRLPVSGRDEIGELARAFNQMAERLRE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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