|
Name |
Accession |
Description |
Interval |
E-value |
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
2-456 |
0e+00 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 803.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 2 LKFLDQVRKPTLDLPVETRRKMWFKPFLQSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIG 81
Cdd:PRK09556 1 LAFLNQVRKPTLDLPLEVQRKMWFKPFMQSYLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 82 KTVVSYYADGKNTKQFLPFMLVLSGIAMLGFSFSMGGGSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYL 161
Cdd:PRK09556 81 KTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 162 GLWNMSHNVGGAGAAGVALFGANYLFDGNVVGMFVFPSIIAIVVGFIGMRFGNDSPEAYGLGTVEELFDEEISEEDTIAE 241
Cdd:PRK09556 161 GFWNISHNLGGAGAGGVALWGANYFFDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 242 ENQMTKKEIFVEYILKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDL 321
Cdd:PRK09556 241 STDMTKWQIFVEYVLKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 322 ANGRRALVACVSLGLIIVSLEFYQNATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGDS 401
Cdd:PRK09556 321 ANGRRALVACIALALIIFTLGVYQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLFGDS 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515661629 402 FAKLGLGMIAD----GTPIFG--LTGWKGTFAALDTSAAICIVLLLFVAVAEEKKIRHAKK 456
Cdd:PRK09556 401 FAKVGLGMIADptknGTPIFGytLTGWAGTFAALDIAAIGCICLMAIVAVMEERKIRREKK 461
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
28-444 |
6.22e-160 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 458.63 E-value: 6.22e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 28 FLQSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGI 107
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 108 AMLGFSFSMGGGSaSLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLF 187
Cdd:cd17345 81 INILIGFVPSATS-SVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 188 DGNVVGMFVFPSIIAIVVGFIGMRFGNDSPEAYGLGTVEELFDEEISEEDTIAEENQMTKKEIFVEYILKNKVIWLLCFA 267
Cdd:cd17345 160 DGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 268 NIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSD-LANGRRALVACVSLGLIIVSLEFYQN 346
Cdd:cd17345 240 NVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDkLFKGRRAPTGIIFMILVIVALIVYWL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 347 ATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGDSFAKLGLGMIADgtpifgLTGWKGTF 426
Cdd:cd17345 320 APNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLATALIGIIVD------HFGWNGGF 393
|
410
....*....|....*...
gi 515661629 427 AALDTSAAICIVLLLFVA 444
Cdd:cd17345 394 IVLLASCILAIIFLALVA 411
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-426 |
2.03e-129 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 379.80 E-value: 2.03e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 36 FIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGFSFS 115
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 116 MgggsaSLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLFDGNVVgmF 195
Cdd:TIGR00881 81 T-----SLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWV--F 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 196 VFPSIIAIVVGFIGMRFGNDSPEAYGLGTVEELFDEEiSEEDTIAEENQMTKKEIFVEYILKNKVIWLLCFANIFLYIVR 275
Cdd:TIGR00881 154 IVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE-PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 276 IGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSD-LANGRRALVACVSLGLIIVSLEFYQ--NATSEFM 352
Cdd:TIGR00881 233 TGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVYWlnPAANPLM 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515661629 353 YLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGdSFAKLGLGMIADGtpifglTGWKGTF 426
Cdd:TIGR00881 313 DLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGG-ILAGLPLGYLADG------FGWAGAF 379
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
29-441 |
2.58e-66 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 219.20 E-value: 2.58e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 29 LQSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIA 108
Cdd:PRK11663 22 RHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGII 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 109 MLGFSFSmgggsASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGAnyLFD 188
Cdd:PRK11663 102 NILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIA--LHY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 189 GNVVGMfVFPSIIAIVVGFIGMRFGNDSPEAYGLGTVEELFDEEISeedtIAEENQ---MTKKEIFVEYILKNKVIWLLC 265
Cdd:PRK11663 175 GWRYGM-MIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALE----LAQQQEgagLSRKEILTKYVLLNPYIWLLS 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 266 FANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSD-LANGRRA---LVACVSLGLIIVSL 341
Cdd:PRK11663 250 FSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDkLFNGNRGpmnLIFAAGILLSVGSL 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 342 eFYQNATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLiGDSFAKLGLGMIADgtpifgLTG 421
Cdd:PRK11663 330 -WLMPFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GAALSGYPLAKVLE------IWH 401
|
410 420
....*....|....*....|
gi 515661629 422 WKGTFAALDTSAAICIVLLL 441
Cdd:PRK11663 402 WTGFFVVISIAAGISALLLL 421
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
7-462 |
2.72e-62 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 209.18 E-value: 2.72e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 7 QVRKPTLDLPVETRRKMWfkpflQSYLVVFIGYLTMYLIRKNFNVAQNDMISTyGLSMTDLGLIGLGFSITYGIGKTVVS 86
Cdd:PRK11273 11 KARLPAAEIDPTYRRLRW-----QIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 87 YYADGKNTKQFLPFMLVLSGIAMLGFSFsMGGGSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNM 166
Cdd:PRK11273 85 SVSDRSNPRVFLPAGLILAAAVMLFMGF-VPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNC 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 167 SHNVGGAGAAGVALFGANYLFDGNVVgmFVFPSIIAIVVGFIGMRFGNDSPEAYGLGTVEElFDEEISEEDTIAEENQMT 246
Cdd:PRK11273 164 AHNVGGGLPPLLFLLGMAWFNDWHAA--LYMPAFAAILVALFAFAMMRDTPQSCGLPPIEE-YKNDYPDDYNEKHEQELT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 247 KKEIFVEYILKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSD-LANGR 325
Cdd:PRK11273 241 AKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDkVFRGN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 326 RALVACVSLGLI-IVSLEFYQN-ATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGDSFA 403
Cdd:PRK11273 321 RGATGVFFMTLVtIATIVYWLNpAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAA 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 515661629 404 KLGLGMIADgtpifgLTGWKGTFAALDTSAAICIVLLLFVAVAEEKkiRHAKKMHLAAQ 462
Cdd:PRK11273 401 SAIVGYTVD------FFGWDGGFMVMIGGSILAVILLIVVMIGEKR--HHEELLQKRNG 451
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-443 |
1.28e-52 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 180.93 E-value: 1.28e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 30 QSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAM 109
Cdd:cd17312 3 RIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALAN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 110 LGFSFsmgggSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLFDG 189
Cdd:cd17312 83 IFMGF-----STSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 190 NVvgmFVFPSIIAIVVGFIGMRFGNDSPeayglgtveelfdeeiseedtiaeenqmtkkeifveyilknKVIWLLCFANI 269
Cdd:cd17312 158 AA---FLVPGIVGLVVAIILFFFLRDSP-----------------------------------------PYVWVLSLAYA 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 270 FLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLA-NGRRALVACVSLGLIIVSLE-FYQNA 347
Cdd:cd17312 194 FVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfGGRRAPIAVIYMLLMTLSLAlFWFFP 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 348 TSEFMYLASLFVLGFLVFGPQLLIG-VAAVGFVPKKAISVADGVKGTFAYlIGDSFAKLGLGMIADGtpifglTGWKGTF 426
Cdd:cd17312 274 HNKLLSIVLLFLIGFFVGGPINLIGgAAAQDIGRKEAAGTATGFVGLFGY-LGASLAGLPLGYIIDH------YGWSTVF 346
|
410
....*....|....*..
gi 515661629 427 AALdTSAAICIVLLLFV 443
Cdd:cd17312 347 YFL-ISAALLSVLLLLS 362
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
35-441 |
9.43e-52 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 178.75 E-value: 9.43e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 35 VFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGFSF 114
Cdd:cd17488 8 MFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 115 SmgggsASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGAnyLFDGNVVGM 194
Cdd:cd17488 88 S-----SSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAA--LTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 195 FVfPSIIAIVVGfigmrfgndspeayglgtveelfdeeiseedtiaeenqmtkkeIFVEYILKNK--VIWLLCFANIFLY 272
Cdd:cd17488 161 YV-PGIIAILMG-------------------------------------------IVLCWRLRDRppYIWLLAFCYVLVY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 273 IVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSD-LANGRRALVACV-SLGLIIVSLEFYQNATSE 350
Cdd:cd17488 197 VVRTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDkLFKGNRGPMNLIfALGLLVSVGALWLVPVHS 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 351 FMYLASLF-VLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLiGDSFAKLGLGMIADgtpifgLTGWKGTFAAL 429
Cdd:cd17488 277 YWLLATCFfTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYL-GAALAGYPLAKVIE------SWGWSGFFIVI 349
|
410
....*....|..
gi 515661629 430 DTSAAICIVLLL 441
Cdd:cd17488 350 SIAAAISGLLLL 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
33-449 |
7.13e-43 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 155.03 E-value: 7.13e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 33 LVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGF 112
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 113 SFsmgggSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLfdgNVV 192
Cdd:COG2271 93 GF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF---GWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 193 GMFVFPSIIAIVVGFIGmrfgndspeayglgtveelfdeeiseedtiaeenqmtkkeifveyilknkvIWLLCFANIFLY 272
Cdd:COG2271 165 AAFLILGLPGLLLALLR---------------------------------------------------FWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 273 IVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRALVACVSLGLIIVSLEFYQNATSEFM 352
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 353 YLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYlIGDSFAKLGLGMIADgtpifgLTGWKGTFAALDTS 432
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF-LGGALGPLLVGYLLD------ATGYQAAFLLLAAL 346
|
410
....*....|....*..
gi 515661629 433 AAICIVLLLFVAVAEEK 449
Cdd:COG2271 347 ALLAALLALLLLRETRK 363
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
29-442 |
3.68e-29 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 118.21 E-value: 3.68e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 29 LQSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIA 108
Cdd:cd17343 2 LTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 109 MLGFSfsmggGSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLFD 188
Cdd:cd17343 82 TVAFS-----GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 189 GNVvgmFVFPSIIAIVVGFIGMRFGNDSPEAYGLGTVEElfdEEISEEDTIAEENQMTKKEIfveyiLKNKVIWLLCFAN 268
Cdd:cd17343 157 RST---LSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE---EESKGKKKKSPRGESTLKEL-----LLSPFLWLLSLGY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 269 IFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRALVACVS-------LGLIIVSL 341
Cdd:cd17343 226 LVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGNprmplalVFMAGLTV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 342 EFY------QNATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYlIGDSFAKLGLGMIADgtp 415
Cdd:cd17343 306 SLHlfrvhiTSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAAN-VGGVLAGLPFSYIAK--- 381
|
410 420
....*....|....*....|....*..
gi 515661629 416 ifgLTGWKGTFAALDTSAAICIVLLLF 442
Cdd:cd17343 382 ---HYDWRTAFLLLEILCAITVVILFL 405
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
35-441 |
6.55e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 88.25 E-value: 6.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 35 VFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGFSF 114
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 115 SmgggsASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGAnYLFDGNVVGM 194
Cdd:cd06174 81 A-----PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA-SSLGFGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 195 FVFPSIIAIVVGFIGMRFGNDSPEAyglgtveelfdeeiSEEDTIAEENQMTKKEIFVeyILKNKVIWLLCFANIFLYIV 274
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPES--------------ARAKNEEASSKSVLKLLKR--VLKNPGLWLLLLAIFLVNLA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 275 RIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRALVAcVSLGLIIVSLEFYQNATSEFMYL 354
Cdd:cd06174 219 YYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL-IGLLLMALGLALLLLAPSLLLLL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 355 ASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLiGDSFAKLGLGMIADGTpifglTGWKGTFAALDTSAA 434
Cdd:cd06174 298 LLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFL-GGAIGPLLAGFLLAAT-----FGLTGAFLVLAVLLL 371
|
....*..
gi 515661629 435 ICIVLLL 441
Cdd:cd06174 372 LAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
33-400 |
2.28e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.18 E-value: 2.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 33 LVVFIGYLTMYLIrknfNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGF 112
Cdd:COG2814 17 LGAFLSGLGIGIV----LPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 113 SFSMgggsaSLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLfdgNVV 192
Cdd:COG2814 93 ALAP-----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF---GWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 193 GMFVFPSIIAIVVGFIGMRFGNDSPEAYGLGTVEELFDeeiseedtiaeenqmtkkeifveyILKNKVIWLLCFANIFLY 272
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------------------------LLRRPRLLLLLLLAFLLG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 273 IVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRALVacVSLGLIIVSLEFYQNATSEFM 352
Cdd:COG2814 221 FGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL--IGLLLLALGLLLLALAGSLWL 298
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 515661629 353 YLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGD 400
Cdd:COG2814 299 LLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
35-399 |
4.39e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 85.16 E-value: 4.39e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 35 VFIGYLTMYLIRKNFNVA-QNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGFS 113
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 114 FSmgggsASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNvggagaagvalfganylfdgnvVG 193
Cdd:pfam07690 81 FA-----SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFG----------------------LG 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 194 MFVFPSIIAIVVGFIGMR--FGNDSPEAYGLGTVEELFDEEISEEDTIAEENQMTKKEIFVEYILKNKVIWLLcFANIFL 271
Cdd:pfam07690 134 AALGPLLGGLLASLFGWRaaFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLL-LALLLF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 272 YIVRIGIDQWSTVYAyQELGLSKETAISGFTLFEVGALVGTLMWGYLSD-LANGRRALVACVSLGLIIVSLEFYQNATSE 350
Cdd:pfam07690 213 GFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSS 291
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 515661629 351 FMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIG 399
Cdd:pfam07690 292 LWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGG 340
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
33-443 |
2.22e-17 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 83.78 E-value: 2.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 33 LVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGF 112
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 113 SFSmgggsASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLfdgNVV 192
Cdd:COG2223 88 ALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF---GWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 193 GMFVFPSIIAIVVGFIGMRFGNDSPEayglgtveelfDEEISEEDTIAEENQMtkkeifveyiLKNKVIWLLCFANIFLY 272
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPA-----------GAAAAAKASLRDQLEA----------LRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 273 IVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRALVacVSLGLIIVSLEFYQNATSEFM 352
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLL--IVFALMALGLLLLALALGSLW 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 353 YLASLFVLGFLVFGPQLLIGVAAVG-FVPKKAISVADGVKGTfAYLIGDSFAKLGLGMIADGTPIFGLTGWkgTFAALdt 431
Cdd:COG2223 297 LFLVLFLLLGLALGGGNGAVFALVPdIFPTKNAGAVYGLVGA-AGGLGGFLGPLLFGALLDATGSYTAAFL--VFAVL-- 371
|
410
....*....|..
gi 515661629 432 sAAICIVLLLFV 443
Cdd:COG2223 372 -ALVALVLTLLL 382
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
67-447 |
3.46e-16 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 80.05 E-value: 3.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 67 LGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGI--AMLGFSFSMGGGSASLFMMVAfyALSGFFQSTGGPSS 144
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLftALFGLGYYWNIHSLWYFVVVQ--ILAGLFQSTGWPSV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 145 YSTITKWTPRNKRGSYLGLWNmSHNVGgagaagvalfganylfdGNVVGM--------------FVFPSIIAIVVGFIGM 210
Cdd:cd17344 142 VACVGNWFGKGKRGLIMGIWN-SHTSV-----------------GNILGSliagifvssawglsFIVPGIIIAAMGVLVF 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 211 RFGNDSPEayglGTVEelfdeeiseedtiaeenqmtkkeiFVEYILKNKVIwllcfANIFLYivrigidqWSTVYAYQEL 290
Cdd:cd17344 204 LFLVEHPP----GVIE------------------------FSLCLFFAKLV-----SYTFLY--------WLPLYISNTA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 291 GLSKETAISGFTLFEVGALVGTLMWGYLSDLANGrRALVACVSLGLIIVSLEFYQ--NATSEFMYLASLFVLGFLVFGPQ 368
Cdd:cd17344 243 ILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGG-RATTCAAMLILAAPMLFIYNyfGQVSMTTNIVLLIVCGLLVNGPY 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 369 LLIGVAAvgfvpkkaisVADgvKGTFAYLIGDSFAKLGLGMIADGTPIFGL------------TGWKGTFAALDTSAAIC 436
Cdd:cd17344 322 ALITTAV----------SAD--LGTHKSLKGNARALATVTAIIDGTGSIGAalgpllaglissRGWNNVFYMLIAADVCA 389
|
410
....*....|.
gi 515661629 437 IVLLLFVAVAE 447
Cdd:cd17344 390 GLLLTRLVYKE 400
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
33-440 |
7.87e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 69.52 E-value: 7.87e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 33 LVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLgf 112
Cdd:cd17319 6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA-- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 113 sfsMGGGSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVggagaagvalfganylfdGNVV 192
Cdd:cd17319 84 ---LTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPL------------------GAAI 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 193 GMFVFPSIIA--------IVVGFIGMRFGndspeayglgtveelfdeeiseedtiaeenqmtkkeIFVEYILKNkvIWLL 264
Cdd:cd17319 143 GPPLSGWLLLlfgwrwafIIEGLLGLLLA------------------------------------VLWWFYLRQ--VWGL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 265 CFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSD-LANGRRALVACVSLGLIIVSLEF 343
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 344 YQNATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGdSFAKLGLGMIAD--GTPIFGLTg 421
Cdd:cd17319 265 AYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG-FVAPLLIGYLVDatGSYTAAFL- 342
|
410
....*....|....*....
gi 515661629 422 wkgTFAALDTSAAICIVLL 440
Cdd:cd17319 343 ---FLAAVALLAALLVLLL 358
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-444 |
1.20e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 66.04 E-value: 1.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 56 MISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMlgfsfSMGGGSASLFMMVAFYALSGF 135
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGL-----SLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 136 FQSTGGPSSYSTITKwTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLFDgnvVGMFVFPSIIAIVVGFIGMRFGND 215
Cdd:cd17478 97 GSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG---LGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 216 SPEAYglgtveelfdeeiseedtiaeENQMTKKEIFVEYILKNKVIWLLCFANIFLYIVRIGIDQWSTVYaYQELGLSKE 295
Cdd:cd17478 173 KKPEA---------------------KKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFY-LVQRGYSLV 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 296 TAISGFTLFEVGALVGTLMWGYLSDlANGRRALVACVSLGLIIVSLEFYQnaTSEFMYLASLFVLGFLVFGPQLLIGVAA 375
Cdd:cd17478 231 FAGLLLSLFLFAGAIGTLIGGPLSD-RFGRRRVIIASLLLAAPFLLLFLL--TPGIWSYILLVLAGFLLFASFPVTVVLA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515661629 376 VGFVPKKaISVADGVKGTFAYLIGdSFAKLGLGMIADgtpIFGLTgwkgtfAALDTSAAICIVLLLFVA 444
Cdd:cd17478 308 QELLPGN-VGLASGLMMGLSFGLG-GIGAPVLGALAD---AFGLE------SVLLILALLPLLGALLAF 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-442 |
1.73e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.13 E-value: 1.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 32 YLVVFIGYLTMYLIRKNFNVaqndMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLG 111
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPL----YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 112 FSFSmgggsASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGaagvalfganylfdGNV 191
Cdd:cd17325 78 FAFA-----TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLI--------------GPL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 192 VGMFVF-------PSIIAIVVGFIGMrfgndspeAYGLGTVEElfdeeiSEEDTIAEENQMTKKEIFVEYILKNKVIWLL 264
Cdd:cd17325 139 LGGLLAdalgyraPFLVCAALALLAL--------VLALLLLPE------PRPPPNKRAVSAARLRSGLRLLLRDRRLLAL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 265 CFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRalVACVSLGLIIVSLEFY 344
Cdd:cd17325 205 FLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKP--LILIGLLLSAVALLLL 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 345 QNATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFaYLIGDSFAKLGLGMIADgtpifgLTGWKG 424
Cdd:cd17325 283 PLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA-FSLGMVLGPLLGGFLYD------AFGFAT 355
|
410
....*....|....*...
gi 515661629 425 TFAALDTSAAICIVLLLF 442
Cdd:cd17325 356 PFLAAAALLLLAAVLFLL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
23-454 |
1.94e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.02 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 23 MWFKPFLQSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFML 102
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 103 VLSGIAMLGFSFSmgggsASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRgSYLGLWNMSHNVGGAGAAGVALFG 182
Cdd:COG0738 81 LLMALGLLLFALA-----PSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAA-SRLNLLHAFFSLGALLGPLLGGLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 183 ANYLFDGNVVGMFVFPSIIAIVVGFIGMRFGNDspeayglgtveelfdeEISEEDTIAEENQMTKKEIFveyilKNKVIW 262
Cdd:COG0738 155 ILLGLSLSWHLPYLILAVLLLLLALLFLRSKLP----------------EIEEEEEEAAGSAASLKSLL-----KNPRLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 263 LLCFAnIFLY-IVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRALVACVSLGLIIVSL 341
Cdd:COG0738 214 LGGLA-IFLYvGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 342 EFYqnATSEFMYLASLFVLGFLVfGPQLLIGVAAVGFVPKKAISVADGVKGTFAYlIGDSFAKLGLGMIADgtpifgLTG 421
Cdd:COG0738 293 ALL--APGPWLALIGLALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGI-VGGAIGPPLIGFLAD------AFG 362
|
410 420 430
....*....|....*....|....*....|...
gi 515661629 422 WKGTFAALdtsaAICIVLLLFVAVAEEKKIRHA 454
Cdd:COG0738 363 LRAAFLVP----LVCYLLILLLALALKRKRRKK 391
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
67-374 |
4.93e-08 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 55.01 E-value: 4.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 67 LGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGFSF-SMGGGSASLFMMVAFYALSGFFQSTGGPSSY 145
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVlTEWLHFYNKYLYCILWVLNGLLQSTGWPCVV 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 146 STITKWTPRNKRGSYLGLWNMSHNVggagaagvalfganylfdGNVVGMFVFPSIIaivvgfigmRFGNdspEAYGLGTV 225
Cdd:cd17342 145 AIMGNWFGKSSRGFVLGLWSACASV------------------GNIIGALLASSVL---------DYGY---EYAFLVTS 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 226 EELFDEEISeedtiaeenqmtkkeIFVEYILKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFE 305
Cdd:cd17342 195 SLLFAGAIV---------------VFFGLLSSPPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYD 259
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 306 VGALVGTLMWGYLSDLAnGRRALVACVSLGLIIVSLEFYQNATSE-FMYLASLFVLGFLVFGPQLLIGVA 374
Cdd:cd17342 260 VGGIIGGIVAGYISDRM-GSRSPVVVVMLLLAIPSLFVYSHSPSDkVLNAFVMTITGFFIGGPANLISSA 328
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
56-442 |
5.25e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.55 E-value: 5.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 56 MISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGFSFSmgggsASLFMMVAFYALSGF 135
Cdd:cd17475 22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV-----GSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 136 FQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVA-LFGANYlfdgNVVGMFVFPSIIAIVVGFIGMRFGN 214
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLpPLALHY----GWRAAFVVAGLVSILAAVLFWLFYR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 215 DSPEAYGLGTVEELFDEEISEedtiaeenqmtkkeifveyILKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSK 294
Cdd:cd17475 173 EPPAASAATESASTLLRSLKE-------------------VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 295 ETAISGFTLFEVGALVGTLMWGYLSD-LANGRR----ALVACVSLGLIIVSLEFYQNATSEFMYLAsLFVLGFLVFGPQL 369
Cdd:cd17475 234 VAAGALLAVAQLGGALGRIGLGRVSDrVFGGRRrpvlVITAAIAAAALLVLSLLSPGTPLWLLVLL-LILLGLFAIGWNG 312
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515661629 370 LIGVAAVGFVPKKAISVADGVKGTFAYLigdsfaklglgMIADGTPIFGL-----TGWKGTFAALdtSAAICIVLLLF 442
Cdd:cd17475 313 LYLTLVAESAGPEQAGTALGLANTINFI-----------GIAIGPPLFGLlvdatHSYAPAWLAL--ALLLVLAALLL 377
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
60-429 |
6.99e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.14 E-value: 6.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 60 YGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGFSFSmgggsASLFMMVAFYALSGFFQST 139
Cdd:cd17316 31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL-----PTPILLLVLRFLQGIGIGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 140 GGPSSYSTITKWTPRNKRGSYLGLWNMSHNVggagaagvalfganylfdGNVVGMFVFPSIIAIVVGFIGMRFgndspeA 219
Cdd:cd17316 106 EYPGASTYVAEFAPSKRRGFALGLLQSGWAL------------------GALLAALVASLLIPLLSGDWGWRI------L 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 220 YGLGTVEELFdeeiseedtiaeenqmtkkeifVEYILKNkvIWLLCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAIS 299
Cdd:cd17316 162 FLIGALPALL----------------------ALLLRRR--TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 300 GFTLFEVGALVGTLMWGYLSDLANGRRALVACVSLGLIIVSLEFYQNATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFV 379
Cdd:cd17316 218 YLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELF 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 515661629 380 PKKAISVADGVKGTFAYLIGdSFAKLGLGMIADGTPIFGLTGWKGTFAAL 429
Cdd:cd17316 298 PTEVRATGVGLSYNLGRLGG-GGAPPLIALLLASTGGTGVPALILALLAI 346
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
34-446 |
1.71e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 53.39 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 34 VVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGFS 113
Cdd:cd17328 3 VLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 114 FsmgggSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVggagaagvaLFGANYLFDGNVVG 193
Cdd:cd17328 83 F-----APNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPL---------GSGLGYVVGGLVAQ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 194 M-------FVFPSIIAIVVGFIGMRFGNDSPEAyglgtveelfdeeiSEEDTIAEENQMTKKEIFVEYILKNKVIWLLCF 266
Cdd:cd17328 149 AtggwrwaFRVTGVLGVLLAILLLLFVREPPRG--------------AAEGGVMAKSTATSFLADLKALAKNPSFILSTL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 267 ANIFLYIVRIGIDQW--STVYAYQELGLSKETAISGF--TLFEVGALVGTLMWGYLSDLANGR----RALVACVSLGLII 338
Cdd:cd17328 215 GFTAVSFVTGALAFWapTFFLRAFGVGDLSSADVGLIfgAITCIAGVLGVLLGGILADRLRRKtpraDPLVCAVGLLAAA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 339 VSLEFYQNATSEFMYLASLFVLG--FLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGDSFAKLGLGMIADGTPI 416
Cdd:cd17328 295 PFLFLALVLALSNLLLAWVLLFLgeFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQ 374
|
410 420 430
....*....|....*....|....*....|
gi 515661629 417 FGLTGwKGTFAALDTSAAICIVLLLFVAVA 446
Cdd:cd17328 375 NKDSP-LAEAASLQYALLLCSFVLVLGGFF 403
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-170 |
3.06e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 49.20 E-value: 3.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 15 LPVETRRKMWFKPFLQSYLVVFIGYLTMYLIrknFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNT 94
Cdd:COG2814 196 LRGSLRELLRRPRLLLLLLLAFLLGFGFFAL---FTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR 272
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515661629 95 KQFLPFMLVLSGIAMLGFSFSmgggsASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNV 170
Cdd:COG2814 273 RRLLLIGLLLLALGLLLLALA-----GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
58-362 |
6.45e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 6.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 58 STYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTK--QFLPFMLVLSGIAMLG----FSFSMGGGSASLFMMVAFYA 131
Cdd:COG2211 39 DVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgRRRPWILIGAIPLALSfvllFTAPDLSPTGKLIYALVTYL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 132 LSGFFQSTGGPSSYSTITKWTP-RNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLFDGNVVGMFVFPSIIAIV--VGFI 208
Cdd:COG2211 119 LLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLglLAFL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 209 GMRFGndspeayglgtveelfdeeiSEEDTIAEENQMTKKEIFVEyILKNKVIWLLCFANIFLYIVRIGIDQWSTVYAYQ 288
Cdd:COG2211 199 LTFFG--------------------TKERPVPEEEKVSLKESLKA-LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY 257
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515661629 289 ELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRALVACVSLGLIIVSLEFYQNATSEFMYLASLFVLGF 362
Cdd:COG2211 258 VLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGI 331
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
193-367 |
1.38e-05 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 47.30 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 193 GMFVFPSIIAIVVGFIgMRFGNDSPEAyglgtveelfdeEISEEDTIAEENQMTKKEIFVEYILKNKVIWLLCFanIFLY 272
Cdd:cd17371 158 VLFLLGALPALLVLFI-RRFVKEPPQW------------QAARAARRHFADRPSLRELFSPPLLRTTLLASLLA--TGAL 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 273 IVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLAnGRRALVACVSLG--LIIVSLEFYQNATSE 350
Cdd:cd17371 223 GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI-GRRNNFALFALGsaISILLYFFLPLSPTL 301
|
170
....*....|....*..
gi 515661629 351 FMYLasLFVLGFLVFGP 367
Cdd:cd17371 302 ILIL--GFPLGFFASGP 316
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
26-170 |
5.02e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.26 E-value: 5.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 26 KPFLQSYLVVFIGYLTMYLIRKNFNVaqnDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLS 105
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPL---YAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515661629 106 GIAMLGFSFSmgggsASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNV 170
Cdd:cd17325 276 AVALLLLPLA-----TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
264-450 |
6.54e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 6.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 264 LCFANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRALVAcvSLGLIIVSLEF 343
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI--GLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 344 YQNATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGdsfaklGLGMIADGTpIFGLTGWK 423
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGA------ALGPLLGGL-LASLFGWR 151
|
170 180
....*....|....*....|....*..
gi 515661629 424 GTFAALDTSAAICIVLLLFVAVAEEKK 450
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESK 178
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
261-441 |
3.06e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 3.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 261 IWLLCFANIFLYIvriGIDQWsTVYAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRALV-----ACVSLG 335
Cdd:cd17365 176 LWVTFFMGLLLVY---LLNSW-LPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLAlffalGAVSLA 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 336 LIIVSlefyqnATSEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVKGTFAYLIGDSFAKLGLGMIADGTP 415
Cdd:cd17365 252 LLGVS------PASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLG 325
|
170 180
....*....|....*....|....*.
gi 515661629 416 IFGLtgwkgtFAALDTSAAICIVLLL 441
Cdd:cd17365 326 PESV------FLALAIPAALGALAVL 345
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
33-325 |
3.94e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 42.62 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 33 LVVFIGYLTMYLIRKNFNVAQ-NDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLG 111
Cdd:cd17327 8 PLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 112 FSFSMGGGSaslfmMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLFDGNV 191
Cdd:cd17327 88 TAAVKNFGG-----LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILGVGGL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 192 VG---MFVFPSIIAIVVGFIGMRFGNDSPEAYGLGTVEE--LFDEEISEEDTIAEENQMTKKEIfvEYILKNKVIWLLCF 266
Cdd:cd17327 163 AGwrwLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEkeLAVERLRANQTGKGDQKFKWKQI--KEAFKDPRTWLLFL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 515661629 267 ANIFLYIVRIGIDQWSTVYAYQELGLSKETAISGFTLFEVGAlVGTLMWGYLSDLANGR 325
Cdd:cd17327 241 FFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGA-VSLLIAALLSDRFKKR 298
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
239-368 |
6.94e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.74 E-value: 6.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 239 IAEENQMTKKEIFVEYILKNKVIWLLCFA----NIFLYIVRIgidqWSTVYAYQELGLSKETAISGFTLFEVGALVGTLM 314
Cdd:cd17369 208 AKEAGQVVRAPLVEVLRRHWRALLLAIGLrlaeNVLFYLFTT----FALSYATQTLGVDRSTVLLAVLIASVVAAITIPL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 315 WGYLSDLAnGRRALVACVSLGLIIVSLEFYQ--NATSEFMYLASLFVLGF----LVFGPQ 368
Cdd:cd17369 284 FGWLSDRV-GRRPVYLAGALLAALFAFPFFWllDTGSTWLIVLAAVVVLGvlhgMMYGPQ 342
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
31-167 |
1.59e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.56 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 31 SYLVVFIGYLTMYLIrknfNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAML 110
Cdd:COG0477 19 LALGTFLEGLDFTIV----NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASL 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 515661629 111 GFSFSMgggsaSLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMS 167
Cdd:COG0477 95 LCGLAP-----SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAA 146
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
49-362 |
2.19e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 40.29 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 49 FNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADGKNTKQflpfMLVLSGIaMLGFSFSMGGGSASLFMMV- 127
Cdd:cd17353 22 WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRK----AILIGGI-LFGLGFILSAFAISLPLLFl 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 128 AFYALSGFFQSTGGPSSYSTITKWTPrNKRGSYLGLWNMSHNVGGAGAAGVALFGANYLfdgNVVGMFVFPSIIAIVVGF 207
Cdd:cd17353 97 GYGVLGGIGAGIGYITPVSTAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTV---GVPTTFLILGIIFLIIIV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 208 IGMRFGNDSPEAYGLGTVEelfdeeISEEDTIAEENQMTKKEIfveyiLKNK---VIWLLCFANIFLYIVRIGIdqwSTV 284
Cdd:cd17353 173 IGAFLIRDPPKGWVPPGVD------PLANNAENSPRDYTPREM-----LRTPtfwLLWLMFFLNATAGLMLIGQ---AKP 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515661629 285 YAYQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRAL-VACVSLGLIIVSLEFYQNATSEFMYLASLFVLGF 362
Cdd:cd17353 239 IGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLsIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCY 317
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
9-170 |
2.20e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.09 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 9 RKPTLDLPVETRRKMWFKPFLQSYLVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYY 88
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 89 ADGKNTKQFLPFMLVLSGIAMLGFSFSmgGGSASLFMMVAFYALSGFFQSTGGPSSYSTITKWTPRNKRGSYLGLWNMSH 168
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALGLLLL--SLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAG 336
|
..
gi 515661629 169 NV 170
Cdd:pfam07690 337 SL 338
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
33-414 |
3.27e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.56 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 33 LVVFIGYLTMYLIRKNFNVAQNDMISTYGLSMTDLGLIGLGFSITYGIGKTVVSYYADgkntkQFLPFMLVLSGIAMLGF 112
Cdd:cd17355 6 AVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLD-----RFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 113 SFSMGGGSASLFMMVAFYALSGFFQS-TGGPSSYSTITKWTPRNKRGSYLGLwnmshnvggagaagvalfganyLFDGNV 191
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAgTLAAVAFATVAAWWFERRRGLALGI----------------------LTAGGG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 192 VGMFVFPSIIAIVVGFIGMR-------------------FGNDSPEayGLGTVEELFDEEISEEDTIAEenqmtkkeifv 252
Cdd:cd17355 139 LGSLVFLPLGAALIEAFGWRtallvlallallvlvpvllLLRRRPA--DLALRAYDDASPASPGSTLKE----------- 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 253 eyILKNKVIWLLCFANIFLYIVRIGIDQWSTVYAyQELGLSKETAISGFTLFEVGALVGTLMWGYLSDLANGRRalVACV 332
Cdd:cd17355 206 --ALRSASFWLLALAFFLCGFAVVGLIVHLVPYL-ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRR--LLAA 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 333 SLGLIIVSLEFYQNAT-SEFMYLASLFVLGFLVFGPQLLIGVAAVGFVPKKAISVADGVkGTFAYLIGDSFAKLGLGMIA 411
Cdd:cd17355 281 SYALRALGLALLLLLPfPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGL-VFAPHQLGSALGPWLGGLLY 359
|
...
gi 515661629 412 DGT 414
Cdd:cd17355 360 DRT 362
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
195-364 |
6.71e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.77 E-value: 6.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 195 FVFPSIIAIVVGFIGMRFGNDSPeayglgtveelfdeeiseeDTIAEENQMTKKeifVEYILKNKVIWLLCFANIFLYIV 274
Cdd:cd17341 163 FFVPGILLAIAAVLVLLFGDDLP-------------------TGKASALEFLKV---QLAVLKNYRTWILSLLYGVTFGS 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 275 RIGIDQWSTVYAYQELGLSKETAIsgfTLFEVGALVGTLM---WGYLSDLANGRR---ALVACVSLGLIIVSLEFYQNAT 348
Cdd:cd17341 221 FVGFSNVLPTYFKTRFGLPLVTAG---ILAALFPLAGALArpaGGWLSDRFGGRRrlwWLFIVMTIGAALLSLSLPTSGT 297
|
170
....*....|....*.
gi 515661629 349 SEFMYLASLFVLGFLV 364
Cdd:cd17341 298 NLVLFLALFVALGLGA 313
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
17-162 |
8.77e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.57 E-value: 8.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 17 VETRRKMWFKPFlqsylvvfIGYLTMYLIRKNFNVAQNDMI-------------STYGLSMTD----------------- 66
Cdd:TIGR00894 4 VFASTKLPYFCS--------FRLFLSFLLHICNVIIIAQRIclsltmvamvnkeNSTDLACLSaeneldniknpnfkwsg 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515661629 67 --LGLIGLGFSITYGIGKTVVSYYADGKNTKQFLPFMLVLSGIAMLGFSFSMGGGSAslfMMVAFYALSGFFQSTGGPSS 144
Cdd:TIGR00894 76 alQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIA---LVVFCRVIQGLAQGSVSPAT 152
|
170
....*....|....*...
gi 515661629 145 YSTITKWTPRNKRGSYLG 162
Cdd:TIGR00894 153 HKIIVKWAPPKERSRLLG 170
|
|
| |
