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Conserved domains on  [gi|515665264|ref|WP_017097864|]
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MULTISPECIES: universal stress protein UspE [Vibrio]

Protein Classification

universal stress protein UspE( domain architecture ID 11485249)

universal stress protein UspE is a tandem-type universal stress protein (USP) that consists of two Usp domains and is required for resistance to DNA-damaging agents; enhances the rate of cell survival during prolonged exposure to stress agents

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 2-307 0e+00

universal stress protein UspE; Provisional


:

Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 565.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264   2 SIYNKILVVADINHDEQPALVRAIQLAKKSTStsHITFFLSIYDFSYDMTSMLSVDERDAMRKGVIHQREIWMNKVAAPY 81
Cdd:PRK11175   1 AKYQNILVVIDPNQDDQPALRRAVYLAQRNGG--KITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264  82 LDDSIEFNVQVVWHNRPYEAIIAEVYSGEHDILIKGTRKHDTLESVIFTPTDWHLLRKCPSPVLLVKNDFWPEHAKIYAS 161
Cdd:PRK11175  79 LDAGIPIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264 162 VHVGSETEAHLELNDTMVDRLLEITGRL-DAEPLLVNAYPVTPANITIELPEFDPTSYTDAVRGHHLTAMKALRQKHGMS 240
Cdd:PRK11175 159 VNVASEEPYHDALNEKLVEEAIDLAEQLnHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGID 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515665264 241 EEQTVVEQGLPEDVIPRVASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVLALKPSGYVS 307
Cdd:PRK11175 239 EEQTHVEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
 
Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 2-307 0e+00

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 565.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264   2 SIYNKILVVADINHDEQPALVRAIQLAKKSTStsHITFFLSIYDFSYDMTSMLSVDERDAMRKGVIHQREIWMNKVAAPY 81
Cdd:PRK11175   1 AKYQNILVVIDPNQDDQPALRRAVYLAQRNGG--KITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264  82 LDDSIEFNVQVVWHNRPYEAIIAEVYSGEHDILIKGTRKHDTLESVIFTPTDWHLLRKCPSPVLLVKNDFWPEHAKIYAS 161
Cdd:PRK11175  79 LDAGIPIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264 162 VHVGSETEAHLELNDTMVDRLLEITGRL-DAEPLLVNAYPVTPANITIELPEFDPTSYTDAVRGHHLTAMKALRQKHGMS 240
Cdd:PRK11175 159 VNVASEEPYHDALNEKLVEEAIDLAEQLnHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGID 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515665264 241 EEQTVVEQGLPEDVIPRVASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVLALKPSGYVS 307
Cdd:PRK11175 239 EEQTHVEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 157-302 2.29e-67

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 207.51  E-value: 2.29e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264 157 KIYASVHVGSETEAHLELNDTMVDRLLEITGRLDAEPLLVNAYPVTPANITIELPEFDPTSYTDAVRGHHLTAMKALRQK 236
Cdd:cd23660    3 RILVAVDPSNEEEYHEDLNLRLIELAYSLAAQLKAELHLVSAWPVTPENIAIELPEFDPTEYVDAIRGRHLEAMKALRQK 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515665264 237 HGMSEEQTVVEQGLPEDVIPRVASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVLALKP 302
Cdd:cd23660   83 FGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLALKP 148
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
179-298 4.60e-18

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 78.81  E-value: 4.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264 179 VDRLLEITGRLDAEPLLVNAYPVTPAnitielPEFDPTSYTDAVRGHHLTAMKALRQK---HGMsEEQTVVEQGLPEDVI 255
Cdd:COG0589   19 LEYAAELAKALGAELHLLHVVDPPPS------AAAGPEELEEELREEAEEALEEAAERleeAGV-EVETVVREGDPAEAI 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 515665264 256 PRVASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVL 298
Cdd:COG0589   92 LEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVL 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 179-301 4.37e-15

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 70.90  E-value: 4.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264  179 VDRLLEITGRLDAEPLLVNAYPVTPANITIELPEFDPTSYTDAVRGHHLTAMKALRQKHGMSEEQTVVEQGLPEDVIPRV 258
Cdd:pfam00582  15 LEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEVVVVVGDPAEEILEV 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 515665264  259 ASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVLALK 301
Cdd:pfam00582  95 AEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
 
Name Accession Description Interval E-value
PRK11175 PRK11175
universal stress protein UspE; Provisional
 2-307 0e+00

universal stress protein UspE; Provisional


Pssm-ID: 236871 [Multi-domain]  Cd Length: 305  Bit Score: 565.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264   2 SIYNKILVVADINHDEQPALVRAIQLAKKSTStsHITFFLSIYDFSYDMTSMLSVDERDAMRKGVIHQREIWMNKVAAPY 81
Cdd:PRK11175   1 AKYQNILVVIDPNQDDQPALRRAVYLAQRNGG--KITAFLPIYDFSYEMTTLLSPDEREAMRQGVISQRTAWIREQAKPY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264  82 LDDSIEFNVQVVWHNRPYEAIIAEVYSGEHDILIKGTRKHDTLESVIFTPTDWHLLRKCPSPVLLVKNDFWPEHAKIYAS 161
Cdd:PRK11175  79 LDAGIPIEIKVVWHNRPFEAIIQEVIAGGHDLVVKMTHQHDKLESVIFTPTDWHLLRKCPCPVLMVKDQDWPEGGKILVA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264 162 VHVGSETEAHLELNDTMVDRLLEITGRL-DAEPLLVNAYPVTPANITIELPEFDPTSYTDAVRGHHLTAMKALRQKHGMS 240
Cdd:PRK11175 159 VNVASEEPYHDALNEKLVEEAIDLAEQLnHAEVHLVNAYPVTPINIAIELPEFDPSVYNDAIRGQHLLAMKALRQKFGID 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515665264 241 EEQTVVEQGLPEDVIPRVASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVLALKPSGYVS 307
Cdd:PRK11175 239 EEQTHVEEGLPEEVIPDLAEHLDAELVILGTVGRTGLSAAFLGNTAEHVIDHLNCDLLAIKPDGYVS 305
USP-E_repeat2 cd23660
Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP ...
 157-302 2.29e-67

Universal stress protein E, repeat 2; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467506  Cd Length: 148  Bit Score: 207.51  E-value: 2.29e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264 157 KIYASVHVGSETEAHLELNDTMVDRLLEITGRLDAEPLLVNAYPVTPANITIELPEFDPTSYTDAVRGHHLTAMKALRQK 236
Cdd:cd23660    3 RILVAVDPSNEEEYHEDLNLRLIELAYSLAAQLKAELHLVSAWPVTPENIAIELPEFDPTEYVDAIRGRHLEAMKALRQK 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515665264 237 HGMSEEQTVVEQGLPEDVIPRVASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVLALKP 302
Cdd:cd23660   83 FGIDEEQTHVLEGLPEEVIPDFAEELDADIVVLGTVARTGLSGALIGNTAEHVLDHLNCDLLALKP 148
USP-E_repeat1 cd23943
Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP ...
 4-148 6.78e-61

Universal stress protein E, repeat 1; UspE is a tandem-type USP that consists of two USP domains. The UspE expression levels of Escherichia coli become elevated in response to oxidative stress and DNA damaging agents, including exposure to mitomycin C, cadmium, and hydrogen peroxide. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467508  Cd Length: 143  Bit Score: 190.84  E-value: 6.78e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264   4 YNKILVVADINHDEQPALVRAIQLAKKSTSTshITFFLSIYDFSYDMTSMLSVDERDAMRKGVIHQREIWMNKVAAPYLD 83
Cdd:cd23943    1 YQNMLVVIDPNQDDQPALRRAVYLVQRIGGK--IKAFLPIYDLSYEMTTLLSPDERTAMRQGVISQRTAWIREQAKYYLE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515665264  84 DSIEFNVQVVWHNRPYEAIIAEVYSGEHDILIKGTRKHDTLESVIFTPTDWHLLRKCPSPVLLVK 148
Cdd:cd23943   79 AGIPIEIKVVWHNRPFEAIIQEVIAGNHDLVLKMAHQHDRLESLIFTPTDWHLLRKCPSPVWMVK 143
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
179-298 4.60e-18

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 78.81  E-value: 4.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264 179 VDRLLEITGRLDAEPLLVNAYPVTPAnitielPEFDPTSYTDAVRGHHLTAMKALRQK---HGMsEEQTVVEQGLPEDVI 255
Cdd:COG0589   19 LEYAAELAKALGAELHLLHVVDPPPS------AAAGPEELEEELREEAEEALEEAAERleeAGV-EVETVVREGDPAEAI 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 515665264 256 PRVASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVL 298
Cdd:COG0589   92 LEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVL 134
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 179-301 4.37e-15

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 70.90  E-value: 4.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264  179 VDRLLEITGRLDAEPLLVNAYPVTPANITIELPEFDPTSYTDAVRGHHLTAMKALRQKHGMSEEQTVVEQGLPEDVIPRV 258
Cdd:pfam00582  15 LEWAAELAKARGAELILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKVEVVVVVGDPAEEILEV 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 515665264  259 ASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVLALK 301
Cdd:pfam00582  95 AEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 6-147 1.61e-14

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 69.30  E-value: 1.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264   6 KILVVADINHDEQPALVRAIQLAKKSTSTshITFFLSIYDFSYDMTSMLSVDERDAMRkgviHQREIWMNKVAAPYLDDS 85
Cdd:cd00293    1 KILVAVDGSEESERALEWALELAKRPGAE--LTLLHVVDPPPSSSLSGGLEELADELK----EEAEELLEEAKKLAEEAG 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515665264  86 IEFNVQVVWHNrPYEAIIAEVYSGEHDILIKGTRKHDTLESVIFTPTDWHLLRKCPSPVLLV 147
Cdd:cd00293   75 VEVETIVVEGD-PAEAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVLVV 135
UspA COG0589
Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];
4-147 1.75e-14

Nucleotide-binding universal stress protein, UspA family [Signal transduction mechanisms];


Pssm-ID: 440354  Cd Length: 136  Bit Score: 69.18  E-value: 1.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264   4 YNKILVVADINHDEQPALVRAIQLAKKSTSTSHItffLSIYDfSYDMTSMLSVDERDAMRKgvihQREIWMNKVAAPYLD 83
Cdd:COG0589    2 YKRILVPTDGSEEAERALEYAAELAKALGAELHL---LHVVD-PPPSAAAGPEELEEELRE----EAEEALEEAAERLEE 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515665264  84 DSIEFNVQVVwHNRPYEAIIAEVYSGEHDILIKGTRKHDTLESVIFTPTDWHLLRKCPSPVLLV 147
Cdd:COG0589   74 AGVEVETVVR-EGDPAEAILEAAEELDADLIVMGSRGRSGLRRLLLGSVAERVLRHAPCPVLVV 136
Usp pfam00582
Universal stress protein family; The universal stress protein UspA is a small cytoplasmic ...
 7-148 1.61e-13

Universal stress protein family; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae UspA reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, though UspA lacks ATP-binding activity.


Pssm-ID: 425765 [Multi-domain]  Cd Length: 137  Bit Score: 66.66  E-value: 1.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264    7 ILVVADINHDEQPALVRAIQLAKKSTSTshITFFLSIYDFSYDMTSMLSVDERDAMRKGVIHQREIWMNKVAAPYLDDSI 86
Cdd:pfam00582   1 ILVAVDGSEESKRALEWAAELAKARGAE--LILLHVIDPPPSGAASLADESAEEEELELELAEAEALAAAAAAEAGGVKV 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 515665264   87 EFnvqVVWHNRPYEAIIAEVYSGEHDILIKGTRKHDTLESVIFTPTDWHLLRKCPSPVLLVK 148
Cdd:pfam00582  79 EV---VVVVGDPAEEILEVAEEEDADLIVMGSRGRSGLSRLLLGSVAEYVLRHAPCPVLVVR 137
USP-like cd00293
universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a ...
 173-298 8.48e-13

universal stress protein (USP) and similar proteins; The universal stress protein (USP) is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity. The crystal structure of Haemophilus influenzae Usp reveals an alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, which binds ATP, although USP lacks ATP-binding activity.


Pssm-ID: 467483 [Multi-domain]  Cd Length: 135  Bit Score: 64.68  E-value: 8.48e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515665264 173 ELNDTMVDRLLEITGRLDAEPLLVNAYPVTPANITIELPEFDPTSYTDAVRgHHLTAMKALRQKHGMSEEqTVVEQGLPE 252
Cdd:cd00293   10 EESERALEWALELAKRPGAELTLLHVVDPPPSSSLSGGLEELADELKEEAE-ELLEEAKKLAEEAGVEVE-TIVVEGDPA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 515665264 253 DVIPRVASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVL 298
Cdd:cd00293   88 EAILEEAKELGADLIVMGSRGRSGLKRLLLGSVSEYVLRHAPCPVL 133
USP_At3g01520-like cd23659
universal stress protein At3g01520 and similar proteins; This subfamily includes plant and ...
 244-298 1.07e-05

universal stress protein At3g01520 and similar proteins; This subfamily includes plant and fungal proteins of unknown function, including Arabidopsis thaliana At3g01520. A. thaliana contains 44 USP domain-containing proteins; the USP domain is found either in a small protein with unknown physiological function or as an N-terminal portion of a multi-domain protein, usually a protein kinase. The gene At3g01520 of Arabidopsis thaliana encodes a 175-residue universal stress protein (USP)-like protein which is widely found in the genomes of bacteria, as well as fungi, protozoa, and plants. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 belongs to the ATP-binding USP subfamily. Universal stress proteins (USPs) are small cytoplasmic bacterial proteins whose expression is enhanced when the cell is exposed to stress agents. USP enhances the rate of cell survival during prolonged exposure to such conditions, and may provide a general "stress endurance" activity.


Pssm-ID: 467505  Cd Length: 143  Bit Score: 44.53  E-value: 1.07e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 515665264 244 TVVEQGLPEDVIPRVASENNAAMVILGTTGRTGLSAVFIGNTAEHVIDKINCDVL 298
Cdd:cd23659   86 VEVVAGDPGEVICKAAEELKADLIVMGSRGLGALKRTLLGSVSDYVVHHSPCPVL 140
USP-A-like cd23657
universal stress protein A and similar proteins; The universal stress protein UspA is a small ...
 225-302 3.61e-04

universal stress protein A and similar proteins; The universal stress protein UspA is a small cytoplasmic bacterial protein whose expression is enhanced several-fold when cellular viability is challenged with heat shock, nutrient starvation, stress agents which arrest cell growth, or DNA-damaging agents. UspA enhances the rate of cell survival during prolonged exposure to such conditions, suggesting that it asserts a general "stress endurance" activity. In general, these proteins form dimers and have domains for nucleotide binding activity. The crystal structure of Haemophilus influenzae UspA reveals an asymmetric dimer with a tertiary alpha/beta fold similar to that of the Methanococcus jannaschii MJ0577 protein, but unlike MJ0577, it lacks ATP-binding activity.


Pssm-ID: 467504  Cd Length: 138  Bit Score: 39.98  E-value: 3.61e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515665264 225 HHLTAMKALRQKHGMSEEQTVVEQGLPEDVIPRVASENNAAMVILGTTGRTGLSavFIGNTAEHVIDKINCDVLALKP 302
Cdd:cd23657   63 MLEEALKNLSELAGYPVDHTFIGYGDLKEEILEVAKKHNVDLIVCGHHGDFGLS--LLGSSARAVLNSAPCDVLIVPL 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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