NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|515667310|ref|WP_017099910|]
View 

MULTISPECIES: Lrp/AsnC family transcriptional regulator [Vibrio]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
8-146 5.82e-56

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 171.89  E-value: 5.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515667310   8 IDAVDKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKRVALLNPEKLDLSFTAFVLIKTSDHSHEwyg 87
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD--- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515667310  88 RFVNTVSEFPEVMEFYRMAGEYDYMMKVQVKDMKCFDDFYKRLVNSIDGISNVTSTFAM 146
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
8-146 5.82e-56

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 171.89  E-value: 5.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515667310   8 IDAVDKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKRVALLNPEKLDLSFTAFVLIKTSDHSHEwyg 87
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD--- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515667310  88 RFVNTVSEFPEVMEFYRMAGEYDYMMKVQVKDMKCFDDFYKRLVNSIDGISNVTSTFAM 146
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 8-117 4.94e-42

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 135.72  E-value: 4.94e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515667310     8 IDAVDKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKRVALLNPEKLDLSFTAFVLIKTsdHSHEWYG 87
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 515667310    88 RFVNTVSEFPEVMEFYRMAGEYDYMMKVQV 117
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
8-157 2.13e-25

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 94.83  E-value: 2.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515667310   8 IDAVDKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKRVALLNPEKLDLSFTAFVLIKTSDHSHEWYG 87
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515667310  88 RFVNTVSEFPEVMEFYRMAGEYDYMMKVQVKDMKCfddfYKRLVNS----IDGISNVTSTFAMEPLKYTTALPL 157
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSA----YRKLLGEtllrLPGVNDTRTYVVMEEVKQTNRLVI 161
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 74-147 9.49e-22

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 82.96  E-value: 9.49e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515667310   74 VLIKTSDHSheWYGRFVNTVSEFPEVMEFYRMAGEYDYMMKVQVKDMKCFDDFYKRLVNSIDGISNVTSTFAME 147
Cdd:pfam01037   1 VEVKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-57 5.24e-09

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 49.99  E-value: 5.24e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 515667310   9 DAVDKKILGLLQEDStLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKR 57
Cdd:cd00090    6 DPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
8-146 5.82e-56

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 171.89  E-value: 5.82e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515667310   8 IDAVDKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKRVALLNPEKLDLSFTAFVLIKTSDHSHEwyg 87
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD--- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 515667310  88 RFVNTVSEFPEVMEFYRMAGEYDYMMKVQVKDMKCFDDFYKRLVNSIDGISNVTSTFAM 146
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 8-117 4.94e-42

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 135.72  E-value: 4.94e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515667310     8 IDAVDKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKRVALLNPEKLDLSFTAFVLIKTsdHSHEWYG 87
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 515667310    88 RFVNTVSEFPEVMEFYRMAGEYDYMMKVQV 117
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
8-157 2.13e-25

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 94.83  E-value: 2.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515667310   8 IDAVDKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKRVALLNPEKLDLSFTAFVLIKTSDHSHEWYG 87
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515667310  88 RFVNTVSEFPEVMEFYRMAGEYDYMMKVQVKDMKCfddfYKRLVNS----IDGISNVTSTFAMEPLKYTTALPL 157
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSA----YRKLLGEtllrLPGVNDTRTYVVMEEVKQTNRLVI 161
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 74-147 9.49e-22

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 82.96  E-value: 9.49e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515667310   74 VLIKTSDHSheWYGRFVNTVSEFPEVMEFYRMAGEYDYMMKVQVKDMKCFDDFYKRLVNSIDGISNVTSTFAME 147
Cdd:pfam01037   1 VEVKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
12-54 2.77e-15

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 65.53  E-value: 2.77e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 515667310   12 DKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGII 54
Cdd:pfam13412   3 DRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
9-49 5.73e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 64.70  E-value: 5.73e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 515667310    9 DAVDKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLE 49
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 9-57 5.24e-09

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 49.99  E-value: 5.24e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 515667310   9 DAVDKKILGLLQEDStLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKR 57
Cdd:cd00090    6 DPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 8-143 3.12e-07

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 47.01  E-value: 3.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515667310   8 IDAVDKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKRVALLNPEKLDLSFTAFVLIKTSdhSHEWYG 87
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILK--SAKDYP 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 515667310  88 RFVNTVSEFPEVMEFYRMAGEYDYMMKVQVKDMkcfDDFYKRLVNSIDGISNVTST 143
Cdd:PRK11179  85 SALAKLESLDEVVEAYYTTGHYSIFIKVMCRSI---DALQHVLINKIQTIDEIQST 137
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 12-57 2.86e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 37.59  E-value: 2.86e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 515667310  12 DKKILGLLQE-DSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKR 57
Cdd:COG2512   17 ERRVLELLREnGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE 63
HxlR COG1733
DNA-binding transcriptional regulator, HxlR family [Transcription];
26-58 1.96e-03

DNA-binding transcriptional regulator, HxlR family [Transcription];


Pssm-ID: 441339  Cd Length: 108  Bit Score: 36.00  E-value: 1.96e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 515667310  26 SLNDISEAVnLTttpcwKRLKRLEENGIIEKRV 58
Cdd:COG1733   44 SLPGISQKM-LT-----QRLRELEEDGLVERTV 70
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
12-57 2.66e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.39  E-value: 2.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 515667310  12 DKKILGLLQEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKR 57
Cdd:COG3398   99 PRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERE 144
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
14-57 3.39e-03

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 34.49  E-value: 3.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 515667310    14 KILGLLqEDSTLSLNDISEAVNLTTTPCWKRLKRLEENGIIEKR 57
Cdd:smart00418   1 KILKLL-AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESR 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH