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Conserved domains on  [gi|515674125|ref|WP_017106725|]
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MULTISPECIES: GNAT family N-acetyltransferase [Vibrio]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11441181)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
2-147 1.62e-14

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


:

Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 66.94  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   2 NVTLRAAKHTDLEQLNELMFDLHHHHHIAcpeHFKTAEEIEQEKSIARYLDDPECLVYVALKGELIVGFISghfceLIST 81
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAEGTAT---FETEPPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFAS-----LGPF 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515674125  82 VSKPVQMGSVDE-LFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVEVWDFNSPAKDFYQKMGFTP 147
Cdd:COG1247   73 RPRPAYRGTAEEsIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEE 139
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
2-147 1.62e-14

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 66.94  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   2 NVTLRAAKHTDLEQLNELMFDLHHHHHIAcpeHFKTAEEIEQEKSIARYLDDPECLVYVALKGELIVGFISghfceLIST 81
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAEGTAT---FETEPPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFAS-----LGPF 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515674125  82 VSKPVQMGSVDE-LFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVEVWDFNSPAKDFYQKMGFTP 147
Cdd:COG1247   73 RPRPAYRGTAEEsIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEE 139
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 27-145 4.51e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 56.76  E-value: 4.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   27 HHIACPEHFKTAEEIEQEKSIARYLDDPECLVYVALKGElIVGFISGHFCElistvsKPVQMGSVDELFVLPEYRKADVA 106
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGE-LVGFASLSIID------DEPPVGEIEGLAVAPEYRGKGIG 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 515674125  107 QMLFNRVESTFEDYGVTQVFVEVWDFNSPAKDFYQKMGF 145
Cdd:pfam00583  78 TALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 58-128 3.43e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.26  E-value: 3.43e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515674125  58 VYVALKGELIVGFISGHFCELISTVskpvqmGSVDELFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVE 128
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGGDT------AYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 44-146 1.42e-05

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 42.22  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125  44 EKSIARYLDDPECLVYVALKGELIVGFI----SGHfcelistvskpvqMGSVDELFVLPEYRKADVAQMLFNRVESTFED 119
Cdd:PRK03624  33 EMDIERKLNHDPSLFLVAEVGGEVVGTVmggyDGH-------------RGWAYYLAVHPDFRGRGIGRALVARLEKKLIA 99

                         90       100
                 ....*....|....*....|....*..
gi 515674125 120 YGVTQVFVEVWDFNSPAKDFYQKMGFT 146
Cdd:PRK03624 100 RGCPKINLQVREDNDAVLGFYEALGYE 126
 
Name Accession Description Interval E-value
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
2-147 1.62e-14

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 66.94  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   2 NVTLRAAKHTDLEQLNELMFDLHHHHHIAcpeHFKTAEEIEQEKSIARYLDDPECLVYVALKGELIVGFISghfceLIST 81
Cdd:COG1247    1 EMTIRPATPEDAPAIAAIYNEAIAEGTAT---FETEPPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFAS-----LGPF 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515674125  82 VSKPVQMGSVDE-LFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVEVWDFNSPAKDFYQKMGFTP 147
Cdd:COG1247   73 RPRPAYRGTAEEsIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVLADNEASIALYEKLGFEE 139
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 29-147 3.82e-13

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 62.38  E-value: 3.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125  29 IACPEHFKTAEEIEQ-EKSIARY--LDDPECLVYVALKGELIvGFISghfcelISTVSKPVqmGSVDELFVLPEYRKADV 105
Cdd:COG0454    5 KATPEDINFILLIEAlDAELKAMegSLAGAEFIAVDDKGEPI-GFAG------LRRLDDKV--LELKRLYVLPEYRGKGI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 515674125 106 AQMLFNRVESTFEDYGVTQVFVEVWDFNSPAKDFYQKMGFTP 147
Cdd:COG0454   76 GKALLEALLEWARERGCTALELDTLDGNPAAIRFYERLGFKE 117
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
5-147 3.90e-13

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 62.80  E-value: 3.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   5 LRAAKHTDLEQLNELMFDLhhhhhiacpehFKTAEEieqEKSIARYLDDPEC-LVYVALKGELIVGFISGHFCelisTVS 83
Cdd:COG3153    1 IRPATPEDAEAIAALLRAA-----------FGPGRE---AELVDRLREDPAAgLSLVAEDDGEIVGHVALSPV----DID 62

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515674125  84 KPVQMGSVDELFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVEVwdfNSPAKDFYQKMGFTP 147
Cdd:COG3153   63 GEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLG---DPSLLPFYERFGFRP 123
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 69-148 5.18e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 61.21  E-value: 5.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125  69 GFISGHFCElistvskPVQMGSVDELFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVEVWDFNSPAKDFYQKMGFTPH 148
Cdd:COG0456    1 GFALLGLVD-------GGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEV 73
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 27-145 4.51e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 56.76  E-value: 4.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   27 HHIACPEHFKTAEEIEQEKSIARYLDDPECLVYVALKGElIVGFISGHFCElistvsKPVQMGSVDELFVLPEYRKADVA 106
Cdd:pfam00583   5 YELLSEEFPEPWPDEPLDLLEDWDEDASEGFFVAEEDGE-LVGFASLSIID------DEPPVGEIEGLAVAPEYRGKGIG 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 515674125  107 QMLFNRVESTFEDYGVTQVFVEVWDFNSPAKDFYQKMGF 145
Cdd:pfam00583  78 TALLQALLEWARERGCERIFLEVAADNLAAIALYEKLGF 116
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 50-147 5.43e-11

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 56.92  E-value: 5.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125  50 YLDDPECLVYVALKGELIVGFISGHFCelistvskPVQMGSVDELFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVEV 129
Cdd:COG1246   22 ALEEEIGEFWVAEEDGEIVGCAALHPL--------DEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLT 93

                         90
                 ....*....|....*...
gi 515674125 130 wdfNSPAKDFYQKMGFTP 147
Cdd:COG1246   94 ---TSAAIHFYEKLGFEE 108
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 54-147 2.42e-10

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 54.00  E-value: 2.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   54 PECLVYVALKGELIVGFISGHFCELISTVSKpvqmgsvDELFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVEVwdfN 133
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAE-------LRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELET---T 70

                          90
                  ....*....|....
gi 515674125  134 SPAKDFYQKMGFTP 147
Cdd:pfam13508  71 NRAAAFYEKLGFEE 84
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 32-148 4.62e-10

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 54.20  E-value: 4.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   32 PEHFKTAEEIEQEKSIARYLDDPECLVYVALKGELIVGFIS----GHFCelistvskpvqmgsvdELFVLPEYRKADVAQ 107
Cdd:pfam13673   7 EEGIETFYEFISPEALRERIDQGEYFFFVAFEGGQIVGVIAlrdrGHIS----------------LLFVDPDYQGQGIGK 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 515674125  108 MLFNRVESTFEDYGVTQVFVEVwdfNS--PAKDFYQKMGFTPH 148
Cdd:pfam13673  71 ALLEAVEDYAEKDGIKLSELTV---NAspYAVPFYEKLGFRAT 110
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
42-157 7.53e-08

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 48.26  E-value: 7.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125  42 EQEKSIARYLD--DPECLVYVALKGELIVGFISghfceLISTVSKPVQMGSVdelFVLPEYRKADVAQMLFNRVESTFED 119
Cdd:COG2153   18 EQGVPPYLELDgkDEDARHLLAYDDGELVATAR-----LLPPGDGEAKIGRV---AVLPEYRGQGLGRALMEAAIEEARE 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 515674125 120 YGVTQVFVEVwdfNSPAKDFYQKMGFT-----------PHIqWMRKALN 157
Cdd:COG2153   90 RGARRIVLSA---QAHAVGFYEKLGFVpvgeefleagiPHI-DMRKPLS 134
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
94-159 1.20e-07

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 46.83  E-value: 1.20e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515674125  94 LFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVEVWDFNSPAKDFYQKMGFTPHIQWMRKALNKT 159
Cdd:COG3393   21 VYTHPEYRGRGLASALVAALAREALARGARTPFLYVDADNPAARRLYERLGFRPVGEYATVLFRKP 86
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 58-128 3.43e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.26  E-value: 3.43e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515674125  58 VYVALKGELIVGFISGHFCELISTVskpvqmGSVDELFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFVE 128
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGGDT------AYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 44-146 1.42e-05

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 42.22  E-value: 1.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125  44 EKSIARYLDDPECLVYVALKGELIVGFI----SGHfcelistvskpvqMGSVDELFVLPEYRKADVAQMLFNRVESTFED 119
Cdd:PRK03624  33 EMDIERKLNHDPSLFLVAEVGGEVVGTVmggyDGH-------------RGWAYYLAVHPDFRGRGIGRALVARLEKKLIA 99

                         90       100
                 ....*....|....*....|....*..
gi 515674125 120 YGVTQVFVEVWDFNSPAKDFYQKMGFT 146
Cdd:PRK03624 100 RGCPKINLQVREDNDAVLGFYEALGYE 126
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 1-147 9.53e-05

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 40.37  E-value: 9.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   1 MNVTLRAAKHTDLEQLNELMFDLHHHHHIacPEHFKTAEEIEQE-KSIARYLDDPECLVYVALK---GELIvGFISghfc 76
Cdd:COG1670    6 ERLRLRPLRPEDAEALAELLNDPEVARYL--PGPPYSLEEARAWlERLLADWADGGALPFAIEDkedGELI-GVVG---- 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515674125  77 elISTVSKPVQMGSVDeLFVLPEYRK----ADVAQMLFNRVestFEDYGVTQVFVEVWDFNSPAKDFYQKMGFTP 147
Cdd:COG1670   79 --LYDIDRANRSAEIG-YWLAPAYWGkgyaTEALRALLDYA---FEELGLHRVEAEVDPDNTASIRVLEKLGFRL 147
PRK07757 PRK07757
N-acetyltransferase;
59-145 2.18e-03

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 36.33  E-value: 2.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125  59 YVALKGELIVGFISGHFCElistvskpVQMGSVDELFVLPEYRKADVAQMLFNRVESTFEDYGVTQVFveVWDFNspaKD 138
Cdd:PRK07757  44 YVAEEEGEIVGCCALHILW--------EDLAEIRSLAVSEDYRGQGIGRMLVEACLEEARELGVKRVF--ALTYQ---PE 110


                 ....*..
gi 515674125 139 FYQKMGF 145
Cdd:PRK07757 111 FFEKLGF 117
COG5628 COG5628
Predicted acetyltransferase [General function prediction only];
1-112 8.90e-03

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 444356  Cd Length: 163  Bit Score: 34.91  E-value: 8.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674125   1 MNVTLRAAKHTDLEQLNELM----FDLHHHHHIACPEH--FktaeeieQEKSIARYLDDPECLVYVALKGELIVGFIsgh 74
Cdd:COG5628    1 MKVSIERVTAEDKPILENLYqlylHDLSEFTGILPDADglF-------EYEYLDTYWTDDDRHPYLIYVDGEPAGFA--- 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 515674125  75 fceLISTVSKPVQMGSVDELFVLPEYRK----ADVAQMLFNR 112
Cdd:COG5628   71 ---LVRRLPFLESDYEIAEFFVLRKYRRkgigKRAAHELFKR 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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