|
Name |
Accession |
Description |
Interval |
E-value |
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
307-554 |
1.40e-67 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
:
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 222.44 E-value: 1.40e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 307 ALIIPLRAGNEVVGTIKLYEPKLKLFSTINMSMGEGIAQLLSSQILFSNYQQQQTLLTQAEIKLLHAQVNPHFLFNALNT 386
Cdd:COG3275 100 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNS 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 387 ISAVTRRDPDKARELIQHLSHFFRSNLKQN-INTVKLKDELAHVNAYLTIEKARFTDRLEVEWDIDPQLYESQLPSFTLQ 465
Cdd:COG3275 180 IYSLIREDPEKARELLLKLSDLLRYSLYESdKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQ 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 466 PLVENAIKHGISNMLEGGKVKIYSEAFEGGFKLTVEDNAGNYQ-KPSQDHVGLGMEIVDKRLTNFFGQDSALKIESQPQK 544
Cdd:COG3275 260 PLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQpKKKKKGSGIGLKNVRERLELLYGDKYSLEIESTDGG 339
|
250
....*....|
gi 515674171 545 FTRMSFIIPI 554
Cdd:COG3275 340 GTKVTLKIPL 349
|
|
| 5TM-5TMR_LYT |
pfam07694 |
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ... |
24-194 |
9.04e-64 |
|
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).
:
Pssm-ID: 429599 Cd Length: 170 Bit Score: 206.27 E-value: 9.04e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 24 TPLILPLL-SISSRLSHKISCYVLFSLFCIMGTYFGLQIN-DAIANTRAMGAVMGGLFGGPVVGFAVGFTGGIHRYSLGG 101
Cdd:pfam07694 1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 102 FTDLACAISTTAEGLIGGLLHVYLVRKNKasqLFNPLVVFSVTLFAEIIQMIILLAVAKPFEQSYALVSDIAAPMIIANS 181
Cdd:pfam07694 81 FTALACGISTILAGLIAGLLHRRLKRRRR---LISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157
|
170
....*....|...
gi 515674171 182 VGAALFMSIIQDR 194
Cdd:pfam07694 158 LGTAIFLSILRDR 170
|
|
| GAF_2 |
pfam13185 |
GAF domain; The GAF domain is named after some of the proteins it is found in, including ... |
242-348 |
1.01e-04 |
|
GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
:
Pssm-ID: 433019 [Multi-domain] Cd Length: 137 Bit Score: 42.45 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 242 VGAVAITDREKILAFVGIGDEHHI--PNTPISSQSTLTSMEQNDIIYL-DGKENPYQCSLS-QDCKLGSALIIPLRAGNE 317
Cdd:pfam13185 23 VGFILLVDDDGRLAAWGGAADELSaaLDDPPGEGLVGEALRTGRPVIVnDLAADPAKKGLPaGHAGLRSFLSVPLVSGGR 102
|
90 100 110
....*....|....*....|....*....|.
gi 515674171 318 VVGTIKLYEPKLKLFSTINMSMGEGIAQLLS 348
Cdd:pfam13185 103 VVGVLALGSNRPGAFDEEDLELLELLAEQAA 133
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
307-554 |
1.40e-67 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 222.44 E-value: 1.40e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 307 ALIIPLRAGNEVVGTIKLYEPKLKLFSTINMSMGEGIAQLLSSQILFSNYQQQQTLLTQAEIKLLHAQVNPHFLFNALNT 386
Cdd:COG3275 100 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNS 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 387 ISAVTRRDPDKARELIQHLSHFFRSNLKQN-INTVKLKDELAHVNAYLTIEKARFTDRLEVEWDIDPQLYESQLPSFTLQ 465
Cdd:COG3275 180 IYSLIREDPEKARELLLKLSDLLRYSLYESdKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQ 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 466 PLVENAIKHGISNMLEGGKVKIYSEAFEGGFKLTVEDNAGNYQ-KPSQDHVGLGMEIVDKRLTNFFGQDSALKIESQPQK 544
Cdd:COG3275 260 PLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQpKKKKKGSGIGLKNVRERLELLYGDKYSLEIESTDGG 339
|
250
....*....|
gi 515674171 545 FTRMSFIIPI 554
Cdd:COG3275 340 GTKVTLKIPL 349
|
|
| 5TM-5TMR_LYT |
pfam07694 |
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ... |
24-194 |
9.04e-64 |
|
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).
Pssm-ID: 429599 Cd Length: 170 Bit Score: 206.27 E-value: 9.04e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 24 TPLILPLL-SISSRLSHKISCYVLFSLFCIMGTYFGLQIN-DAIANTRAMGAVMGGLFGGPVVGFAVGFTGGIHRYSLGG 101
Cdd:pfam07694 1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 102 FTDLACAISTTAEGLIGGLLHVYLVRKNKasqLFNPLVVFSVTLFAEIIQMIILLAVAKPFEQSYALVSDIAAPMIIANS 181
Cdd:pfam07694 81 FTALACGISTILAGLIAGLLHRRLKRRRR---LISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157
|
170
....*....|...
gi 515674171 182 VGAALFMSIIQDR 194
Cdd:pfam07694 158 LGTAIFLSILRDR 170
|
|
| His_kinase |
pfam06580 |
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ... |
366-444 |
5.90e-32 |
|
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.
Pssm-ID: 461952 [Multi-domain] Cd Length: 79 Bit Score: 117.93 E-value: 5.90e-32
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515674171 366 AEIKLLHAQVNPHFLFNALNTISAVTRRDPDKARELIQHLSHFFRSNLKQNINTVKLKDELAHVNAYLTIEKARFTDRL 444
Cdd:pfam06580 1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
459-553 |
3.27e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 97.12 E-value: 3.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 459 LPSFTLQPLVENAIKHGISNMLEGGKVKIYSEAFEGGFKLTVEDNAGNYQ------KPSQDHVGLGMEIVDKRLTNFFGQ 532
Cdd:cd16956 1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDpdtlarILIRSSNGLGLNLVDKRLRQAFGN 80
|
90 100
....*....|....*....|.
gi 515674171 533 DSALKIESQPQKFTRMSFIIP 553
Cdd:cd16956 81 DYGLDIECAPGEGTRITIRLP 101
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
464-554 |
2.77e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 46.10 E-value: 2.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 464 LQPLVENAIKHgisnMLEGGKVKIYSEAFEGGFKLTVEDN-----------------AGNYQKPSQDHVGLGMEIVDKRL 526
Cdd:smart00387 10 LSNLLDNAIKY----TPEGGRITVTLERDGDHVEITVEDNgpgippedlekifepffRTDKRSRKIGGTGLGLSIVKKLV 85
|
90 100
....*....|....*....|....*...
gi 515674171 527 TNFFGQdsaLKIESQPQKFTRMSFIIPI 554
Cdd:smart00387 86 ELHGGE---ISVESEPGGGTTFTITLPL 110
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
442-553 |
4.71e-05 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 45.77 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 442 DRLEVEWDIDPQLY----ESQLPSfTLQPLVENAIKHgisnMLEGGKVKIYSEAFEGGFKLTVEDNAgnyQKPSQDHV-- 515
Cdd:PRK11006 297 GKHTITFEVDNSLKvfgnEDQLRS-AISNLVYNAVNH----TPEGTHITVRWQRVPQGAEFSVEDNG---PGIAPEHIpr 368
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 515674171 516 -------------------GLGMEIVDKRLTNffgQDSALKIESQPQKFTRMSFIIP 553
Cdd:PRK11006 369 lterfyrvdkarsrqtggsGLGLAIVKHALSH---HDSRLEIESEVGKGTRFSFVLP 422
|
|
| GAF_2 |
pfam13185 |
GAF domain; The GAF domain is named after some of the proteins it is found in, including ... |
242-348 |
1.01e-04 |
|
GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 433019 [Multi-domain] Cd Length: 137 Bit Score: 42.45 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 242 VGAVAITDREKILAFVGIGDEHHI--PNTPISSQSTLTSMEQNDIIYL-DGKENPYQCSLS-QDCKLGSALIIPLRAGNE 317
Cdd:pfam13185 23 VGFILLVDDDGRLAAWGGAADELSaaLDDPPGEGLVGEALRTGRPVIVnDLAADPAKKGLPaGHAGLRSFLSVPLVSGGR 102
|
90 100 110
....*....|....*....|....*....|.
gi 515674171 318 VVGTIKLYEPKLKLFSTINMSMGEGIAQLLS 348
Cdd:pfam13185 103 VVGVLALGSNRPGAFDEEDLELLELLAEQAA 133
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LytS |
COG3275 |
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms]; |
307-554 |
1.40e-67 |
|
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
Pssm-ID: 442506 [Multi-domain] Cd Length: 352 Bit Score: 222.44 E-value: 1.40e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 307 ALIIPLRAGNEVVGTIKLYEPKLKLFSTINMSMGEGIAQLLSSQILFSNYQQQQTLLTQAEIKLLHAQVNPHFLFNALNT 386
Cdd:COG3275 100 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPHFLFNTLNS 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 387 ISAVTRRDPDKARELIQHLSHFFRSNLKQN-INTVKLKDELAHVNAYLTIEKARFTDRLEVEWDIDPQLYESQLPSFTLQ 465
Cdd:COG3275 180 IYSLIREDPEKARELLLKLSDLLRYSLYESdKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDLLIPPLLLQ 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 466 PLVENAIKHGISNMLEGGKVKIYSEAFEGGFKLTVEDNAGNYQ-KPSQDHVGLGMEIVDKRLTNFFGQDSALKIESQPQK 544
Cdd:COG3275 260 PLVENAIKHGISSKEGGGTISISIEVEGDRLVIEVENNGVGIQpKKKKKGSGIGLKNVRERLELLYGDKYSLEIESTDGG 339
|
250
....*....|
gi 515674171 545 FTRMSFIIPI 554
Cdd:COG3275 340 GTKVTLKIPL 349
|
|
| 5TM-5TMR_LYT |
pfam07694 |
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors ... |
24-194 |
9.04e-64 |
|
5TMR of 5TMR-LYT; This entry represents the transmembrane region of the 5TM-LYT (5TM Receptors of the LytS-YhcK type).
Pssm-ID: 429599 Cd Length: 170 Bit Score: 206.27 E-value: 9.04e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 24 TPLILPLL-SISSRLSHKISCYVLFSLFCIMGTYFGLQIN-DAIANTRAMGAVMGGLFGGPVVGFAVGFTGGIHRYSLGG 101
Cdd:pfam07694 1 IPLFRRLLsKRRLRLKDKVLLGLIFGLFSILGTYTGIEIEpGAIANTRAVGIVLAGLLGGPIVGLIAGLIAGLHRYFLGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 102 FTDLACAISTTAEGLIGGLLHVYLVRKNKasqLFNPLVVFSVTLFAEIIQMIILLAVAKPFEQSYALVSDIAAPMIIANS 181
Cdd:pfam07694 81 FTALACGISTILAGLIAGLLHRRLKRRRR---LISPLLAFLIGLIAEILQMLLILLLALPFDLALALVKTIALPMILVNS 157
|
170
....*....|...
gi 515674171 182 VGAALFMSIIQDR 194
Cdd:pfam07694 158 LGTAIFLSILRDR 170
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
366-554 |
1.78e-54 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 190.61 E-value: 1.78e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 366 AEIKLLHAQVNPHFLFNALNTISA-VTRRDPDKARELIQHLSHFFRSNLKQNINTVKLKDELAHVNAYLTIEKARFTDRL 444
Cdd:COG2972 242 AELKALQAQINPHFLFNTLNSIRWlAELEDPEEAEEMLEALSKLLRYSLSKGDELVTLEEELELIKSYLEIQKLRFGDRL 321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 445 EVEWDIDPQLYESQLPSFTLQPLVENAIKHGISNMLEGGKVKIYSEAFEGGFKLTVEDNAG-----------NYQKPSQD 513
Cdd:COG2972 322 EVEIEIDEELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEGDRLVITVEDNGVgmpeeklekllEELSSKGE 401
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 515674171 514 HVGLGMEIVDKRLTNFFGQDSALKIESQPQKFTRMSFIIPI 554
Cdd:COG2972 402 GRGIGLRNVRERLKLYYGEEYGLEIESEPGEGTTVTIRIPL 442
|
|
| His_kinase |
pfam06580 |
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ... |
366-444 |
5.90e-32 |
|
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.
Pssm-ID: 461952 [Multi-domain] Cd Length: 79 Bit Score: 117.93 E-value: 5.90e-32
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 515674171 366 AEIKLLHAQVNPHFLFNALNTISAVTRRDPDKARELIQHLSHFFRSNLKQNINTVKLKDELAHVNAYLTIEKARFTDRL 444
Cdd:pfam06580 1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLYEGEELVTLEEELEFLENYLEIQKIRFGDRL 79
|
|
| HATPase_YehU-like |
cd16956 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
459-553 |
3.27e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YehU; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Escherichia coli YehU, a HK of the two-component system (TCS) YehU-YehT which is involved in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase); some have a GAF sensor domain while some have a cupin domain.
Pssm-ID: 340432 [Multi-domain] Cd Length: 101 Bit Score: 97.12 E-value: 3.27e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 459 LPSFTLQPLVENAIKHGISNMLEGGKVKIYSEAFEGGFKLTVEDNAGNYQ------KPSQDHVGLGMEIVDKRLTNFFGQ 532
Cdd:cd16956 1 LPFLTLQPIVENAVKHGLSGLLDGGRVEITARLDGQHLLLEVEDNGGGMDpdtlarILIRSSNGLGLNLVDKRLRQAFGN 80
|
90 100
....*....|....*....|.
gi 515674171 533 DSALKIESQPQKFTRMSFIIP 553
Cdd:cd16956 81 DYGLDIECAPGEGTRITIRLP 101
|
|
| HATPase_YpdA-YehU-LytS-like |
cd16924 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
459-553 |
1.65e-23 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340401 [Multi-domain] Cd Length: 103 Bit Score: 95.21 E-value: 1.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 459 LPSFTLQPLVENAIKHGISNMLEGGKVKIySEAFEGGF-KLTVEDNAGNYQ--------KPSQDHVGLGMEIVDKRLTNF 529
Cdd:cd16924 1 IPPFTLQPLVENAIQHGLSPLTDKGVVTI-SALKEDNHvMIEVEDNGRGIDpkvlnilgKKPKEGNGIGLYNVHQRLILL 79
|
90 100
....*....|....*....|....
gi 515674171 530 FGQDSALKIESQPQKFTRMSFIIP 553
Cdd:cd16924 80 FGEDYGIHIASEPDKGTRITFTIP 103
|
|
| HATPase_LytS-like |
cd16957 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
459-553 |
9.25e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.
Pssm-ID: 340433 [Multi-domain] Cd Length: 106 Bit Score: 64.75 E-value: 9.25e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 459 LPSFTLQPLVENAIKHGISNMLEGGKVKIYSEAFEGGFKLTVEDNA-----------GNYQKPSQDHVGLGMEIVDKRLT 527
Cdd:cd16957 1 VPPFALQVLVENAIRHAFPKRKENNEVRVVVKKDQHKVHVSVSDNGqgipeerldllGKTTVTSEKGTGTALENLNRRLI 80
|
90 100
....*....|....*....|....*.
gi 515674171 528 NFFGQDSALKIESQPQKFTRMSFIIP 553
Cdd:cd16957 81 GLFGSEACLHIESEVHGGTEVWFVIP 106
|
|
| HATPase_YpdA-like |
cd16955 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
459-553 |
1.30e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340431 [Multi-domain] Cd Length: 102 Bit Score: 64.02 E-value: 1.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 459 LPSFTLQPLVENAIKHGISNMLEGGKVKI-YSEAFEGGFKLTVEDNA--------GNYQKPSQDHVGLGMEIVDKRLTNF 529
Cdd:cd16955 1 IPKLMIQPLVENAIVHGIQEKKGKGVVKIsVKKQLKNRLHIAVEDNGigispkviERVEQDEMPGNKIGLLNVHQRLKLG 80
|
90 100
....*....|....*....|....
gi 515674171 530 FGqdSALKIESQPQKFTRMSFIIP 553
Cdd:cd16955 81 YG--EGLHIRSRPDPGTLIAFYIP 102
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
464-554 |
2.77e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 46.10 E-value: 2.77e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 464 LQPLVENAIKHgisnMLEGGKVKIYSEAFEGGFKLTVEDN-----------------AGNYQKPSQDHVGLGMEIVDKRL 526
Cdd:smart00387 10 LSNLLDNAIKY----TPEGGRITVTLERDGDHVEITVEDNgpgippedlekifepffRTDKRSRKIGGTGLGLSIVKKLV 85
|
90 100
....*....|....*....|....*...
gi 515674171 527 TNFFGQdsaLKIESQPQKFTRMSFIIPI 554
Cdd:smart00387 86 ELHGGE---ISVESEPGGGTTFTITLPL 110
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
442-553 |
4.71e-05 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 45.77 E-value: 4.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 442 DRLEVEWDIDPQLY----ESQLPSfTLQPLVENAIKHgisnMLEGGKVKIYSEAFEGGFKLTVEDNAgnyQKPSQDHV-- 515
Cdd:PRK11006 297 GKHTITFEVDNSLKvfgnEDQLRS-AISNLVYNAVNH----TPEGTHITVRWQRVPQGAEFSVEDNG---PGIAPEHIpr 368
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 515674171 516 -------------------GLGMEIVDKRLTNffgQDSALKIESQPQKFTRMSFIIP 553
Cdd:PRK11006 369 lterfyrvdkarsrqtggsGLGLAIVKHALSH---HDSRLEIESEVGKGTRFSFVLP 422
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
382-554 |
8.62e-05 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 44.84 E-value: 8.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 382 NALNTISA-VTRRDPDKARELIQHLShffrSNLKQNINTVKLKDELAHVNAyLTIEKARFTDRLEVEWDIDPqlyESQLP 460
Cdd:COG3290 202 NHLHTISGlLQLGEYDEALEYIDEIS----EELQELIDSLLSRIGNPVLAA-LLLGKAARARERGIDLTIDI---DSDLP 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 461 SFTLQP---------LVENAIKHGISNMLEGGKVKIYSEAFEGGFKLTVEDN--------------AGNYQKPSQDHvGL 517
Cdd:COG3290 274 DLPLSDtdlvtilgnLLDNAIEAVEKLPEEERRVELSIRDDGDELVIEVEDSgpgipeellekifeRGFSTKLGEGR-GL 352
|
170 180 190
....*....|....*....|....*....|....*..
gi 515674171 518 GMEIVDKRLTNFFGQdsaLKIESQPQKFTRMSFIIPI 554
Cdd:COG3290 353 GLALVKQIVEKYGGT---IEVESEEGEGTVFTVRLPK 386
|
|
| GAF_2 |
pfam13185 |
GAF domain; The GAF domain is named after some of the proteins it is found in, including ... |
242-348 |
1.01e-04 |
|
GAF domain; The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain. This domain can bind O2, CO and NO (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 433019 [Multi-domain] Cd Length: 137 Bit Score: 42.45 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 242 VGAVAITDREKILAFVGIGDEHHI--PNTPISSQSTLTSMEQNDIIYL-DGKENPYQCSLS-QDCKLGSALIIPLRAGNE 317
Cdd:pfam13185 23 VGFILLVDDDGRLAAWGGAADELSaaLDDPPGEGLVGEALRTGRPVIVnDLAADPAKKGLPaGHAGLRSFLSVPLVSGGR 102
|
90 100 110
....*....|....*....|....*....|.
gi 515674171 318 VVGTIKLYEPKLKLFSTINMSMGEGIAQLLS 348
Cdd:pfam13185 103 VVGVLALGSNRPGAFDEEDLELLELLAEQAA 133
|
|
| GAF_3 |
pfam13492 |
GAF domain; |
240-351 |
2.23e-04 |
|
GAF domain;
Pssm-ID: 433253 [Multi-domain] Cd Length: 129 Bit Score: 41.20 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 240 TNVGAVAITDREKILAFVGIG-DEHHIPNTPISSQSTLTS---MEQNDIIYLDGKENPyqcslsqDCKLGSALIIPLRAG 315
Cdd:pfam13492 19 AERAAVYLLDEDGNKLQVAAGyDGEPDPSESLDADSPLARralSSGEPISGLGSAGED-------GLPDGPALVVPLVAG 91
|
90 100 110
....*....|....*....|....*....|....*.
gi 515674171 316 NEVVGTIKLYEPKLKLFSTINMSMGEGIAQLLSSQI 351
Cdd:pfam13492 92 RRVIGVLALASSKPRAFDAEDLRLLESLAAQIATAI 127
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
384-554 |
3.25e-04 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 42.68 E-value: 3.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 384 LNTISAVTRRDPDKARELIQHLshffRSNLKQNINTVKlkdELAHVNAYLTIEKARFTDRLE-------------VEWDI 450
Cdd:COG4585 76 LEAARRLLDADPEAAREELEEI----RELAREALAELR---RLVRGLRPPALDDLGLAAALEelaerllraagirVELDV 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 451 DPQLYEsqLPS-------FTLQPLVENAIKHGisnmlEGGKVKIYSEAFEGGFKLTVEDN--AGNYQKPSQDHVGL-GME 520
Cdd:COG4585 149 DGDPDR--LPPevelalyRIVQEALTNALKHA-----GATRVTVTLEVDDGELTLTVRDDgvGFDPEAAPGGGLGLrGMR 221
|
170 180 190
....*....|....*....|....*....|....
gi 515674171 521 ivdKRLTNFFGQdsaLKIESQPQKFTRMSFIIPI 554
Cdd:COG4585 222 ---ERAEALGGT---LTIGSAPGGGTRVRATLPL 249
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
383-554 |
1.02e-03 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 41.43 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 383 ALNTISAVTRRdpdkARELIQHLSHFFR---SNLKQNINTVKLKDELAHVNAYLTIEKARftDRLEVEWDIDPQLYESQL 459
Cdd:COG0642 146 YLETILRSADR----LLRLINDLLDLSRleaGKLELEPEPVDLAELLEEVVELFRPLAEE--KGIELELDLPDDLPTVRG 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 460 PSFTLQP----LVENAIKHgisnMLEGGKVKIYSEAFEGGFKLTVEDNAGNYQKPSQDHV----------------GLGM 519
Cdd:COG0642 220 DPDRLRQvllnLLSNAIKY----TPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIfepffrtdpsrrgggtGLGL 295
|
170 180 190
....*....|....*....|....*....|....*
gi 515674171 520 EIVdKRLTNFFGqdSALKIESQPQKFTRMSFIIPI 554
Cdd:COG0642 296 AIV-KRIVELHG--GTIEVESEPGKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
467-554 |
4.78e-03 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 38.73 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 467 LVENAIKHGisnmLEGGKVKIYSEAFEGGFKLTVEDN-------------AGNYQ---KPSQDHVGLGMEIVdKRLTNFF 530
Cdd:COG2205 140 LLDNAIKYS----PPGGTITISARREGDGVRISVSDNgpgipeeelerifERFYRgdnSRGEGGTGLGLAIV-KRIVEAH 214
|
90 100
....*....|....*....|....
gi 515674171 531 GqdSALKIESQPQKFTRMSFIIPI 554
Cdd:COG2205 215 G--GTIWVESEPGGGTTFTVTLPL 236
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
464-553 |
6.66e-03 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 36.58 E-value: 6.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515674171 464 LQPLVENAIKHgisnMLEGGKVKIySEAFEGGFKLTVEDNA---------------GNYQKPSQDHVGLGMEIVdKRLTN 528
Cdd:pfam02518 10 LSNLLDNALKH----AAKAGEITV-TLSEGGELTLTVEDNGigippedlprifepfSTADKRGGGGTGLGLSIV-RKLVE 83
|
90 100
....*....|....*....|....*
gi 515674171 529 FFGQDsaLKIESQPQKFTRMSFIIP 553
Cdd:pfam02518 84 LLGGT--ITVESEPGGGTTVTLTLP 106
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