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Conserved domains on  [gi|515742605|ref|WP_017175205|]
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MULTISPECIES: trehalose operon repressor [Staphylococcus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
trehalos_R_Bsub super family cl37105
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 5-238 8.49e-75

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


The actual alignment was detected with superfamily member TIGR02404:

Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 226.48  E-value: 8.49e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605    5 KFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDITEFPFSDLISF 84
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   85 KEVKEKLNLNHETYVLVNEIIKASDVPLVKeQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIARKSIY 164
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKEDPLPETLAQ-LTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIY 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515742605  165 DYLEKELHLDISYSNKSITFEPFKDFEYQVFGKVHHPYTATVRSTVFLKDTTRFQYNVSKHLATEFKFNEFSRR 238
Cdd:TIGR02404 160 QYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
 
Name Accession Description Interval E-value
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 5-238 8.49e-75

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 226.48  E-value: 8.49e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605    5 KFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDITEFPFSDLISF 84
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   85 KEVKEKLNLNHETYVLVNEIIKASDVPLVKeQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIARKSIY 164
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKEDPLPETLAQ-LTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIY 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515742605  165 DYLEKELHLDISYSNKSITFEPFKDFEYQVFGKVHHPYTATVRSTVFLKDTTRFQYNVSKHLATEFKFNEFSRR 238
Cdd:TIGR02404 160 QYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-238 1.56e-50

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 164.65  E-value: 1.56e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   5 KFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDITEfPFSDLISF 84
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY-PLSRLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605  85 KEVKEKLNLNHETYVLVNEIIKASdvPLVKEQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNE-IARKSI 163
Cdd:COG2188   85 TEELRARGREPSTRVLSAERVPAD--EEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEdLETGSL 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515742605 164 YDYLEKELHLDISYSNKSITFEPFKDFEYQVFG-KVHHPyTATVRSTVFLKDTTRFQYNVSKHLATEFKF-NEFSRR 238
Cdd:COG2188  163 YELLEERYGLRITRAEQRIEAVLADAEEAELLGvPPGAP-VLVIERVTYDADGRPVEYSRSYYRGDRYRFvVELRRR 238
PRK09764 PRK09764
GntR family transcriptional regulator;
5-239 3.25e-22

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 91.43  E-value: 3.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   5 KFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDItEFPFSDLISF 84
Cdd:PRK09764   6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERV-NYDIFQLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605  85 KEVKEKLNLNHETYVLVNEIIKASDvpLVKEQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIARKSIY 164
Cdd:PRK09764  85 DEKLSDRHVDTHSEVLIFEVIPADD--FLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKY 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515742605 165 DYLEKELHLDISYSNKSIT-FEPFKDFEYQVFGKVHHPyTATVRSTVFLKDTTRFQYNVSKHLATEFKFNEFSRRQ 239
Cdd:PRK09764 163 HFIEEVKKMVIDRSEQEIIpLMPTEEMSRLLNISQTKP-ILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRK 237
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 5-68 3.60e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 80.95  E-value: 3.60e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515742605   5 KFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIV 68
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 91-231 1.05e-17

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 76.87  E-value: 1.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   91 LNLNHETYVLVNEIIKASDvpLVKEQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIARK-SIYDYLEK 169
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASA--EIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515742605  170 ELHLDISYSNKSITFEPFKDFEYQVFG-KVHHPyTATVRSTVFLKDTTRFQYNVSKHLATEFK 231
Cdd:pfam07702  80 RYGLPITRAEQTIEAVLADAEEAELLGiSPGAP-VLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 91-231 1.30e-17

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 76.56  E-value: 1.30e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605    91 LNLNHETYVLVNEIIKASdvPLVKEQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIARKSIYDYLEKE 170
Cdd:smart00866   2 QGRKPTTKVLSFERVPAD--EELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEER 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515742605   171 LHLDISYS---NKSITFEPFKDFEYQVFG-KVHHPyTATVRSTVFLKDTTRFQYNVSKHLATEFK 231
Cdd:smart00866  80 LGLKIVRStraEQTITAVLADEEEAELLGlPPGAP-LLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
 
Name Accession Description Interval E-value
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 5-238 8.49e-75

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 226.48  E-value: 8.49e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605    5 KFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDITEFPFSDLISF 84
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVLNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   85 KEVKEKLNLNHETYVLVNEIIKASDVPLVKeQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIARKSIY 164
Cdd:TIGR02404  81 KELNETLGLDSKTEVVELDKEDPLPETLAQ-LTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDSIY 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515742605  165 DYLEKELHLDISYSNKSITFEPFKDFEYQVFGKVHHPYTATVRSTVFLKDTTRFQYNVSKHLATEFKFNEFSRR 238
Cdd:TIGR02404 160 QYLENELGLAISYAQKEITVEPCTDEDKKLLDLDGDDHVVVVKSKTFLEDTRQFQYTESRHRLDKFKFVDFARR 233
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-238 1.56e-50

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 164.65  E-value: 1.56e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   5 KFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDITEfPFSDLISF 84
Cdd:COG2188    6 LYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEY-PLSRLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605  85 KEVKEKLNLNHETYVLVNEIIKASdvPLVKEQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNE-IARKSI 163
Cdd:COG2188   85 TEELRARGREPSTRVLSAERVPAD--EEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEdLETGSL 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 515742605 164 YDYLEKELHLDISYSNKSITFEPFKDFEYQVFG-KVHHPyTATVRSTVFLKDTTRFQYNVSKHLATEFKF-NEFSRR 238
Cdd:COG2188  163 YELLEERYGLRITRAEQRIEAVLADAEEAELLGvPPGAP-VLVIERVTYDADGRPVEYSRSYYRGDRYRFvVELRRR 238
PRK09764 PRK09764
GntR family transcriptional regulator;
5-239 3.25e-22

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 91.43  E-value: 3.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   5 KFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDItEFPFSDLISF 84
Cdd:PRK09764   6 LYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERV-NYDIFQLTSF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605  85 KEVKEKLNLNHETYVLVNEIIKASDvpLVKEQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIARKSIY 164
Cdd:PRK09764  85 DEKLSDRHVDTHSEVLIFEVIPADD--FLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMENSKY 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515742605 165 DYLEKELHLDISYSNKSIT-FEPFKDFEYQVFGKVHHPyTATVRSTVFLKDTTRFQYNVSKHLATEFKFNEFSRRQ 239
Cdd:PRK09764 163 HFIEEVKKMVIDRSEQEIIpLMPTEEMSRLLNISQTKP-ILEKVSRGYLVDGRVFEYSRNAFNTDDYKFTLIAQRK 237
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 5-68 3.60e-20

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 80.95  E-value: 3.60e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 515742605   5 KFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIV 68
Cdd:cd07377    2 LYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFV 65
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 91-231 1.05e-17

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 76.87  E-value: 1.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   91 LNLNHETYVLVNEIIKASDvpLVKEQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIARK-SIYDYLEK 169
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASA--EIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEgSLYDYLEE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 515742605  170 ELHLDISYSNKSITFEPFKDFEYQVFG-KVHHPyTATVRSTVFLKDTTRFQYNVSKHLATEFK 231
Cdd:pfam07702  80 RYGLPITRAEQTIEAVLADAEEAELLGiSPGAP-VLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 91-231 1.30e-17

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 76.56  E-value: 1.30e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605    91 LNLNHETYVLVNEIIKASdvPLVKEQLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIARKSIYDYLEKE 170
Cdd:smart00866   2 QGRKPTTKVLSFERVPAD--EELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEER 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 515742605   171 LHLDISYS---NKSITFEPFKDFEYQVFG-KVHHPyTATVRSTVFLKDTTRFQYNVSKHLATEFK 231
Cdd:smart00866  80 LGLKIVRStraEQTITAVLADEEEAELLGlPPGAP-LLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 9-68 6.91e-17

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 72.26  E-value: 6.91e-17
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605    9 IYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIV 68
Cdd:pfam00392   5 VYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
9-68 3.70e-15

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 67.60  E-value: 3.70e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605     9 IYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIV 68
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 9-169 9.69e-13

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 65.58  E-value: 9.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605    9 IYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDITeFPFSDLISFKEvk 88
Cdd:TIGR02325  13 IADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRID-YPLSARTRFSQ-- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   89 eklNLNHETYVLVNEIIKASDVPLVKE---QLGLRNNDLLCHVVRSRSVNGKVKILDEDYFLTSLVPKISNEIAR-KSIY 164
Cdd:TIGR02325  90 ---NLADQGREPTGELLLSDLEPASAEladALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYAAsGSIT 166


                  ....*
gi 515742605  165 DYLEK 169
Cdd:TIGR02325 167 DALRE 171
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
9-84 9.35e-12

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 62.64  E-value: 9.35e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 515742605   9 IYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIViqQDITEFPFSDLISF 84
Cdd:COG2186   12 VAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFV--REPSPWALLDPLAL 85
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
9-68 1.88e-11

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 59.42  E-value: 1.88e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   9 IYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIV 68
Cdd:COG1725   15 IADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFV 74
PRK11402 PRK11402
transcriptional regulator PhoB;
6-115 8.92e-11

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 59.85  E-value: 8.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   6 FAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDI----------TE 75
Cdd:PRK11402  11 YATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVenalltvsgfTD 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 515742605  76 F-------PFSDLISF-----KEVKEKLNLNHETYVL-VNEIIKASDVPLVKE 115
Cdd:PRK11402  91 FgvsqgkaTKEKVIEQervsaAPFCEKLNIPGNSEVFhLCRVMYLDKEPLFID 143
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 9-68 8.97e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 57.92  E-value: 8.97e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   9 IYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIV 68
Cdd:COG1167   17 LADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFV 76
PRK14999 PRK14999
histidine utilization repressor; Provisional
 7-149 8.06e-09

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 54.55  E-value: 8.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   7 AVIYEKLKKDISE----GIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDITefpfSDLI 82
Cdd:PRK14999  11 APFYETVKQDICKkiagGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQ----SALF 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605  83 SFKEVKEKL---NLNHETYVLVNEIIKASdvPLVKEQLGLRNNDLLCHVV------------RSRSVNGKV--KILDEDY 145
Cdd:PRK14999  87 EVRSIAEEIaarRHQHRCEVLTLERVRAN--AIQASALNVNESDVIFHSImvhyendlpvqiEDRCVNADIavDYLTQDY 164


                 ....
gi 515742605 146 FLTS 149
Cdd:PRK14999 165 RQTT 168
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
9-68 1.05e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 53.77  E-value: 1.05e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   9 IYEKLKKDISEGIYLYGEQLpSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIV 68
Cdd:COG1802   16 VYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARV 74
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 22-183 4.15e-08

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 52.47  E-value: 4.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605  22 YLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQDItEFPFSDLISFKEvkeklNLNHETYVLV 101
Cdd:PRK10079  29 YRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPY-DYPLNAQARFSQ-----NLLDQGSHPT 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605 102 NEIIKASDVPL---VKEQLGLRNNDLLCHVVRSRSVNGkVKILDEDYFLTSLV--PKISNeIARKSIYDYLEKELHLDIS 176
Cdd:PRK10079 103 SEKLLSVLRPAsghVADALGITEGENVIHLRTLRRVNG-VALCLIDHYFADLTwwPTLQR-FDSGSLHDFLREQLGIALR 180


                 ....*..
gi 515742605 177 YSNKSIT 183
Cdd:PRK10079 181 RSQTRIS 187
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 9-59 5.52e-08

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 51.95  E-value: 5.52e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 515742605   9 IYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQ 59
Cdd:PRK03837  18 VEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQ 68
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 8-68 3.86e-07

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 49.38  E-value: 3.86e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 515742605   8 VIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIV 68
Cdd:PRK09990  11 VVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFV 71
PRK11523 PRK11523
transcriptional regulator ExuR;
13-69 3.01e-06

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 46.76  E-value: 3.01e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 515742605  13 LKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVI 69
Cdd:PRK11523  17 LKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHVV 73
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
3-83 6.54e-06

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 45.78  E-value: 6.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 515742605   3 QQKFA-VIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIV---IQQDITEfPF 78
Cdd:PRK09464   8 QPKLSdVIEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVqssLWQSFSD-PL 86


                 ....*
gi 515742605  79 SDLIS 83
Cdd:PRK09464  87 VELLS 91
PRK10225 PRK10225
Uxu operon transcriptional regulator;
3-70 4.09e-05

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 43.47  E-value: 4.09e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 515742605   3 QQKFAVIYEKLKKDISEGIYLYGEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQ 70
Cdd:PRK10225   8 QRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLD 75
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 25-71 1.18e-03

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 38.98  E-value: 1.18e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 515742605  25 GEQLPSERELVETYHSSRETVRKALELLANDGMIQKIKGKGSIVIQQ 71
Cdd:PRK10421  23 GMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWR 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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